Clinical Research in the UK - National Prion Cohort
Lead Research Organisation:
University College London
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Canas LS
(2019)
Prion disease diagnosis using subject-specific imaging biomarkers within a multi-kernel Gaussian process.
in NeuroImage. Clinical
Clayton EL
(2018)
Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown.
in Brain : a journal of neurology
Corbett GT
(2020)
PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins.
in Acta neuropathologica
Dabin LC
(2020)
Altered DNA methylation profiles in blood from patients with sporadic Creutzfeldt-Jakob disease.
in Acta neuropathologica
Eisenmenger L
(2016)
Evolution of Diffusion-Weighted Magnetic Resonance Imaging Signal Abnormality in Sporadic Creutzfeldt-Jakob Disease, With Histopathological Correlation.
in JAMA neurology
Ford L
(2019)
The most problematic symptoms of prion disease - an analysis of carer experiences.
in International psychogeriatrics
Hassan A
(2021)
Case report of homozygous E200D mutation of PRNP in apparently sporadic Creutzfeldt-Jakob disease.
in BMC neurology
Hyare H
(2020)
Putaminal diffusion tensor imaging measures predict disease severity across human prion diseases.
in Brain communications
Jones E
(2020)
Identification of novel risk loci and causal insights for sporadic Creutzfeldt-Jakob disease: a genome-wide association study
in The Lancet Neurology
| Description | 19/20 MRC capital Equipment |
| Amount | £182,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 03/2020 |
| Description | MRC Block Grant Funding for 21/22 (Capital Equipment) |
| Amount | £100,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 03/2022 |
| Description | MRC World Class Labs Capital Funding 21/22 |
| Amount | £235,586 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 03/2022 |
| Description | NIHR UCLH Biomedical Research Centre |
| Amount | £1,000,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | UCLH/UCL Biomedical Research Centre |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 03/2022 |
| Description | Preclinical therapeutics development work |
| Amount | £49,741 (GBP) |
| Organisation | UCL Hospitals Charity |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 03/2021 |
| Description | The development of a monoclonal antibody treatment for CJD |
| Amount | £339,395 (GBP) |
| Organisation | UCL Hospitals Charity |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2017 |
| End | 08/2020 |
| Description | Australian CJD Support Group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Presented talk to the Australian CJD Support Group and participated in round table discussions |
| Year(s) Of Engagement Activity | 2017 |
| Description | CJD Support Network Committee Member |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Professor Simon Mead is an active Committee member and is involved in the organisation of events and formulation of policy. |
| Year(s) Of Engagement Activity | 2018,2019 |
| URL | http://www.cjdsupport.net/ |
| Description | Keynote Lecture at Eibsee Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote lecture: "Is Alzheimer's infectious?", given at the Eibsee meeting 2019 in Garmisch, Germany. The Eibsee Meeting 2019 brought together scientists and experts from all over the world to discuss special topics such as lysosomal dysfunction, glial contributions to neurodegeneration, identification of biomarkers and neuro-imaging. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://eibsee.web.med.uni-muenchen.de/program2019/index.html |
| Description | Keynote opening lecture at Amyloid Transmissibility Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited to take part in Amyloid Transmissibility Workshop and give keynote opening lecture on "Human transmission of amyloid-? pathology and its implications". The Amyloid Transmissibility Workshop brought together international partners (UK Dementia Research Institute, Red Cross, European Blood Agency, Institut du Cerveau et de la Moelle Epiniere, Mission Lucidity) and gathered researchers, neurosurgeons, blood transfusion experts and public health specialists to discuss the latest findings on the potential infectivity of amyloid pathology. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Lecture at Bristol Medico-Chirurgical Society on "Transmissible dementia - from kuru to CJD and BSE and the wider relevance of prions" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Lecture on "Transmissible dementia - from kuru to CJD and BSE and the wider relevance of prions" given at the Bristol Medico-Chirurgical Society which has a wide membership of health care professionals in Bristol. The society aims to promote the exchange of views between health professionals on local health matters and to contribute to informed debate within the professions. |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.bristolmedchi.co.uk/ |
| Description | Lecture at DZNE: "Transmissible dementia: past, present and future" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The DZNE lecture series presents world-leading scientists from life science research, covering the diverse research areas at the DZNE including fundamental biology, translational, clinical, epidemiological and systems medicine research. The lectures aim to foster an exchange between disciplines and catalyze scientific interactions. Furthermore, the lecture series puts an emphasis on enabling students and postdocs to informally interact with the speaker, including via a dedicated Speaker's Lunch following each Lecture. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.dzne.de/en/news/events/lecture-series/ |
| Description | Lecture at the University of Cambridge on "Prion propagation and its wider relevance in neurodegeneration" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Lecture on "Prion propagation and its wider relevance in neurodegeneration" given at the Centre for Misfolding Diseases (CMD) in the Chemistry Department at the University of Cambridge. Invited to present research on prions and neurodegenerative diseases to members of the Department. |
| Year(s) Of Engagement Activity | 2019 |
| Description | MRC Festival of Medical Research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Patient open day - presented talk and workshops |
| Year(s) Of Engagement Activity | 2017 |
| Description | MRC Prion Unit at UCL Open Day for At-risk Individuals |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | An update on the work of the Unit and its understanding of prion diseases was presented to an audience of at-risk individuals and/or their families. The presentations were followed by group discussions and a laboratory tour. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Member of the PRION 2019 International Scientific Advisory Committee |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited to be a member of the PRION 2019 International Scientific Advisory Committee to contribute to the planning and development of the scientific programme of Prion 2019 in Edmonton, Canada, an annual event for researchers involved in Prion diseases worldwide. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Open Day of the MRC Prion Unit at UCL |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Open day to discuss the work of the Unit and the National Prion Clinic, its role in understanding and treating prion diseases and its contribution to the mission of the Medical Research Council. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Presentation at Prion 2019, Edmonton |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on "A perspective on prion strains and their significance" given at Prion 2019, Edmonton, Canada, an annual event for researchers involved in Prion diseases worldwide. Researchers gather together to inform and interact with others working in the prion field. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Presentation at the Keystone Symposia meeting on Neurodegenerative Diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on "Prion neurodegeneration: towards an effective treatment and its relevance for Alzheimer's disease" given at the Keystone Symposia meeting on Neurodegenerative Diseases: New Insights and Therapeutic Opportunities.The conference aimed to address the current state of knowledge in this emerging area and to provide advanced discussion of these topics between scientists from different fields of research and foster new collaborations that may lead to new therapeutic opportunities for those suffering from neurodegenerative diseases. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://tks.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1653 |
| Description | Presentation to US Patient Group in Washington |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Presented talk to the CJD Foundation the US patient group. |
| Year(s) Of Engagement Activity | 2017 |
| Description | School visit |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | workshop on healthy eating as part of the Royal Society of Biology's Biology Week |
| Year(s) Of Engagement Activity | 2016 |
| Description | Seminar at Biogen on "Prion disease pathogenesis and therapeutics: wider relevance in Alzheimer's and other neurodegenerative conditions" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Seminar given on "Prion disease pathogenesis and therapeutics: wider relevance in Alzheimer's and other neurodegenerative conditions" at Biogen, Boston. Biogen is a global biotechnology company that develops innovative therapies for people living with serious neurological and neurodegenerative diseases. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Seminar at the John Innes Centre on "BSE, prion propagation and its wider relevance" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Seminar on "BSE, prion propagation and its wider relevance" given at the John Innes Centre to an audience that included a wide range of plant and microbial scientists from postgraduates to project leaders, chemists to molecular biologists and geneticists.The John Innes Centre is an independent, international centre of excellence in plant science, research, genetics and microbiology based in Norwich, UK. |
| Year(s) Of Engagement Activity | 2019 |
| Description | school visit |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Gave a short talk about what scientists do then helped children demonstrate their science activity to year 6 children - St Mary's ans St John's CE School, Barnet |
| Year(s) Of Engagement Activity | 2016 |