MRC Centre for Translational Research in Obesity and related Metabolic Diseases
Lead Research Organisation:
University of Cambridge
Department Name: Clinical Biochemist
Abstract
Obesity is a major cause of premature death and disability. Obesity is particularly closely linked to the development of diabetes, with its attendant risks of blindness, kidney failure and amputation. These diseases are becoming more common. They both result from a combination of lifestyle factors and genetic susceptibility. Now that we are beginning to make strides in understanding the nature of these genetic and lifestyle factors, we need to better understand exactly how they interact to result in disease. When we do so, we will be in a much better position to target our attempts at prevention and treatment in the right way to the right individuals.
This application comes from a group of scientists, some based in basic science laboratories, some working with patients, yet others working in the area of public health. We want to bring our individual skills and knowledge together to create a Centre for research in obesity and diabetes that is greater than the sum of its parts. Through charitable and other sources we have already raised #20M for a new building in Cambridge to act as the hub for this Centre and are now looking to the MRC to help us to provide the core research facilities (including equipment and specialised technical staff) required for our studies. The MRC funding would also enable us to increase the number of students we train in this important but relatively neglected area.
This application comes from a group of scientists, some based in basic science laboratories, some working with patients, yet others working in the area of public health. We want to bring our individual skills and knowledge together to create a Centre for research in obesity and diabetes that is greater than the sum of its parts. Through charitable and other sources we have already raised #20M for a new building in Cambridge to act as the hub for this Centre and are now looking to the MRC to help us to provide the core research facilities (including equipment and specialised technical staff) required for our studies. The MRC funding would also enable us to increase the number of students we train in this important but relatively neglected area.
Technical Summary
Obesity is a major threat to public health in the UK and internationally. The clearest impact of obesity on health is through its influence on insulin resistance,diabetes and dyslipidaemia. Improved understanding of the fundamental causes of obesity and how it impacts on insuln resistance, diabetes and vascular risk will be critically important to the design of effective strategies for treatment and prevention.
We propose the establishment of a new MRC Centre for Translational Research in Obesity and Related Metabolic Disease (MRC CTROM) which exploits the existing collaborative interactions between internationally renowned clinical and basic scientists at the University of Cambridge, relevant MRC Units within the Cambridge area, the Wellcome Trust Sanger Institute and Oxford University. We believe that the collective expertise and reputation of this group of investigators will provide a unique intellectual synergy with the capability of becoming a world-leading centre for translational research in this crucially important area of biomedical research.
We propose the establishment of a new MRC Centre for Translational Research in Obesity and Related Metabolic Disease (MRC CTROM) which exploits the existing collaborative interactions between internationally renowned clinical and basic scientists at the University of Cambridge, relevant MRC Units within the Cambridge area, the Wellcome Trust Sanger Institute and Oxford University. We believe that the collective expertise and reputation of this group of investigators will provide a unique intellectual synergy with the capability of becoming a world-leading centre for translational research in this crucially important area of biomedical research.
Organisations
- University of Cambridge, United Kingdom (Lead Research Organisation)
- University of Edinburgh, United Kingdom (Collaboration)
- University of Gothenburg, Sweden (Collaboration)
- Model Animal Research Center (MARC) Nanjing (Collaboration)
- Osaka University, Japan (Collaboration)
- Newcastle University, United Kingdom (Collaboration)
- University of Bari Aldo Moro (Collaboration)
- Chiba University, Japan (Collaboration)
- PA Consulting Group (Collaboration)
- University of Cambridge (Collaboration)
- University of Liverpool, United Kingdom (Collaboration)
- University of Santiago de Compostela (Collaboration)
- Euroquality (Collaboration)
- Unilever R&D Vlaardingen B.V., Netherlands (Collaboration)
- AstraZeneca plc (Collaboration)
- Cochin Institute (Collaboration)
- University of Utah, United States (Collaboration)
- University of Cordoba, Spain (Collaboration)
- Leiden University Medical Center (Collaboration)
- Leibniz Association (Collaboration)
- European Commission, Belgium (Collaboration)
- Spanish National Centre for Cardiovascular Research (Collaboration)
- Rey Juan Carlos University Hospital (Collaboration)
- Amylin Pharmaceuticals (Collaboration)
- University of Oxford, United Kingdom (Collaboration)
- Nestlé (Global) (Collaboration)
- Imperial College London, United Kingdom (Collaboration)
- Barcelona Biomedical Research Park (Collaboration)
- VTT Technical Research Centre of Finland Ltd (Collaboration)
- Medical Research Council (Collaboration)
- National Center for Geriatrics and Gerontology (NCGG) (Collaboration)
- University of Leeds, United Kingdom (Collaboration)
- British Heart Foundation (BHF) (Collaboration)
- Nanjing University, China (Collaboration)
- Pfizer Ltd (Collaboration)
- University of Cologne, Germany (Collaboration)
- Noray Bioinformatics SLU (Collaboration)
- National Center for Scientific Research (Centre National de la Recherche Scientifique CNRS) (Collaboration)
- German Cancer Research Center (Collaboration)
- University of Adelaide, Australia (Collaboration)
- University of Naples (Collaboration)
- Barcelona Supercomputing Center, Spain (Collaboration)
- University of Barcelona, Spain (Collaboration)
- University of Potsdam, Germany (Collaboration)
- King's College London, United Kingdom (Collaboration)
- EMBL - European Bioinformatics Institute, United Kingdom (Collaboration)
Publications
Acharjee A
(2017)
The translation of lipid profiles to nutritional biomarkers in the study of infant metabolism.
in Metabolomics : Official journal of the Metabolomic Society
Agostini M
(2018)
A Pharmacogenetic Approach to the Treatment of Patients With PPARG Mutations.
in Diabetes
Agrawal M
(2019)
Fat storage-inducing transmembrane protein 2 (FIT2) is less abundant in type 2 diabetes, and regulates triglyceride accumulation and insulin sensitivity in adipocytes.
in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Aiken CE
(2013)
Sex differences in developmental programming models.
in Reproduction (Cambridge, England)
Aiken CE
(2013)
Suboptimal nutrition in utero causes DNA damage and accelerated aging of the female reproductive tract.
in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Aiken CE
(2014)
Transgenerational developmental programming.
in Human reproduction update
Alfaradhi MZ
(2014)
Oxidative stress and altered lipid homeostasis in the programming of offspring fatty liver by maternal obesity.
in American journal of physiology. Regulatory, integrative and comparative physiology
Allum F
(2015)
Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants.
in Nature communications
Araiz C
(2019)
Enhanced ß-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110a inactivation in adipose tissue.
in Nature communications
Arias De La Rosa I
(2018)
Defective glucose and lipid metabolism in rheumatoid arthritis is determined by chronic inflammation in metabolic tissues.
in Journal of internal medicine
| Description | Brussels, Belgium. 18th- 21st June 2019. European Research Council -2019-STG - LS4, Step 2. |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | 4. Brussels, Belgium. 18th- 21st June 2019. European Research Council -2019-STG - LS4, Step 2. Chair Panel selecting awardees ERC starting grant. Decision of science and work force |
| Description | Academy of Medical Sciences Clinical Lecturer Starter Grant (30,000) |
| Amount | £30,000 (GBP) |
| Organisation | Academy of Medical Sciences (AMS) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2019 |
| Description | BBSRC - project grant |
| Amount | £513,407 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2009 |
| End | 09/2012 |
| Description | BBSRC/DRINC Diet and Health Research Industry Club |
| Amount | £549,226 (GBP) |
| Funding ID | BB/MO27252/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 10/2019 |
| Description | BHF (AdDIT) |
| Amount | £1,268,755 (GBP) |
| Funding ID | SP/071002/23394 07CC14 RPAG/065 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2008 |
| End | 03/2017 |
| Description | BHF - project grant |
| Amount | £145,520 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2008 |
| End | 12/2009 |
| Description | BRC NIHR Biomedical Research Centre |
| Amount | £750,810 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2012 |
| End | 03/2017 |
| Description | British Council - exchange award |
| Amount | £4,617 (GBP) |
| Organisation | British Council |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2009 |
| End | 12/2009 |
| Description | DUK (AdDIT) |
| Amount | £1,260,132 (GBP) |
| Funding ID | BDA:RD06/003341 |
| Organisation | Diabetes UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2007 |
| End | 10/2017 |
| Description | Diabetes UK |
| Amount | £1,260,132 (GBP) |
| Funding ID | RG66036 |
| Organisation | Diabetes UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2007 |
| End | 05/2016 |
| Description | Diabetes UK Extension -AdDIT |
| Amount | £469,281 (GBP) |
| Funding ID | 12/0004468 |
| Organisation | Diabetes UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2012 |
| End | 08/2016 |
| Description | EC FP6 - collaborative award |
| Amount | £45,500 (GBP) |
| Organisation | Sixth Framework Programme (FP6) |
| Sector | Public |
| Country | European Union (EU) |
| Start | 08/2007 |
| End | 09/2009 |
| Description | ERC senior investigator |
| Amount | € 2,500,000 (EUR) |
| Funding ID | StemBAT |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 01/2015 |
| End | 12/2023 |
| Description | EU FP7 - COLLABORATIVE AWARD EUROCHIP |
| Amount | £437,332 (GBP) |
| Funding ID | 241592 |
| Organisation | European Commission |
| Department | Seventh Framework Programme (FP7) |
| Sector | Public |
| Country | European Union (EU) |
| Start | 09/2009 |
| End | 09/2013 |
| Description | EU FP7 - collaborative award |
| Amount | £599,000 (GBP) |
| Organisation | European Commission |
| Department | Seventh Framework Programme (FP7) |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | EU FP7 - collaborative award |
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| Organisation | European Commission |
| Department | Seventh Framework Programme (FP7) |
| Sector | Public |
| Country | European Union (EU) |
| Start | 03/2010 |
| End | 03/2011 |
| Description | EU FP7 - collaborative award |
| Amount | £490,606 (GBP) |
| Organisation | European Commission |
| Department | Seventh Framework Programme (FP7) |
| Sector | Public |
| Country | European Union (EU) |
| Start | 09/2008 |
| End | 09/2012 |
| Description | EU FP7 - collaborative award, MITIN |
| Amount | £347,129 (GBP) |
| Funding ID | 223450 |
| Organisation | European Commission |
| Department | Seventh Framework Programme (FP7) |
| Sector | Public |
| Country | European Union (EU) |
| Start | 11/2008 |
| End | 10/2011 |
| Description | FP7 Health.2012.2.4.4-1 |
| Amount | € 2,696,648 (EUR) |
| Funding ID | PREVENTROP305485 RPAG/110 |
| Organisation | European Commission |
| Department | Seventh Framework Programme (FP7) |
| Sector | Public |
| Country | European Union (EU) |
| Start | 03/2013 |
| End | 02/2018 |
| Description | FP7 IMI Litmus "Liver Investigation: Testing Marker Utility in Steatohepatitis" (15M euro investment of EU and >15M by EFPIA). 2017-2021. £650,000 |
| Amount | € 15,000,000 (EUR) |
| Funding ID | FP7 IMI Litmus "Liver Investigation: Testing Marker Utility in Steatohepatitis |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 01/2017 |
| End | 12/2023 |
| Description | GSK - collaborative grant |
| Amount | £41,533 (GBP) |
| Organisation | GlaxoSmithKline (GSK) |
| Sector | Private |
| Country | Global |
| Start | 01/2008 |
| End | 12/2010 |
| Description | Gates Foundation |
| Amount | $623,000 (USD) |
| Funding ID | RG 67603 |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 01/2013 |
| End | 12/2016 |
| Description | Grant for Growth Innovation (Merck) Effect of insulin sensitisation on Insulin-Like Growth Factor-1 in response to Growth Hormone treatment in children born small for gestational age. |
| Amount | € 200,000 (EUR) |
| Organisation | Merck |
| Department | Merck UK |
| Sector | Private |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 12/2018 |
| Description | Greater Glasgow Health Board |
| Amount | £5,000 (GBP) |
| Funding ID | GN10KH234 rg64806 |
| Organisation | NHS Greater Glasgow and Clyde (NHSGGC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2011 |
| End | 08/2016 |
| Description | Horizon 2020 "Elucidating Pathways of Steatohepatitis (EPoS)". 2013-2017. £500,000 |
| Amount | £3,500,000 (GBP) |
| Organisation | European Commission H2020 |
| Sector | Public |
| Country | Belgium |
| Start | |
| Description | IMI2 H2020-JTI-IM 12-2014-01-01 |
| Amount | € 2,930,000 (EUR) |
| Funding ID | 115797 |
| Organisation | European Commission |
| Department | Innovative Medicines Initiative (IMI) |
| Sector | Public |
| Country | Belgium |
| Start | 11/2015 |
| End | 10/2022 |
| Description | INTERBIO subcontract |
| Amount | $500,000 (USD) |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 08/2012 |
| End | 08/2014 |
| Description | Infancy lipidoemic profiles, breast milk fat intake and infancy growth in collaboration with Cambridge-Africa growth cohorts |
| Amount | £7,250 (GBP) |
| Organisation | Alborada Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2014 |
| End | 09/2015 |
| Description | JDRF |
| Amount | $142,000 (USD) |
| Funding ID | 3-SRA-2016-332-M-R |
| Organisation | Juvenile Diabetes Research Foundation (JDRF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 09/2018 |
| Description | JDRF (AdDIT) |
| Amount | $4,995,843 (USD) |
| Funding ID | Ref 08-2007-902 |
| Organisation | Juvenile Diabetes Research Foundation (JDRF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2007 |
| End | 08/2017 |
| Description | JDRF Overnight closed loop in sub-optimally controlled type 1 diabetes under free living conditions (APCam11) |
| Amount | $1,187,530 (USD) |
| Funding ID | 2-SRA-2014-256-M-R |
| Organisation | Juvenile Diabetes Research Foundation (JDRF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2014 |
| End | 08/2016 |
| Description | JDRF Validation of novel and candidate biomarkers for diabetic kidney disease in large cohorts of people with type 1 diabetes |
| Amount | $1,995,784 (USD) |
| Funding ID | 2-SRA-2014-277-m-r |
| Organisation | Juvenile Diabetes Research Foundation (JDRF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2014 |
| End | 09/2017 |
| Description | JPI-HDHL Biomarkers (Joint Programme Initiataive - Healthy Diet Healthy Lifestyle) |
| Amount | € 1,034,440 (EUR) |
| Funding ID | BB/PO28195/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 03/2020 |
| Description | Juvenile Diabetes Research Foundation |
| Amount | $4,995,843 (USD) |
| Funding ID | RG49109 AdDIT |
| Organisation | Juvenile Diabetes Research Foundation (JDRF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2007 |
| End | 08/2016 |
| Description | MRC - translational research initiative |
| Amount | £665,546 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2008 |
| End | 02/2010 |
| Description | Medical Research Council |
| Amount | £661,216 (GBP) |
| Funding ID | G0800661 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2009 |
| End | 04/2014 |
| Description | Medical Research Council (MRC) |
| Amount | £150,000 (GBP) |
| Funding ID | MR/P021174/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Medical Research Council/Training Fellowship (PP) |
| Amount | £193,037 (GBP) |
| Funding ID | G1001995 ID:98634 RG61566 |
| Organisation | Medical Research Council (MRC) |
| Department | MRC National Institute for Medical Research (NIMR) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2007 |
| End | 03/2014 |
| Description | NIH RO1 |
| Amount | $3,000,000 (USD) |
| Funding ID | R01DK107786 |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | 08/2017 |
| End | 06/2021 |
| Description | NIHR EME |
| Amount | £677,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2013 |
| End | 09/2016 |
| Description | NIHR Type 2 diabetes in childhood building a platform to support novel intervention strategies |
| Amount | £199,885 (GBP) |
| Organisation | University of Birmingham |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2013 |
| End | 03/2017 |
| Description | Programme grant |
| Amount | £1,245,413 (GBP) |
| Funding ID | RG/18/7/33636 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2018 |
| End | 05/2023 |
| Description | Research Grant |
| Amount | £121,153 (GBP) |
| Funding ID | 11/0004241 |
| Organisation | Diabetes UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2011 |
| End | 11/2013 |
| Description | The European Federation of Pharmaceutical Industries and Associations/Research Project: SUMMiT |
| Amount | € 235,000 (EUR) |
| Funding ID | 115006/999977172 |
| Organisation | European Federation of Pharmaceutical Industries and Associations (EFPIA) |
| Sector | Private |
| Country | Belgium |
| Start | 11/2009 |
| End | 10/2014 |
| Description | Thomas Watt Eden Paediatric Fellowship (Dr Philippa Prentice) |
| Amount | £9,700 (GBP) |
| Organisation | Royal College of Physicians of London |
| Department | Thomas Watts Eden Fellowship |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2015 |
| End | 09/2015 |
| Description | Wellbeing of Women project grant |
| Amount | £198,503 (GBP) |
| Funding ID | RG1644 |
| Organisation | Wellbeing of Women |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2013 |
| End | 08/2015 |
| Description | Wellcome Investigator Award |
| Amount | £1,601,565 (GBP) |
| Funding ID | 210755/Z/18/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2018 |
| End | 07/2023 |
| Description | Wellcome Trust - project grant |
| Amount | £471,504 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2008 |
| End | 03/2010 |
| Description | gy full4health |
| Amount | £299,913 (GBP) |
| Funding ID | 266408 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 01/2011 |
| End | 12/2016 |
| Title | Barracuda |
| Description | BarraCUDA is a next generation sequencing alignment software to map sequencing reads to reference genomes using NVIDIA graphics cards. |
| Type Of Material | Data analysis technique |
| Year Produced | 2012 |
| Provided To Others? | Yes |
| Impact | impacts resulting from the use of barraCUDA will become evident in future |
| Title | Combining Stable Isotopes with calorimetry to investigate free-living nutrient utilisation in the fed state |
| Description | Combining Stable Isotopes with calorimetry to investigate free-living nutrient utilisation in the fed state This is an improvement in the methodology that allows us to study insulin sensitivity without radioactivity in animals that are not sedated and recapitulate more physiological conditions. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice. Girousse A, Virtue S, Hart D, Vidal-Puig A, Murgatroyd PR, Mouisel E, Sengenès C, Savage DB. Mol Metab. 2018 Jul;13:24-29. doi: 10.1016/j.molmet.2018.05.006. Epub 2018 May 16. |
| URL | https://www.ncbi.nlm.nih.gov/pubmed/29789270 |
| Title | Thermogenesis related in vivo phenotyping |
| Description | 1) Combined Calorimetry and BAT temperature measurements at thermoneutrality 2) New Statistical methods to assess Norepinepherine turnover |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | Methodology allows refined evaluation of thermogenic defects originated at the CNS level by looking at the effect of the sympathetic nervous system in periphery under conditions of activation and inactivation. |
| URL | https://elifesciences.org/articles/22848 |
| Title | metabolic cages |
| Description | In collaboration with Creative Solutions (The Ideas Studio), we have designed new metabolic cages that monitor movement, food preference, and food and water consumption. The system is an improvement on the currently available CLAMS system. |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | The system is now commercially available |
| Description | Brain lipotoxicity and hyperthyroidism |
| Organisation | University of Edinburgh |
| Department | Centre for Integrative Physiology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | ongoing intellectual and experimental collaboration |
| Collaborator Contribution | access to facilities and expertise not otherwise available |
| Impact | paper in preparation |
| Description | Brain lipotoxicity and hyperthyroidism. |
| Organisation | University of Santiago de Compostela |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | ongoing intellectual and experimental collaboration |
| Collaborator Contribution | Access to animal physiology facilities not readily available in the UK |
| Impact | CNS STUDIES, PMID: 20802499, 18542011, 20335227, 20299470, 18977694 , 18499762, 18460330, 18308842, |
| Start Year | 2008 |
| Description | CNS studies in rodents. |
| Organisation | University of Santiago de Compostela |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | ongoing intellectual and experimental collaboration |
| Collaborator Contribution | acess to facilities that would otherwise not be readily available |
| Impact | CNS STUDIES, PMID: 20802499, 20335227, 20299470, 18977694 , 18499762, 18460330, 18308842 |
| Start Year | 2008 |
| Description | Chiba University |
| Organisation | Chiba University |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | Technology and animal models |
| Collaborator Contribution | Salary support for postdoctoral fellow |
| Impact | 1. Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms. Lee E, Miedzybrodzka EL, Zhang X, Hatano R, Miyamoto J, Kimura I, Fujimoto K, Uematsu S, Rodriguez-Cuenca S, Vidal-Puig A, Gribble FM, Reimann F, Miki T. Int J Mol Sci. 2019 Sep 10;20(18). pii: E4448. doi: 10.3390/ijms20184448. PMID: 31509948 Free PMC Article Similar articles Select item 26615883 2.Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. PMID: 26615883 Free PMC Article Similar articles Select item 26584636 3.Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A, Bujo H. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951. Li J, Zhang Y, Ye Y, Li D, Liu Y, Lee E, Zhang M, Dai X, Zhang X, Wang S, Zhang J, Jia W, Zen K, Vidal-Puig A, Jiang X, Zhang CY. Pancreatic ß cells control glucose homeostasis via the secretion of exosomal miR-29 family. J Extracell Vesicles. 2021 Jan;10(3):e12055. doi: 10.1002/jev2.12055. Epub 2021 Jan 21. PMID: 33520119 |
| Start Year | 2018 |
| Description | Collaboration with University Rey Juan carlos Madrid. |
| Organisation | Rey Juan Carlos University Hospital |
| Country | Spain |
| Sector | Hospitals |
| PI Contribution | Provided animal models to study Kidney lipotoxicity |
| Collaborator Contribution | Provided expertise in murine characterisation of kidney phenotypes. Provide expertise in murine metabolic phenotyping |
| Impact | 1 Obesity and pregnancy, the perfect metabolic storm. Corrales P, Vidal-Puig A, Medina-Gómez G. Eur J Clin Nutr. 2021 Dec;75(12):1723-1734. doi: 10.1038/s41430-021-00914-5. Epub 2021 Apr 28. PMID: 33911209 Review. 2. Autocrine IGF2 programmes ß-cell plasticity under conditions of increased metabolic demand. Sandovici I, Hammerle CM, Virtue S, Vivas-Garcia Y, Izquierdo-Lahuerta A, Ozanne SE, Vidal-Puig A, Medina-Gómez G, Constância M. Sci Rep. 2021 Apr 8;11(1):7717. doi: 10.1038/s41598-021-87292-x. PMID: 33833312 Free PMC article. 3. Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function. Hammerle CM, Sandovici I, Brierley GV, Smith NM, Zimmer WE, Zvetkova I, Prosser HM, Sekita Y, Lam BYH, Ma M, Cooper WN, Vidal-Puig A, Ozanne SE, Medina-Gómez G, Constância M. PLoS Genet. 2020 Oct 15;16(10):e1009069. doi: 10.1371/journal.pgen.1009069. eCollection 2020 Oct. PMID: 33057429 Transforming Growth Factor-ß3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue. Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding KL, Vidal-Puig A, Medina-Gomez G, Arner P, Rydén M. Cell Rep. 2018 Oct 16;25(3):551-560.e5. doi: 10.1016/j.celrep.2018.09.069. PMID: 30332637 Free Article 4.PPARs and Metabolic Disorders Associated with Challenged Adipose Tissue Plasticity. Corrales P, Vidal-Puig A, Medina-Gómez G. Int J Mol Sci. 2018 Jul 21;19(7). pii: E2124. doi: 10.3390/ijms19072124. Review. PMID: 30037087 Free PMC Article 5. Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešic M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M. Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014. PMID: 28683288 F |
| Start Year | 2019 |
| Description | Diet and metabolic syndrome. |
| Organisation | University of Cordoba |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | ongoing intellectual and experimental collaboration |
| Collaborator Contribution | access to facilities and expertise not otherwise available |
| Impact | PMID 17384344, 17914131 |
| Start Year | 2008 |
| Description | EU FP7 Etherpaths |
| Organisation | Moscow State University |
| Country | Russian Federation |
| Sector | Academic/University |
| PI Contribution | coordinator of workpackage for Etherpaths EU FP7 consortium |
| Collaborator Contribution | access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available |
| Impact | participation in regular meetings of consortium member, which bring increased networking and collaborative opportunities |
| Start Year | 2009 |
| Description | EU FP7 Etherpaths |
| Organisation | Nestlé (Global) |
| Department | Société des Produits Nestlé SA |
| Country | Switzerland |
| Sector | Private |
| PI Contribution | coordinator of workpackage for Etherpaths EU FP7 consortium |
| Collaborator Contribution | access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available |
| Impact | participation in regular meetings of consortium member, which bring increased networking and collaborative opportunities |
| Start Year | 2009 |
| Description | EU FP7 Etherpaths |
| Organisation | Noray Bioinformatics SLU |
| Country | Spain |
| Sector | Private |
| PI Contribution | coordinator of workpackage for Etherpaths EU FP7 consortium |
| Collaborator Contribution | access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available |
| Impact | participation in regular meetings of consortium member, which bring increased networking and collaborative opportunities |
| Start Year | 2009 |
| Description | EU FP7 Etherpaths |
| Organisation | University of Barcelona |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | coordinator of workpackage for Etherpaths EU FP7 consortium |
| Collaborator Contribution | access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available |
| Impact | participation in regular meetings of consortium member, which bring increased networking and collaborative opportunities |
| Start Year | 2009 |
| Description | EU FP7 Etherpaths |
| Organisation | University of Barcelona |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | coordinator of workpackage for Etherpaths EU FP7 consortium |
| Collaborator Contribution | access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available |
| Impact | participation in regular meetings of consortium member, which bring increased networking and collaborative opportunities |
| Start Year | 2009 |
| Description | EU FP7 Etherpaths |
| Organisation | University of Naples |
| Department | Medical School Naples |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | coordinator of workpackage for Etherpaths EU FP7 consortium |
| Collaborator Contribution | access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available access to facilities and expertise not otherwise available |
| Impact | participation in regular meetings of consortium member, which bring increased networking and collaborative opportunities |
| Start Year | 2009 |
| Description | EU FP7 MITIN |
| Organisation | Barcelona Biomedical Research Park |
| Country | Spain |
| Sector | Public |
| PI Contribution | coordinator of workpackage for MITIN EU FP7 consortium |
| Collaborator Contribution | access to facilities and expertise not otherwise available |
| Impact | regular scientific and networking meetings allows greater opportunities for collaboration between partners |
| Start Year | 2009 |
| Description | EU FP7 MITIN |
| Organisation | Barcelona Supercomputing Center |
| Country | Spain |
| Sector | Public |
| PI Contribution | coordinator of workpackage for MITIN EU FP7 consortium |
| Collaborator Contribution | access to facilities and expertise not otherwise available |
| Impact | regular scientific and networking meetings allows greater opportunities for collaboration between partners |
| Start Year | 2009 |
| Description | EU FP7 MITIN |
| Organisation | German Cancer Research Center |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | coordinator of workpackage for MITIN EU FP7 consortium |
| Collaborator Contribution | access to facilities and expertise not otherwise available |
| Impact | regular scientific and networking meetings allows greater opportunities for collaboration between partners |
| Start Year | 2009 |
| Description | EU FP7 MITIN |
| Organisation | University of Liverpool |
| Department | School of Life Sciences Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | coordinator of workpackage for MITIN EU FP7 consortium |
| Collaborator Contribution | access to facilities and expertise not otherwise available |
| Impact | regular scientific and networking meetings allows greater opportunities for collaboration between partners |
| Start Year | 2009 |
| Description | EURoCHIP |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Coordinator of the whole collaborative grant, plus workpackage leader |
| Collaborator Contribution | experimental data and resourcescollaborative awardcollaborative grantcollaborative grantcollaborative awardcollaborative award, requires input from all the partners |
| Impact | No tangible outcomes as yet, although regular scientific meetings of consortium members provides valuable opportunities for newtorking and increasing collaboration between consortium members |
| Start Year | 2009 |
| Description | EURoCHIP |
| Organisation | National Center for Scientific Research (Centre National de la Recherche Scientifique CNRS) |
| Department | UMR 8090 (Institute of Biology, Pasteur Institute of Lille) |
| Country | France |
| Sector | Public |
| PI Contribution | Coordinator of the whole collaborative grant, plus workpackage leader |
| Collaborator Contribution | experimental data and resourcescollaborative awardcollaborative grantcollaborative grantcollaborative awardcollaborative award, requires input from all the partners |
| Impact | No tangible outcomes as yet, although regular scientific meetings of consortium members provides valuable opportunities for newtorking and increasing collaboration between consortium members |
| Start Year | 2009 |
| Description | EURoCHIP |
| Organisation | Unilever |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Coordinator of the whole collaborative grant, plus workpackage leader |
| Collaborator Contribution | experimental data and resourcescollaborative awardcollaborative grantcollaborative grantcollaborative awardcollaborative award, requires input from all the partners |
| Impact | No tangible outcomes as yet, although regular scientific meetings of consortium members provides valuable opportunities for newtorking and increasing collaboration between consortium members |
| Start Year | 2009 |
| Description | EURoCHIP |
| Organisation | University of Cologne |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Coordinator of the whole collaborative grant, plus workpackage leader |
| Collaborator Contribution | experimental data and resourcescollaborative awardcollaborative grantcollaborative grantcollaborative awardcollaborative award, requires input from all the partners |
| Impact | No tangible outcomes as yet, although regular scientific meetings of consortium members provides valuable opportunities for newtorking and increasing collaboration between consortium members |
| Start Year | 2009 |
| Description | EURoCHIP |
| Organisation | University of Gothenburg |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Coordinator of the whole collaborative grant, plus workpackage leader |
| Collaborator Contribution | experimental data and resourcescollaborative awardcollaborative grantcollaborative grantcollaborative awardcollaborative award, requires input from all the partners |
| Impact | No tangible outcomes as yet, although regular scientific meetings of consortium members provides valuable opportunities for newtorking and increasing collaboration between consortium members |
| Start Year | 2009 |
| Description | EURoCHIP |
| Organisation | University of Potsdam |
| Department | German Institute for Human Nutrition |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Coordinator of the whole collaborative grant, plus workpackage leader |
| Collaborator Contribution | experimental data and resourcescollaborative awardcollaborative grantcollaborative grantcollaborative awardcollaborative award, requires input from all the partners |
| Impact | No tangible outcomes as yet, although regular scientific meetings of consortium members provides valuable opportunities for newtorking and increasing collaboration between consortium members |
| Start Year | 2009 |
| Description | Eurochip |
| Organisation | Cochin Institute |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Three members of the research team are co-investigators in the EU FP7 'EurOCHIP' consortium for the 'Study of the Hypothalamus and its interaction with the periphery'. We initiated the consortium, coordinated preparation of the proposal and are coordinator for the consortium. |
| Impact | Consortium started in Nov 2009 The value of this award for Cambridge is ~£550000 |
| Start Year | 2009 |
| Description | Eurochip |
| Organisation | Euroquality |
| Country | France |
| Sector | Private |
| PI Contribution | Three members of the research team are co-investigators in the EU FP7 'EurOCHIP' consortium for the 'Study of the Hypothalamus and its interaction with the periphery'. We initiated the consortium, coordinated preparation of the proposal and are coordinator for the consortium. |
| Impact | Consortium started in Nov 2009 The value of this award for Cambridge is ~£550000 |
| Start Year | 2009 |
| Description | Eurochip |
| Organisation | Imperial College London |
| Department | Faculty of Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Three members of the research team are co-investigators in the EU FP7 'EurOCHIP' consortium for the 'Study of the Hypothalamus and its interaction with the periphery'. We initiated the consortium, coordinated preparation of the proposal and are coordinator for the consortium. |
| Impact | Consortium started in Nov 2009 The value of this award for Cambridge is ~£550000 |
| Start Year | 2009 |
| Description | Eurochip |
| Organisation | Leibniz Association |
| Department | German Institute of Human Nutrition (DIfE) |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Three members of the research team are co-investigators in the EU FP7 'EurOCHIP' consortium for the 'Study of the Hypothalamus and its interaction with the periphery'. We initiated the consortium, coordinated preparation of the proposal and are coordinator for the consortium. |
| Impact | Consortium started in Nov 2009 The value of this award for Cambridge is ~£550000 |
| Start Year | 2009 |
| Description | Eurochip |
| Organisation | National Center for Scientific Research (Centre National de la Recherche Scientifique CNRS) |
| Department | UMR 8090 (Institute of Biology, Pasteur Institute of Lille) |
| Country | France |
| Sector | Public |
| PI Contribution | Three members of the research team are co-investigators in the EU FP7 'EurOCHIP' consortium for the 'Study of the Hypothalamus and its interaction with the periphery'. We initiated the consortium, coordinated preparation of the proposal and are coordinator for the consortium. |
| Impact | Consortium started in Nov 2009 The value of this award for Cambridge is ~£550000 |
| Start Year | 2009 |
| Description | Eurochip |
| Organisation | University of Cologne |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Three members of the research team are co-investigators in the EU FP7 'EurOCHIP' consortium for the 'Study of the Hypothalamus and its interaction with the periphery'. We initiated the consortium, coordinated preparation of the proposal and are coordinator for the consortium. |
| Impact | Consortium started in Nov 2009 The value of this award for Cambridge is ~£550000 |
| Start Year | 2009 |
| Description | Eurochip |
| Organisation | University of Gothenburg |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Three members of the research team are co-investigators in the EU FP7 'EurOCHIP' consortium for the 'Study of the Hypothalamus and its interaction with the periphery'. We initiated the consortium, coordinated preparation of the proposal and are coordinator for the consortium. |
| Impact | Consortium started in Nov 2009 The value of this award for Cambridge is ~£550000 |
| Start Year | 2009 |
| Description | FAtty Liver |
| Organisation | EMBL European Bioinformatics Institute (EMBL - EBI) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Murine studies to identify NASH biomarkers and molecular mechanisms of disease. Important input from the point of lipid metabolism in macrophages and signalling in Kupffer cells and stellate cells. |
| Collaborator Contribution | Newcastle: Leader 2020 Horizon Epoos and IMI Litmus. Access to human data EBI: Bioinformatic analysis - PhD Studetship |
| Impact | Funding 2020 Epoos and IMIM Litmus 1. Johnson K, Leary PJ, Govaere O, Barter MJ, Charlton SH, Cockell SJ, Tiniakos D, Zatorska M, Bedossa P, Brosnan MJ, Cobbold JF, Ekstedt M, Aithal GP, Clément K, Schattenberg JM, Boursier J, Ratziu V, Bugianesi E, Anstee QM, Daly AK; LITMUS Consortium Investigators. Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance. JHEP Rep. 2021 Nov 25;4(2):100409. doi: 10.1016/j.jhepr.2021.100409. PMID: 35072021 PMCID: PMC8762473 2. Rao S, Yang X, Ohshiro K, Zaidi S, Wang Z, Shetty K, Xiang X, Hassan MI, Mohammad T, Latham PS, Nguyen BN, Wong L, Yu H, Al-Abed Y, Mishra B, Vacca M, Guenigault G, Allison MED, Vidal-Puig A, Benhammou JN, Alvarez M, Pajukanta P, Pisegna JR, Mishra L. ß2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development. Sci Transl Med. 2021 Dec 15;13(624):eabk2267. doi:10.1126/scitranslmed.abk2267. PMID: 34910547 3. Mózes FE, Lee JA, Selvaraj EA, Jayaswal ANA, Trauner M, Boursier J, Fournier C, Staufer K, Stauber RE, Bugianesi E, Younes R, Gaia S, Lup?or-Platon M, Petta S, Shima T, Okanoue T, Mahadeva S, Chan WK, Eddowes PJ, Newsome PN, Wong VW, de Ledinghen V, Fan J, Shen F, Cobbold JF, Sumida Y, Okajima A, Schattenberg JM, Labenz C, Kim W, Lee MS, Wiegand J, Karlas T, Yilmaz Y, Aithal GP, Palaniyappan N, Cassinotto C, Aggarwal S, Garg H, Ooi GJ, Nakajima A, Yoneda M, Ziol M, Barget N, Geier A, Tuthill T, Brosnan MJ, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators. Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis. Gut. 2021 May 17:gutjnl-2021-324243. doi: 10.1136/gutjnl-2021-324243. PMID: 34001645 4. Selvaraj EA, Mózes FE, Ajmer Jayaswal AN, Zafarmand MH, Vali Y, Lee JA, Levick CK, Joseph Young LA, Palaniyappan N, Liu CH, Aithal GP, Romero-Gómez M, Brosnan MJ, Tuthill TA, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators. Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis. J Hepatol. 2021 May 12:S0168-8278(21)00309-3. doi: 10.1016/j.jhep.2021.04.044. PMID: 33991635 5. Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies SE, Lukasik A, Dale M, Bohlooly-Y M, Acharjee A, Lindén D, Bidault G, Petsalaki E, Griffin JL, Oakley F, Allison MED, Vidal-Puig A. Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. Mol Metab 1012-10. 2021. PMID:33722690 6. Govaere O, Cockell S, Tiniakos D, Queen R, Younes R, Vacca M, Alexander L, Ravaioli F, Palmer J, Petta S, Boursier J, Rosso C, Johnson K, Wonders K, Day CP, Ekstedt M, Orešic M, Darlay R, Cordell HJ, Marra F, Vidal-Puig A, Bedossa P, Schattenberg JM, Clément K, Allison M, Bugianesi E, Ratziu V, Daly AK, Anstee QM. Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis. Sci Transl Med. 2020 Dec 2;12(572):eaba4448.doi:10.1126/scitranslmed.aba4448. PMID: 33268509 7. Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease. Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A. Gastroenterology. 2020 Feb 12. pii: S0016-5085(20)30224-9. doi: 10.1053/j.gastro.2019.12.054. [Epub ahead of print] PMID: 32061598 Similar articles Select item 27863448 8.Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Hepatology. 2017 Apr;65(4):1165-1180. doi: 10.1002/hep.28953. Epub 2017 Feb 6. PMID: 27863448 Free PMC Article Similar articles Select item 26378642 9.Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD. Vacca M, Allison M, Griffin JL, Vidal-Puig A. Semin Liver Dis. 2015 Aug;35(3):250-61. doi: 10.1055/s-0035-1562945. Epub 2015 Sep 17. Review. PMID: 26378642 Similar articles |
| Start Year | 2016 |
| Description | FAtty Liver |
| Organisation | European Commission |
| Department | Innovative Medicines Initiative (IMI) |
| Country | Belgium |
| Sector | Public |
| PI Contribution | Murine studies to identify NASH biomarkers and molecular mechanisms of disease. Important input from the point of lipid metabolism in macrophages and signalling in Kupffer cells and stellate cells. |
| Collaborator Contribution | Newcastle: Leader 2020 Horizon Epoos and IMI Litmus. Access to human data EBI: Bioinformatic analysis - PhD Studetship |
| Impact | Funding 2020 Epoos and IMIM Litmus 1. Johnson K, Leary PJ, Govaere O, Barter MJ, Charlton SH, Cockell SJ, Tiniakos D, Zatorska M, Bedossa P, Brosnan MJ, Cobbold JF, Ekstedt M, Aithal GP, Clément K, Schattenberg JM, Boursier J, Ratziu V, Bugianesi E, Anstee QM, Daly AK; LITMUS Consortium Investigators. Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance. JHEP Rep. 2021 Nov 25;4(2):100409. doi: 10.1016/j.jhepr.2021.100409. PMID: 35072021 PMCID: PMC8762473 2. Rao S, Yang X, Ohshiro K, Zaidi S, Wang Z, Shetty K, Xiang X, Hassan MI, Mohammad T, Latham PS, Nguyen BN, Wong L, Yu H, Al-Abed Y, Mishra B, Vacca M, Guenigault G, Allison MED, Vidal-Puig A, Benhammou JN, Alvarez M, Pajukanta P, Pisegna JR, Mishra L. ß2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development. Sci Transl Med. 2021 Dec 15;13(624):eabk2267. doi:10.1126/scitranslmed.abk2267. PMID: 34910547 3. Mózes FE, Lee JA, Selvaraj EA, Jayaswal ANA, Trauner M, Boursier J, Fournier C, Staufer K, Stauber RE, Bugianesi E, Younes R, Gaia S, Lup?or-Platon M, Petta S, Shima T, Okanoue T, Mahadeva S, Chan WK, Eddowes PJ, Newsome PN, Wong VW, de Ledinghen V, Fan J, Shen F, Cobbold JF, Sumida Y, Okajima A, Schattenberg JM, Labenz C, Kim W, Lee MS, Wiegand J, Karlas T, Yilmaz Y, Aithal GP, Palaniyappan N, Cassinotto C, Aggarwal S, Garg H, Ooi GJ, Nakajima A, Yoneda M, Ziol M, Barget N, Geier A, Tuthill T, Brosnan MJ, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators. Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis. Gut. 2021 May 17:gutjnl-2021-324243. doi: 10.1136/gutjnl-2021-324243. PMID: 34001645 4. Selvaraj EA, Mózes FE, Ajmer Jayaswal AN, Zafarmand MH, Vali Y, Lee JA, Levick CK, Joseph Young LA, Palaniyappan N, Liu CH, Aithal GP, Romero-Gómez M, Brosnan MJ, Tuthill TA, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators. Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis. J Hepatol. 2021 May 12:S0168-8278(21)00309-3. doi: 10.1016/j.jhep.2021.04.044. PMID: 33991635 5. Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies SE, Lukasik A, Dale M, Bohlooly-Y M, Acharjee A, Lindén D, Bidault G, Petsalaki E, Griffin JL, Oakley F, Allison MED, Vidal-Puig A. Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. Mol Metab 1012-10. 2021. PMID:33722690 6. Govaere O, Cockell S, Tiniakos D, Queen R, Younes R, Vacca M, Alexander L, Ravaioli F, Palmer J, Petta S, Boursier J, Rosso C, Johnson K, Wonders K, Day CP, Ekstedt M, Orešic M, Darlay R, Cordell HJ, Marra F, Vidal-Puig A, Bedossa P, Schattenberg JM, Clément K, Allison M, Bugianesi E, Ratziu V, Daly AK, Anstee QM. Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis. Sci Transl Med. 2020 Dec 2;12(572):eaba4448.doi:10.1126/scitranslmed.aba4448. PMID: 33268509 7. Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease. Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A. Gastroenterology. 2020 Feb 12. pii: S0016-5085(20)30224-9. doi: 10.1053/j.gastro.2019.12.054. [Epub ahead of print] PMID: 32061598 Similar articles Select item 27863448 8.Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Hepatology. 2017 Apr;65(4):1165-1180. doi: 10.1002/hep.28953. Epub 2017 Feb 6. PMID: 27863448 Free PMC Article Similar articles Select item 26378642 9.Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD. Vacca M, Allison M, Griffin JL, Vidal-Puig A. Semin Liver Dis. 2015 Aug;35(3):250-61. doi: 10.1055/s-0035-1562945. Epub 2015 Sep 17. Review. PMID: 26378642 Similar articles |
| Start Year | 2016 |
| Description | FAtty Liver |
| Organisation | Newcastle University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Murine studies to identify NASH biomarkers and molecular mechanisms of disease. Important input from the point of lipid metabolism in macrophages and signalling in Kupffer cells and stellate cells. |
| Collaborator Contribution | Newcastle: Leader 2020 Horizon Epoos and IMI Litmus. Access to human data EBI: Bioinformatic analysis - PhD Studetship |
| Impact | Funding 2020 Epoos and IMIM Litmus 1. Johnson K, Leary PJ, Govaere O, Barter MJ, Charlton SH, Cockell SJ, Tiniakos D, Zatorska M, Bedossa P, Brosnan MJ, Cobbold JF, Ekstedt M, Aithal GP, Clément K, Schattenberg JM, Boursier J, Ratziu V, Bugianesi E, Anstee QM, Daly AK; LITMUS Consortium Investigators. Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance. JHEP Rep. 2021 Nov 25;4(2):100409. doi: 10.1016/j.jhepr.2021.100409. PMID: 35072021 PMCID: PMC8762473 2. Rao S, Yang X, Ohshiro K, Zaidi S, Wang Z, Shetty K, Xiang X, Hassan MI, Mohammad T, Latham PS, Nguyen BN, Wong L, Yu H, Al-Abed Y, Mishra B, Vacca M, Guenigault G, Allison MED, Vidal-Puig A, Benhammou JN, Alvarez M, Pajukanta P, Pisegna JR, Mishra L. ß2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development. Sci Transl Med. 2021 Dec 15;13(624):eabk2267. doi:10.1126/scitranslmed.abk2267. PMID: 34910547 3. Mózes FE, Lee JA, Selvaraj EA, Jayaswal ANA, Trauner M, Boursier J, Fournier C, Staufer K, Stauber RE, Bugianesi E, Younes R, Gaia S, Lup?or-Platon M, Petta S, Shima T, Okanoue T, Mahadeva S, Chan WK, Eddowes PJ, Newsome PN, Wong VW, de Ledinghen V, Fan J, Shen F, Cobbold JF, Sumida Y, Okajima A, Schattenberg JM, Labenz C, Kim W, Lee MS, Wiegand J, Karlas T, Yilmaz Y, Aithal GP, Palaniyappan N, Cassinotto C, Aggarwal S, Garg H, Ooi GJ, Nakajima A, Yoneda M, Ziol M, Barget N, Geier A, Tuthill T, Brosnan MJ, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators. Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis. Gut. 2021 May 17:gutjnl-2021-324243. doi: 10.1136/gutjnl-2021-324243. PMID: 34001645 4. Selvaraj EA, Mózes FE, Ajmer Jayaswal AN, Zafarmand MH, Vali Y, Lee JA, Levick CK, Joseph Young LA, Palaniyappan N, Liu CH, Aithal GP, Romero-Gómez M, Brosnan MJ, Tuthill TA, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators. Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis. J Hepatol. 2021 May 12:S0168-8278(21)00309-3. doi: 10.1016/j.jhep.2021.04.044. PMID: 33991635 5. Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies SE, Lukasik A, Dale M, Bohlooly-Y M, Acharjee A, Lindén D, Bidault G, Petsalaki E, Griffin JL, Oakley F, Allison MED, Vidal-Puig A. Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. Mol Metab 1012-10. 2021. PMID:33722690 6. Govaere O, Cockell S, Tiniakos D, Queen R, Younes R, Vacca M, Alexander L, Ravaioli F, Palmer J, Petta S, Boursier J, Rosso C, Johnson K, Wonders K, Day CP, Ekstedt M, Orešic M, Darlay R, Cordell HJ, Marra F, Vidal-Puig A, Bedossa P, Schattenberg JM, Clément K, Allison M, Bugianesi E, Ratziu V, Daly AK, Anstee QM. Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis. Sci Transl Med. 2020 Dec 2;12(572):eaba4448.doi:10.1126/scitranslmed.aba4448. PMID: 33268509 7. Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease. Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A. Gastroenterology. 2020 Feb 12. pii: S0016-5085(20)30224-9. doi: 10.1053/j.gastro.2019.12.054. [Epub ahead of print] PMID: 32061598 Similar articles Select item 27863448 8.Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Hepatology. 2017 Apr;65(4):1165-1180. doi: 10.1002/hep.28953. Epub 2017 Feb 6. PMID: 27863448 Free PMC Article Similar articles Select item 26378642 9.Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD. Vacca M, Allison M, Griffin JL, Vidal-Puig A. Semin Liver Dis. 2015 Aug;35(3):250-61. doi: 10.1055/s-0035-1562945. Epub 2015 Sep 17. Review. PMID: 26378642 Similar articles |
| Start Year | 2016 |
| Description | IGFBP2 and metabolic syndrome |
| Organisation | University of Leeds |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | ongoing intellectual and experimental collaboration |
| Collaborator Contribution | access to facilities and expertise not otherwise available |
| Impact | Co-investigators on BHF award |
| Start Year | 2007 |
| Description | INFLAMATION/LIPID METABOLISM |
| Organisation | Leiden University Medical Center |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Supervised the work of 2 PhD students |
| Collaborator Contribution | funded 2 PhD students |
| Impact | none as yet |
| Start Year | 2009 |
| Description | LPGD2S and energy expenditure. |
| Organisation | Osaka University |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | ongoing intellectual and experimental collaboration |
| Collaborator Contribution | access to facilities and expertise not otherwise available |
| Impact | no tangible outputs outputs as yet |
| Description | Lipotoxicity and Gaucher Disease. |
| Organisation | University of Adelaide |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | ongoing intellectual and experimental collaboration |
| Collaborator Contribution | access to facilities and expertise not otherwise available |
| Impact | no tangible outputs as yet |
| Start Year | 2007 |
| Description | MRC CORD |
| Organisation | Newcastle University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise on human intervention studies, and translating basic obesity research into clinical and public health outcomes. |
| Collaborator Contribution | Collaborators undertake basic experimental and human studies to improve our understanding of obesity and related metabolic diseases. |
| Impact | Training of PhD students |
| Start Year | 2008 |
| Description | MRC CORD |
| Organisation | University of Cambridge |
| Department | Cambridge Neuroscience |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise on human intervention studies, and translating basic obesity research into clinical and public health outcomes. |
| Collaborator Contribution | Collaborators undertake basic experimental and human studies to improve our understanding of obesity and related metabolic diseases. |
| Impact | Training of PhD students |
| Start Year | 2008 |
| Description | Macrophage |
| Organisation | British Heart Foundation (BHF) |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Financial support for experiments and research expertise |
| Collaborator Contribution | Research Expertise in worm models of immune disease |
| Impact | Publication under review 1. Bidault G, Virtue S, Petkevicius K, Jolin H, Dugourd A, Guénantin AC, Leggat J, Mahler-Araujo B, Lam BY Marcella K. Ma, Dale M, Carobbio S, Kaser A, Fallon PG, Saez-Rodriguez J, McKenzie ANJ and Vidal-Puig A. SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defenses to promote their alternative activation. Nat Metab. 2021 Sep;3(9):1150-1162. doi: 10.1038/s42255-021-00440-5. Epub 2021 Sep 16. PMID: 34531575 2. Cimino I, Rimmington D, Tung YCL, Lawler K, Larraufie P, Kay RG, Virtue S, Lam BYH, Fagnocchi L, Ma MKL, Saudek V, Zvetkova I, Vidal-Puig A, Yeo GSH, Farooqi IS, Pospisilik JA, Gribble FM, Reimann F, O'Rahilly S, Coll AP. Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity. Sci Rep. 2021 Sep 2;11(1):17571. doi: 10.1038/s41598-021-96278-8.PMID: 34475432 3. Tang P, Virtue S, Goie JYG, Png CW, Guo J, Li Y, Jiao H, Chua YL, Campbell M, Moreno-Navarrete JM, Shabbir A, Fernández-Real JM, Gasser S, Kemeny DM, Yang H, Vidal-Puig A, Zhang Y. Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3. Cell Death Differ. 2021 Jun 5. doi: 10.1038/s41418-021-00798-9. PMID: 34091599 4. Petkevicius K, Bidault G, Virtue S, Newland SA, Dale M, Dugourd A, Saez-Rodriguez J, Mallat Z, Vidal-Puig A. Macrophage beta2-adrenergic receptor is dispensable for the adipose tissue inflammation and function. Mol Metab 1012-20. 2021. PMID:22774223 5. Petkevicius K, Bidault G, Virtue S, Jenkins B, van Dierendonck XAMH, Dugourd A, Saez-Rodriguez J, Stienstra R, Koulman A, Vidal-Puig A. Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation. FASEB J. 2021 Feb;35(2):e21266.doi: 10.1096/fj.202001101R. PMID:33484195 |
| Start Year | 2018 |
| Description | Macrophage |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Laboratory of Molecular Biology (LMB) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Financial support for experiments and research expertise |
| Collaborator Contribution | Research Expertise in worm models of immune disease |
| Impact | Publication under review 1. Bidault G, Virtue S, Petkevicius K, Jolin H, Dugourd A, Guénantin AC, Leggat J, Mahler-Araujo B, Lam BY Marcella K. Ma, Dale M, Carobbio S, Kaser A, Fallon PG, Saez-Rodriguez J, McKenzie ANJ and Vidal-Puig A. SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defenses to promote their alternative activation. Nat Metab. 2021 Sep;3(9):1150-1162. doi: 10.1038/s42255-021-00440-5. Epub 2021 Sep 16. PMID: 34531575 2. Cimino I, Rimmington D, Tung YCL, Lawler K, Larraufie P, Kay RG, Virtue S, Lam BYH, Fagnocchi L, Ma MKL, Saudek V, Zvetkova I, Vidal-Puig A, Yeo GSH, Farooqi IS, Pospisilik JA, Gribble FM, Reimann F, O'Rahilly S, Coll AP. Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity. Sci Rep. 2021 Sep 2;11(1):17571. doi: 10.1038/s41598-021-96278-8.PMID: 34475432 3. Tang P, Virtue S, Goie JYG, Png CW, Guo J, Li Y, Jiao H, Chua YL, Campbell M, Moreno-Navarrete JM, Shabbir A, Fernández-Real JM, Gasser S, Kemeny DM, Yang H, Vidal-Puig A, Zhang Y. Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3. Cell Death Differ. 2021 Jun 5. doi: 10.1038/s41418-021-00798-9. PMID: 34091599 4. Petkevicius K, Bidault G, Virtue S, Newland SA, Dale M, Dugourd A, Saez-Rodriguez J, Mallat Z, Vidal-Puig A. Macrophage beta2-adrenergic receptor is dispensable for the adipose tissue inflammation and function. Mol Metab 1012-20. 2021. PMID:22774223 5. Petkevicius K, Bidault G, Virtue S, Jenkins B, van Dierendonck XAMH, Dugourd A, Saez-Rodriguez J, Stienstra R, Koulman A, Vidal-Puig A. Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation. FASEB J. 2021 Feb;35(2):e21266.doi: 10.1096/fj.202001101R. PMID:33484195 |
| Start Year | 2018 |
| Description | Macrophages and lipotoxicity. |
| Organisation | Spanish National Centre for Cardiovascular Research |
| Country | Spain |
| Sector | Public |
| PI Contribution | ongoing intellectual and experimental collaboration |
| Collaborator Contribution | access to facilities and expertise not otherwise available |
| Impact | publication in preparation |
| Start Year | 2007 |
| Description | Mouse cardiovascular phenotyping. |
| Organisation | University of Utah |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | ongoing intellectual and experimental collaboration |
| Collaborator Contribution | access to expertise not otherwise available |
| Impact | PMID: 17090215, PMID: 9726236 |
| Description | NANJING/SUZHOU |
| Organisation | Model Animal Research Center (MARC) Nanjing |
| Country | China |
| Sector | Academic/University |
| PI Contribution | Provide expertise in murine metabolic phenotyping |
| Collaborator Contribution | Phenotyping of mice and PhD studentship |
| Impact | N/A • Prof. Antonio Vidal-Puig is a concurrent professor at Nanjing University appointed in September of 2017. • A joint lab focusing on non-alcoholic fatty liver disease has been established at MARC in 2017, co-headed by Profs. Antonio Vidal-Puig and Shuai Chen. • Strong collaborative links with professor Chen Yu Zhang at the Institute of Life Sciences of the University of Nanjing to identify mechanism of disease in metabolic disorders. CYZ is one of the leaders in the development of Biology AI 3.0 in Nanjing • Prof. Antonio Vidal-Puig visits Nanjing University at least twice a year and gives lectures. • A joint workshop on metabolic diseases is to be held in May of 2019 in Nanjing. Six scientists including Prof. Antonio Vidal-Puig from Cambridge and 15 scientists from Nanjing University will attend this workshop.Nanjing, China. 19th-25th May 2019. The Sino-UK Cardiovascular disease symposium. Cambridge, United Kingdom. 5th July 2019 Joint work shop by Cambridge University Nanjing Centre of Technology and Innovation, Institute Metabolic Science, University of Cambridge, Model Animals Research Centre (MARC), University of Nanjing. Huang-Doran I, Zhang CY, Vidal-Puig A. Extracellular Vesicles: Novel Mediators of Cell Communication In Metabolic Disease. Trends Endocrinol Metab. 2017 Jan;28(1):3-18. doi: 10.1016/j.tem.2016.10.003. Epub 2016 Oct 31. PMID: 27810172 Review. 2 Cite Share Li J, Zhang Y, Ye Y, Li D, Liu Y, Lee E, Zhang M, Dai X, Zhang X, Wang S, Zhang J, Jia W, Zen K, Vidal-Puig A, Jiang X, Zhang CY. Pancreatic ß cells control glucose homeostasis via the secretion of exosomal miR-29 family.J Extracell Vesicles. 2021 Jan;10(3):e12055. doi: 10.1002/jev2.12055. Epub 2021 Jan 21. PMID: 33520119 Free PMC article. |
| Start Year | 2018 |
| Description | NANJING/SUZHOU |
| Organisation | Nanjing University (NJU) |
| Country | China |
| Sector | Academic/University |
| PI Contribution | Provide expertise in murine metabolic phenotyping |
| Collaborator Contribution | Phenotyping of mice and PhD studentship |
| Impact | N/A • Prof. Antonio Vidal-Puig is a concurrent professor at Nanjing University appointed in September of 2017. • A joint lab focusing on non-alcoholic fatty liver disease has been established at MARC in 2017, co-headed by Profs. Antonio Vidal-Puig and Shuai Chen. • Strong collaborative links with professor Chen Yu Zhang at the Institute of Life Sciences of the University of Nanjing to identify mechanism of disease in metabolic disorders. CYZ is one of the leaders in the development of Biology AI 3.0 in Nanjing • Prof. Antonio Vidal-Puig visits Nanjing University at least twice a year and gives lectures. • A joint workshop on metabolic diseases is to be held in May of 2019 in Nanjing. Six scientists including Prof. Antonio Vidal-Puig from Cambridge and 15 scientists from Nanjing University will attend this workshop.Nanjing, China. 19th-25th May 2019. The Sino-UK Cardiovascular disease symposium. Cambridge, United Kingdom. 5th July 2019 Joint work shop by Cambridge University Nanjing Centre of Technology and Innovation, Institute Metabolic Science, University of Cambridge, Model Animals Research Centre (MARC), University of Nanjing. Huang-Doran I, Zhang CY, Vidal-Puig A. Extracellular Vesicles: Novel Mediators of Cell Communication In Metabolic Disease. Trends Endocrinol Metab. 2017 Jan;28(1):3-18. doi: 10.1016/j.tem.2016.10.003. Epub 2016 Oct 31. PMID: 27810172 Review. 2 Cite Share Li J, Zhang Y, Ye Y, Li D, Liu Y, Lee E, Zhang M, Dai X, Zhang X, Wang S, Zhang J, Jia W, Zen K, Vidal-Puig A, Jiang X, Zhang CY. Pancreatic ß cells control glucose homeostasis via the secretion of exosomal miR-29 family.J Extracell Vesicles. 2021 Jan;10(3):e12055. doi: 10.1002/jev2.12055. Epub 2021 Jan 21. PMID: 33520119 Free PMC article. |
| Start Year | 2018 |
| Description | PGCs and Bone biology |
| Organisation | National Center for Geriatrics and Gerontology (NCGG) |
| Department | Department of Bone and Joint Disease |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | ongoing intellectual and experimental collaboration |
| Collaborator Contribution | access to facilities and expertise not otherwise available |
| Impact | PMID:19252502 |
| Start Year | 2007 |
| Description | PGCs and RIP140 |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | ongoing intellectual and experimental collaboration |
| Collaborator Contribution | access to facilities and expertise not otherwise available |
| Impact | none as yet |
| Start Year | 2007 |
| Description | PGCs in liver. |
| Organisation | University of Bari |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | ongoing intellectual and experimental collaboration |
| Collaborator Contribution | access to facilities and expertise not otherwise available |
| Impact | no tangible outputs as yet |
| Start Year | 2008 |
| Description | PPAR? and myocardial fibrosis |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | ongoing intellectual and experimental collaboration |
| Collaborator Contribution | access to facilities and expertise not otherwise available |
| Impact | PMID:19395708 |
| Start Year | 2007 |
| Description | PPARgamma2 and asthma |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | ongoing intellectual and experimental collaboration |
| Collaborator Contribution | access to facilities and expertise not otherwise available |
| Impact | collaboration started in 2009. There are tangible outcomes to report as yet |
| Start Year | 2007 |
| Description | Univerisdad de Barcelona- |
| Organisation | University of Barcelona |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Provide genetically modified murine models and technological support for phenotyping |
| Collaborator Contribution | Specific knowledge in the analysis of CPT1 mutants. This is a very specific type of specialised knowledge that provides us with competitive advantage |
| Impact | 1. Allostatic hypermetabolic response in PGC1a/ß heterozygote mouse despite mitochondrial defects. Rodriguez-Cuenca S, Lelliot CJ, Campbell M, Peddinti G, Martinez-Uña M, Ingvorsen C, Dias AR, Relat J, Mora S, Hyötyläinen T, Zorzano A, Orešic M, Bjursell M, Bohlooly-Y M, Lindén D, Vidal-Puig A. FASEB J. 2021 Sep;35(9):e21752. doi: 10.1096/fj.202100262RR. PMID: 34369602 2. P465L-PPAR? mutation confers partial resistance to the hypolipidaemic action of fibrates. Rodriguez-Cuenca S, Carobbio S, Barceló-Coblijn G, Prieur X, Relat J, Amat R, Campbell M, Dias AR, Bahri M, Gray SL, Vidal-Puig A. Diabetes Obes Metab. 2018 Oct;20(10):2339-2350. doi: 10.1111/dom.13370. Epub 2018 Jun 27. PMID: 29790245 Free PMC Article Similar articles Select item 26584636 Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A, Bujo H. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951. PMID: 26584636 Free PMC Article Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function. Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A. Diabetes. 2015 Apr;64(4):1180-92. doi: 10.2337/db14-0359. Epub 2014 Oct 28. PMID: 25352638 Free Article Trends Pharmacol Sci. 2013 Jun;34(6):347-55. doi: 10.1016/j.tips.2013.04.004. Epub 2013 May 3. Pharmacological strategies for targeting BAT thermogenesis. Whittle A1, Relat-Pardo J, Vidal-Puig A. |
| Start Year | 2018 |
| Description | WNT signaling and adipogenesis |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | ongoing intellectual and experimental collaboration |
| Collaborator Contribution | access to facilities and expertise not otherwise available |
| Impact | PMID: 20514047, 19772894, 19073771, 19008118 , 18445670 |
| Start Year | 2007 |
| Description | amylin corp |
| Organisation | Amylin Pharmaceuticals |
| Country | United States |
| Sector | Private |
| PI Contribution | identification of suitable patients |
| Collaborator Contribution | provision of recombinant leptin for human use |
| Impact | clinical benefits for patients. to be reported |
| Description | mitochondrial biogenesis |
| Organisation | AstraZeneca |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | ongoing intellectual and experimental collaboration |
| Collaborator Contribution | collaborative discussions |
| Impact | PMID: 20802499, 19536672, 19252502, 18974884, 18460330, |
| Start Year | 2007 |
| Description | studies on the identification of biomarkers |
| Organisation | Pfizer Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | development of biomarkers of FTO activity |
| Collaborator Contribution | scientific discussions |
| Impact | novel informationb re FTO |
| Start Year | 2008 |
| Description | systems biology/lipidomics |
| Organisation | VTT Technical Research Centre of Finland Ltd |
| Country | Finland |
| Sector | Academic/University |
| PI Contribution | expertise in experimental physiology |
| Collaborator Contribution | systems biology, bioinformatics/lipidomics analyses and input |
| Impact | PMID 20802499, 20514047, 19841237, 19341506, 18951641, 18213405 |
| Description | Bavarian Alps, Germany. 25th-27th September 2019. AMPro Summer School for PhD Students & Postdocs. Aging and Metabolic Programming. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Undergraduate students |
| Results and Impact | Bavarian Alps, Germany. 25th-27th September 2019. AMPro Summer School for PhD Students & Postdocs. Aging and Metabolic Programming. PhD programme related to the German Centre of Cancer where I serve as SAAB |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://ampro.helmholtz-muenchen.de/news-events/past-events/ampro-summer-school-2019/index.html |
| Description | Bilbao, Spain. 1st March 2017. Seminar at Biofisika, Basque Centre for Biophysics. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Bilbao, Spain. 1st March 2017. Seminar at Biofisika, Basque Centre for Biophysics. Lecture. Networking with engineers. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://biofisika.org/ |
| Description | Boston, USA. 11th May 2018. "Adventures in Metabolism" Symposium at Harvard Medical School. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Boston, USA. 11th May 2018. "Adventures in Metabolism" Symposium at Harvard Medical School. Lecture related to the role of Brown fat in metabolism. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.evensi.us/adventures-metabolism-symposium-celebrate-jeffrey-flier-70th-birthday/25406324... |
| Description | Keystone Symposia on Diabetes/Obesity and Adipose Tissue Biology. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Keystone Conference Lecture. Colorado, USA. 22nd - 27th January 2017. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://healthdocbox.com/amp/69735120-Diabetes/Diabetes-january-22-26-2017-keystone-conference-center... |
| Description | Mexico. 13th-14th February 2019. Nutrition Forum 2019 Danone Institute of Mexico. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on obesity and nutrition |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.danoneinstitute.org/nutrition-health/local-initiatives |
| Description | Naples, Italy. 28th May 2018. Seminar at The Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" of the National Research Council (CNR). |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Naples, Italy. 28th May 2018. Seminar at The Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" of the National Research Council (CNR). Lecture on the Adipose tissue expandability, lipotoxicity and metabolic syndrome. |
| Year(s) Of Engagement Activity | 2018 |
| Description | World Forum on Scientific & Technological Innovation in London. Looking for solutions to the emerging epidemic of ageing related health problems in China |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Highlights from the World Forum on Scientific & Technological Innovation in London. Looking for solutions to the emerging epidemic of ageing related health problems in China |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.linkedin.com/in/toni-vidal-puig-md-phd-frcp-fmedsci-emba-43804113/detail/recent-activity... |
| Description | Örebro/Sweden. 26th-28th August 2018. Nordic Metabolomics Conference. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Örebro/Sweden. 26th-28th August 2018. Nordic Metabolomics Conference. Role of lipidomics in metabolic research Opening keynote lecture Antonio Vidal-Puig (University of Cambridge, UK) "Adipose tissue expandability, lipotoxicity and the metabolic syndrome" |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.oru.se/english/about-us/conferences/nordic-metabolomics-conference/program/ |
| Description | 1. London, UK. 10th -11th February 2020. 3rd Global nonalcoholic steatohepatitis (NASH) Congress and co-located 1st Metabolic Syndrome, Diabetes and nonalcoholic fatty liver disease (NAFLD) Congress London. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | 1. London, UK. 10th -11th February 2020. 3rd Global nonalcoholic steatohepatitis (NASH) Congress and co-located 1st Metabolic Syndrome, Diabetes and nonalcoholic fatty liver disease (NAFLD) Congress London. Key meeting to engage with industry. |
| Year(s) Of Engagement Activity | 2020 |
| URL | http://www.global-engage.com/event/nash/ |
| Description | 2. Cambridge, United Kingdom. 5th July 2019 Joint work shop by Cambridge University Nanjing Centre of Technology and Innovation, Institute Metabolic Science, University of Cambridge, Model Animals Research Centre (MARC), University of Nanjing. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Cambridge, United Kingdom. 5th July 2019 Joint work shop by Cambridge University Nanjing Centre of Technology and Innovation, Institute Metabolic Science, University of Cambridge, Model Animals Research Centre (MARC), University of Nanjing. Meeting and networking event with colleagues from Cambridge and Nanjing to develop collaborative network |
| Year(s) Of Engagement Activity | 2019 |
| Description | 2nd Metabolomics Sardinian Scientific School |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 2nd Metabolomics Sardinian Scientific School was aimed at post-grad students new to the field of metabolomics. We gave seminars and workshops in various tools and techniques in metabolomics. |
| Year(s) Of Engagement Activity | 2016 |
| Description | 4. Bradford, UK. 1st December 2018. SRUK Seminar (Society of Spanish Researchers in the UK). |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | 4. Bradford, UK. 1st December 2018. SRUK Seminar (Society of Spanish Researchers in the UK). |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.eventbrite.co.uk/e/v-christmas-seminar-science-of-healthy-diet-sports-wellbeing-tickets-... |
| Description | 5. Valencia, Spain. 13th-15th November 2019 Spain Minisymposium Centro de Investigación Príncipe Felipe (CIPF). Longevity world forum, "Preclinical Models in Ageing and Metabolism Research" |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | 5. Valencia, Spain. 13th-15th November 2019 Spain Minisymposium Centro de Investigación Príncipe Felipe (CIPF). Longevity world forum, "Preclinical Models in Ageing and Metabolism Research" Global forum related to Ageing from a socio scientific and multicultural perspective. Open to lay public and highly advertised. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.longevityworldforum.com/tag/aging-2/ |
| Description | 6. Colorado, USA. 31st March - 5th April 2019. Keystone Symposia on Lipidomics and Functional Metabolic Pathways in Disease. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Colorado, USA. 31st March - 5th April 2019. Keystone Symposia on Lipidomics and Functional Metabolic Pathways in Disease. Conference at Keystone related to lipidomic analysis in the context of lipotoxicity |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://tks.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1595 |
| Description | 6. Sheffield, UK. 10th-11th September 2018. The British Society for Cardiovascular Research Autumn Meeting 'Inflammation and repair'. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | 6. Sheffield, UK. 10th-11th September 2018. The British Society for Cardiovascular Research Autumn Meeting 'Inflammation and repair'. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://bscr.org/event/bscr-autumn-meeting-2018-inflammation-and-repair/ |
| Description | Advances in obesity |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Health professionals |
| Results and Impact | Invited lecture at the RCPath annual conference Raising awareness in the research area for professionals |
| Year(s) Of Engagement Activity | 2006 |
| Description | Amsterdam, Netherlands. 5th-6th November 2019. Maternal obesity and pre-eclampsia |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Amsterdam, Netherlands. 5th-6th November 2019. Maternal obesity and pre-eclampsia. This was a conference organised by Biochemical Society where I gave the closing lecture as part of being awardee of the Sir Philip Randle Lecture, Biochemical Society |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://biochemistry.org/grants-and-awards/awards/the-sir-philip-randle-lecture/ |
| Description | BA Festival of Science |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Speaker 'Fat of the land or land of the fat?' session increased awareness of both environmental and genetic causes of obesity and the desire to eat |
| Year(s) Of Engagement Activity | 2008 |
| Description | BAT in Granada |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Interested in Brown Adipose Tissue? Can't miss this Symposium! https://finut-en.congressus.es/symposiumbat/index @ibsGRANADA @CIBER_OBN @TVPLab @FIBAO @CanalUGR @finutibero |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://twitter.com/ruizruizjonatan/status/1024216467729010688?s=12 |
| Description | Basel, Switzerland. 11th-14th September 2018. EMBO at Basel Life. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 2. Basel, Switzerland. 11th-14th September 2018. EMBO at Basel Life. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.basellife.org/basel-life-2018.html |
| Description | Bilbao, Spain. 8th June 2018. Seminar at Biogune. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 7. Bilbao, Spain. 8th June 2018. Seminar at Biogune. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://twitter.com/CICbioGUNE |
| Description | Cadiz, Spain. 8th-11th April 2019. EMBO "Organ Crosstalk in Energy Balance and Metabolic Disease". |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 10. Cadiz, Spain. 8th-11th April 2019. EMBO "Organ Crosstalk in Energy Balance and Metabolic Disease". 3 day conference organised by EMBO to discuss interorgan communication and its relevance in metabolic disease. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://meetings.embo.org/event/19-organ-crosstalk |
| Description | Café Scientifique |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | gave presentation at Cambridge meeting of Café Scientifique 'Are your genes to blame when your jeans don't fit?' provoked debate between audience members and speaker |
| Year(s) Of Engagement Activity | 2010 |
| Description | Cambridge Metabolic Network/Danish Diabetes Association Course for PhD Students. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | Course sponsored by NOVO foundation from Denmark, 35 PhD students from Cambridge and Denmark. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.danishdiabetesacademy.dk/events/lipid-metabolism-new-methods-and-translational-aspects |
| Description | Cambridge, United Kingdom. 2nd -4th July 2019 EAS Advanced Course in Cardiometabolic Phenotyping |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Cambridge, United Kingdom. 2nd -4th July 2019 EAS Advanced Course in Cardiometabolic Phenotyping Training hands on to develop expertise in cardiometabolic phenotyping |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.eas-society.org/events/EventDetails.aspx?id=1211946 |
| Description | Doha, Qatar. 4th-6th December 2019 Anti-Doping Laboratory Qatar for the 7th Junior Symposium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | This activity was related to a PhD annual conference ree=lated to the course for women in Qatar as part of the programme coordinated by Univeristy College of London, Bristol and Groningen. |
| Year(s) Of Engagement Activity | 2019 |
| Description | EPOS2019 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Wehosted the 2020 Horizon EPoS project Steering commitee meeting at St Catherine College in Cambridge to discuss the latest results on the pathogenesis, diagnostic and treatment of fatty liver and NASH. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.linkedin.com/in/toni-vidal-puig-md-phd-frcp-fmedsci-emba-43804113/detail/recent-activity... |
| Description | Farewell symposium for Henrik Mortensen, Copenhagen |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Festschrift to celebrate the career of a distinguished Danish Paediatric Endocrinologist |
| Year(s) Of Engagement Activity | 2018 |
| Description | Genetic basis of obesity |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | lecture presentation to the 41st Annual meeting of the European Society for Clinical Investigation Raised awareness of our work and the area for scientists and clinicians |
| Year(s) Of Engagement Activity | 2007 |
| Description | Genetic causes of obesity |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Health professionals |
| Results and Impact | Berzelius symposium, Umea improved knowledge of health professionals regarding advances in obesity |
| Year(s) Of Engagement Activity | 2008 |
| Description | Genetic contributions to type 1 diabetes (The Endocrine Society, USA) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited to lecture in the USA by the Endocrine Society - a symposium concerning studies of early prediction and prevention of type 1 diabetes. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.endocrine.org |
| Description | Genetics of Human Obesity |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Invited presentation at the 8th European Congress of Endocrinology. Raised awareness of our studies and the genetic basis of obesity among endocrinologists |
| Year(s) Of Engagement Activity | 2006 |
| Description | Genetics of obesity and diabetes |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Invited presentation to the 9th WHO/IDF Seminar on the Epidemiology and Public Health Aspects of Diabetes Mellitus. The international audience included epidemiologists and public health practitioners Raised awareness of our work and the area in general to an international public health audience |
| Year(s) Of Engagement Activity | 2006 |
| Description | Genetics of obesity: food for thought |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | presentation of our work to a public audience at the Dana Centre, London Raised awareness of the genetic basis of obesity to a general audience |
| Year(s) Of Engagement Activity | 2006 |
| Description | Gothenburg, Sweden. 5th October 2018. Wallenberg Lab 30th Anniversary Symposium. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Gothenburg, Sweden. 5th October 2018. Wallenberg Lab 30th Anniversary Symposium. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Human obesity & insulin resistance: lessons from the extremes |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Health professionals |
| Results and Impact | presentation as the Wilkins Visiting Professor for Evan Days improved knowledge of health professionals regarding advances in obesity |
| Year(s) Of Engagement Activity | 2008 |
| Description | Human obesity: science versus stigma |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Gave the Annual Wade lecture at the University of Southampton School of Medicine's foundation. This lecture is aimed at enhancing public understanding of medicine and science improved public understanding of the genetic factors that underlie obesity |
| Year(s) Of Engagement Activity | 2007 |
| Description | Human obesity: science vs stigma |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Presented the 'In praise of medicine' public leture, Erasmus University, The Netherlands Raised awareness of genetic determinants of obesity and overweight |
| Year(s) Of Engagement Activity | 2007 |
| Description | INNODIA - what do we aim for and how to find the needle (ISPAD) International Society for Pediatric and Adolecent Diabetes |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Lecture to an international group describing how a new EU programme (INNODIA [co-lead David Dunger]) may impact on type 1 diabetes research |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.innodia.eu/ |
| Description | Insulin-like growth factor 1 and preterm infants (British Association of Perinatal Medicine) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited lecture to a professional group of neonatalogists (nurses.doctors) concerning studies of IGF-1 in preterm infants. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Introduction to the Cambridge Baby Growth Study (BioFN Kick off meeting) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | start up meeting to plan a new European Research grant. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Lessons from human phenotypes of obesity and insulin resistance |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Invited presentation to specialist academic researchers and clinicians at the 51st meeting of the Japan Diabetes Society Raised awareness of our work to an internation audience |
| Year(s) Of Engagement Activity | 2008 |
| Description | Lessons from studies of the genetics of syndromic forms of metabolic traits |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Invited lecture at the EASD Genomics of hyperglycaemia International Symposium, Denmark Raised awareness of the genetic basis of obesity and type 2 diabetes for health professionals |
| Year(s) Of Engagement Activity | 2006 |
| Description | MIddle EaSt obesity |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Professors Toni Vidal-Puig MD PhD FRCP FMedSci EMBA and Meis Moukayed have honoured us by writing the fascinating article, People with obesity: Their heroic battle to defeat their genes in a hostile hypercaloric sedentary environment. The professors explain why more than 50 human genes, the environment and lifestyle culture all contribute to why it is not so easy as the doctor telling the patient to lose weight. In addition to looking at the 'why' of obesity, |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.middleeastmedicalportal.com/product/november-december-2018/ |
| Description | Madrid, Spain. 20th-21 November 2019 Scientific meeting of the Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Madrid, Spain. 20th-21 November 2019 Scientific meeting of the Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN) This meeting brings all teh community of investigators on the field of obesity in Spain. It is an excellent place to identify talent. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.ciberobn.es/en |
| Description | Madrid, Spain. 22nd November 2018. CIBEROBN Annual Symposium. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Madrid, Spain. 22nd November 2018. CIBEROBN Annual Symposium. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.ciberobn.es/en |
| Description | Madrid, Spain. 31st May 2019. 6th Symposium on Biomedical Research "Advances & Perspectives in Molecular Endocrinology" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | 9. Madrid, Spain. 31st May 2019. 6th Symposium on Biomedical Research "Advances & Perspectives in Molecular Endocrinology" This was a high level scientific event organised by CSIC in Madrid attended predominantly by experts in endocrinology |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://eventos.uam.es/28633/detail/6th-symposium-on-biomedical-reserch-advances-and-perspectives-in... |
| Description | Mature student lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Gave a presentation to mature students at the University of Cambridge, organised by the Cambridge Admissions Office unknown as yet |
| Year(s) Of Engagement Activity | 2010 |
| Description | Mente y Cerebro article |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Article entitled 'Claves para entender la pandemia de obesidad' in the Spanish language edition of the popular magazine Scientific American (authors, Tan and Vidal-Puig) Raised awarenes and interest in scientific studies of body weight regulation |
| Year(s) Of Engagement Activity | 2007 |
| Description | Mexico Instituto Zubiran de Nutricion |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | Seminar evaluation PhD students projects |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.linkedin.com/in/toni-vidal-puig-md-phd-frcp-fmedsci-emba-43804113/detail/recent-activity... |
| Description | Nanjing, China. 19th-25th May 2019. The Sino-UK Cardiovascular disease symposium. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 5. Nanjing, China. 19th-25th May 2019. The Sino-UK Cardiovascular disease symposium. Meeting in Nanjing with faculty from Nanjing Medical School for collaborative research and networking |
| Year(s) Of Engagement Activity | 2019 |
| Description | Nephrology - what have we learnt from AdDIT (ADOLESCENT TYPE 1 DIABETES CARDIO-RENAL INTERVENTION TRIAL)National Paediatric and Adolescent Diabetes Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | update on the progress of AdDIT study |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.addit-trial.org/ |
| Description | Oxford, UK. 18th January 2019. Seminar in Department of Physiology, Anatomy & Genetics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Undergraduate students |
| Results and Impact | Oxford, UK. 18th January 2019. Seminar in Department of Physiology, Anatomy & Genetics Date: 18 January 2019, 13:00 (Friday, 1st week, Hilary 2019) Venue: Sherrington Building off Parks Road OX1 3PT See location on maps.ox Details: Large Lecture Theatre Speaker: Professor Antonio Vidal-Puig (University of Cambridge) Organising department: Department of Physiology, Anatomy and Genetics (DPAG) Organiser contact email address: ana.domingos@dpag.ox.ac.uk Host: Dr Ana Domingos (University of Oxford, DPAG) Part of: DPAG Head of Department Seminar Series Topics: Inflammation, Diabetes, Adipose tissues, Metabolic syndrome, Obesity |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://new.talks.ox.ac.uk/talks/id/f6ae26ed-6a85-4ea6-8236-0be648588540/ |
| Description | Paris, France. 11th-15th April 2018. EASL International Liver Congress. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at the Paris, France. 11th-15th April 2018. EASL International Liver Congress focused on the pathogenesis of fatty liver and the effect of Lipotoxicty |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://easl.eu/discover/events/detail/2018/the-international-liver-congress-2018 |
| Description | Patient Participation and Involvement within CPRU National Childrens Bureau, London |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Study participants or study members |
| Results and Impact | about 30 children were involved in workshop activities to discuss a research project - patient and public involvement |
| Year(s) Of Engagement Activity | 2018 |
| Description | President, British Thyroid Association |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Appointed as President of the British Thyroid Association 2018-2021 |
| Year(s) Of Engagement Activity | 2018,2019,2020,2021 |
| URL | http://www.british-thyroid-association.org/sandbox/bta2016/bta_newsletter_january_2018.pdf |
| Description | Public debate |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | spoke at Public debate exploring the causes, solutions and implications of the 'obesity epidemic'' increased awareness of both environmental and genetic causes of obesity and the desire to eat |
| Year(s) Of Engagement Activity | 2008 |
| Description | Royal Swedish Academy of Sciences, Journal of Internal Medicine - Key Symposium "Metabolic complications of obesity" |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Organisation of symposia with 150 attendants, 28 speakers from EU, USA, JAPAN, CHINA. Top symposium supported by the Swedish Academy of Sciences and the Journal of Internal Medicine. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.mrl.ims.cam.ac.uk/event/metabolic-complications-obesity/ |
| Description | SOR Academy of Medical Sciences |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Raised awareness of research and IMS None |
| Year(s) Of Engagement Activity | 2013 |
| Description | SOR Award Lecture for Zulch prize |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Raised awareness of research and IMS Prestigious award of Zulch prize |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.mpg.de/8406171/zuelch_award_2014_orahilly_friedman |
| Description | SOR BBC TV and Radio Interviews |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Raise awareness of research and IMS to the public None |
| Year(s) Of Engagement Activity | 2013 |
| Description | SOR CSAR talk, University of Cambridge |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Gave talk at Cambridge Society for the Application of Research on "Human Metabolic Disease, Lessons from the Extremes" Raised awareness of research and of IMS |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.csar.org.uk/index.html |
| Description | SOR CSaP |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Member of Centre for Science & Policy Executive Committee, University of Cambridge None |
| Year(s) Of Engagement Activity | 2013,2014 |
| Description | SOR Doha talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Invited guest speaker at Academic Health System lecture series at Hamad Medical Corporation, Doha, Qatar Raise awareness of research and IMS |
| Year(s) Of Engagement Activity | 2014 |
| Description | SOR Dublin Science Gallery |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited speaker at Trinity College Dublin Science Gallery as part of exhibition and 'Lab in the Gallery' FAT LAB. The goal of FAT LAB is to initiate a widespread re-evaluation of the perception of fat by inviting visitors to the gallery to participate in real research experiments and by creating a series of talks and events to engage our target audience of 15-25 year olds. Raise awareness of research and IMS |
| Year(s) Of Engagement Activity | 2014 |
| URL | https://dublin.sciencegallery.com/video/2014/07/sciencefatstephenorahillyanddonaloshea |
| Description | SOR JCI Interview-Conversations with Giants in Medicine |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Raised awareness of research and IMS None |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www.jci.org/videos/cgms |
| Description | SOR MRC Centenary Open Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Raised awareness of research and IMS among public None |
| Year(s) Of Engagement Activity | 2013 |
| Description | SOR MedSOC talk, Cambridge |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker at MedSOC talk, University of Cambridge Raise awareness of research and of IMS |
| Year(s) Of Engagement Activity | 2014 |
| Description | SOR Naked Scientist Question of the Week |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Raised awareness of research and IMS to public None |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www.thenakedscientists.com/HTML/podcasts/qotw/show/20130307/ |
| Description | SOR National Health and Medical Research Council (NHMRC) CEO Obesity Roundtable |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Participated in roundtable discussion with members of Australian Government National Health and MRC and others Raise awareness of research and IMS |
| Year(s) Of Engagement Activity | 2014 |
| Description | SOR Pharmacology tea club talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited to give University of Cambridge Department of Pharmacology tea club talk Raise awareness of research and of IMS |
| Year(s) Of Engagement Activity | 2014 |
| Description | SOR RTE interviews |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Raised awareness of research and IMS to the public None |
| Year(s) Of Engagement Activity | 2013 |
| Description | SOR Research Lecture Karolinska Institute, Stockholm |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Raised awareness of research and IMS among peers None |
| Year(s) Of Engagement Activity | 2013 |
| Description | SOR SAC Conway |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Scientific Advisory Board None |
| Year(s) Of Engagement Activity | 2013 |
| Description | SOR SAC Crick Institute |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Scientific Advisory Board None |
| Year(s) Of Engagement Activity | 2013 |
| Description | SOR SAC Fondation Leducq |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Scientific Advisory Committee None |
| Year(s) Of Engagement Activity | 2013,2014 |
| Description | SOR UCD MGA presentation lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Gave presentation when awarded Medical Graduates Association Distinguished Graduate Award from University College Dublin for 2014 Raised awareness of research and IMS |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.ucd.ie/medicine/ourcommunity/ouralumni/ |
| Description | SOR University of Bristol talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Invited speaker at University of Bristol MRC IEU Seminar Series Raise awareness of research and IMS |
| Year(s) Of Engagement Activity | 2014 |
| Description | SOR University of Leuven |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Gave talk at University of Leuven, Belgium in seminar series for high profile scientists aimed at broad audience Raised awareness of research and IMS |
| Year(s) Of Engagement Activity | 2014 |
| Description | SOR University of Manchester talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker at University of Manchester at Faculty's Life Science 'Leaders in Science' Lecture Series Raise awareness of research and IMS |
| Year(s) Of Engagement Activity | 2014 |
| Description | SOR University of the Third Age, Cambridge |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited to give talk at University of the Third Age in Cambridge Raise awareness of research and IMS |
| Year(s) Of Engagement Activity | 2014 |
| Description | Schools Masterclasses series 2009 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | lectured to GCSE students in the Schools Masterclasses series, in which GCSE students are invited to Cambridge for a day of talks and tours. improved students awareness of recent advances in obestity research and in the genetic basis of common obesity. Was asked by an audience member to speak at another school event in Moulton College |
| Year(s) Of Engagement Activity | 2009,2010,2011,2012 |
| Description | Science News Study inMice suggests drug to turn fat brown could help fight obesity |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | https://www.sciencedaily.com/releases/2018/11/181126123416.htm Study in mice suggests drug to turn fat 'brown' could help fight obesity Date:November 26, 2018 Source:University of Cambridge Summary:Our bodies contain two types of fat: white fat and brown fat. While white fat stores calories, brown fat burns energy and could help us lose weight. Now, scientists have found a way of making the white fat 'browner' and increasing the efficiency of brown fat. While their study was carried out in mice, they hope that this finding will translate into humans and provide a potential new drug to help fight obesity. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.sciencedaily.com/releases/2018/11/181126123416.htm |
| Description | Singapore2019 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | University of Cambridge meets with our colleagues from the National University of Singapore to strenght our collaborative cardiovascular research network. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Talk: Genetic and Lipidomic Associations with pregnancy and newborn outcomes in the Cambridge Baby Growth Study |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | update on academic progress several aspects of the Cambridge Baby Growth Study. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://paediatrics.medschl.cam.ac.uk/research/clinical-trials/cambridge-baby-growth-study/ |
| Description | Talk:Coordinated appproaches to the identification of clinical useful biomarkers |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Research In progress seminar series: update on recent work with Cambridge Baby Growth Study and the AdDIT study. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://paediatrics.medschl.cam.ac.uk/research/clinical-trials/cambridge-baby-growth-study/ |
| Description | The Biochemist article |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Article entitled 'The metabolic sydrome - where do we go from here?' in the popular magazine The Biochemist. difficult to assess at present |
| Year(s) Of Engagement Activity | 2009 |
| Description | The genetic basis of obesity |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Invited lecture o the International Congress of Endocrinology, Sydney, Australia Raised awareness of our research group and the area for professionals |
| Year(s) Of Engagement Activity | 2006 |
| Description | Tye 2 Diabetes; Atherapeutic avenue is emerging |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Date:December 5, 2018 Source:INSERM (Institut national de la santé et de la recherche médicale) Summary:Restoring the action of insulin is one of the keys to fighting type 2 diabetes. Researchers are developing a therapeutic strategy that uses the properties of an enzyme (hormone-sensitive lipase) which, when stimulating fatty-acid synthesis in the fat cells, has a beneficial effect on insulin action. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.sciencedaily.com/releases/2018/12/181205134014.htm |
| Description | Update on nephropathy - when do we treat (American Diabetes Association) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Lecture at the Annual Meeting of the American Diabetes Association reporting the results of a large international study AdDIT (ADOLESCENT TYPE 1 DIABETES CARDIO-RENAL INTERVENTION TRIAL) |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.addit-trial.org/ |
| Description | Valencia, Spain. 17th - 18th October 2019. Liver Investigation: Testing Marker Utility in Steatohepatitis (litmus) 3rd General Assembly. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Valencia, Spain. 17th - 18th October 2019. Liver Investigation: Testing Marker Utility in Steatohepatitis (litmus) 3rd General Assembly. This was the annual meeting of the IMI Litmus where we are aiming to identify biomarkers of NASH. My group leads the preclinical programme and presented advances in cross species validation of biomarkers |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://litmus-project.eu/ |
| Description | WT vacation students |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Hosted two 10 week laboratory project for undergraduate students students have gone on to higher degrees in life sciences |
| Year(s) Of Engagement Activity | 2010,2011 |
| Description | Workshop advisor |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Expert advisor at the Wellcome Trust workshop for Public Engagement Society Awards 'Eating' was later consulted by several groups preparing to apply to the Engaging Science Society Awards programme which aim to engage people with developments in biomedical science on a regional or national scale. |
| Year(s) Of Engagement Activity | 2009 |
| Description | YouTube video showing success in identifying and treating a patient with a rare thyroid disorder via the 100,000 Genomes Project |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | YouTube video showing success in identifying and treating a patient with a rare thyroid disorder via the 100,000 Genomes Project |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.youtube.com/watch?v=OONvM0CX03I |
| Description | https://en.wikipedia.org/wiki/Antonio_Vidal-Puig |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | https://en.wikipedia.org/wiki/Antonio_Vidal-Puig |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://en.wikipedia.org/wiki/Antonio_Vidal-Puig |
| Description | https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283 |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283 November 27, 2018 Could this be a solution for the obesity crisis? Samuel Virtue, University of Cambridge; Antonio Vidal-Puig, University of Cambridge, and Vanessa Pellegrinelli, University of Cambridge Scientists manage to boost brown fat in mice with a molecule called BMP8b. Could this be the future for treating obesity? |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283 |
| Description | work experience students |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Hosted several work experience placements for 6th form students in the laboratory Increased awareness of sceintific methods to enthusiastic 6-form students, and encouraged their ambitions for a scientific career. The experience caused 1 student to study biology at A level |
| Year(s) Of Engagement Activity | 2007,2008,2009 |
| Description | work experience, 6th form student |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | hosted work experience placement for local 6th form student Student loved their stay on the lab and went on to study biology at A level |
| Year(s) Of Engagement Activity | 2009 |