Clinical Research in the UK - National Prion Cohort

Lead Research Organisation: University College London
Department Name: UNLISTED

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

10 25 50

 
Description 19/20 MRC capital Equipment
Amount £182,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2019 
End 03/2020
 
Description MRC Block Grant Funding for 21/22 (Capital Equipment)
Amount £100,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2021 
End 03/2022
 
Description MRC World Class Labs Capital Funding 21/22
Amount £235,586 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2021 
End 03/2022
 
Description NIHR UCLH Biomedical Research Centre
Amount £1,000,000 (GBP)
Organisation National Institute for Health Research 
Department UCLH/UCL Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 03/2017 
End 03/2022
 
Description Preclinical therapeutics development work
Amount £49,741 (GBP)
Organisation UCL Hospitals Charity 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2019 
End 03/2021
 
Description The development of a monoclonal antibody treatment for CJD
Amount £339,395 (GBP)
Organisation UCL Hospitals Charity 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2017 
End 08/2020
 
Description Australian CJD Support Group 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Patients, carers and/or patient groups
Results and Impact Presented talk to the Australian CJD Support Group and participated in round table discussions
Year(s) Of Engagement Activity 2017
 
Description CJD Support Network Committee Member 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact Professor Simon Mead is an active Committee member and is involved in the organisation of events and formulation of policy.
Year(s) Of Engagement Activity 2018,2019
URL http://www.cjdsupport.net/
 
Description Keynote Lecture at Eibsee Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote lecture: "Is Alzheimer's infectious?", given at the Eibsee meeting 2019 in Garmisch, Germany. The Eibsee Meeting 2019 brought together scientists and experts from all over the world to discuss special topics such as lysosomal dysfunction, glial contributions to neurodegeneration, identification of biomarkers and neuro-imaging.
Year(s) Of Engagement Activity 2019
URL https://eibsee.web.med.uni-muenchen.de/program2019/index.html
 
Description Keynote opening lecture at Amyloid Transmissibility Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited to take part in Amyloid Transmissibility Workshop and give keynote opening lecture on "Human transmission of amyloid-? pathology and its implications". The Amyloid Transmissibility Workshop brought together international partners (UK Dementia Research Institute, Red Cross, European Blood Agency, Institut du Cerveau et de la Moelle Epiniere, Mission Lucidity) and gathered researchers, neurosurgeons, blood transfusion experts and public health specialists to discuss the latest findings on the potential infectivity of amyloid pathology.
Year(s) Of Engagement Activity 2019
 
Description Lecture at Bristol Medico-Chirurgical Society on "Transmissible dementia - from kuru to CJD and BSE and the wider relevance of prions" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Lecture on "Transmissible dementia - from kuru to CJD and BSE and the wider relevance of prions" given at the Bristol Medico-Chirurgical Society which has a wide membership of health care professionals in Bristol. The society aims to promote the exchange of views between health professionals on local health matters and to contribute to informed debate within the professions.
Year(s) Of Engagement Activity 2019
URL http://www.bristolmedchi.co.uk/
 
Description Lecture at DZNE: "Transmissible dementia: past, present and future" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The DZNE lecture series presents world-leading scientists from life science research, covering the diverse research areas at the DZNE including fundamental biology, translational, clinical, epidemiological and systems medicine research. The lectures aim to foster an exchange between disciplines and catalyze scientific interactions. Furthermore, the lecture series puts an emphasis on enabling students and postdocs to informally interact with the speaker, including via a dedicated Speaker's Lunch following each Lecture.
Year(s) Of Engagement Activity 2020
URL https://www.dzne.de/en/news/events/lecture-series/
 
Description Lecture at the University of Cambridge on "Prion propagation and its wider relevance in neurodegeneration" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Lecture on "Prion propagation and its wider relevance in neurodegeneration" given at the Centre for Misfolding Diseases (CMD) in the Chemistry Department at the University of Cambridge. Invited to present research on prions and neurodegenerative diseases to members of the Department.
Year(s) Of Engagement Activity 2019
 
Description MRC Festival of Medical Research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Patient open day - presented talk and workshops
Year(s) Of Engagement Activity 2017
 
Description MRC Prion Unit at UCL Open Day for At-risk Individuals 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact An update on the work of the Unit and its understanding of prion diseases was presented to an audience of at-risk individuals and/or their families. The presentations were followed by group discussions and a laboratory tour.
Year(s) Of Engagement Activity 2020
 
Description Member of the PRION 2019 International Scientific Advisory Committee 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited to be a member of the PRION 2019 International Scientific Advisory Committee to contribute to the planning and development of the scientific programme of Prion 2019 in Edmonton, Canada, an annual event for researchers involved in Prion diseases worldwide.
Year(s) Of Engagement Activity 2019
 
Description Open Day of the MRC Prion Unit at UCL 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact Open day to discuss the work of the Unit and the National Prion Clinic, its role in understanding and treating prion diseases and its contribution to the mission of the Medical Research Council.
Year(s) Of Engagement Activity 2019
 
Description Presentation at Prion 2019, Edmonton 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on "A perspective on prion strains and their significance" given at Prion 2019, Edmonton, Canada, an annual event for researchers involved in Prion diseases worldwide. Researchers gather together to inform and interact with others working in the prion field.
Year(s) Of Engagement Activity 2019
 
Description Presentation at the Keystone Symposia meeting on Neurodegenerative Diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on "Prion neurodegeneration: towards an effective treatment and its relevance for Alzheimer's disease" given at the Keystone Symposia meeting on Neurodegenerative Diseases: New Insights and Therapeutic Opportunities.The conference aimed to address the current state of knowledge in this emerging area and to provide advanced discussion of these topics between scientists from different fields of research and foster new collaborations that may lead to new therapeutic opportunities for those suffering from neurodegenerative diseases.
Year(s) Of Engagement Activity 2019
URL https://tks.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1653
 
Description Presentation to US Patient Group in Washington 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Patients, carers and/or patient groups
Results and Impact Presented talk to the CJD Foundation the US patient group.
Year(s) Of Engagement Activity 2017
 
Description School visit 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact workshop on healthy eating as part of the Royal Society of Biology's Biology Week
Year(s) Of Engagement Activity 2016
 
Description Seminar at Biogen on "Prion disease pathogenesis and therapeutics: wider relevance in Alzheimer's and other neurodegenerative conditions" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Seminar given on "Prion disease pathogenesis and therapeutics: wider relevance in Alzheimer's and other neurodegenerative conditions" at Biogen, Boston. Biogen is a global biotechnology company that develops innovative therapies for people living with serious neurological and neurodegenerative diseases.
Year(s) Of Engagement Activity 2019
 
Description Seminar at the John Innes Centre on "BSE, prion propagation and its wider relevance" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Seminar on "BSE, prion propagation and its wider relevance" given at the John Innes Centre to an audience that included a wide range of plant and microbial scientists from postgraduates to project leaders, chemists to molecular biologists and geneticists.The John Innes Centre is an independent, international centre of excellence in plant science, research, genetics and microbiology based in Norwich, UK.
Year(s) Of Engagement Activity 2019
 
Description school visit 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Gave a short talk about what scientists do then helped children demonstrate their science activity to year 6 children - St Mary's ans St John's CE School, Barnet
Year(s) Of Engagement Activity 2016