NeuroPsyGrid: towards an ontology and multi-centre brain imaging for early psychosis.
Lead Research Organisation:
University of Edinburgh
Department Name: Unlisted
Abstract
This collaboration brings together two existing MRC-funded projects, to help develop national and international collaborations in psychosis research.
There are two main problems to be overcome in integrating multiple data sets for multi-centre studies. The first is to know what is in each data set and what it is intended for. This is annotation or meta data - data about data. The second is to specify precisely what is meant both by the data itself and the meta data - which is the business of ontologies .
We are working together towards a database, common metadata and a simple ontology for psychosis. We will then test this system as a method of combining data from existing studies to answer clinically relevant questions.
We are also studying structural and functional brain imaging reproducibility within and between five research centres.
These developments will put us and other mental health researchers in a better position to conduct large multi-centre studies of earlier detection methods, more effective treatments and possibly even preventative interventions in people at high risk of or in the early stages of psychosis.
There are two main problems to be overcome in integrating multiple data sets for multi-centre studies. The first is to know what is in each data set and what it is intended for. This is annotation or meta data - data about data. The second is to specify precisely what is meant both by the data itself and the meta data - which is the business of ontologies .
We are working together towards a database, common metadata and a simple ontology for psychosis. We will then test this system as a method of combining data from existing studies to answer clinically relevant questions.
We are also studying structural and functional brain imaging reproducibility within and between five research centres.
These developments will put us and other mental health researchers in a better position to conduct large multi-centre studies of earlier detection methods, more effective treatments and possibly even preventative interventions in people at high risk of or in the early stages of psychosis.
Technical Summary
This collaboration would enhance two existing MRC-funded Grid projects by working together to help develop national and international e-Science collaborations in psychosis research. Both projects are concerned with the collection of multi-centre data for psychosis research. Yet to link together and interpret these datasets requires a common consensus on the way the data objects are organised ? the metadata ? and on the termnology used to describe and annotate their contents ? an ontology. Thus, we aim to harmonise our joint work towards a common database, a shared metadata model and a simple ontology for psychosis. In particular, by adopting a novel focus on changes in clinical and biological variables over time, in the few years before and after diagnosis, we will be able to test the utility of these integrated clinical, behavioural and imaging data as an indexing and discovery aid to answering clinically relevant questions. We will also study structural and functional brain imaging reproducibility within and between three centres from PsyGrid and two centres from NeuroGrid. We will ensure that these data acquisition, storage and access arrangements are compatible with other major national and international initiatives. Developing this infrastructure and piloting these processes will put us and other mental health researchers in a better position to conduct large multi-centre clinical and neuro-imaging studies of earlier detection methods, more effective treatments and finally even preventative interventions in people at high risk of or in the early stages of psychosis.
Publications


Kola J
(2010)
Towards an ontology for psychosis
in Cognitive Systems Research

Moorhead TW
(2009)
Prospective multi-centre Voxel Based Morphometry study employing scanner specific segmentations: procedure development using CaliBrain structural MRI data.
in BMC medical imaging

Suckling J
(2012)
The Neuro/PsyGRID calibration experiment: identifying sources of variance and bias in multicenter MRI studies.
in Human brain mapping

Suckling J
(2010)
Power calculations for multicenter imaging studies controlled by the false discovery rate.
in Human brain mapping
Description | RIN open science case studies |
Geographic Reach | National |
Policy Influence Type | Participation in a national consultation |
Impact | Addresses the importance of curating brain imaging and related data |
Description | Efficacy and Mechanism Evaluation |
Amount | £1,880,026 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 07/2011 |
End | 08/2015 |
Description | Heptares Therapeutics Ltd |
Amount | £528,093 (GBP) |
Organisation | P1vital Consortium |
Sector | Private |
Country | United Kingdom |
Start | |
End | 03/2017 |
Description | Lundbeck commercial/academic |
Amount | £237,068 (GBP) |
Organisation | P1vital Consortium |
Sector | Private |
Country | United Kingdom |
Start | 05/2012 |
End | 12/2013 |
Description | MRC Stratified Medicine scheme |
Amount | £3,800,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 02/2014 |
End | 01/2017 |
Description | P1Vital; Sunovion Ltd |
Amount | £450,000 (GBP) |
Organisation | P1vital Consortium |
Sector | Private |
Country | United Kingdom |
Start | 08/2014 |
End | 03/2016 |
Title | MRI brain scans |
Description | 12 people had sMRI, working memory fMRI, affect processing fMRI and resting state fMRI on twonoccasions each on five 3T MRI machines each |
Type Of Material | Database/Collection of Data/Biological Samples |
Provided To Others? | No |
Impact | This provides proof of concept that multi-centre MRI is practicable and such data can be combined. It also provides a resource for ongoing evaluation of different approaches to analysis and for power calculations for studies proposing to use these different approaches |
Description | ECNP Neuro-Imaging Network |
Organisation | European College of Neuropsychopharmacology (ECNP) |
Country | Netherlands |
Sector | Charity/Non Profit |
PI Contribution | We are in charge of harmonising brain images from multiple centres |
Collaborator Contribution | Provided organisational impetus to this collaboration across EuropeDatabase construction |
Impact | PMID: 19717283 |
Start Year | 2009 |
Description | ECNP Neuro-Imaging Network |
Organisation | King's College London |
Department | Institute of Psychiatry, Psychology & Neuroscience |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We are in charge of harmonising brain images from multiple centres |
Collaborator Contribution | Provided organisational impetus to this collaboration across EuropeDatabase construction |
Impact | PMID: 19717283 |
Start Year | 2009 |
Description | Minocycline for Schizophrenia research group |
Organisation | University of Manchester |
Department | School of Medicine Manchester |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We are regarded as having special expertise in longitudinal and multi-centre brain imaging |
Collaborator Contribution | Co-ordinated a grant application |
Impact | We have recieved grant funding from NIHE EME to do a RCT of Minocycline augmentation of standard treatment for schizophrenia |
Start Year | 2010 |
Title | An Ontology for Psychosis |
Description | A software package which can transalte between different clinical rating and interview schedules for psychosis |
IP Reference | |
Protection | Copyrighted (e.g. software) |
Year Protection Granted | 2009 |
Licensed | No |
Impact | Favourable user assessments |
Title | An ontology for psychosis |
Description | A software package which translates between various clinical ratings scales and interviews for psychotic symptoms and diagnosis |
Type | Diagnostic Tool - Non-Imaging |
Current Stage Of Development | Early clinical assessment |
Year Development Stage Completed | 2009 |
Development Status | On hold |
Impact | User assessments have been positive |
Title | Minocycline |
Description | Clinical trial of minocycline added to treatment as usual for early schizophrenia primary efficacy end point - improvement of negative symptoms over 12 months; primary mechanistic end point - prevention of grey matter loss using imaging in early psychosis. 207 patients recruited within 24 months to target and on time |
Type | Therapeutic Intervention - Drug |
Current Stage Of Development | Initial development |
Year Development Stage Completed | 2016 |
Development Status | Closed |
Clinical Trial? | Yes |
Impact | The results are being analysed |
URL | http://www.isrctn.com/ISRCTN49141214 |