Role of Hippocampal Neurogenesis in Learning, Memory and Affective Behaviours
Lead Research Organisation:
University College London
Department Name: The Wolfson Inst for Biomedical Research
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Angelo M
(2006)
Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory.
in Journal of neurochemistry
Antunes-Martins A
(2007)
Sex-dependent up-regulation of two splicing factors, Psf and Srp20, during hippocampal memory formation.
in Learning & memory (Cold Spring Harbor, N.Y.)
Cacucci F
(2007)
Experience-dependent increase in CA1 place cell spatial information, but not spatial reproducibility, is dependent on the autophosphorylation of the alpha-isoform of the calcium/calmodulin-dependent protein kinase II.
in The Journal of neuroscience : the official journal of the Society for Neuroscience
Cole AR
(2007)
Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression.
in Journal of neurochemistry
Cooke SF
(2006)
Autophosphorylation of alphaCaMKII is not a general requirement for NMDA receptor-dependent LTP in the adult mouse.
in The Journal of physiology
Eickholt BJ
(2007)
Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase.
in PloS one
Engmann O
(2009)
Crosstalk between Cdk5 and GSK3beta: Implications for Alzheimer's Disease.
in Frontiers in molecular neuroscience
Giese KP
(2009)
GSK-3: a key player in neurodegeneration and memory.
in IUBMB life
Giese KP
(2007)
Novel insights into the beneficial and detrimental actions of cdk5.
in Molecular interventions
Hojjati MR
(2007)
Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses.
in Nature neuroscience
| Title | Camkk mutant mice |
| Description | These mutants are useful tools to investigate sex differences in memory formation |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2006 |
| Provided To Others? | Yes |
| Impact | Our research findings are fundamental for understanding sex differences in learning & memory in health and disease. |
| Description | Role of calcium/calmodulin kinase kinases in glucose metabolism |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Clinical Sciences Centre (CSC) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | provided CaMKK mutant mice |
| Collaborator Contribution | Our collaboration Prof. Dominc Withers established that there is no glucose metabolism phenotype in conditional CaMKK mutant mice |
| Impact | A publication resuylted from this work: Claret et al., 2011, Diabetes (PMID: 21266325). |