Surgical Trial in Lobar Intracerebral Haemorrhage

Lead Research Organisation: Newcastle University
Department Name: Unlisted

Abstract

Stroke is the leading cause of disability in the UK and the third most common cause of death. Brain haemorrhage accounts for 20% of all strokes and is even more common as a cause of stroke in younger patients. Despite this, neurosurgeons do not know whether to operate or not in many of their patients. A previous study (STICH I) identified a promising subgroup of patients in whom surgery might be of benefit but a further larger study is required to prove it. The Surgical Trial in Lobar Intracerebral Haemorrhage (STICH II) is a study to investigate whether a policy of early operation to remove the clot following a brain haemorrhage gives a better outcome than a policy of wait-and-see. Six hundred patients from 40 centres around the world will be included in the study.

Patients admitted to hospital with a brain haemorrhage are assessed by the neurosurgeon. Some patients are known to need an operation if there is a large clot and their condition worsens. It is known that some patients do not need an operation because the clot is small. Between these extremes there is little evidence about which is the best treatment but there have been some recent experiments that have suggested that early removal of the clot may reduce brain damage. Further analysis of a recent large study has suggested that this may particularly be the case for haemorrhages close to the surface of the brain that do not require cutting through a large amount of healthy brain to reach the haemorrhage. This group of patients are asked if they are willing to take part in the study.

If a patient agrees he or she is allocated to either an early operation or to best medical treatment with a later operation if his or her condition becomes worse. All patients receive best medical treatment whichever group they are in. A questionnaire is sent to the patient six months later to be completed by the patient or carer. The questionnaire includes questions about the patient s ability to carry out activities in their daily life.

It is expected that this study will help to identify which patients will recover better from a brain haemorrhage if they have an early operation and which patients will recover better if they do not have an operation.

Technical Summary

Stroke is the leading cause of disability in the UK and the third commmonest cause of death. Intracerebral haemorrhage accounts for 20% of all strokes and is even more common as a cause of stroke in younger patients. Despite this, clinical uncertainty remains amongst neurosurgeons regarding whether to operate or not in many of their patients. STICH I suggested that patients with lobar haematomas only were more likely to benefit from surgical intervention but this subgroup analysis was not prespecified and can only be regarded as hypothesis generating. The Surgical Trial in Lobar Intracerebral Haemorrhage (STICH II) will be an international multicentre randomised parallel group trial to investigate whether a policy of early evacuation of the haematoma in selected patients with spontaneous supratentorial lobar intracerebral haemorrhage improves outcome compared to a policy of initial conservative treatment. Six hundred patients for whom the treating neurosurgeon is uncertain about the most beneficial treatment will be randomised using a 24 hour telephone randomisation service. Case report forms will be completed at randomisation and two-weeks later and returned to the STICH office in Newcastle. The success of the two policies in reducing the size of the haematoma will be assessed by comparison of prerandomisation and one week post randomisation CT scans. Outcome will be collected via a six-month postal questionnaire to the surviving patients or their carers to assess the level of disability using the Glasgow Outcome Scale and modified Rankin Score.

Organisations

Publications

10 25 50
 
Description Citation in Cochrane Review and authors of Cochrane Review
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in systematic reviews
Impact Clarify indications for surgery with ICH
 
Description HTA Trial 07/37/16 Surgical Trial In Traumatic intraCerebral Haemorrhage [STITCH)
Amount £2,300,000 (GBP)
Funding ID HTA/07/37/16 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 09/2009 
End 02/2014
 
Description STICH II Investigating sites 
Organisation AMRI Hospitals
Department Department of Neurosurgery
Country India 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Aberdeen Royal Infirmary
Department Department of Neurosurgery
Country United Kingdom 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Addenbrooke's Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Albany Medical College
Department Neurosciences Institute AMC
Country United States 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Alexandria University Hospitals
Department Department of Neurosurgery
Country Egypt 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation All India Institute of Medical Sciences
Department Department of Neurosurgery
Country India 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Aristotle University of Thessaloniki
Department Department of Neurosurgery
Country Greece 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Asklepios Clinic Altona
Department Department of Neurosurgery
Country Germany 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation B.P. Koirala Institute of Health Sciences
Country Nepal 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Baidya and Banskota Hospital (BBH)
Department Department of Neurosurgery
Country Nepal 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Borsod County and University Teaching Hospital
Department Department of Neurosurgery
Country Hungary 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Brighton and Sussex University Hospitals NHS Trust
Department Neuroscience & Ophthamology Brighton
Country United Kingdom 
Sector Public 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Capital University of Medical Sciences
Department Department of Neurosurgery
Country China 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Central Illinois Neuroscience Foundation (CINF)
Country United States 
Sector Charity/Non Profit 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Central Military Hospital
Department Neurosurgical Department
Country Czech Republic 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Charité - University of Medicine Berlin
Department Center for Stroke Research Berlin
Country Germany 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Christian Medical College Ludhiana Society
Department Christian Medical College and Hospital Ludhiana
Country India 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation County Emergency Hospital of Timisoara (SCJUT)
Country Romania 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation County Emergency Hospital, Cluj-Napoca
Country Romania 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Cruces Hospital, Bilbao
Department Department of Neurosurgery
Country Spain 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Espases University Hospital
Department Department of Neurosurgery
Country Spain 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Evangelismos Hospital
Department Department of Neurosurgery
Country Greece 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (TCM)
Department Department of Neurosurgery
Country China 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Fudan University
Department Huashan Hospital
Country China 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Georgia Neurosurgical Institute
Country United States 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Germans Trias i Pujol University Hospital
Department Department of Neurosurgery
Country Spain 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Global Hospitals Group
Department Advanced Neurosciences Institute
Country United States 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Hartford Hospital
Department Department of Neurosurgery
Country United States 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Heidelberg University Hospital
Department Department of Neurosurgery
Country Germany 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Heinrich Heine University Düsseldorf
Department Neurosurgery Clinic Heinrich Heine
Country Germany 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Helios Hospital Berlin-Buch
Department Department of Neurosurgery
Country Germany 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Hippokration General Hospital
Department Department of Neurosurgery
Country Greece 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Hirosaki University
Department Department of Neurosurgery
Country Japan 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Horst Schmidt Kliniken, Wiesbaden
Department Department of Neurosurgery
Country Germany 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Hospital Civil de Guadalajara (HCG)
Country Mexico 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Hospital Sultanah Aminah, Johor Bahru
Department Department of Neurosurgery
Country Malaysia 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Hull Royal Infirmary
Department Department of Neurosurgery
Country United Kingdom 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Istanbul University
Department Department of Neurology
Country Turkey 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation James Cook University Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Jung Stilling Hospital
Department Department of Neurosurgery
Country Germany 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Kamineni Life Sciences
Country India 
Sector Private 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Kassel Hospital
Department Neurosurgery Clinic Klinikum Kassel
Country Germany 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Kassel Hospital
Department Neurosurgery Clinic Klinikum Kassel
Country Germany 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Kerala Institute of Medical Sciences (KIMS)
Department Department of Neurosurgery
Country India 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation King Khalid University Hospital, Riyadh
Department Neurosurgery Division King Khalid
Country Saudi Arabia 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Lahore General Hospital
Country Pakistan 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Leeds Teaching Hospitals NHS Trust
Department Department of Neurosurgery
Country United Kingdom 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Liberec Regional Hospital
Department Department of Neurosurgery
Country Czech Republic 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Loyola University Medical Center
Country United States 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Maharishi Markandeshwar University
Department Department of Neurosurgery
Country India 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Mansoura University
Department Department of Neurosurgery
Country Egypt 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Mayo Clinic
Country United States 
Sector Charity/Non Profit 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Medical University of Vienna
Department Department of Neurosurgery
Country Austria 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Municipal Hospital Dessau
Department Department of Neurosurgery
Country Germany 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation NTT Medical Center Tokyo
Department Department of Neurosurgery
Country Japan 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation National Hospital for Neurology and Neurosurgery
Country United Kingdom 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation National Hospital of Sri Lanka
Department Department of Neurosurgery
Country Sri Lanka 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation National Institute of Mental Health and Neurosciences
Department Department of Neurosurgery
Country India 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation National Medical Centre (Seoul)
Department Department of Neurosurgery
Country Korea, Republic of 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation National Neurosciences Centre, Calcutta
Department Department of Neurosurgery
Country India 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation National Scientific Practical Centre of Emergency Medicine, Chisinau
Department Neurosurgery Clinic
Country Moldova, Republic of 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation National University Hospital (NUH)
Department Division of Neurosurgery
Country Singapore 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Neurosurgery Clinic Greifswald
Country Germany 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Ninewells Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Northwest General Hospital & Research Centre, Peshawar
Country Pakistan 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Olomouc Teaching Hospital
Department Department of Neurosurgery
Country Czech Republic 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Oxford University Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Pauls Stradins Clinical University Hospital
Department Neurosurgery Clinic Pauls Stradins
Country Latvia 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Penn State Milton S. Hershey Medical Center
Department Penn State Hershey Neurosurgery
Country United States 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Poznan University of Medical Sciences
Department Clinic and Department of Neurosurgery and Neurotraumatology
Country Poland 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Rambam Government Hospital
Department Department of Neurosurgery
Country Israel 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Republic Klaipeda Hospital
Department Department of Neurosurgery
Country Lithuania 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Research Medical Center, Kansas
Country United States 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Riga East Clinical University Hospital
Department Department of Neurosurgery
Country Latvia 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Royal Preston Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Rudolfstiftung Hospital
Department Department of Neurosurgery
Country Austria 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Salford Royal NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Sapienza University of Rome
Department Department of Neurological Sciences
Country Italy 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Sheba Medical Centre
Department Department of Neurosurgery
Country Israel 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST)
Department Department of Neurosurgery
Country India 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation St Anne's University Hospital
Department Department of Neurosurgery
Country Czech Republic 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation St Anne's University Hospital
Department Department of Neurosurgery
Country Czech Republic 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation St George's University of London
Department Academic Neurosurgery Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation St Joseph's/Candler Health System
Department Institute for Neurosciences
Country United States 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation St Jude Children's Hospital
Department Department of Surgery
Country United States 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation St. Marien Amberg Hospital
Department Neurosurgery Department
Country Germany 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Steve Biko Academic Hospital
Department Department of Neurosurgery
Country South Africa 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Taipei Medical University Hospital
Department Department of Neurosurgery
Country Taiwan, Province of China 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Tbilisi State Medical University
Department Department of Neurosurgery
Country Georgia 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Temple University
Department Department of Neurosurgery
Country United States 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation The Otto-von-Guericke University Magdeburg
Department Department of Neurology
Country Germany 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation The Railway Hospital, Novosibirsk
Country Russian Federation 
Sector Multiple 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation The Walton Centre
Department Department of Neurosurgery
Country United Kingdom 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Trondheim University Hospital
Department Department of Neurosurgery
Country Norway 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation University College London Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation University Hospital Erlangen
Department Department of Neurosurgery
Country Germany 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation University Hospital Jena
Department Clinic for Neurosurgery
Country Germany 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation University Hospital Murcia
Department Department of Neurosurgery
Country Spain 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation University Hospital Ostrava
Department Department of Neurosurgery
Country Czech Republic 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation University Hospital Saarland (UKS)
Department Clinic for Neurosurgery
Country Germany 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation University Hospital Schleswig-Holstein
Department Clinic of Neurosurgery
Country Germany 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation University Hospital Southampton NHS Foundation Trust
Department Wessex Neurological Centre
Country United Kingdom 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation University Hospital Virgen de las Nieves, Granada
Country Spain 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation University Hospital of North Staffordshire NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation University Hospital of Valladolid
Department Department of Neurosurgery
Country Spain 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation University Hospital of Valladolid
Country Spain 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation University Medical Center Gronigen
Country Netherlands 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation University of Bialystok
Department Medical School Bialystok
Country Poland 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation University of Cantabria
Department Marqués de Valdecilla University Hospital
Country Spain 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation University of Illinois at Chicago
Department Department of Neurosurgery
Country United States 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation University of Louisville
Department Department of Neurosurgery
Country United States 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation University of Melbourne
Country Australia 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation University of Münster
Department Clemenshospital, Teaching Hospital
Country Germany 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation University of Münster
Country Germany 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation University of Science Malaysia
Department Department of Neurosciences
Country Malaysia 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation University of Virginia (UVa)
Department Department of Neurosurgery
Country United States 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Uppsala University Hospital
Department Department of Neurosurgery
Country Sweden 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Washington University in St Louis
Department Department of Neurosurgery
Country United States 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Western General Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Yerevan State Medical University, Armenia
Country Armenia 
Sector Academic/University 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description STICH II Investigating sites 
Organisation Zagazig University Hospitals
Country Egypt 
Sector Hospitals 
PI Contribution Manage the study
Collaborator Contribution Recruit patients
Impact Recruitment of patients
Start Year 2006
 
Description Presentations 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Health professionals
Results and Impact Presentations to sites involved in the study made at hospitals in UK, across Europe, USA, Asia.

Raised awareness, improved collaboration, improved recruitment of patients.
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010