Lymphostromal Interactions in Thymus Development and Function

Lead Research Organisation: University of Birmingham
Department Name: Health Service Management Centre

Abstract

The thymus gland plays an essential role in immunological protection against infection. It does this by supporting the production of T-lymphocytes, a type of white blood cell that is able to recognise and trigger the destruction of foreign materials entering the body. The purpose of this research is to understand how the thymus develops and supports the formation of T-cells from unspecialised blood stem cells. This will help to devise strategies to restore thymus function when this has been damaged or lost, to understand the origins of autoimmune disease which can occur when T-cell development goes wrong and to develop methods to produce T-cells in-vitro for therapeutic use.

As part of the Birmingham MRC Centre for Immune Regulation, the Groups research activities are listed on the Centre website. In addition, both PIs belong to the University Press Office panel of experts available for public consultation. Both visit schools in the locality and in their home town areas to speak to VI form groups on their work.

Technical Summary

The thymus plays an essential role in the development of T cells from haemopoietic progenitors and in the selection of the T cell antigen recognition repertoire. These processes involve a closely regulated programme of progenitor recruitment, proliferation, differentiation and selection regulated by interactions with stromal cells of the thymic microenvironment. The aim of this proposal is to investigate the factors regulating the development and function of this critical microenvironment and to gain a better understanding of the molecular regulation of T cell development and selection and the way in which stromal cells control these processes. This work will inform the development of strategies to restore or replace thymus function in ageing or following damage and will provide a basis to improve in vitro methods for the production of T cells for therapeutic applications.

Publications

10 25 50

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Anderson G (2007) Investigating central tolerance with reaggregate thymus organ cultures. in Methods in molecular biology (Clifton, N.J.)

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Anderson G (2007) Fetal thymus organ culture. in CSH protocols

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Anderson G (2007) Generating intrathymic microenvironments to establish T-cell tolerance. in Nature reviews. Immunology

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Anderson G (2008) Bringing the thymus to the bench. in Journal of immunology (Baltimore, Md. : 1950)

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Anderson G (2006) Establishment and functioning of intrathymic microenvironments. in Immunological reviews

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Anderson G (2014) Mechanisms of thymus medulla development and function. in Current topics in microbiology and immunology

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Anderson G (2009) A roadmap for thymic epithelial cell development. in European journal of immunology

 
Description 3 yr studentship - LAVR
Amount £75,000 (GBP)
Organisation Government of Mexico 
Sector Public
Country Mexico
Start 10/2010 
End 10/2012
 
Description 3 yr studentship - RB
Amount £50,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2008 
End 10/2011
 
Description 4 yr studentship - BL
Amount £70,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2010 
End 10/2014
 
Description 4 yr studentship - BYJ
Amount £75,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2009 
End 10/2013
 
Description 4 yr studentship - JC
Amount £70,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2009 
End 10/2013
 
Description 4 yr studentship - NR
Amount £70,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2006 
End 09/2010
 
Description Analysis of Notch Ligand Compartmentalisation in the thymus
Amount £1,360 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Christopher Buckley: Birmingham Experimental Arthritis Treatment Centre for Rheumatoid Arthritis
Amount £225,000 (GBP)
Funding ID 20015 
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description EU FP7 MC ITN -NINA: Neuroendocrine Immune Networks in Ageing.
Amount £665,082 (GBP)
Funding ID 238665 
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start  
 
Description MRC Centre for Musculoskeletal Ageing Research
Amount £1,227,858 (GBP)
Funding ID MR/K00414X/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 07/2012 
End 08/2017
 
Description MRC NIA (Cortical Thymic Epithelium: Defining Developmental Pathways and Specialisation for Positive Selection)
Amount £481,579 (GBP)
Funding ID G1001055 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description Mechanisms Regulating Development and Function of LTI
Amount £1,080 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Molecular and Cellular Regulation of T-Cell Development in the Thymus
Amount £3,000 (GBP)
Organisation The Nippon Foundation 
Sector Charity/Non Profit
Country Japan
Start  
 
Description Programme Grant
Amount £1,800,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description UK-Japan collaboration in medical research and health practice
Amount £12,000 (GBP)
Organisation The Nippon Foundation 
Sector Charity/Non Profit
Country Japan
Start  
 
Description VIP - KYOKO NAKAMURA
Amount £13,879 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Wellcome Trust Project Grant (Investigation of the role of Protein Kinase C (PKC) isoenzymes in the non-canonical Wnt signalling pathway during thymic epithelial cell developmentand differentiation)
Amount £43,876 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Title Thymus grafting 
Description In vivio model to determine the function of thymic epithelial cells 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2006 
Provided To Others? Yes  
Impact Several publications 
 
Description Arthritis Research UK Centre of Excellence Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure) 
Organisation Academic Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution The Birmingham hub will occupy the dedicated £8million laboratory/CRF space in the new Queen Elizabeth "super" hospital (http://www.uhb.nhs.uk/new-hospital.htm). This includes the MRC-ARUK Center for Musculoskeletal Ageing and the Experimental Arthritis Treatment Center (CB/JL). The IBR houses the MRC Center for Immune Regulation (PL/GA) and provides state-of-the-art technologies, such as high throughput sequencing, MoFlo cell sorting, through its Technology Hub. MRC Center for Immune Regulation: http://www.birmingham.ac.uk/research/ activity/mds/centres/mrcimmune/index.aspx / Systems Science for health. http:// www.birmingham.ac.uk/research/activity/ssfh/index.aspx/ Physical Sciences of Imaging in the Biomedical Sciences http://www.birmingham.ac.uk/research/ activity/psibs/index.aspx.
Collaborator Contribution The Glasgow hub in the Institute of Infection, Immunity and Inflammation (Director - IBM) will occupy the Glasgow Biomedical Research Centre (http://www.gla.ac.uk/departments/gbrc) a £17 million 'new build' containing 200 academic staff equipped with state-of-the art technology enabling molecular/cell biology including e.g. dedicated FACS Facility, high throughput screening, dedicated Imaging Centre, including a £1.5million investment in multi-photon imaging (PG/IBM), the recent £7 million investment in the Glasgow Polyomics Facility (http://www.gla.ac.uk/colleges/mvls/research/gpf/) that offers superb Systems Medicine and bioinformatics capabilities (lead by RB). GBRC hosts a EULAR Centre of Excellence. The Newcastle hub will reside in the Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) comprising some 180 research staff, and offering outstanding facilities for animal research include imaging, both small-bore MRI and PET (Newcastle Imaging Centre), cell biology, molecular biology, epigenetics, biochemistry and bioinformatics. The Musculoskeletal Research Group is a EULAR Centre of Excellence and houses ARUK Centres of Excellence in Tissue Engineering and Musculoskeletal Ageing. Translational research is focused in the Newcastle Clinical Research Facility (http://www.ncl.ac.uk/business/facilities/research/clinicalresearch.htm).
Impact Project being set up
Start Year 2012
 
Description Arthritis Research UK Centre of Excellence Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure) 
Organisation AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution The Birmingham hub will occupy the dedicated £8million laboratory/CRF space in the new Queen Elizabeth "super" hospital (http://www.uhb.nhs.uk/new-hospital.htm). This includes the MRC-ARUK Center for Musculoskeletal Ageing and the Experimental Arthritis Treatment Center (CB/JL). The IBR houses the MRC Center for Immune Regulation (PL/GA) and provides state-of-the-art technologies, such as high throughput sequencing, MoFlo cell sorting, through its Technology Hub. MRC Center for Immune Regulation: http://www.birmingham.ac.uk/research/ activity/mds/centres/mrcimmune/index.aspx / Systems Science for health. http:// www.birmingham.ac.uk/research/activity/ssfh/index.aspx/ Physical Sciences of Imaging in the Biomedical Sciences http://www.birmingham.ac.uk/research/ activity/psibs/index.aspx.
Collaborator Contribution The Glasgow hub in the Institute of Infection, Immunity and Inflammation (Director - IBM) will occupy the Glasgow Biomedical Research Centre (http://www.gla.ac.uk/departments/gbrc) a £17 million 'new build' containing 200 academic staff equipped with state-of-the art technology enabling molecular/cell biology including e.g. dedicated FACS Facility, high throughput screening, dedicated Imaging Centre, including a £1.5million investment in multi-photon imaging (PG/IBM), the recent £7 million investment in the Glasgow Polyomics Facility (http://www.gla.ac.uk/colleges/mvls/research/gpf/) that offers superb Systems Medicine and bioinformatics capabilities (lead by RB). GBRC hosts a EULAR Centre of Excellence. The Newcastle hub will reside in the Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) comprising some 180 research staff, and offering outstanding facilities for animal research include imaging, both small-bore MRI and PET (Newcastle Imaging Centre), cell biology, molecular biology, epigenetics, biochemistry and bioinformatics. The Musculoskeletal Research Group is a EULAR Centre of Excellence and houses ARUK Centres of Excellence in Tissue Engineering and Musculoskeletal Ageing. Translational research is focused in the Newcastle Clinical Research Facility (http://www.ncl.ac.uk/business/facilities/research/clinicalresearch.htm).
Impact Project being set up
Start Year 2012
 
Description Arthritis Research UK Centre of Excellence Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure) 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution The Birmingham hub will occupy the dedicated £8million laboratory/CRF space in the new Queen Elizabeth "super" hospital (http://www.uhb.nhs.uk/new-hospital.htm). This includes the MRC-ARUK Center for Musculoskeletal Ageing and the Experimental Arthritis Treatment Center (CB/JL). The IBR houses the MRC Center for Immune Regulation (PL/GA) and provides state-of-the-art technologies, such as high throughput sequencing, MoFlo cell sorting, through its Technology Hub. MRC Center for Immune Regulation: http://www.birmingham.ac.uk/research/ activity/mds/centres/mrcimmune/index.aspx / Systems Science for health. http:// www.birmingham.ac.uk/research/activity/ssfh/index.aspx/ Physical Sciences of Imaging in the Biomedical Sciences http://www.birmingham.ac.uk/research/ activity/psibs/index.aspx.
Collaborator Contribution The Glasgow hub in the Institute of Infection, Immunity and Inflammation (Director - IBM) will occupy the Glasgow Biomedical Research Centre (http://www.gla.ac.uk/departments/gbrc) a £17 million 'new build' containing 200 academic staff equipped with state-of-the art technology enabling molecular/cell biology including e.g. dedicated FACS Facility, high throughput screening, dedicated Imaging Centre, including a £1.5million investment in multi-photon imaging (PG/IBM), the recent £7 million investment in the Glasgow Polyomics Facility (http://www.gla.ac.uk/colleges/mvls/research/gpf/) that offers superb Systems Medicine and bioinformatics capabilities (lead by RB). GBRC hosts a EULAR Centre of Excellence. The Newcastle hub will reside in the Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) comprising some 180 research staff, and offering outstanding facilities for animal research include imaging, both small-bore MRI and PET (Newcastle Imaging Centre), cell biology, molecular biology, epigenetics, biochemistry and bioinformatics. The Musculoskeletal Research Group is a EULAR Centre of Excellence and houses ARUK Centres of Excellence in Tissue Engineering and Musculoskeletal Ageing. Translational research is focused in the Newcastle Clinical Research Facility (http://www.ncl.ac.uk/business/facilities/research/clinicalresearch.htm).
Impact Project being set up
Start Year 2012
 
Description Arthritis Research UK Centre of Excellence Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure) 
Organisation Harvard University
Country United States 
Sector Academic/University 
PI Contribution The Birmingham hub will occupy the dedicated £8million laboratory/CRF space in the new Queen Elizabeth "super" hospital (http://www.uhb.nhs.uk/new-hospital.htm). This includes the MRC-ARUK Center for Musculoskeletal Ageing and the Experimental Arthritis Treatment Center (CB/JL). The IBR houses the MRC Center for Immune Regulation (PL/GA) and provides state-of-the-art technologies, such as high throughput sequencing, MoFlo cell sorting, through its Technology Hub. MRC Center for Immune Regulation: http://www.birmingham.ac.uk/research/ activity/mds/centres/mrcimmune/index.aspx / Systems Science for health. http:// www.birmingham.ac.uk/research/activity/ssfh/index.aspx/ Physical Sciences of Imaging in the Biomedical Sciences http://www.birmingham.ac.uk/research/ activity/psibs/index.aspx.
Collaborator Contribution The Glasgow hub in the Institute of Infection, Immunity and Inflammation (Director - IBM) will occupy the Glasgow Biomedical Research Centre (http://www.gla.ac.uk/departments/gbrc) a £17 million 'new build' containing 200 academic staff equipped with state-of-the art technology enabling molecular/cell biology including e.g. dedicated FACS Facility, high throughput screening, dedicated Imaging Centre, including a £1.5million investment in multi-photon imaging (PG/IBM), the recent £7 million investment in the Glasgow Polyomics Facility (http://www.gla.ac.uk/colleges/mvls/research/gpf/) that offers superb Systems Medicine and bioinformatics capabilities (lead by RB). GBRC hosts a EULAR Centre of Excellence. The Newcastle hub will reside in the Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) comprising some 180 research staff, and offering outstanding facilities for animal research include imaging, both small-bore MRI and PET (Newcastle Imaging Centre), cell biology, molecular biology, epigenetics, biochemistry and bioinformatics. The Musculoskeletal Research Group is a EULAR Centre of Excellence and houses ARUK Centres of Excellence in Tissue Engineering and Musculoskeletal Ageing. Translational research is focused in the Newcastle Clinical Research Facility (http://www.ncl.ac.uk/business/facilities/research/clinicalresearch.htm).
Impact Project being set up
Start Year 2012
 
Description Arthritis Research UK Centre of Excellence Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure) 
Organisation MedImmune
Country United States 
Sector Private 
PI Contribution The Birmingham hub will occupy the dedicated £8million laboratory/CRF space in the new Queen Elizabeth "super" hospital (http://www.uhb.nhs.uk/new-hospital.htm). This includes the MRC-ARUK Center for Musculoskeletal Ageing and the Experimental Arthritis Treatment Center (CB/JL). The IBR houses the MRC Center for Immune Regulation (PL/GA) and provides state-of-the-art technologies, such as high throughput sequencing, MoFlo cell sorting, through its Technology Hub. MRC Center for Immune Regulation: http://www.birmingham.ac.uk/research/ activity/mds/centres/mrcimmune/index.aspx / Systems Science for health. http:// www.birmingham.ac.uk/research/activity/ssfh/index.aspx/ Physical Sciences of Imaging in the Biomedical Sciences http://www.birmingham.ac.uk/research/ activity/psibs/index.aspx.
Collaborator Contribution The Glasgow hub in the Institute of Infection, Immunity and Inflammation (Director - IBM) will occupy the Glasgow Biomedical Research Centre (http://www.gla.ac.uk/departments/gbrc) a £17 million 'new build' containing 200 academic staff equipped with state-of-the art technology enabling molecular/cell biology including e.g. dedicated FACS Facility, high throughput screening, dedicated Imaging Centre, including a £1.5million investment in multi-photon imaging (PG/IBM), the recent £7 million investment in the Glasgow Polyomics Facility (http://www.gla.ac.uk/colleges/mvls/research/gpf/) that offers superb Systems Medicine and bioinformatics capabilities (lead by RB). GBRC hosts a EULAR Centre of Excellence. The Newcastle hub will reside in the Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) comprising some 180 research staff, and offering outstanding facilities for animal research include imaging, both small-bore MRI and PET (Newcastle Imaging Centre), cell biology, molecular biology, epigenetics, biochemistry and bioinformatics. The Musculoskeletal Research Group is a EULAR Centre of Excellence and houses ARUK Centres of Excellence in Tissue Engineering and Musculoskeletal Ageing. Translational research is focused in the Newcastle Clinical Research Facility (http://www.ncl.ac.uk/business/facilities/research/clinicalresearch.htm).
Impact Project being set up
Start Year 2012
 
Description Arthritis Research UK Centre of Excellence Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure) 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution The Birmingham hub will occupy the dedicated £8million laboratory/CRF space in the new Queen Elizabeth "super" hospital (http://www.uhb.nhs.uk/new-hospital.htm). This includes the MRC-ARUK Center for Musculoskeletal Ageing and the Experimental Arthritis Treatment Center (CB/JL). The IBR houses the MRC Center for Immune Regulation (PL/GA) and provides state-of-the-art technologies, such as high throughput sequencing, MoFlo cell sorting, through its Technology Hub. MRC Center for Immune Regulation: http://www.birmingham.ac.uk/research/ activity/mds/centres/mrcimmune/index.aspx / Systems Science for health. http:// www.birmingham.ac.uk/research/activity/ssfh/index.aspx/ Physical Sciences of Imaging in the Biomedical Sciences http://www.birmingham.ac.uk/research/ activity/psibs/index.aspx.
Collaborator Contribution The Glasgow hub in the Institute of Infection, Immunity and Inflammation (Director - IBM) will occupy the Glasgow Biomedical Research Centre (http://www.gla.ac.uk/departments/gbrc) a £17 million 'new build' containing 200 academic staff equipped with state-of-the art technology enabling molecular/cell biology including e.g. dedicated FACS Facility, high throughput screening, dedicated Imaging Centre, including a £1.5million investment in multi-photon imaging (PG/IBM), the recent £7 million investment in the Glasgow Polyomics Facility (http://www.gla.ac.uk/colleges/mvls/research/gpf/) that offers superb Systems Medicine and bioinformatics capabilities (lead by RB). GBRC hosts a EULAR Centre of Excellence. The Newcastle hub will reside in the Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) comprising some 180 research staff, and offering outstanding facilities for animal research include imaging, both small-bore MRI and PET (Newcastle Imaging Centre), cell biology, molecular biology, epigenetics, biochemistry and bioinformatics. The Musculoskeletal Research Group is a EULAR Centre of Excellence and houses ARUK Centres of Excellence in Tissue Engineering and Musculoskeletal Ageing. Translational research is focused in the Newcastle Clinical Research Facility (http://www.ncl.ac.uk/business/facilities/research/clinicalresearch.htm).
Impact Project being set up
Start Year 2012
 
Description Arthritis Research UK Centre of Excellence Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure) 
Organisation Pfizer Ltd
Country United Kingdom 
Sector Private 
PI Contribution The Birmingham hub will occupy the dedicated £8million laboratory/CRF space in the new Queen Elizabeth "super" hospital (http://www.uhb.nhs.uk/new-hospital.htm). This includes the MRC-ARUK Center for Musculoskeletal Ageing and the Experimental Arthritis Treatment Center (CB/JL). The IBR houses the MRC Center for Immune Regulation (PL/GA) and provides state-of-the-art technologies, such as high throughput sequencing, MoFlo cell sorting, through its Technology Hub. MRC Center for Immune Regulation: http://www.birmingham.ac.uk/research/ activity/mds/centres/mrcimmune/index.aspx / Systems Science for health. http:// www.birmingham.ac.uk/research/activity/ssfh/index.aspx/ Physical Sciences of Imaging in the Biomedical Sciences http://www.birmingham.ac.uk/research/ activity/psibs/index.aspx.
Collaborator Contribution The Glasgow hub in the Institute of Infection, Immunity and Inflammation (Director - IBM) will occupy the Glasgow Biomedical Research Centre (http://www.gla.ac.uk/departments/gbrc) a £17 million 'new build' containing 200 academic staff equipped with state-of-the art technology enabling molecular/cell biology including e.g. dedicated FACS Facility, high throughput screening, dedicated Imaging Centre, including a £1.5million investment in multi-photon imaging (PG/IBM), the recent £7 million investment in the Glasgow Polyomics Facility (http://www.gla.ac.uk/colleges/mvls/research/gpf/) that offers superb Systems Medicine and bioinformatics capabilities (lead by RB). GBRC hosts a EULAR Centre of Excellence. The Newcastle hub will reside in the Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) comprising some 180 research staff, and offering outstanding facilities for animal research include imaging, both small-bore MRI and PET (Newcastle Imaging Centre), cell biology, molecular biology, epigenetics, biochemistry and bioinformatics. The Musculoskeletal Research Group is a EULAR Centre of Excellence and houses ARUK Centres of Excellence in Tissue Engineering and Musculoskeletal Ageing. Translational research is focused in the Newcastle Clinical Research Facility (http://www.ncl.ac.uk/business/facilities/research/clinicalresearch.htm).
Impact Project being set up
Start Year 2012
 
Description Arthritis Research UK Centre of Excellence Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure) 
Organisation University of California, Berkeley
Country United States 
Sector Academic/University 
PI Contribution The Birmingham hub will occupy the dedicated £8million laboratory/CRF space in the new Queen Elizabeth "super" hospital (http://www.uhb.nhs.uk/new-hospital.htm). This includes the MRC-ARUK Center for Musculoskeletal Ageing and the Experimental Arthritis Treatment Center (CB/JL). The IBR houses the MRC Center for Immune Regulation (PL/GA) and provides state-of-the-art technologies, such as high throughput sequencing, MoFlo cell sorting, through its Technology Hub. MRC Center for Immune Regulation: http://www.birmingham.ac.uk/research/ activity/mds/centres/mrcimmune/index.aspx / Systems Science for health. http:// www.birmingham.ac.uk/research/activity/ssfh/index.aspx/ Physical Sciences of Imaging in the Biomedical Sciences http://www.birmingham.ac.uk/research/ activity/psibs/index.aspx.
Collaborator Contribution The Glasgow hub in the Institute of Infection, Immunity and Inflammation (Director - IBM) will occupy the Glasgow Biomedical Research Centre (http://www.gla.ac.uk/departments/gbrc) a £17 million 'new build' containing 200 academic staff equipped with state-of-the art technology enabling molecular/cell biology including e.g. dedicated FACS Facility, high throughput screening, dedicated Imaging Centre, including a £1.5million investment in multi-photon imaging (PG/IBM), the recent £7 million investment in the Glasgow Polyomics Facility (http://www.gla.ac.uk/colleges/mvls/research/gpf/) that offers superb Systems Medicine and bioinformatics capabilities (lead by RB). GBRC hosts a EULAR Centre of Excellence. The Newcastle hub will reside in the Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) comprising some 180 research staff, and offering outstanding facilities for animal research include imaging, both small-bore MRI and PET (Newcastle Imaging Centre), cell biology, molecular biology, epigenetics, biochemistry and bioinformatics. The Musculoskeletal Research Group is a EULAR Centre of Excellence and houses ARUK Centres of Excellence in Tissue Engineering and Musculoskeletal Ageing. Translational research is focused in the Newcastle Clinical Research Facility (http://www.ncl.ac.uk/business/facilities/research/clinicalresearch.htm).
Impact Project being set up
Start Year 2012
 
Description Arthritis Research UK Centre of Excellence Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure) 
Organisation University of Glasgow
Department Institute of Infection, Immunity and Inflammation
Country United Kingdom 
Sector Academic/University 
PI Contribution The Birmingham hub will occupy the dedicated £8million laboratory/CRF space in the new Queen Elizabeth "super" hospital (http://www.uhb.nhs.uk/new-hospital.htm). This includes the MRC-ARUK Center for Musculoskeletal Ageing and the Experimental Arthritis Treatment Center (CB/JL). The IBR houses the MRC Center for Immune Regulation (PL/GA) and provides state-of-the-art technologies, such as high throughput sequencing, MoFlo cell sorting, through its Technology Hub. MRC Center for Immune Regulation: http://www.birmingham.ac.uk/research/ activity/mds/centres/mrcimmune/index.aspx / Systems Science for health. http:// www.birmingham.ac.uk/research/activity/ssfh/index.aspx/ Physical Sciences of Imaging in the Biomedical Sciences http://www.birmingham.ac.uk/research/ activity/psibs/index.aspx.
Collaborator Contribution The Glasgow hub in the Institute of Infection, Immunity and Inflammation (Director - IBM) will occupy the Glasgow Biomedical Research Centre (http://www.gla.ac.uk/departments/gbrc) a £17 million 'new build' containing 200 academic staff equipped with state-of-the art technology enabling molecular/cell biology including e.g. dedicated FACS Facility, high throughput screening, dedicated Imaging Centre, including a £1.5million investment in multi-photon imaging (PG/IBM), the recent £7 million investment in the Glasgow Polyomics Facility (http://www.gla.ac.uk/colleges/mvls/research/gpf/) that offers superb Systems Medicine and bioinformatics capabilities (lead by RB). GBRC hosts a EULAR Centre of Excellence. The Newcastle hub will reside in the Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) comprising some 180 research staff, and offering outstanding facilities for animal research include imaging, both small-bore MRI and PET (Newcastle Imaging Centre), cell biology, molecular biology, epigenetics, biochemistry and bioinformatics. The Musculoskeletal Research Group is a EULAR Centre of Excellence and houses ARUK Centres of Excellence in Tissue Engineering and Musculoskeletal Ageing. Translational research is focused in the Newcastle Clinical Research Facility (http://www.ncl.ac.uk/business/facilities/research/clinicalresearch.htm).
Impact Project being set up
Start Year 2012
 
Description Arthritis Research UK Centre of Excellence Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure) 
Organisation University of Zurich
Country Switzerland 
Sector Academic/University 
PI Contribution The Birmingham hub will occupy the dedicated £8million laboratory/CRF space in the new Queen Elizabeth "super" hospital (http://www.uhb.nhs.uk/new-hospital.htm). This includes the MRC-ARUK Center for Musculoskeletal Ageing and the Experimental Arthritis Treatment Center (CB/JL). The IBR houses the MRC Center for Immune Regulation (PL/GA) and provides state-of-the-art technologies, such as high throughput sequencing, MoFlo cell sorting, through its Technology Hub. MRC Center for Immune Regulation: http://www.birmingham.ac.uk/research/ activity/mds/centres/mrcimmune/index.aspx / Systems Science for health. http:// www.birmingham.ac.uk/research/activity/ssfh/index.aspx/ Physical Sciences of Imaging in the Biomedical Sciences http://www.birmingham.ac.uk/research/ activity/psibs/index.aspx.
Collaborator Contribution The Glasgow hub in the Institute of Infection, Immunity and Inflammation (Director - IBM) will occupy the Glasgow Biomedical Research Centre (http://www.gla.ac.uk/departments/gbrc) a £17 million 'new build' containing 200 academic staff equipped with state-of-the art technology enabling molecular/cell biology including e.g. dedicated FACS Facility, high throughput screening, dedicated Imaging Centre, including a £1.5million investment in multi-photon imaging (PG/IBM), the recent £7 million investment in the Glasgow Polyomics Facility (http://www.gla.ac.uk/colleges/mvls/research/gpf/) that offers superb Systems Medicine and bioinformatics capabilities (lead by RB). GBRC hosts a EULAR Centre of Excellence. The Newcastle hub will reside in the Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) comprising some 180 research staff, and offering outstanding facilities for animal research include imaging, both small-bore MRI and PET (Newcastle Imaging Centre), cell biology, molecular biology, epigenetics, biochemistry and bioinformatics. The Musculoskeletal Research Group is a EULAR Centre of Excellence and houses ARUK Centres of Excellence in Tissue Engineering and Musculoskeletal Ageing. Translational research is focused in the Newcastle Clinical Research Facility (http://www.ncl.ac.uk/business/facilities/research/clinicalresearch.htm).
Impact Project being set up
Start Year 2012
 
Description Arthritis Research UK Centre of Excellence Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure) 
Organisation Versus Arthritis
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution The Birmingham hub will occupy the dedicated £8million laboratory/CRF space in the new Queen Elizabeth "super" hospital (http://www.uhb.nhs.uk/new-hospital.htm). This includes the MRC-ARUK Center for Musculoskeletal Ageing and the Experimental Arthritis Treatment Center (CB/JL). The IBR houses the MRC Center for Immune Regulation (PL/GA) and provides state-of-the-art technologies, such as high throughput sequencing, MoFlo cell sorting, through its Technology Hub. MRC Center for Immune Regulation: http://www.birmingham.ac.uk/research/ activity/mds/centres/mrcimmune/index.aspx / Systems Science for health. http:// www.birmingham.ac.uk/research/activity/ssfh/index.aspx/ Physical Sciences of Imaging in the Biomedical Sciences http://www.birmingham.ac.uk/research/ activity/psibs/index.aspx.
Collaborator Contribution The Glasgow hub in the Institute of Infection, Immunity and Inflammation (Director - IBM) will occupy the Glasgow Biomedical Research Centre (http://www.gla.ac.uk/departments/gbrc) a £17 million 'new build' containing 200 academic staff equipped with state-of-the art technology enabling molecular/cell biology including e.g. dedicated FACS Facility, high throughput screening, dedicated Imaging Centre, including a £1.5million investment in multi-photon imaging (PG/IBM), the recent £7 million investment in the Glasgow Polyomics Facility (http://www.gla.ac.uk/colleges/mvls/research/gpf/) that offers superb Systems Medicine and bioinformatics capabilities (lead by RB). GBRC hosts a EULAR Centre of Excellence. The Newcastle hub will reside in the Institute of Cellular Medicine (http://www.ncl.ac.uk/icm/) comprising some 180 research staff, and offering outstanding facilities for animal research include imaging, both small-bore MRI and PET (Newcastle Imaging Centre), cell biology, molecular biology, epigenetics, biochemistry and bioinformatics. The Musculoskeletal Research Group is a EULAR Centre of Excellence and houses ARUK Centres of Excellence in Tissue Engineering and Musculoskeletal Ageing. Translational research is focused in the Newcastle Clinical Research Facility (http://www.ncl.ac.uk/business/facilities/research/clinicalresearch.htm).
Impact Project being set up
Start Year 2012
 
Description Ephrin signalling and T Cell development 
Organisation Autonomous University of Madrid
Country Spain 
Sector Academic/University 
PI Contribution Using novel reagents to block ephrin signalling in thymus organ cultures
Collaborator Contribution Provision of novel reagents
Impact following publication 17668899
Start Year 2006
 
Description MRC Centre for Immune Regulation 
Organisation University of Birmingham
Department MRC Centre for Immune Regulation
Country United Kingdom 
Sector Academic/University 
PI Contribution Theme Lead Looking at Mechanisms in lymphocyte development and selection
Collaborator Contribution Provision of core facilities
Impact All the outputs on this form can be attributed to MRC Centre for Immune Regulation
 
Description Redefining epithelial thymic progenitors 
Organisation Monash University
Country Australia 
Sector Academic/University 
PI Contribution Use of novel reagents to redefine thymic epithelial development
Collaborator Contribution Provision of novel reagents
Impact Following publication 17694573
Start Year 2006
 
Description Regulation of AIRE function in thymic epithelium 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Systems to induce AIRE expression via RANK signalling
Collaborator Contribution Molecular analysis of AIRE function
Impact following publication 17974569
Start Year 2007
 
Description Regulation of thymocyte positive selection 
Organisation National Institutes of Health (NIH)
Country United States 
Sector Public 
PI Contribution Providing training in in vitro systems of T cell development
Collaborator Contribution Using our in house in vitro techniques to study thymic selection
Impact Following publication 18684012
Start Year 2007
 
Description TNF Receptors in T Cell Development 
Organisation University of Birmingham
Department College of Medical and Dental Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution analysis of T cell development in mice lacking TNF receptors
Collaborator Contribution Provision of genetically manipulated mice
Impact Following joint publications 17992179 and 17502664
Start Year 2007
 
Description Demonstrators on the STEMNET stand at the Big Bang Fair 2014 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Sonia Parnell and others from Graham Anderson's Immunology research Group had a very fulfilling time volunteering as activity demonstrators on the STEMNET stand at the Big Bang Fair 2014 recently. The investigative activities were family-focused and suitable for pre-schoolers through to adults. Sonia said she "found it a brilliant opportunity introducing young minds to scientific investigations".




Over the past two years the Anderson/Jenkinson lab have organised 12 work placements in their laboratories in conjunction with King Edward VI and other secondary schools. This has been done in close partnership Julia Kingston, STEM Coordinator at the University of Birmingham STEM Centre. After the placements, Julia commented:

"Your students had a great experience. You and your group are doing a great job. Experiencing the actual lab environment is something they will never forget and it will certainly help them make up their minds [on a scientific career]."

Feedback from a sixth form student who undertook a lab placement wrote ""Thanks for the amazing experience.it gave me some food for thought about my EPQ (Extended Project Qualifications) research"
Year(s) Of Engagement Activity 2014
 
Description Meeting with Patient representative and fund raising group for Arthritis Research 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact Met with patient representative leaders and leading fundraisers locally to promote support for research in the MRC Centre.

not yet known/
Year(s) Of Engagement Activity 2010
 
Description School Visit 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact 30 sixth form pupils attended talk on immunology and possible related career options and discussions with individual students

Not yet known
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010,2011
 
Description WI talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Group of 40 people attended talk on how medical research works and is funded.

Not yet known
Year(s) Of Engagement Activity 2010,2011