Design of a control system for stimulation of rats' whiskers during functional magnetic resonance imaging (fMRI)

Lead Research Organisation: King's College London
Department Name: Clinical Neuroscience

Abstract

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Publications

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Albieri G (2015) Rapid Bidirectional Reorganization of Cortical Microcircuits. in Cerebral cortex (New York, N.Y. : 1991)

 
Title whisker actuator 
Description We designed a device that works in high field strength imaging magnets that could deflect rodent whiskers and evoke a brain response that could be measured with fMRI 
Type Of Material Technology assay or reagent 
Year Produced 2007 
Provided To Others? Yes  
Impact We have used the tool to image experience-dependent plasticity in rat brains. fMRI has been extremely popular in human studies. However, it has proven difficult to image plasticity in animal models, which are the major source of our understanding of the cellular mechanisms of learning and memory. I believe we are the first group to image neocortical plasticity in an animal model 
 
Description whisker fMRI biomedical engineering 
Organisation Imperial College London
Department Department of Mechanical Engineering
Country United Kingdom 
Sector Academic/University 
PI Contribution My colloborators designed the whisker actuator. We used the device to imaging plasticity of the rodent whisker cortical map
Collaborator Contribution My collaborator was a central part of the design and build team that constructed a whisker actuator that could be used to deflect rodents' whiskers in a high-field (9.4T) magnet used for fMRI.My collaborator helped to design and build the whisker actuator that we used to image plasticity of rodent whisker cortical maps
Impact PMID: 17951597 Second paper submitted currently. Multidisciplinary team: fMRI, engineering
 
Description whisker fMRI biomedical engineering 
Organisation King's College London
Department Faculty of Natural & Mathematical Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution My colloborators designed the whisker actuator. We used the device to imaging plasticity of the rodent whisker cortical map
Collaborator Contribution My collaborator was a central part of the design and build team that constructed a whisker actuator that could be used to deflect rodents' whiskers in a high-field (9.4T) magnet used for fMRI.My collaborator helped to design and build the whisker actuator that we used to image plasticity of rodent whisker cortical maps
Impact PMID: 17951597 Second paper submitted currently. Multidisciplinary team: fMRI, engineering
 
Description Internet 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact The work has been put on my lab website. This forms part of an effort that I am leading to increase the interaction of the MRC Centre for Neurodegeneration Research with the public.

The work has been uploaded recently. I am not aware of an increase in funding in the field of research that I am working in, but I intend to apply for more funding soon.
Year(s) Of Engagement Activity 2007