Models for assessment of arrhythmogenicity after gene or cell transfer

Lead Research Organisation: Imperial College London
Department Name: National Heart and Lung Institute

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Hayward C (2014) Gene therapy in heart failure. SERCA2a as a therapeutic target. in Circulation journal : official journal of the Japanese Circulation Society

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Hayward C (2014) Gene therapy in heart failure. SERCA2a as a therapeutic target. in Circulation journal : official journal of the Japanese Circulation Society

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Jawad H (2008) Myocardial tissue engineering. in British medical bulletin

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Jin H (2008) Arrhythmia mechanisms in the failing heart. in Pacing and clinical electrophysiology : PACE

 
Description AMS, Clinical Lecturer Starter Grant
Amount £30,000 (GBP)
Organisation Academy of Medical Sciences (AMS) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2009 
End 12/2011
 
Description BHF Intermediate Clinical Research Fellowship
Amount £819,930 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2012 
End 12/2015
 
Description BHF Special Programme Award
Amount £315,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2010 
End 06/2016
 
Description Collaboration with Celladon
Amount £174,085 (GBP)
Organisation Celladon 
Sector Private
Country United States
Start 03/2013 
End 07/2015
 
Description HFA Nursing Fellowship
Amount £40,000 (GBP)
Organisation European Society of Cardiology (ESC) 
Sector Charity/Non Profit
Country France
Start 11/2014 
End 10/2015
 
Description Welcome Trust Clinical PhD Fellowship
Amount £515,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2010 
End 09/2013
 
Description Consultant to international phase 2b gene therapy trial 
Organisation Celladon
Country United States 
Sector Private 
PI Contribution International consultant to Celladon Advice re design and management of clinical gene therapy trial UK National Coordinating Investigator for the CUPID2 trial.
Collaborator Contribution Sponsor of trial
Impact Starting Phase 2b SERCA2a gene therapy trial in Heart failure patients in the UK
Start Year 2011
 
Description Gene therapy collaboration 
Organisation Mount Sinai Hospital (USA)
Country United States 
Sector Hospitals 
PI Contribution Novel studies of cardiomyocytes after cardiac gene transfer.
Collaborator Contribution Gift of state-of-the-art gene therapy vectors for cardiac gene transfer studies.
Impact Two papers currently under review One paper Published One manuscript in preparation
Start Year 2007
 
Description Investigation of ryanodine receptor stabiliser pharmacology 
Organisation Servier Laboratories
Country France 
Sector Private 
PI Contribution Assessment in in vivo heart failure models and in vitro cell studies
Collaborator Contribution Drug supply and financial support
Impact Full report Awaiting scientific publication
Start Year 2010
 
Description SERCA-LVAD trial 
Organisation Celladon
Country United States 
Sector Private 
PI Contribution PI for the SERCA-LVAD Gene Therapy Trial ClinicalTrials.gov Identifier: NCT00534703; EudraCT : 2007-002809-48
Collaborator Contribution Finanical Delivery and provision of 24 doses of SERCA2a gene therapy or placebo 24 month salary for research nurse
Impact European leading recruitment centre for CUPID2 trial
Start Year 2012
 
Title SERCA2a Gene Therapy 
Description SERCA2a gene therapy trial - completed recruitment, currently in active follow up phase 
Type Therapeutic Intervention - Cellular and gene therapies
Current Stage Of Development Late clinical evaluation
Year Development Stage Completed 2014
Development Status Under active development/distribution
Clinical Trial? Yes
Impact We are Europe's leading recruitment centre for the international CUPID2 trial, and I have been invited to lead the arrhythmia substudy. 
 
Title SERCA2a gene therapy 
Description Started recruitment of SERCA-LVAD Trial: Investigation of the safety and efficacy of AAV1/SERCA2a gene transfer in patients with chronic heart failure and a left ventricular assist device: The SERCA-LVAD trial (ClinicalTrials.gov Identifier: NCT00534703; EudraCT : 2007-002809-48). 
Type Therapeutic Intervention - Cellular and gene therapies
Current Stage Of Development Late clinical evaluation
Year Development Stage Completed 2007
Development Status Under active development/distribution
Clinical Trial? Yes
Impact World's first clinical trial of gene therapy in this patient group (adults with LVADs fro chronic heart failure) 
 
Description Cafe Scientifique 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Q+A from an audience of 70 members fo the public following a 5-10 minute oral presentation, chaired by professor Richard Ashcroft.

House of Lords interest and approached me to participate in an advisory panel; patient recruitment into the gene therapy trial; local students interested for their projects and work experience.
Year(s) Of Engagement Activity 2012
 
Description Channel 4 News piece 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Recorded news piece on cardiac gene therapy for the Channel 4 news

Public interest
Year(s) Of Engagement Activity 2013
URL http://www.channel4.com/news/gene-therapy-hope-for-heart-failure-patients
 
Description Imperial College Outreach Programme for Local Schools 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Schools
Results and Impact Hosted sixth form students from local schools to offer them an insight into medical research and medical careers.

I have been contacted by several of the participants for further advice regarding applications to medical school and/or university for biological sciences.
Year(s) Of Engagement Activity 2008,2009,2010,2011,2012
 
Description National Newspaper Coverage 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Front page of Daily Telegraph - coverage of our new gene therapy trial

Contact from media organisations and patients
Year(s) Of Engagement Activity 2014
URL http://www.telegraph.co.uk/health/healthnews/11027207/Pioneering-new-injection-to-cure-heart-failure...
 
Description News article for Sky News 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Recorded news piece on cardiac gene therapy for the Sky news

Public interest and feedback
Year(s) Of Engagement Activity 2013
URL http://news.sky.com/story/1084769/heart-failure-first-uk-gene-therapy-trial
 
Description Radio Interview for the Today programme 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Recorded interview for the Today programme regarding Gene therapy trial.

Public interest in the trial and BHF funding.
Year(s) Of Engagement Activity 2006,2013
 
Description Recorded interview for the BBC National news 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Recorded piece with Fergus Walsh for the National BBC six and ten o'clock news

Public interest and feedback
Year(s) Of Engagement Activity 2013
URL http://www.bbc.co.uk/news/health-23962607
 
Description Recorded radio interview for Today programme 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Recorded interview for the Today programme regarding the SERCA2a gene therapy trial

Public feedback and interest
Year(s) Of Engagement Activity 2013
 
Description Talk to Friends of the Royal Brompton Hospital 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Talk to ~30 members of the public who are part of the 'Friends of the Royal brompton Hospital' support group.

Positive feedback from the meeting chair.
Year(s) Of Engagement Activity 2013