Transgenic control of adrenocorticosteroid synthesis
Lead Research Organisation:
University of Edinburgh
Department Name: Centre for Molecular Medicine
Abstract
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Publications
Hadoke PW
(2006)
Altered vascular contractility in adult female rats with hypertension programmed by prenatal glucocorticoid exposure.
in The Journal of endocrinology
Lai M
(2007)
Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia.
in The European journal of neuroscience
Michailidou Z
(2007)
Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone.
in The Journal of endocrinology
Michailidou Z
(2008)
Glucocorticoid receptor haploinsufficiency causes hypertension and attenuates hypothalamic-pituitary-adrenal axis and blood pressure adaptions to high-fat diet.
in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Mullins LJ
(2009)
Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.
in The Journal of biological chemistry
O'Regan D
(2008)
Prenatal dexamethasone 'programmes' hypotension, but stress-induced hypertension in adult offspring.
in The Journal of endocrinology
O'Reilly M
(2006)
Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo.
in Journal of the American Society of Nephrology : JASN
| Description | MRC Bridging Support |
| Amount | £70,600 (GBP) |
| Funding ID | G0701528 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2007 |
| End | 06/2008 |
| Title | Mouse Model of Congenital Adrenal Hyperplasia |
| Description | Genetically modified Cyp11b1 null mouse |
| Type Of Material | Model of mechanisms or symptoms - non-mammalian in vivo |
| Provided To Others? | No |
| Impact | Novel aspects of phenotype relevant to problems of fertility, cardiovascular disease and central nervous system |
| Title | kidney microarray database |
| Description | Effects of ACTH on kidney gene expression ArrayExpress database www.ebi.ac.uk/array express Accession No: E-MEXP-1761 |
| Type Of Material | Biological samples |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | Publication (19920212) |