Functional Connectivity of the motor system in healthy subjects and in patients with movement disorders or stroke

Lead Research Organisation: University College London
Department Name: Unknown

Abstract

Research progress will be posted on the Sobell Department page in the Institute of Neurology website. Major advances will be communicated to the public with the help of the UCL Media Relations Office. In addition we will compete (as in previous years) for space at public events such as the Royal Society Summer Exibition.

Technical Summary

The distributed organisation of the brain means that damage or disease in any one part has effects on the function of many other connected parts. This is a proposal to develop a new generation of methodologies to investigate functional connectivity in the human brain. We will then use them to test hypotheses about how reorganisation of the system contributes to symptoms in patients with disorders of movement such as Parkinson?s disease or stroke.

Transcranial methods of brain stimulation can produce temporary disruption in localised brain areas and our recent work shows that this leads to reorganisation of functional connectivity that resembles that seen in some patients after stroke. This proposal extends this approach in two ways. First we will improve our measures of functional connectivity by using paired pulse designs of transcranial magnetic stimulation (TMS) and combined TMS/fMRI to probe the time course and patterns of such changes in healthy brain. Second we will improve existing methods of transient disruption with our novel method of ?theta burst? TMS that can produce very rapid and local changes in brain function. Together this will allow us to investigate patterns of reorganisation can be influenced by training or pharmacological interventions. Parallel studies in patients with disorders of movement will provide information on patterns of reorganisation (and its time course) in chronic disease.

Publications

10 25 50
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Avanzino L (2007) Intracortical circuits modulate transcallosal inhibition in humans. in The Journal of physiology

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Bäumer T (2009) Inhibitory and facilitatory connectivity from ventral premotor to primary motor cortex in healthy humans at rest--a bifocal TMS study. in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

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Del Olmo MF (2007) Role of the cerebellum in externally paced rhythmic finger movements. in Journal of neurophysiology

 
Description EC FP7 funding
Amount £250,000 (GBP)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 01/2009 
End 12/2013
 
Description EC FP7 funding
Amount £280,000 (GBP)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 01/2009 
End 12/2013
 
Description International collaborations
Amount £25,000 (GBP)
Organisation The Royal Society 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2012 
End 05/2014
 
Description Driver 
Organisation Wellcome Trust
Department Wellcome Trust Cente for Neuroimaging
Country United Kingdom 
Sector Academic/University 
PI Contribution provision of expertiseon TMS methods
Collaborator Contribution intellectual input on parietal cortex connectivity to motor cortex
Impact see publications
Start Year 2006
 
Description journalist interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact preparation of newspapaer and magazine articles

emails from listeners
Year(s) Of Engagement Activity 2006,2007