University of Edinburgh Centre for Cognitive Ageing & Cognitive Epidemiology supported by BBSRC, EPSRC, ESRC and MRC

Lead Research Organisation: University of Edinburgh
Department Name: Sch of Philosophy Psychology & Language

Abstract

Cognitive ageing and cognitive epidemiology
Professor Ian Deary, Director of the University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology.

We aim to: (1) identify the risk factors for, and mechanisms of, individual differences in age-related cognitive decline; and (2) try to understand why prior cognitive ability-even from childhood-is associated with health and survival in later life.

People differ greatly in the degree to which their brains, and the rest of their bodies, decline with age. Cognitive ageing is complex: there is little age-related decline in some mental functions-such as vocabulary, some numerical skills, and general knowledge-but other mental capabilities decline from middle age onwards, or even earlier. Mental competence is necessary for carrying out everyday activities, living independently, and for general health and wellbeing, and mental capability itself is a causative factor in adult health, especially in old age. Low levels of mental ability, even from early life, and any age-related cognitive decline, are important risk factors for premature illness and death.

We don‘t fully understand the biological foundations of cognitive ageing, and we don‘t fully understand why human intelligence is linked to later health and wellbeing. The Centre is devoted to adding new, practically-useful knowledge to help reduce this ignorance.

Technical Summary

The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology will be a centre of excellence for research and training in cognitive ageing and cognitive epidemiology. Cognitive ageing concerns the impact of age on human cognition and how this contributes to quality of life. Cognitive epidemiology studies how and why cognition influences wellbeing, health and survival.

There are many aspects of ageing that need to be considered: genetic, medical, biological, lifestyle, psychological and social. To understand how each of these influences cognition, the Centre has scientific expertise from each of these specialities. The teams assembled to form the Centre have specific skills in: the psychological study of human cognitive ageing; the medical aspects that influence cognitive ageing in humans and animals; modelling human cognitive ageing in animal and laboratory systems. In addition, the Centre will have collaborators with expertise in: imaging techniques that show how age changes the structure and function of the brain; genetic aspects of brain ageing in humans and animals, and the complex statistical analyses required seamlessly to knit this area together. Forming a Centre will enable these groups to work together so that insights from one area of research can be tested in others. The data used by these scientists also constitute a valuable asset to the Centre with several unique cohorts of human volunteers. For example, the Lothian Birth Cohorts of 1921 and 1936 contain over 1,500 people who had cognitive ability tested both in youth and old age.

Just as there are influences on the body throughout life that affect whether or not the brain ages successfully, the converse is also true. People?s level of cognitive ability, from childhood onwards, influences their later health, wellbeing and survival. The Centre?s scientists will study the reasons for this association and its implications for improving health. They have gathered several, large sets of data from a number of countries to investigate over the next five years.

The Centre?s work will provide new information on: why some people?s mental functioning ages better than others; what the underlying mechanisms are; how cognitive ability affects health and wellbeing and which aspects are affected. The work will be applied to preventing or alleviating the decline in the thinking skills of older people and improving lifelong health and wellbeing.

Organisations

Publications

10 25 50

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Allerhand M (2011) Skin ageing and oxidative stress in a narrow-age cohort of older adults in European Geriatric Medicine

 
Description Age UK policy influencing
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description Brain Imaging in Society - Joanna Wardlaw
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Gave evidence to a government review
 
Description Deary & Logie - Scottish Parliament Committee on Fiscal Sustainability
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Membership of a guidance committee
 
Description Deary - AMRC Summer parliamentary Reception
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description Deary - David Willetts, MP
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description Deary - Resources for Democracy
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description Deary - Scottish Parliament Cross Party Group on Older People Age and Ageing
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in advisory committee
 
Description Dementia and delirium - John Starr/Susie Shenkin
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description EPSRC High Performance Computing Applications Panel - D Lliewald
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Foresight Project on Mental Capital and Wellbeing - Ian Deary, Alan Gow
Geographic Reach Multiple continents/international 
Policy Influence Type Gave evidence to a government review
 
Description Logie - Scottish Parliament round table
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
URL http://news.bbc.co.uk/democracylive/hi/scotland/newsid_9753000/9753290.stm
 
Description MacLullich - 4AT test
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
URL http://www.the4AT.com
 
Description NHS Health Scotland Joint Meeting on Cognitive Ageing
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description NHS Health Scotland Joint Meeting on Cognitive Epidemiology
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Report for the Federation of European Academies of Medicine (FEAM) and All European Academies of Science (ALLEA) - David Hill
Geographic Reach Europe 
Policy Influence Type Participation in a national consultation
URL https://www.allea.org/wp-content/uploads/2018/11/Health_Inequalities_Symposium_Report.pdf.
 
Description Review of cognitive ageing and financial services
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://www.fca.org.uk/publication/research/ageing-mind-literature.pdf
 
Description SAPEA report "Transforming the Future of Ageing" - Alan Gow
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
URL https://ec.europa.eu/research/sam/index.cfm?pg=ageing
 
Description Scottish Government Cross-Party Group on Older People, Age and Ageing
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Shenkin - Dementia strategy groups
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Membership of a guideline committee
 
Description AXA PhD Studentship - Karen Horsburgh
Amount £100,000 (GBP)
Organisation AXA 
Department AXA Research Fund
Sector Private
Country France
Start 09/2011 
End 08/2014
 
Description Age UK Artist in Residence for Fionna Carlisle
Amount £5,000 (GBP)
Organisation Age UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Alzheimer Scotland - New centre grant
Amount £750,000 (GBP)
Organisation Alzheimer Scotland 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2011 
End 12/2015
 
Description Artists grant for Linda Fleming - PI Ian Deary
Amount £3,164 (GBP)
Organisation University of Edinburgh 
Sector Academic/University
Country United Kingdom
Start 04/2010 
End 05/2010
 
Description BA Overseas Conference Grant
Amount £500 (GBP)
Organisation The British Academy 
Sector Academic/University
Country United Kingdom
Start 01/2009 
End 02/2009
 
Description COEN Multicentre Project grant (J Wardlaw P.I.): "Standards for determining the vascular contribution to neurodegeneration"
Amount £20,148 (GBP)
Funding ID MR/J006971/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description CSO Project grant (A hundred at ninety: the common cause hypothesis of ageing tested in four waves of the Lothian Birth Cohort 1921)
Amount £147,766 (GBP)
Funding ID ETM/55 
Organisation Chief Scientist Office 
Sector Public
Country United Kingdom
Start 01/2011 
End 06/2012
 
Description CSO project grant: "Genetic variation in HCN1-4 and its relationship to cognition and depression in individuals from the Generation Scotland: Scottish family Health Study"
Amount £47,804 (GBP)
Funding ID ETM/84 
Organisation Chief Scientist Office 
Sector Public
Country United Kingdom
Start 01/2011 
End 12/2011
 
Description Centre for Clinical Brain Sciences, Travel Grant
Amount £200 (GBP)
Organisation University of Edinburgh 
Sector Academic/University
Country United Kingdom
Start 01/2009 
End 02/2009
 
Description Confidence in Global Mental Health Research 2017
Amount £188,567 (GBP)
Funding ID MR/R01910X/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2018 
End 02/2019
 
Description Deary - Centenary Award
Amount £120,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Deary LLHW grant - 6-Day Sample
Amount £1,399,279 (GBP)
Funding ID G1001401 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Deary and Starr (as Co-Is) - ESRC Administrative Data Research Centre - Scotland
Amount £7,930,752 (GBP)
Funding ID ES/L007487/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 11/2013 
End 10/2018
 
Description Deary programme grant - A hundred at ninety
Amount £147,766 (GBP)
Funding ID ETM/55 
Organisation Chief Scientist Office 
Sector Public
Country United Kingdom
Start 01/2011 
End 12/2012
 
Description Deary programme grant - brain white matter
Amount £808,224 (GBP)
Funding ID G1001245 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Deary/Starr (as Co-Is) - Mood, Mobility and Place
Amount £1,200,000 (GBP)
Funding ID EP/K037404/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Deary/Starr (as Co-Is) - SENIORS USP
Amount £817,140 (GBP)
Organisation Medical Research Council (MRC) 
Department Lifelong Health and Wellbeing (LLHW)
Sector Public
Country United Kingdom
Start  
 
Description Dunhill Medical Research Fellowship (A Barugh) - Alasdair MacLullich
Amount £200,000 (GBP)
Funding ID RTF17/0111 
Organisation The Dunhill Medical Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Guarantors of Brain Travel Grant
Amount £700 (GBP)
Organisation Guarantors of Brain 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Guest Professor - Alan Gow
Amount £19,275 (GBP)
Organisation Nordea Foundation 
Sector Charity/Non Profit
Country Denmark
Start 05/2011 
End 07/2011
 
Description LLHW Project grant: "6-Day Sample of the Scottish Mental Survey 1947"
Amount £1,399,279 (GBP)
Funding ID G1001401 
Organisation Medical Research Council (MRC) 
Department Lifelong Health and Wellbeing (LLHW)
Sector Public
Country United Kingdom
Start 10/2011 
End 03/2016
 
Description MRC Centenary Awards
Amount £24,480 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description MRC Centre Grant
Amount £3,400,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2008 
End 08/2013
 
Description MRC Project grant: "QTL in Health and Disease"
Amount £6,000,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description MRC Project grant: 'Brain white matter imaging and cognitive ageing in the Lothian Birth Cohort of 1936: II'
Amount £808,224 (GBP)
Funding ID G1001245 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 08/2011 
End 03/2015
 
Description MRC Regional Comms Manager funding for Fionna Carlisle
Amount £3,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description MacLullich development grant - DelBox
Amount £18,000 (GBP)
Organisation NHS Education for Scotland (NES) 
Sector Public
Country United Kingdom
Start  
 
Description PhD studentship - Ian Deary/John Starr
Amount £47,000 (GBP)
Organisation Age UK 
Department Research into Ageing Fund (RiAF)
Sector Charity/Non Profit
Country United Kingdom
Start 09/2010 
End 08/2013
 
Description Porteous capital award - Institute of Genetics and Molecular Medicine: Systems Medicine
Amount £3,461,500 (GBP)
Funding ID 092509 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Postdoctoral Fellowship (S Stumm): "The relationship of intelligence and personality and its effect on adult intellect"
Amount £100,147 (GBP)
Funding ID ES/I010173/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 01/2011 
End 12/2012
 
Description Postdoctoral Fellowship - Lorna Lopez/AXA
Amount £46,154 (GBP)
Organisation AXA 
Department AXA Research Fund
Sector Private
Country France
Start 01/2011 
End 12/2011
 
Description Project grant - 3D brain
Amount £1,090 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2010 
End 12/2010
 
Description Project grant - Co PI John Starr
Amount £26,978 (GBP)
Funding ID ART-PPG2010A-1 
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2010 
End 12/2013
 
Description Researcher Mobility Programme MOBILITAS (R Mottus): "Predictors and mechanisms of successful cognitive ageing"
Amount £66,000 (GBP)
Organisation Estonian Science Foundation (ETF) 
Sector Public
Country European Union (EU)
Start 01/2010 
End 12/2012
 
Description Smith programme grant - brain tissue bank
Amount £514,034 (GBP)
Funding ID G1100616 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Starr (as Co-I) - Longitudinal panel study for dementia
Amount £49,300 (GBP)
Organisation The Life Changes Trust 
Sector Private
Country United Kingdom
Start  
 
Description Starr (as Co-I) - PREVENT
Amount £213,000 (GBP)
Organisation Alzheimer’s Society 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Two PhD studentships - James McCulloch/University of Edinburgh
Amount £100,000 (GBP)
Organisation University of Edinburgh 
Sector Academic/University
Country United Kingdom
Start 09/2010 
End 08/2013
 
Description Wardlaw COEN - Standards for determining the vascular contribution to neurodegeneration
Amount £53,899 (GBP)
Funding ID MR/J006971/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Wellcome Trust Centre grant: Wellcome-Wolfson capital award in biomedical science for Institute of Genetics and Molecular Medicine: Systems Medicine"
Amount £3,461,500 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2011 
End 12/2014
 
Title 3D brain 
Description A 3D Brain based on MRI Scans has been developed. This Brain is true 3D in cyberspace and can be viewed and projected in anaglyph 3D and well as a higher quality rendition using a fast shuttered glasses system from Nvidia. Two Brains are available for viewing at the moment , a healthy young and a healthy old brain. The 3D brain can be rotated and zoomed in real time to allow the demonstration of anatomical features on the reconstructed models. The tools developed are capable of importing any 3D model and future developments may include tractography etc. 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2013 
Provided To Others? Yes  
Impact This system was used as a demonstrator at the opening of CRIC by HRH Duke of Edinburgh. In 2011 it was demonstrated at the Edinburgh International Science Festival that attracted ~3000 visitors, at the Glasgow Science Centre, and has been taken around schools by CCACE employee Jack Nissan. In 2014 the 3D brain was demonstrated at the Edinburgh Neuroscience Day (March 12th 2014) and at a reception held by Age UK at St James's Palace and hosted by HRH Prince Charles (Jan 28th 2014). 
 
Title Brain Observer Microbleeds Scale (BOMBS) 
Description If the diagnostic and prognostic significance of brain microbleeds are to be investigated and used for these purposes in clinical practice, observer variation in BMB assessments must be minimised. This scale takes into account the main sources of inter-rater disagreement in rating microbleeds seen in brain imaging, especially in older people. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2009 
Provided To Others? Yes  
Impact This has been published in the journal Stroke and made available to international researchers. This provides a new, well-validated scale for an important aspect of often-ignored brain pathology to be assessed in the older brain. Cordonnier, C., et al (2009) . Improving interrater agreement about brain microbleeds: Development of the brain observer microbleed scale (BOMBS). Stroke, 40, 94-99. 
URL http://www.sbirc.ed.ac.uk/research/imageanalysis.html#bombs
 
Title CCACE - LBC Lifetimes website 
Description The professional writer Ann Lingard composed stories of the lives of members of the Lothian Birth Cohorts of 1921 and 1936 and some of the wscientists working on the research. Each life was "told" as a small online facsimilie book with pictures across the lifecourse of each person. The individual books are professional looking and they have been gathered on to a website. The CCACE Systems Analyst worked closely with the CCACE Knowledge Exchange Officer to develop a new website for a large CCACE arts project called LBC Lifetimes. The project was set up to create stories of the lives and lifetimes of some of the participants and scientists involved in the LBC1936 study. The site has been viewed over 2300 times. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact The stories are available internationally for those wishing to learn more about the personal backgrounds of participants and esearchers in the Lothian Birth Cohort studies. 
URL http://www.lbclifetimes.org
 
Title CCACE hardware implementation - Dave Liewald 
Description The CCACE database manager, Mr Dave Liewald, has developed hardware within the group to support the research activities of CCACE research groups to aid with the collection and analysis of genotypic and phenotypic datasets for CCACE members as well as the daily functions of these groups. To this end a number of individual workstations and laptops, were built and implemented as well as a server cluster to support the large data volumes and concurrent processing needs. In summary, 9 workstations and 6 laptops have been installed which include 6 high performance analysis workstations for the manipulation and analysis of genetic data. A server cluster has been developed which has a number of functions covering the collection, assimilation analysis and distribution of data within the local group and globally with consortia and partners across the world including groups in Australia and the US. The cluster comprises of a number of machines each with specific functions and capabilities. 
Type Of Material Improvements to research infrastructure 
Year Produced 2012 
Provided To Others? Yes  
Impact The new hardware infrastructure has greatly eased the collection and analysis of large scale data for CCACE members to make research more effective. The hardware and software developments are currently being planned for extension, and generalisation for the use of the others via a BBSRC databases grant. 
 
Title CCACE software applications - Dave Liewald 
Description Applications have been developed by the CCACE database manager, Mr Dave Liewald, to help with the repurposing of large GWAS datasets and importing data from a number of data types to the core MySQL database as well as cognitive testing software. Some of these are: Genotype/Phenotype related 1. GWAS : ImputeClean , Takes imputed data output and converts it to standard ped file format 2. GWAS : Genematrix , Takes raw Genomestudio output files and converts them to standard ped files 3. GWAS : Concatenate, during analysis the genotype is split into chromosomes to enable concurrent processing. This concatenates the chromosomes into a single file 4. Import KB Bioscience : imports data to SNP database in the main schema 5. NHS Dataimport : imports CHI data from NHS supplied files 6. Retinal analysis Import : imports retinal analysis data to main datasets 7. SPSS Importer : Imports SPSS data to main datasets Cognitive testing Software 1. Deary-Liewald Reaction time task(DL RT) 2. Puddock ( DL RT for children/young adults) 3. Specific DL RT for Generation Scotland 4. Binding 5. SentenceSpan 6. DigitSpan 7. VisualPattern Other 1. Store and forward data collection system for Scottish Dementia Network 2. Anonymisation system for submitting retinal images to other groups NB Only some of the applications noted here are open source and available to other researchers. Most are kept inhouse. 
Type Of Material Improvements to research infrastructure 
Year Produced 2008 
Provided To Others? Yes  
Impact The hardware and software developments are currently being planned for extension, and generalisation for the use of the others via a BBSRC databases grant. 
 
Title CCACE websites and web applications - Dave Liewald 
Description The CCACE database manager, Mr Dave Liewald, has developed a number of websites for both internal and associated groups which are being hosted on the CCACE server cluster. These sites serve to collect and disseminate information to the groups and general public. These sites are: 1. CCACE Website 2. Disconnected Mind Website 3. Lothian Birth Cohort Website 4. Lothian Birth Cohort Infoserve : Intraweb for Statistical Genetic Group 5. EMCAGS : Edinburgh Manchester GWAS support Site 6. Sir Godfrey Hilton Thomson Collection Website 7. Scottish Dementia Network Website A download service has also been created on the web server for distribution of large data files between groups. Web applications are either CGI or ISAPI web server extensions that are created for secure collection and dissemination of data across the web. These applications are created in Delphi using a specialist collection of objects known as intra web which create secure robust web applications which rely heavily on javascript and Ajax to function. Applications created by the CCACE database manager include: 1. Phenotype Data Browser 2. Candidate gene system 3. LBC-Visage : Photograph Browser 4. Participant register 5. Prototype Volunteer Management System 6. Brain Imaging Data Upload 7. Brain Imaging Diagnostic Recording 
Type Of Material Improvements to research infrastructure 
Year Produced 2008 
Provided To Others? Yes  
Impact The websites are the vehicle by which the Centre is making available its cognitive tests to other researchers. 
 
Title Data collection systems - Dave Liewald 
Description The CCACE database manager has developed two data collection systems. 1) Two web based data collection systems were developed for SBRIC. These collect measurements from scans either by direct entry of the uploading of excel spreadsheets. 2) Two web based IPIP50 collection systems were created an successfully used to collect data from the general public and Students prior to lectures. 
Type Of Material Improvements to research infrastructure 
Year Produced 2009 
Provided To Others? Yes  
Impact Data using these systems is currently being collected and analysed for publication in scientific papers. 
 
Title Image analysis method - hippocampal shape modelling 
Description In collaboration with the Korean Advanced Institute for Science and Technology, we have developed a novel method for hippocampal shape modelling. 
Type Of Material Physiological assessment or outcome measure 
Provided To Others? No  
Impact Cox SR*, Valdés Hernández MC*, Kim J, Royle NA, MacPherson SE, Ferguson KJ, Muñoz Maniega S, Anglaban D, Aribisala BS, Bastin ME, Park J, Starr JM, Deary IJ, MacLullich AJM, Wardlaw JM. Associations between hippocampal morphology, diffusion characteristics, and salivary cortisol in older men. Psychoneuroendocrinology, doi: 10.1016/j.psyneuen.2017.01.027. Kim J, Valdés Hernández MC, Royle NA, Park J. Hippocampal shape modelling based on a progressive template surface deformation and its verification. IEEE Trans Med Imaging 2015 Jun;34(6):1242-61 Valdés Hernández MC, Cox SR, Kim J, Royle NA, Muñoz Maniega S, Gow AJ, Anglaban D, Bastin ME, Park J, Starr JM, Wardlaw JM, Deary IJ. Hippocampal morphology and cognitive functions in community-dwelling older people: the Lothian Birth Cohort 1936. Neurobiol Aging in press. 
URL http://ieeexplore.ieee.org/document/6990617/?reload=true
 
Title Image analysis method - new automated segmentation tool for multifocal basal ganglia hypointeisities 
Description A new tool for automated segmentation of multifocal basal ganglia T2*-weighted hypointensities 
Type Of Material Physiological assessment or outcome measure 
Provided To Others? No  
Impact Glatz A, Bastin ME, Kiker AJ, Deary IJ, Wardlaw JM, Valdés Hernández MC. Automated segmentation of multifocal basal ganglia T2*-weighted MRI hypointensities. Neuroimage 2015 Jan 105: 332-346. 
 
Title Imputation work-flow system - Dave Liewald 
Description The CCACE database manager has created an imputation work-flow system that manages a multiprocessor system and data-flow to enable the imputation of GWAS data against both Hapmap2 and Hapmap3. 
Type Of Material Improvements to research infrastructure 
Year Produced 2010 
Provided To Others? Yes  
Impact This system has successfully imputed a number of datasets that are now in use in a number of international consortia investigating cognitive ageing and decline. In 2011, these tools have allowed imputed datasets to be created from the raw GWAS analysis of 5 Cohorts. All of the GWAS results for the cohorts we hold are now available as raw, HAPII and HAPIII imputed datasets. This has allowed the LBC datasets to be submitted to approximately 30 major international multi-cohort studies covering a very wide range of analyses. 
 
Title Liewald - CCACE cluster 
Description The CCACE computer cluster has been designed to allow it to deal with large GWAS datasets held by CCACE such as 1000G, exome sequencing and also the Generation Scotland reference genome sets. In conjunction with this are new file handling and merging techniques and pipelines which had to be developed to allow researchers to access and utilise these huge data resources. 
Type Of Material Biological samples 
Provided To Others? No  
Impact We have the capability of conducting, securely, large scale genetic analyses for our team and of allowing access to collaborators internationally. 
 
Title Multitasking study tool - Robert Logie, Jack Nissan 
Description CCACE group leader, Professor Robert Logie, and CCACE human testing technician, Mr Jack Nissan, are involved in the development of a new research tools for studying multitasking. Centre members are using this tool to collect data, and the first phase of data collection finished very recently. Professor Logie and Mr Nissan would want to publish results before making the tool available to others, but intend to do make this tool widely available. 
Type Of Material Physiological assessment or outcome measure 
Provided To Others? No  
Impact Professor Logie gave a talk on the tool to the Psychonomics Society in Boston on 22nd November 2009. 
 
Title New method of perivascular space segmentation on brain MRI 
Description MRC-funded imaging team on the LBC1936 developed a new method of perivascular space segmentation, which shows good concordance with neuroradiological assessments. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2016 
Provided To Others? Yes  
Impact Ballerini L, Lovreglio R, Valdés Hernández MC, Gonzalez-Castro V, Muñoz Maniega S, Pellegrini E, Bastin ME, Deary IJ, Wardlaw JM. Application of the ordered logit model to optimising Frangi filter parameters for segmentation of perivascular spaces. Procedia Comp Sci 2016 90:61-67. 
URL http://www.sciencedirect.com/science/article/pii/S1877050916311899
 
Title Reference white matter tracts 
Description We created a set of images depicting the geometry of some of the main of white matter tracts to be used as reference in the segmentation of white matter tracts from diffusion MRI data with tractography methods. These tracts were made available online in two batches, on the 13/02/09 and the 21/08/09 as part of a tractography software package called TractoR (http://code.google.com/p/tractor/). More info about the tracts is in http://code.google.com/p/tractor/wiki/ReferenceTracts. 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2009 
Provided To Others? Yes  
Impact Reference tracts for DTI tractography in elderly participants. 
URL http://code.google.com/p/tractor/
 
Title Shenkin - Training course in systematic reviews 
Description Developed course in systematic reviews and meta-analysis (attended by ~20 students and staff members 2011, 2012 and 2013, with similar number signed up for full day course Dec 2014), and online resource freely available with step-by-step guidance on performing systematic reviews and meta-analyses, and useful resources. http://tinyurl.com/sysrev (online Sep, 2011). Lectures also being used as part of the CARMMS course in CCACE, and MSc in neuroimaging for research. 
Type Of Material Improvements to research infrastructure 
Year Produced 2011 
Provided To Others? Yes  
Impact The course materials are being widely used across the UK. 
URL http://tinyurl.com/sysrev
 
Title Wardlaw - Imaging-related research tools 
Description Wardlaw's group continues to develop a large number of imaging-related research tools for visual assessment of images and computational quantitative measurements. These include methods for measuring white matter hyperintensities, brain mineral deposition, perivascular space enlargement, and brain shrinkage. Links to these tools are available through the Brain Research Imaging Centre website (www.sbirc.ed.ac.uk/research/imageanalysis.html). 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2010 
Provided To Others? Yes  
Impact Members of the neuroimaging group have been invited to speak about their materials in London, Austria, North America, and at majpr conferences such as the European Society of Magnetic Resonance in Medicine. 
URL http://www.sbirc.ed.ac.uk/research/imageanalysis.html
 
Title Brain Images of Normal Subjects (BRAINS) Imagebank 
Description The Brain Images of Normal Subjects (BRAINS) imagebank is an integrated repository project sponsored by the University of Edinburgh and the Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE) collaborators. The purpose of BRAINS is to provide sharing and archiving of detailed normal human brain imaging and relevant phenotypic data, to create better estimates of the range of normal brain size and integrity across the life-course. The Lothian Birth Cohort 1921 and 1936 brain imaging data along with limited clinical data has been added to this resource. BRAINS is a living imagebank where new data will be added when available. Initially BRAINS will contain existing data from n=763 healthy volunteer subjects, range neonatal and 19-81 years of age, from projects in 3 centres. A further n=2119 subjects aged from prenatal to 90 years old with existing records from 15 other projects in Scotland are currently being collected, collated and quality control (QC) checked. Additional completed and ongoing studies of normal individuals will be uploaded as they become available. The data include several magnetic resonance imaging (MRI) sequences, including T1, T2, T2*, fluid attenuated inversion recovery (FLAIR), and Diffusion Tensor Imaging (DTI), in DICOM and NIfTI format, and a wide range of linked metadata, such as age, history, physiological measures (e.g. blood pressure), cognitive ability, and perinatal information (neonatal data). Data access is governed by a steering committee comprising the PIs of the contributing studies, experts in ethics, law and governance, and lay representatives. Applications for data access can be made online, and will be granted by the steering committee subject to the completion of a formal Data Access Agreement. http://www.brainsimagebank.ac.uk/ 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact The initial publication which describes the resource was: "A brain imaging repository of normal structural MRI across the life course: Brain Images of Normal Subjects (BRAINS)" Dominic E Job, David A Dickie, David Rodriguez, Andrew Robson, Cyril Pernet, Mark Bastin, James P Boardman, Alison D Murray, Trevor Ahearn, Gordon D Waiter, Roger T Staff, Ian J Deary, Susan D Shenkin, Joanna M Wardlaw. NeuroImage. doi: 10.1016/j.neuroimage.2016.01.027 PMID: 26794641. We have developed seven age-specific atlases of T1 brain MRI from 25 to 92 years, which have been made available on the BRAINS website. Dickie, David Alexander; Job, Dominic E.; Rodriguez, David; Robson, Andrew; Danso, Samuel; Pernet, Cyril; Bastin, Mark E.; Deary, Ian J.; Shenkin, Susan D.; Wardlaw, Joanna M.. (2016). Brain Imaging of Normal Subjects (BRAINS) age-specific MRI atlases from young adults to the very elderly (v1.0), [dataset]. University of Edinburgh, Edinburgh Imaging, CCBS, BRAINS Imagebank. http://dx.doi.org/10.7488/ds/1369. 
URL http://www.brainsimagebank.ac.uk
 
Description "Computational approach towards the characterisation of global and subregional brain changes with ageing and on the presence of cerebrovascular and neurodegenerative diseases" 
Organisation Korea Advanced Institute of Science and Technology (KAIST)
Department Computer Science Department
Country Korea, Republic of 
Sector Academic/University 
PI Contribution BRIC and Computer Graphics and Visualisation Research Lab, Computer Science Department We provided the reference segmentations (i.e. binary masks) of all the brain structures to be analysed within the context of this project, and on a visit done to KAIST on March we tested the hippocampal model previously developed by KAIST on a wider representative sample and together with KAIST collaborators we improved it incorporating alternative deformation procedures, and developed and tested a pipeline to determine the anatomical deformation to analyse shape variation on subgroups of the sample provided through the calculation of regional variations. The results showed that there are specific areas in the hippocampi for which the deformation is the opposite within each subgroup pair, strongly suggesting that these areas are related to the cognitive/biological parameter evaluated (i.e. general cognition, information processing speed, hypertension, etc). The analysis of the deformation in relation to gender revealed negligible differences between males and females, suggesting that the patterns seen in the analysis of the rest of the biological and cognitive parameters were independent and not determined/influenced by gender differences. We are currently drafting two manuscripts with these results. During the visit, we also agreed on a follow-up plan that includes the generation of the mesh models for other brain structures and evaluated alternatives to pursue them.
Collaborator Contribution Korea Advanced Institute of Science and Technology (KAIST
Impact Up to date, we have obtained 2 grants: one small grant for visiting KAIST (£2,240) and the grant that funds this collaboration for 2 years (£35,143.93) and are writing 2 publications.
Start Year 2011
 
Description ActiveAge 
Organisation BusinessLab
Country United Kingdom 
Sector Private 
PI Contribution The CCACE scientific administrator, Dr Beverly Roberts, attend the 2009 ActiveAge summit in Newcastle to alert members to the existence of the Centre. On the strength of this the CCACE is now a member of this group which discusses ways to tackle issues such as wellbeing, community, work and mobility in elderly individuals.
Impact The CCACE is now a known research group within the ActiveAge group and the Centre is working towards establishing more formal collaborations with the network.
Start Year 2009
 
Description Allerhand - body mass index and cognitive ageing 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution The CCACE statistician contributed expertise to a project examining associations between body mass index and cognitive ageing.
Collaborator Contribution A researcher (Dr Anna Dahl) from Karolinska spent several months overall at CCACE to work on data and use the expertise available at CCACE.
Impact Manuscripts are under preparation.
Start Year 2012
 
Description Alzheimer Scotland 
Organisation Alzheimer Scotland
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Clinical Research Training Fellowship collaboration with the Scottish Dementia Clinical Research Network (David Batty is Co-Supervisor), analyses based on the Lothian Birth Cohorts
Collaborator Contribution Clinical Research Training Fellowship
Impact The Fellow has been appointed (Dr Tom Russ) and his research is progressing well
Start Year 2009
 
Description BSPID - Beverly Roberts 
Organisation British Society for the Psychology of Individual Differences (BSPID)
Country United Kingdom 
Sector Learned Society 
PI Contribution The CCACE scientific administrator is the conference organiser for the society. CCACE hosted the inaugural conference for the society in 2010 and organised conferences in 2011, 2012, 2013 and 2014.
Collaborator Contribution See above.
Impact Conference hosted and keynote talk given. Gaining a wider recognition of the work of CCACE among individual differences researchers in the UK.
Start Year 2009
 
Description British Library - Beverly Roberts/Robin Morton 
Organisation The British Library
Country United Kingdom 
Sector Public 
PI Contribution The British Library contacted the CCACE scientific administrator to determine whether the Centre would be interested in submitting a joint grant proposal on ageing. Initial meetings have been held to determine where there are overlaps of interest.
Collaborator Contribution See above
Impact Talks are currently underway for the submission of a grant proposal.
Start Year 2010
 
Description British Society for the Psychology of Individual Differences (BSPID) 
Organisation British Society for the Psychology of Individual Differences (BSPID)
Country United Kingdom 
Sector Learned Society 
PI Contribution The British Society for the Psychology of Individual Differences (BSPID) is a new academic society formed in November 2009. As members of the CCACE are one of the major contributors to the individual differences research area in the UK the CCACE was invited to be a member of the founding committee and Beverly Roberts (Scientific Administrator) has taken the role of Society Conference Organiser. The CCACE will organise, run and host the first scientific meeting of the BSPID which will be held in Edinburgh in Spring 2010. A number of Centre members are all founding members of the BSPID.
Impact Beverly Roberts organised the first scientific conference in spring 2010. CCACE Director, Ian Deary, has been invited to give the keynote address at this meeting. Beverly Roberts and the CCACE commissioned a professional graphic designer to design the BSPID logo.
Start Year 2009
 
Description CCACE - Oregon Health and Sciences University (OHSU) 
Organisation Oregon Health and Science University
Department Layton Aging & Alzheimer's Disease Center
Country United States 
Sector Academic/University 
PI Contribution CCACE hosted a visit from the Oregon Health and Sciences University team of senior scientists (8 people) in September 2013. The aim was to develop more formal collaborations between the UK and USA in ageing research. The team spent 2 days with CCACE in various meet the staff meetings.
Collaborator Contribution The OHSU team have offered to host 3 members of CCACE on a return visit to Oregon in February 2014. Further correspondence has taken place between Dr Alex WEiss and Professor Jean Manson and the team at Oregon and planned collaborations are ongoing.
Impact There are plans to create formal collaborations between CCACE and OHSU scienitsts that will result after the reciprocal visit. This is intended to lead to joint publications between CCACE and OHSU.
Start Year 2013
 
Description CRFR - Beverly Roberts/Robin Morton 
Organisation University of Edinburgh
Department Centre for Research in Families and Relationships (CRFR)
Country United Kingdom 
Sector Academic/University 
PI Contribution After initial discussions between the Directors of both CCACE and CRFR, the CCACE scientific administrator and KE officer set up joint meetings to discuss possible overlaps of research interest.
Collaborator Contribution The group have provided expertise to widen the Centre's area of research.
Impact Both groups are in discussions and plan to put together a joint grant proposal for submission in 2011. An outlinr application was successful.
Start Year 2010
 
Description Carroll, Moss - University of Birmingham 
Organisation University of Birmingham
Department College of Life and Environmental Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Personality and cognition expertise, analysis and co-authorship
Collaborator Contribution Epidemiological expertise, analysis and co-authorship
Impact Publications: 19321850 19344891 20624519 20875850 20045139 20624519 20875850 20875850 21166685 21709165 21871931 23938060 23434472
Start Year 2008
 
Description Celtic Ageing Network - Bevely Roberts 
Organisation Swansea University
Country United Kingdom 
Sector Academic/University 
PI Contribution The Celtic Ageing Network was set up by staff at the University of Swansea to bring together academics, policy makers, practitioners and researchers in ageing from the UK devolved nations. The CCACE scientific administrator made initial contact with the group at the CogWorks conference in Belfast.
Impact The Centre is now a formal member of the network and a grant application is currently being planned to examine social attitudes to ageing with CCACE as a co-applicant.
Start Year 2010
 
Description Centres of Excellence in Neurogeneration 
Organisation Canadian Institutes of Health Research
Country Canada 
Sector Public 
PI Contribution The organisation of two international workshops in 2012 to prepare and test agreed exemplars and advisory materials. Expertise in standards for determining the vascular contirbution to neurogeneration.
Collaborator Contribution Expertise on establishing standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogeneration
Impact The Centre has organised the first workshop in 2012, at which all collaborators and partners will attend.
Start Year 2011
 
Description Centres of Excellence in Neurogeneration 
Organisation German Centre for Neurodegenerative Diseases
Country Germany 
Sector Public 
PI Contribution The organisation of two international workshops in 2012 to prepare and test agreed exemplars and advisory materials. Expertise in standards for determining the vascular contirbution to neurogeneration.
Collaborator Contribution Expertise on establishing standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogeneration
Impact The Centre has organised the first workshop in 2012, at which all collaborators and partners will attend.
Start Year 2011
 
Description Centres of Excellence in Neurogeneration 
Organisation German Centre for Neurodegenerative Diseases
Country Germany 
Sector Public 
PI Contribution The organisation of two international workshops in 2012 to prepare and test agreed exemplars and advisory materials. Expertise in standards for determining the vascular contirbution to neurogeneration.
Collaborator Contribution Expertise on establishing standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogeneration
Impact The Centre has organised the first workshop in 2012, at which all collaborators and partners will attend.
Start Year 2011
 
Description Centres of Excellence in Neurogeneration 
Organisation Newcastle University
Department MRC Centre for Brain Ageing and Vitality
Country United Kingdom 
Sector Public 
PI Contribution The organisation of two international workshops in 2012 to prepare and test agreed exemplars and advisory materials. Expertise in standards for determining the vascular contirbution to neurogeneration.
Collaborator Contribution Expertise on establishing standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogeneration
Impact The Centre has organised the first workshop in 2012, at which all collaborators and partners will attend.
Start Year 2011
 
Description Centres of Excellence in Neurogeneration 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution The organisation of two international workshops in 2012 to prepare and test agreed exemplars and advisory materials. Expertise in standards for determining the vascular contirbution to neurogeneration.
Collaborator Contribution Expertise on establishing standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogeneration
Impact The Centre has organised the first workshop in 2012, at which all collaborators and partners will attend.
Start Year 2011
 
Description Centres of Excellence in Neurogeneration 
Organisation University of British Columbia
Country Canada 
Sector Academic/University 
PI Contribution The organisation of two international workshops in 2012 to prepare and test agreed exemplars and advisory materials. Expertise in standards for determining the vascular contirbution to neurogeneration.
Collaborator Contribution Expertise on establishing standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogeneration
Impact The Centre has organised the first workshop in 2012, at which all collaborators and partners will attend.
Start Year 2011
 
Description Centres of Excellence in Neurogeneration 
Organisation University of Rostock
Country Germany 
Sector Academic/University 
PI Contribution The organisation of two international workshops in 2012 to prepare and test agreed exemplars and advisory materials. Expertise in standards for determining the vascular contirbution to neurogeneration.
Collaborator Contribution Expertise on establishing standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogeneration
Impact The Centre has organised the first workshop in 2012, at which all collaborators and partners will attend.
Start Year 2011
 
Description Centres of Excellence in Neurogeneration 
Organisation University of Toronto
Country Canada 
Sector Academic/University 
PI Contribution The organisation of two international workshops in 2012 to prepare and test agreed exemplars and advisory materials. Expertise in standards for determining the vascular contirbution to neurogeneration.
Collaborator Contribution Expertise on establishing standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogenerationExpertise in standards for determining the vascular contirbution to neurogeneration
Impact The Centre has organised the first workshop in 2012, at which all collaborators and partners will attend.
Start Year 2011
 
Description CogWorks - Beverly Roberts 
Organisation Queen's University Belfast
Country United Kingdom 
Sector Academic/University 
PI Contribution CogWorks is a research network based in Belfast which was also funded under the LLHW scheme. The CCACE scientific administrator attended their annual sientific meeting in 2010 to develop formal collaborations between the groups.
Collaborator Contribution The CCACE scientific administrator attended their annual sientific meeting in 2010 to develop formal collaborations between the groups.
Impact Reciprocal scientific vists between the two Centres have taken place.
Start Year 2010
 
Description Cognitive Ageing Genetics in England and Scotland (CAGES) consortium 
Organisation Cognitive Ageing Genetics in England and Scotland consortium
Country United Kingdom 
Sector Academic/University 
PI Contribution The CAGES consortium aims to perform GWAS meta-analysis of cognition in old age using data from the LBC1921 and LBC1936 studeies with other international collaborators.
Collaborator Contribution The group has provided data for meta-analysis.
Impact Data from the LBC1921 and LBC1936 studies have been transferred for meta-analysis. Papers on cognition and old age have begun to appear: 21826061. In addition, a paper has been accepted for Nature. Further analyses are being conducted and papers are being prepared.
Start Year 2010
 
Description Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) cognitive consortium 
Organisation International Heart and Aging Research Genetics Consortium
Country United States 
Sector Public 
PI Contribution The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium was formed to facilitate genome-wide association study meta-anlayses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. Cognitive measurements from the Lothian Birth Cohorts have been added to the NeuroCHARGE group and meta-analysis is in progress.
Collaborator Contribution It has provided data for the team to perform meta-anlaysis.
Impact A material transfer agreement is in place with the CHARGE consortium. We have already provided data from the LBC1921 and LBC1936 cohorts. Anlayses have already been initiated. Various brain and blood-related traits are now being investigated including brain imaging, prothrombin time, activated partial thromboplastin time, d-dimer, serum uric acid, serum albumin, fibrinogen. A 2-weekly conference call takes place. A first series of publications is being planned on the basis of the traits noted above. The following publications have appeared: 21909110 21946350 21502573. Other analyses are completed and publications planned. Deary and Davies in CCACE are leading the CHARGE analysis of general cognitive ability and analyses are in progress and a publication is being prepared.
Start Year 2009
 
Description Cox - Interconnectivity of Cerebral Sites - Colab. Pilot 
Organisation Lagos State University
Department Department of Computer Science
Country Nigeria 
Sector Academic/University 
PI Contribution Provided the concept and neuranatomical basis for development of a study specific method for identifying and measuring white matter connectivity between cerebral regions in older participants.
Collaborator Contribution The proposed study represents an international collaborative effort that marries expertise in neuropsychology, neuroanatomy, computer science and ageing research.
Impact A method for exploiting manual frontal lobe parcellations to measure specific site-to-site white matter connectivity in the brains of older persons. In addition to the method development, several manuscripts are planned which will examine the cognitive correlates of individual differences in intra-frontal and fronto-hippocampal connections. Preliminary results presented at two conferences (OHBM 2014 by Aribisala, and ISMRMB 2014 by Cox). Manuscript in preparation, collaboration with Psychiatry at UoE (Prof Lawrie) using this method in preliminary stages. Additional development work planned for use in the Lothian Birth cohorts.
Start Year 2013
 
Description Danish Twin Study 
Organisation University of Copenhagen
Department Center for Healthy Aging
Country Denmark 
Sector Academic/University 
PI Contribution Statistical analyis and writing of papers.
Collaborator Contribution Extensive data on twin samples.
Impact Publications: 19208755 19861402 Johnson et al. (2009) Behaviour Genetics 39;659
Start Year 2008
 
Description David Bartholomew 
Organisation London School of Economics and Political Science (University of London)
Department Department of Social Policy
Country United Kingdom 
Sector Academic/University 
PI Contribution Professor David Bartholomew is a retired professor from the London School of Economics. Ian Deary collaborates with Professor Bartholomew on the biologiy and modelling of cognitive functions. The CCACE statistician, Dr Mike Allerhand, has been added to this collaboration. Dr Allerhand is completing the statistical analysis for a collaborative project on random number generators and a simulation of Thomson's "bonds" (group factor) model.
Collaborator Contribution See above.
Impact Two published papers have appeared from this collaboration, and one more is submitted. One of the publications is a major theoretical contribution to the biological and statistical conception of ability differences and ageing 19618987 19321036. This collaborations' outputs have also been presented at conferences, including the History of Education group conference in Scotland and the British Psychological Society's history and philosophy group's annual conference. A further publication appeared in 2013: http://dx.doi.org/10.1016/j.intell.2013.03.007
Start Year 2009
 
Description Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) consortium 
Organisation National Center for Biotechnology Information (NCBI)
Country United States 
Sector Public 
PI Contribution The ENIGMA consortium aims to perform meta-analysis of brain imaging and genetics in ageing using data from the LBC1921 and LBC1936 studies with other international collaborators.
Collaborator Contribution Data from international collaborators has been brought together to perfom meta-analysis.
Impact Data from the LBC1921 and LBC1936 has been transferred for meta-analysis. Papers on brain imaging, genetics and ageing are currently being prepared. One paper is in revision with Nature Genetics titled "Common genetic polymorphisms contribute to the variation in human hippocampal and intracranial volume". Potentially this collaboration with ENIGMA will extend to include analysis of subcortical brain structures. Also, Deary has made a proposal to take a lead on the GWAS analysis of brain white matter integrity.
Start Year 2010
 
Description Euan Macdonald Centre for Motor Neurone Disease Research 
Organisation University of Edinburgh
Department Euan Macdonald Centre for Motor Neurone Disease Research
Country United Kingdom 
Sector Public 
PI Contribution Centre member Dr Sharon Abrahams, together with Professor Ian Deary begin_of_the_skype_highlighting     end_of_the_skype_highlighting and Professor Siddharthan Chandran, set up the first joint Euan Macdonald Centre for Motor Neurone Disease Research and CCACE Capacity Building PhD Studentship. This PhD initiative is with the recently opened Motor Neurone Disease Centre in Edinburgh of which Dr Abrahams is a founding member.
Collaborator Contribution Formation of a joint Centre capacity building PhD studentship.
Impact A PhD studentship on executive dysfunction, speed of information processing and white matter changes in Motor Neurone Disease. The studentship began in 2009 and the PhD will be completed by 2012. Analyses are in progress and publications are in preparation.
Start Year 2009
 
Description GERAD consortium 
Organisation Medical Research Council (MRC)
Department MRC Centre for Neuropsychiatric Genetics and Genomics
Country United Kingdom 
Sector Public 
PI Contribution GERAD is a large case-control study of Alzheimer's disease run from the MRC Centre for Psychiatric Genetics at Cardiff Univeristy in Wales. The Lothian Birth Cohorts 1921 and 1936, studies led by Professor Ian Deary, will be used as controls in this study.
Collaborator Contribution Collaborators have brought data and expertise.
Impact A material transfer agreement has been completed between the two institutions. Data from the GWAS studies of Ian Deary's cohorts in Edinburgh have been prepared and are being transferred to Cardiff for collaborative analyses. The following publication appeared in the Journal of Alzheimer's Disease in 2011: 22027014. Further analyses are being conducted and papers being prepared. 22693153
Start Year 2009
 
Description GERAD consortium - GWAS of Alzheimer's disease 
Organisation Genetic and Environmental Risk in Alzheimer's Disease (GERAD)
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution GERAD provided us with summary data from a large genome-wide association study of Alzheimer's Disease. From this we created polygenic risk scores for Alzheimer's disease in members of LBC1936, LBC1921, ABC1936 and the Manchester and Newcastle Longitudinal Studies of Cognitive Ageing.
Collaborator Contribution See above.
Impact The following publication has arisen: Harris SE, Davies G, Luciano M, Payton A, Fox HC, Haggarty P, Ollier W, Horan M, Porteous DJ, the Genetic and Environmental Risk for Alzheimer's Disease (GERAD1) Consortium, Starr JM, Whalley LJ, Pendleton N, Deary IJ (2014) Polygenic risk for Alzheimer's Disease is not associated with cognitive ability or cognitive aging in non-demented older people. Journal of Alzheimer's Disease. 39(3):565-74. doi: 10.3233/JAD-131058.
Start Year 2012
 
Description Genetic nodes and network for human episodic memory 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Genome-wide association analyses of memory phenotypes were performed on the Lothian Birth Cohorts in an attempt to replicate findings from a co-expression network analysis performed on human hippocampus samples.
Collaborator Contribution They contributed data and expertise.
Impact We were able to successfully replicate these findings and a manuscript is in preparation.
Start Year 2013
 
Description Genome Wide Association Study (GWAS) of personality 
Organisation National Institute on Aging
Country United States 
Sector Public 
PI Contribution Nine research groups (of which Edinburgh is one) are contributing to a GWAS consortium study of personality. It is headed by Paul Costa Jr.
Collaborator Contribution Collaborators have brought data and expertise.
Impact Our data have already been sent to the consortium and a paper with total N = 16000 subjects has been published in Molecular Psychiatry: 21173776. Further analysis and publications are being prepared.
Start Year 2008
 
Description Glasgow Science Centre 
Organisation Glasgow Science Centre
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution The Centre's knowledge exchange officer, Dr Robin Morton, has made contact with Robin Hoyle who is Science Director at the Glasgow based Science Centre.
Impact Robin Morton has attended one meeting with the Glasgow Science Centre with the result that they are now keen to involve the Centre in future displays. The Science Centre are interested in taking some matrial from the CCACE to show examples of "live" research in their new "labs" for the public. The work of some CCACE members will be used for this.
Start Year 2009
 
Description Glasgow University global methylation 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution Analysed data.
Collaborator Contribution They measured global methylation levels in Lothian Birth Cohort 1936 samples.
Impact Global methylation content and cognitive and physical ability in old age: the Lothian Birth Cohort 1936. Sarah Harris (CCACE Bioinformatician) analysed the data and presented it at the The Epigenomics of Complex Diseases meeting at Johns Hopkins University 12th -15th October 2012.
Start Year 2011
 
Description HALCyon 
Organisation HALCyon
Country United Kingdom 
Sector Academic/University 
PI Contribution The HALCyon collaborative research programme is funded by the UK Research Councils. From the Centre, Ian Deary, John Starr and Catherine Gale are PI's. The Centre receives funding from HALCyon. It is a consortium of ageing cohorts across the UK which has the aim of helping improve the lives of older people through better understanding of how healthy ageing is affected by social, psychological and biological factors acting across the whole of a person?EUR(TM)s life. It brings together an interdisciplinary group of scientists working on nine UK cohort studies to understand three main aspects of healthy ageing. The Edinburgh based Lothian Birth Cohort 1936 study forms one of the nine cohorts who contribute data.
Collaborator Contribution Data from the LBC 1936 and 1921 studies have contributed to the overall meta-analysis.
Impact Publications are emerging. The following papers have been published: 19864640 20214846 20843964 21225350 21297868 21332924 21349224 21542061 22114723 25073452 24563560 24365661 23922731 23894584. Further analyses are underway and publications are being prepared.
Start Year 2008
 
Description INNOGEN Centre 
Organisation Economic and Social Research Council
Country United Kingdom 
Sector Public 
PI Contribution The CCACE has a large genetics team and through the Centre's knowledge exchange officer, Dr Robin Morton, the CCACE and INNOGEN have now formed formal links to work together on genetics and genomics. Robin Morton is in conversation with Ms Lara Crossland who is INNOGEN's communication and networking officer.
Impact Robin Morton has atteded one meeting with the group which has raised the profile of the CCACE.
Start Year 2009
 
Description International Consortia of Blood Pressure (ICBP-GWAS) 
Organisation International Consortia of Blood Pressure (ICBP-GWAS)
Country United States 
Sector Public 
PI Contribution The ICBP-GWAS consortium aims to perform GWAS meta-analysis of blood pressure data using data from the LBC1921 and LBC1936 studies with other international collaborators.
Collaborator Contribution Data sharing between Edinburgh and international collaborators in ongoing.
Impact Data from the LBC1921 and LBC1936 studies have been transferred for meta-analysis work. The following paper has appeared: 21909110
Start Year 2010
 
Description International genetics collaboration investigating runs of homozygosity (ROHgen) 
Organisation University of Edinburgh
Department Centre for Population Health Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution This is an international collaboration investigating the effects of runs of homozygosity on a number of health-related traits including cognition. Manuscript in preparation.
Collaborator Contribution This is an international collaboration investigating the effects of runs of homozygosity on a number of health-related traits including cognition. Manuscript in preparation.
Impact Manuscript published.
Start Year 2014
 
Description Karolinska Institutet, SATSA group 
Organisation Karolinska Institute
Department Department of Medical Epidemiology and Biostatistics
Country Sweden 
Sector Academic/University 
PI Contribution The Karolinska team have contributed three replication analyses to a major study of the genetics of cognitive ageing being led by the Edinburgh team. Here, the major Karolinska contact is Prof Nancy Pederson. Dr Mike Allerhand, the Centre's employed statisitician, has contributed statistical expertise to this collaboration, on a study of the relationship between body mass and decline in cognitive functioning.
Collaborator Contribution Provision of data and analyses from The Swedish Adoption/Twin Study of Aging (SATSA). , and other ageing cohorts. Also, postdoctoral worker Dr Dahl has visited Edinburgh for three weeks, and other visits are planned.
Impact A paper is at the advcance draft stage prior to publication. The results were presented at the International Conference of Alzheimers Disease, and at other conferences. A visit by Dr Anna Dahl took place to CCACE for three weeks and longer visits are planned for 2012 and 2013.
Start Year 2011
 
Description MAGIC - international glycaemic traits genetics consortium 
Organisation MAGIC
Country United Kingdom 
Sector Public 
PI Contribution The is an international glycaemic traits genetics consortium. Current work is focussed on analysis of exome chip data.
Collaborator Contribution The is an international glycaemic traits genetics consortium. Current work is focussed on analysis of exome chip data.
Impact Manuscript in preparation.
Start Year 2014
 
Description MRC Centre for Analysis in Translational Epidemiology 
Organisation University of Bristol
Department MRC Centre for Causal Analyses in Translational Epidemiology
Country United Kingdom 
Sector Public 
PI Contribution MRC CAiTE Director, Professor George Davey Smith from Bristol, invited Ian Deary begin_of_the_skype_highlighting     end_of_the_skype_highlighting and the CCACE to be a formal collaborator with his Centre.
Collaborator Contribution Formal collaborations have been made between the two Centres which has resulted in new research.
Impact Members from each Centre are collaborating on new research topics and have papers in preparation with some published (18994662 18704700). This collaboration has also resulted in the CHIC consortium: see separate entry. 25201988 23722424 23358156. Davey Smith and senior members of his team are providing the expertise for a CCACE special interest day in epigenetics in November 2014 and Davey Smith is giving the CCACE St Andrew's Day lecture in 2014.
Start Year 2009
 
Description MRC Human Genetics Unit 
Organisation Medical Research Council (MRC)
Department MRC Human Genetics Unit
Country United Kingdom 
Sector Public 
PI Contribution The MRC Human Genetics Unit, Edinburgh, formally collaborates with the CCACE with two of its group being members of the CCACE. Dr Sarah Harris is the CCACE Geneticist and Professor Alan Wright is a full scientific member.
Collaborator Contribution Research collaborations have been made between CCACE members and MRC HGU staff.
Impact The HGU/CCACE collaboration formalises a long standing collaboration between Ian Deary, John Starr, and HGU staff. Since the inception of CCACE, the HGU have continued the generous practice of providing Sarah Harris with a desk in HGU which means that CCACE benefits from the rich genetic environment of HGU. This collaboration has produced a number of scientific papers. These include: 19397951 18855131 19776035 18317464 19077115 1820041 19418213 18493267 18946731 19290744 19077176 19821022 18977241 18628685 21194798 21840749
Start Year 2008
 
Description MRC Lifecourse Epidemiology Unit 
Organisation University of Southampton
Department MRC Lifecourse Epidemiology Unit
Country United Kingdom 
Sector Public 
PI Contribution MRC Epidemiology Resource Centre, Southampton, formally collaborates with the CCACE with one of its staff being a member of the CCACE. Dr Catherine Gale is a full scientific member of the CCACE. The Epidemiology Resource Centre is also part of the HALCyon collaboration, though the large majority of the CCACE-ERC joint publications arise from direct collaboration rather than through HALCyon.
Collaborator Contribution CCACE members and staff from the MRC LEU have collaborated on publications.
Impact This collaboration has produced a number of scientific papers. These include: 18235070 18204831 18525394 18801778 18477751 18594058 18718672 19147741 19189278 19344891 18947352 19907664 18480188 18380686 19047528 19047528 19907333 18812363 19864640 19907333 19483120 19706576 19321850 19251871 19955099 19047528 19864640 19907333 1838068619483120 19892320 19834050 20214846 Gale et al (2009). Intelligence 37;592-599; 21542061 21332924 21349224
Start Year 2008
 
Description MRC Population Health Sciences Research Network 
Organisation Medical Research Council (MRC)
Department MRC Population Health Sciences Research Network (PHSRN)
Country United Kingdom 
Sector Public 
PI Contribution Prof Deary is now a member of MRC Population Health Sciences Research Network representing CCACE. Prof Batty sometimes attends as Deary's deputy
Collaborator Contribution The MRC supports the network.
Impact Deary and Batty have applied to PHSRN for 7.5 thousand ponds to hold a 1-day international meeting on Cognitive Epidemiology: The Next Steps. The plan is for this to be a pre-meeting to the Society for Social Medicine conference in July 2012.
Start Year 2008
 
Description MRC Social and Public-Health Sciences Unit 
Organisation Medical Research Council (MRC)
Department MRC Social & Public Health Sciences Unit
Country United Kingdom 
Sector Public 
PI Contribution MRC Social and Public-Health Sciences Unit, Glasgow, formally collaborates with the CCACE with two of its staff being members of the CCACE. Dr David Batty from the Unit is the cognitive epidemiology group leader in the CCACE and Mr Geoff Der is a full scientific member. Update 2013: David Batty moved to UCL.
Collaborator Contribution Two staff members of the MRC SPHSU are now CCACE scientific members with one holding the role of group leader for cognitive epidemiology.
Impact This formal collaboration is one of the most productive in which the Centre engages. These include: 18235070 18204831 19043147 18525394 18801778 18477751 18594058 18718672 19147741 19189278 19602715 19234402 19344891 18947352 19290736 19907664 19047533 19907663 19572219 18480188 18380686 19047528 19047528 19907333 18812363 19907333 19483120 19861402 19706576 18704700 18655859 19251871 19955099 Roberts et al (2009) Intelligence 37;561-566 19572219 19907663 19955099 18204831 18235070 18477751 18525394 18594058 18718672 18801778 19043147 19047533 19147741 19189278 19234402 1920736 19602715 19468018 20190131 21969461 24747801 24365661 23375947
Start Year 2008
 
Description MRC Unit for Lifelong Health and Ageing 
Organisation University College London
Department MRC Unit for Lifelong Health and Ageing
Country United Kingdom 
Sector Public 
PI Contribution The CCACE hosted a cross-Centre meeting with the MRC LHA Centre which resulted in new research collaborations between members of both groups.
Collaborator Contribution Members from both groups are now collaborating on new research.
Impact New research into ageing is being carried out and will be published in the future with one joint paper already published (Richards, M., Black, S., Mishra, G., Gale, C. R., Deary, I. J., & Batty, G. D. (2009). IQ in childhood and the metabolic syndrome in middle-age: extended follow-up of the 1946 British Birth Cohort Study. Intelligence, 37, 567-572). Ian Deary is a formal collaborator on a LHA Wellcome grant. Further publications are already in preparation.
Start Year 2009
 
Description MacLullich - Edinburgh Delirium Test Box 2 
Organisation Johns Hopkins University
Country United States 
Sector Academic/University 
PI Contribution Design of the testing device and tests. Provide advice on testing procedures. Trained two MSc students who helped design the experiment and who carried out the data collection in the ICU.
Collaborator Contribution Implementation of the tests on a bespoke hardware device. The Medical Devices Unit is now going to write new software, which will be MHRA-compliant, for use on tablet PCs and smartphones.
Impact Poster presentation at an international conference (European Delirium Association) on the test. MRC Centenary Fund award, via CCACE, to Dr Zoe Tieges, the postdoctoral fellow working on the EDTB2 programme.
Start Year 2012
 
Description MacLullich - Edinburgh Delirium Test Box 2 
Organisation NHS Greater Glasgow and Clyde (NHSGGC)
Department Medical Devices Unit
Country United Kingdom 
Sector Public 
PI Contribution Design of the testing device and tests. Provide advice on testing procedures. Trained two MSc students who helped design the experiment and who carried out the data collection in the ICU.
Collaborator Contribution Implementation of the tests on a bespoke hardware device. The Medical Devices Unit is now going to write new software, which will be MHRA-compliant, for use on tablet PCs and smartphones.
Impact Poster presentation at an international conference (European Delirium Association) on the test. MRC Centenary Fund award, via CCACE, to Dr Zoe Tieges, the postdoctoral fellow working on the EDTB2 programme.
Start Year 2012
 
Description MacLullich - Edinburgh Delirium Test Box 2 
Organisation Royal Infirmary of Edinburgh
Department Intensive Care Unit (ICU)
Country United Kingdom 
Sector Hospitals 
PI Contribution Design of the testing device and tests. Provide advice on testing procedures. Trained two MSc students who helped design the experiment and who carried out the data collection in the ICU.
Collaborator Contribution Implementation of the tests on a bespoke hardware device. The Medical Devices Unit is now going to write new software, which will be MHRA-compliant, for use on tablet PCs and smartphones.
Impact Poster presentation at an international conference (European Delirium Association) on the test. MRC Centenary Fund award, via CCACE, to Dr Zoe Tieges, the postdoctoral fellow working on the EDTB2 programme.
Start Year 2012
 
Description MacLullich - Edinburgh Delirium Test Box 2 
Organisation University of Iowa
Country United States 
Sector Academic/University 
PI Contribution Design of the testing device and tests. Provide advice on testing procedures. Trained two MSc students who helped design the experiment and who carried out the data collection in the ICU.
Collaborator Contribution Implementation of the tests on a bespoke hardware device. The Medical Devices Unit is now going to write new software, which will be MHRA-compliant, for use on tablet PCs and smartphones.
Impact Poster presentation at an international conference (European Delirium Association) on the test. MRC Centenary Fund award, via CCACE, to Dr Zoe Tieges, the postdoctoral fellow working on the EDTB2 programme.
Start Year 2012
 
Description MacLullich - Edinburgh Delirium Test Box 2 
Organisation University of Pennsylvania
Country United States 
Sector Academic/University 
PI Contribution Design of the testing device and tests. Provide advice on testing procedures. Trained two MSc students who helped design the experiment and who carried out the data collection in the ICU.
Collaborator Contribution Implementation of the tests on a bespoke hardware device. The Medical Devices Unit is now going to write new software, which will be MHRA-compliant, for use on tablet PCs and smartphones.
Impact Poster presentation at an international conference (European Delirium Association) on the test. MRC Centenary Fund award, via CCACE, to Dr Zoe Tieges, the postdoctoral fellow working on the EDTB2 programme.
Start Year 2012
 
Description National Forum on Ageing Futures Group 
Organisation National Forum on Ageing Futures Group
Country United Kingdom 
Sector Academic/University 
PI Contribution The Centre's knowledge exchange officer, Dr Robin Morton, approached this group to explain the work of the Centre. They are now extremely interested in collaborating and hearing more on the types of research that the Centre carries out.
Impact Robin Morton has attended one meeting with this group which has raised the profile of the CCACE and the Centre is now known to this group. Ian Deary begin_of_the_skype_highlighting     end_of_the_skype_highlighting gave a keynote presentation at their 2009 national meeting. This was useful as there were many practitioners and policy makers there to hear the work of the Centre.
Start Year 2009
 
Description Network of Centres of Excellence in Neurodegeneration (COEN) 
Organisation German Centre for Neurodegenerative Diseases
Country Germany 
Sector Public 
PI Contribution MRC Centres of Excellence in Neurodegeneration. Worldwide collaborators in Germany, Italy, France, Canada, USA, Australia and the UK. Members of the COEN Network are contributing to further secondary analysis of imaging data from the ground-breaking Secondary Prevention of Small Subcortical Stroke (SPS3) trial led by Oscar Benavente (Vancouver, PI, COEN expert), with exchange of fellows between Edinburgh and Vancouver.
Collaborator Contribution International experts in neuro-imaging of ageing, small vessel disease, neurodegeneration and methodology of multimodel MRI across sites.Multiple skill sets of collaborators including small vessel disease; dementia, stroke and brain atrophy; MR physics sequence development for neuroimaging. Members of the COEN Network are contributing to further secondary analysis of imaging data from the ground-breaking Secondary Prevention of Small Subcortical Stroke (SPS3) trial led by Oscar Benavente (Vancouver, PI, COEN expert), with exchange of fellows between Edinburgh and Vancouver.
Impact COEN grant consortium established standards to SVD across two workshops in 2012. Main paper published 2013. A research fellow from Maastricht (COEN participant van Oostenbrugge) visited Edinburgh and performed further development of individual SVD features into a total sum score. One paper published (see publications) and one paper in review, publication pending.
Start Year 2010
 
Description Network of Centres of Excellence in Neurodegeneration (COEN) 
Organisation University of Calgary
Department Department of Clinical Neurosciences
Country Canada 
Sector Academic/University 
PI Contribution MRC Centres of Excellence in Neurodegeneration. Worldwide collaborators in Germany, Italy, France, Canada, USA, Australia and the UK. Members of the COEN Network are contributing to further secondary analysis of imaging data from the ground-breaking Secondary Prevention of Small Subcortical Stroke (SPS3) trial led by Oscar Benavente (Vancouver, PI, COEN expert), with exchange of fellows between Edinburgh and Vancouver.
Collaborator Contribution International experts in neuro-imaging of ageing, small vessel disease, neurodegeneration and methodology of multimodel MRI across sites.Multiple skill sets of collaborators including small vessel disease; dementia, stroke and brain atrophy; MR physics sequence development for neuroimaging. Members of the COEN Network are contributing to further secondary analysis of imaging data from the ground-breaking Secondary Prevention of Small Subcortical Stroke (SPS3) trial led by Oscar Benavente (Vancouver, PI, COEN expert), with exchange of fellows between Edinburgh and Vancouver.
Impact COEN grant consortium established standards to SVD across two workshops in 2012. Main paper published 2013. A research fellow from Maastricht (COEN participant van Oostenbrugge) visited Edinburgh and performed further development of individual SVD features into a total sum score. One paper published (see publications) and one paper in review, publication pending.
Start Year 2010
 
Description Normative Brain Image Bank - Ian Deary/ Joanna Wardlaw 
Organisation University of Aberdeen
Country United Kingdom 
Sector Academic/University 
PI Contribution Normative Brain Image Bank: with Aberdeen, Glasgow, Dundee in creation of a normative brain image bank across the life course but specifically for older ages; including external collaboration with UCSF, California (Toga), Montreal Neurological Institute (Evans), Paris (Poline) -JM Wardlaw, M Bastin, I Deary).
Collaborator Contribution The groups have all brought data and expertise to the project.The groups have all brought data and expertise to the project.The groups have all brought data and expertise to the project.
Impact The project is ongoing with the plan that it will create a bank of brain images. Grant application submitted.
Start Year 2010
 
Description Normative Brain Image Bank - Ian Deary/ Joanna Wardlaw 
Organisation University of Dundee
Country United Kingdom 
Sector Academic/University 
PI Contribution Normative Brain Image Bank: with Aberdeen, Glasgow, Dundee in creation of a normative brain image bank across the life course but specifically for older ages; including external collaboration with UCSF, California (Toga), Montreal Neurological Institute (Evans), Paris (Poline) -JM Wardlaw, M Bastin, I Deary).
Collaborator Contribution The groups have all brought data and expertise to the project.The groups have all brought data and expertise to the project.The groups have all brought data and expertise to the project.
Impact The project is ongoing with the plan that it will create a bank of brain images. Grant application submitted.
Start Year 2010
 
Description Normative Brain Image Bank - Ian Deary/ Joanna Wardlaw 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution Normative Brain Image Bank: with Aberdeen, Glasgow, Dundee in creation of a normative brain image bank across the life course but specifically for older ages; including external collaboration with UCSF, California (Toga), Montreal Neurological Institute (Evans), Paris (Poline) -JM Wardlaw, M Bastin, I Deary).
Collaborator Contribution The groups have all brought data and expertise to the project.The groups have all brought data and expertise to the project.The groups have all brought data and expertise to the project.
Impact The project is ongoing with the plan that it will create a bank of brain images. Grant application submitted.
Start Year 2010
 
Description Pendleton - University of Manchester 
Organisation University of Manchester
Department School of Medicine Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of DNA phenotypes, computing, infrastructure, statistical analysis, paper writing.
Collaborator Contribution Subject samples with DNA and cognitive phenotypes
Impact 21826061 24975275 24626473 24344862 24342994 24246418. Plus many talks by Prof Deary and members of the collaboration: including a keynote address by Prof Deary to the International Conference on Alzheimer's Disease in Paris in 2011. Other publications are submitted and in preparation.
Start Year 2008
 
Description Peter Visscher group - University of Queensland 
Organisation University of Queensland
Department Queensland Institute of Medical Research
Country Australia 
Sector Academic/University 
PI Contribution Provided cohorts with phenotypic data and genetic information, plus analysis. This was formally the collaboration with Queensland Institute of Medical Research.
Collaborator Contribution Provided cohorts with phenotypic data and genetics information, plus analysis.
Impact Publications have now arisen: PMIDs: 25249537, 25201988, 23732877, 23419543, 23358156, 23207651, 22832902, 22703881, 22700061, 22258510, 21826061, 1559497, 20303064, 19944402, 19290744, 19077176, 9077115, 18946731, 18493267, 24944428, 24554214, 23732877
Start Year 2008
 
Description Plomin - MRC Social and Developmental and Genetic Psychiatry Centre 
Organisation King's College London
Department MRC Social Genetic and Developmental Psychiatry Centre (SDGP)
Country United Kingdom 
Sector Academic/University 
PI Contribution Samples with genetic and cognitve data, statistical anaysis, writing of papers.
Collaborator Contribution Twin samples with genetic and cognitive data
Impact Publications: 18493267. Prof Plomin from this collaboration is a Co-PI with Prof Deary on the childhood intelligence GWAS consortium. paper: 25224258 25201988 23358156
Start Year 2008
 
Description Policy Impact Knowledge Exchange Network (PIKEN) 
Organisation University of Edinburgh
Department Policy Impact Knowledge Exchange Network (PIKEN)
Country United Kingdom 
Sector Academic/University 
PI Contribution The Policy Impact Knowledge Exchange Network (PIKEN) is an Edinburgh based group which brings together over 50 early career researchers from universities, local and national government and the third sector to discuss the use of research in policy making in Scotland. The CCACE scientific administrator, Dr Beverly Roberts, was awarded a place on this network to investigate how the CCACE's health research could be translated into health policy.
Impact Beverly Roberts has attended a series of 5 workshops throughout 2009 and is an active part of the discussion group.
Start Year 2009
 
Description Prof Harald Mischak University of Glasgow 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution We collaborate with Prof. Harald Mischak at the University of Glasgow in 2010 to perform a proteomics study. A paper has been submitted.
Collaborator Contribution Professor Mischak provided expertise.
Impact The following paper has appeared: Lopez et al (2011) Intelligence, 39, 46-53. A grant was submitted to the Dunhill Trust. It was shortlisted but not funded. A further grant is being prepared for the Chief Scientist Office of the Scottish Govenment's health Directorates.
Start Year 2010
 
Description Scottish Data Linkage and Sharing Service / NRS 
Organisation Government of Scotland
Department Data Sharing and Linkage Service (DSLS)
Country United Kingdom 
Sector Public 
PI Contribution The research team contributed expertise in cognitive epidemiology and feedback on our experiences of data linkage. Ultimately the team will contribute data from the Scottish Mental Survey 1947. The team also suggested a suitable consultant for completion of a scoping project, and hosted and supervised that consultant for the duration of the 3-month project.
Collaborator Contribution The NRS team will contribute linkage between SMS1947 and National Registration 1939 databases. Funds were provided for consultancy work as part of a scoping project to identify suitable databases for linkage.
Impact The linkage between SMS1947 and 1939 national registration databases will enhance the tracing of the SMS1947 group. The scoping project led to the production of an extensive report on the use of the SMS1947 as a 'pathfinder' project for the new Data Sharing and Linkage Service currently under development in Scotland.
Start Year 2013
 
Description Scottish Data Linkage and Sharing Service / NRS 
Organisation National Records of Scotland
Country United Kingdom 
Sector Public 
PI Contribution The research team contributed expertise in cognitive epidemiology and feedback on our experiences of data linkage. Ultimately the team will contribute data from the Scottish Mental Survey 1947. The team also suggested a suitable consultant for completion of a scoping project, and hosted and supervised that consultant for the duration of the 3-month project.
Collaborator Contribution The NRS team will contribute linkage between SMS1947 and National Registration 1939 databases. Funds were provided for consultancy work as part of a scoping project to identify suitable databases for linkage.
Impact The linkage between SMS1947 and 1939 national registration databases will enhance the tracing of the SMS1947 group. The scoping project led to the production of an extensive report on the use of the SMS1947 as a 'pathfinder' project for the new Data Sharing and Linkage Service currently under development in Scotland.
Start Year 2013
 
Description Scottish Dementia Clinical Research Network 
Organisation Alzheimer Scotland
Department Scottish Dementia Clinical Research Network
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution CCACE co-Director, Professor John Starr, has formed a collaboration with the Scottish Dementia Clinical Research Network to form a joint CCACE/Alzheimer Scotland Clinical Training Fellowship for Tom Russ who is a CCACE Associate Member. The Centre's contributions and activities with respect to this collaboration can be updated by going to http://www.sdcrn.org.uk/.
Collaborator Contribution Helped put together a Clinical Training Fellowship for a CCACE Associate Member. http://www.sdcrn.org.uk/
Impact The fellowship has begun this year and Centre members through Professor Starr now have easier access to subjetcs with dementia for their research. http://www.sdcrn.org.uk/
Start Year 2009
 
Description Scottish Longitudinal Study / NRS 
Organisation National Records of Scotland
Country United Kingdom 
Sector Public 
PI Contribution Childhood intelligence and family size data from the Scottish Mental Survey 1947 was provided for linkage to data held within the Scottish Longitudinal Study.
Collaborator Contribution Collaborators at the National Records of Scotland are tracing individuals in the Scottish Mental Survey 1947 and locating their 1939 registration number.
Impact This work is ongoing with no reportable outputs to date. The collaboration is multi-disciplinary, involving individuals from psychology, geography, sociology and within the National Records of Scotland.
Start Year 2012
 
Description Scottish Longitudinal Study / NRS 
Organisation University of St Andrews
Department Scottish Longitudinal Study
Country United Kingdom 
Sector Academic/University 
PI Contribution Childhood intelligence and family size data from the Scottish Mental Survey 1947 was provided for linkage to data held within the Scottish Longitudinal Study.
Collaborator Contribution Collaborators at the National Records of Scotland are tracing individuals in the Scottish Mental Survey 1947 and locating their 1939 registration number.
Impact This work is ongoing with no reportable outputs to date. The collaboration is multi-disciplinary, involving individuals from psychology, geography, sociology and within the National Records of Scotland.
Start Year 2012
 
Description Scottish Parliament Cross-Party Group on Older People Age and Ageing 
Organisation Scottish Parliament
Department Scottish Parliament Cross Party Group on Older People Age & Ageing
Country United Kingdom 
Sector Public 
PI Contribution On the basis of its research focus the CCACE was invited to join the Scottish Parliament Cross Party Group on Older People Age and Ageing which discusses Scottish Government policy relating to older adults. The group is convened by Sandra White MSP and George Foulkes MSP. The CCACE knowledge transfer officer, Dr Robin Morton, is the active contact with this group.
Impact The CCACE has attended one meeting of the group to date, and these have continued regularly and future meetings are in Prof Deary's diary. At the last meeting in August 2011, Prof Deary made a presentation on the work of CCACE to Scottish MSPs and leading members of ageing charities in Scotland.
Start Year 2009
 
Description Shenkin - BraINS (Brain Imaging in Normal Subjects) 
Organisation University of Edinburgh
Department Brain Research Imaging Centre
Country United Kingdom 
Sector Academic/University 
PI Contribution collaboration with multidisciplinary staff in Scottish Brain Imaging Centre (SBIRC) (neuroradiologists, image data managers, information technologists) to develop a searchable bank of normal brain images collected from previous research studies (several conducted by members of CCACE in geriatric medicine, psychology and psychiatry). No funding at present (application to CSO rejected, but encouraged international collaboration to set up resource).
Collaborator Contribution As above.
Impact No outputs yet. Aim is to develop a searchable database, and ultimately expand to an international, on-line, searchable resource.
Start Year 2011
 
Description Shenkin - Dementia and Delirium Implementation Group 
Organisation NHS Lothian
Department Geriatric Medicine
Country United Kingdom 
Sector Hospitals 
PI Contribution Member of Dementia and Delirium Implementation Group (NHS Lothian, UK) since 2009. Working towards improving the care of patients with dementia and delirium in NHS Lothian using audit, education and patient experience.
Collaborator Contribution Member of a working group.
Impact Documentation of diagnosis of dementia and delirium has improved. Delirium screening embedded in new admission document.
Start Year 2009
 
Description Shenkin - Lothian Dementia Strategy Implementation and Monitoring Group 
Organisation NHS Lothian
Department Geriatric Medicine
Country United Kingdom 
Sector Hospitals 
PI Contribution Group member.
Collaborator Contribution Developing and implementing strategy to improve care of patients with dementia in community and hospital.
Impact Improve care of dementia patients.
Start Year 2010
 
Description Sherif Karama - McGill University, Montreal 
Organisation McGill University
Department Montreal Neurological Institute and Hospital
Country Canada 
Sector Hospitals 
PI Contribution We provided brain imaging data and cognitive phenotypes.
Collaborator Contribution They analysed our brain imaging data for brain cortical thickness and conducted statistical analyses.
Impact Published papers and papers in progress. Pub med IDs: 23732878, 21241809
Start Year 2008
 
Description Software Sustainability Institute (SSI) 
Organisation University of Edinburgh
Department UK Software Sustainability Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaborative project to devise a sustainability plan for the release, support, maintenance and ongoing development of MCMxxxVI (MC Valdés Hernández and JM Wardlaw)
Collaborator Contribution Devise a sustainability plan for the release, support, maintenance and ongoing development of MCMxxxVI.
Impact Sustainable cataloged software for other academics to use, will be available online soon.
Start Year 2010
 
Description Telomere Phenomics Consortium 
Organisation Telomere Consortium
Country Global 
Sector Academic/University 
PI Contribution The Telomere Phenomics Consortium aims to enhance the quality of the evidence relating (or not) telomere length to cardiovascular risk factors and cardiovascular/overall outcome by combining data from high quality studies which share phenotypes, beyond initial publications of such data. The aim is not to compete against or supersede such primary publications but to subsequently reinforce findings through meta-analysis. The Lothian Birth Cohort 1936 data which is held in Edinburgh has been added to this consortium. The CCACE geneticist, Dr Sarah Harris, leads this collaboration.
Collaborator Contribution They have brought data and expertise.
Impact Data across Centres are being amalgamated and joint analyses are currently being completed.
Start Year 2008
 
Description The Maastricht Aging Study 
Organisation Maastricht University (UM)
Department Maastricht School for Mental Health and Neuroscience (MHeNS)
Country Netherlands 
Sector Academic/University 
PI Contribution Dr Martin van Boxtel and Olga Schiepers from the Maastricht Aging Study visited the CCACE for a 2-day scientific meeting to investigate possible collaborations on cognitive ageing with various Centre members.
Collaborator Contribution Formal collaborations between member sof both groups have been made.
Impact Formal collaborations were made and Olga Schiepers visited the CCACE for 3 months in early 2010 to carry out some collaborative research, and has kept in touch throughout 2011. Detailed plans for Schiepers to work on the Lothian Birth Cohort 1936 data were veery successful and two papers have resulted: Schiepers et al (2011), Molecular Psychiatry, in press PUBMED no. 21263443; Schepers et al (2011) Genes, Brain and Behavior, 10, 354-364.
Start Year 2009
 
Description Toshiba Medical Visualisation Systems 
Organisation Toshiba Medical Visualisation Systems
Country United Kingdom 
Sector Private 
PI Contribution - Supervising student project on a comparison of 4 unsupervised clustering algorithms for segmenting brain tissue in multi-spectral MR data. - Discussions are ongoing with Toshiba Medical Visualisation Systems regarding development of normative brain atlases and potential development of image processing tools.
Collaborator Contribution - Plans to develop normative brain atlases and potentially image processing tools. - ED student of the Institute for System Level Integration collaboratinmg for 2x8 weeks
Impact Talk at BIOSTEC 2010 (Third International Joint Conference on Biomedical Engineering Systems and Technologies).
Start Year 2008
 
Description University of Chichester 
Organisation University of Chichester
Department Department of Psychology and Counselling
Country United Kingdom 
Sector Academic/University 
PI Contribution Data discovery, analysis and co-authorship
Collaborator Contribution Data analysis and co-authorship
Impact ESRC Fellowship for Sophie Von Stumm. Publications: Von Stumm et al: (2010) Intelligence 38;202-211; Intelligence, 39, 161-167; Journal of Child Psychology and Child Psychiatry, 52, 992-1001.
Start Year 2011
 
Description University of Oslo 
Organisation University of Oslo
Department Department of Psychology
Country Norway 
Sector Academic/University 
PI Contribution Together the team has contributed gentoyping and cognitive phenotyping information on their respective cohorts to contribute to joint publicaitons and to make future plans for genetics studies and cognitive and brain ageing.
Collaborator Contribution This is a collaboration with the University of Oslo in bringing together an international group based in the Centre for Advanced Study in Oslo, Norway. The Oslo collaborators provided travel and subsistance for the Edinburgh team and also some funding for post-doctoral staff wages (still to be drawn).
Impact Davies et al (2011) Molecular Psychiatry, 16, 996-1005. Also, workshops in Bergen and Oslo in 2011, with further meetings planned for 2012. Post-doctoral exchange visits have taken place and are planned.
Start Year 2008
 
Description University of Queensland - genome-wide methylation study 
Organisation University of Queensland
Country Australia 
Sector Academic/University 
PI Contribution LBC1936 and LBC1921 DNA samples were typed using the Illumina HumanMethylation450 BeadChip at the Wellcome Trust Clinical Research Facility (WTCRF). Quality control of the data was performed at the University of Queensland and analyses are ongoing at both CCACE and the University of Queensland.
Collaborator Contribution See above. Quality control of the data was performed at the University of Queensland.
Impact The following paper has been published: Shah S, McRae AF, Marioni RE, Harris SE, Gibson J, Henders AK, Redmond P, Cox SR, Pattie A, Corley J, Murphy L, Martin NG, Montgomery GW, Starr JM, Wray NR, Deary IJ, Visscher PM. (2014). Genetic and environmental exposures constrain epigenetic drift over the human life course. Genome Res doi:10.1101/gr.176933.114.
Start Year 2012
 
Description fMRI studies - Jack Nissan 
Organisation University of Edinburgh
Department Clinical Research Imaging Centre
Country United Kingdom 
Sector Academic/University 
PI Contribution The CCACE Human Testing Technician has contributed to two fMRI studies: 1) fMRI study on musical learning strategies. (Study ongoing) - year started: 2010 2) fMRI study on Motor imagery and ageing (Study ongoing) - year started: 2010 Study 1 - wrote the computer code for the fMRI paradigm. Study 2 - Co-designed the experiment and test battery, and wrote the computer code for the fMRI paradigm.
Collaborator Contribution see above
Impact Expected publications from the studies. Acquisition of transferrable skills for CCACE Human Testing Technician, Mr Jack Nissan, with regard to fMRI software and fMRI procedures at the Clinical Research in Imaging Centre (CRIC). As a result of these collaborations, Jack Nissan will act as a contact point for others within CCACE who wish to carry out fMRI studies at CRIC.
Start Year 2010
 
Title A Tiny Handbook of R 
Description CCACE Statistician has written "A Tiny Handbook or R", which was published by Springer in 2011. 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2011
Licensed Yes
Impact The book has achieved sales of over 170 copies since publication in April 2011. Sample pages from the handbook, published on the Springer website, have been downloaded 634 times in the last 90 days. The handbook is also being used in a course on Data Analysis, Forecasting and Risk Analysis in Washington University in St Louis.
 
Title Deary-Liewald Reaction Time Task 
Description Developed by CCACE Director, Professor Ian Deary, and CCACE database manager, Mr Dave Liewald, a newly developed computerised reaction time task will be made freely available via the CCACE website. The computer programme includes a simple reaction time task, in which the participant has to respond to a single stimulus, and a four choice reaction time task, in which the participant has to chose from four possible responses. In 2011 CCACE developed and published an updated version (v3.10) with additional features to enhance its usability. 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Initial development
Year Development Stage Completed 2009
Development Status Under active development/distribution
Impact Since 2011 the device has been made freely available on the CCACE website: www.ccace.ed.ac.uk. The programme has received >170 Downloads and is in routine use as a research tool in a number of centres globally. In Scotland, it is being used in the population-based study Generation Scotland: Scottish Family Health Study and in the Edinburgh Type II Diabetes Study. 
URL http://www.ccace.ed.ac.uk
 
Title Deary-Liewald Reaction Time Task - Ian Deary, Dave Liewald 
Description Developed by CCACE Director, Professor Ian Deary, and CCACE database manager, Mr Dave Liewald, a newly developed computerised reaction time task is freely available via the CCACE website. The computer programme includes a simple reaction time task, in which the participant has to respond to a single stimulus, and a four choice reaction time task, in which the participant has to chose from four possible responses. A child version of reaction time task has recently been developed and used in the Edinburgh Science Festival. 
Type Of Technology Software 
Year Produced 2009 
Open Source License? Yes  
Impact The device is being used by the large population study Generation Scotland: Scottish Family Health Study. A paper describing the methodology is now in press. In 2011 CCACE developed and published an updated version (v3.10) with additional features to enhance its usability. The programme has received several hundred downloads and is in routine use as a research tool in a number of centres globally. In Scotland, it is being used in the population-based study Generation Scotland: Scottish Family Health Study and in the Edinburgh Type II Diabetes Study. Mr Jack Nissan, CCACE's Human Testing Technician provides training of this research tool to the cohort studies. 
 
Title Iron Deposits Segmentation Guidlines 
Description Detailed guidelines (manual) to use the software package Analyze 9.0 to identify and quantify brain microbleeds and hemosiderin deposits in T2*-weighted MR sequences. Uploaded to the internet in December 2009. 
Type Of Technology New/Improved Technique/Technology 
Year Produced 2009 
Impact Novel MRI analysis tool, suitable for large samples. 
 
Title R package to implement Thomson's bonds model 
Description The Centre's statistician, Dr Mike Allerhand, developed an R package in order to implement the Bonds theory of intelligence first proposed by Godfrey Thomson. It has been described in: Bartholomew D. J, Allerhand M., Deary I. J., (2013). Measuring mental capacity: Thomson's bonds model and Spearman's g-model compared. Intelligence. 41:222-233. 
Type Of Technology Software 
Year Produced 2013 
Open Source License? Yes  
Impact The package is distributed open source through the Centre's website. 
 
Title Software MCMxxxVI 
Description This software implements the Multispectral Colouring Modulation and Variance Identification method developed in the SFC Brain Image Research Centre for doing the Tissue Segmentation and Volume Analysis in MR images and incorporates some post-processing tools important for displaying and calculating the statistics of the features segmented. Four modules were uploaded to the internet in December 2009 (as open source software). 
Type Of Technology Software 
Year Produced 2009 
Open Source License? Yes  
Impact Novel MRI analysis technique, suitable for large samples. 
 
Company Name NeurocentRx Pharma Ltd 
Description NeurocentRx Pharma Ltd.™ was founded in 2008 by 14 academics with renowned scientific and clinical teams from the University of Edinburgh, with Dr Ron Lindsay (Regeneron, Millennium) as Chairman, Dr Howard Marriage (Genzyme, Cyclacel) as CEO, and with key pharma / biotech business veteran advisors. NeurocentRx™ aims to be an innovative company that will harness the translational insight of the University's leading researchers to enhance the development of neuroscience medicines in the key areas of cognition, psychiatry and pain. Leading scientific insight is provided by the internationally renowned academic teams of Professors Jonathan Seckl (CCACE co-Director), David Porteous (CCACE Group Leader), Douglas Blackwood, Sue Fleetwood-Walker and Malcolm Walkinshaw. The NeurocentRx starting structure provides opportunities for multiple possible academic and partnering interactions and involvements in an open architecture model that seeks to match the best early projects with enthusiasm to the best available and experienced care. 
Year Established 2008 
Impact 1) Initial Portfolio in Psychiatry, Pain & Cognition, New Drug Targets For Schizophrenia Prof. David Porteous (CCACE Group Leader), Prof. Douglas Blackwood, Dr. Walter Muir, Dr. Ben Pickard Discovery and Validation Stage - DISC-1 Gene and Down Stream Targets Human genetics driven discovery and validation stage project - World class and well funded academic project to define the molecular basis of schizophrenia through population genetic studies in Scotland. Project lead by Prof David Porteous & Douglas Blackwood has already lead to identification (and wide publicity) of the first gene defect associated with schizophrenia - DISC 1. Working closely with this group, NeurocentRx plans to make this a flagship discovery and target validation project that will be the centerpiece of a major collaborative program with a global Pharma company. 2) Novel Validated Target for Neuropathic Pain Prof. Susan Fleetwood-Walker, Prof. Marie Fallon, Prof. Lesley Colvin, Dr. Rory Mitchell, Dr. Mike Greaney Preclinical Stage and clinical - Small Molecule Agonists of TRP-M8 Lead molecule validated in animal models - Based on a seminal discovery of Prof. Fleetwood- Walker and colleagues, it appears that activation of the non-selective cation channel TRP-M8 may be something of master switch in quelling chronic neuropathic pain (pain associated with direct nerve damage such as injury, diabetes, surgery etc) . An analgesia program based on TRP-M8 and possibly other pain targets, will be the initial internal centerpiece of an internal pain program at NeurocentRx. 3) New Approach for the Treatment of Cognitive Disorders Prof. Jonathan Seckl (CCACE co-Director)) & Prof. Alasdair MacLullich (CCACE Group Leader) Pre-IND Stage - Inhibitors of 11beta HSD1 - Use of Off-Patent Drug with Follow-On Potential 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is an intracellular amplifier of glucocorticoid action. By converting intrinsically inert glucocorticoids (cortisone, 11-dehydrocorticosterone) into their active forms (cortisol, corticosterone), 11beta-HSD1 increases glucocorticoid access to receptors. Glucocorticoid hormones modulate diverse physiological processes, linking circadian rhythms to food seeking, motivational and cognitive behaviors, as well as intermediary metabolism and immune responses. A novel clinical trial program is being designed that may, be a forerunner for testing an existing class of drug in an acute cognitive impairment setting prior to trials in Alzheimer's disease.
 
Description Talk at Age UK's Edinburgh and Lothians Meeting of Older People's Groups and Organisations and presentation on healthy ageing - Michelle Luciano 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Afternoon of talks and workshops about healthy ageing with people who help to organise activities and meetings for older people. The talks were focused on healthy ageing and top tips for staying sharp, based on evidence from the Lothian Birth Cohort studies.

The attendees reported that they would try to introduce new activities into their groups, including crafting, walking, book clubs, educational programmes.

Personal feedback included: "I will try and cut down sweets and pudding intake"; "Improve sleep, keep hydrated, and get back to daily run"; "Attempt to learn French"
Year(s) Of Engagement Activity 2018
 
Description 'Dementia Diaries', performance and Q&A 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact In April 2011 the Centre hosted a theatre performance in Edinburgh entitled "Dementia Diaries". Representing the CCACE and the Scottish Dementia Clinical Research Network, Dr Tom Russ was part of a discussion panel after both performances of this play, which involved discussing the play itself and answering questions from the audience.

'Dementia Diaries' which attracted an audience of over 200 people from a variety of backgrounds. Around one third of those attending worked in public, social or health services and feedback indicated that they had learned something from the event and that the information provided about the Lifelong Health and Wellbeing Centre was useful.
Year(s) Of Engagement Activity 2011
 
Description 'I'm a Scientist get me out of here' - Andy MacLeod 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Schools
Results and Impact CCACE Geneticist and Statistician Andy MacLeod came 2nd in the Healthy Ageing zone of IAS2011

Andy answered questions on science and spoke about his experience as a scientist to Schools around the UK via online chat and offline questions
Year(s) Of Engagement Activity 2011
 
Description 14th Annual Meeting of the British Chapter of ISMRM 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Oral Presentation by invited speaker Dr. Mark E. Bastin, presenting:. "White Matter Integrity and Cognitive Ability in Youth and Old Age: Interim Results from the LBC1936 Study" by Bastin ME, Penke L, Murray C, Muñoz Maniega S, Valdes Hernandez MC, Gow A, Wardlaw JM, Deary IJ.

Interest shown by the participants
Year(s) Of Engagement Activity 2008
 
Description ARUK donor talk - Riccardo Marioni 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact • Alzheimer's research communication to ~20 trustees and donors of Alzheimer's Research UK (Oct 2018)
Year(s) Of Engagement Activity 2018
 
Description Ageing brain, ageing mind. Senior men's group - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Presentation about cognitive and brain ageing for a senior men's group, followed by questions and discussion.
Year(s) Of Engagement Activity 2018
 
Description Ageing intervention research at HWU - Alan Gow 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Third sector organisations
Results and Impact Ageing intervention research at HWU. Roundtable presentation to Age Scotland, Heriot-Watt University, Edinburgh, UK, 27th March 2018.
Local/national reach - impact was in developing new networks and connections between researchers in ageing/brain health at HWU and national charity partner (Age Scotland).
Year(s) Of Engagement Activity 2018
 
Description Alzheimer's research communication - Riccardo Marioni 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact Alzheimer's research communication to ~20 trustees and donors of Alzheimer's Research UK (Oct 2018), and also to two final-year high school students preparing projects on genetics (June/Oct 2018).
Year(s) Of Engagement Activity 2018
 
Description BBC Filming of Dementia Buddies Scheme 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The BBC came to our research facility and filmed us having conversations with patients about their lived experience with dementia. We also gave the patients a tour of the facility and a seminar on our work.

The footage was shown on BBC Scotland TV, radio and bbc.co.uk.

Many people got in touch afterwards looking to take part.
Year(s) Of Engagement Activity 2018
URL https://www.bbc.co.uk/news/uk-scotland-edinburgh-east-fife-46589662
 
Description BBC Radio Scotland Brainwaves: How To Stay Sharp - Alan Gow 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Alan Gow contributed to the BBC Radio Scotland programme Brainwaves, presented by Pennie Latin (broadcast 7 and 11 February 2018). Alan discussed lifestyle factors that contribute to healthy cognitive ageing.
Year(s) Of Engagement Activity 2018
URL http://www.bbc.co.uk/programmes/b09qqmfg
 
Description BBC Radio Scotland Personal Best : Giving and Receiving - Alan Gow 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Alan Gow contributed to the BBC Radio Scotland programme Personal Best, presented by Gillian Russell (broadcast 17 and 22 December 2018). The programme explored the topics of health and wellbeing.
Year(s) Of Engagement Activity 2018
URL https://www.bbc.co.uk/programmes/m0001mxz
 
Description BBC Radio Scotland Personal Best: Couples' Coaching Cards & Growth Mindset - Alan Gow 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Alan Gow contributed to the BBC Radio Scotland programme Personal Best, presented by Gillian Russell: Couples' Coaching Cards & Growth Mindset (broadcast 12 and 17 February 2018). Alan Gow described the of impact different activities on thinking skills in older age.
Year(s) Of Engagement Activity 2018
URL http://www.bbc.co.uk/programmes/b09rk6s7
 
Description BBC Radio Scotland interview - Riccardo Marioni 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact BBC Radio Scotland live interview with Riccardo Marioni to discuss his study that identified 3 new genes associated with Alzheimer's disease (May 2018).
Year(s) Of Engagement Activity 2013,2015,2018
 
Description BBC The Twinstitute - Thomas Bak 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact BBC Show "The Twinstitute" participation with TH Bak. Carried out cognitive testing post-course and brief appearance in the show.
Year(s) Of Engagement Activity 2019
URL https://twitter.com/EdinUniCAHSSres/status/1093182434185801728
 
Description BBC Trust me I'm a doctor - Thomas Bak 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Carried out cognitive testing and actively participated and contributed to research for the BBC programme "Trust me I am a doctor" alongside my research colleagues. Appearance in the show.
Year(s) Of Engagement Activity 2018
URL https://twitter.com/BBCTrustMe/status/1037415820392116224
 
Description Being smart and staying smart - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Presentation 'Being smart and staying smart' to the Genetics and Genomics Principal Investigators' Group, Roslin Institute, University of Edinburgh. Edinburgh, UK, July 2018.
Year(s) Of Engagement Activity 2018
 
Description Brain Imaging and Society - what are we thinking and who has a right to know 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact CCACE co-sponsored a series of debates to explore the ethical impact of neuroimaging on society. The series called "Brain Imaging and Society - what are we thinking and who has a right to know" is taking place at the Institute for Advanced Studies in Glasgow. Neuroimaging has advanced such that functional magnetic resonance imaging can reveal explicitly an individual's thought patterns. This raises ethical and practical questions that society needs to address.


By stimulating debate and gathering opinion between the general public, societal groups (patients, prisoners), scientists, clinicians, ethicists, legal experts and politicians, this programme raised awareness of privacy and ethical issues, determine a cross-section of opinion, and through engagement of users and policy makers, publish reports to guide policy outcomes.
Year(s) Of Engagement Activity 2010
 
Description Brain Training on Trial - Alan Gow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Presentation exploring issues related to the brain training industry, at the Edinburgh Festival Fringe as part of Skeptics on the Fringe, Edinburgh Skeptics Society, Edinburgh, UK, 20th August 2018.
Year(s) Of Engagement Activity 2011,2018
 
Description Bright Club - Andy MacLeod 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact CCACE Geneticist Andy MacLeod performed a standup comedy show at the BBC Bubble, part of the Edinburgh Festival Fringe, about his job as a Statistical Geneticist

The show was enjoyed by over 300 people, predominantly members of the public.
Year(s) Of Engagement Activity 2011
 
Description Bringing intelligence to life - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Bringing intelligence to life. Invited address to the Human Genetics Group, Wellcome Genome Campus, Hinxton, Cambridge. Cambridge, UK, March 2018.
Year(s) Of Engagement Activity 2018
 
Description British Academy Lecture - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Centre Director Professor Deary delivered the British Academy Lecture on "Healthy mental ageing: grey matters and white matters too!" at the University of Newcastle, Newcastle-Upon-Tyne UK, in January 2011.

General positive feedback and increased awareness of research work to a wide range of health professionals and policy makers.
Year(s) Of Engagement Activity 2011
 
Description British Council meeting - John Starr, Alasdair MacLullich 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Two CCACE members, Co-Director Professor John Starr and Group Leader Professor Alasdair MacLullich were invited to give a series of lectures in Seville on behalf of the CCACE on "Ageing and Life Expectancy". The event was sponsored by the British Council and involved around 100 lay and press individuals.

Professor Starr - Invited to write a journal article on the topic and both CCACE members were interviewed by by Radio Exterior de Espana which is the equivalent of the BBC World Service.
Year(s) Of Engagement Activity 2009
 
Description CCACE - Artist collaboration article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact The Psycholigts is sent to all membes of the British Psychologyical Society, so will be seen by a number that tsretches in to 6 figures.

Because of wide circulation, this will be seen by tens of thousands or over 100,000 people who will see the collaboration between the Centre's science and the portrait artist.
Year(s) Of Engagement Activity 2013
 
Description CCACE - Edinburgh International Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Edinburgh International Science Festival Activity - University of Edinburgh Family Drop in Events, National Museum of Scotland April 2010, 2011 and 2012.

Approx 2,500 visitors each year. The attendees were able to take part in assessments of thinking skills that are affected by ageing. They found this fun as well as instructive and led to useful discussions about how the brain ages.
Year(s) Of Engagement Activity 2011,2012
 
Description CCACE - Ednburgh International Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact 3000 people visited a CCACE stand on how we measure the brain at the Edinburgh International Science Festival.

Enthusiastic response to materials, many questions, and obvious intense interest in the Centre on cognitive ageing and cognitive epidemiology.
Year(s) Of Engagement Activity 2013
 
Description CCACE - Get Up and Go Awards 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact CCACE sponsored Get Up and Go Awards. Around 100 older people and older peoples groups, with Edinburgh City Council A City for All Ages. 3 Oct 2012.

Raised awarenes of Centre work among policy makers in local Government and general public.
Year(s) Of Engagement Activity 2012
 
Description CCACE - Get Up and Go publication 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Get Up and Go 2012 - Article titled "Staying Sharp" in the magazine for the over 50s, published by the City of Edinburgh Council.

This is distributed to thousands of older people in the City of Edinburgh and surrounding area.
Year(s) Of Engagement Activity 2012
 
Description CCACE - Kickstart Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach Local
Primary Audience Schools
Results and Impact 20 pupils attended a workshop which introduced them to science and university life.

Greater awareness of possibility of going to University and studying ageing-related material among school pupils, especially from more deprived areas.
Year(s) Of Engagement Activity 2013
 
Description CCACE - London Science Museum 3D brain 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact 400 individuals visitied a stand and attended a talk on the CCACE 3D brain and associated brain imaging research. The event sparked much interest and questions across the day.
Year(s) Of Engagement Activity 2013
 
Description CCACE - MRC Centenary open day and debate 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Over 550 members of the public attended the CCACE open day and debate, which sparked questions and discussion afterwards.

Huge amount of discussion about and enthusiasm for research in to cognitive and other aspects of ageing across the whole human lifecourse. The public appreciated the highly professional nature of the brain maze. The public appreciated the highly professional debate, with nationally-known figures (Sally Magnusson, Tam Dalyell) taking part. In the reception after the debate we hosted about 200 people and launched our LBC Lifetimes, which is a web site which contains "mini-books" telling the lifestories of some of the Lothian Birth Cohort members and some of the scientists. The aim of this is to explain further the research in the Centre and to bring in a wider public.
Year(s) Of Engagement Activity 2013
URL http://youtu.be/_5naEFwmqYs?a
 
Description CCACE - Science and the Parliament 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Science and the Parliament 2011, 9 Nov 2011 - CCACE materials displayed. Attendance of several hundred, including School pupils.

Increased awareness among atendees of the Centre's work.
Year(s) Of Engagement Activity 2011
 
Description CCACE - Scottish Older People's Assembly 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Scottish Older People's Assembly 2011 and 2012 - Stand of CCACE and LLHW information and materials.

Several hundred delegates (3rd Sector, Policy, Government) showed much interest in Centre findings on cognitive ageing.
Year(s) Of Engagement Activity 2011,2012
 
Description CCACE - Still Life Dreaming 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Still Life Dreaming - a play about the Lothian Birth Cohort 1936 at the Edinburgh Festival Fringe reported by the BBC Arts correspondent Will Gompertz "The play reveals some of the results and explores the subject of cognitive aging. Which is interesting. But the human stories are better. The tales that emerged from the individuals who had taken the test back in 1947 are now re-told" . Over 700 people attended the play in its 5 day run.

http://bbc.in/r17M3f Also reported in the BBC Review Show and The Times.
Year(s) Of Engagement Activity 2011
URL http://bbc.in/r17M3f
 
Description CCACE - Training courses 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact In 2012, 2013 and 2014 CCACE ran a number of short taining courses. These included "introduction to R programming", "longitudinal modelling", and "systematic reviews and meta-analysis".

R programming course has run 7 times between 2012-2014 with over 200 attendees.

SR course - 2 sessions. Dec 2012 (n = 16), November 2013 (n = 18).

Longitudinal modelling - 1 session in November 2013 (n = 50).

We have increased the visibility of CCACE and the skills that we can offer to a wider academic audience.
Year(s) Of Engagement Activity 2012,2013,2014
URL http://www.ccace.ed.ac.uk/students-training/training
 
Description CCACE Press release: Genetic Associations for Human Intelligence 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact CCACE published a press release following the publication of a study in the journal Molecular Psychiatry, conducted by Centre members, on the first direct biological evidence for a genetic contribution to people's general cognitive abilities.

Articles appeared in alll the UK broadsheet papers and international press (for example, the Guardian, Washington Post, ABC News, India Times). This has generated considerable interest in the Centre and has led to members of the international scientific community contacting CCACE members, and potential for new research collaborations. The Centre also produced the following video about the research http://www.youtube.com/watch?v=Y2ZXccfgWXk.
Year(s) Of Engagement Activity 2011
URL http://www.youtube.com/watch?v=Y2ZXccfgWXk
 
Description CCACE YouTube channel ccacevideo 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Since 2011 CCACE has posted 29 videos about events, research and the Centre on its YouTube channel.

The CCACE video channel has 36 subscribers and its videos have been viewed 13,302 times (as of 7th November 2014).
Year(s) Of Engagement Activity 2011,2012,2013,2014
URL http://www.youtube.com/ccacevideo
 
Description CCACE celebrates Scottish research cohorts 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact Event held at Edinburgh's General Assembly Hall, June 2018. Hundreds of participants and researchers from Scottish cohort studies came together to celebrate their contribution to, and crucial role in, healthcare research. The day's programme covered research across the entire human lifespan, beginning with a presentation by Professor James Boardman on effects of premature birth, and ending with a talk from Professor David Batty on regional disparities in mortality. The event also offered a unique opportunity to survey the opinion of current Scottish cohort participants on future uses and sharing of their data.
Year(s) Of Engagement Activity 2018
URL https://www.youtube.com/watch?v=GJBbqOq4qa8
 
Description CCACE eNewsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The Centres' Knowledge Exhange Officer produces a quarterly CCACE Newsletter detailing news and updates of Centre acitivity.

The Summer 2014 newsletter was circulated to 447 recipients with 190 (43%) opening it and 83 (19%) clicking on several of its links. For the Winter 2013/14 newsletter these figures were 446, 209 (47%) and 89 (20%).

In November 2011 this is circulated to a distribution list of over 220. Statistics from the January 2011 edition showed that ~60% opened the newsletter, and ~40% clicked on several of its links.
Year(s) Of Engagement Activity 2010,2011,2012,2013,2014
 
Description CCACE on Facebook: CCACEedinburgh 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact CCACE launched its Facebook page in 2011 featuring photographs, video and news about CCACE

147 people have "liked" the page so far, and actively share CCACE's newsfeeds.
Year(s) Of Engagement Activity 2011,2012,2013,2014
URL https://www.facebook.com/CCACEEdinburgh
 
Description Calvin: 6-Day Sample CLS conference talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact C. Calvin: "Half a century older: A new follow-up wave of Scotland's 6-Day Sample", talk given as part of methdology session at the Centre for Longitudinal Studies conference, 'The value and use of cohort studies for social investigation and policy making' held on 20.11.12 in London, UK. http://www.cls.ioe.ac.uk/

Sparked good questions, comments and discussion from audience members and enabled networking with peers from other institutions. The conference was also attended by policymakers.
Year(s) Of Engagement Activity 2012
 
Description Careers workshop presentation - Riccardo Marioni 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Careers workshop presentation to around 50 postgraduate students taking the University of Edinburgh MSc in Operational Research (Nov 2018).
Year(s) Of Engagement Activity 2018
 
Description Centre for Educational Sociology Lecture - Lindsay Paterson 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Paterson, L. (2018), Scottish Education Policy: Why Surveys Matter, CES Briefing No. 66, June.
Year(s) Of Engagement Activity 2018
 
Description Changing Ageing Partnership - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact CCACE Director, Professor Ian Deary, was invited to give the keynote presenttion on "How intelligence affects life and vice versa" at the Changing Ageing Partnership meeting in Belfast, Northern Ireland.

This was an important and unusual gathering of scientists, policy makers, funders, and relevant charities concerned with ageing and physical and cognitive functioning. It was a good opportunuty to communicate the Centre's findings and aims. In doing this, it was possible to influence users and fellow scientists in one meeting.
Year(s) Of Engagement Activity 2009
 
Description Cox - Age UK - New Dynamics of Ageing 2013 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Age UK A New Dynamic of Ageing. Research from the Lothian Birth Cohort 1936 showcased at this lay-conference was amongst the 35 ageing research projects who shared their latest findings, evidence and insights on age-related issues through an interactive exhibition area, presentations and themed parallel sessions. I was one of 3 CCACE members to man the stall. The meeting was attended by c.500 delegates.

Exposure.
Year(s) Of Engagement Activity 2013
 
Description Cox - MRC Centenary Event - Brain Maze 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact MRC Centenary Event - Brain Maze activity demonstration. Contributed to demonstration design, set up and a small piece in the introductory film. This was part of a series of nationwide events designed to celebrate the MRC Centenary. The primary audience was the general public .

Exposure
Year(s) Of Engagement Activity 2013
 
Description Deary - 'Glasgow Skeptics' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact 10 Quite Interesting Things About IQ". Public Talk to 'Glasgow Skeptics' Prof Ian Deary. 20 Feb 2012. This was attended by about 100 people. The audience was very interested and inteactive in discussing findings about human intelligence and how it ages.

1,900 views of YouTube video
http://youtu.be/MGnCYdr7dYE
Year(s) Of Engagement Activity 2012
URL http://youtu.be/MGnCYdr7dYE
 
Description Deary - AQMeN social mobility 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact This was the opening/public lecture for a course on structural equation modelling aimed at people interested in social mobility.

Both the statistical methods and the practical findings with respect to social mobility were conveyed to a range of individuals from post-graduate students to senior researchers to members of the public.
Year(s) Of Engagement Activity 2012
 
Description Deary - Age and Brain keynote, Nottingham 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact About 50 people attended this inaugural meeting of ageing reseachers at Nottingham. This was the keynote talk and there was a good question session afterwards.

The broad range of ageing reseachers led to many 2-way suggestions for further biomarkers that could be studied with respect to cognitive ageing.
Year(s) Of Engagement Activity 2012
 
Description Deary - All-party Parliamentary Group 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact The lLothian Birth Cohort 1936 study was presented as a poster at this high-profile gathering of Parliamentarians and research charities.

Many interested members of the House of Lords and some MPs came to discuss the findings on cognitive ageing, and were very interested.
Year(s) Of Engagement Activity 2012
 
Description Deary - Biomarkers of cognitive ageing 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact This workshop was attended by about 60 people. Deary was presenting CCACE's recommendations on cognitive tests for cohort studies, following an extensive review in collaboration with CCACE staff.

The workshop was funded by the MRC. The outcomes were a very lively discussion, revised written guidelines, and a final report that will be poublished by the MRC.
Year(s) Of Engagement Activity 2012
 
Description Deary - Biomarkers workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact The work was commissioned by the Medical Reseach Council. The result was a long, detailed and comprehensive set of guidelines for measuring ageing phenotypes in older people. From CCACE, Deary and Nissan did all the work which contributed to the cognitive assessment recommendations for older age.

The work has been written as an MRC report. Publication in peer-reviewed journal and wider distribution to scientists will follow.
Year(s) Of Engagement Activity 2012
 
Description Deary - British Academy British Psychological Society lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact British Academy Lecture - Intelligent Scotland-Godfrey Thomson and the Scottish Mental Surveys. Prof Ian Deary. 17 Oct 2012. This was attended by over 150 indivdiuals. The event was a sell-out and there was a spill over room used. The lecture is available on the Academy website.

The talk led to a lively question session dfrom both historians and scientific researchers. The talk has been viewd many times online and is being written up for the British Academy journal as a separate article.
Year(s) Of Engagement Activity 2012
 
Description Deary - COEN 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact About 50 people attended this 1 hour talk followed by about 20 minutes of questions.

There was a broad range of individuals interesetd in brain ageing, which led to several 2-way suggestions for additional work, some of which has resulted in further communication and collaboration.
Year(s) Of Engagement Activity 2012
 
Description Deary - Cafe Scientific 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact About 50 people attended for this discussion of ten issue to do with human cognitive ability. For each topic, Deary spoke for 5 minutes and took 5 monutes of discussion. All discussions had to be curtailed because of intense interest.

There was a clear high interest in the topics and the audience contributed much discussion. The overall result was excellent and increased awareness of new findings and research problems in the area of human cognitive function across the lifecourse.
Year(s) Of Engagement Activity 2012
 
Description Deary - Cafe Scientific 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Ten "quite interesting things" about human intelligence. Prof Ian Deary. Café Scientifique, Edinburgh. 18 Oct 2012. This was attended by about 60 people, filling the space available. Deary presented each of the 10 issues in a 5 minute presentation followed by 5 minutes of discussion.

The audience was very lively and interested, and learned a great deal about the measurement, consequences, and ageing of human intelligence.
Year(s) Of Engagement Activity 2012
 
Description Deary - Centre for Neuroscience, Strathclyde University 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact This broad talk on the Centre's research was attende by over 40 people, and followed by a lively question session for about 20 minutes.

This was an opporunity to discuss cognitive ageing and cognitive epidemilogy findings with a broad range of neuroscientists, who were interested in the findings.
Year(s) Of Engagement Activity 2012
 
Description Deary - David Bartholomew talk on Godfrey Thomson 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact This was a talk in honour of David Bartholomew's research on statistics and intelligence. About 80 people attended.

There was a broad range of academics present, and the talk resultsed in an invitaiton for a further talk (at Winton Capital).
Year(s) Of Engagement Activity 2011
 
Description Deary - Edinburgh Alliance for Complex Trait Genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact About 125 people attended this first meeting of Edinburgh's researchers on complex trait genetics. There was a good discussion after the talk and there were many conversations that followed as a wide range of genetics researchers came up with suggestions for other possible approaches.

The suggestions for further collaboration and approaches are being fololwed up. A subsequent meeting of this group has been help and there is strong momentum for it to conrinue.This means that the human work on genetics of cognitive ageing is informed by a wide range of geneticists who have pervously not been in contact.
Year(s) Of Engagement Activity 2012
 
Description Deary - Edinburgh Friendship centre 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact About 120 older people attended this 1 hour lecture, followed by 30 minutes of discussion.

Attendees were interested to hear about the factors that affect cognitive ageing in older people.
Year(s) Of Engagement Activity 2011
 
Description Deary - Fulbright Scholars 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Talk entitled "How intelligence affects life and vice versa" given to visiting Fulbright Scholars.

This very able group of individuals were interested to hear about CCACE's research and the Lothian Birth Cohorts. They asked many questions.
Year(s) Of Engagement Activity 2012
 
Description Deary - Garfield Weston Foundation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Supporters
Results and Impact The Garfield Weston Trustees were making decissions about which research projects to support. They decided to contribute £250,000 to the Disconnected Mind project.

Awareness among the Trustees of the importance of human cognitive ageing and the illiciting of a large monetary award for the research.
Year(s) Of Engagement Activity 2013
 
Description Deary - Genes and environment in cognition, Liverpool BNA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact This was an invited talk followd by discussion attended by over 100 people.

This was part of a day aimed at examining environment-genetics interactions. The outcome was that it affected subsequent grant applications for Deary's cohorts.
Year(s) Of Engagement Activity 2012
 
Description Deary - Humanist Society Scotland 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Over 80 people attended a public lecture on the factors affecting social mobility. The talk lasted 1 hour and there was 1 hour of questions.

This important and topical issue was of great interest to the attendees, witnessed by the long discussion period.
Year(s) Of Engagement Activity 2012
 
Description Deary - LBC 1936 BBC Radio 4 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact This was a long and clear story on the high-audience PM programme on radio 4. It gave a clear account of the Lothian Birth Cohort cognitive ageing research.

This programme has a large national and international audience. Even from the number of contacts we had from people who heard it, the feedback was very positive concerning how they conveyed our reseach and it prompted much discussion about cognitive ageing which we assume took place throughout the country.
Year(s) Of Engagement Activity 2013
URL http://www.bbc.co.uk/news/health-22767016
 
Description Deary - LBC1936 media stories 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact International interest from high-profile publications concerning the results which showed that brain grey matter-cognition associaiotns in old age could be explained by IQ tests taken 60 years ealier.

Stories in international publications which we assume have been read and discussed by very large numbers of individuals.
Year(s) Of Engagement Activity 2013
URL http://www.sciencedaily.com/releases/2013/06/130604135416.htm http://healthland.time.com/2013/06/06/...
 
Description Deary - MRC Lifecourse Epidemiology Unit, Southampton 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Invited for a cross-Centre visit. This consisted of a 1-hour talk and a prolonged question session. Also, there were meetings with key scientists from the Unit.

This was a well-attended seminar and a lively question session. The meeting resulted in subsequent collaborations which have produced papers that originated in both Centres.
Year(s) Of Engagement Activity 2012
 
Description Deary - Marchmont St Giles Church Guild 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The audience were enthusiastic and asked many relevant questions about the cogntive ageing research.

Enthusiasm for and great awareness of the contributors to peoples differences in cognitive ageing and how these arise from across the full human lifecourse.
Year(s) Of Engagement Activity 2013
 
Description Deary - Nature - Genetic associations for human intelligence 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Press Release: Study Shows Genetic Associations for Human Intelligence. The first direct biological evidence for a genetic contribution to people's general cognitive abilities, reported in Molecular Psychiatry. Cconsiderable interest in the international press including the Guardian http://bit.ly/nXGcQT, Washington Post and New Deli Times.

Video: http://youtu.be/Y2ZXccfgWXk viewed 1,200 times in a year. Prof Ian Deary et al. Aug 2011.
Year(s) Of Engagement Activity 2012
 
Description Deary - Neuroscience Day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact This keynote talk was attended by about 300 neuroscience researchers, from undergraduate students to senior academics. There was a good question session after the talk.

This was an excellent opportunity to convey the genetic findings on cognitive ageing to the broadest range of neuroscience reseachers at Edinburgh, and led to further suggetions for possible candidate genes and genetic approaches to cognitive ageing which are being followed up.
Year(s) Of Engagement Activity 2012
 
Description Deary - Our Changing World lecture series 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact To a sell-out audience of about 200, Deary described the changing demographic structure of the world, Europe, the UK, and Scotland. He described the incresae in dementia and cognitive delincearound the world. He described the research group's contribution to cognitive ageing research.

There was a lively discussion session which showed substantial interest and wished to know more about human cognitive ageing and its impact on the individual and society. This has been viewed on YouTube over 1300 times.
Year(s) Of Engagement Activity 2012
URL http://www.youtube.com/watch?v=DkCFXdt7Fhc
 
Description Deary - Pilrig St Paul's Guild 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Around 30 older people attended the talk and there were many questions and discussions after about successful cognitive ageing and the lifestyle associaioted with this.

Wider recognition of the contributions to healthy cognitive ageing. Appreciation of the unique nature of the research in Edinburgh.
Year(s) Of Engagement Activity 2013
 
Description Deary - PsySTAR annual summer school 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact This talk was attended by about 100 people, comprising medical doctors planning to do a PhD in psychiatry, and other researchers like Deary who were prospective supervisors.

Several attendees got in touch after the talk to discuss possible PhDs at the Centre and with the Lothian Birth Cohorts.
Year(s) Of Engagement Activity 2012
 
Description Deary - Reverse causation and psychological tests 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact About 50 cohort researchers attended this day-long series of talks on research methods for cohorts.

Researchers discussed the issues raised and used them to implement changes in cohort studies.
Year(s) Of Engagement Activity 2011
 
Description Deary - Roslin seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Attended by about 75 people, this braod-based talk on the Lothian Birth Cohorts was followed by about 20 minutes of questions.

A very interested audience from a range of disciplines, several of whom were in touch to talk about possible genetics collaborations.
Year(s) Of Engagement Activity 2012
 
Description Deary - Royal Society of Arts 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Royal Society of Arts Event: Life is a Marathon. Presentation of the "latest scientific thinking about increasing human longevity in terms of trends, training and persistence". Video of talk online. This was a sell-out event, attended by about 125 people. It was a pre olympics event looking at human ageing, including cognition.

>6,000 views on YouTube http://www.thersa.org/events/video/vision-videos/panel-discussion10. The wide range of attendees -- from scientist to general public -- made this a very effective forum for discussing human lifecourse issues, including the Centre's findings on cognition.
Year(s) Of Engagement Activity 2012
URL http://www.thersa.org/events/video/vision-videos/panel-discussion10
 
Description Deary - Scotland in Miniature 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Media Coverage: The Six Day Sample, Scotland in Miniature. STV and Radio Scotland. Prof Ian Deary. Nov 2012.

Many prospective participants got in touch to agree to take part following the media stories.
Year(s) Of Engagement Activity 2012
 
Description Deary - Scottish Parliament Cross-Party Group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact The findings from the Birth Cohort Studies and the Centre for Cogntive Ageing and Cognitve Epidemiology are presented to this group and the implications for policy discussed. The group contains members of the Scottish Parliament, senior policy individuals from ageing-relevant charities, and a few academics.

This offers the Centre and its controbuting scientists a direct line to policy makers in Scotland with respect to issues affecting older people.
Year(s) Of Engagement Activity 2011,2012
 
Description Deary - Stewart Men's Club 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact To an audience of around 40 Deary described the cognitive ageing work using the Lothian Birth Cohorts. There were many quesiotns after the presentation.

There was obvious interest in and greater appreciation of the factors that contribute to peoples difference in cognitive and brain ageing.
Year(s) Of Engagement Activity 2013
 
Description Deary - Strictly Science exhibition 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Viewed to date by over 120 individuals, the video aims at novel ways to conduct human brain research in vivo.

The talk has now gained 120 video views on YouTube (http://youtu.be/hr91MTjuVFo).
Year(s) Of Engagement Activity 2013
 
Description Deary - The British Academy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The lecture was a sell out to about 200 people (including overflow). Deary addressed both organisation's audiences by talking about the history of his cognitive ageing work and also the most important findings have arisen from it.

From across the humanities and sciences divide it was clear that there was much interest in the Scottish Mental Surveys and their history and also the follow-up work on them that is contributing to our knowledge of cognitive ageing. There was a long quesiotn session afterwards and the lecture is online. It already has 265 views on YouTube.
Year(s) Of Engagement Activity 2012
URL http://www.britac.ac.uk/events/2012/An_Intelligent_Scotland.cfm
 
Description Deary - University of the Third Age 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact About 100 older people attended the talk to hear about the factors that affect cognitive ageing and wellbeing in old age. There was an extensive discussion session afterwards.

Information on cognitive ageing was conveyed to people for whom it was highly relevant.
Year(s) Of Engagement Activity 2012
 
Description Deary - Winton Capital Management 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact 'Professor Sir Godfrey Thomson and the Scottish Mental Surveys of 1932 and 1947.' Winton Capital. Oxford, UK, May. Prof Ian Deary. 11 May 2012. 60 employees.

This raised awareness among a group of highly quantitative workers in the finance industry about issues to do with cognitive ageing and the manipulation of datasets involved in the research.
Year(s) Of Engagement Activity 2012
 
Description Deary - World Congress on Active Ageing 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact This was an invited symnposium on the work of the Lothian Birth Cohorts. Our work was given a 2-hour period, and the attendance was at capacity for the room (about 150). There were 5 talks from our group.

The audience was an excellent combination of researchers, practitioners, and general public. There was great interest in the cohort findings on cognitive ageing. The session resulted in a subsequent collaborative grant application to LLHW for a study on activity and sedentary behaviour and cognitive ageing.
Year(s) Of Engagement Activity 2012
 
Description Deary: invited keynote speaker, Aqmen Resources for Democracy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Deary, I. J. The Scottish Mental Surveys of 1932 and 1947: still important after all these years. Resources for Democracy: Celebrating Scottish Social Surveys (ESRC Festival of Social Science Event 2012), 9th November 2012, Scottish Parliament. Organised by AqMeN http://aqmen.ac.uk/.

Informed peers, parliamentarians, policymakers and potential collaborators from other social surveys across Scotland about the Lothian Birth Cohort and 6-Day Sample studies. Audience members showed great interest in the studies and several productive conversations were had as a result.
Year(s) Of Engagement Activity 2012
 
Description Della sala and CCACE - Edinburgh Festival Fringe 2012 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Talking About 'Captain Ko and the Planet of Rice'. Discussion event about art, science and cognitive decline. 15 Aug 2012.

YouTube Video: http://youtu.be/UKhOD8KXaZY. The play was very well attended and a spin off discussion event was held at which people could meet the artists and scientsts and ddiscussed issues to do with cognitive ageing and how they were represented in the 3 pays that were the production.
Year(s) Of Engagement Activity 2012
 
Description Della sala and Gow - Make me a scientist schools talent show 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach Regional
Primary Audience Schools
Results and Impact Make me a Scientist Schools Science Talent Show. CCACE member Dr Alan Gow hosted the Schools talent show and Prof Sergio Dela Sala was a judge in this X-factor style Science talent show. http://www.makemeascientist.org/ Around 200 parents and pupils attended and the event was filmed. Dr Alan Gow and Prof Sergio Dela Salla. 12 Oct 2011.

This was hugely enjoyed by all involved, and it was a good opportunity for the Centre to take a high profile among school pupils who are interested in pursuing a scientific career.
Year(s) Of Engagement Activity 2011
 
Description Dementia Awareness day - John Starr/Karen Horsburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The aim was to raise awareness of dementia and to highlight current research activities on dementia within CCACE (Drs Horsburgh, Fowler and Prof. Starr, were speakers). The audience comprised mainly the public with a few academics.

Raised public awareness of dementia and the research that CCACE is doing on this.
Year(s) Of Engagement Activity 2010
 
Description Dementia Buddies Scheme - Szu-Han Wang 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Knowledge exchange between patients with dementia and researchers working on the biological aspects of dementia. Patients and carers visit us at our research labs and we speak to them about their lived experience. This has sparked much discussion with the patients.
Year(s) Of Engagement Activity 2018
 
Description Does language learning lead to healthier ageing? - Thomas Bak 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog for MEITS website
Year(s) Of Engagement Activity 2018
URL http://www.meits.org/blog/post/does-language-learning-lead-to-healthier-ageing
 
Description Drop-in activity at the Edinburgh International Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Staff and students from CCACE hosted a drop-in activity stand at the National Museum of Scotland, with the theme: 'How Old Are You Really?' The aim was to draw attention to the many ways - other than chronological age - that researchers of ageing try to measure how old someone is. In a sign of how well received the stand was, there were queues to enter everyday due to reaching maximum visitor capacity.
Year(s) Of Engagement Activity 2009,2018
 
Description Edinburgh City Council A City for All Ages Seminar - Ian Deary/Beverly Roberts 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact CCACE Director, Professor Ian Deary, presented at an ACFAA Seminar entitled "Healthy Mental Ageing" at Edinburgh City Chambers. A City for All Ages (ACFAA) is a joint initiative between the City of Edinburgh Council, NHS Lothian, and voluntary and commercial organisations. The event highlighted recent developments in CCACE research which aims to identify key factors that lead to cognitive decline and those associated with successful ageing. Photographs from the Transformations Life Portraits exhibition organised by CCACE in April also featured at the event.


The seminar gave participants from the public, voluntary and public sectors the opportunity ask questions about the studies and wider issues regarding healthy mental ageing. The event generated very positive feedback with over 30 participants signing up to receive further information from the Centre. As one of the participants summarised: "Events like this are a great way of connecting the university (scientists, social scientists & humanities scholars) with the council (and other public sector
Year(s) Of Engagement Activity 2010
 
Description Edinburgh International Science Festival - "'Ah kent yer faither': myth and fact in social mobility" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Centre Director Professor Deary delivered a talk entitled "'Ah kent yer faither': myth and fact in social mobility", during the Edinburgh International Science Festival in April 2011.

Exposure of our work to a broad and diverse public group.
Year(s) Of Engagement Activity 2011
 
Description Edinburgh International Science Festival - 'Measuring the Brain' 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The Centre's Deary-Liewald Rection time task and Interactive 3D brain were exhibited at "Measuring the Brain", part of the Edinburgh International Science Festival's Medical Detectives theme. The 3D brain is an interactive exhibit of the brain, allowing people to view and manoeuvre MRI scans of young and old brains in 3D. Several CCACE staff and members were there to speak to the visitors and demonstrate a variety of cognitive assessments and displays, including Mr Jack Nissan, Dr Robin Morton and Ms Natalie Royle.

The venue attracted around 3,000 visitors during 17th - 22nd April 2011. More than 300 members of the public visited the stand, participated in activities, asked questions, and took away information about how CCACE measures the brain both physically through brain imaging and through psychological/cognitive tests.
Year(s) Of Engagement Activity 2011
 
Description Edinburgh International Science Festival - Stay Sharp! 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact CCACE took part in Discover Science, 'Meet the Medics and Vets', a range of hands-on drop-in activities from the the University of Edinburgh, at the National Museum of Scotland. The Stay Sharp! exhibit looked at how our brains change as we get older and how CCACE scientists study this in the Lothian Birth Cohort. Children tried out some of the tests and even did some genotyping using no more than a clothes line and some clothes pegs.


An estimated 2,553 visited this element of the Discover Science Programme from 12 - 17 April. Exhibits proved popular with adults and children alike.
Year(s) Of Engagement Activity 2010
 
Description Edinburgh International Science Festival - Ten Things I Hate About Your Personality... and Mine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Ian Deary delivered a sell-out lecture to 200 attendees called "Ten things I hate about your personality... and mine". In it, he focussed on the five factor model of personality. He also talked about how differences in these traits originate and the effects they have on people's life-long health and wellbeing, including associations between personality and mortality.


200 Attendees at a keynote talk as part of the well publicised Big Ideas section of the Science Festival. After the talk Ian encouraged people to stay behind and a large number of people asked questions and discussed more about personality for almost an hour. Many of the audience had taken a CCACE on-line personality test before coming to the lecture.
Year(s) Of Engagement Activity 2010
 
Description Edinburgh Science Festival 2010 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Over the week over 600 people from the general public (mostly children) participated in psychometric assessments of handedness and cognitive speed as well as assessments of their grip strength and hand symmetry. This sparked questions and discussions about the meaning and relationships of these measures.

Exposure of our work to a broad and diverse public group, as well as many interested discussions.
Year(s) Of Engagement Activity 2010
 
Description Famelab, Glasgow Science Centre 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact At Famelab ("UK's biggest competition to find new voices of science communication") the CCACE's Interactive 3D Brain was demonstrated as part of a presentation in Glasgow Science Centre, on 19th November 2011.

Following this, Mr Jack Nissan, the CCACE's Human Testing Technician, was invited to demonstrate the 3D brain in a workshop for 26 primary school children in Edinburgh on 9th March 2011.
Year(s) Of Engagement Activity 2011
 
Description Festival of Science 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact CACCE is represented by three Meet the Expert hands on activities led by Dr Mario Parra (CCACE Associate Member), PhD student Joanna Brooks (representing Robert Logie) and Dr Dominika Dykiert (representing Ian Deary). The CCACE Scientists presented three activities over 2 days in September: The Colour of Memory; Why the right side of the brain prefers the left side of space and Reaction times: How to win at snap!

Allowed members of the public to interact one-to-one with experts in ageing research. Raising awareness of the Centre and contributing to a well publicised professional science communication event. Jim Jackson, former Chief Executive of Alzheimer's Scotland closed the workshop discussions by saying:
"[We need to] engage with the dynamics of ageing over time. At the same time recognising it is not ageing per se you are interested in... it is the individual differences, the things that people co
Year(s) Of Engagement Activity 2010
 
Description Guest speaker - Barclays 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Guest speaker at Barclays Wealth Breakfast meetings (Sept 2008; June 2009) to raise awareness of Disconnected mind programme. Audience all lay and potential donors.

Possible additional funding. Result awaited.
Year(s) Of Engagement Activity 2008,2009
 
Description Harris - DNA from peas 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach Local
Primary Audience Schools
Results and Impact ~50 children were involved in the workshop.

Increased interest in science among primary school pupils.
Year(s) Of Engagement Activity 2013
 
Description Healthy ageing - protecting your brain - Alan Gow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Presentation on factors related to brain health as part of the Spotlight on Science series at Exploration Day, Heriot-Watt University, Edinburgh, UK, 19th May 2018.
Year(s) Of Engagement Activity 2018
 
Description Healthy cognitive ageing: findings from the Lothian Birth Cohorts - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Presentation to the Medico-Chirurgical Society of Edinburgh. Ian Deary summarised the Lothian Birth Cohorts studies and their many contributions to healthy cognitive ageing. This was followed by half an hour of questions and debate.
Year(s) Of Engagement Activity 2018
 
Description Horizons in Ageing - I Deary / R Logie 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact CCACE co-hosted a series of evening talks titled "Horizons in Ageing" chaired by Prof Ian Deary and including CCACE research group leader Prof Robert Logie who spoke on 'Non-invasive and Specific Clinical Assessment of Alzheimer's Disease'

Around 60 non-specialists attended the talks and asked questions.
Year(s) Of Engagement Activity 2011
 
Description How to Age Well - Alan Gow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Presentation on factors related to brain health as part of the Edinburgh Wellbeing Festival, Edinburgh, UK, 27th January 2019
Year(s) Of Engagement Activity 2019
 
Description ISMRM British Chapter. 14th Annual Scientific Meeting and Workshop 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Poster by Valdes Hernandez MC, Ferguson KJ, Bastin ME, Wardlaw JM "An Automatic Tissue Segmentation Approach using Multispectral MRI Analysis for White Matter Lesions and Brain Volume Analysis"

Interest shown by participants about the method presented
Year(s) Of Engagement Activity 2008
 
Description ISMRM-ESMRMB Joint Annual Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Muñoz Maniega, S., Penke, L., Valdés Hernández, M. C., Murray, C., Royle, N. A., Gow, A. J., Clayden, J. D., Starr, J. M., Bastin, M. E., Deary, I. J., & Wardlaw, J. M. (2010). Multiparametric study of white matter integrity and cognition in old age. Talk given at the ISMRM-ESMRMB Joint Annual Meeting, Stockholm, Sweden, May 1-7, 2010.

Valdés Hernandez, M., Penke, L., Muñoz Maniega, S., Murray, C., Royle, N., Gow, A. J., Starr, J. M., Bastin, M. E., Deary, I.J., & Wardlaw, J. M. (2010). White matter lesion intensity and cognitive ability: relationships in youth and old age. Talk given at the ISMRM-ESMRMB Joint Annual Meeting, Stockholm, Schweden, May 1-7, 2010.

Engaged discussions with health professionals.
Year(s) Of Engagement Activity 2010
 
Description International Science Festivals - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact CCACE Director, Professor Ian Deary, was invited to give talks at the Edinburgh and Cheltenham International Science Festivals on "How Intelligence Affects Life and Vice Versa".

Both talks were sold out. This was an excellent opportunity to communicate findings concerning the Centres principal interests (cognitive ageing and cognitve epidemiology) to an interested lay public. Both lectures were followed by extended discussion sessions where the Festivals provided large break out spaces for a good few hours of interaction. CCACE Director, Professor Ian Deary, was interviewed by The Times newspaper on behalf of the work carried out by the Centre in his talk "How Intellig
Year(s) Of Engagement Activity 2009
 
Description Is learning languages good for your brain? - Thomas Bak 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Interactive invited talk about research on bilingualism and the brain at the "creative space", the Welcoming, Edinburgh. The session included drop-in activities in collaboration with Science Ceilidih and Leith Labs (in preparation for the Explorathon).
Year(s) Of Engagement Activity 2018
URL https://www.facebook.com/scienceceilidh/photos/a.1486421958282891/2187137418211338/?type=3
 
Description Joint Scottish Neurosciences Council/Neurological Alliance of Scotland event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Maria C Valdés Hernández presented the poster "Multimodality MR Imaging and Novel Image Processing Analysis Applied to the Ageing Brain: The Disconnected Mind Project" (authors: S Muñoz Maniega, NA Royle, MC Valdés Hernández, ME Bastin and JM Wardlaw) at the joint Scottish Neurosciences Council/ Neurological Alliance of Scotland event supported by the Scottish government "Putting our heads together - Clinical Neuroscience in Focus" 8th of September 2010. The event focused on strategies for improving the quality of care for Scottish patients.

Engaged discussions with health professionals.
Year(s) Of Engagement Activity 2010
 
Description Language learning and brain health - Thomas Bak 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Webinar presentation for the Open University (collaboration with Lingo flamingo tutor training programme).
Year(s) Of Engagement Activity 2018
 
Description Language learning as a cognitive intervention - Thomas Bak 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited talk at the "Languages and Cultural knowledge in global healthcare" organised by QUB-AHRC
Year(s) Of Engagement Activity 2018
URL https://pure.qub.ac.uk/portal/en/impacts/languages-and-cultural-knowledge-in-global-healthcare(b94c1...
 
Description Learning a foreign language as a cognitive intervention in dementia - Thomas Bak 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Talk presented at the World Federation of Neurology, Viana do Castelo, Portugal.
Year(s) Of Engagement Activity 2018
URL https://www.spneurologia.com/evento/wfn-aphasia-dementia-and-cognitive-disorders-bienn/332
 
Description Logie - As young as you feel 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A consultant for a new book for the general public 'As Young as You Feel' published by Reader's Digest in August 2012.

It is a book designed for those over 60 years on the realities of ageing.
Year(s) Of Engagement Activity 2012
 
Description Logie - CPD on working memory in elderly 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach Regional
Primary Audience Health professionals
Results and Impact Update and Continuing Professional Development lecture for geriatricians, geriatric nurses, general practitioners and medical students at the annual meeting of the Irish Geronotological Society in Cork, Ireland.
Audience of approximately 250. Intended reach was for the whole of the Irish Republic and for Northern Ireland.
Completed in September 2012
Title of the update lecture was "Working Memory in healthy ageing and Alzheimer's Disease'.
There was additional informal discussion with meeting participants.


Increased the knowledge of working memory in medical staff working in geriatric medicine.
Year(s) Of Engagement Activity 2012
 
Description Logie - Glasgow Science Centre 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Glasgow Science Centre 'Bodyworks' exhibition - Demonstrations arising from Professor Logie's research in CCACE are part of a major new exhibition 'Bodyworks' launched at the Glasgow Science Centre in 2012. Prof Robert Logie. 2012. Several hundred people attended.

This led to increased understanding of the memory processes that are affected by ageing among the general public.
Year(s) Of Engagement Activity 2012
 
Description Lyall - CCACE Stand 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Presented Centre for Cognitive Ageing and Cognitive Epidemiology stand at the World Conference on Active Ageing, August 2012

Attended by many at the conference, including general public, researchers, and policy makers and people from ageing charities.
Year(s) Of Engagement Activity 2012
 
Description Lyall - Edinburgh Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact MRC "Medical Detective" at Edinburgh Science Festival April 2012.

This was very well received by children and parents and raised awareness and discussion of how the mind works, including the effects of ageing.
Year(s) Of Engagement Activity 2012
 
Description MRC Network Newsletter - CCACE 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The CCACE was profiled in the MRC Network Newsletter.

Increased the profile of the Centre.
Year(s) Of Engagement Activity 2009
 
Description MRC Scotland Showcase - Ian Deary, Andrew McIntosh, Matthew Iveson 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact This was an event organised by the MRC to showcase their investments in health research in Scotland to Scottish Government officials. This involved manning a stand at the Scottish Parliament and talking about our research to guests. The primary audience was government officials and MSPs.
This took place on 06/02/2019

As well as describing our research we also discussed how our research could fit with current and upcoming government policy. We also handed out leaflets detailing 'policy asks'. The impact was primarily informing policy makers about current health research, but may have long-term impact as we follow-up connections made on the night.
Year(s) Of Engagement Activity 2019
 
Description MacLullich - 4AT screening instrument 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Health professionals
Results and Impact Dissemination of information on new 4AT screening instrument for delirium and cognitive impairment: multiple lectures to clinical audiences (2011-2012), incorporation into NHS Education for Scotland dementia education (2011), incorporation into Stirling Dementia Services Development Centre book on delirium (published June 2012).

Outcomes: Increased awareness of the 4AT. Increased hits to the 4AT website (www.the4AT.com): 816 visits between Sep 2011 and Sep 2012.
Impact: The 4AT is a new screening instrument for delirium and cognitive impairment which is being used in various NHS settings across the UK.
Year(s) Of Engagement Activity 2012
 
Description MacLullich - Delirium detection 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact Audio podcast on delirium detection for the BMJ Group (posted Nov 14 2011).

Unknown at this stage.
Year(s) Of Engagement Activity 2011
 
Description Media coverage of 6-Day sample (BBC) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Interview with Professor Deary and a research participant to publicise the 6-Day Sample study. This was then shown on BBC Reporting Scotland (3 times) and broadcast on Radio Scotland on several occasions on Wednesday 21st November 2012. Professor Deary was also interviewed live on John Beattie's lunchtime show, BBC Radio Scotland.

This informed the public and any potential research participants about the study. Several potential participants contacted Professor Deary after the coverage, asking to take part, and one participant living in England was subsequently recruited into the study.
Year(s) Of Engagement Activity 2012
 
Description Medical Research Council's Science Showcase in Scotland - Ian Deary 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Stall and presentation from Ian Deary at the Medical Research Council's Science Showcase in Scotland, Edinburgh, February 2019.
Year(s) Of Engagement Activity 2018,2019
 
Description Morton and CCACE - Brain Awareness Schools Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach Local
Primary Audience Schools
Results and Impact Brain Awareness Schools Workshop: CCACE Sponsored and contributed to the Edinburgh Neuroscience Brain Awareness Week workshop 'How we see the brain and what the brain sees'. 120, 11 year old pupils attended and engaged in hands on activities. Dr Robin Morton. 26 Mar 2012.

These workshops were very well received and the issues to do with brain activity and ageing were the focus of many interested questions from the school pupils.
Year(s) Of Engagement Activity 2012
 
Description Multilingualism, ageing and MCI - Thomas Bak 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited "international speaker" talk at the Universidad Autonoma de Baja California, Mexico.
Year(s) Of Engagement Activity 2018
 
Description NHS Scotland Joint meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Professors Deary and Starr attended a joint meeting on cognitive ageing between NHS Health Scotland and Centre for Cognitive Ageing and Cognitive Epidemiology's in Glasgow, UK, April 2011.

This was a good opportunity to influence those responsible for education and policy at the heart of the NHS in Scotland.

Positive feedback and information exchange.
Year(s) Of Engagement Activity 2011
 
Description National Forum on Ageing - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact CCACE Director, Professor Ian Deary, was invited to talk on cognitive ageing and cognitive epidemiology at the Scottish Government and General Register for Scotland: National Forum on Ageing, Enabling Independent Healthy Ageing.

This is a key Scottish gathering of practitioners and policy makers in the field of ageing and health. This was an excellent opportinuty to communicate the Centre's aims, work and the outputs of some of its major projects.
Year(s) Of Engagement Activity 2009
 
Description Neuropsychological evaluation & cognitive ageing - Thomas Bak 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Invited "international speaker" talk at the Universidad Autonoma de Baja California, Mexico.
Year(s) Of Engagement Activity 2018
 
Description New Scientist article - David Hill 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact New Scientist piece on DNA and intelligence
Year(s) Of Engagement Activity 2018
URL https://www.newscientist.com/article/2163484-found-more-than-500-genes-that-are-linked-to-intelligen...
 
Description Press release - David Hill 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Press release sent widely to coincide with a publication in Molecular Psychiatry. This was picked up very widely in tabloid, broadsheet, online and international press.
Year(s) Of Engagement Activity 2018
URL https://www.ed.ac.uk/news/2018/hundreds-of-genes-linked-to-intelligence-in-global
 
Description Press release - genes linked to dementia - Riccardo Marioni 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Press release of publications finding received widespread press coverage. Carried out a live interview with BBC Radio to discuss my study that identified 3 new genes associated with Alzheimer's disease (May 2018).
Year(s) Of Engagement Activity 2018
 
Description Public Interest and Health Workshop 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Poster presented by Valdes Hernandez MC, Bastin ME, Wardlaw JM "Automatic Brain Tissue Segmentation using Multispectral MRI Analysis of White Matter Lesions in the Ageing Brain"

Interest shown by the participants
Year(s) Of Engagement Activity 2008
 
Description Public panel engagement (mental health across the life course) - Matthew Iveson 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Study participants or study members
Results and Impact This involved presentations made to two public panels; the Administrative Data Research Centre Scotland Public Panel and the Mental Health Data Science Scotland Stakeholder Advisory Group.
The primary audience was the general public. There were roughly 8 people in attendance at each event, though the slides and summary have also been disseminated across the panel members who couldn't attend. The intended reach was local.

Dates: 12/10/2018 and 06/02/2019

The activity was aimed at presenting a planned study for linking mental health data for the Scottish Mental Survey 1947 cohort of individuals, and gauging public opinion on this study. We also wanted to invite feedback on the study design and its planned engagement work.

The output was evidence of support for our research which can be used in research governance applications. Feedback has also helped us design a public engagement strategy, including working with suggested third sector organisations to impact policy.
Year(s) Of Engagement Activity 2018
 
Description Public talks - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Centre Director Professor Ian Deary gave a number of talks to members of the public in 2010-11:

Oct 2010: Blackhall St Columba's Church of Scotland, Edinburgh. "Healthy mental ageing".
Feb 2011: Age UK Seminar, London. "The Disconnected Mind".
May 2011: Wellcome Trust Clinical Research Open Day. "Smooth as silk: 12 years of the Lothian Birth Cohorts", attended by an audience of 50.
June 2011: Skeptron: Glasgow Skeptics Annual Conference. "How intelligence affects life and vice versa", at Skeptron
Sept 2011: East Lothian University of the Third Age. "Healthy mental ageing in the Lothian Birth Cohorts od 1921 and 1936".
Oct 2011: Humanist Society Scotland. "Understanding social mobility".
Nov 2011: Edinburgh Friendship Centre. "How intelligence affects life and vice versa".

Greater awareness and knowledge among members of the public of all ages about scientific discoveries related to ageing, including the work of CCACE members.
Year(s) Of Engagement Activity 2011
 
Description Roberts - PhD Autumn Training School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact In 2012, 2013 and 2014 the CCACE Scientific Administrator collaborated with Edinburgh Neuroscience to run an extremely successful PhD training school. The day long workshop was set up to introduce current PhD students to topics such as "writing up your research", "where to get funding after your PhD", "how to give a good presentation". Across the two years the workshop has been attended by around 100 PhD students. Several senior staff in CCACE and beyond took part, including a talk and panel discussion from the CCACE Director.

PhD students are now more confident in their research skills and have a better understanding of the options available to them once they have completed their studies. This includes new skills in grant application and fellowship application.
Year(s) Of Engagement Activity 2012,2013,2014
URL http://www.edinburghneuroscience.ed.ac.uk/autumnschool/2013/index.html
 
Description Royal Society of Edinburgh - CCACE (John Starr) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact CCACE co-Director, Professor John Starr, was invited to talk at the Royal Society of Edinburgh as part of the "Drugs of the Future" meeting on the "Health of the elderly in Scotland".

None.
Year(s) Of Engagement Activity 2009
 
Description Royal Society of Edinburgh talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact 17 April 2009 Royal Society of Edinburgh talk as part of 'Drugs of the Future' meeting on the 'Health of the Elderly in Scotland'. Audience of mixed lay & professional.

N/A
Year(s) Of Engagement Activity 2009
 
Description Russ - Geographical variation in dementia 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Significant media coverage for a paper published in the International Journal of Epidemiology entitled "Systematic review and meta-analysis on geographical variation in dementia". Article published July 2012; media coverage September 2012.

Media interest.
Year(s) Of Engagement Activity 2012
 
Description Russ - psychological distress and mortality 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Significant media response to a BMJ article on psychological distress and mortality published in August 2012.

High profile media coverage.
Year(s) Of Engagement Activity 2012
 
Description School work placements - Robin Morton, Lorna Lopez 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact A number of CCACE members have been involved in three in-house school work placements for S5 and S6 students. This was co-ordinated by CCACE Knewledge Exchange Officer, Dr Robin Morton who built on earlier placements developed by CCACE Associate Researcher Dr Lorna Lopez to offer one day or week long placements based on the biology of ageing. The placements were aimed at students who were interested in a career in science but had no experience of research. The CCACEs work placements are on the University's formal list of placements offered to Edinburgh schools. During summer 2011 there were three student placements at the Centre. During their four-visits activities included shadowing scientists and PhD students, visiting the brain scanning unit, brain scan analysis, genetics, molecular biology during 4 day visits.

This activity has had a positive impact in bringing the excitment of cognitive ageing and cognitve epidemiology research to school pupils who are at a crucial stage in making decisions about a career in science. One 2011 student rated her work experience as 'Excellent' and said that the placement "definitely helped me to think more accurately about what I would like to study at University and I learned a lot about what aspects of science I like best". She also expressed her "admiration for the
Year(s) Of Engagement Activity 2007,2009,2010,2011
 
Description Science Festival participation - Riccardo Marioni 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Participation and stall design for Edinburgh Science Festival (Apr 2018). Many people (20+) learned about DNA methylation for the first time at this event.
Year(s) Of Engagement Activity 2018
 
Description Science Museum Who am I? Exhibit 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A new permanent exhibit in the Science Museum in London Who am I? Gallery. Featuring a picture of a LBC1936 participant , her brain scan and some of the mental tests carried out as part of the study.


Since 2001 the Science Museum has an average of 2.5 million visitors each year; 36% of visitors are 16 or under. This is a part of the new exhibition will have the potential to be seen by many thousands of visitors.
Year(s) Of Engagement Activity 2010
 
Description Scottish Education Policy Lecture - Lindsay Paterson 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Paterson, L. (2018), 'Scottish Education Policy: Why Statistics Matter', lecture in honour of Professor David Raffe, Edinburgh University, 26 March

Audience: mainly local academic audience, but also some researchers in Scottish Government.

Impact: Informal feedback suggested that it helped persuade some government researchers that survey research in education is valuable. This was picked up by the Royal Society of Edinburgh in their submission to the inquiry by the Scottish Parliament Education and Skills Committee into national assessments in schools. At the public evidence session at which Keir Bloomer (from the RSE) and Prof Paterson spoke, they stressed the importance of education surveys, and Prof Paterson's comments referred back to the SCRE surveys of 1932 and 1947 (upon which the LBC is based). The report of the Committee will appear this Spring.

The parliamentary evidence session at which this was discussed was on 23 January 2019.
Year(s) Of Engagement Activity 2018
URL https://media.ed.ac.uk/media/Professor+Lindsay+Paterson+%7C+Scottish+Education+Policy+A+why+statisti...
 
Description Scottish Informatics Computer Sciences Alliance DEMOfest 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Maria C Valdés Hernández exhibited "MCMxxxVI: a new versatile automatic technique for measuring volume biomarkers in the ageing brain" at Scottish Informatics Computer Sciences Alliance DEMOfest at School of Informatics 24th of November 2009. The participants were: representatives of universities across the Scottish Informatics and Computer Science Alliance, Scotland IS members and other leaders from Scotland's innovative, high tech and high growth businesses looking for consultants, KTP partners, technology ready for commercialisation and license, research partners and academics interested in working with business in other ways.

Engaged discussions and interest in the MCMxxxVI software.
Year(s) Of Engagement Activity 2009
 
Description Stall design for Edinburgh Science Festival - Riccardo Marioni 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Riccardo Marioni designed and helped run a stall on DNA methylation for Edinburgh Science Festival (Apr 2018).
Year(s) Of Engagement Activity 2018
 
Description Staying Sharp - Alan Gow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Presentation on factors related to brain health as part of "Ageing: From cells to Cognition" at the Pint of Science Festival, Edinburgh, UK, 14th May 2018.
Year(s) Of Engagement Activity 2018
 
Description Staying Sharp - Alan Gow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Presentation on factors related to brain health as part of Doors Open Day, the Royal Society of Edinburgh, Edinburgh, UK, 29th September 2018
Year(s) Of Engagement Activity 2018
 
Description Staying sharp in later life; your expert guide to ageing well 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact 'Staying sharp in later life' is a plain-language guide developed by Age UK in collaboration with researchers at CCACE . It provides accessible summaries of the latest research on a range of subjects from exercise and brain training, to diet, smoking and alcohol. There is a print and online version of the guide.
Year(s) Of Engagement Activity 2015,2018
URL https://www.ageuk.org.uk/information-advice/health-wellbeing/mind-body/staying-sharp/
 
Description Still Life Dreaming, Edinburgh Fringe Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Still Life Dreaming is a play about the Lothian Birth Cohort 1936 which ran for 5 days at this year's Edinburgh Festival Fringe. The play was produced by the Wellcome Trust to mark the 75th anniversary of their establishment in 1936, a birthday shared with the Lothian Birth Cohort of 1936. Spare Tyre theatre, using four actors with an average age of 75, worked with writer Pete Lawson to produce a thoughtful and entertaining take on the story of the LBC1936, emphasising some of the key aspects of the science as well as the history of the study. During writing and development stages of the performance the writer and director met with CCACE members to discuss the background to the study, and the current state of cognitive ageing research.

As a result, the play, rated '4 star', was seen by over 700 people and the LBC1936 and cognitive ageing were profiled in The Times and BBC2's Friday Night Review Show.
Year(s) Of Engagement Activity 2011
 
Description Talk at Edinburgh College - Michelle Luciano 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Talk at Edinburgh College (mostly high school students studying Psychology Highers) on the Genetics of Happiness.
Year(s) Of Engagement Activity 2018
 
Description Talk at Edinburgh College on the Genetics of Happiness - Michelle Luciano 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Talk to students, mainly high school pupils studying Psychology. The feedback from the talk was that it broadened the students' understanding of what Psychology involves as the talk emphasised biological determinants of behaviour. It sparked a change in attitudes to what Psychology entailed as a discipline. One student noted that she is now considering studying Psychology at University.
Year(s) Of Engagement Activity 2018
 
Description Talk at cohort event - Riccardo Marioni 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact Participation at research communication/reunion event for >400 cohort members of Generation Scotland and the Lothian Birth Cohorts (June 2018)
Year(s) Of Engagement Activity 2018
 
Description Talk to high school students - Riccardo Marioni 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact • Alzheimer's research communication to two final-year high school students preparing projects on genetics (June and Oct 2018).
Year(s) Of Engagement Activity 2018
 
Description Talks to policy makers and lay public - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Given a number of talks to policy makers and lay public on ageing. These include:

Deary, I. J. (2010). Health mental ageing. Tuesday Topics at Blackhall St Columba's Church of Scotland. Edinburgh, UK, October.
Deary, I. J. (2010). Healthy mental ageing and The Disconnected Mind. A City for All Ages Seminar. Edinburgh, UK, June.
Deary, I. J. (2010). NHS Health Scotland and Centre for Cognitive Ageing and Cognitive Epidemiology's Joint meeting on cognitive epidemiology: Intelligence and death, and causal hypotheses and public health implications. Glasgow, UK, April.
Deary, I. J. (2010). Ten thing I hate about your personality and mine. Edinburgh International Science Festival. Edinburgh, UK, April.
Deary, I. J. (2010). Why some minds age faster than others. The Second Scottish Caring and Dementia Congress (Plenary Lecture). Edinburgh, UK, March.
Deary, I. J. (2010). The Lothian Birth Cohort 1936. Craigleith Ladies' Probus Club. Edinburgh, UK, March.
Deary, I. J. (2010). How intelligence affects life and vice versa. University of Edinburgh Retired Staff Association. Edinburgh, UK, February.
Deary, I. J. (2009). The Lothian Birth Cohort 1936. Portobello Probus Group. Edinburgh, UK, November.
Deary, I. J. (2009). The day in 1947 when Scotland measured the whole nation's intelligence and why it still matters. Comiston Probus Group. Edinburgh, UK, November.
Deary, I. J. (2009). Cognitive ageing and cognitive epidemiology. The Scottish Government and General Register for Scotland: National Forum on Ageing, Enabling Independent Healthy Ageing. Edinburgh, UK, November.
Deary, I. J. (2009). How intelligence affects life and vice versa. Keynote talk at Changing Ageing Partnership. Belfast, Northern Ireland, September.
Deary, I. J. (2009). How intelligence affects life and vice versa. Keynote talk at University of the Third Age National UK Conference. Edinburgh, UK, September.
Deary, I. J. (2009). A lifetime of intelligence. Cheltenham International Science Festival. Cheltenham, UK, June.
Deary, I. J. (2009). How intelligence affects life and vice versa. Edinburgh International Science Festival. Edinburgh, UK, April.
Deary, I. J. (2009). The Lothian Birth Cohort 1936 study. Craigleith Probus Group. Edinburgh, UK, March.
Deary, I. J. (2009). How IQ affects life and vice versa. University of the Third Age. Edinburgh, UK, February.


Increased awarenes of CCACE and the science it produces.
Year(s) Of Engagement Activity 2009,2010
 
Description Ten (quite) interesting things about intelligence - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Presentation about intelligence differences to the University of the Third Age Science Group.
Year(s) Of Engagement Activity 2018
 
Description The Disconnected Mind: An Update. Age UK Headquarters - Simon Cox 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact Simon Cox met with the Research Team at Age UK to update them on new findings and discuss areas of mutual interest in ongoing and future plans for the study.
Year(s) Of Engagement Activity 2018
 
Description The Disconnected Mind: Technical Workshop. Reinsurance Group of America - Simon Cox 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact A technical workshop for the analysts at the UK offices of the Reinsurance Group of America; of particular interest was the work on polygenic risk scores and their ability to predict important outcomes of interest (including mortality) with increasing accuracy as sample sizes increase.
Year(s) Of Engagement Activity 2018
 
Description The Scottish Mental Surveys and the Lothian Birth Cohorts - Judy Okely 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Presentation on factors related to healthy cognitive ageing to around 15 members of the Edinburgh Electrical Engineering Society, October 2018.
Year(s) Of Engagement Activity 2017,2018
 
Description The Scottish Parliament's Cross Party Group on Older people and Ageing 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Centre Director Professor Deary delivered a talk entitled "The ups and downs of cognitive ageing in the Lothian Birth Cohorts of 1921 and 1936", to The Scottish Parliament's Cross Party Group on Older people and Ageing in Edinburgh UK, in September 2011.

The talk was attended by an audience of 20 comprising, several MSPs, civil servants, 3rd sector representatives, and members of the public. This is a valuable regular opportunity to feed through our scientific results to members of the Scottish government responsible for the ageing agenda and also the key ageing charities in Scotland.
Year(s) Of Engagement Activity 2011
 
Description Third Age Trust - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact CCACE Director, Professor Ian Deary, was invited to give a keynote talk on the work of the CCACE at the University of the Third Age 2009 National UK conference.

This meeting attracted several hundred older people who were keen recipents and discussants of information concerning the determination of cognitive ageing, and the phenomenon of cognitive epidemiology. A story and photograph from the talk were included in the U3A newsletter that goes to their many thousands of members.
Year(s) Of Engagement Activity 2009
 
Description Transformations: LIFE PORTRAITS - Ian Deary/Robin Morton 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact CCACE presented an exhibition of new artwork by the artist Linda Koscieicz-Fleming. In addition, CCACE held a workshop, using the artwork as a starting point for discussion. The theme was ageing, its meaning, importance and how CCACE could contribute to science and society through research on the ageing body and ageing mind. The workshop attendees included researchers, interest groups, artists and members of LBC1936. The exhibition proved itself to be an effective way of engaging the public and other interest groups in ageing, of challenging negative stereotypes and of celebrating the participants' indispensable contributions.


The exhibition was reported in a half page article in The Times. The project has a dedicated website and well represented on www.ed.ac.uk, including a 5 min "making of" video which will appear on the University of Edinburgh YouTube site. The artwork has been displayed at Edinburgh City Chambers. In addition, through this collaboration the resulting artwork was displayed as part of the "Coming of Age" exhibition from Jan - Mar 2011 in Newcastle.
Year(s) Of Engagement Activity 2010,2011
 
Description Twitter - CCACE 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Twitter.com/ccace has 460 followers and the account has tweeted 562 times.
Year(s) Of Engagement Activity 2010,2011,2012,2013,2014
URL http://www.twitter.com/ccace
 
Description UK Age Research Forum - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact CCACE Director, Professor Ian Deary, was invited to give a talk entitled "Cognitive ability affects life and vice versa" at the UK Age Research Forum Showcase Day: Shaping the Future in London.

This very well attended event attracted key ageing scientsts, funders, policy makers and charities from the whole of the UK. Ian Deary gave a talk on the Centre's aims, structure and scientific and knoweldge exchange activities. It led to further, similar invitations and to very good UK-wide awareness of the Centre.
Year(s) Of Engagement Activity 2008
 
Description UK Clinical Research Facilities 4th Annual Conference 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Parallel Session of the event. Speakers: Prof. Joanna M. Wardlaw and Dr. Alan J. Gow Participants: Delegates of the Conference

Useful communication of research methods to a wide range of coal-face collectors of data in clinical research facilities.
Year(s) Of Engagement Activity 2008
 
Description Understading the causes, consequences, and facets of neuroticism - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Presentation 'Understanding the causes, consequences, and facets of neuroticism' at the Wellcome STRADL Scientific Advisory Board meeting. Edinburgh, UK, October, 2018.
Year(s) Of Engagement Activity 2018
URL https://www.eventbrite.co.uk/e/wellcome-trust-stradl-award-annual-scientific-meeting-tickets-5059148...
 
Description Wardlaw - Invited Talk - Acute Stroke Imaging Event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact "Interpretation of the hyper-acute CT in stroke and how the imaging steps fit together in different locations" Better imaging and better outcomes for stroke patients: Acute Stroke Imaging Event, 17th May 2012, University of Stirling, Stirling.

NA
Year(s) Of Engagement Activity 2012
 
Description Wardlaw - Invited Talk - BrainStorm: The Interactive Neuro-Interventional Course 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Health professionals
Results and Impact "State of the ART 2: Ischaemic Stroke" BrainStorm: The Interactive Neuro-Interventional Course, 19th June 2012, Edinburgh.

NA
Year(s) Of Engagement Activity 2012
 
Description Wardlaw - Invited Talk - Clinical Grand Round 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Health professionals
Results and Impact "Small vessels in the brain cause big problems for society" Clinical Grand Round, 25th January 2012, Edinburgh Royal Infirmary, Edinburgh.

NA
Year(s) Of Engagement Activity 2012
 
Description Wardlaw - Invited Talk - European Confederation of Neuropathological Societie 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact "Neuroimaging of white matter disease" European Confederation of Neuropathological Societies CME Course "Leukoencephalopathies", 4th June 2012, Edinburgh


NA
Year(s) Of Engagement Activity 2012
 
Description Wardlaw - Invited Talk - Neuroscience Day 2012 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact "One small vessel in the brain, one giant problem for Society?" Neuroscience Day 2012, 1st March 2012, Edinburgh.

NA
Year(s) Of Engagement Activity 2012
 
Description Wardlaw - Invited Talk - The Society of Radiologists in Training Annual Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Health professionals
Results and Impact "New insights into the brain and vascular disease from imaging: why it's not just enough to be a radiologist" The Society of Radiologists in Training Annual Meeting, May 10th 2012, Edinburgh.

NA
Year(s) Of Engagement Activity 2012
 
Description Wardlaw - Invited Talk - UK Stroke Forum 2011 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Health professionals
Results and Impact "Neuroradiological aspects of cerebral small vessel disease"

NA
Year(s) Of Engagement Activity 2011
 
Description Wardlaw - Physical activity and brain size 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Radio Scotland interview regarding Neurology paper on physical activity and brain size in October 2012.

Media interest.
Year(s) Of Engagement Activity 2012
 
Description Wardlaw: Invited Talk - British Society of Neuroradiologists 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Health professionals
Results and Impact "Imaging in ageing. Common features, how do we interpret them and what do they mean?"

NA
Year(s) Of Engagement Activity 2011
 
Description Wellcome Trust Clinical Research Facility Open Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The Centre's Deary-Liewald Reaction time task and Interactive 3D brain were showcased at the Wellcome Trust Clinical Research Facility Open Day on 20th May 2011, with members of the public encouraged to try out the exhibits for themselves.

The open day attracted around 100 people.
Year(s) Of Engagement Activity 2011
 
Description What Keeps Us Sharp - Michelle Luciano 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Third sector organisations
Results and Impact Presentation on Mediterranean diet and cognitive health at the Age Scotland and Lothians Meeting of Older People's Groups and Organisations, Edinburgh, UK 6th November 2018.
Year(s) Of Engagement Activity 2018
 
Description What Keeps Us Sharp? - Alan Gow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Third sector organisations
Results and Impact Presentation on factors related to brain health at the Age Scotland Edinburgh and Lothians Meeting of Older People's Groups and Organisations, Edinburgh, UK, 6th November 2018
Year(s) Of Engagement Activity 2018
 
Description What Keeps You Sharp? - Alan Gow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Presentation on factors related to brain health as part of Brainworks Day (part of the Engaging Libraries project, funded by the Carnegie Trust and the Wellcome Trust), Kirkintilloch, UK, 28th April 2018.
Year(s) Of Engagement Activity 2018
 
Description What Keeps You Sharp? - Alan Gow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Presentation on factors related to brain health as part of Brainworks Day (part of the Engaging Libraries project, funded by the Carnegie Trust and the Wellcome Trust), Milngavie, UK, 27th July 2018.
Year(s) Of Engagement Activity 2018
 
Description What Keeps You Sharp? - Alan Gow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Show about factors related to brain health at the Edinburgh Festival Fringe as part of Edinburgh Beltane's Cabaret of Dangerous Ideas, Edinburgh, UK, 7th & 16th August 2018.
Year(s) Of Engagement Activity 2018
 
Description What Keeps You Sharp? - Alan Gow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Show on factors related to brain health at Go Live! At the Green as part of the Festival 2018, Glasgow European Championships, Glasgow, UK, 9th August 2018.
Year(s) Of Engagement Activity 2018
 
Description getBALANCED school workshops - Robin Morton, John Starr, Wendy Johnson, Lorna Lopez, Natalie Royle 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact CCACE in collaboration with Edinburgh Neuroscience ran a series of 21 workshops in 6 schools across Lothian, reaching over 350 secondary 3/4 pupils. The workshop, called getBALLANCED is based on the theme of balance in the brain and body structures were led by CCACE Co-director Professor John Starr and CCACE knowledge exchange officer Dr Robin Morton and developed by CCACE researchers.

"These workshops have made excellent progress in creating and developing awardness of brain function in school children, and communicating its importance for general health. Schools for learning disabled children as well as main stream schools were included. This encouraging of awareness of cognition, including ageing, at such an early age was found to be strongly welcomed by the children and teachers. Ken McDonald, Principal Biology Teacher, St Augustine's High
School commented
"My class spent
Year(s) Of Engagement Activity 2009,2010
 
Description getBALANCED workshop as part of the getBRAINY program 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Natalie A. Royle has been involved in the getBRAINY program for schools through the workshop 'getBALANCED' run by the Edinburgh Neuroscience and the Centre for Cognitive Ageing and Cognitive Epidemiology. The workshop was intended for secondary school students but was also administered in a Special school. The workshop, which ran from November 2009 to February 2010, aimed to inform students that aspects of their bodies can tell us a lot about a whole range of processes, including brain processes, which relate to cognitive ageing.

Pupils showed outstanding interest and asked many questions that led to deep discussions.
Year(s) Of Engagement Activity 2009,2010
 
Description www.ccace.ed.ac.uk 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The CCACE website (www.ccace.ed.ac.uk) was re-launched in January 2011, with separate sections for different stakeholder audiences and an accessible new media-led front page.

The website has had many thousands of visitors and is appreciated as a vibrant and regularly-updated window for the activities of the Centre.
Year(s) Of Engagement Activity 2010,2011,2012,2013,2014
URL http://www.ccace.ed.ac.uk
 
Description •Careers workshop presentation - Riccardo Marioni 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact • Careers workshop presentation to ~50 postgraduate students taking the UoE MSc in Operational Research (Nov 2018)

Some students were more interested in pursuing a PhD after this talk
Year(s) Of Engagement Activity 2018