Early Detection and psychological intervention for individuals at high risk of psychosis

Lead Research Organisation: University of Manchester
Department Name: Medical and Human Sciences


Psychotic disorders such as schizophrenia affect approximately 1 in 100 people, and can be severely disabling, causing people to spend large periods of their lives socially isolated and economically non-productive. Approximately 10% of patients with psychosis commit suicide, and psychotic disorders create a considerable burden on health service resources. Recently, some studies have examined the possibility of finding people who are at high risk of developing psychosis (leading to diagnoses such as schizophrenia) for the first time. This opens up the prospect of preventing or delaying schizophrenia, the most disabling of the psychiatric disorders. This project aims to find such a sample of people at high-risk, who are distressed and help-seeking because of incipient or attenuated symptoms, and to evaluate the effectiveness of a psychological treatment in preventing or delaying the development of psychosis, or in making psychosis less severe should it occur. This will be done by comparing the psychological treatment (cognitive therapy) and regular monitoring of patients? mental state with monitoring of mental state alone. The monitoring will involve measures of psychotic experiences (such as hearing voices and unusual beliefs), distress and a person?s diagnosis. We will examine whether the psychological treatment leads to improvements in patient?s health and reductions in the need for and use of health and social care services. This project aims to influence the future provision of mental health services; if we achieve positive results we expect our treatment to become standard in the NHS. The demonstration that psychosis is preventable will have enormous implications because of the considerable personal, economic and social costs of this disorder. Such a demonstration should also help to reduce the stigma experienced by psychotic patients and their families. We will therefore aim to communicate our findings not only to our professional colleagues (through articles in professional journals) but also to the general public. We have experience of educating the general public about mental illness. Many of the grant holders have given talks to general audiences, one (RPB) has written a popular science book about psychosis, and three (TM, RPB and PF) are writing a self-help book for psychotic patients.

Technical Summary

Recent studies have demonstrated the feasibility of detecting individuals who are at high risk of developing psychosis for the first time. Building on our successful single-site trial, we will identify a sample of help-seeking individuals operationally defined as at high-risk of psychosis and evaluate the effectiveness of a psychological treatment (cognitive therapy) designed to prevent or delay the onset of illness, and reduce the severity of symptoms should they occur. Our multi-site randomised controlled trial will compare cognitive therapy plus regular monitoring of mental state with regular monitoring alone. The primary outcome will be transition to DSM-IV defined psychosis, which we hope to prevent. Secondary measures of symptoms, distress and non-psychotic psychopathology will be recorded and outcomes will be assessed over a variable length follow-up period (6 months to 2 years). An economic analysis will examine whether psychological treatment leads to reductions in the use of formal and informal health and social care services.


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Flach C (2015) Components of therapy as mechanisms of change in cognitive therapy for people at risk of psychosis: analysis of the EDIE-2 trial. in The British journal of psychiatry : the journal of mental science

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Morrison AP (2013) Impact of cognitive therapy on internalised stigma in people with at-risk mental states. in The British journal of psychiatry : the journal of mental science

Guideline Title NICE CG155 and CG178
Description Inclusion in NICE guideline evidence review
Geographic Reach National 
Policy Influence Type Citation in clinical guidelines
Impact The NICE guideline led to development of access and waiting standards that include access to cbt for people at high risk of psychosis
Guideline Title Psychosis and Schizophrenia in children and young people
Description NICE guidance
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical guidelines
Impact There is now an NHS standard for care which requires people who are at risk of psychosis to receive evidence based services including CBT
URL http://www.nice.org.uk/CG155
Description membership of NICE GDG
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee