Vitamin D and health: genome-wide analysis and insights from Mendelian randomisation.

Lead Research Organisation: University College London
Department Name: Institute of Child Health

Abstract

Inadequate vitamin D intake has been implicated as a risk factor for many important diseases such as diabetes, cancer and cardiovascular diseases. However, much of the evidence for the health effects of vitamin D comes from observational studies, and conclusions based on these studies may be affected by methodological problems such as bias and confounding. In this study, we will use a novel approach based on genetic information (so-called Mendelian Randomisation) and our aim is to see if the associations between vitamin D and the risk of various diseases can be replicated. If replication is found, this would give further support for a causal association between vitamin D and the outcome of interest. We will use data from the nationwide 1958 British birth cohort, in which over 7000 participants have been followed-up over four decades and detailed information has been collected on genetic markers and a wide-range of health related factors, including vitamin D status, lifestyle, diet, and indicators of disease risk.

Technical Summary

Inadequate vitamin D intake has been implicated as a risk factor for diabetes, cancer and cardiovascular diseases. Much of the evidence for health effects comes from observational studies and may be affected by problems of bias and confounding. The use of vitamin D prophylaxis in intervention studies is limited by concerns of possible toxicity. We propose to carry out a genome-wide analysis on 25(OH)D in the British 1958 cohort study - the first such study in a general population. Further, after identification of genetic variants associated with vitamin D metabolism, we will proceed to apply a mendelian randomization approach to obtaining evidence as to the effects of vitamin D. In mendelian randomization, genetic variants are used as proxy markers for variations in environmentally modifiable exposures (here vitamin D intake and levels). If evidence for an association between vitamin D and disease risk (suggested by other types of studies) can be obtained using mendelian randomization, this would provide evidence for a causal relation. We will evaluate method limitations and the use multiple indicators (located in varying parts of the human genome) as a way of overcoming some of these problems. The key aim of the project is to provide information on an approach, which could provide a safe and cost-effective way of evaluating the influences of vitamin D on health.

Organisations

Publications

10 25 50

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Berry D (2011) Determinants of vitamin D status: focus on genetic variations. in Current opinion in nephrology and hypertension

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Berry Diane (2012) Genetic markers as instruments for mendelian randomisation studies on vitamin D in Proceedings of the 4th International Conference in Quantitative Genetics

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Cavadino Alana (2012) Interactions between VDR and RXR polymorphisms affect metabolic traits in the 1958 British birth cohort in Proceedings of the 4th International Conference in Quantitative Genetics

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Hyppönen E (2013) Vitamin D and pre-eclampsia: original data, systematic review and meta-analysis. in Annals of nutrition & metabolism

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Maddock J (2013) Vitamin D and common mental disorders in mid-life: cross-sectional and prospective findings. in Clinical nutrition (Edinburgh, Scotland)

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Maddock J (2014) 25-Hydroxyvitamin D and cognitive performance in mid-life. in The British journal of nutrition

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Vimaleswaran Karani Santhanakrishnan (2011) Genetic markers as instruments for Mendelian Randomization studies on Vitamin D in Journal of Epidemiology and Community Health

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Vimaleswaran Karani Santhanakrishnan (2012) Obesity is a causal risk factor for low vitamin D status: a bi-directional Mendelian Randomization study on 42,000 individuals. in European Society of Human Genetics (ESHG) website

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Vimaleswaran Karani Santhanakrishnan (2011) Obesity is a causal risk factor for low vitamin D status: a bi-directional Mendelian Randomization study on 40,000 individuals. in Obesity 2011, 29th Annual Scientific meeting website (Poster 846-P).

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Vimaleswaran Karani Santhanakrishnan (2010) Association between BMI and 25(OH)D examined using a genetic approach- the 1958 British Birth Cohort. in Longitudinal and Lifecourse studies

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Vimaleswaran Karani Santhanakrishnan (2012) A causal association between vitamin D status and blood pressure: a Mendelian Randomization study in up to 89,042 individuals. in American Society of Human Genetics (ASHG) 2012 meeting website.

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Vimaleswaran KS (2013) Genetic association analysis of vitamin D pathway with obesity traits. in International journal of obesity (2005)

 
Guideline Title Dietary Reference Intakes for Calcium and Vitamin D
Description Citation in IOM recommendations
Geographic Reach North America 
Policy Influence Type Citation in clinical guidelines
 
Description Scottish Vitamin D summit.
Geographic Reach UK 
Policy Influence Type Participation in a national consultation
Impact Contributed to the evidence base for the need of free vitamin D supplementation. Conclusion by the Scottish governement was, that insufficient evidence to make recommendation at this stage, and avice from SACN will be followed. SACN will be reviewing the evidence again, start 2011.
 
Description Ergocalciferol (Vitamin D2) vs. Cholecalciferol (Vitamin D3) Food Fortification: Comparative Efficiency in Raising 25OHD Status in Caucasian & Asian Women (PI Lanham-New)
Amount £516,000 (GBP)
Funding ID BB/I006192/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 02/2011 
End 03/2014
 
Description Programme in applied and translational cardiovascular genomics:UCLEB (PI Hingorani)
Amount £9,500,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2011 
End 03/2016
 
Description Public Health Importance of Vitamin D (PI Lawlor)
Amount £1,400,000 (GBP)
Funding ID G0701603 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2009 
End 09/2013
 
Description UCL Impact PhD studentship (PI Hypponen)
Amount £63,253 (GBP)
Organisation University College London 
Sector Academic/University
Country United Kingdom
Start 06/2011 
End 06/2014
 
Description Vitamin D -CVD/related traits (PI Hypponen)
Amount £217,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2010 
End 09/2013
 
Description vitamin D and metabolic health; 1966 cohort programme (Hypponen CO-PI with Jarvelin)
Amount £341,714 (GBP)
Organisation Academy of Finland 
Sector Public
Country Finland
Start 01/2011 
End 12/2013
 
Title MR analyses on Vitamin D 
Description Methodological paper describing issues related to using genetic variants as instruments in Mendelian Randomisation studies on vitamin D 
Type Of Material Data analysis technique 
Year Produced 2012 
Provided To Others? Yes  
Impact Methods paper,published in open access journal, highlighted by the Faculty1000 as a paper of special interest. 
 
Title NFBC1966 25(OH)D consentrations 
Description We have measured 25(OH)D consentrations from the participants in the Northern Finland Birth cohort (NFBC)1966 . 
Type Of Material Database/Collection of Data/Biological Samples 
Year Produced 2008 
Provided To Others? Yes  
Impact This extends the data available from NFBC1966, a large resource for population based studies. So far we have used this information as outcome in genomewide association analyses. (Ongoing, also part of SUNLIGHT collaboration). 
 
Title Seasonality methods 
Description Methodological paper describing methods to enable inferences (and quantification) of association for the role of vitamin d to be derived from related seasonal variations. 
Type Of Material Data analysis technique 
Provided To Others? No  
Impact Awaiting formal publication. Methods description will allow the application of methodology to other contexts. 
 
Description D-CarDia 
Organisation Boston University
Department School of Public Health
Country United States 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation Harvard University
Department Harvard Medical School
Country United States 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation Harvard University
Department Harvard T.H. Chan School of Public Health
Country United States 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation Heidelberg University
Country Germany 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation Ludwig Maximilian University of Munich (LMU Munich)
Department Center for Integrated Protein Science Munich (CIPSM)
Country Germany 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation McGill University
Country Canada 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation Sahlgrenska University Hospital
Country Sweden 
Sector Hospitals 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation Tampere University of Technology
Country Finland 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation University of Helsinki
Country Finland 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation University of Maryland
Department School of Medicine Maryland
Country United States 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation University of Oulu
Department Biocenter Oulu
Country Finland 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation University of Tromso
Country Norway 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation University of Turku
Country Finland 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation University of Wageningen
Country Netherlands 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation Uppsala University
Country Sweden 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description D-CarDia 
Organisation Wake Forest University
Department Wake Forest School of Medicine
Country United States 
Sector Academic/University 
PI Contribution EH leads collaboration, ICH main is the analysis site with a post doc appointed for the management of the project with BHF funding (PG/09/023/26860). Research fellow appointed with MRC funding (G0601653), acted as the main analyst for the collaboration (2010-2012).
Collaborator Contribution Collaborators have provided results for the meta-analyses carried out at UCL ICH.
Impact One large meta-analysis submitted, other in advanced draft stages, two further meta-analyses about to be submitted.
Start Year 2010
 
Description EGG/EAGLE 
Organisation University of Oxford
Department Oxford Centre for Diabetes Endocrinology and Metabolism (OCDEM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Statistician working on this MRC funded project, has carried out GWAs meta-analyses and within cohort GWA analyses on birth weight among other tasks, contributing to the work in EGG consortium. Member of EAGLE Steering group, collaborative meta-anlyses on various traits under way.
Collaborator Contribution This collaboration has opened possibilities to collaborate with several large consortia, including EGG, EAGLE, Diagram. Some related outputs have been submitted for publication, others to follow.
Impact These collaborations have already led, and will continue to lead, to further added value for the current MRC funded project, beyond work directly related to vitamin D.
 
Description MRC Centre 
Organisation University College London
Department MRC Centre for Epidemiology for Child Health
Country United Kingdom 
Sector Academic/University 
PI Contribution My research team are an active member in the centre, with a strive to influence policy and practice and contributions to the genetic epidemiolgy group.
Collaborator Contribution • Provision of Epilab: The epiLab is an advanced computing environment and data management service that has been developed at the MRC Centre to support researchers through all aspects of the research data management life-cycle. The service provides core data storage and backup provision in conjunction with a virtualised desktop and backend-server infrastructure, designed to provide high levels of resilience and information security.
Impact Facilitated by the resources provided by the centre, I have expanded my group, published several papers in high profile publications, obtained further research funding, including the new Birth Cohort Resource (in which I am a co-investigator).
Start Year 2007
 
Description NFBC 1966 
Organisation Imperial College London
Department Department of Epidemiology and Biostatistics
Country United Kingdom 
Sector Academic/University 
PI Contribution We have extended the NFBC resource by information on 25(OH)D consentrations. We have also improved the data available by extensive re-coding of data, to allow the retrieval of supplementation data from medications used.
Collaborator Contribution Allows us to use the NFBC resource. The joint recent funding, will contribute towards salary costs for a statistician who will help to take forward collaborative VitD related analyses.
Impact 25OHD consentrations, supplementation data.
 
Description SUNLIGHT 
Organisation Addenbrooke's Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation Agency for Science, Technology and Research (A*STAR)
Department Genome Institute of Singapore
Country Singapore 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation Boston University
Country United States 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation Broad Institute
Country United States 
Sector Charity/Non Profit 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation Cedars-Sinai Medical Center
Country United States 
Sector Hospitals 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation Erasmus University Rotterdam
Country Netherlands 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation Finnish Institute of Occupational Health (FIOH)
Country Finland 
Sector Public 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation Goethe University Frankfurt
Country Germany 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation Harvard University
Department Harvard Medical School
Country United States 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation Indiana University
Country United States 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation Massachusetts General Hospital
Country United States 
Sector Hospitals 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation McGill University
Country Canada 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation National Institute for Health and Welfare (THL)
Country Finland 
Sector Public 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation National Institute on Aging
Country United States 
Sector Public 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation Tufts University
Department Institute for Ageing Research
Country United States 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation University College London
Department Institute of Child Health
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation University of Aberdeen
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation University of Gothenburg
Country Sweden 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation University of Helsinki
Country Finland 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation University of Maryland
Country United States 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation University of Miami
Country United States 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation University of Ottawa
Department Faculty of Medicine
Country Canada 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation University of Oulu
Department Biocenter Oulu
Country Finland 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation University of Oxford
Department Kennedy Institute of Rheumatology
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation University of Pittsburgh
Country United States 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation University of Washington
Country United States 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description SUNLIGHT 
Organisation Wake Forest University
Country United States 
Sector Academic/University 
PI Contribution Co-leading, contributed with MRC funded project ~30% samples for Lancet publication , ICH lead analysis site for second round of meta-analysis. ICH allocated to lead on subsequent sub-analyses.
Collaborator Contribution Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output.Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output. Scientific collaboration leading to high quality output.
Impact 1. *Wang T, *Zhang F, *Richards B, *Kestenbaum B, *van Meurs J, *Berry D, (67 others),*Todd J, *Dupuis J, *Hyppönen E, *Spector T. Common genetic determinants of vitamin D insufficiency: The SUNLIGHT consortium. Lancet. 2010. *contributed equally, EH corresponding author. Two related presentations given at HUGO and CELSE meetings in 2010. Two further SUNLIGHT papers currently under preparation, several in planning.
Start Year 2008
 
Description UCLEB programme 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-ordinated the 1958BC contribution to the analyses. MRC grant funded analyst carrying out the analysis on 1958BC
Collaborator Contribution Scientific collaboration leading to high quality output. The funding provided by the collaboration will contribute towards salary costs for a statistician.
Impact 2 papers published. Recently we obtained specific funding to continue this work (Collaborative programme grant fom BHF).
Start Year 2007
 
Description UCLEB programme 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-ordinated the 1958BC contribution to the analyses. MRC grant funded analyst carrying out the analysis on 1958BC
Collaborator Contribution Scientific collaboration leading to high quality output. The funding provided by the collaboration will contribute towards salary costs for a statistician.
Impact 2 papers published. Recently we obtained specific funding to continue this work (Collaborative programme grant fom BHF).
Start Year 2007
 
Description UCLEB programme 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-ordinated the 1958BC contribution to the analyses. MRC grant funded analyst carrying out the analysis on 1958BC
Collaborator Contribution Scientific collaboration leading to high quality output. The funding provided by the collaboration will contribute towards salary costs for a statistician.
Impact 2 papers published. Recently we obtained specific funding to continue this work (Collaborative programme grant fom BHF).
Start Year 2007
 
Description UCLEB programme 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-ordinated the 1958BC contribution to the analyses. MRC grant funded analyst carrying out the analysis on 1958BC
Collaborator Contribution Scientific collaboration leading to high quality output. The funding provided by the collaboration will contribute towards salary costs for a statistician.
Impact 2 papers published. Recently we obtained specific funding to continue this work (Collaborative programme grant fom BHF).
Start Year 2007
 
Title Gene discovery, 25(OH)D 
Description Novel genetic variants affecting 25(OH)D consentrations and birth weight. 
IP Reference  
Protection Protection not required
Year Protection Granted 2011
Licensed No
Impact These discoveries have led to opportunities to use information on the genes/SNPs implicated, as instruments in "Mendelian randomisation" analyses and/or offered insights into biological pathways related to these traits.
 
Title Gene discovery, childhood obestiy 
Description Novel genetic variants affecting propensity to obesity in childhood. 
IP Reference  
Protection Protection not required
Year Protection Granted 2011
Licensed No
Impact Increased knowledge about the importance of genetic variation in affecting childhood obesity.
 
Title Genetic influences on vitamin D deficiency 
Description We described to ability to predict the risk of vitamin D deficiency using common genetic variations. This work was funded by the MRC, but also by other sources as relevant to the SUNLIGHT collaboration. 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Refinement. Non-clinical
Year Development Stage Completed 2010
Development Status Under active development/distribution
Impact It demonstrated the relatively small but relevant contribution of genetic variation as a determinant of the risk of vitamin D deficiency. Raises some question about the suitability of currently used biomarker for the measurement of vitamin D status, highlighting the need of further research. 
 
Description Annual meeting of British Society of Allergy and Clinical Immunology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Part of scietific vitamin D symposium.

Knowledge dissemination
Year(s) Of Engagement Activity 2011
 
Description BBC4 Case Notes radio programme 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Dr Hypponen gave interview which was included in a programme on "Sun and Skin"

Contacts from audience.
Year(s) Of Engagement Activity 2008
 
Description BBC4 Radio Case notes 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Dr Hypponen appeared on a radio programme on Vitamin D

Distribution of information through radio.
Year(s) Of Engagement Activity 2010
 
Description BBC4 Radio food programme 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Dr Hypponen gave a interview for a programme focused on Vitamin D

Contacts from audience.
Year(s) Of Engagement Activity 2010
 
Description British Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Presentation was given about hypovitaminosis D in Britain and related health consequences in a related seminar targeted at a lay audience.

Interviews to three journalists who we at the audience, led to related articles in a scottish newspaper, main Finnish lay science magazine ("Tiede lehti") and a fairly lengthy article in the "Chemistry World", a magazine published by the Royal Society of Chemistry.
Year(s) Of Engagement Activity 2009
 
Description Interviewed as corresponding co-author in the SUNLIGHT consortium for Lancet press release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Global distribution of news.

The interview was distributed through Reuters
Year(s) Of Engagement Activity 2010
 
Description Invited talk at Conference of the Nordic Midwives Association 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Dr Hypponen gave an invited talk on Vitamin D in pregnancy and the implications for the mother and child

Issues related to presentation were covered by Nordic press/professional journals.
Year(s) Of Engagement Activity 2010
 
Description Measuring and improving vitamin D promotion and prescribing to prenatal and postnatal women within the Northwest. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Health professionals
Results and Impact A meeting to advice on the implementation of vitamin D recommendations within the PCT

Implementation of vitamin D recommendations during pregancy within the PCT.
Year(s) Of Engagement Activity 2011
 
Description Media contact, various 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Various pieces for newspapers (Daily Mail, Telegraph etc.) and magazines (Mens Health, others), mainly responding to queries related to Vitamin D.

Knowledge dissemination
Year(s) Of Engagement Activity 2011
 
Description Press briefing, Science Media Centre 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Primary Audience Media (as a channel to the public)
Results and Impact Dr Hypponen was one of the experts on a background briefing session on vitamin D.

A related article appeared in The Independent. Dr Hypponen was subsequently interviewed by a Brazilian Health journalist and a journalist affiliated with the American Diabetes Association.
Year(s) Of Engagement Activity 2010
 
Description Press release on review paper on Vitamin D in pregnancy 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact The press release was picked up by BBC Radio 4 news and attracted strong interest with distribution through several news agencies.

Contacts from GPs, members of public, members of pharmaceutical companies.
Year(s) Of Engagement Activity 2010
 
Description Public Engagment event, Wellcome trust 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Seminar with an active multidiciplinary audience. Presentation was recored and posted in the you tube.

Further invitations to speak from members in the audience.
Year(s) Of Engagement Activity 2011
 
Description Scottish Summit on Vitamin D 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Policymakers/politicians
Results and Impact Dr Hypponen gave an invited talk on Vitamin D and insights from epidemiological studies at a meeting jointly organised by the Scottish MS Society and the Scottish Government.

Action to improve vitamin D status in Scotland.
Year(s) Of Engagement Activity 2010
 
Description Symposium on "Critical micronutrients in pregnancy, lactation and infancy" . Munich Germany. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Health professionals
Results and Impact Seminar to discuss research needs for evaluating the effect of micronutrient defencies on pregnancy outcomes.

Publication in Annals of Nutrition and Metabolism, in press.
Year(s) Of Engagement Activity 2011
 
Description The 2nd Peckham symposium, ICH UCL 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact A well attended annual "flagship" symposium for our Department.

Knowledge dissemination
Year(s) Of Engagement Activity 2011