The role of endothelium in regulating stem cell homing to the liver
Lead Research Organisation:
University of Birmingham
Department Name: Clinical and Experimental Medicine
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Weston CJ
(2011)
Hepatic consequences of vascular adhesion protein-1 expression.
in Journal of neural transmission (Vienna, Austria : 1996)
Lalor PF
(2013)
Hepatic sinusoidal endothelium avidly binds platelets in an integrin-dependent manner, leading to platelet and endothelial activation and leukocyte recruitment.
in American journal of physiology. Gastrointestinal and liver physiology
Davies SP
(2019)
Hepatocytes Delete Regulatory T Cells by Enclysis, a CD4 T Cell Engulfment Process.
in Cell reports
Lalor PF
(2006)
Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo.
in World journal of gastroenterology
Patten DA
(2017)
Human liver sinusoidal endothelial cells promote intracellular crawling of lymphocytes during recruitment: A new step in migration.
in Hepatology (Baltimore, Md.)
Resheq YJ
(2017)
Impaired Transmigration of Myeloid-Derived Suppressor Cells across Human Sinusoidal Endothelium Is Associated with Decreased Expression of CD13.
in Journal of immunology (Baltimore, Md. : 1950)
Chen YY
(2019)
Intrahepatic macrophage populations in the pathophysiology of primary sclerosing cholangitis.
in JHEP reports : innovation in hepatology
Oo YH
(2019)
Liver homing of clinical grade Tregs after therapeutic infusion in patients with autoimmune hepatitis.
in JHEP reports : innovation in hepatology
Jeffery HC
(2017)
Low-dose interleukin-2 promotes STAT-5 phosphorylation, T survival and CTLA-4-dependent function in autoimmune liver diseases.
in Clinical and experimental immunology
Shetty S
(2008)
Lymphocyte recruitment to the liver: molecular insights into the pathogenesis of liver injury and hepatitis.
in Toxicology
Adams DH
(2010)
Mechanisms of immune-mediated liver injury.
in Toxicological sciences : an official journal of the Society of Toxicology
Triantafyllou E
(2018)
MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure.
in Gut
Liaskou E
(2013)
Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics.
in Hepatology (Baltimore, Md.)
Trivedi PJ
(2013)
Mucosal immunity in liver autoimmunity: a comprehensive review.
in Journal of autoimmunity
De Graaf KL
(2018)
NI-0801, an anti-chemokine (C-X-C motif) ligand 10 antibody, in patients with primary biliary cholangitis and an incomplete response to ursodeoxycholic acid.
in Hepatology communications
Lutz P
(2019)
NK Cells in Ascites From Liver Disease Patients Display a Particular Phenotype and Take Part in Antibacterial Immune Response.
in Frontiers in immunology
Rowe IA
(2014)
Paracrine signals from liver sinusoidal endothelium regulate hepatitis C virus replication.
in Hepatology (Baltimore, Md.)
Malehmir M
(2019)
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer.
in Nature medicine
Chauhan A
(2017)
Platelets Are Critical Drivers of Illness Behaviors During Liver Inflammation.
in Gastroenterology
Hirschfield GM
(2013)
Primary sclerosing cholangitis.
in Lancet (London, England)
Liaskou E
(2011)
Regulation of mucosal addressin cell adhesion molecule 1 expression in human and mice by vascular adhesion protein 1 amine oxidase activity.
in Hepatology (Baltimore, Md.)
Oo YH
(2012)
Regulatory T cells and autoimmune hepatitis: defective cells or a hostile environment?
in Journal of hepatology
| Description | NIHR BRU in Cell and Immunotherapy for LIver disease |
| Amount | £6,500,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR Birmingham Liver Biomedical Research Unit |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2008 |
| End | 09/2012 |
| Description | Edinburgh |
| Organisation | University of Edinburgh |
| Department | MRC Centre for Inflammation Research |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have developed a successful local collaboration with my colleague Dr Newsome andPorfs Forbes and Iredale in Edinburgh resulting an ongoing collaboration which ahs contributed to a recent MRC grant awarded in 2009. |
| Collaborator Contribution | We have several ongoing collaborations sharing technology and expertise |
| Impact | Ongoing publications and research collaborations |
| Start Year | 2008 |
| Description | Guardian |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | -Article in the Guardian on liver disease and transplantation www.guardian.co.uk/society/2008/nov/28/organ-donation-health-policy-transplant Incraesed public profile |
| Year(s) Of Engagement Activity | 2008 |
| Description | PPI initiatve |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | 20 members of the public and patients attended a seminar/workshop on liver research in Birmingham Panel agreed to review our research patient information sheets |
| Year(s) Of Engagement Activity | 2010,2011,2012,2013,2014 |
| Description | PSC |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Hosted meeting of the PSC patient group to discuss our research Took on role as Trustee of the Charity in 2013 Asked to host the meeting on an annual basis Helped develop a research funding programme for the charity Helped write guieldlines and provide clinical advice |
| Year(s) Of Engagement Activity | 2009,2010,2011,2012,2013,2014 |
| URL | http://www.pscsupport.org.uk/?gclid=Cj0KEQiAp4yjBRCE_enjmpug944BEiQATCpLvU1wXwOybMo7BSFeWs_AEICLJAiy... |
| Description | Public engagement |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | PSC Trust meeting London Discussion of the potential for stem cell therapy in liver disease. A funding initiative to support genomics in liver disease. |
| Year(s) Of Engagement Activity | 2007 |
| Description | Schools |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | -Students from local schools come to the department to learn about research and to carry out short projects Goldcrest award and Nuffield Bursary award |
| Year(s) Of Engagement Activity | 2007,2008,2009,2010,2011,2012,2013,2014,2015 |
| Description | World hepatitis day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | -Hosted public meeting for World hepatitis day attended by patient groups, politicians, press. Featured on Kerrang Radio & Naked scientist website http://www.thenakedscientists.com/HTML/podcasts/specials/show/2009.06.10/ Increased profile |
| Year(s) Of Engagement Activity | 2009 |