Developing statistical methods to meet the demands of experimental geonomics
Lead Research Organisation:
University of Oxford
Department Name: Statistics
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Agam A
(2010)
Elusive copy number variation in the mouse genome.
in PloS one
Anjum S
(2009)
A boosting approach to structure learning of graphs with and without prior knowledge.
in Bioinformatics (Oxford, England)
Antonyuk A
(2009)
On testing for genetic association in case-control studies when population allele frequencies are known.
in Genetic epidemiology
Cardin N
(2011)
Bayesian hierarchical mixture modeling to assign copy number from a targeted CNV array.
in Genetic epidemiology
Chittenden TW
(2010)
Therapeutic implications of GIPC1 silencing in cancer.
in PloS one
Colella S
(2007)
QuantiSNP: an Objective Bayes Hidden-Markov Model to detect and accurately map copy number variation using SNP genotyping data.
in Nucleic acids research
Davies JL
(2010)
Detecting interacting genetic loci with effects on quantitative traits where the nature and order of the interaction are unknown.
in Genetic epidemiology
De Wet H
(2006)
Modulation of the BK channel by estrogens: examination at single channel level.
in Molecular membrane biology
Giannoulatou E
(2008)
GenoSNP: a variational Bayes within-sample SNP genotyping algorithm that does not require a reference population.
in Bioinformatics (Oxford, England)
| Description | CHIBCHA FP7 grant |
| Amount | £400,000 (GBP) |
| Organisation | European Commission |
| Department | Seventh Framework Programme (FP7) |
| Sector | Public |
| Country | European Union (EU) |
| Start | 06/2009 |
| End | 02/2013 |
| Description | Health Innovation Challenge Fund (Joint Wellcome Trust and DH initiative) |
| Amount | £366,383 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2011 |
| End | 01/2014 |
| Description | Health Innovation Challenge Fund (Joint Wellcome Trust and DH initiative) |
| Amount | £366,383 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2011 |
| End | 01/2014 |
| Title | oncosnp |
| Description | a novel statistical method for inferring copy number alterations in cancer genomes |
| Type Of Material | Data analysis technique |
| Year Produced | 2010 |
| Provided To Others? | Yes |
| Impact | we have published the method in "Genome Biology". A number of international labs are using the technique |
| Title | quantisnp |
| Description | We have developed a number of algorithms and software packages for the analysis of high-throughput genomic data |
| Type Of Material | Data analysis technique |
| Year Produced | 2008 |
| Provided To Others? | Yes |
| Impact | Our algorithms are being used by research labs throughout the world |
| Description | Investigation of structural variation in tumours |
| Organisation | Ludwig Institute for Cancer Research |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I was involved in developing statistical methods for the analysis of structural variation in cancer samples |
| Collaborator Contribution | The collaboration has lead to some new research ideas which we are following up. |
| Impact | We are currently writing up our findings Oliver is a cancer genetist and I am a biostatistician |
| Start Year | 2009 |