Bridging the physical and life sciences-cementing the alliance of Loughborough University and the UHL NHS Trust
Lead Research Organisation:
Loughborough University
Department Name: Sch of Mechanical and Manufacturing Eng
Abstract
This award would enable the already close relationship that has been built up between the University and the UHL NHS Trust to be further cemented by its focus on working together by the exchange of staff. It will generate cutting edge interdisciplinary research activity within specified thematic areas for the mutual benefit of both organisations.
Technical Summary
This application will further build upon and enhance the existing relationships between Loughborough University and the University Hospitals of Leicester (UHL) NHS Trust. It will build a virtual faculty linking the scale and depth of the university culture of customer driven applied science, engineering and industrial partnership with the needs and research culture of the UHL NHS Trust, one of the largest outside London. It will create a lasting peer to peer basis for user driven interdisciplinary research between the two Institutions. The inititaive will deliver a step change in the understanding and experience of Loughborough University in the requirements of the clinical world, and an enhanced understanding by clinicians of the capabilities of current and emerging technologies.
Organisations
- Loughborough University, United Kingdom (Lead Research Organisation)
- Hygienics Biosecurity Ltd (Collaboration)
- Laboratory of the Government Chemist (LGC) Ltd (Collaboration)
- De Montfort University, United Kingdom (Collaboration)
- University of Sydney, Australia (Collaboration)
- Royal Free Hospital (Collaboration)
- Glenfield Hospital (Collaboration)
- University Hospitals of Leicester NHS Trust, Leicester (Collaboration)
- Macmillan Cancer Support, United Kingdom (Collaboration)
- Stanford University, United States (Collaboration)
- University of Wisconsin Madison, United States (Collaboration)
- Leeds Teaching Hospitals NHS Trust, United Kingdom (Collaboration)
- Beating Eating Disorders (beat) (Collaboration)
- St Thomas' Hospital (Collaboration)
- University of Indonesia, Indonesia (Collaboration)
- 3 M United Kingdom Plc, United Kingdom (Collaboration)
- East Midlands Medilink (Collaboration)
- Oxford University Hospitals NHS Trust, United Kingdom (Collaboration)
- University of Cambridge, United Kingdom (Collaboration)
- Royal Derby Hospital (Collaboration)
- UNLISTED (Collaboration)
- Leicestershire Partnership NHS Trust, United Kingdom (Collaboration)
- Leicester Royal Infirmary (Collaboration)
- Hope Against Cancer (Rutland and Leicestershire) (Collaboration)
- University of Pittsburgh (Collaboration)
- University of Leicester, United Kingdom (Collaboration)
People |
ORCID iD |
| David John Williams (Principal Investigator) |
Publications
Zheng J
(2008)
Effect of postural changes on lower limb blood volume, detected with non-invasive photoplethysmography.
in Journal of medical engineering & technology
Zayed A
(2011)
Speciation of oxaliplatin adducts with DNA nucleotides.
in Metallomics : integrated biometal science
Zayed A
(2011)
Determination of Pt-DNA adducts and the sub-cellular distribution of Pt in human cancer cell lines and the leukocytes of cancer patients, following mono- or combination treatments, by inductively-coupled plasma mass spectrometry
in International Journal of Mass Spectrometry
Yesufu A
(2007)
Meta-analyses of the effect of hormone treatment on cognitive function in postmenopausal women.
in Women's health (London, England)
Xin S
(2007)
Investigation of blood pulse PPG signal regulation on toe effect of body posture and lower limb height
in Journal of Zhejiang University-SCIENCE A
Shoeib T
(2012)
Interactions of oxaliplatin with the cytoplasmic thiol containing ligand glutathione.
in Metallomics : integrated biometal science
Rodrigues MA
(2008)
Gonadotropins and cognition in older women.
in Journal of Alzheimer's disease : JAD
Renault NK
(2011)
Multiple protein extract microarray for profiling human food-specific immunoglobulins A, M, G and E.
in Journal of immunological methods
Moustafa EM
(2013)
Oxaliplatin complexes with carnosine and its derivatives: in vitro cytotoxicity, mass spectrometric and computational studies with a focus on complex fragmentation.
in Metallomics : integrated biometal science
Meyer C
(2008)
Excessive exercise in the eating disorders: a need for less activity from patients and more from researchers...
in European eating disorders review : the journal of the Eating Disorders Association
| Description | Acting Chair of NHS i4i FPD1 Programme |
| Geographic Reach | National |
| Policy Influence Type | Participation in advisory committee |
| Description | Alzheimer's and Vascular Dementia in developing countries |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Citation in clinical reviews |
| Description | Excessive exercise and eating disorders |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Hormone replacement therapy and dementia |
| Geographic Reach | North America |
| Policy Influence Type | Citation in systematic reviews |
| Description | Independent Member of DOH Wellcome Health Innovation Challenge Fund Committee |
| Geographic Reach | National |
| Policy Influence Type | Participation in advisory committee |
| Description | Member of Macmillan's Work and Finance Workstream and the National Cancer Survivorship Initiative |
| Geographic Reach | National |
| Policy Influence Type | Participation in advisory committee |
| Description | National Measurement Strategy Working Party for Chemistry and Biology |
| Geographic Reach | National |
| Policy Influence Type | Participation in advisory committee |
| Description | A novel basophil-microarray device to detect allergic sensitization |
| Amount | £20,000 (GBP) |
| Organisation | Loughborough University |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 08/2009 |
| End | 08/2010 |
| Description | ART Project Award - Hormones, Cognition and Dementia Expert Meeting |
| Amount | £2,000 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2007 |
| End | 04/2007 |
| Description | Academy Award via Leicestershire Partnership NHS Trust - LUCRED |
| Amount | £26,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2008 |
| End | 11/2009 |
| Description | Alzheimer's Association USA Project Award - Hormones, Cognition and Dementia Expert Meeting |
| Amount | £1,530 (GBP) |
| Organisation | Alzheimer's Association |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 03/2007 |
| End | 04/2007 |
| Description | BBSRC funding (Development of a novel basophil-microarray device to detect allergic sensitization (follow on fund)) |
| Amount | £165,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2009 |
| End | 08/2010 |
| Description | Biomedical Research Unit - Lifestyle, Nutrition & Diet |
| Amount | £4,500,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2012 |
| End | 03/2017 |
| Description | EPSRC Health and Care Infrastructure Research and Innovation Centre (HaCIRIC) Project Grant - Hygiene Surveillance |
| Amount | £181,500 (GBP) |
| Funding ID | EP/D039614/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2008 |
| End | 03/2011 |
| Description | EPSRC Knowledge Transfer Award with Hygienics Biosecurity |
| Amount | £112,159 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2009 |
| End | 09/2011 |
| Description | EPSRC UK National Service for Computational Chemistry Software |
| Amount | £10,030 (GBP) |
| Funding ID | EP/J003921/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2011 |
| End | 01/2016 |
| Description | European Metrology Research Programme (EMRP) |
| Amount | £114,856 (GBP) |
| Organisation | European Association of National Metrology Institutes (EURAMET) |
| Sector | Charity/Non Profit |
| Country | Germany |
| Start | 12/2012 |
| End | 05/2014 |
| Description | FP7 - BIOMAP |
| Amount | € 210,092 (EUR) |
| Funding ID | 272957 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 03/2012 |
| End | 03/2014 |
| Description | FP7 - The One Study |
| Amount | £132,559 (GBP) |
| Funding ID | 260687 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 11/2010 |
| End | 10/2015 |
| Description | Faculty Research Award - Hormones, Cognition and Dementia Expert Meeting |
| Amount | £2,000 (GBP) |
| Organisation | Loughborough University |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2007 |
| End | 04/2007 |
| Description | HOPE Against Cancer Award - towards personalised chemotherapy |
| Amount | £15,000 (GBP) |
| Organisation | Hope Against Cancer (Rutland and Leicestershire) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2010 |
| End | 11/2012 |
| Description | Innovative Award |
| Amount | £13,672 (GBP) |
| Organisation | Royal Osteoporosis Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2012 |
| End | 10/2013 |
| Description | Knowledge Transfer Partnership - Bio-Imaging |
| Amount | £96,619 (GBP) |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2012 |
| End | 03/2014 |
| Description | MRC NPRI Grant (Sedentary Time and Diabetes) |
| Amount | £577,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2010 |
| End | 02/2013 |
| Description | NIHR RCT of Peripheral Arterial Disease Detector |
| Amount | £400,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2008 |
| End | 03/2010 |
| Description | NIHR RCT of Peripheral Arterial Disease Detector - follow on grant |
| Amount | £30,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2010 |
| End | 01/2012 |
| Description | New Dynamics of Ageing - AHRC |
| Amount | £25,344 (GBP) |
| Organisation | Arts & Humanities Research Council (AHRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2008 |
| End | 12/2011 |
| Description | New Dynamics of Ageing - BBSRC |
| Amount | £30,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2008 |
| End | 12/2011 |
| Description | New Dynamics of Ageing - EPSRC |
| Amount | £30,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2008 |
| End | 12/2011 |
| Description | New Dynamics of Ageing - ESRC |
| Amount | £30,000 (GBP) |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2008 |
| End | 12/2011 |
| Description | New Dynamics of Ageing - MRC |
| Amount | £30,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2008 |
| End | 12/2011 |
| Description | PhD Studentship - Hormones, Cognition and Dementia/Loughborough University |
| Amount | £42,000 (GBP) |
| Organisation | Loughborough University |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2010 |
| End | 09/2013 |
| Description | PhD Studentship - Influence of exercise and vitamin D status on bone health |
| Amount | £50,000 (GBP) |
| Organisation | Loughborough University |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2008 |
| End | 09/2011 |
| Description | PhD Studentship - Personalised Chemotherapy/Loughborough University |
| Amount | £55,000 (GBP) |
| Organisation | Loughborough University |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2010 |
| End | 09/2013 |
| Description | PhD Studentship - VOC Homeostasis in humans |
| Amount | £50,000 (GBP) |
| Organisation | Loughborough University |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2009 |
| End | 10/2012 |
| Description | Project Grant - Description and monitoring of Depok as an age friendly city/University of Indonesia |
| Amount | £72,061 (GBP) |
| Organisation | University of Indonesia |
| Sector | Academic/University |
| Country | Indonesia |
| Start | 09/2010 |
| End | 08/2011 |
| Description | Project Grant - Return to work tool for colorectal cancer patients/Macmillan Cancer Support |
| Amount | £50,000 (GBP) |
| Organisation | Macmillan Cancer Support |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2010 |
| End | 05/2011 |
| Description | Project Grant - Tofu and tempeh can affect cognitive decline/University of Indonesia |
| Amount | £14,412 (GBP) |
| Organisation | University of Indonesia |
| Sector | Academic/University |
| Country | Indonesia |
| Start | 09/2010 |
| End | 06/2011 |
| Description | RCT of Psychological Treatment for compulsive exercise within ED patients |
| Amount | £301,300 (GBP) |
| Organisation | Australian Institute of Health and Welfare |
| Sector | Public |
| Country | Australia |
| Start | 11/2009 |
| End | 04/2014 |
| Description | Young Investigator Award |
| Amount | £300 (GBP) |
| Organisation | Royal Osteoporosis Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2012 |
| End | 08/2012 |
| Description | iNet Higher Education Collaboration Fund - towards personalised chemotherapy |
| Amount | £28,500 (GBP) |
| Organisation | Loughborough University |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2009 |
| End | 02/2010 |
| Title | Basic method for diagnosis of Exercise Induced Bronchoconstriction |
| Description | Basic method for diagnosis of Exercise Induced Bronchoconstriction via eucapnic voluntary hyperventilation |
| Type Of Material | Physiological assessment or outcome measure |
| Provided To Others? | No |
| Impact | The associated researchers are registered with UK Sport and the English Institute of Sport as being able to screen athletes for EIB |
| Title | Collaborative interactive visualisation of medical imagery |
| Description | A sophisticated visualisation system that permits local and distributed viewing of medical data. It was possible to demonstrate the visualisation of medical imagery on a PDA or mobile phone device at a distance from the source of the data. Online access was demonstrated from the USA back to the UK and involved real-time interaction with the medical data set. Novel techniques have also been developed for dealing with the processing, management and distribution of medical imagery so that interactive real-time stereographic display techniques can be used remotely from the data source. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2008 |
| Provided To Others? | Yes |
| Impact | One peer-reviewed publication; three presentations at International Conferences; second prize in Royal Academy of Engineering ERA Foundation Entrepreneurs Award. |
| Title | Development of predictive assays for the efficacy or toxicity of Pt-based drugs |
| Description | Determination of Pt-DNA adduct formation in patients undergoing Pt-based chemotherapy; determination of partitioning of Pt-based drugs in cancer cell lines and white blood cells from patients; methodology for speciation of Pt-DNA adducts. Methods developed on cancer cell lines and then applied to white blood cells of patients attending oncology clinic - predicting efficacy/toxicity as a step towards personalised chemotherapy. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2010 |
| Provided To Others? | Yes |
| Impact | Indicative evidence obtained that assays have potential for predicting patient outcomes. |
| Title | Identification in human populations of both forms of interleukin-6 |
| Description | Venous samples and skeletal muscle samples extracted from healthy volunteers after a bout of exercise when glucose uptake is known to be stimulated. Study demonstrated for the first time that circulating levels of interleukin-6 and -6R complex are increased in response to acute exercise in young males. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | Study demonstrated for the first time that circulating levels of interleukin-6 and -6R complex are increased in response to acute exercise in young males. In addition it was possible to identify primers, which in skeletal muscle differentiated the two isoforms of the IL-6 receptor. Two grants subsequently awarded 1: MRC NPRI grant "An intervention to decrease sedentary behaviour in young adults at risk of type 2 diabetes mellitus" 2: MRC (IDBA) "Novel approaches to the early detection of cardiac disfunction and health behaviours in the young with T2DM" |
| Title | Return to work information tool |
| Description | Return to work information tool for patients of colorectal cancer and their employers - additional funding from Macmillan Cancer Support has enabled continuing development of this tool. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | Presentation of the tool to Macmillan, Bowel Cancer UK, and oncologists at Leicester Royal Infirmary and Birmingham Heartlands Hospital. Lead Researcher is now a member of Macmillan's "Work and Finance" Workstream and the National Cancer Survivorship Initiative. |
| Description | Collaborative interactive visualisation of medical imagery |
| Organisation | University Hospitals of Leicester NHS Trust |
| Department | Department of Radiology |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Development of visualisation system that permits local and distributed viewing of medical imagery. |
| Collaborator Contribution | Hosting of secondment of two research students from Loughborough. Access to data, facilities and expertise. |
| Impact | Publications and dissemination to non-academic audiences. Awards and recognition. Research materials. |
| Start Year | 2007 |
| Description | Compulsive exercise and eating disorders |
| Organisation | Beating Eating Disorders (beat) |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Supervision of research student seconded to Leicester. Development of new psychological treatment for compulsive exercise within eating disordered patients and development of treatment manual. |
| Collaborator Contribution | Hosting of secondment of research student from Loughborough. Access to patients, patient data and expertise. Participation in treatment trial. Presentation at workshops.Access to patients, patient data and expertise. Participation in treatment trial. Presentation at workshops.Presentation at workshops. Dissemination of material. |
| Impact | £327,300 further funding. Treatment trial commenced 2009. Treatment group established at Leicester. Publications and dissemination to non-academic audiences. |
| Start Year | 2007 |
| Description | Compulsive exercise and eating disorders |
| Organisation | Leicestershire Partnership NHS Trust |
| Department | Eating Disorders Service |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Supervision of research student seconded to Leicester. Development of new psychological treatment for compulsive exercise within eating disordered patients and development of treatment manual. |
| Collaborator Contribution | Hosting of secondment of research student from Loughborough. Access to patients, patient data and expertise. Participation in treatment trial. Presentation at workshops.Access to patients, patient data and expertise. Participation in treatment trial. Presentation at workshops.Presentation at workshops. Dissemination of material. |
| Impact | £327,300 further funding. Treatment trial commenced 2009. Treatment group established at Leicester. Publications and dissemination to non-academic audiences. |
| Start Year | 2007 |
| Description | Compulsive exercise and eating disorders |
| Organisation | University of Sydney |
| Department | School of Psychology |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Supervision of research student seconded to Leicester. Development of new psychological treatment for compulsive exercise within eating disordered patients and development of treatment manual. |
| Collaborator Contribution | Hosting of secondment of research student from Loughborough. Access to patients, patient data and expertise. Participation in treatment trial. Presentation at workshops.Access to patients, patient data and expertise. Participation in treatment trial. Presentation at workshops.Presentation at workshops. Dissemination of material. |
| Impact | £327,300 further funding. Treatment trial commenced 2009. Treatment group established at Leicester. Publications and dissemination to non-academic audiences. |
| Start Year | 2007 |
| Description | Computer vision system for assessment of total hip replacements |
| Organisation | Glenfield Hospital |
| Department | Department of Surgery |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Investigated a range of potential algorithms for the automatic identification of failing artificial hip joints which are then being compared to expert surgeon's opinions. This is ongoing. |
| Collaborator Contribution | Sourced exemplar patient hip replacement radiographs; prior to surgery, post surgery and on subsequent follow-ups which have been used to investigate suitable algorithms for automatic detection of joint wear in replacement hip joints. Facilitiated access to a range of artificial hips for digitisation purposes. |
| Impact | PhD was successfully awarded in 2013 for thesis entitled 'Medical image processing: application in ophthalmology and total hip replacement' |
| Start Year | 2009 |
| Description | Corneal strain mapper |
| Organisation | De Montfort University |
| Department | School of Design |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Development of non-invasive method of assessing the level of strain in the human cornea. |
| Collaborator Contribution | Access to patient data. Access to expertise and facilities. Production of a rapid manufactured working chassis of the corneal strain mapper instrument into which all the optical components, camera and laser can be inserted. |
| Impact | Clinical trial. Awards and recognition. Further funding. New product/invention. |
| Description | Corneal strain mapper |
| Organisation | St Thomas' Hospital |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Development of non-invasive method of assessing the level of strain in the human cornea. |
| Collaborator Contribution | Access to patient data. Access to expertise and facilities. Production of a rapid manufactured working chassis of the corneal strain mapper instrument into which all the optical components, camera and laser can be inserted. |
| Impact | Clinical trial. Awards and recognition. Further funding. New product/invention. |
| Description | Exercise tolerance in COPD |
| Organisation | University Hospitals of Leicester NHS Trust |
| Department | Department of Respiratory Medicine |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Joint supervision of joint MD/PhD |
| Collaborator Contribution | MOD funded research project to investigate the phenotype of Exercise Induced Bronchoconstriction in a fit and healthy population. Access to subject data. |
| Impact | Presentations of prelim data at national annual conferences Dissemination to various non-academic audiences (sport NGBs) |
| Start Year | 2008 |
| Description | Hormones, Cognition and Dementia |
| Organisation | Oxford University Hospitals NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Hosting and lead scientific contribution to international expert meeting. Facilitation of multi-disciplinary scientific exchange in basic and clinical research to develop new hypotheses related to hormones, cognition and dementia. Analysis of data. |
| Collaborator Contribution | participation in expert international meeting subsequent research collaboration and contribution to bookAccess to data, facilities and expertise. Collaboration on book and publications.Access to data, facilities and expertise. Collaboration on book and publications.Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. |
| Impact | Book published 2009. International expert meeting series established. Publications and dissemination to non-academic audiences. |
| Description | Hormones, Cognition and Dementia |
| Organisation | Stanford University |
| Department | Department of Health Research and Policy |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Hosting and lead scientific contribution to international expert meeting. Facilitation of multi-disciplinary scientific exchange in basic and clinical research to develop new hypotheses related to hormones, cognition and dementia. Analysis of data. |
| Collaborator Contribution | participation in expert international meeting subsequent research collaboration and contribution to bookAccess to data, facilities and expertise. Collaboration on book and publications.Access to data, facilities and expertise. Collaboration on book and publications.Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. |
| Impact | Book published 2009. International expert meeting series established. Publications and dissemination to non-academic audiences. |
| Description | Hormones, Cognition and Dementia |
| Organisation | University of Cambridge |
| Department | MRC Biostatistics Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Hosting and lead scientific contribution to international expert meeting. Facilitation of multi-disciplinary scientific exchange in basic and clinical research to develop new hypotheses related to hormones, cognition and dementia. Analysis of data. |
| Collaborator Contribution | participation in expert international meeting subsequent research collaboration and contribution to bookAccess to data, facilities and expertise. Collaboration on book and publications.Access to data, facilities and expertise. Collaboration on book and publications.Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. |
| Impact | Book published 2009. International expert meeting series established. Publications and dissemination to non-academic audiences. |
| Description | Hormones, Cognition and Dementia |
| Organisation | University of Indonesia |
| Department | Center for Health Research |
| Country | Indonesia |
| Sector | Academic/University |
| PI Contribution | Hosting and lead scientific contribution to international expert meeting. Facilitation of multi-disciplinary scientific exchange in basic and clinical research to develop new hypotheses related to hormones, cognition and dementia. Analysis of data. |
| Collaborator Contribution | participation in expert international meeting subsequent research collaboration and contribution to bookAccess to data, facilities and expertise. Collaboration on book and publications.Access to data, facilities and expertise. Collaboration on book and publications.Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. |
| Impact | Book published 2009. International expert meeting series established. Publications and dissemination to non-academic audiences. |
| Description | Hormones, Cognition and Dementia |
| Organisation | University of Leicester |
| Department | Department of Genetics |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Hosting and lead scientific contribution to international expert meeting. Facilitation of multi-disciplinary scientific exchange in basic and clinical research to develop new hypotheses related to hormones, cognition and dementia. Analysis of data. |
| Collaborator Contribution | participation in expert international meeting subsequent research collaboration and contribution to bookAccess to data, facilities and expertise. Collaboration on book and publications.Access to data, facilities and expertise. Collaboration on book and publications.Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. |
| Impact | Book published 2009. International expert meeting series established. Publications and dissemination to non-academic audiences. |
| Description | Hormones, Cognition and Dementia |
| Organisation | University of Pittsburgh |
| Department | Department of Pharmaceutical Sciences |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Hosting and lead scientific contribution to international expert meeting. Facilitation of multi-disciplinary scientific exchange in basic and clinical research to develop new hypotheses related to hormones, cognition and dementia. Analysis of data. |
| Collaborator Contribution | participation in expert international meeting subsequent research collaboration and contribution to bookAccess to data, facilities and expertise. Collaboration on book and publications.Access to data, facilities and expertise. Collaboration on book and publications.Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. |
| Impact | Book published 2009. International expert meeting series established. Publications and dissemination to non-academic audiences. |
| Description | Hormones, Cognition and Dementia |
| Organisation | University of Southern California |
| Department | School of Pharmacy USC |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Hosting and lead scientific contribution to international expert meeting. Facilitation of multi-disciplinary scientific exchange in basic and clinical research to develop new hypotheses related to hormones, cognition and dementia. Analysis of data. |
| Collaborator Contribution | participation in expert international meeting subsequent research collaboration and contribution to bookAccess to data, facilities and expertise. Collaboration on book and publications.Access to data, facilities and expertise. Collaboration on book and publications.Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. |
| Impact | Book published 2009. International expert meeting series established. Publications and dissemination to non-academic audiences. |
| Description | Hormones, Cognition and Dementia |
| Organisation | University of Wisconsin-Madison |
| Department | School of Medicine and Public Health |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Hosting and lead scientific contribution to international expert meeting. Facilitation of multi-disciplinary scientific exchange in basic and clinical research to develop new hypotheses related to hormones, cognition and dementia. Analysis of data. |
| Collaborator Contribution | participation in expert international meeting subsequent research collaboration and contribution to bookAccess to data, facilities and expertise. Collaboration on book and publications.Access to data, facilities and expertise. Collaboration on book and publications.Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. Access to data, facilities and expertise. Collaboration on book and publications. |
| Impact | Book published 2009. International expert meeting series established. Publications and dissemination to non-academic audiences. |
| Description | Hospital ward deep clean evaluation |
| Organisation | 3M |
| Department | 3M Healthcare |
| Country | United States |
| Sector | Private |
| PI Contribution | Evaluation of the effectiveness of the deep clean process at UHL in reducing microbiological contamination and quantifying rates of recolonisation. |
| Collaborator Contribution | Access to wards before and after deep cleaning. Access to staff. Presentations by Directors of Nursing and Infection Control.In-kind contribution circa £7k. Provision of bioluminesence technology to evaluate deep clean. Access to facilities and staff.Access to facilities and expertise. |
| Impact | Dissemination to non-academic audiences including DOH. Research materials. Further funding of £293,659. |
| Start Year | 2008 |
| Description | Hospital ward deep clean evaluation |
| Organisation | Hygienics Biosecurity Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Evaluation of the effectiveness of the deep clean process at UHL in reducing microbiological contamination and quantifying rates of recolonisation. |
| Collaborator Contribution | Access to wards before and after deep cleaning. Access to staff. Presentations by Directors of Nursing and Infection Control.In-kind contribution circa £7k. Provision of bioluminesence technology to evaluate deep clean. Access to facilities and staff.Access to facilities and expertise. |
| Impact | Dissemination to non-academic audiences including DOH. Research materials. Further funding of £293,659. |
| Start Year | 2008 |
| Description | Hospital ward deep clean evaluation |
| Organisation | University Hospitals of Leicester NHS Trust |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Evaluation of the effectiveness of the deep clean process at UHL in reducing microbiological contamination and quantifying rates of recolonisation. |
| Collaborator Contribution | Access to wards before and after deep cleaning. Access to staff. Presentations by Directors of Nursing and Infection Control.In-kind contribution circa £7k. Provision of bioluminesence technology to evaluate deep clean. Access to facilities and staff.Access to facilities and expertise. |
| Impact | Dissemination to non-academic audiences including DOH. Research materials. Further funding of £293,659. |
| Start Year | 2008 |
| Description | Lab-based In-vitro Chemotherapy Assay |
| Organisation | East Midlands Medilink |
| Department | Healthcare & Bioscience iNet |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Development of lab-based in-vitro test to determine individual patient response to Chemotherapy. |
| Collaborator Contribution | Access to patients and patient data. Access to expertise and facilities. Lead partner in clinical trial.Development of new methodologies for monitoring drug performance. Access to expertise and facilities. |
| Impact | Further funding. Dissemination to non-academic audiences. Extensive media coverage. Awards and recognition. Research materials. |
| Start Year | 2007 |
| Description | Lab-based In-vitro Chemotherapy Assay |
| Organisation | Hope Against Cancer (Rutland and Leicestershire) |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Development of lab-based in-vitro test to determine individual patient response to Chemotherapy. |
| Collaborator Contribution | Access to patients and patient data. Access to expertise and facilities. Lead partner in clinical trial.Development of new methodologies for monitoring drug performance. Access to expertise and facilities. |
| Impact | Further funding. Dissemination to non-academic audiences. Extensive media coverage. Awards and recognition. Research materials. |
| Start Year | 2007 |
| Description | Lab-based In-vitro Chemotherapy Assay |
| Organisation | Laboratory of the Government Chemist (LGC) Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Development of lab-based in-vitro test to determine individual patient response to Chemotherapy. |
| Collaborator Contribution | Access to patients and patient data. Access to expertise and facilities. Lead partner in clinical trial.Development of new methodologies for monitoring drug performance. Access to expertise and facilities. |
| Impact | Further funding. Dissemination to non-academic audiences. Extensive media coverage. Awards and recognition. Research materials. |
| Start Year | 2007 |
| Description | Lab-based In-vitro Chemotherapy Assay |
| Organisation | Leicester Royal Infirmary |
| Department | Department of Oncology |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Development of lab-based in-vitro test to determine individual patient response to Chemotherapy. |
| Collaborator Contribution | Access to patients and patient data. Access to expertise and facilities. Lead partner in clinical trial.Development of new methodologies for monitoring drug performance. Access to expertise and facilities. |
| Impact | Further funding. Dissemination to non-academic audiences. Extensive media coverage. Awards and recognition. Research materials. |
| Start Year | 2007 |
| Description | Lower back injury detection and diagnosis using MRI |
| Organisation | Leicester Royal Infirmary |
| Department | Department of Radiology |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | A Loughborough lecturer in Biomechanics supervised the secondment of a research student who was seconded to work with a Consultant Radiologist at LRI to develop an understanding of the methodology used to identify and diagnose lower back injuries (highly prevalent in elite fast bowlers) using MRI. |
| Collaborator Contribution | Hosting of secondment of a research student from Loughborough. Access to facilities and expertise. |
| Impact | Dissemination to non-academic audiences |
| Start Year | 2009 |
| Description | Managing colorectal cancer and employment |
| Organisation | Leicester Royal Infirmary |
| Department | Department of Oncology |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Loughborough senior lecturer supervised research student who was seconded to work with Oncologists at LRI. |
| Collaborator Contribution | Access to patients.Access to staff, invitation to present findings to charity and key supporters. |
| Impact | New product (return to work information tool). Awards and recognition. Dissemination to non-academic audiences. |
| Start Year | 2008 |
| Description | Managing colorectal cancer and employment |
| Organisation | Macmillan Cancer Support |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Loughborough senior lecturer supervised research student who was seconded to work with Oncologists at LRI. |
| Collaborator Contribution | Access to patients.Access to staff, invitation to present findings to charity and key supporters. |
| Impact | New product (return to work information tool). Awards and recognition. Dissemination to non-academic audiences. |
| Start Year | 2008 |
| Description | Peripheral Arterial Disease Detector (PADD) |
| Organisation | Leeds Teaching Hospitals NHS Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Development of Peripheral Arterial Disease Detector (PADD). |
| Collaborator Contribution | Access to expertise. Access to patients, patient data and facilities. Access to primary care workers. Leading a multi-site clinical study.Access to expertise. Access to patients, patient data and facilities. Access to primary care workers. Participation in a multi-site clinical study.Access to expertise. Access to patients, patient data and facilities. Access to primary care workers. Participation in a multi-site clinical study. |
| Impact | £400,000 further funding (DOH HTD grant). Publications and dissemination to non-academic audiences. UK and European patent. Awards and recognition. Multi-centre clinical trial commenced 2008. |
| Start Year | 2006 |
| Description | Peripheral Arterial Disease Detector (PADD) |
| Organisation | Royal Free Hospital |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Development of Peripheral Arterial Disease Detector (PADD). |
| Collaborator Contribution | Access to expertise. Access to patients, patient data and facilities. Access to primary care workers. Leading a multi-site clinical study.Access to expertise. Access to patients, patient data and facilities. Access to primary care workers. Participation in a multi-site clinical study.Access to expertise. Access to patients, patient data and facilities. Access to primary care workers. Participation in a multi-site clinical study. |
| Impact | £400,000 further funding (DOH HTD grant). Publications and dissemination to non-academic audiences. UK and European patent. Awards and recognition. Multi-centre clinical trial commenced 2008. |
| Start Year | 2006 |
| Description | Peripheral Arterial Disease Detector (PADD) |
| Organisation | University Hospitals of Leicester NHS Trust |
| Department | Department of Diabetic Medicine |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Development of Peripheral Arterial Disease Detector (PADD). |
| Collaborator Contribution | Access to expertise. Access to patients, patient data and facilities. Access to primary care workers. Leading a multi-site clinical study.Access to expertise. Access to patients, patient data and facilities. Access to primary care workers. Participation in a multi-site clinical study.Access to expertise. Access to patients, patient data and facilities. Access to primary care workers. Participation in a multi-site clinical study. |
| Impact | £400,000 further funding (DOH HTD grant). Publications and dissemination to non-academic audiences. UK and European patent. Awards and recognition. Multi-centre clinical trial commenced 2008. |
| Start Year | 2006 |
| Description | Role of interleukin-6 and cognate receptors in insulin resistance in T2D |
| Organisation | University Hospitals of Leicester NHS Trust |
| Department | Department of Diabetic Medicine |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Recruitment of subject group, subsequent testing, joint analysis of data with Leicester researchers. |
| Collaborator Contribution | Access to data and facilities |
| Impact | Further MRC grants including NPRI grant. New research materials. |
| Start Year | 2008 |
| Description | Vitamin D and Bone Health |
| Organisation | Leicester Royal Infirmary |
| Department | Department of Radiology |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Examination of the impact of exercise (and also vitamin D status) on bone structural parameters and neuro-muscular function in older men. Lead of multi-disciplinary collaborative group. |
| Collaborator Contribution | Access to facilities and expertise. Access to patients and patient data.Access to facilities and expertise. Access to patients and patient data. |
| Impact | Further funding for PhD studentship and further funding for collaborative work with new partners (Cambridge). Dissemination to clinical and non-academic audiences. |
| Start Year | 2008 |
| Description | Vitamin D and Bone Health |
| Organisation | Royal Derby Hospital |
| Department | Department of Rheumatology |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Examination of the impact of exercise (and also vitamin D status) on bone structural parameters and neuro-muscular function in older men. Lead of multi-disciplinary collaborative group. |
| Collaborator Contribution | Access to facilities and expertise. Access to patients and patient data.Access to facilities and expertise. Access to patients and patient data. |
| Impact | Further funding for PhD studentship and further funding for collaborative work with new partners (Cambridge). Dissemination to clinical and non-academic audiences. |
| Start Year | 2008 |
| Description | Vitamin D and Bone Health |
| Organisation | University Hospitals of Leicester NHS Trust |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Worked together on collaborative grant proposal |
| Collaborator Contribution | Worked together on collaborative grant proposal |
| Impact | Collaborative grant proposal for funding by National Osteoporosis Society was successful and research is ongoing |
| Start Year | 2012 |
| Description | Vitamin D and Bone Health |
| Organisation | University of Cambridge |
| Department | Department of Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Worked together on collaborative grant proposal |
| Collaborator Contribution | Worked together on collaborative grant proposal |
| Impact | Collaborative grant proposal for funding by National Osteoporosis Society was successful and research is ongoing |
| Start Year | 2012 |
| Description | Vitamin D and Bone Health |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Examination of the impact of exercise (and also vitamin D status) on bone structural parameters and neuro-muscular function in older men. Lead of multi-disciplinary collaborative group. |
| Collaborator Contribution | Access to facilities and expertise. Access to patients and patient data.Access to facilities and expertise. Access to patients and patient data. |
| Impact | Further funding for PhD studentship and further funding for collaborative work with new partners (Cambridge). Dissemination to clinical and non-academic audiences. |
| Start Year | 2008 |
| Title | Multiple sensor, multiple posture sensing for assessing a subject's circulatory system |
| Description | The clinical work enabled by a DoH HTD grant led to the discovery which has enabled a broadening of the company's IP portfolio and provided further protection to the core invention. The novelty arises from the use of multiple sensors to provide further data to derive a more specific assessment of the condition of a patient's circulatory system. |
| IP Reference | US8491486 |
| Protection | Patent granted |
| Year Protection Granted | 2013 |
| Licensed | No |
| Impact | Dialog is in the process of developing a new device based upon this discovery. The technology has not yet been licensed. |
| Title | Basophil-linked protein array for allergy diagnosis |
| Description | Our basophil array technology has been developed from a prototype (published in 2007) to a technique that is now amenable to full automation. |
| Type | Diagnostic Tool - Non-Imaging |
| Current Stage Of Development | Refinement. Non-clinical |
| Year Development Stage Completed | 2009 |
| Development Status | On hold |
| Impact | We are now able to test clinical samples to validate the technology by comparing it against the gold standards in allergy diagnosis. |
| Title | Corneal Strain Mapper |
| Description | The corneal Strain Mapper is a laser interferometer which enables a whole field image of the strain induced on the human cornes as a consequence of pressure fluctuation. The novel radial interferometer provides an immediate quantitative strain image of the cornea and is able to provide anomolous data pertinent to surgical insult. |
| Type | Support Tool - For Fundamental Research |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2009 |
| Development Status | Under active development/distribution |
| Impact | We have been able to determine changes in elastic stiffness in a range of adult cornea, 20-100 years, to define age related stiffening of the cornea, hitherto unknown yet assumed to be age related softening! |
| Title | Lab-based in-vitro test to determine individual patient response to chemotherapy |
| Description | A lab-based in-vitro test, based on inductively-coupled-plasma-mass-spectrometry, has been developed that enables direct measurement of the binding of Pt-based chemotherapeutic drugs to their prime pharmacaological target, DNA. The test enables these Pt-DNA adducts to be measured at 1 adduct in 2 x 106 base pairs on as little as 10 ?g DNA. The pilot clinical trial has demonstrated that the test can be applied to patients undergoing chemotherapy and that the data may eventually be used as a basis for dose modification to improve efficacy and/or reduce toxicity. Futher development has enabled the distribution of the drug in the major cellular compartments to be quantified and the effect of combination therapies, such as FOLFOX, to be studied. The ultimate aim is personalisation of Pt-based chemotherapy. |
| Type | Diagnostic Tool - Non-Imaging |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2009 |
| Development Status | On hold |
| Impact | This programme is developing rapidly and subsequent to the Da Vinci Award (via IDBA MRC grand) has received further funding from iNET £28750 and Hope Against Cancer £15000. A lecture by Dr Sharp at the 2009 British Science Festival in Surrey received wide national and local press coverage. The original team at Loughborough and Leicester has now been expanded to include colleagues from LGC Ltd, Teddington, the UK's lead National Measurement Institute for chemical and biological measurements. The new collaboration is to employ emerging techniques in genetics to screen patients for chemosensitivity and to use genomic assays to study drug binding and gene targeting. The data from mass spectrometry and genomic testing are being combined in a programme named 'Per-Chemo' which has been short-listed for £1.05M support from the Health Innovation Challenge Fund sponsored by the Department of Health and Wellcome Trust. |
| Title | New psychological treatment for compulsive exercise with eating disordered patients |
| Description | The development and implementation of a manualised treatment manual involving novel psychological intervention for compulsive exercise within eating disordered patients. Currently subject to international, multi-centre RCT. |
| Type | Preventative Intervention - Behavioural risk modification |
| Current Stage Of Development | Early clinical assessment |
| Year Development Stage Completed | 2009 |
| Development Status | Under active development/distribution |
| Impact | £301,300 funding for a treatment trial from the Australian Institute of Health. Based on the development of this new treatment, a treatment group is now being run at Leicester Eating Disorder Service and a series of workshops are being delivered (5 delivered to date). One peer-reviewed publication. Presentations at two International Conferences. |
| Title | Peripheral arterial disease detector (PADD) |
| Description | Padd™ is a non-invasive medical device for rapid and simple assessment of Peripheral Arterial Disease using low power near infra-red light to assess blood volume changes in the foot, before and after raising the leg. Optical sensors are applied to the foot and 30 second readings are taken before and after raising the leg on a 30cm (12") calf support. A second device for post-operative monitoring of peripheral intervention is also under development. |
| Type | Diagnostic Tool - Non-Imaging |
| Current Stage Of Development | Small-scale adoption |
| Year Development Stage Completed | 2009 |
| Development Status | Under active development/distribution |
| Impact | Department of Health HTD £400k grant awarded to implement multi-centre clinical trial. PADD patented in the UK and Europe and notification of 'intent to grant' in China. Four peer-reviewed publications and presentation at International Conference. PADD is now reimbursed under US health insurance schemes. |
| Title | The Loughborough Occupational Impact of Sleep Scale |
| Description | Outcome metric for assessing the occupational impact of insomnia, sleep apnoea and excessive daytime sleepiness. The Scale has been presented at conferences in the USA and Europe and will be published shortly in a peer reviewed journal (currently in press) - recent funding from NIHR (programme development) and ESRC (Subjective Wellbeing and Public Policy - the role of work). |
| Type | Support Tool - For Fundamental Research |
| Current Stage Of Development | Wide-scale adoption |
| Year Development Stage Completed | 2010 |
| Development Status | Under active development/distribution |
| Impact | The Scale has already been adopted into a NIHR protocol being prepared by researchers at the University of Pennsylvania and by the cross-council funded NDA "working late" project. Further adoption is anticipated following publication in a peer reviewed journal in early 2011. |
| Description | Analytical Chemistry from Laboratory to Clinic - RSC Scotland |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited lecture to Royal Society of Chemistry Scottish Region. Publicising work to the UK Scientific Community. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Da Vinci Health Technology Innovation Awards |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Flagship dissemination event: The primary objective of the Da Vinci Awards is to reward early stage research projects that are cross-disciplinary and ground breaking. The prize funding has been a vital catalyst in enabling the projects to secure further grant funding to commercialise the technology. The audience for this event is comprised of researchers, clinicians and senior representatives from the region's health and bioscience organisations, hospitals and research institutions. - February 2007 (£15K prize fund), 90 attendees - November 2008 (£47k private and public sector sponsorship leveraged enabling prize fund to be raised to £45k for three distinct awards), 120 attendees - 2010 event confirmed for 22 March. Over £30k public and private sector sponsorship leveraged to date and £45k prize fund guaranteed. - Four projects shortlisted for the awards (including the three winning projects) have leveraged to date over £900K further funding (20 x the value of the total prize fund). Details follow: Newcomer winner: Lab-based in-vitro test to determine individual patient response to chemotherapy £15k Hope Against Cancer Research Grant £29k iNet Collaborative Grant £245k LGC validation of metallo-drug DNA assays using isotope dilution mass spectrometry £1M Wellcome / DOH bid submitted September 2009 (direct follow on from Da Vinci & iNet) British Science Festival presentation (September 2009), national media coverage Breakthrough winner: A lab-based in vitro test to mimic human allergic response £20k University of Nottingham pathfinder funding £165k BBSRC funding towards commercialisation (Follow-on-fund) Clinical Impact winner: Corneal Strain Mapper £20k EU / emda grant to enable the production of a prototype instrument scheduled for completion October 2009, field trials to follow shortly after. Clinical Impact highly commended: Nottingham Cataract Device £300k Wellcome Trust Translational Award to accelerate commercialisation. |
| Year(s) Of Engagement Activity | 2007,2008 |
| Description | Electronic media coverage of Personalised Chemotherapy Research |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Articles appeared as follows: 09/09/09 Financial Times on-line Science Blog 09/09/09 Yahoo News 10/09/09 Daily Mail on-line See above |
| Year(s) Of Engagement Activity | 2009 |
| Description | Elemental Mass Spectrometry - Providing new insights in bio-science |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Invited lecture at the MRC Human Nutrition Research Centre, Elsie Widdowson Laboratory, Cambridge Publicising work to PhD students and staff at another University. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Elemental Mass Spectrometry from Laboratory to Clinic |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Invited lecture at the joint Symposia of the Royal Society of Chemists and American Chemical Society at the FACSS Conference SCIX 2012, Kansas City, 1-2 October 2012. The Symposia were aimed at academic and industrial scientists with an interest in the use of analytical science to tackle the global challenges in human health. Publicising work to the international scientific community. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Expert International Meeting - Hormones, Cognition and Dementia |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Expert meeting brought together world-renowned experts in basic and clinical research to develop new hypotheses Meeting initiated a two-yearly event with the next meeting held in Bali in 2008 and a future meeting to be held in Stanford, USA in 2010. Cambridge University Press book "Hormones, Cognition and Dementia" published October 2009. Eleven peer-reviewed publications. |
| Year(s) Of Engagement Activity | 2007 |
| Description | Film about Corneal Strain Mapper |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Short film for lay audience produced to describe the project, commissioned as part of the DaVinci Awards Clinical Impact first prize. Film used to engage research partners and stakeholders. Researchers have been awarded £20k EU Research funding to develop a stage two proto-type. |
| Year(s) Of Engagement Activity | 2008 |
| Description | Film about Personalised Chemotherapy Research |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | 2008 - short film for lay audience produced to describe the project, commissioned as part of the DaVinci Awards Newcomer first prize. Film used to engage research partners and stakeholders. Researchers have been awarded follow-on funding to further develop their technology. |
| Year(s) Of Engagement Activity | 2008 |
| Description | Films on Peripheral Arterial Disease Detector (PADD) |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Two-day filming by Canadian Discovery Channel and two-day filming by Australian TV Channel (for Beyond Tomorrow) of Peripheral Arterial Disease Detector inventor, collaborating clinicians and prospective patients Five minute feature film broadcast in Canada in 2008. Five minute feature film broadcast in Australia and New Zealand in 2008. |
| Year(s) Of Engagement Activity | 2007 |
| Description | From Laboratory to Clinic, Analytical Chemistry in Action |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Invited seminar for the Royal Society of Chemistry at the University of Strathclyde, November 2012 Publicising work to PhD Students and Staff at other Universities. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Hand function simulation project website submission |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Website description of project to develop an arthritis simulation glove to be used as an educational aid for health professionals, designers and within education Raised profile of Ergonomics and Safety Research Institute's expertise in the emerging field of wearable simulations |
| Year(s) Of Engagement Activity | 2008 |
| Description | Lecture at British Science Festival - Personalised Chemotherapy |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Lecture on research to develop a lab-based in-vitro test to determine individual patient response to Chemotherapy Widespread coverage in national and regional press |
| Year(s) Of Engagement Activity | 2009 |
| Description | Media coverage of Personalised Chemotherapy Research |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Articles appeared as follows: 10/09/09 Daily Express 10/09/09 Pharmacy Europe 10/09/09 Platinum Europe 14/09/09 Herald Scotland 18/09/09 Loughborough Echo See above |
| Year(s) Of Engagement Activity | 2009 |
| Description | National Osteoporosis Society Allied Health Professionals Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Health professionals |
| Results and Impact | TBC |
| Year(s) Of Engagement Activity | 2013 |
| Description | Presentation on Alzheimer's Research to Loughborough Rotarians |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Public engagement presentation on the determinants of risk factors for the metabolic syndrome None |
| Year(s) Of Engagement Activity | 2008 |
| Description | Presentation on modelling of cement position in vertebrae |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Oral discussion with Drugs Company representatives regarding modelling of cement position in vertebrae None |
| Year(s) Of Engagement Activity | 2009 |
| Description | Presentation to European Congress of Radiologists |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Presentation on effective understanding, analysis and delivery of complex medical imaging data via a ubiquitous visualisation system in a clinical environment None |
| Year(s) Of Engagement Activity | 2007 |
| Description | Presentation to GB Swimmers re EIB |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Presentation to elite swimmers regarding participation in investigative study to assess exercise induced bronchoconstriction (EIB) Researchers are now registered with UK Sport and the English Institute of Sport as being able to screen athletes for EIB |
| Year(s) Of Engagement Activity | 2008 |
| Description | Presentation to Industry on Personalised Chemotherapy Research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation to LGC, Teddington to discuss research on lab-based in-vitro test to determine individual patient response to Chemotherapy New methodologies for monitoring drug performance identifed to develop genomic assays for Pt drug efficacy. LGC awards £245k for validation of metallo-drug DNA assays using isotype dilution mass-spectrometry |
| Year(s) Of Engagement Activity | 2009 |
| Description | Presentations at Awards Events of Peripheral Arterial Disease Detector (PADD) |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Film showing/Presentation of Peripheral Arterial Disease Detector (PADD) as part of Awards Ceremony Peripheral Arterial Disease Detector (PADD) won first prize for Innovation in Development category at Lord Stafford Awards. Peripheral Arterial Disease Detector (PADD) shortlisted in spin-out category at Medilink Awards. |
| Year(s) Of Engagement Activity | 2007,2008 |
| Description | Presentations of Peripheral Arterial Disease Detector (PADD) for use in primary care at various clinical and healthcare industry events |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Presentation of PADD given at events in the UK, Germany and the USA to healthcare professionals and policymakers at all levels of responsibility from local to global. Raising awareness and profile of PADD. |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009 |
| Description | Presentations on Exercise Induced Bronchoconstriction (EIB) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Presentation regarding a novel assessment for Exercise Induced Bronchoconstriction (EIB) in elite athletes. Researchers are now registered with UK Sport and the English Institute of Sport as being able to screen athletes for EIB. |
| Year(s) Of Engagement Activity | 2008 |
| Description | Presentations on a work ability intervention for colorectal cancer patients |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Four presentations given to Macmillan Cancer Charity, Bowel Cancer UK and Oncologists at both Leicester Royal Infirmary and Birmingham Heartlands Hospital. Researcher is now a member of Macmillan's Work & Finance Workstream. Discussions underway with Macmillan as to the impact this study may have on existing policies on work and cancer. Development of a 'return to work' information tool for patients and employers. Access to patients and future work together at Leicester Royal Infirmary. |
| Year(s) Of Engagement Activity | 2008 |
| Description | Presentations on the evaluation of hospital ward deep-clean process |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Presentations given to EPSRC, the Health Protection Agency, the Dept of Health and various NHS Trusts. EPSRC funding HaCIRIC Research Award. Discussions ongoing with the Dept of Health on use of Statistical Process Control techniques for cleaning assurance in NHS Trusts. |
| Year(s) Of Engagement Activity | 2008 |
| Description | Public Lecture on Alzheimer's / Dementia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Public lectures in Leicester and Loughborough. Alzheimer's Research Trust Midlands Group initiated and a meeting is now held annually. |
| Year(s) Of Engagement Activity | 2008 |
| Description | Public Lecture on hospital acquired infections - Loughborough University |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Public engagement event as part of Loughborough University Centenary Open Day None |
| Year(s) Of Engagement Activity | 2009 |
| Description | Technology Demonstration to Radiologists at Leicester Hospital |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Health professionals |
| Results and Impact | Demonstration of collaborative interactive visualisation of medical imagery to Radiologists at Glenfield Hospital, Leicester New research collaboration initiated which is ongoing |
| Year(s) Of Engagement Activity | 2007 |
| Description | Towards Personalised Pt-based Chemotherapy - Cambridge |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited lecture at MRC Food Research Laboratory, Cambridge. Publicising work to scientists in the nutritional field. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Towards Personalised Pt-based Chemotherapy - Germany |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation to German ICP-MS Group, Berlin, of lab-based in-vitro test to determine individual patient response to Chemotherapy. Publicising work to European groups working in a similar field. |
| Year(s) Of Engagement Activity | 2010 |
| Description | Towards Personalised Pt-based Chemotherapy - RSC Western |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited lecture to Royal Society of Chemistry Western Region. Publicising work to the UK Scientific Community. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Towards Personalised Pt-based Chemotherapy - Zaragoza |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation to the 2011 winter Conference on Plasma Spectrochemistry, Zarazoga. Publicising work to the international scientific community. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Two films about lab-based in-vitro test to mimic human allergic response |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | 2008 - short film for lay audience produced to describe the project, commissioned as part of the DaVinci Awards Breakthrough Technology first prize. 2009 - a CGI animated short movie was produced specifically to explain the principle of the technology. Both films used to engage research partners and stakeholders. Researchers have been awarded follow-on funding to further commercialise their technology. |
| Year(s) Of Engagement Activity | 2008,2009 |
| Description | U3A Regional Conference (East Midlands July 2011) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | University of the Third Age Regional Conference held at Holywell Park, Loughborough, 22 July 2011 - invited talk entitled "Boning up - exercise for preventing osteoporosis" Approx 200 older people attended talk which prompted questions and discussion. Request made for speaker to present at other local U3A events. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Workshops on exercise and eating disorders |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Health professionals |
| Results and Impact | One-day workshops for clinical psychologists and psychiatrists, and for sports coaches and fitness professionals. Extensive research collaboration formed with Leicester clinicians. Completion of treatment manual and online clinical guidelines. Treatment group now running at Leicester ED Service. £327k research funding secured. Research group is now delivering workshops for coaches based on Loughborough University Campus where a significant number of the UK's elite and developing athletes train. |
| Year(s) Of Engagement Activity | 2007,2008,2009 |
| Description | World Congress (Glasgow 2012) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | World Congress of Active Ageing held in Glasgow, 13-17 August 2012 - invited talk entitled "What do we know about exercise and bone health?" Around 100 people (many practitioners working with older people) attended talk which prompted questions and discussion. Request made to provide further information and copies of slides. |
| Year(s) Of Engagement Activity | 2012 |