Translational Research Pilot Scheme

Lead Research Organisation: King's College London
Department Name: Applied Biomedical Research

Abstract

The UK is very strong in basic biomedical research,but less good in translating the results of this basic research into new information, products or devices which can be used by the pharmaceutical industry to produce new medicines.This pilot scheme tests the idea that skilled and experienced translators who work closely with both scientists and doctors can effectively facilitate this translation process.

Technical Summary

Effective development of basic science findings to proof of concept and preclinical stages of development is notably difficult to achieve.This pilot scheme aims to test the hypothesis that a skilled and experienced translator working alongside basic scientists can, if appropriately resourced, facilitate this translation process.The pilot will run for 3 years and the outcome will be independently evaluated by MRC.

Publications

10 25 50
 
Description Importance of HLA epitope matching for transplantation
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Devolved DPFS Portfolio
Amount £2,000,000 (GBP)
Funding ID G0900865 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2009 
End 03/2011
 
Title Epitope PCR 
Description PCR methodology for HLA epitope matching 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact Influenced status of HLA epitope matching and progress towards naming of epitopes 
 
Title IgE-receptor inhibitors 
Description Inhibitors of IgE-receptor interactions 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact The compounds are under evaluation by Pharma companies for potential licencing 
 
Title IgE-receptor inhibitors 
Description Inhibitors of IgE-receptor interactions have been identified. These are currently being evaluated by Pharma companies for potential licencing 
Type Therapeutic Intervention - Drug
Current Stage Of Development Initial development
Year Development Stage Completed 2011
Development Status Actively seeking support
Impact Small molecule inhibitors of IgE action potentially suitable for clinical development