Surgical Trial in Lobar Intracerebral Haemorrhage
Lead Research Organisation:
Newcastle University
Department Name: Unlisted
Abstract
Stroke is the leading cause of disability in the UK and the third most common cause of death. Brain haemorrhage accounts for 20% of all strokes and is even more common as a cause of stroke in younger patients. Despite this, neurosurgeons do not know whether to operate or not in many of their patients. A previous study (STICH I) identified a promising subgroup of patients in whom surgery might be of benefit but a further larger study is required to prove it. The Surgical Trial in Lobar Intracerebral Haemorrhage (STICH II) is a study to investigate whether a policy of early operation to remove the clot following a brain haemorrhage gives a better outcome than a policy of wait-and-see. Six hundred patients from 40 centres around the world will be included in the study.
Patients admitted to hospital with a brain haemorrhage are assessed by the neurosurgeon. Some patients are known to need an operation if there is a large clot and their condition worsens. It is known that some patients do not need an operation because the clot is small. Between these extremes there is little evidence about which is the best treatment but there have been some recent experiments that have suggested that early removal of the clot may reduce brain damage. Further analysis of a recent large study has suggested that this may particularly be the case for haemorrhages close to the surface of the brain that do not require cutting through a large amount of healthy brain to reach the haemorrhage. This group of patients are asked if they are willing to take part in the study.
If a patient agrees he or she is allocated to either an early operation or to best medical treatment with a later operation if his or her condition becomes worse. All patients receive best medical treatment whichever group they are in. A questionnaire is sent to the patient six months later to be completed by the patient or carer. The questionnaire includes questions about the patient s ability to carry out activities in their daily life.
It is expected that this study will help to identify which patients will recover better from a brain haemorrhage if they have an early operation and which patients will recover better if they do not have an operation.
Patients admitted to hospital with a brain haemorrhage are assessed by the neurosurgeon. Some patients are known to need an operation if there is a large clot and their condition worsens. It is known that some patients do not need an operation because the clot is small. Between these extremes there is little evidence about which is the best treatment but there have been some recent experiments that have suggested that early removal of the clot may reduce brain damage. Further analysis of a recent large study has suggested that this may particularly be the case for haemorrhages close to the surface of the brain that do not require cutting through a large amount of healthy brain to reach the haemorrhage. This group of patients are asked if they are willing to take part in the study.
If a patient agrees he or she is allocated to either an early operation or to best medical treatment with a later operation if his or her condition becomes worse. All patients receive best medical treatment whichever group they are in. A questionnaire is sent to the patient six months later to be completed by the patient or carer. The questionnaire includes questions about the patient s ability to carry out activities in their daily life.
It is expected that this study will help to identify which patients will recover better from a brain haemorrhage if they have an early operation and which patients will recover better if they do not have an operation.
Technical Summary
Stroke is the leading cause of disability in the UK and the third commmonest cause of death. Intracerebral haemorrhage accounts for 20% of all strokes and is even more common as a cause of stroke in younger patients. Despite this, clinical uncertainty remains amongst neurosurgeons regarding whether to operate or not in many of their patients. STICH I suggested that patients with lobar haematomas only were more likely to benefit from surgical intervention but this subgroup analysis was not prespecified and can only be regarded as hypothesis generating. The Surgical Trial in Lobar Intracerebral Haemorrhage (STICH II) will be an international multicentre randomised parallel group trial to investigate whether a policy of early evacuation of the haematoma in selected patients with spontaneous supratentorial lobar intracerebral haemorrhage improves outcome compared to a policy of initial conservative treatment. Six hundred patients for whom the treating neurosurgeon is uncertain about the most beneficial treatment will be randomised using a 24 hour telephone randomisation service. Case report forms will be completed at randomisation and two-weeks later and returned to the STICH office in Newcastle. The success of the two policies in reducing the size of the haematoma will be assessed by comparison of prerandomisation and one week post randomisation CT scans. Outcome will be collected via a six-month postal questionnaire to the surviving patients or their carers to assess the level of disability using the Glasgow Outcome Scale and modified Rankin Score.
Organisations
- Newcastle University, United Kingdom (Lead Research Organisation)
- University Hospital Son Espases (Collaboration)
- South Tees Hospitals NHS Foundtn Trust (Collaboration)
- Temple University (Collaboration)
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (TCM) (Collaboration)
- Mayo Clinic (Collaboration)
- Kassel Hospital (Collaboration)
- Maharishi Markandeshwar University (Collaboration)
- Hospital Civil de Guadalajara (HCG) (Collaboration)
- Northwest General Hospital & Research Centre, Peshawar (Collaboration)
- Zagazig University Hospitals (Collaboration)
- National University Hospital (NUH) (Collaboration)
- National Medical Centre (Seoul) (Collaboration)
- Uppsala University Hospital (Collaboration)
- Global Hospitals Group (Collaboration)
- Tibilisi State Medical University (Collaboration)
- University of Rome I (La Sapienza), Italy (Collaboration)
- Hartford Hospital (Collaboration)
- University Hospital Schleswig-Holstein (Collaboration)
- Research Medical Center, Kansas (Collaboration)
- County Emergency Hospital of Timisoara (SCJUT) (Collaboration)
- Lahore General Hospital (Collaboration)
- Aberdeen Royal Infirmary, United Kingdom (Collaboration)
- Central Military Hospital (Collaboration)
- University of Muenster (Munster), Germany (Collaboration)
- University of Louisville (Collaboration)
- Penn State Milton S. Hershey Medical Center (Collaboration)
- Hospital Sultanah Aminah, Johor Bahru (Collaboration)
- Kamineni Life Sciences (Collaboration)
- Washington University in St Louis, United States (Collaboration)
- Fudan University (Collaboration)
- AMRI Hospitals (Collaboration)
- Trondheim University Hospital (Collaboration)
- Rudolfstiftung Hospital (Collaboration)
- University Hospital of Erlangen (Collaboration)
- Cruces Hospital, Bilbao (Collaboration)
- Addenbrooke's Hospital (Collaboration)
- University Hospital Jena (Collaboration)
- Steve Biko Academic Hospital (Collaboration)
- Horst Schmidt Kliniken, Wiesbaden (Collaboration)
- NTT Medical Center Tokyo (Collaboration)
- Kerala Institute of Medical Sciences (KIMS) (Collaboration)
- The Railway Hospital, Novosibirsk (Collaboration)
- Germans University Hospital (Collaboration)
- Republic Klaipeda Hospital (Collaboration)
- Municipal Hospital Dessau (Collaboration)
- Albany Medical College (Collaboration)
- King Khalid University Hospital (KKUH) (Collaboration)
- Sheba Medical Centre (Collaboration)
- University Hospital Ostrava (Collaboration)
- Otto-von-Guericke University Magdeburg, Germany (Collaboration)
- Royal Preston Hospital (Collaboration)
- Jung Stilling Hospital (Collaboration)
- Rambam Government Hospital (Collaboration)
- Ninewells Hospital (Collaboration)
- Riga East Clinical University Hospital (Collaboration)
- County Emergency Hospital, Cluj-Napoca (Collaboration)
- Brighton and Sussex University Hospitals NHS Trust (Collaboration)
- Alexandria University Hospital (Collaboration)
- University of Illinois at Chicago, United States (Collaboration)
- Charité - University of Medicine Berlin (Collaboration)
- Baidya and Banskota Hospital (BBH) (Collaboration)
- Central Illinois Neuroscience Foundation (CINF) (Collaboration)
- St Joseph's/Candler Health System (Collaboration)
- University Hospital Murcia (Collaboration)
- Borsod County University Teaching Hospital (Collaboration)
- National Hospital of Sri Lanka (Collaboration)
- B.P. Koirala Institute of Health Sciences (Collaboration)
- Hull Royal Infirmary, United Kingdom (Collaboration)
- Mansoura University (Collaboration)
- St Jude Children's Hospital (Collaboration)
- University Hospital of North Staffordshire NHS Trust (Collaboration)
- Georgia Neurosurgical Institute (Collaboration)
- University of Melbourne, Australia (Collaboration)
- Hippokration General Hospital (Collaboration)
- University of Virginia, United States (Collaboration)
- Asklepios Clinic Altona (Collaboration)
- Loyola University Medical Center (Collaboration)
- St Anne's University Hospital (Collaboration)
- University Hospital Southampton NHS Foundation Trust, Southampton (Collaboration)
- Istanbul University (Collaboration)
- Western General Hospital (Collaboration)
- University Hospital Virgen de las Nieves, Granada (Collaboration)
- University of Science Malaysia (Collaboration)
- University of Cantabria, Spain (Collaboration)
- National Institute of Mental Health and Neurosciences (Collaboration)
- National Neurosciences Centre, Calcutta (Collaboration)
- Leeds Teaching Hospitals NHS Trust, Leeds (Collaboration)
- Christian Medical College Ludhiana Society (Collaboration)
- Liberec Regional Hospital (Collaboration)
- University Hospital Saarland (UKS) (Collaboration)
- St. Marien Amberg Hospital (Collaboration)
- Heidelberg University Hospital (Collaboration)
- University of Bialystok (Collaboration)
- Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST) (Collaboration)
- Heinrich Heine University Düsseldorf (Collaboration)
- Olomouc Teaching Hospital (Collaboration)
- The Walton Centre (Collaboration)
- National Scientific Practical Centre of Emergency Medicine, Chisinau (Collaboration)
- Neurosurgery Clinic Greifswald (Collaboration)
- National Hospital for Neurology and Neurosurgery (Collaboration)
- St George's University of London, United Kingdom (Collaboration)
- Aristotle University of Thessaloniki (Collaboration)
- Pauls Stradins Clinical University Hospital (Collaboration)
- Salford Royal NHS Foundation Trust, Greater Manchester (Collaboration)
- University College London Hospital (UCLH) NHS Foundation Trust (Collaboration)
- Hirosaki University (Collaboration)
- University Hospital of Valladolid (Collaboration)
- All India Institute of Medical Sciences (Collaboration)
- Medical University of Vienna (Collaboration)
- Taipei Medical University Hospital (Collaboration)
- Yerevan State Medical University, Armenia (Collaboration)
- University Medical Center Gronigen (Collaboration)
- Poznan University of Medical Sciences (Collaboration)
- Helios Hospital Berlin-Buch (Collaboration)
- Evangelismos Hospital (Collaboration)
- Capital Medical University (Collaboration)
- Oxford University Hospitals NHS Foundation Trust (Collaboration)
Publications

Ali M
(2007)
The Virtual International Stroke Trials Archive.
in Stroke

Bhattathiri P
(2006)
Brain Edema XIII

Chambers IR
(2008)
The measurement of brain tissue stiffness in-vivo.
in Acta neurochirurgica. Supplement

Gregson BA
(2012)
Update on the Surgical Trial in Lobar Intracerebral Haemorrhage (STICH II): statistical analysis plan.
in Trials




Kenyon GM
(2011)
Obtaining regulatory approval for multicentre randomised controlled trials: experiences in the STICH II trial.
in British journal of neurosurgery

Kirkman MA
(2008)
The effect of the results of the STICH trial on the management of spontaneous supratentorial intracerebral haemorrhage in Newcastle.
in British journal of neurosurgery

Kirkman MA
(2009)
The accuracy of hospital discharge coding for hemorrhagic stroke.
in Acta neurologica Belgica
Description | Citation in Cochrane Review and authors of Cochrane Review |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Citation in systematic reviews |
Impact | Clarify indications for surgery with ICH |
Description | HTA Trial 07/37/16 Surgical Trial In Traumatic intraCerebral Haemorrhage [STITCH) |
Amount | £2,300,000 (GBP) |
Funding ID | HTA/07/37/16 |
Organisation | National Institute for Health Research |
Department | Health Technology Assessment Programme (HTA) |
Sector | Public |
Country | United Kingdom |
Start | 08/2009 |
End | 02/2014 |
Description | STICH II Investigating sites |
Organisation | AMRI Hospitals |
Department | Department of Neurosurgery |
Country | India |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Aberdeen Royal Infirmary |
Department | Department of Neurosurgery |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Addenbrooke's Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Albany Medical College |
Department | Neurosciences Institute AMC |
Country | United States |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Alexandria University Hospitals |
Department | Department of Neurosurgery |
Country | Egypt |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | All India Institute of Medical Sciences |
Department | Department of Neurosurgery |
Country | India |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Aristotle University of Thessaloniki |
Department | Department of Neurosurgery |
Country | Greece |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Asklepios Clinic Altona |
Department | Department of Neurosurgery |
Country | Germany |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | B.P. Koirala Institute of Health Sciences |
Country | Nepal |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Baidya and Banskota Hospital (BBH) |
Department | Department of Neurosurgery |
Country | Nepal |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Borsod County and University Teaching Hospital |
Department | Department of Neurosurgery |
Country | Hungary |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Brighton and Sussex University Hospitals NHS Trust |
Department | Neuroscience & Ophthamology Brighton |
Country | United Kingdom |
Sector | Public |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Capital University of Medical Sciences |
Department | Department of Neurosurgery |
Country | China |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Central Illinois Neuroscience Foundation (CINF) |
Country | United States |
Sector | Charity/Non Profit |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Central Military Hospital |
Department | Neurosurgical Department |
Country | Czech Republic |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Charité - University of Medicine Berlin |
Department | Center for Stroke Research Berlin |
Country | Germany |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Christian Medical College Ludhiana Society |
Department | Christian Medical College and Hospital Ludhiana |
Country | India |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | County Emergency Hospital of Timisoara (SCJUT) |
Country | Romania |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | County Emergency Hospital, Cluj-Napoca |
Country | Romania |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Cruces Hospital, Bilbao |
Department | Department of Neurosurgery |
Country | Spain |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Espases University Hospital |
Department | Department of Neurosurgery |
Country | Spain |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Evangelismos Hospital |
Department | Department of Neurosurgery |
Country | Greece |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (TCM) |
Department | Department of Neurosurgery |
Country | China |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Fudan University |
Department | Huashan Hospital |
Country | China |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Georgia Neurosurgical Institute |
Country | United States |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Germans Trias i Pujol University Hospital |
Department | Department of Neurosurgery |
Country | Spain |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Global Hospitals Group |
Department | Advanced Neurosciences Institute |
Country | United States |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Hartford Hospital |
Department | Department of Neurosurgery |
Country | United States |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Heidelberg University Hospital |
Department | Department of Neurosurgery |
Country | Germany |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Heinrich Heine University Düsseldorf |
Department | Neurosurgery Clinic Heinrich Heine |
Country | Germany |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Helios Hospital Berlin-Buch |
Department | Department of Neurosurgery |
Country | Germany |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Hippokration General Hospital |
Department | Department of Neurosurgery |
Country | Greece |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Hirosaki University |
Department | Department of Neurosurgery |
Country | Japan |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Horst Schmidt Kliniken, Wiesbaden |
Department | Department of Neurosurgery |
Country | Germany |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Hospital Civil de Guadalajara (HCG) |
Country | Mexico |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Hospital Sultanah Aminah, Johor Bahru |
Department | Department of Neurosurgery |
Country | Malaysia |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Hull Royal Infirmary |
Department | Department of Neurosurgery |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Istanbul University |
Department | Department of Neurology |
Country | Turkey |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | James Cook University Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Jung Stilling Hospital |
Department | Department of Neurosurgery |
Country | Germany |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Kamineni Life Sciences |
Country | India |
Sector | Private |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Kassel Hospital |
Department | Neurosurgery Clinic Klinikum Kassel |
Country | Germany |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Kassel Hospital |
Department | Neurosurgery Clinic Klinikum Kassel |
Country | Germany |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Kerala Institute of Medical Sciences (KIMS) |
Department | Department of Neurosurgery |
Country | India |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | King Khalid University Hospital, Riyadh |
Department | Neurosurgery Division King Khalid |
Country | Saudi Arabia |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Lahore General Hospital |
Country | Pakistan |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Leeds Teaching Hospitals NHS Trust |
Department | Department of Neurosurgery |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Liberec Regional Hospital |
Department | Department of Neurosurgery |
Country | Czech Republic |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Loyola University Medical Center |
Country | United States |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Maharishi Markandeshwar University |
Department | Department of Neurosurgery |
Country | India |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Mansoura University |
Department | Department of Neurosurgery |
Country | Egypt |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Mayo Clinic |
Country | United States |
Sector | Charity/Non Profit |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Medical University of Vienna |
Department | Department of Neurosurgery |
Country | Austria |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Municipal Hospital Dessau |
Department | Department of Neurosurgery |
Country | Germany |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | NTT Medical Center Tokyo |
Department | Department of Neurosurgery |
Country | Japan |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | National Hospital for Neurology and Neurosurgery |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | National Hospital of Sri Lanka |
Department | Department of Neurosurgery |
Country | Sri Lanka |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | National Institute of Mental Health and Neurosciences |
Department | Department of Neurosurgery |
Country | India |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | National Medical Centre (Seoul) |
Department | Department of Neurosurgery |
Country | Korea, Republic of |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | National Neurosciences Centre, Calcutta |
Department | Department of Neurosurgery |
Country | India |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | National Scientific Practical Centre of Emergency Medicine, Chisinau |
Department | Neurosurgery Clinic |
Country | Moldova, Republic of |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | National University Hospital (NUH) |
Department | Division of Neurosurgery |
Country | Singapore |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Neurosurgery Clinic Greifswald |
Country | Germany |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Ninewells Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Northwest General Hospital & Research Centre, Peshawar |
Country | Pakistan |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Olomouc Teaching Hospital |
Department | Department of Neurosurgery |
Country | Czech Republic |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Oxford University Hospitals NHS Foundation Trust |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Pauls Stradins Clinical University Hospital |
Department | Neurosurgery Clinic Pauls Stradins |
Country | Latvia |
Sector | Public |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Penn State Milton S. Hershey Medical Center |
Department | Penn State Hershey Neurosurgery |
Country | United States |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Poznan University of Medical Sciences |
Department | Clinic and Department of Neurosurgery and Neurotraumatology |
Country | Poland |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Rambam Government Hospital |
Department | Department of Neurosurgery |
Country | Israel |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Republic Klaipeda Hospital |
Department | Department of Neurosurgery |
Country | Lithuania |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Research Medical Center, Kansas |
Country | United States |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Riga East Clinical University Hospital |
Department | Department of Neurosurgery |
Country | Latvia |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Royal Preston Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Rudolfstiftung Hospital |
Department | Department of Neurosurgery |
Country | Austria |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Salford Royal NHS Foundation Trust |
Country | United Kingdom |
Sector | Public |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Sapienza University of Rome |
Department | Department of Neurological Sciences |
Country | Italy |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Sheba Medical Centre |
Department | Department of Neurosurgery |
Country | Israel |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST) |
Department | Department of Neurosurgery |
Country | India |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | St Anne's University Hospital |
Department | Department of Neurosurgery |
Country | Czech Republic |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | St Anne's University Hospital |
Department | Department of Neurosurgery |
Country | Czech Republic |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | St George's University of London |
Department | Academic Neurosurgery Unit |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | St Joseph's/Candler Health System |
Department | Institute for Neurosciences |
Country | United States |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | St Jude Children's Hospital |
Department | Department of Surgery |
Country | United States |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | St. Marien Amberg Hospital |
Department | Neurosurgery Department |
Country | Germany |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Steve Biko Academic Hospital |
Department | Department of Neurosurgery |
Country | South Africa |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Taipei Medical University Hospital |
Department | Department of Neurosurgery |
Country | Taiwan, Province of China |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Tbilisi State Medical University |
Department | Department of Neurosurgery |
Country | Georgia |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Temple University |
Department | Department of Neurosurgery |
Country | United States |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | The Otto-von-Guericke University Magdeburg |
Department | Department of Neurology |
Country | Germany |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | The Railway Hospital, Novosibirsk |
Country | Russian Federation |
Sector | Public |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | The Walton Centre |
Department | Department of Neurosurgery |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Trondheim University Hospital |
Department | Department of Neurosurgery |
Country | Norway |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | University College London Hospitals NHS Foundation Trust |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | University Hospital Erlangen |
Department | Department of Neurosurgery |
Country | Germany |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | University Hospital Jena |
Department | Clinic for Neurosurgery |
Country | Germany |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | University Hospital Murcia |
Department | Department of Neurosurgery |
Country | Spain |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | University Hospital Ostrava |
Department | Department of Neurosurgery |
Country | Czech Republic |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | University Hospital Saarland (UKS) |
Department | Clinic for Neurosurgery |
Country | Germany |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | University Hospital Schleswig-Holstein |
Department | Clinic of Neurosurgery |
Country | Germany |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | University Hospital Southampton NHS Foundation Trust |
Department | Wessex Neurological Centre |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | University Hospital Virgen de las Nieves, Granada |
Country | Spain |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | University Hospital of North Staffordshire NHS Trust |
Country | United Kingdom |
Sector | Public |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | University Hospital of Valladolid |
Department | Department of Neurosurgery |
Country | Spain |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | University Hospital of Valladolid |
Country | Spain |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | University Medical Center Gronigen |
Country | Netherlands |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | University of Bialystok |
Department | Medical School Bialystok |
Country | Poland |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | University of Cantabria |
Department | Marqués de Valdecilla University Hospital |
Country | Spain |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | University of Illinois at Chicago |
Department | Department of Neurosurgery |
Country | United States |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | University of Louisville |
Department | Department of Neurosurgery |
Country | United States |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | University of Melbourne |
Country | Australia |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | University of Münster |
Department | Clemenshospital, Teaching Hospital |
Country | Germany |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | University of Münster |
Country | Germany |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | University of Science Malaysia |
Department | Department of Neurosciences |
Country | Malaysia |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | University of Virginia (UVa) |
Department | Department of Neurosurgery |
Country | United States |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Uppsala University Hospital |
Department | Department of Neurosurgery |
Country | Sweden |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Washington University in St Louis |
Department | Department of Neurosurgery |
Country | United States |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Western General Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Yerevan State Medical University, Armenia |
Country | Armenia |
Sector | Academic/University |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | STICH II Investigating sites |
Organisation | Zagazig University Hospitals |
Country | Egypt |
Sector | Hospitals |
PI Contribution | Manage the study |
Collaborator Contribution | Recruit patients |
Impact | Recruitment of patients |
Start Year | 2006 |
Description | Presentations |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Type Of Presentation | Paper Presentation |
Geographic Reach | International |
Primary Audience | Health professionals |
Results and Impact | Presentations to sites involved in the study made at hospitals in UK, across Europe, USA, Asia. Raised awareness, improved collaboration, improved recruitment of patients. |
Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010,2011,2012 |