Pathfinder: Neurotrophic signalling in Motor Neurone Disease
Lead Research Organisation:
University of Sheffield
Department Name: Biomedical Science
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
De Vos KJ
(2007)
Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content.
in Human molecular genetics
De Vos KJ
(2008)
Role of axonal transport in neurodegenerative diseases.
in Annual review of neuroscience
Hewamadduma C
(2009)
New pedigrees and novel mutation expand the phenotype of REEP1-associated hereditary spastic paraplegia (HSP).
in Neurogenetics
Kasher PR
(2009)
Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.
in Journal of neurochemistry
| Description | project grant |
| Amount | £80,000 (GBP) |
| Organisation | Motor Neurone Disease Association (MND) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2009 |
| End | 06/2010 |
| Title | genetically modified zebrafish |
| Description | zebrafish bearing ENU-induced mutations in the alsin gene |
| Type Of Material | Model of mechanisms or symptoms - non-mammalian in vivo |
| Provided To Others? | No |
| Impact | Ongoing research using these fish |
| Description | MND care-givers conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Invited to give scientific presentation to a lay audience at a meeting discussions with patients and care givers feedback (2 way) |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009 |