MRC Centre for Translational Research in Obesity and related Metabolic Diseases

Lead Research Organisation: University of Cambridge
Department Name: Clinical Biochemist

Abstract

Obesity is a major cause of premature death and disability. Obesity is particularly closely linked to the development of diabetes, with its attendant risks of blindness, kidney failure and amputation. These diseases are becoming more common. They both result from a combination of lifestyle factors and genetic susceptibility. Now that we are beginning to make strides in understanding the nature of these genetic and lifestyle factors, we need to better understand exactly how they interact to result in disease. When we do so, we will be in a much better position to target our attempts at prevention and treatment in the right way to the right individuals.

This application comes from a group of scientists, some based in basic science laboratories, some working with patients, yet others working in the area of public health. We want to bring our individual skills and knowledge together to create a Centre for research in obesity and diabetes that is greater than the sum of its parts. Through charitable and other sources we have already raised #20M for a new building in Cambridge to act as the hub for this Centre and are now looking to the MRC to help us to provide the core research facilities (including equipment and specialised technical staff) required for our studies. The MRC funding would also enable us to increase the number of students we train in this important but relatively neglected area.

Technical Summary

Obesity is a major threat to public health in the UK and internationally. The clearest impact of obesity on health is through its influence on insulin resistance,diabetes and dyslipidaemia. Improved understanding of the fundamental causes of obesity and how it impacts on insuln resistance, diabetes and vascular risk will be critically important to the design of effective strategies for treatment and prevention.

We propose the establishment of a new MRC Centre for Translational Research in Obesity and Related Metabolic Disease (MRC CTROM) which exploits the existing collaborative interactions between internationally renowned clinical and basic scientists at the University of Cambridge, relevant MRC Units within the Cambridge area, the Wellcome Trust Sanger Institute and Oxford University. We believe that the collective expertise and reputation of this group of investigators will provide a unique intellectual synergy with the capability of becoming a world-leading centre for translational research in this crucially important area of biomedical research.

Organisations

Publications

10 25 50
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Acharjee A (2017) The translation of lipid profiles to nutritional biomarkers in the study of infant metabolism. in Metabolomics : Official journal of the Metabolomic Society

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Aiken CE (2013) Sex differences in developmental programming models. in Reproduction (Cambridge, England)

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Aiken CE (2014) Transgenerational developmental programming. in Human reproduction update

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Aiken CE (2013) Suboptimal nutrition in utero causes DNA damage and accelerated aging of the female reproductive tract. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology

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Alfaradhi MZ (2014) Oxidative stress and altered lipid homeostasis in the programming of offspring fatty liver by maternal obesity. in American journal of physiology. Regulatory, integrative and comparative physiology

 
Description BBSRC - project grant
Amount £513,407 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2009 
End 09/2012
 
Description BBSRC/DRINC Diet and Health Research Industry Club
Amount £549,226 (GBP)
Funding ID BB/MO27252/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2015 
End 10/2019
 
Description BHF (AdDIT)
Amount £1,268,755 (GBP)
Funding ID SP/071002/23394 07CC14 RPAG/065 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2008 
End 03/2017
 
Description BHF - project grant
Amount £145,520 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2008 
End 12/2009
 
Description BRC NIHR Biomedical Research Centre
Amount £750,810 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2012 
End 03/2017
 
Description British Council - exchange award
Amount £4,617 (GBP)
Organisation British Council 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2009 
End 12/2009
 
Description DUK (AdDIT)
Amount £1,260,132 (GBP)
Funding ID BDA:RD06/003341 
Organisation Diabetes UK 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2007 
End 10/2017
 
Description Diabetes UK
Amount £1,260,132 (GBP)
Funding ID RG66036 
Organisation Diabetes UK 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2007 
End 05/2016
 
Description Diabetes UK Extension -AdDIT
Amount £469,281 (GBP)
Funding ID 12/0004468 
Organisation Diabetes UK 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2012 
End 08/2016
 
Description EC FP6 - collaborative award
Amount £45,500 (GBP)
Organisation Sixth Framework Programme (FP6) 
Sector Public
Country European Union (EU)
Start 09/2007 
End 09/2009
 
Description EU FP7 - COLLABORATIVE AWARD EUROCHIP
Amount £437,332 (GBP)
Funding ID 241592 
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 10/2009 
End 09/2013
 
Description EU FP7 - collaborative award
Amount £599,000 (GBP)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start  
 
Description EU FP7 - collaborative award
Amount £490,606 (GBP)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 10/2008 
End 09/2012
 
Description EU FP7 - collaborative award
Amount £78,277 (GBP)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 04/2010 
End 03/2011
 
Description EU FP7 - collaborative award, MITIN
Amount £347,129 (GBP)
Funding ID 223450 
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 11/2008 
End 10/2011
 
Description FP7 Health.2012.2.4.4-1
Amount € 2,696,648 (EUR)
Funding ID PREVENTROP305485 RPAG/110 
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 03/2013 
End 02/2018
 
Description GSK - collaborative grant
Amount £41,533 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 01/2008 
End 12/2010
 
Description Gates Foundation
Amount $623,000 (USD)
Funding ID RG 67603 
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 01/2013 
End 12/2016
 
Description Grant for Growth Innovation (Merck) Effect of insulin sensitisation on Insulin-Like Growth Factor-1 in response to Growth Hormone treatment in children born small for gestational age.
Amount € 200,000 (EUR)
Organisation Merck 
Department Merck UK
Sector Private
Country United Kingdom
Start 01/2016 
End 12/2018
 
Description Greater Glasgow Health Board
Amount £5,000 (GBP)
Funding ID GN10KH234 rg64806 
Organisation NHS Greater Glasgow and Clyde (NHSGGC) 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2011 
End 08/2016
 
Description IMI2 H2020-JTI-IM 12-2014-01-01
Amount € 2,930,000 (EUR)
Funding ID 115797 
Organisation European Commission 
Department Innovative Medicines Initiative (IMI)
Sector Multiple
Country European Union (EU)
Start 11/2015 
End 10/2022
 
Description INTERBIO subcontract
Amount $500,000 (USD)
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 09/2012 
End 08/2014
 
Description Infancy lipidoemic profiles, breast milk fat intake and infancy growth in collaboration with Cambridge-Africa growth cohorts
Amount £7,250 (GBP)
Organisation Alborada Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2014 
End 09/2015
 
Description JDRF
Amount $142,000 (USD)
Funding ID 3-SRA-2016-332-M-R 
Organisation Juvenile Diabetes Research Foundation (JDRF) 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2015 
End 09/2018
 
Description JDRF (AdDIT)
Amount $4,995,843 (USD)
Funding ID Ref 08-2007-902 
Organisation Juvenile Diabetes Research Foundation (JDRF) 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2007 
End 08/2017
 
Description JDRF Overnight closed loop in sub-optimally controlled type 1 diabetes under free living conditions (APCam11)
Amount $1,187,530 (USD)
Funding ID 2-SRA-2014-256-M-R 
Organisation Juvenile Diabetes Research Foundation (JDRF) 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2014 
End 08/2016
 
Description JDRF Validation of novel and candidate biomarkers for diabetic kidney disease in large cohorts of people with type 1 diabetes
Amount $1,995,784 (USD)
Funding ID 2-SRA-2014-277-m-r 
Organisation Juvenile Diabetes Research Foundation (JDRF) 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2014 
End 09/2017
 
Description JPI-HDHL Biomarkers (Joint Programme Initiataive - Healthy Diet Healthy Lifestyle)
Amount € 1,034,440 (EUR)
Funding ID BB/PO28195/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 03/2017 
End 03/2020
 
Description Juvenile Diabetes Research Foundation
Amount $4,995,843 (USD)
Funding ID RG49109 AdDIT 
Organisation Juvenile Diabetes Research Foundation (JDRF) 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2007 
End 08/2016
 
Description MRC - translational research initiative
Amount £665,546 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2008 
End 02/2010
 
Description Medical Research Council
Amount £661,216 (GBP)
Funding ID G0800661 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2009 
End 04/2014
 
Description Medical Research Council (MRC)
Amount £150,000 (GBP)
Funding ID MR/P021174/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Medical Research Council/Training Fellowship (PP)
Amount £193,037 (GBP)
Funding ID G1001995 ID:98634 RG61566 
Organisation Medical Research Council (MRC) 
Department MRC National Institute for Medical Research (NIMR)
Sector Public
Country United Kingdom
Start 04/2007 
End 03/2014
 
Description NIHR EME
Amount £677,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 10/2013 
End 09/2016
 
Description NIHR Type 2 diabetes in childhood building a platform to support novel intervention strategies
Amount £199,885 (GBP)
Organisation University of Birmingham 
Sector Academic/University
Country United Kingdom
Start 04/2013 
End 03/2017
 
Description Research Grant
Amount £121,153 (GBP)
Funding ID 11/0004241 
Organisation Diabetes UK 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2011 
End 11/2013
 
Description The European Federation of Pharmaceutical Industries and Associations/Research Project: SUMMiT
Amount € 235,000 (EUR)
Funding ID 115006/999977172 
Organisation European Federation of Pharmaceutical Industries and Associations (EFPIA) 
Sector Private
Country Belgium
Start 11/2009 
End 10/2014
 
Description Thomas Watt Eden Paediatric Fellowship (Dr Philippa Prentice)
Amount £9,700 (GBP)
Organisation Royal College of Physicians of London 
Department Thomas Watts Eden Fellowship
Sector Learned Society
Country United Kingdom
Start 03/2015 
End 09/2015
 
Description Wellbeing of Women project grant
Amount £198,503 (GBP)
Funding ID RG1644 
Organisation Wellbeing of Women 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2013 
End 08/2015
 
Description Wellcome Trust - project grant
Amount £471,504 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2008 
End 03/2010
 
Description gy full4health
Amount £299,913 (GBP)
Funding ID 266408 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2011 
End 12/2016
 
Title Barracuda 
Description BarraCUDA is a next generation sequencing alignment software to map sequencing reads to reference genomes using NVIDIA graphics cards. 
Type Of Material Data analysis technique 
Year Produced 2012 
Provided To Others? Yes  
Impact impacts resulting from the use of barraCUDA will become evident in future 
 
Title metabolic cages 
Description In collaboration with Creative Solutions (The Ideas Studio), we have designed new metabolic cages that monitor movement, food preference, and food and water consumption. The system is an improvement on the currently available CLAMS system. 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact The system is now commercially available 
 
Description Brain lipotoxicity and hyperthyroidism 
Organisation University of Edinburgh
Department Centre for Integrative Physiology
Country United Kingdom 
Sector Academic/University 
PI Contribution ongoing intellectual and experimental collaboration
Collaborator Contribution access to facilities and expertise not otherwise available
Impact paper in preparation
 
Description Brain lipotoxicity and hyperthyroidism. 
Organisation University of Santiago de Compostela
Country Spain 
Sector Academic/University 
PI Contribution ongoing intellectual and experimental collaboration
Collaborator Contribution Access to animal physiology facilities not readily available in the UK
Impact CNS STUDIES, PMID: 20802499, 18542011, 20335227, 20299470, 18977694 , 18499762, 18460330, 18308842,
Start Year 2008
 
Description CNS studies in rodents. 
Organisation University of Santiago de Compostela
Country Spain 
Sector Academic/University 
PI Contribution ongoing intellectual and experimental collaboration
Collaborator Contribution acess to facilities that would otherwise not be readily available
Impact CNS STUDIES, PMID: 20802499, 20335227, 20299470, 18977694 , 18499762, 18460330, 18308842
Start Year 2008
 
Description Diet and metabolic syndrome. 
Organisation University of Cordoba
Country Spain 
Sector Academic/University 
PI Contribution ongoing intellectual and experimental collaboration
Collaborator Contribution access to facilities and expertise not otherwise available
Impact PMID 17384344, 17914131
Start Year 2008
 
Description EU FP7 Etherpaths 
Organisation Moscow State University
Country Russian Federation 
Sector Academic/University 
PI Contribution coordinator of workpackage for Etherpaths EU FP7 consortium
Collaborator Contribution access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available
Impact participation in regular meetings of consortium member, which bring increased networking and collaborative opportunities
Start Year 2009
 
Description EU FP7 Etherpaths 
Organisation Nestlé Research Center
Country Switzerland 
Sector Private 
PI Contribution coordinator of workpackage for Etherpaths EU FP7 consortium
Collaborator Contribution access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available
Impact participation in regular meetings of consortium member, which bring increased networking and collaborative opportunities
Start Year 2009
 
Description EU FP7 Etherpaths 
Organisation Noray Bioinformatics SLU
Country Spain 
Sector Private 
PI Contribution coordinator of workpackage for Etherpaths EU FP7 consortium
Collaborator Contribution access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available
Impact participation in regular meetings of consortium member, which bring increased networking and collaborative opportunities
Start Year 2009
 
Description EU FP7 Etherpaths 
Organisation University of Barcelona
Country Spain 
Sector Academic/University 
PI Contribution coordinator of workpackage for Etherpaths EU FP7 consortium
Collaborator Contribution access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available
Impact participation in regular meetings of consortium member, which bring increased networking and collaborative opportunities
Start Year 2009
 
Description EU FP7 Etherpaths 
Organisation University of Barcelona
Country Spain 
Sector Academic/University 
PI Contribution coordinator of workpackage for Etherpaths EU FP7 consortium
Collaborator Contribution access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available
Impact participation in regular meetings of consortium member, which bring increased networking and collaborative opportunities
Start Year 2009
 
Description EU FP7 Etherpaths 
Organisation University of Naples
Department Medical School Naples
Country Italy 
Sector Academic/University 
PI Contribution coordinator of workpackage for Etherpaths EU FP7 consortium
Collaborator Contribution access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available
Impact participation in regular meetings of consortium member, which bring increased networking and collaborative opportunities
Start Year 2009
 
Description EU FP7 MITIN 
Organisation Barcelona Biomedical Research Park
Country Spain 
Sector Public 
PI Contribution coordinator of workpackage for MITIN EU FP7 consortium
Collaborator Contribution access to facilities and expertise not otherwise available
Impact regular scientific and networking meetings allows greater opportunities for collaboration between partners
Start Year 2009
 
Description EU FP7 MITIN 
Organisation Barcelona Supercomputing Center
Country Spain 
Sector Charity/Non Profit 
PI Contribution coordinator of workpackage for MITIN EU FP7 consortium
Collaborator Contribution access to facilities and expertise not otherwise available
Impact regular scientific and networking meetings allows greater opportunities for collaboration between partners
Start Year 2009
 
Description EU FP7 MITIN 
Organisation German Cancer Research Center
Country Germany 
Sector Public 
PI Contribution coordinator of workpackage for MITIN EU FP7 consortium
Collaborator Contribution access to facilities and expertise not otherwise available
Impact regular scientific and networking meetings allows greater opportunities for collaboration between partners
Start Year 2009
 
Description EU FP7 MITIN 
Organisation University of Liverpool
Department School of Life Sciences Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution coordinator of workpackage for MITIN EU FP7 consortium
Collaborator Contribution access to facilities and expertise not otherwise available
Impact regular scientific and networking meetings allows greater opportunities for collaboration between partners
Start Year 2009
 
Description EURoCHIP 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Coordinator of the whole collaborative grant, plus workpackage leader
Collaborator Contribution experimental data and resourcescollaborative awardcollaborative grantcollaborative grantcollaborative awardcollaborative award, requires input from all the partners
Impact No tangible outcomes as yet, although regular scientific meetings of consortium members provides valuable opportunities for newtorking and increasing collaboration between consortium members
Start Year 2009
 
Description EURoCHIP 
Organisation National Center for Scientific Research (Centre National de la Recherche Scientifique CNRS)
Department UMR 8090 (Institute of Biology, Pasteur Institute of Lille)
Country France 
Sector Public 
PI Contribution Coordinator of the whole collaborative grant, plus workpackage leader
Collaborator Contribution experimental data and resourcescollaborative awardcollaborative grantcollaborative grantcollaborative awardcollaborative award, requires input from all the partners
Impact No tangible outcomes as yet, although regular scientific meetings of consortium members provides valuable opportunities for newtorking and increasing collaboration between consortium members
Start Year 2009
 
Description EURoCHIP 
Organisation Unilever
Country United Kingdom 
Sector Private 
PI Contribution Coordinator of the whole collaborative grant, plus workpackage leader
Collaborator Contribution experimental data and resourcescollaborative awardcollaborative grantcollaborative grantcollaborative awardcollaborative award, requires input from all the partners
Impact No tangible outcomes as yet, although regular scientific meetings of consortium members provides valuable opportunities for newtorking and increasing collaboration between consortium members
Start Year 2009
 
Description EURoCHIP 
Organisation University of Cologne
Country Germany 
Sector Academic/University 
PI Contribution Coordinator of the whole collaborative grant, plus workpackage leader
Collaborator Contribution experimental data and resourcescollaborative awardcollaborative grantcollaborative grantcollaborative awardcollaborative award, requires input from all the partners
Impact No tangible outcomes as yet, although regular scientific meetings of consortium members provides valuable opportunities for newtorking and increasing collaboration between consortium members
Start Year 2009
 
Description EURoCHIP 
Organisation University of Gothenburg
Country Sweden 
Sector Academic/University 
PI Contribution Coordinator of the whole collaborative grant, plus workpackage leader
Collaborator Contribution experimental data and resourcescollaborative awardcollaborative grantcollaborative grantcollaborative awardcollaborative award, requires input from all the partners
Impact No tangible outcomes as yet, although regular scientific meetings of consortium members provides valuable opportunities for newtorking and increasing collaboration between consortium members
Start Year 2009
 
Description EURoCHIP 
Organisation University of Potsdam
Department German Institute for Human Nutrition
Country Germany 
Sector Academic/University 
PI Contribution Coordinator of the whole collaborative grant, plus workpackage leader
Collaborator Contribution experimental data and resourcescollaborative awardcollaborative grantcollaborative grantcollaborative awardcollaborative award, requires input from all the partners
Impact No tangible outcomes as yet, although regular scientific meetings of consortium members provides valuable opportunities for newtorking and increasing collaboration between consortium members
Start Year 2009
 
Description Eurochip 
Organisation Cochin Institute
Country France 
Sector Academic/University 
PI Contribution Three members of the research team are co-investigators in the EU FP7 'EurOCHIP' consortium for the 'Study of the Hypothalamus and its interaction with the periphery'. We initiated the consortium, coordinated preparation of the proposal and are coordinator for the consortium.
Impact Consortium started in Nov 2009 The value of this award for Cambridge is ~£550000
Start Year 2009
 
Description Eurochip 
Organisation Euroquality
Country France 
Sector Private 
PI Contribution Three members of the research team are co-investigators in the EU FP7 'EurOCHIP' consortium for the 'Study of the Hypothalamus and its interaction with the periphery'. We initiated the consortium, coordinated preparation of the proposal and are coordinator for the consortium.
Impact Consortium started in Nov 2009 The value of this award for Cambridge is ~£550000
Start Year 2009
 
Description Eurochip 
Organisation Imperial College London
Department Faculty of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Three members of the research team are co-investigators in the EU FP7 'EurOCHIP' consortium for the 'Study of the Hypothalamus and its interaction with the periphery'. We initiated the consortium, coordinated preparation of the proposal and are coordinator for the consortium.
Impact Consortium started in Nov 2009 The value of this award for Cambridge is ~£550000
Start Year 2009
 
Description Eurochip 
Organisation Leibniz Association
Department German Institute of Human Nutrition (DIfE)
Country Germany 
Sector Public 
PI Contribution Three members of the research team are co-investigators in the EU FP7 'EurOCHIP' consortium for the 'Study of the Hypothalamus and its interaction with the periphery'. We initiated the consortium, coordinated preparation of the proposal and are coordinator for the consortium.
Impact Consortium started in Nov 2009 The value of this award for Cambridge is ~£550000
Start Year 2009
 
Description Eurochip 
Organisation National Center for Scientific Research (Centre National de la Recherche Scientifique CNRS)
Department UMR 8090 (Institute of Biology, Pasteur Institute of Lille)
Country France 
Sector Public 
PI Contribution Three members of the research team are co-investigators in the EU FP7 'EurOCHIP' consortium for the 'Study of the Hypothalamus and its interaction with the periphery'. We initiated the consortium, coordinated preparation of the proposal and are coordinator for the consortium.
Impact Consortium started in Nov 2009 The value of this award for Cambridge is ~£550000
Start Year 2009
 
Description Eurochip 
Organisation University of Cologne
Country Germany 
Sector Academic/University 
PI Contribution Three members of the research team are co-investigators in the EU FP7 'EurOCHIP' consortium for the 'Study of the Hypothalamus and its interaction with the periphery'. We initiated the consortium, coordinated preparation of the proposal and are coordinator for the consortium.
Impact Consortium started in Nov 2009 The value of this award for Cambridge is ~£550000
Start Year 2009
 
Description Eurochip 
Organisation University of Gothenburg
Country Sweden 
Sector Academic/University 
PI Contribution Three members of the research team are co-investigators in the EU FP7 'EurOCHIP' consortium for the 'Study of the Hypothalamus and its interaction with the periphery'. We initiated the consortium, coordinated preparation of the proposal and are coordinator for the consortium.
Impact Consortium started in Nov 2009 The value of this award for Cambridge is ~£550000
Start Year 2009
 
Description IGFBP2 and metabolic syndrome 
Organisation University of Leeds
Country United Kingdom 
Sector Academic/University 
PI Contribution ongoing intellectual and experimental collaboration
Collaborator Contribution access to facilities and expertise not otherwise available
Impact Co-investigators on BHF award
Start Year 2007
 
Description INFLAMATION/LIPID METABOLISM 
Organisation Leiden University Medical Center
Country Netherlands 
Sector Multiple 
PI Contribution Supervised the work of 2 PhD students
Collaborator Contribution funded 2 PhD students
Impact none as yet
Start Year 2009
 
Description LPGD2S and energy expenditure. 
Organisation Osaka University
Country Japan 
Sector Academic/University 
PI Contribution ongoing intellectual and experimental collaboration
Collaborator Contribution access to facilities and expertise not otherwise available
Impact no tangible outputs outputs as yet
 
Description Lipotoxicity and Gaucher Disease. 
Organisation University of Adelaide
Country Australia 
Sector Academic/University 
PI Contribution ongoing intellectual and experimental collaboration
Collaborator Contribution access to facilities and expertise not otherwise available
Impact no tangible outputs as yet
Start Year 2007
 
Description MRC CORD 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution Expertise on human intervention studies, and translating basic obesity research into clinical and public health outcomes.
Collaborator Contribution Collaborators undertake basic experimental and human studies to improve our understanding of obesity and related metabolic diseases.
Impact Training of PhD students
Start Year 2008
 
Description MRC CORD 
Organisation University of Cambridge
Department Cambridge Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution Expertise on human intervention studies, and translating basic obesity research into clinical and public health outcomes.
Collaborator Contribution Collaborators undertake basic experimental and human studies to improve our understanding of obesity and related metabolic diseases.
Impact Training of PhD students
Start Year 2008
 
Description Macrophages and lipotoxicity. 
Organisation Spanish Ministry of Health and Consumer Affairs
Department National Center for Cardiovascular Research (CNIC)
Country Spain 
Sector Public 
PI Contribution ongoing intellectual and experimental collaboration
Collaborator Contribution access to facilities and expertise not otherwise available
Impact publication in preparation
Start Year 2007
 
Description Mouse cardiovascular phenotyping. 
Organisation University of Utah
Country United States 
Sector Academic/University 
PI Contribution ongoing intellectual and experimental collaboration
Collaborator Contribution access to expertise not otherwise available
Impact PMID: 17090215, PMID: 9726236
 
Description PGCs and Bone biology 
Organisation National Center for Geriatrics and Gerontology (NCGG)
Department Department of Bone and Joint Disease
Country Japan 
Sector Hospitals 
PI Contribution ongoing intellectual and experimental collaboration
Collaborator Contribution access to facilities and expertise not otherwise available
Impact PMID:19252502
Start Year 2007
 
Description PGCs and RIP140 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution ongoing intellectual and experimental collaboration
Collaborator Contribution access to facilities and expertise not otherwise available
Impact none as yet
Start Year 2007
 
Description PGCs in liver. 
Organisation University of Bari
Country Italy 
Sector Academic/University 
PI Contribution ongoing intellectual and experimental collaboration
Collaborator Contribution access to facilities and expertise not otherwise available
Impact no tangible outputs as yet
Start Year 2008
 
Description PPAR? and myocardial fibrosis 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution ongoing intellectual and experimental collaboration
Collaborator Contribution access to facilities and expertise not otherwise available
Impact PMID:19395708
Start Year 2007
 
Description PPARgamma2 and asthma 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution ongoing intellectual and experimental collaboration
Collaborator Contribution access to facilities and expertise not otherwise available
Impact collaboration started in 2009. There are tangible outcomes to report as yet
Start Year 2007
 
Description WNT signaling and adipogenesis 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution ongoing intellectual and experimental collaboration
Collaborator Contribution access to facilities and expertise not otherwise available
Impact PMID: 20514047, 19772894, 19073771, 19008118 , 18445670
Start Year 2007
 
Description amylin corp 
Organisation Amylin Pharmaceuticals
Country United States 
Sector Private 
PI Contribution identification of suitable patients
Collaborator Contribution provision of recombinant leptin for human use
Impact clinical benefits for patients. to be reported
 
Description mitochondrial biogenesis 
Organisation AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution ongoing intellectual and experimental collaboration
Collaborator Contribution collaborative discussions
Impact PMID: 20802499, 19536672, 19252502, 18974884, 18460330,
Start Year 2007
 
Description studies on the identification of biomarkers 
Organisation Pfizer Ltd
Country United Kingdom 
Sector Private 
PI Contribution development of biomarkers of FTO activity
Collaborator Contribution scientific discussions
Impact novel informationb re FTO
Start Year 2008
 
Description systems biology/lipidomics 
Organisation Technical Research Centre of Finland (VTT)
Country Finland 
Sector Academic/University 
PI Contribution expertise in experimental physiology
Collaborator Contribution systems biology, bioinformatics/lipidomics analyses and input
Impact PMID 20802499, 20514047, 19841237, 19341506, 18951641, 18213405
 
Description Bilbao, Spain. 1st March 2017. Seminar at Biofisika, Basque Centre for Biophysics. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Bilbao, Spain. 1st March 2017. Seminar at Biofisika, Basque Centre for Biophysics. Lecture. Networking with engineers.
Year(s) Of Engagement Activity 2017
URL http://biofisika.org/
 
Description Boston, USA. 11th May 2018. "Adventures in Metabolism" Symposium at Harvard Medical School. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Boston, USA. 11th May 2018. "Adventures in Metabolism" Symposium at Harvard Medical School. Lecture related to the role of Brown fat in metabolism.
Year(s) Of Engagement Activity 2018
URL https://www.evensi.us/adventures-metabolism-symposium-celebrate-jeffrey-flier-70th-birthday/25406324...
 
Description Keystone Symposia on Diabetes/Obesity and Adipose Tissue Biology. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Keystone Conference Lecture. Colorado, USA. 22nd - 27th January 2017.
Year(s) Of Engagement Activity 2017
URL http://healthdocbox.com/amp/69735120-Diabetes/Diabetes-january-22-26-2017-keystone-conference-center...
 
Description Mexico. 13th-14th February 2019. Nutrition Forum 2019 Danone Institute of Mexico. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on obesity and nutrition
Year(s) Of Engagement Activity 2018
URL https://www.danoneinstitute.org/nutrition-health/local-initiatives
 
Description Naples, Italy. 28th May 2018. Seminar at The Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" of the National Research Council (CNR). 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Naples, Italy. 28th May 2018. Seminar at The Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" of the National Research Council (CNR). Lecture on the Adipose tissue expandability, lipotoxicity and metabolic syndrome.
Year(s) Of Engagement Activity 2018
 
Description World Forum on Scientific & Technological Innovation in London. Looking for solutions to the emerging epidemic of ageing related health problems in China 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Highlights from the World Forum on Scientific & Technological Innovation in London. Looking for solutions to the emerging epidemic of ageing related health problems in China
Year(s) Of Engagement Activity 2018
URL https://www.linkedin.com/in/toni-vidal-puig-md-phd-frcp-fmedsci-emba-43804113/detail/recent-activity...
 
Description Örebro/Sweden. 26th-28th August 2018. Nordic Metabolomics Conference. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Örebro/Sweden. 26th-28th August 2018. Nordic Metabolomics Conference. Role of lipidomics in metabolic research
Opening keynote lecture
Antonio Vidal-Puig (University of Cambridge, UK)
"Adipose tissue expandability, lipotoxicity and the metabolic syndrome"
Year(s) Of Engagement Activity 2018
URL https://www.oru.se/english/about-us/conferences/nordic-metabolomics-conference/program/
 
Description 2nd Metabolomics Sardinian Scientific School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 2nd Metabolomics Sardinian Scientific School was aimed at post-grad students new to the field of metabolomics. We gave seminars and workshops in various tools and techniques in metabolomics.
Year(s) Of Engagement Activity 2016
 
Description 4. Bradford, UK. 1st December 2018. SRUK Seminar (Society of Spanish Researchers in the UK). 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact 4. Bradford, UK. 1st December 2018. SRUK Seminar (Society of Spanish Researchers in the UK).
Year(s) Of Engagement Activity 2018
URL https://www.eventbrite.co.uk/e/v-christmas-seminar-science-of-healthy-diet-sports-wellbeing-tickets-...
 
Description 6. Sheffield, UK. 10th-11th September 2018. The British Society for Cardiovascular Research Autumn Meeting 'Inflammation and repair'. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact 6. Sheffield, UK. 10th-11th September 2018. The British Society for Cardiovascular Research Autumn Meeting 'Inflammation and repair'.
Year(s) Of Engagement Activity 2018
URL https://bscr.org/event/bscr-autumn-meeting-2018-inflammation-and-repair/
 
Description Advances in obesity 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact Invited lecture at the RCPath annual conference

Raising awareness in the research area for professionals
Year(s) Of Engagement Activity 2006
 
Description BA Festival of Science 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Speaker 'Fat of the land or land of the fat?' session

increased awareness of both environmental and genetic causes of obesity and the desire to eat
Year(s) Of Engagement Activity 2008
 
Description BAT in Granada 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Interested in Brown Adipose Tissue? Can't miss this Symposium! https://finut-en.congressus.es/symposiumbat/index @ibsGRANADA @CIBER_OBN @TVPLab @FIBAO @CanalUGR @finutibero
Year(s) Of Engagement Activity 2018
URL https://twitter.com/ruizruizjonatan/status/1024216467729010688?s=12
 
Description Basel, Switzerland. 11th-14th September 2018. EMBO at Basel Life. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 2. Basel, Switzerland. 11th-14th September 2018. EMBO at Basel Life.
Year(s) Of Engagement Activity 2018
URL https://www.basellife.org/basel-life-2018.html
 
Description Bilbao, Spain. 8th June 2018. Seminar at Biogune. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 7. Bilbao, Spain. 8th June 2018. Seminar at Biogune.
Year(s) Of Engagement Activity 2018
URL https://twitter.com/CICbioGUNE
 
Description Café Scientifique 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact gave presentation at Cambridge meeting of Café Scientifique 'Are your genes to blame when your jeans don't fit?'

provoked debate between audience members and speaker
Year(s) Of Engagement Activity 2010
 
Description Cambridge Metabolic Network/Danish Diabetes Association Course for PhD Students. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Course sponsored by NOVO foundation from Denmark, 35 PhD students from Cambridge and Denmark.
Year(s) Of Engagement Activity 2017
URL https://www.danishdiabetesacademy.dk/events/lipid-metabolism-new-methods-and-translational-aspects
 
Description EPOS2019 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Wehosted the 2020 Horizon EPoS project Steering commitee meeting at St Catherine College in Cambridge to discuss the latest results on the pathogenesis, diagnostic and treatment of fatty liver and NASH.
Year(s) Of Engagement Activity 2019
URL https://www.linkedin.com/in/toni-vidal-puig-md-phd-frcp-fmedsci-emba-43804113/detail/recent-activity...
 
Description Farewell symposium for Henrik Mortensen, Copenhagen 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Festschrift to celebrate the career of a distinguished Danish Paediatric Endocrinologist
Year(s) Of Engagement Activity 2018
 
Description Genetic basis of obesity 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact lecture presentation to the 41st Annual meeting of the European Society for Clinical Investigation

Raised awareness of our work and the area for scientists and clinicians
Year(s) Of Engagement Activity 2007
 
Description Genetic causes of obesity 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact Berzelius symposium, Umea

improved knowledge of health professionals regarding advances in obesity
Year(s) Of Engagement Activity 2008
 
Description Genetic contributions to type 1 diabetes (The Endocrine Society, USA) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited to lecture in the USA by the Endocrine Society - a symposium concerning studies of early prediction and prevention of type 1 diabetes.
Year(s) Of Engagement Activity 2017
URL https://www.endocrine.org
 
Description Genetics of Human Obesity 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Invited presentation at the 8th European Congress of Endocrinology.

Raised awareness of our studies and the genetic basis of obesity among endocrinologists
Year(s) Of Engagement Activity 2006
 
Description Genetics of obesity and diabetes 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Invited presentation to the 9th WHO/IDF Seminar on the Epidemiology and Public Health Aspects of Diabetes Mellitus. The international audience included epidemiologists and public health practitioners

Raised awareness of our work and the area in general to an international public health audience
Year(s) Of Engagement Activity 2006
 
Description Genetics of obesity: food for thought 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact presentation of our work to a public audience at the Dana Centre, London

Raised awareness of the genetic basis of obesity to a general audience
Year(s) Of Engagement Activity 2006
 
Description Gothenburg, Sweden. 5th October 2018. Wallenberg Lab 30th Anniversary Symposium. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Gothenburg, Sweden. 5th October 2018. Wallenberg Lab 30th Anniversary Symposium.
Year(s) Of Engagement Activity 2018
 
Description Human obesity & insulin resistance: lessons from the extremes 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Health professionals
Results and Impact presentation as the Wilkins Visiting Professor for Evan Days

improved knowledge of health professionals regarding advances in obesity
Year(s) Of Engagement Activity 2008
 
Description Human obesity: science versus stigma 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Gave the Annual Wade lecture at the University of Southampton School of Medicine's foundation. This lecture is aimed at enhancing public understanding of medicine and science

improved public understanding of the genetic factors that underlie obesity
Year(s) Of Engagement Activity 2007
 
Description Human obesity: science vs stigma 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Presented the 'In praise of medicine' public leture, Erasmus University, The Netherlands

Raised awareness of genetic determinants of obesity and overweight
Year(s) Of Engagement Activity 2007
 
Description INNODIA - what do we aim for and how to find the needle (ISPAD) International Society for Pediatric and Adolecent Diabetes 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lecture to an international group describing how a new EU programme (INNODIA [co-lead David Dunger]) may impact on type 1 diabetes research
Year(s) Of Engagement Activity 2017
URL https://www.innodia.eu/
 
Description Insulin-like growth factor 1 and preterm infants (British Association of Perinatal Medicine) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited lecture to a professional group of neonatalogists (nurses.doctors) concerning studies of IGF-1 in preterm infants.
Year(s) Of Engagement Activity 2017
 
Description Introduction to the Cambridge Baby Growth Study (BioFN Kick off meeting) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact start up meeting to plan a new European Research grant.
Year(s) Of Engagement Activity 2017
 
Description Lessons from human phenotypes of obesity and insulin resistance 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Invited presentation to specialist academic researchers and clinicians at the 51st meeting of the Japan Diabetes Society

Raised awareness of our work to an internation audience
Year(s) Of Engagement Activity 2008
 
Description Lessons from studies of the genetics of syndromic forms of metabolic traits 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Invited lecture at the EASD Genomics of hyperglycaemia International Symposium, Denmark

Raised awareness of the genetic basis of obesity and type 2 diabetes for health professionals
Year(s) Of Engagement Activity 2006
 
Description MIddle EaSt obesity 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Professors Toni Vidal-Puig MD PhD FRCP FMedSci EMBA and Meis Moukayed have honoured us by writing the fascinating article, People with obesity: Their heroic battle to defeat their genes in a hostile hypercaloric sedentary environment. The professors explain why more than 50 human genes, the environment and lifestyle culture all contribute to why it is not so easy as the doctor telling the patient to lose weight. In addition to looking at the 'why' of obesity,
Year(s) Of Engagement Activity 2018
URL https://www.middleeastmedicalportal.com/product/november-december-2018/
 
Description Madrid, Spain. 22nd November 2018. CIBEROBN Annual Symposium. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Madrid, Spain. 22nd November 2018. CIBEROBN Annual Symposium.
Year(s) Of Engagement Activity 2018
URL https://www.ciberobn.es/en
 
Description Mature student lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Gave a presentation to mature students at the University of Cambridge, organised by the Cambridge Admissions Office

unknown as yet
Year(s) Of Engagement Activity 2010
 
Description Mente y Cerebro article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Article entitled 'Claves para entender la pandemia de obesidad' in the Spanish language edition of the popular magazine Scientific American (authors, Tan and Vidal-Puig)

Raised awarenes and interest in scientific studies of body weight regulation
Year(s) Of Engagement Activity 2007
 
Description Mexico Instituto Zubiran de Nutricion 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Supporters
Results and Impact Seminar evaluation PhD students projects
Year(s) Of Engagement Activity 2019
URL https://www.linkedin.com/in/toni-vidal-puig-md-phd-frcp-fmedsci-emba-43804113/detail/recent-activity...
 
Description Nephrology - what have we learnt from AdDIT (ADOLESCENT TYPE 1 DIABETES CARDIO-RENAL INTERVENTION TRIAL)National Paediatric and Adolescent Diabetes Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact update on the progress of AdDIT study
Year(s) Of Engagement Activity 2018
URL http://www.addit-trial.org/
 
Description Oxford, UK. 18th January 2019. Seminar in Department of Physiology, Anatomy & Genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Oxford, UK. 18th January 2019. Seminar in Department of Physiology, Anatomy & Genetics
Date: 18 January 2019, 13:00 (Friday, 1st week, Hilary 2019)
Venue:
Sherrington Building
off Parks Road OX1 3PT
See location on maps.ox

Details: Large Lecture Theatre
Speaker: Professor Antonio Vidal-Puig (University of Cambridge)
Organising department: Department of Physiology, Anatomy and Genetics (DPAG)
Organiser contact email address: ana.domingos@dpag.ox.ac.uk
Host: Dr Ana Domingos (University of Oxford, DPAG)
Part of: DPAG Head of Department Seminar Series
Topics: Inflammation, Diabetes, Adipose tissues, Metabolic syndrome, Obesity
Year(s) Of Engagement Activity 2018
URL https://new.talks.ox.ac.uk/talks/id/f6ae26ed-6a85-4ea6-8236-0be648588540/
 
Description Paris, France. 11th-15th April 2018. EASL International Liver Congress. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation at the Paris, France. 11th-15th April 2018. EASL International Liver Congress focused on the pathogenesis of fatty liver and the effect of Lipotoxicty
Year(s) Of Engagement Activity 2018
URL https://easl.eu/discover/events/detail/2018/the-international-liver-congress-2018
 
Description Patient Participation and Involvement within CPRU National Childrens Bureau, London 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact about 30 children were involved in workshop activities to discuss a research project - patient and public involvement
Year(s) Of Engagement Activity 2018
 
Description Public debate 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact spoke at Public debate exploring the causes, solutions and implications of the 'obesity epidemic''

increased awareness of both environmental and genetic causes of obesity and the desire to eat
Year(s) Of Engagement Activity 2008
 
Description Royal Swedish Academy of Sciences, Journal of Internal Medicine - Key Symposium "Metabolic complications of obesity" 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Organisation of symposia with 150 attendants, 28 speakers from EU, USA, JAPAN, CHINA. Top symposium supported by the Swedish Academy of Sciences and the Journal of Internal Medicine.
Year(s) Of Engagement Activity 2017
URL http://www.mrl.ims.cam.ac.uk/event/metabolic-complications-obesity/
 
Description SOR Academy of Medical Sciences 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Raised awareness of research and IMS

None
Year(s) Of Engagement Activity 2013
 
Description SOR Award Lecture for Zulch prize 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Raised awareness of research and IMS

Prestigious award of Zulch prize
Year(s) Of Engagement Activity 2014
URL http://www.mpg.de/8406171/zuelch_award_2014_orahilly_friedman
 
Description SOR BBC TV and Radio Interviews 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Raise awareness of research and IMS to the public

None
Year(s) Of Engagement Activity 2013
 
Description SOR CSAR talk, University of Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Gave talk at Cambridge Society for the Application of Research on "Human Metabolic Disease, Lessons from the Extremes"

Raised awareness of research and of IMS
Year(s) Of Engagement Activity 2014
URL http://www.csar.org.uk/index.html
 
Description SOR CSaP 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Member of Centre for Science & Policy Executive Committee, University of Cambridge

None
Year(s) Of Engagement Activity 2013,2014
 
Description SOR Doha talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Invited guest speaker at Academic Health System lecture series at Hamad Medical Corporation, Doha, Qatar

Raise awareness of research and IMS
Year(s) Of Engagement Activity 2014
 
Description SOR Dublin Science Gallery 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Invited speaker at Trinity College Dublin Science Gallery as part of exhibition and 'Lab in the Gallery' FAT LAB. The goal of FAT LAB is to initiate a widespread re-evaluation of the perception of fat by inviting visitors to the gallery to participate in real research experiments and by creating a series of talks and events to engage our target audience of 15-25 year olds.

Raise awareness of research and IMS
Year(s) Of Engagement Activity 2014
URL https://dublin.sciencegallery.com/video/2014/07/sciencefatstephenorahillyanddonaloshea
 
Description SOR JCI Interview-Conversations with Giants in Medicine 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Raised awareness of research and IMS

None
Year(s) Of Engagement Activity 2013
URL http://www.jci.org/videos/cgms
 
Description SOR MRC Centenary Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Raised awareness of research and IMS among public

None
Year(s) Of Engagement Activity 2013
 
Description SOR MedSOC talk, Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Invited speaker at MedSOC talk, University of Cambridge

Raise awareness of research and of IMS
Year(s) Of Engagement Activity 2014
 
Description SOR Naked Scientist Question of the Week 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Raised awareness of research and IMS to public

None
Year(s) Of Engagement Activity 2013
URL http://www.thenakedscientists.com/HTML/podcasts/qotw/show/20130307/
 
Description SOR National Health and Medical Research Council (NHMRC) CEO Obesity Roundtable 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Health professionals
Results and Impact Participated in roundtable discussion with members of Australian Government National Health and MRC and others

Raise awareness of research and IMS
Year(s) Of Engagement Activity 2014
 
Description SOR Pharmacology tea club talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Invited to give University of Cambridge Department of Pharmacology tea club talk

Raise awareness of research and of IMS
Year(s) Of Engagement Activity 2014
 
Description SOR RTE interviews 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Raised awareness of research and IMS to the public

None
Year(s) Of Engagement Activity 2013
 
Description SOR Research Lecture Karolinska Institute, Stockholm 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Raised awareness of research and IMS among peers

None
Year(s) Of Engagement Activity 2013
 
Description SOR SAC Conway 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Scientific Advisory Board

None
Year(s) Of Engagement Activity 2013
 
Description SOR SAC Crick Institute 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Scientific Advisory Board

None
Year(s) Of Engagement Activity 2013
 
Description SOR SAC Fondation Leducq 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Scientific Advisory Committee

None
Year(s) Of Engagement Activity 2013,2014
 
Description SOR UCD MGA presentation lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Gave presentation when awarded Medical Graduates Association Distinguished Graduate Award from University College Dublin for 2014

Raised awareness of research and IMS
Year(s) Of Engagement Activity 2014
URL http://www.ucd.ie/medicine/ourcommunity/ouralumni/
 
Description SOR University of Bristol talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Invited speaker at University of Bristol MRC IEU Seminar Series

Raise awareness of research and IMS
Year(s) Of Engagement Activity 2014
 
Description SOR University of Leuven 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Gave talk at University of Leuven, Belgium in seminar series for high profile scientists aimed at broad audience

Raised awareness of research and IMS
Year(s) Of Engagement Activity 2014
 
Description SOR University of Manchester talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Invited speaker at University of Manchester at Faculty's Life Science 'Leaders in Science' Lecture Series

Raise awareness of research and IMS
Year(s) Of Engagement Activity 2014
 
Description SOR University of the Third Age, Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Invited to give talk at University of the Third Age in Cambridge

Raise awareness of research and IMS
Year(s) Of Engagement Activity 2014
 
Description Schools Masterclasses series 2009 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact lectured to GCSE students in the Schools Masterclasses series, in which GCSE students are invited to Cambridge for a day of talks and tours.

improved students awareness of recent advances in obestity research and in the genetic basis of common obesity. Was asked by an audience member to speak at another school event in Moulton College
Year(s) Of Engagement Activity 2009,2010,2011,2012
 
Description Singapore2019 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact University of Cambridge meets with our colleagues from the National University of Singapore to strenght our collaborative cardiovascular research network.
Year(s) Of Engagement Activity 2019
 
Description Talk: Genetic and Lipidomic Associations with pregnancy and newborn outcomes in the Cambridge Baby Growth Study 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact update on academic progress several aspects of the Cambridge Baby Growth Study.
Year(s) Of Engagement Activity 2016
URL http://paediatrics.medschl.cam.ac.uk/research/clinical-trials/cambridge-baby-growth-study/
 
Description Talk:Coordinated appproaches to the identification of clinical useful biomarkers 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Research In progress seminar series: update on recent work with Cambridge Baby Growth Study and the AdDIT study.
Year(s) Of Engagement Activity 2017
URL http://paediatrics.medschl.cam.ac.uk/research/clinical-trials/cambridge-baby-growth-study/
 
Description The Biochemist article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Article entitled 'The metabolic sydrome - where do we go from here?' in the popular magazine The Biochemist.

difficult to assess at present
Year(s) Of Engagement Activity 2009
 
Description The genetic basis of obesity 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Invited lecture o the International Congress of Endocrinology, Sydney, Australia

Raised awareness of our research group and the area for professionals
Year(s) Of Engagement Activity 2006
 
Description Tye 2 Diabetes; Atherapeutic avenue is emerging 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Date:December 5, 2018 Source:INSERM (Institut national de la santé et de la recherche médicale) Summary:Restoring the action of insulin is one of the keys to fighting type 2 diabetes. Researchers are developing a therapeutic strategy that uses the properties of an enzyme (hormone-sensitive lipase) which, when stimulating fatty-acid synthesis in the fat cells, has a beneficial effect on insulin action.
Year(s) Of Engagement Activity 2018
URL https://www.sciencedaily.com/releases/2018/12/181205134014.htm
 
Description Update on nephropathy - when do we treat (American Diabetes Association) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lecture at the Annual Meeting of the American Diabetes Association reporting the results of a large international study AdDIT (ADOLESCENT TYPE 1 DIABETES CARDIO-RENAL INTERVENTION TRIAL)
Year(s) Of Engagement Activity 2017
URL http://www.addit-trial.org/
 
Description WT vacation students 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Hosted two 10 week laboratory project for undergraduate students

students have gone on to higher degrees in life sciences
Year(s) Of Engagement Activity 2010,2011
 
Description Workshop advisor 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Expert advisor at the Wellcome Trust workshop for Public Engagement Society Awards 'Eating'

was later consulted by several groups preparing to apply to the Engaging Science Society Awards programme which aim to engage people with developments in biomedical science on a regional or national scale.
Year(s) Of Engagement Activity 2009
 
Description https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283
November 27, 2018
Could this be a solution for the obesity crisis?
Samuel Virtue, University of Cambridge; Antonio Vidal-Puig, University of Cambridge, and Vanessa Pellegrinelli, University of Cambridge
Scientists manage to boost brown fat in mice with a molecule called BMP8b. Could this be the future for treating obesity?
Year(s) Of Engagement Activity 2018
URL https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283
 
Description work experience students 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Hosted several work experience placements for 6th form students in the laboratory

Increased awareness of sceintific methods to enthusiastic 6-form students, and encouraged their ambitions for a scientific career. The experience caused 1 student to study biology at A level
Year(s) Of Engagement Activity 2007,2008,2009
 
Description work experience, 6th form student 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact hosted work experience placement for local 6th form student

Student loved their stay on the lab and went on to study biology at A level
Year(s) Of Engagement Activity 2009