Pathfinder - Investigation of variant forms of COMT and their role in schizophrenia and mood disorders
Lead Research Organisation:
University of Oxford
Department Name: Pharmacology
Abstract
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Publications
Tunbridge EM
(2008)
Polymorphisms in the catechol-O-methyltransferase (COMT) gene influence plasma total homocysteine levels.
in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
Tunbridge EM
(2007)
Expression of multiple catechol-o-methyltransferase (COMT) mRNA variants in human brain.
in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
| Description | COMT polymorphisms and homocysteine levels. |
| Organisation | University of Oxford |
| Department | Department of Physiology, Anatomy and Genetics |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We worked with DPAG (Oxford University) to determine whether COMT polymorphisms had any affect on plasma homocysteine levels. COMT genotypes were determined in the OPTIMA cohort |
| Collaborator Contribution | Publication. New line of investigation concerning COMT and components of the methyltransferase systems in the brain. |
| Impact | Findings published: Polymorphisms in the catechol-O-methyltransferase (COMT) gene influence plasma total homocysteine levels. Tunbridge EM, Harrison PJ, Warden DR, Johnston C, Refsum H, Smith AD. Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 5;147B(6):996-9. |
| Start Year | 2006 |