Pathfinder - Investigation of variant forms of COMT and their role in schizophrenia and mood disorders

Lead Research Organisation: University of Oxford
Department Name: Pharmacology

Abstract

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Publications

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Tunbridge EM (2008) Polymorphisms in the catechol-O-methyltransferase (COMT) gene influence plasma total homocysteine levels. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

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Tunbridge EM (2007) Expression of multiple catechol-o-methyltransferase (COMT) mRNA variants in human brain. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

 
Description COMT polymorphisms and homocysteine levels. 
Organisation University of Oxford
Department Department of Physiology, Anatomy and Genetics
Country United Kingdom 
Sector Academic/University 
PI Contribution We worked with DPAG (Oxford University) to determine whether COMT polymorphisms had any affect on plasma homocysteine levels. COMT genotypes were determined in the OPTIMA cohort
Collaborator Contribution Publication. New line of investigation concerning COMT and components of the methyltransferase systems in the brain.
Impact Findings published: Polymorphisms in the catechol-O-methyltransferase (COMT) gene influence plasma total homocysteine levels. Tunbridge EM, Harrison PJ, Warden DR, Johnston C, Refsum H, Smith AD. Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 5;147B(6):996-9.
Start Year 2006