NeuroPsyGrid: towards an ontology and multi-centre brain imaging for early psychosis.

Lead Research Organisation: University of Edinburgh
Department Name: Unlisted

Abstract

This collaboration brings together two existing MRC-funded projects, to help develop national and international collaborations in psychosis research.

There are two main problems to be overcome in integrating multiple data sets for multi-centre studies. The first is to know what is in each data set and what it is intended for. This is annotation or meta data - data about data. The second is to specify precisely what is meant both by the data itself and the meta data - which is the business of ontologies .

We are working together towards a database, common metadata and a simple ontology for psychosis. We will then test this system as a method of combining data from existing studies to answer clinically relevant questions.

We are also studying structural and functional brain imaging reproducibility within and between five research centres.

These developments will put us and other mental health researchers in a better position to conduct large multi-centre studies of earlier detection methods, more effective treatments and possibly even preventative interventions in people at high risk of or in the early stages of psychosis.

Technical Summary

This collaboration would enhance two existing MRC-funded Grid projects by working together to help develop national and international e-Science collaborations in psychosis research. Both projects are concerned with the collection of multi-centre data for psychosis research. Yet to link together and interpret these datasets requires a common consensus on the way the data objects are organised ? the metadata ? and on the termnology used to describe and annotate their contents ? an ontology. Thus, we aim to harmonise our joint work towards a common database, a shared metadata model and a simple ontology for psychosis. In particular, by adopting a novel focus on changes in clinical and biological variables over time, in the few years before and after diagnosis, we will be able to test the utility of these integrated clinical, behavioural and imaging data as an indexing and discovery aid to answering clinically relevant questions. We will also study structural and functional brain imaging reproducibility within and between three centres from PsyGrid and two centres from NeuroGrid. We will ensure that these data acquisition, storage and access arrangements are compatible with other major national and international initiatives. Developing this infrastructure and piloting these processes will put us and other mental health researchers in a better position to conduct large multi-centre clinical and neuro-imaging studies of earlier detection methods, more effective treatments and finally even preventative interventions in people at high risk of or in the early stages of psychosis.
 
Description RIN open science case studies
Geographic Reach National 
Policy Influence Type Participation in a national consultation
Impact Addresses the importance of curating brain imaging and related data
 
Description Efficacy and Mechanism Evaluation
Amount £1,880,026 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 08/2011 
End 08/2015
 
Description Heptares Therapeutics Ltd
Amount £528,093 (GBP)
Organisation P1vital Consortium 
Sector Private
Country United Kingdom
Start  
End 03/2017
 
Description Lundbeck commercial/academic
Amount £237,068 (GBP)
Organisation P1vital Consortium 
Sector Private
Country United Kingdom
Start 06/2012 
End 12/2013
 
Description MRC Stratified Medicine scheme
Amount £3,800,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 02/2014 
End 01/2017
 
Description P1Vital; Sunovion Ltd
Amount £450,000 (GBP)
Organisation P1vital Consortium 
Sector Private
Country United Kingdom
Start 09/2014 
End 03/2016
 
Title MRI brain scans 
Description 12 people had sMRI, working memory fMRI, affect processing fMRI and resting state fMRI on twonoccasions each on five 3T MRI machines each 
Type Of Material Database/Collection of Data/Biological Samples 
Provided To Others? No  
Impact This provides proof of concept that multi-centre MRI is practicable and such data can be combined. It also provides a resource for ongoing evaluation of different approaches to analysis and for power calculations for studies proposing to use these different approaches 
 
Description ECNP Neuro-Imaging Network 
Organisation European College of Neuropsychopharmacology (ECNP)
Country Netherlands 
Sector Charity/Non Profit 
PI Contribution We are in charge of harmonising brain images from multiple centres
Collaborator Contribution Provided organisational impetus to this collaboration across EuropeDatabase construction
Impact PMID: 19717283
Start Year 2009
 
Description ECNP Neuro-Imaging Network 
Organisation King's College London
Department Institute of Psychiatry, Psychology & Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution We are in charge of harmonising brain images from multiple centres
Collaborator Contribution Provided organisational impetus to this collaboration across EuropeDatabase construction
Impact PMID: 19717283
Start Year 2009
 
Description Minocycline for Schizophrenia research group 
Organisation University of Manchester
Department School of Medicine Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution We are regarded as having special expertise in longitudinal and multi-centre brain imaging
Collaborator Contribution Co-ordinated a grant application
Impact We have recieved grant funding from NIHE EME to do a RCT of Minocycline augmentation of standard treatment for schizophrenia
Start Year 2010
 
Title An Ontology for Psychosis 
Description A software package which can transalte between different clinical rating and interview schedules for psychosis 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2009
Licensed No
Impact Favourable user assessments
 
Title An ontology for psychosis 
Description A software package which translates between various clinical ratings scales and interviews for psychotic symptoms and diagnosis 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2009
Development Status On hold
Impact User assessments have been positive 
 
Title Minocycline 
Description Clinical trial of minocycline added to treatment as usual for early schizophrenia primary efficacy end point - improvement of negative symptoms over 12 months; primary mechanistic end point - prevention of grey matter loss using imaging in early psychosis. 207 patients recruited within 24 months to target and on time 
Type Therapeutic Intervention - Drug
Current Stage Of Development Initial development
Year Development Stage Completed 2016
Development Status Closed
Clinical Trial? Yes
Impact The results are being analysed 
URL http://www.isrctn.com/ISRCTN49141214