Transgenic control of adrenocorticosteroid synthesis

Lead Research Organisation: University of Edinburgh
Department Name: Centre for Molecular Medicine


Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.


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Michailidou Z (2008) Glucocorticoid receptor haploinsufficiency causes hypertension and attenuates hypothalamic-pituitary-adrenal axis and blood pressure adaptions to high-fat diet. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology

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Mullins LJ (2009) Cyp11b1 null mouse, a model of congenital adrenal hyperplasia. in The Journal of biological chemistry

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O'Reilly M (2006) Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo. in Journal of the American Society of Nephrology : JASN

Description MRC Bridging Support
Amount £70,600 (GBP)
Funding ID G0701528 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 06/2007 
End 06/2008
Title Mouse Model of Congenital Adrenal Hyperplasia 
Description Genetically modified Cyp11b1 null mouse 
Type Of Material Model of mechanisms or symptoms - non-mammalian in vivo 
Provided To Others? No  
Impact Novel aspects of phenotype relevant to problems of fertility, cardiovascular disease and central nervous system 
Title kidney microarray database 
Description Effects of ACTH on kidney gene expression ArrayExpress database express Accession No: E-MEXP-1761 
Type Of Material Biological samples 
Year Produced 2009 
Provided To Others? Yes  
Impact Publication (19920212)