UCL: Bridging disciplines in multi-scale, multi-dimensional and time-series biomedical imaging

Lead Research Organisation: University College London
Department Name: Medical Physics and Biomedical Eng

Abstract

Imaging technologies are allowing us to probe the shape and function of the organs and structures that make up the human body. This can be done without harming the patient in any way. These technologies allow us to monitor treatment and guide therapies to where they are most needed. The 3D imaging techniques such as X-ray CT and MRI have only been around for 30 years yet in that time they have transformed healthcare. In recent years there have been significant advances in extending imaging methods, in particular optical techniques, to investigate the function of living cells that make up the human body and the interactions between the molecules that govern the functions of these cells. The level of detail provided by these images covers 6 orders of magnitude, often in 3D. This has created a challenge to find ways to understand how to relate relevant information across this wide range of spatial scale. This is required in order to better understand the function and interactions of the body?s organs, and their constituent cells, together with the molecular interactions that control their function in health and disease. Many of these imaging technologies also provide time varying information so that dynamic processes can be observed and measured. While these ?movies? provide invaluable information on dynamic and time changing processes that are so important in understanding normal metabolic function and disease, their analysis provides particularly difficult computational and mathematical challenges. This programme will bring together some of the world?s leading physical scientists, mathematicians, life scientists and clinicians to exploit these opportunities to establish research programmes to better understand the functioning of the human body in health and disease and ultimately to devise and test new therapies that result from this better understanding.

Technical Summary

In life sciences and medicine many of the most exciting advances and discoveries take place at the boundary of traditional academic disciplines, in particular at the interface with the physical sciences. UCL undertakes world-class research in all three areas and in particular has one of the largest groupings of biomedical research in Europe. Imaging is key to many of the advances in biomedicine and UCL has internationally leading groups in both clinical and biomedical imaging. The overall objective of UCL?s bid to the MRC?s Interdisciplinary Bridging Award scheme is the formation of a programme that brings Physicists, Engineers, Computer Scientists and Mathematicians together with Life Scientists and Clinicians. The aim of this programme is to facilitate and coordinate the significant research opportunities that arise from applying multidimensional and time-series imaging and information processing across a wide range of spatial scales. This activity will also support ongoing interdisciplinary research into developing new MR, optical and ultrasound imaging technologies and the chemistry required to develop new contrast agents and tracers of biological function. This will accelerate our understanding of the basics of life and the biological processes that underlie major health problems such as cancer, neurodegenerative diseases and cardiovascular diseases. The multidisciplinary activity will accelerate the translation of these discoveries to novel therapies and diagnostics in the clinic.

The bridging activities will consist of a seminar programme, one-day workshops and weekly joint seminars of the groups involved. We will establish and maintain a database of research in biomedical imaging. We will fund visits by 5 internationally renowned scientists in areas of relevance to our discipline bridging activity. Another key feature of our proposal is creation of a fund of #130,000 that will be used to facilitate and pump prime research activity between the groups that form the programme.

Publications

10 25 50
publication icon
Silberberg YR (2008) Mitochondrial displacements in response to nanomechanical forces. in Journal of molecular recognition : JMR

 
Description MRC Neuroimaging review
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description NCRI review of PET imaging
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description CRUK Comprehensive Cancer Imaging Centre
Amount £5,000,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description EPSRC EP/F025750/1 Transcostal High Intensity Focussed Ultrasound
Amount £1,517,247 (GBP)
Funding ID EP/F025750/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start  
 
Description UCL Imaging Technology Platform 
Organisation Great Ormond Street Hospital (GOSH)
Country United Kingdom 
Sector Hospitals 
PI Contribution Setting up these multidisciplinary collaborations using teh IDBA funds has been a major activity at CMIC and CABI over the last 3 years and will be reported more fully with the final report due at the end of January.
Collaborator Contribution Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically in MRI we have obtianed funds for a whole body 3T for research in neonatal brain injury with grant applications under review.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Spoecifcally the IDBA grant has facilitated links with the newly formed Centre for Advanced Biomedical Imaging, the preclinical imaging group at UCL and part of the Department of Medicine. This has spawned a number of collaborative projects in the areas of MR contrast agents, combined in-vivo confocal microscopy and MRI.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically we have built a significant collaboration with the Dementia Research Centre in teh area of imaging in assessment of progression in neurodegenerative diseases.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. This collaboration is only just starting but interesting opportunities in ovarian cancer are emergingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically collaborative work on the human visual system was partly instigated by the MRC IDBA award.We have a substantial programme in image guided focal ablation of prostate cancer and work is starting on image guided liver cancer treatment, inconjunction with the Department of Mechanical Engineering.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically MRI activity in developing fast cardiac imaging methods for assessing cardiac function.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. A significant number of productive links have been established including the activity of the EPSRC/CRUK CCIC and most recently the successful bid for the TACE2 clinical trial in liver cancer.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. WOrking together on image registration, motion correction and image reconstruction. Have attracted EPSRC funding.Significant collaboration in high intensity focussed ultrasound and image guided liver cancer treatment - EPSRC funded. Developing work in lung airway modelling and microbubbles as contrast agents and drug delivery agents.The MRC IDBA was set up with Justin Molloy at Mill Hill and this enabled discussion on strategy that in turn has fed into the development of plans regarding the UKCMRI
Impact This initiative has been primarily about setting up collaborations. There have been notable research outputs resulting from these collaborations but these have been reported by the primary funder of each programme and project and therefore (I presume) cannot be reported here.
Start Year 2006
 
Description UCL Imaging Technology Platform 
Organisation Medical Research Council (MRC)
Department MRC National Institute for Medical Research (NIMR)
Country United Kingdom 
Sector Academic/University 
PI Contribution Setting up these multidisciplinary collaborations using teh IDBA funds has been a major activity at CMIC and CABI over the last 3 years and will be reported more fully with the final report due at the end of January.
Collaborator Contribution Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically in MRI we have obtianed funds for a whole body 3T for research in neonatal brain injury with grant applications under review.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Spoecifcally the IDBA grant has facilitated links with the newly formed Centre for Advanced Biomedical Imaging, the preclinical imaging group at UCL and part of the Department of Medicine. This has spawned a number of collaborative projects in the areas of MR contrast agents, combined in-vivo confocal microscopy and MRI.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically we have built a significant collaboration with the Dementia Research Centre in teh area of imaging in assessment of progression in neurodegenerative diseases.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. This collaboration is only just starting but interesting opportunities in ovarian cancer are emergingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically collaborative work on the human visual system was partly instigated by the MRC IDBA award.We have a substantial programme in image guided focal ablation of prostate cancer and work is starting on image guided liver cancer treatment, inconjunction with the Department of Mechanical Engineering.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically MRI activity in developing fast cardiac imaging methods for assessing cardiac function.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. A significant number of productive links have been established including the activity of the EPSRC/CRUK CCIC and most recently the successful bid for the TACE2 clinical trial in liver cancer.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. WOrking together on image registration, motion correction and image reconstruction. Have attracted EPSRC funding.Significant collaboration in high intensity focussed ultrasound and image guided liver cancer treatment - EPSRC funded. Developing work in lung airway modelling and microbubbles as contrast agents and drug delivery agents.The MRC IDBA was set up with Justin Molloy at Mill Hill and this enabled discussion on strategy that in turn has fed into the development of plans regarding the UKCMRI
Impact This initiative has been primarily about setting up collaborations. There have been notable research outputs resulting from these collaborations but these have been reported by the primary funder of each programme and project and therefore (I presume) cannot be reported here.
Start Year 2006
 
Description UCL Imaging Technology Platform 
Organisation University College London
Department Biosciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Setting up these multidisciplinary collaborations using teh IDBA funds has been a major activity at CMIC and CABI over the last 3 years and will be reported more fully with the final report due at the end of January.
Collaborator Contribution Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically in MRI we have obtianed funds for a whole body 3T for research in neonatal brain injury with grant applications under review.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Spoecifcally the IDBA grant has facilitated links with the newly formed Centre for Advanced Biomedical Imaging, the preclinical imaging group at UCL and part of the Department of Medicine. This has spawned a number of collaborative projects in the areas of MR contrast agents, combined in-vivo confocal microscopy and MRI.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically we have built a significant collaboration with the Dementia Research Centre in teh area of imaging in assessment of progression in neurodegenerative diseases.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. This collaboration is only just starting but interesting opportunities in ovarian cancer are emergingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically collaborative work on the human visual system was partly instigated by the MRC IDBA award.We have a substantial programme in image guided focal ablation of prostate cancer and work is starting on image guided liver cancer treatment, inconjunction with the Department of Mechanical Engineering.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically MRI activity in developing fast cardiac imaging methods for assessing cardiac function.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. A significant number of productive links have been established including the activity of the EPSRC/CRUK CCIC and most recently the successful bid for the TACE2 clinical trial in liver cancer.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. WOrking together on image registration, motion correction and image reconstruction. Have attracted EPSRC funding.Significant collaboration in high intensity focussed ultrasound and image guided liver cancer treatment - EPSRC funded. Developing work in lung airway modelling and microbubbles as contrast agents and drug delivery agents.The MRC IDBA was set up with Justin Molloy at Mill Hill and this enabled discussion on strategy that in turn has fed into the development of plans regarding the UKCMRI
Impact This initiative has been primarily about setting up collaborations. There have been notable research outputs resulting from these collaborations but these have been reported by the primary funder of each programme and project and therefore (I presume) cannot be reported here.
Start Year 2006
 
Description UCL Imaging Technology Platform 
Organisation University College London
Department Biosciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Setting up these multidisciplinary collaborations using teh IDBA funds has been a major activity at CMIC and CABI over the last 3 years and will be reported more fully with the final report due at the end of January.
Collaborator Contribution Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically in MRI we have obtianed funds for a whole body 3T for research in neonatal brain injury with grant applications under review.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Spoecifcally the IDBA grant has facilitated links with the newly formed Centre for Advanced Biomedical Imaging, the preclinical imaging group at UCL and part of the Department of Medicine. This has spawned a number of collaborative projects in the areas of MR contrast agents, combined in-vivo confocal microscopy and MRI.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically we have built a significant collaboration with the Dementia Research Centre in teh area of imaging in assessment of progression in neurodegenerative diseases.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. This collaboration is only just starting but interesting opportunities in ovarian cancer are emergingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically collaborative work on the human visual system was partly instigated by the MRC IDBA award.We have a substantial programme in image guided focal ablation of prostate cancer and work is starting on image guided liver cancer treatment, inconjunction with the Department of Mechanical Engineering.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically MRI activity in developing fast cardiac imaging methods for assessing cardiac function.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. A significant number of productive links have been established including the activity of the EPSRC/CRUK CCIC and most recently the successful bid for the TACE2 clinical trial in liver cancer.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. WOrking together on image registration, motion correction and image reconstruction. Have attracted EPSRC funding.Significant collaboration in high intensity focussed ultrasound and image guided liver cancer treatment - EPSRC funded. Developing work in lung airway modelling and microbubbles as contrast agents and drug delivery agents.The MRC IDBA was set up with Justin Molloy at Mill Hill and this enabled discussion on strategy that in turn has fed into the development of plans regarding the UKCMRI
Impact This initiative has been primarily about setting up collaborations. There have been notable research outputs resulting from these collaborations but these have been reported by the primary funder of each programme and project and therefore (I presume) cannot be reported here.
Start Year 2006
 
Description UCL Imaging Technology Platform 
Organisation University College London
Department Centre for Gastroenterology and Nutrition
Country United Kingdom 
Sector Academic/University 
PI Contribution Setting up these multidisciplinary collaborations using teh IDBA funds has been a major activity at CMIC and CABI over the last 3 years and will be reported more fully with the final report due at the end of January.
Collaborator Contribution Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically in MRI we have obtianed funds for a whole body 3T for research in neonatal brain injury with grant applications under review.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Spoecifcally the IDBA grant has facilitated links with the newly formed Centre for Advanced Biomedical Imaging, the preclinical imaging group at UCL and part of the Department of Medicine. This has spawned a number of collaborative projects in the areas of MR contrast agents, combined in-vivo confocal microscopy and MRI.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically we have built a significant collaboration with the Dementia Research Centre in teh area of imaging in assessment of progression in neurodegenerative diseases.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. This collaboration is only just starting but interesting opportunities in ovarian cancer are emergingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically collaborative work on the human visual system was partly instigated by the MRC IDBA award.We have a substantial programme in image guided focal ablation of prostate cancer and work is starting on image guided liver cancer treatment, inconjunction with the Department of Mechanical Engineering.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically MRI activity in developing fast cardiac imaging methods for assessing cardiac function.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. A significant number of productive links have been established including the activity of the EPSRC/CRUK CCIC and most recently the successful bid for the TACE2 clinical trial in liver cancer.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. WOrking together on image registration, motion correction and image reconstruction. Have attracted EPSRC funding.Significant collaboration in high intensity focussed ultrasound and image guided liver cancer treatment - EPSRC funded. Developing work in lung airway modelling and microbubbles as contrast agents and drug delivery agents.The MRC IDBA was set up with Justin Molloy at Mill Hill and this enabled discussion on strategy that in turn has fed into the development of plans regarding the UKCMRI
Impact This initiative has been primarily about setting up collaborations. There have been notable research outputs resulting from these collaborations but these have been reported by the primary funder of each programme and project and therefore (I presume) cannot be reported here.
Start Year 2006
 
Description UCL Imaging Technology Platform 
Organisation University College London
Department Division of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Setting up these multidisciplinary collaborations using teh IDBA funds has been a major activity at CMIC and CABI over the last 3 years and will be reported more fully with the final report due at the end of January.
Collaborator Contribution Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically in MRI we have obtianed funds for a whole body 3T for research in neonatal brain injury with grant applications under review.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Spoecifcally the IDBA grant has facilitated links with the newly formed Centre for Advanced Biomedical Imaging, the preclinical imaging group at UCL and part of the Department of Medicine. This has spawned a number of collaborative projects in the areas of MR contrast agents, combined in-vivo confocal microscopy and MRI.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically we have built a significant collaboration with the Dementia Research Centre in teh area of imaging in assessment of progression in neurodegenerative diseases.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. This collaboration is only just starting but interesting opportunities in ovarian cancer are emergingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically collaborative work on the human visual system was partly instigated by the MRC IDBA award.We have a substantial programme in image guided focal ablation of prostate cancer and work is starting on image guided liver cancer treatment, inconjunction with the Department of Mechanical Engineering.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically MRI activity in developing fast cardiac imaging methods for assessing cardiac function.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. A significant number of productive links have been established including the activity of the EPSRC/CRUK CCIC and most recently the successful bid for the TACE2 clinical trial in liver cancer.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. WOrking together on image registration, motion correction and image reconstruction. Have attracted EPSRC funding.Significant collaboration in high intensity focussed ultrasound and image guided liver cancer treatment - EPSRC funded. Developing work in lung airway modelling and microbubbles as contrast agents and drug delivery agents.The MRC IDBA was set up with Justin Molloy at Mill Hill and this enabled discussion on strategy that in turn has fed into the development of plans regarding the UKCMRI
Impact This initiative has been primarily about setting up collaborations. There have been notable research outputs resulting from these collaborations but these have been reported by the primary funder of each programme and project and therefore (I presume) cannot be reported here.
Start Year 2006
 
Description UCL Imaging Technology Platform 
Organisation University College London
Department Division of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Setting up these multidisciplinary collaborations using teh IDBA funds has been a major activity at CMIC and CABI over the last 3 years and will be reported more fully with the final report due at the end of January.
Collaborator Contribution Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically in MRI we have obtianed funds for a whole body 3T for research in neonatal brain injury with grant applications under review.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Spoecifcally the IDBA grant has facilitated links with the newly formed Centre for Advanced Biomedical Imaging, the preclinical imaging group at UCL and part of the Department of Medicine. This has spawned a number of collaborative projects in the areas of MR contrast agents, combined in-vivo confocal microscopy and MRI.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically we have built a significant collaboration with the Dementia Research Centre in teh area of imaging in assessment of progression in neurodegenerative diseases.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. This collaboration is only just starting but interesting opportunities in ovarian cancer are emergingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically collaborative work on the human visual system was partly instigated by the MRC IDBA award.We have a substantial programme in image guided focal ablation of prostate cancer and work is starting on image guided liver cancer treatment, inconjunction with the Department of Mechanical Engineering.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically MRI activity in developing fast cardiac imaging methods for assessing cardiac function.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. A significant number of productive links have been established including the activity of the EPSRC/CRUK CCIC and most recently the successful bid for the TACE2 clinical trial in liver cancer.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. WOrking together on image registration, motion correction and image reconstruction. Have attracted EPSRC funding.Significant collaboration in high intensity focussed ultrasound and image guided liver cancer treatment - EPSRC funded. Developing work in lung airway modelling and microbubbles as contrast agents and drug delivery agents.The MRC IDBA was set up with Justin Molloy at Mill Hill and this enabled discussion on strategy that in turn has fed into the development of plans regarding the UKCMRI
Impact This initiative has been primarily about setting up collaborations. There have been notable research outputs resulting from these collaborations but these have been reported by the primary funder of each programme and project and therefore (I presume) cannot be reported here.
Start Year 2006
 
Description UCL Imaging Technology Platform 
Organisation University College London
Department Division of Psychology & Language Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Setting up these multidisciplinary collaborations using teh IDBA funds has been a major activity at CMIC and CABI over the last 3 years and will be reported more fully with the final report due at the end of January.
Collaborator Contribution Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically in MRI we have obtianed funds for a whole body 3T for research in neonatal brain injury with grant applications under review.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Spoecifcally the IDBA grant has facilitated links with the newly formed Centre for Advanced Biomedical Imaging, the preclinical imaging group at UCL and part of the Department of Medicine. This has spawned a number of collaborative projects in the areas of MR contrast agents, combined in-vivo confocal microscopy and MRI.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically we have built a significant collaboration with the Dementia Research Centre in teh area of imaging in assessment of progression in neurodegenerative diseases.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. This collaboration is only just starting but interesting opportunities in ovarian cancer are emergingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically collaborative work on the human visual system was partly instigated by the MRC IDBA award.We have a substantial programme in image guided focal ablation of prostate cancer and work is starting on image guided liver cancer treatment, inconjunction with the Department of Mechanical Engineering.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically MRI activity in developing fast cardiac imaging methods for assessing cardiac function.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. A significant number of productive links have been established including the activity of the EPSRC/CRUK CCIC and most recently the successful bid for the TACE2 clinical trial in liver cancer.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. WOrking together on image registration, motion correction and image reconstruction. Have attracted EPSRC funding.Significant collaboration in high intensity focussed ultrasound and image guided liver cancer treatment - EPSRC funded. Developing work in lung airway modelling and microbubbles as contrast agents and drug delivery agents.The MRC IDBA was set up with Justin Molloy at Mill Hill and this enabled discussion on strategy that in turn has fed into the development of plans regarding the UKCMRI
Impact This initiative has been primarily about setting up collaborations. There have been notable research outputs resulting from these collaborations but these have been reported by the primary funder of each programme and project and therefore (I presume) cannot be reported here.
Start Year 2006
 
Description UCL Imaging Technology Platform 
Organisation University College London
Department Division of Surgery & Interventional Science
Country United Kingdom 
Sector Academic/University 
PI Contribution Setting up these multidisciplinary collaborations using teh IDBA funds has been a major activity at CMIC and CABI over the last 3 years and will be reported more fully with the final report due at the end of January.
Collaborator Contribution Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically in MRI we have obtianed funds for a whole body 3T for research in neonatal brain injury with grant applications under review.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Spoecifcally the IDBA grant has facilitated links with the newly formed Centre for Advanced Biomedical Imaging, the preclinical imaging group at UCL and part of the Department of Medicine. This has spawned a number of collaborative projects in the areas of MR contrast agents, combined in-vivo confocal microscopy and MRI.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically we have built a significant collaboration with the Dementia Research Centre in teh area of imaging in assessment of progression in neurodegenerative diseases.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. This collaboration is only just starting but interesting opportunities in ovarian cancer are emergingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically collaborative work on the human visual system was partly instigated by the MRC IDBA award.We have a substantial programme in image guided focal ablation of prostate cancer and work is starting on image guided liver cancer treatment, inconjunction with the Department of Mechanical Engineering.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically MRI activity in developing fast cardiac imaging methods for assessing cardiac function.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. A significant number of productive links have been established including the activity of the EPSRC/CRUK CCIC and most recently the successful bid for the TACE2 clinical trial in liver cancer.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. WOrking together on image registration, motion correction and image reconstruction. Have attracted EPSRC funding.Significant collaboration in high intensity focussed ultrasound and image guided liver cancer treatment - EPSRC funded. Developing work in lung airway modelling and microbubbles as contrast agents and drug delivery agents.The MRC IDBA was set up with Justin Molloy at Mill Hill and this enabled discussion on strategy that in turn has fed into the development of plans regarding the UKCMRI
Impact This initiative has been primarily about setting up collaborations. There have been notable research outputs resulting from these collaborations but these have been reported by the primary funder of each programme and project and therefore (I presume) cannot be reported here.
Start Year 2006
 
Description UCL Imaging Technology Platform 
Organisation University College London
Department Institute of Child Health
Country United Kingdom 
Sector Academic/University 
PI Contribution Setting up these multidisciplinary collaborations using teh IDBA funds has been a major activity at CMIC and CABI over the last 3 years and will be reported more fully with the final report due at the end of January.
Collaborator Contribution Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically in MRI we have obtianed funds for a whole body 3T for research in neonatal brain injury with grant applications under review.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Spoecifcally the IDBA grant has facilitated links with the newly formed Centre for Advanced Biomedical Imaging, the preclinical imaging group at UCL and part of the Department of Medicine. This has spawned a number of collaborative projects in the areas of MR contrast agents, combined in-vivo confocal microscopy and MRI.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically we have built a significant collaboration with the Dementia Research Centre in teh area of imaging in assessment of progression in neurodegenerative diseases.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. This collaboration is only just starting but interesting opportunities in ovarian cancer are emergingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically collaborative work on the human visual system was partly instigated by the MRC IDBA award.We have a substantial programme in image guided focal ablation of prostate cancer and work is starting on image guided liver cancer treatment, inconjunction with the Department of Mechanical Engineering.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically MRI activity in developing fast cardiac imaging methods for assessing cardiac function.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. A significant number of productive links have been established including the activity of the EPSRC/CRUK CCIC and most recently the successful bid for the TACE2 clinical trial in liver cancer.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. WOrking together on image registration, motion correction and image reconstruction. Have attracted EPSRC funding.Significant collaboration in high intensity focussed ultrasound and image guided liver cancer treatment - EPSRC funded. Developing work in lung airway modelling and microbubbles as contrast agents and drug delivery agents.The MRC IDBA was set up with Justin Molloy at Mill Hill and this enabled discussion on strategy that in turn has fed into the development of plans regarding the UKCMRI
Impact This initiative has been primarily about setting up collaborations. There have been notable research outputs resulting from these collaborations but these have been reported by the primary funder of each programme and project and therefore (I presume) cannot be reported here.
Start Year 2006
 
Description UCL Imaging Technology Platform 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution Setting up these multidisciplinary collaborations using teh IDBA funds has been a major activity at CMIC and CABI over the last 3 years and will be reported more fully with the final report due at the end of January.
Collaborator Contribution Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically in MRI we have obtianed funds for a whole body 3T for research in neonatal brain injury with grant applications under review.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Spoecifcally the IDBA grant has facilitated links with the newly formed Centre for Advanced Biomedical Imaging, the preclinical imaging group at UCL and part of the Department of Medicine. This has spawned a number of collaborative projects in the areas of MR contrast agents, combined in-vivo confocal microscopy and MRI.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically we have built a significant collaboration with the Dementia Research Centre in teh area of imaging in assessment of progression in neurodegenerative diseases.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. This collaboration is only just starting but interesting opportunities in ovarian cancer are emergingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically collaborative work on the human visual system was partly instigated by the MRC IDBA award.We have a substantial programme in image guided focal ablation of prostate cancer and work is starting on image guided liver cancer treatment, inconjunction with the Department of Mechanical Engineering.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically MRI activity in developing fast cardiac imaging methods for assessing cardiac function.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. A significant number of productive links have been established including the activity of the EPSRC/CRUK CCIC and most recently the successful bid for the TACE2 clinical trial in liver cancer.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. WOrking together on image registration, motion correction and image reconstruction. Have attracted EPSRC funding.Significant collaboration in high intensity focussed ultrasound and image guided liver cancer treatment - EPSRC funded. Developing work in lung airway modelling and microbubbles as contrast agents and drug delivery agents.The MRC IDBA was set up with Justin Molloy at Mill Hill and this enabled discussion on strategy that in turn has fed into the development of plans regarding the UKCMRI
Impact This initiative has been primarily about setting up collaborations. There have been notable research outputs resulting from these collaborations but these have been reported by the primary funder of each programme and project and therefore (I presume) cannot be reported here.
Start Year 2006
 
Description UCL Imaging Technology Platform 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution Setting up these multidisciplinary collaborations using teh IDBA funds has been a major activity at CMIC and CABI over the last 3 years and will be reported more fully with the final report due at the end of January.
Collaborator Contribution Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically in MRI we have obtianed funds for a whole body 3T for research in neonatal brain injury with grant applications under review.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Spoecifcally the IDBA grant has facilitated links with the newly formed Centre for Advanced Biomedical Imaging, the preclinical imaging group at UCL and part of the Department of Medicine. This has spawned a number of collaborative projects in the areas of MR contrast agents, combined in-vivo confocal microscopy and MRI.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically we have built a significant collaboration with the Dementia Research Centre in teh area of imaging in assessment of progression in neurodegenerative diseases.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. This collaboration is only just starting but interesting opportunities in ovarian cancer are emergingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically collaborative work on the human visual system was partly instigated by the MRC IDBA award.We have a substantial programme in image guided focal ablation of prostate cancer and work is starting on image guided liver cancer treatment, inconjunction with the Department of Mechanical Engineering.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically MRI activity in developing fast cardiac imaging methods for assessing cardiac function.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. A significant number of productive links have been established including the activity of the EPSRC/CRUK CCIC and most recently the successful bid for the TACE2 clinical trial in liver cancer.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. WOrking together on image registration, motion correction and image reconstruction. Have attracted EPSRC funding.Significant collaboration in high intensity focussed ultrasound and image guided liver cancer treatment - EPSRC funded. Developing work in lung airway modelling and microbubbles as contrast agents and drug delivery agents.The MRC IDBA was set up with Justin Molloy at Mill Hill and this enabled discussion on strategy that in turn has fed into the development of plans regarding the UKCMRI
Impact This initiative has been primarily about setting up collaborations. There have been notable research outputs resulting from these collaborations but these have been reported by the primary funder of each programme and project and therefore (I presume) cannot be reported here.
Start Year 2006
 
Description UCL Imaging Technology Platform 
Organisation University College London
Department Mechanical Engineering
Country United Kingdom 
Sector Academic/University 
PI Contribution Setting up these multidisciplinary collaborations using teh IDBA funds has been a major activity at CMIC and CABI over the last 3 years and will be reported more fully with the final report due at the end of January.
Collaborator Contribution Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically in MRI we have obtianed funds for a whole body 3T for research in neonatal brain injury with grant applications under review.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Spoecifcally the IDBA grant has facilitated links with the newly formed Centre for Advanced Biomedical Imaging, the preclinical imaging group at UCL and part of the Department of Medicine. This has spawned a number of collaborative projects in the areas of MR contrast agents, combined in-vivo confocal microscopy and MRI.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically we have built a significant collaboration with the Dementia Research Centre in teh area of imaging in assessment of progression in neurodegenerative diseases.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. This collaboration is only just starting but interesting opportunities in ovarian cancer are emergingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically collaborative work on the human visual system was partly instigated by the MRC IDBA award.We have a substantial programme in image guided focal ablation of prostate cancer and work is starting on image guided liver cancer treatment, inconjunction with the Department of Mechanical Engineering.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically MRI activity in developing fast cardiac imaging methods for assessing cardiac function.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. A significant number of productive links have been established including the activity of the EPSRC/CRUK CCIC and most recently the successful bid for the TACE2 clinical trial in liver cancer.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. WOrking together on image registration, motion correction and image reconstruction. Have attracted EPSRC funding.Significant collaboration in high intensity focussed ultrasound and image guided liver cancer treatment - EPSRC funded. Developing work in lung airway modelling and microbubbles as contrast agents and drug delivery agents.The MRC IDBA was set up with Justin Molloy at Mill Hill and this enabled discussion on strategy that in turn has fed into the development of plans regarding the UKCMRI
Impact This initiative has been primarily about setting up collaborations. There have been notable research outputs resulting from these collaborations but these have been reported by the primary funder of each programme and project and therefore (I presume) cannot be reported here.
Start Year 2006
 
Description UCL Imaging Technology Platform 
Organisation University College London
Department UCL Cancer Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Setting up these multidisciplinary collaborations using teh IDBA funds has been a major activity at CMIC and CABI over the last 3 years and will be reported more fully with the final report due at the end of January.
Collaborator Contribution Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically in MRI we have obtianed funds for a whole body 3T for research in neonatal brain injury with grant applications under review.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Spoecifcally the IDBA grant has facilitated links with the newly formed Centre for Advanced Biomedical Imaging, the preclinical imaging group at UCL and part of the Department of Medicine. This has spawned a number of collaborative projects in the areas of MR contrast agents, combined in-vivo confocal microscopy and MRI.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically we have built a significant collaboration with the Dementia Research Centre in teh area of imaging in assessment of progression in neurodegenerative diseases.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. This collaboration is only just starting but interesting opportunities in ovarian cancer are emergingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically collaborative work on the human visual system was partly instigated by the MRC IDBA award.We have a substantial programme in image guided focal ablation of prostate cancer and work is starting on image guided liver cancer treatment, inconjunction with the Department of Mechanical Engineering.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically MRI activity in developing fast cardiac imaging methods for assessing cardiac function.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. A significant number of productive links have been established including the activity of the EPSRC/CRUK CCIC and most recently the successful bid for the TACE2 clinical trial in liver cancer.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. WOrking together on image registration, motion correction and image reconstruction. Have attracted EPSRC funding.Significant collaboration in high intensity focussed ultrasound and image guided liver cancer treatment - EPSRC funded. Developing work in lung airway modelling and microbubbles as contrast agents and drug delivery agents.The MRC IDBA was set up with Justin Molloy at Mill Hill and this enabled discussion on strategy that in turn has fed into the development of plans regarding the UKCMRI
Impact This initiative has been primarily about setting up collaborations. There have been notable research outputs resulting from these collaborations but these have been reported by the primary funder of each programme and project and therefore (I presume) cannot be reported here.
Start Year 2006
 
Description UCL Imaging Technology Platform 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Setting up these multidisciplinary collaborations using teh IDBA funds has been a major activity at CMIC and CABI over the last 3 years and will be reported more fully with the final report due at the end of January.
Collaborator Contribution Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically in MRI we have obtianed funds for a whole body 3T for research in neonatal brain injury with grant applications under review.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imagingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Spoecifcally the IDBA grant has facilitated links with the newly formed Centre for Advanced Biomedical Imaging, the preclinical imaging group at UCL and part of the Department of Medicine. This has spawned a number of collaborative projects in the areas of MR contrast agents, combined in-vivo confocal microscopy and MRI.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically we have built a significant collaboration with the Dementia Research Centre in teh area of imaging in assessment of progression in neurodegenerative diseases.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. This collaboration is only just starting but interesting opportunities in ovarian cancer are emergingBringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically collaborative work on the human visual system was partly instigated by the MRC IDBA award.We have a substantial programme in image guided focal ablation of prostate cancer and work is starting on image guided liver cancer treatment, inconjunction with the Department of Mechanical Engineering.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. Specifically MRI activity in developing fast cardiac imaging methods for assessing cardiac function.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. A significant number of productive links have been established including the activity of the EPSRC/CRUK CCIC and most recently the successful bid for the TACE2 clinical trial in liver cancer.Bringing together of the imaging activity at UCL from microscopy to preclinical to clinical imaging. WOrking together on image registration, motion correction and image reconstruction. Have attracted EPSRC funding.Significant collaboration in high intensity focussed ultrasound and image guided liver cancer treatment - EPSRC funded. Developing work in lung airway modelling and microbubbles as contrast agents and drug delivery agents.The MRC IDBA was set up with Justin Molloy at Mill Hill and this enabled discussion on strategy that in turn has fed into the development of plans regarding the UKCMRI
Impact This initiative has been primarily about setting up collaborations. There have been notable research outputs resulting from these collaborations but these have been reported by the primary funder of each programme and project and therefore (I presume) cannot be reported here.
Start Year 2006