Application for Centre for Regenerative Medicine

Lead Research Organisation: University of Edinburgh
Department Name: Royal (Dick) School of Veterinary Scienc

Abstract

A revolutionary new medical Centre, the Scottish Centre for Regenerative Medicine, has been opened at the University of Edinburgh. The Centre aims to develop new treatments for disease through research into stem cells.
?Stem cells? are master cells that have the ability either to multiply themselves or form the specialised cells that make up different tissues. Scientists and doctors believe that understanding how stem cells behave will lead to development of new treatments. The new treatments may involve replacing cells in the patient that have been damaged by disease. In other cases it may be possible to identify drugs that are able to make the patient?s own cells carry out the repair.
Stem cells will also be used in testing new drugs. At present the effect of new drugs is measured in tests with animals or with cells from animals. Sometimes the results are misleading because of differences between humans and animals. By using human cells for tests, scientists will reduce the number of animals that are used and the frequency with which misleading results cause expensive delays.
Scientists at SCRM have identified a number of diseases which to work on first. These are chosen because Edinburgh scientists lead the field in studying these diseases and stem cells may genuinely help to treat them. One aim is to be able to repair bone more effectively, especially to assist in hip repair. Other research will try to develop treatments to repair the nervous system, in diseases such as Multiple Sclerosis or Motor Neuron Disease. At present many patients with liver disease die before a suitable organ becomes available for transplantation. Stem cells may provide an alternative means of treatment. Stem cells may be used to repair the immune system and give back the patient?s ability to fight infections. In the longer term other programmes will address issues concerned with cancer, diabetes, heart disease and damage to the eye.
SCRM will provide high class training for the basic scientists and the doctors needed for the new treatments to be applied safely and effectively. Finally, SCRM will work hard to ensure commercialisation of its research and work closely with biotechnology and pharmaceutical companies.
Together these activities in the new Centre will help to position the UK at the forefront of international stem cell science, provide important new opportunities for development of novel therapies and create well paid jobs in the UK.

Technical Summary

Research with stem cells offers important opportunities for the development of new treatments for human disease. These treatments may involve replacement of cells that are lost or damaged, either by transplantation of stem cells into patients or administration of new drugs to stimulate the patients own tissues to repair the damage. Alternatively drugs may be administered to prevent the damage from occurring. Stem cell research is also expected to lead to improved and accelerated drug screening and reduce the number of animals that are sued for this purpose.

To address this immense opportunity, the Scottish Centre for Regenerative Medicine (SCRM) is being created at the University of Edinburgh by bringing together the world leading research groups presently in the Institute for Stem Cell Research in the School of Biological Science with those in the Medical School who have clinical interests in stem cell research and therapy. Uniquely in the UK, SCRM will cover the full spectrum of research that is required to move stem cell research from the bench to the bedside. Research will range from studies of the basic mechanisms that maintain stem cell populations both in people and in the laboratory, through projects to establish reliable procedures for the production of cells suitable for their clinical purpose to clinical trials with stem cells, their derivatives or new drugs.

In the first place, the new knowledge arising from research at SCRM will be applied in developing treatments for repair of the nervous system, liver, bone and cartilage or reconstruction of the immune system and blood systems. These are chosen because of Edinburgh?s research strengths in these areas and their suitability for these treatments. In the longer term other programmes will address issues concerned with cancer, diabetes, heart disease and damage to the eye. To support these programmes, SCRM will develop technologies required to advance this research, including modification of procedures established in the laboratory to make them suitable for large scale clinical use. SCRM will also have an active programme to ensure commercialisation of its research and develop collaborative research programmes with biotechnology and pharmaceutical companies. To support the critically needed expansion of this field SCRM will provide training for basic scientists and clinicians at all career levels.

Together the activities in the new Centre will help to position the UK at the forefront of international stem cell science and provide important new opportunities for development of new therapies.

Organisations

Publications

10 25 50
 
Description BMJ Editorial on stem cells in MS, 2010
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact NK
 
Description Book chapter on human-animal chimeras, collaboration with Neville Cobbe.
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact NK
 
Description CFFC - gave presentation at workshop on Regenerative Medicine at the House of Lords, 23rd Oct, Charles ffrench-Constant
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description Characterisation of large pre-existing hybridoma panel on human and zebrafish embryonic tissue, funding in place from Bioquarter (UoE/SE) to characterise antibodies particularly with regard to those recognising lineage markers in zebrafish, antibodies to be freely available to zebrafish community and hybridomas to be licensed by UoE.
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact antibodies to be freely available to zebrafish community and hybridomas to be licensed by UoE. Possible contribution to spin-out company from UoE
 
Description Development of multi-modal contrast agents for imaging and gene delivery
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact available to research community, collaborators in Edinburgh include CVS, CRB
 
Description Inverkeithing High School and others very keen to repeat the SSCN roadshow and for it to become a regular part of the school's commitment to the curriculum for excellence
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
Impact Public outreach
 
Description Monthly MS Discussion Group for Neurologists in SE Scotland
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
Impact Discussion of clinical cases, current research etc. 2008-continues. Very successful in providing clinical support, propagating important research findings and general clinical policies throughout our catchment area.
 
Description Myelinating co-culture technologies
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Myelinating co-culture technologies, for which we receive at least one request/month for protocols or training
 
Description Participation in British Council funded Latin America PhD student course 'ES cells as a model system for embryonic development' in Sao Paulo, Brazil [February 2009].
Geographic Reach North America 
Policy Influence Type Influenced training of practitioners or researchers
Impact NK
 
Description Prevalence register for patients in Scotland.
Geographic Reach National 
Policy Influence Type Citation in other policy documents
Impact Have contributed to the momentum that led to the Scottish Governments agreement to fund a prevalence register for patients in Scotland.
 
Description Research materials.
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact Research materials.
 
Description Scientific Advisory Board for the Scottish Universities Environmental Research Centre (SUERC)
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in advisory committee
Impact Appointed to the Scientific Advisory Board for the Scottish Universities Environmental Research Centre (SUERC) from 2010.
 
Description Wellcome ERG
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
 
Description 089000/Z/09/Z Wellcome Trust Programme Grant (Axoglial interactions during myelination in the CNS) PIs Brophy and French-Constant
Amount £1,610,619 (GBP)
Funding ID 089000/Z/09/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2008 
End 07/2013
 
Description AHMRC CJ Martin Fellowship /AHMRC
Amount £1 (GBP)
Organisation National Health and Medical Research Council 
Sector Public
Country Australia
Start 05/2009 
End 04/2012
 
Description ALLOSTEM: The Development of Immunotherapeutic Strategies to Treat Haematological and Neoplastic diseases on the Baiss of Optimised Allogeneic Stem Cell Transplantation (8m euros across 29 participants)
Amount £13,000 (GBP)
Funding ID 503319 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 04/2004 
End 03/2008
 
Description Analysis of cellular mechanisms underlying haematopoietic
Amount £1 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description BBSRC Stem Cells Initiative Project Grant
Amount £1 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description BBSRC funding (Generating models of nurtitional programming)
Amount £1,300,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 05/2009 
End 04/2014
 
Description BEST-Stem Cells: Bio-chemically Equivalent Substitutive Technology for Stem Cells (MGMT-budget CMVM)
Amount £300,000 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 07/2009 
End 06/2012
 
Description BEST-Stem Cells: Bio-chemically Equivalent Substitutive Technology for Stem Cells (RTD-budget CMVM)
Amount £650,000 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 07/2009 
End 06/2012
 
Description BHF Project Grant
Amount £1 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description BHF Project Grant PG/05/077/18240 (Mechanisms of acclerated atherogenesis and sudden death in an ApoE-/- / 11HSD2-/- double knockout mouse) PI Dr Y V Kotelevtsev
Amount £184,858 (GBP)
Funding ID PG/05/077/18240 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2004 
End 12/2006
 
Description Biotechnology and Biological Sciences Research Council (BBSRC)-Identification of Functional Domains in the AGM Region linked to the hierarchical organisation of the developing haematopoietic stem cell lineage
Amount £1,600,000 (GBP)
Organisation CHDI Foundation 
Sector Charity/Non Profit
Country United States
Start 09/2010 
End 08/2013
 
Description Biotechnology and Biological Sciences Research Council (BBSRC)-Integrating developmental pathways and chromatin structure during lineage specification
Amount £460,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Biotechnology and Biological Sciences Research Council (BBSRC)-Steroid Receptors and transcriptional control of thymic rebound
Amount £600,000 (GBP)
Funding ID BB/H021183/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2010 
End 08/2013
 
Description CASE Studentship (Stem Cell Sciences)/stem cell sciences
Amount £1 (GBP)
Organisation Babraham Institute 
Department Stem Cell Sciences UK Ltd
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Cancer Research UK-Function of the C/EBPâ-CyclinD1 complex in epithelial cancers
Amount £275,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2010 
End 04/2013
 
Description Cancer Research UK-Identification of genes required for the maintenance of AML cancer stem cells
Amount £300,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2010 
End 09/2013
 
Description Daphne Jackson Trust-Fellowship for Joanna Brzeszcyzynska: miRNAs role in muscle pathphysiology of cancer cachexia
Amount £41,000 (GBP)
Organisation University of Surrey 
Department Daphne Jackson Trust
Sector Charity/Non Profit
Country United Kingdom
Start 10/2010 
End 09/2013
 
Description EPSRC funding (Screening polymer libraries using hESC-derived hepatic endoderm)
Amount £250,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description ESTOOLS (12m euros across 23 participants)
Amount £427,826 (GBP)
Funding ID 18739 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 07/2006 
End 07/2010
 
Description EU Consortium for Stem Cell Biology
Amount £1 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 05/2009 
End 04/2012
 
Description EU Consortium for Stem Cell Biology/EU Consortium
Amount £1 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 05/2009 
End 04/2012
 
Description EUROSTEMCELL-European consortium for communication of stem cell research/eurostemcell (0.8m euros across 11 participants)
Amount £61,890 (GBP)
Funding ID 241878 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 03/2010 
End 02/2014
 
Description Engineering and Physical Sciences Research Council (EPSRC)-Bio-Active Polymer Driven Cell Based Systems - Predicting Human Drug Toxicity
Amount £130,000 (GBP)
Funding ID EP/H029680/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description European Commission (EC)-EuroStemCell: European Consortium for Communicating Stem Cell Research/euorpean commission (EC)
Amount £516,000 (GBP)
Funding ID 241878 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 09/2010 
End 08/2013
 
Description European Commission/Marie Curie - Intra-European Fellowship-GRNES: Analysis of the gene regulatory network controlling ES cell identity/European Commission/Marie Curie - Intra-European Fellowship
Amount £140,000 (GBP)
Funding ID 254979 
Organisation Marie Sklodowska-Curie Actions 
Sector Academic/University
Country Global
Start  
 
Description Foreign & Commonwealth Office-UK-US Stem Cell Collaboration Award/Foreign & Commonwealth Office
Amount £2,400 (GBP)
Organisation Foreign and Commonwealth Office (FCO) 
Sector Public
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Gamma irradiation sources for studies on stem cell and immune cell function
Amount £1 (GBP)
Funding ID 084537 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Generating models of hepatic endoderm from hESCs suitable for industrial application
Amount £180,000 (GBP)
Organisation Stem Cells for Safer Medicines (SC4SM) 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description JDRF Pilot Project
Amount £1 (GBP)
Organisation Juvenile Diabetes Research Foundation (JDRF) 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description JDRF Pilot Project
Amount £1 (GBP)
Organisation Juvenile Diabetes Research Foundation (JDRF) 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Knowledge Transfer Partnership-Estimate of 2 year project between Roslin Cellab and University of Edinburgh/knowledge transfer partnership
Amount £95,000 (GBP)
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 10/2010 
End 09/2012
 
Description LRF Project Grant
Amount £1 (GBP)
Organisation Leukaemia and Lymphoma Research 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description LRF Senior Fellowship
Amount £1 (GBP)
Organisation Leukaemia and Lymphoma Research 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Leukaemia Research (Directing differentiation of Mouse and human embryonic stem cells into haematopoietic stem cells (HSC) using engineered embryonic HSC niches)
Amount £1,350,000 (GBP)
Organisation Leukaemia and Lymphoma Research 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Leukaemia Research (Ex vivo expansion of human haematopoietic stem cells from the embryonic AGM region)
Amount £219,600 (GBP)
Organisation Leukaemia and Lymphoma Research 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2008 
End 04/2011
 
Description Leukaemia Research Foundation-In vitro propagation of mouse and human fetal thymic epithelial progenitor cells/Leukaemia Research Foundation
Amount £190,000 (GBP)
Organisation Leukaemia and Lymphoma Research 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2010 
End 04/2013
 
Description Leukaemia Research Foundation-Molecular and Cellular Analysis of Thymic Epithelial Progenitor Cells
Amount £40,000 (GBP)
Organisation Leukaemia and Lymphoma Research 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description MRC Collaborative Studentship (partner Stem Cell Sciences)
Amount £1 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description MRC Project Grant (G0400690)
Amount £1 (GBP)
Funding ID G0400690 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description MRC Research Grant (Studying transplantation of hESC-derived hepatic endoderm into animal models)
Amount £500,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description MRC iPS supplemental award
Amount £50,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description MS Hope For A Cure-Autologous cell therapy - a neuroprotective strategy for MS/MS Hope for a Cure
Amount £51,500 (GBP)
Organisation MS Hope for a Cure 
Sector Charity/Non Profit
Country United States
Start 05/2009 
End 04/2012
 
Description Marie Curie Initial Training Network NotchIT
Amount £310,000 (GBP)
Funding ID 215761 
Organisation Marie Sklodowska-Curie Actions 
Sector Academic/University
Country Global
Start 05/2009 
End 04/2012
 
Description Medical Research Council (MRC)-ANALYSIS OF MECHANISMS OF EARLY HAEMATOPOIETIC STEM CELL DEVELOPMENT CONTROLLED BY FLK1/SCL REGULATORY NETWORK
Amount £300,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2010 
End 09/2013
 
Description Medical Research Council (MRC)-ANALYSIS OF MECHANISMS OF EARLY HAEMATOPOIETIC STEM CELL DEVELOPMENT CONTROLLED BY FLK1/SCL REGULATORY NETWORK
Amount £1,530,000 (GBP)
Funding ID G0900962 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2010 
End 04/2013
 
Description Medical Research Council (MRC)-Centre Grant: MRC UoE Centre for Inflammation Research
Amount £1,510,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2010 
End 04/2013
 
Description Medical Research Council (MRC)-Characterisation and culture of neuromesodermal stem cells
Amount £650,000 (GBP)
Funding ID G0802097 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Medical Research Council (MRC)-Clinical Training Fellowship for Mike Williams: Defining the functional role of the progenitor cell-laminin interaction during liver regeneration
Amount £290,000 (GBP)
Funding ID G0900446 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2010 
End 04/2013
 
Description Medical Research Council (MRC)-Development of Retinal Transplantation as an Animal Model to Test Stem Cell Therapies for Myelin Diseases
Amount £330,000 (GBP)
Funding ID G0802545 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Medical Research Council (MRC)-Development of a non-invasive strategy enhancing haematopoietic stem cell (HSC) potential of human umbilical cord cells
Amount £870,000 (GBP)
Funding ID G0901577 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2010 
End 09/2013
 
Description Medical Research Council (MRC)-Strategic Appointment of Dr Nerlov
Amount £620,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Medical Research Council (MRC)-Transcriptional regulation of hematopoietic self-renewal, lineage specification and leukemogenesis
Amount £2,100,000 (GBP)
Funding ID G0900892 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2010 
End 04/2013
 
Description Medical Research Council (MRC)-Transfer of Millstein Award from the University of Cambri
Amount £190,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2009 
End 05/2012
 
Description Motor Neurone Disease Association-Modelling motor neuron disease using induced pluripotential stem cells.
Amount £800,000 (GBP)
Organisation Motor Neurone Disease Association (MND) 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2010 
End 08/2013
 
Description Multiple Sclerosis Society-Autologous adult human mesenchymal stem cells: a neuroprotective therapy for MS - supplement
Amount £49,000 (GBP)
Organisation Multiple Sclerosis Society 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2010 
End 04/2013
 
Description Multiple Sclerosis Society-Identification of Inflammatory Cytokines that Promote Myelination and Remyelination
Amount £410,000 (GBP)
Funding ID 891 
Organisation Multiple Sclerosis Society 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description NIH Program Project Grant PO1/NIH
Amount £1 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 05/2009 
End 04/2012
 
Description NIH Programme Project-Mechanisms Controlling Thymic Homeostasis, Involution, and Rebound.(co applicant potion given)/NIH Programme Project
Amount £32,000 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 05/2009 
End 04/2012
 
Description Notch signalling in developmental specification of haematopoietic stem cells
Amount £490,000 (GBP)
Organisation Melville Trust for Care and Cure of Cancer 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Ontogeny of haematopoietic stem cells
Amount £1 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Optistem - Optimization of Stem Cell therapy for clinical trials degenerative skin and muscle disease (12m euros across 18 participants)
Amount £1,100,000 (GBP)
Funding ID 223098 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2009 
End 12/2013
 
Description Parkinson's Disease UK-Generation of induced pluripotent stem cells from people with Parkinson's disease.
Amount £370,000 (GBP)
Funding ID H-1002 
Organisation Parkinson's UK 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Parkinson's Disease UK-Role of FGF signalling in maintenance and differentiation of human pluripotent cells.
Amount £31,500 (GBP)
Organisation Parkinson's UK 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Pfizer Ltd-Neural induction of mouse and embryonic stem cells - studentship Agnieszka Paca
Amount £25,500 (GBP)
Organisation Pfizer Ltd 
Sector Private
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description RCUK Fellowship
Amount £1 (GBP)
Organisation Research Councils UK (RCUK) 
Sector Public
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Role fo AML1/Runx1 isoforms in development
Amount £1 (GBP)
Funding ID G0500950 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Royal Society/Newton International Fellowship-Pablo Navarro's Newton International Fellowship: Analysis of the gene regulatory network controlling ES cell identity
Amount £100,000 (GBP)
Organisation The Royal Society 
Sector Academic/University
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Scottish Biomedical Research Trust-Studentship in Biomedical Research/Scottish Biomedical Research Trust
Amount £400 (GBP)
Organisation SB Drug Discovery 
Sector Private
Country United Kingdom
Start 05/2010 
End 04/2013
 
Description Scottish Biomedical Research Trust-Studentship in Biomedical Research/Scottish Biomedical Turst
Amount £3,000 (GBP)
Organisation SB Drug Discovery 
Sector Private
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Scottish Executive Pilot Study
Amount £1 (GBP)
Organisation Government of Scotland 
Sector Public
Country United Kingdom
Start 05/2010 
End 04/2013
 
Description Scottish Motor Neurone Disease Association-Scottish MND register - a prospective and collaborative platform for improved care, prognostic modelling, research and clinical trials./Scottish Motor Neurone Disease Association
Amount £199,000 (GBP)
Organisation MND Scotland 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2010 
End 04/2013
 
Description Scottish National Blood Transfusion Service-Proof of principle: human embryonic stem cell derived red cell concentrates for clinical transfusion/Scottish National Blood Transfusion Service
Amount £340,000 (GBP)
Organisation NHS National Services Scotland (NSS) 
Department Scottish National Blood Transfusion Service
Sector Public
Country United Kingdom
Start 05/2009 
End 04/2013
 
Description Sir Jules Thorn Trust Award (£1.1M National reseach competition), 2007
Amount £1,100,000 (GBP)
Organisation Sir Jules Thorn Charitable Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2007 
End 04/2010
 
Description Stem Cell Research Foundation (USA)
Amount £1 (GBP)
Organisation Bedford Stem Cell Research Foundation 
Sector Charity/Non Profit
Country United States
Start 05/2009 
End 04/2012
 
Description The Order of Malta "France"-Insights from m. Leprae-induced early demyelination: towards predictive and therapeutic targets for leprosy nerve damage/The Order of Malta "France"
Amount £29,000 (GBP)
Organisation Order of Malta 
Department French Association of the Order of Malta
Sector Public
Country France
Start 05/2010 
End 04/2013
 
Description University College London-Comparing and contrasting the gene expression phenotype of dopamine neurons derived from stem cells with that from the human substantia nigra/University College London
Amount £10,000 (GBP)
Organisation University College London 
Sector Academic/University
Country United Kingdom
Start 05/2010 
End 04/2013
 
Description University of Cambridge-Transfer of Funds - David Hampton/University of Cambridge
Amount £72,000 (GBP)
Organisation University of Cambridge 
Sector Academic/University
Country United Kingdom
Start 10/2010 
End 09/2013
 
Description University of Cambridge-Transfer of MRC Award from Cambridge: Integrin Engineering to Promote Axon Regeneration and Schwann Cell Migration/University of Cambridge
Amount £410,000 (GBP)
Organisation University of Cambridge 
Sector Academic/University
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description University of Cambridge-Transfer of MS Society Grant from Cambridge: Costs for A Jarjour/University of Cambridge
Amount £220,000 (GBP)
Organisation University of Cambridge 
Sector Academic/University
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description University of Cambridge-Transfer of MS Society Grant from Cambridge: Costs for A Jarjour/University of Cambridge
Amount £72,000 (GBP)
Organisation Multiple Sclerosis Society 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2010 
End 04/2013
 
Description University of Georgia-Mechanisms controlling theymic homeostasis, involution and rebound. Core Grant/University of Georgia
Amount £15,000 (GBP)
Organisation University of Georgia 
Sector Academic/University
Country United States
Start 09/2010 
End 08/2013
 
Description University of Georgia-Mechanisms controlling theymic homeostasis, involution and rebound. Core Grant/University of Georgia
Amount £31,000 (GBP)
Organisation University of Georgia 
Sector Academic/University
Country United States
Start 05/2009 
End 04/2012
 
Description VIP Award
Amount £1 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description WT Society Award
Amount £1 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description WT Studentship
Amount £1 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description WT Studentship
Amount £1 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description WT VIP award
Amount £1 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2010 
End 04/2013
 
Description WT Vacation Scholarship
Amount £1 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Wellcome Trust-Advanced FACS equipment for stemcell research
Amount £830,000 (GBP)
Funding ID 087371 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Wellcome Trust-CAT: Morley: Novel Ligands for Fluorescent Imaging of Breast and Ovarian Cancer in Mouse Models (Brunton)
Amount £290,000 (GBP)
Funding ID 094416 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Wellcome Trust-Comparative genomics of the inflammatory response
Amount £270,000 (GBP)
Funding ID 090385 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Wellcome Trust-ECAT - Support for Piloting Virtual and Face to face Catalysts to Enthuse, Recruit and Retain the Most Able Clinical Academic Trainees
Amount £16,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Wellcome Trust-ECAT: Aldridge: The Role of CDK11 - Mediated Autophagy in Tumour Cells and the Impact of Dysregulation on Tumourgenesis (Frame)
Amount £240,000 (GBP)
Funding ID 094414 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2010 
End 08/2013
 
Description Wellcome Trust-ECAT: Lucas: Modulation of Inflammatory Cell Apoptosis in Infectious Lung Injury (Rossi)
Amount £225,000 (GBP)
Funding ID 094415 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2010 
End 09/2013
 
Description Wellcome Trust-ECAT: O'Neill: Can Mitotic Kinases be Expolited as Drug Targets in Oseophageal Adenocarcinoma? (Hupp)
Amount £230,000 (GBP)
Funding ID 094417 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2010 
End 08/2013
 
Description Wellcome Trust-ECAT: Sokhi: Developmental Genetics Analysis of Post-Axial Transverse Limb Reduction deformity (PATLRD) (FitzPatrick, MRC HGU)
Amount £230,000 (GBP)
Funding ID 094418 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2010 
End 08/2013
 
Description Wellcome Trust-Structural and functional changes in the distal convoluted tubules of the kidney in mouse models of hypertension
Amount £250,000 (GBP)
Funding ID 090387 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Wellcome Trust-The Src and FAK families of non-receptor tyrosine kinases in primary brain tumours
Amount £260,000 (GBP)
Funding ID 090386 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Wellcome Trust-Vacation Scholarship for James Beggs:
Amount £1,500 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Wellcome Trust-Vacation Scholarship for Jayanthi Sethunarayanan: of â-globin expression in HoxB4 overexpressed muring and human embryonic stem
Amount £1,400 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2010 
End 08/2013
 
Description Wellcome Trust-Vacation Scholarship for Susanne Maxwell:
Amount £1,500 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Description Wellcome Trust-WT1 in the kidney: Regulation of the epithelial - mesenchymal balance
Amount £270,000 (GBP)
Funding ID 090388 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 04/2012
 
Title DNA vectors 
Description DNA vectors 
Type Of Material Cell line 
Year Produced 2009 
Provided To Others? Yes  
Impact NK 
 
Title Development of a Fourier domain optical coherence tomography instrument 
Description Development of a Fourier domain optical coherence tomography instrument (available at SEE, Used by prof. Davis group, Prof. Tabrizian group) 
Type Of Material Improvements to research infrastructure 
Year Produced 2009 
Provided To Others? Yes  
Impact available at SEE, Used by prof. Davis group, Prof. Tabrizian group 
 
Title Development of optical coherence phase microscope 
Description Development of optical coherence phase microscope (available at SEE) 
Type Of Material Improvements to research infrastructure 
Year Produced 2009 
Provided To Others? Yes  
Impact available at SEE, 
 
Title Gene targeted Human ES cell reporter lines (OC-4, SOX-2, KLF-4) 
Description Gene targeted Human ES cell reporter lines (OC-4, SOX-2, KLF-4) provided to Sheffield (Peter Andrews) and Cambridge (Austin Smith) as part of ESTOOLS Consortium Project. 
Type Of Material Cell line 
Year Produced 2009 
Provided To Others? Yes  
Impact provided to Sheffield (Peter Andrews) and Cambridge (Austin Smith) 
 
Title IHMED MS database 
Description Involved in setting up of the IHMED MS database for both research and clinical care of MS patients. 
Type Of Material Database/Collection of Data/Biological Samples 
Provided To Others? No  
Impact nk 
 
Title Methods for label-free real-time monitoring of stem cell differentiation with electric-cell impedance sensing 
Description Methods for label-free real-time monitoring of stem cell differentiation with electric-cell impedance sensing (available in the centre, provided to Paul de Sousa Group, Dr Hay group) 
Type Of Material Technology assay or reagent 
Year Produced 2009 
Provided To Others? Yes  
Impact available in the centre, provided to Paul de Sousa Group, Dr Hay group 
 
Title Microarray gene expression profile of inflammation in retina 
Description Microarray gene expression profile of inflammation in retina, provided to myelin biology consortium based in San Francisco, part of submitted manuscript 
Type Of Material Technology assay or reagent 
Year Produced 2009 
Provided To Others? Yes  
Impact provided to myelin biology consortium based in San Francisco, part of submitted manuscript 
 
Title Myelinating co-culture systems to analyse effects of signalling molecules on myelination 
Description Myelinating co-culture systems to analyse effects of signalling molecules on myelination, have trained visiting scientists from Holland and Portugal, essential part of work in Nature Neuroscience 
Type Of Material Technology assay or reagent 
Year Produced 2009 
Provided To Others? Yes  
Impact have trained visiting scientists from Holland and Portugal, essential part of work in Nature Neuroscience 
 
Title Non-viral iPSC lines 
Description mouse iPS cell lines, generated via pCAG2LMKOSimO 
Type Of Material Cell line 
Year Produced 2009 
Provided To Others? Yes  
Impact ecause reprogramming factors(Oct4, Sox2, Klf4 and c-Myc) had been excised from the iPSC lines using Cre-recombinase, we do not need to worry about influence of exogenous factors which remain in iPSCs generated with retroviral vectors. 
 
Title Novel ex vivo HSC generation system 
Description We developed a culture system of embryonic AGM region cells which after reaggregation resume generation of the HSC development. This enables analysis of of individual cell populations in HSC development to be performed. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Provided To Others? No  
Impact Elucidating the mechanisms underlying HSC specification and expansion in the embryo have been hampered by the lack of analytical cell culture systems that recapitulate in vivo development. We developed a novel ex vivo model that facilitates a rapid and robust emergence of multipotent longterm repopulating HSCs in the embryonic AGM region and enables analysis of individual cell populations involved in this process to be performed. Using this model, we established the identity of preHSCs which mature into definitive HSCs. The importance of this study is dual i) it will shed light on one of the central problems of HSC biology, namely, genetic regulation of early HSC development and ii) provide mechanistic data for potential development of clinically relevant protocols aiming to enhance production of haematopoietic progenitors and stem cells in vitro. 
 
Title Remyelinating CNS slice culture system 
Description Remyelinating CNS slice culture system. Semi-automated system to study and measure remyelination in CNS ex vivo cultures. 
Type Of Material Technology assay or reagent 
Year Produced 2009 
Provided To Others? Yes  
Impact Paper submitted to the journal "Brain". Method taught to lab in Glasgow. Interest from company called Vaccinex, in the US. 
 
Title Runx1 reversible knockout/ reporter mouse 
Description A multifunctional reversible knockout/ reporter system enabling fully functional reconstitution of the AML1/Runx1 locus and rescue of haematopoiesis 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2006 
Provided To Others? Yes  
Impact Analysis of these mice was an important tool used in publication: N. Stifaniet al(2008) "Suppression of interneuron programs and maintenance of selected spinal motor neuron fates by the transcription factor AML1/Runx1. Proc Natl Acad Sci USA 105, No 17, 64516456 
 
Title Tetracyclineinducible Runx1 (short and long isoform) transgenic mice 
Description These transgenic mice allow upregulation of short and long Runx1 isoforms in mice 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2007 
Provided To Others? Yes  
Impact These mice were analysed by our collaborators which resulted in publication: Aldskogius, et al . "Regulation of Boundary Cap Neural Crest Stem Cell Differentiation after Transplantation" Stem Cells 27, 15921603 
 
Title pCAF2LMKOSimO 
Description a single non-viral reprogramming vector, encoding c-Myc, Klf4, Oct4, Sox2 and mOrange 
Type Of Material Cell line 
Year Produced 2009 
Provided To Others? Yes  
Impact It allowed the generation of induced pluripotent stem cells without viral vectors 
 
Title purification of transcription factors 
Description the method for purification of transcription factors developed in collaboration with R.Poot and detailed in paper van den Berg, D.L.C., Snoek, T., Mullin, N.P., Yates, A., Bezstarosti, K., Demmers, J. Chambers, I. and Poot, R.A. (2010) An Oct4-centred protein interaction network in embryonic stem cells. Cell Stem Cell, 6, 369-381. is a major advance in the field and we expect this to be widely taken up. 
Type Of Material Technology assay or reagent 
Year Produced 2009 
Provided To Others? Yes  
Impact Expectation that this will be widely taken up 
 
Description AM Collaboration with NIMR 
Organisation Medical Research Council (MRC)
Department MRC National Institute for Medical Research (NIMR)
Country United Kingdom 
Sector Public 
PI Contribution NK
Collaborator Contribution Research output
Impact NK
 
Description AM Collaboration with Uppsala 
Organisation Uppsala University
Country Sweden 
Sector Academic/University 
PI Contribution NK
Impact NK
Start Year 2007
 
Description AM collaboration with McGill University 
Organisation McGill University
Country Canada 
Sector Academic/University 
PI Contribution NK
Collaborator Contribution Research output
Impact NK
 
Description AS Collaboration with MRC MHU 
Organisation Medical Research Council (MRC)
Department MRC Molecular Haematology Unit
Country United Kingdom 
Sector Public 
PI Contribution NK
Collaborator Contribution Research output
Impact NK
 
Description Analysis of use of alternative promoters for Runx1 
Organisation University of Oxford
Department Oxford Stem Cell Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution We provided our Runx1 reactivatable knockout mouse model to Dr Marella de Bruijn
Collaborator Contribution Use of different Runx1 promoters is related to production of short and long Runx1 isoforms
Impact This collaboration resulted in publication: T. Bee, et al. (2009). Alternative Runx1 promoter usage in mouse developmental hematopoiesis. Blood Cells Mol. Dis. 43, 3542
Start Year 2007
 
Description Bernard Roelen (Utrecht)-Investigation of Nanog expression in testes. 
Organisation Utrecht University
Country Netherlands 
Sector Academic/University 
PI Contribution Investigation of Nanog expression in testes. Supported by funding from WT.
Collaborator Contribution Research output
Impact Kuijk, E.W., de Gier, J., Chuva de Sousa Lopes, S.M., Chambers, I., van Pelt, A.M.M., Colenbrander, B., Roelen, B.A.J. (2010) A distinct pattern in mammalian testes indicates a conserved role for Nanog in spermatogenesis. PloS One, 5, e10987.
Start Year 2009
 
Description CB Collaboration with Erasmus Rotterdam 
Organisation Erasmus University Rotterdam
Country Netherlands 
Sector Academic/University 
PI Contribution NK
Impact NK
 
Description CB Collaboration with Hull/York 
Organisation Hull York Medical School
Country United Kingdom 
Sector Academic/University 
PI Contribution NK
Impact NK
Start Year 2007
 
Description CB Collaboration with ISCR Edinburgh 
Organisation University of Edinburgh
Department Institute of Stem Cell Research Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution NK
Collaborator Contribution Research output
Impact NK
 
Description CB Collaboration with MD Anderson Cancer Centre 
Organisation University of Texas
Department M. D. Anderson Cancer Center
Country United States 
Sector Academic/University 
PI Contribution Development of joint research project. Participation in closed symposia for award holders.
Collaborator Contribution Development of joint research project.
Impact NK
Start Year 2006
 
Description CB Collaboration with NIMR 
Organisation Medical Research Council (MRC)
Department MRC National Institute for Medical Research (NIMR)
Country United Kingdom 
Sector Public 
PI Contribution NK
Impact NK
Start Year 2007
 
Description CB Collaboration with Stem Cell Sciences 
Organisation Babraham Institute
Department Stem Cell Sciences UK Ltd
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution BBSRC CASE studentship (entered under further funding)
Impact NK
 
Description CCBS, University of Edinburgh -Second supervisor to PhD student, . Funding from CCBS. 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Second supervisor to PhD student, . Funding from CCBS.
Collaborator Contribution Research output
Impact paper in "Multiple Sclerosis"
Start Year 2009
 
Description CIR, University of Edinburgh -Shared PhD student on Tregs in CNS remyelinations, with PhD studentship from the SCRM. 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Shared PhD student on Tregs in CNS remyelinations, with PhD studentship from the SCRM.
Collaborator Contribution Research output
Impact NK
Start Year 2010
 
Description CNR, University of Edinburgh-Shared PhD student on the "MS zebrafish", funded by the CCBS. 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Shared PhD student on the "MS zebrafish", funded by the CCBS.
Collaborator Contribution Research output
Impact NK
Start Year 2010
 
Description Cambridge University-Biology of Nanog. 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Biology of Nanog. Supported by funding from WT.
Collaborator Contribution Research output
Impact Silva, J., Nichols, J., Theunissen, T.W., Guo, G., van Oosten, A.L., Barrandon, O., Wray, J., Yamanaka, S., Chambers, I. and Smith, A. (2009) Nanog is the gateway to the pluripotent ground state. Cell 138, 722-737.
 
Description Cellartis-Petter Bjorquist 
Organisation Cellartis AB
Country Sweden 
Sector Private 
PI Contribution Petter Bjorquist
Collaborator Contribution research output
Impact Work in progress
Start Year 2010
 
Description Daphne Jackson Fellowship-Joanna Brzeszczynska (2010-2012) sponsored by the Leverhulme Trust. Role of miRNAs in muscle pathophysiology. 
Organisation University of Surrey
Department Daphne Jackson Trust
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Joanna Brzeszczynska (2010-2012) sponsored by the Leverhulme Trust. Role of miRNAs in muscle pathophysiology.
Collaborator Contribution Research output
Impact NK
Start Year 2010
 
Description Development of AGM reaggregation system 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Developed a new powerful analytical system enabling generation of HSCs ex vivo
Collaborator Contribution Novel protocol for thymus reaggregation technique was provided to us which further refined by us resulted in development of a new powerful ex vivo HSC expansion analytical system
Impact Two publications in prestigeous Cell Stem Cell magazine and Genesis: 1. S. Taoudi et al. (2008) Extensive hematopoietic stem cell (HSC) generation in the AGM region via maturation of VEcadherin+ CD45+ predefinitive HSCs. Cell Stem Cell 3, 99108 2. J. Sheridan et al., "A novel method for the generation of reaggregated organotypic cultures that permits juxtaposition of defined cell populations" Genesis 47, 34651
Start Year 2006
 
Description EU FP6 Consortium Project 'ESTOOLS' -'Recombination Tools and Genetic Switches' 
Organisation European Commission
Department EC FP6 Collaborative Projects
Country European Union (EU) 
Sector Academic/University 
PI Contribution Human ES Cell Genetic Manipulation - 'Recombination Tools and Genetic Switches'. EU involving collaborations with groups in Bonn (Frank Edenhofer), Dresden (Konstantinos Anastassiadis), Sheffield (Peter Andrews). Entirely EU funded but involved expertise and participation FP6 Consortium Project 'ESTOOLS' [August 2006 - August 2010] of MRC Centre Human ES Cell Facility Manager (Judy Flertcher) for work done in Edinburgh University.
Collaborator Contribution Research output
Impact NK
Start Year 2006
 
Description Erasmus, Rotterdam-Investigation of protein-protein interactions in pluripotent cells. 
Organisation Erasmus University Rotterdam
Country Netherlands 
Sector Academic/University 
PI Contribution Begun approximately 2005. Investigation of protein-protein interactions in pluripotent cells. Supported by funding from WT.
Collaborator Contribution Research output
Impact van den Berg, D.L.C., Zhang, W., Yates, A., Engelen, E., Takacs, K., Bezstarosti, K., Demmers, J. Chambers, I. and Poot, R.A. (2008) The Estrogen Related Receptor Beta interacts with Oct4 to positively regulate Nanog gene expression. Mol. Cell. Biol., 28, 5986-5995 & van den Berg, D.L.C., Snoek, T., Mullin, N.P., Yates, A., Bezstarosti, K., Demmers, J. Chambers, I. and Poot, R.A. (2010) An Oct4-centred protein interaction network in embryonic stem cells. Cell Stem Cell, 6, 369-381.
 
Description Further development of proteomic and molecular markers of muscle loss. 
Organisation Novartis
Country Global 
Sector Private 
PI Contribution further development of proteomic and molecular markers of muscle loss.
Collaborator Contribution Research output
Impact Contract under discussion
Start Year 2010
 
Description Generating models of hepatic endoderm from hESCs suitable for industrial application 
Organisation Stem Cells for Safer Medicines (SC4SM)
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Collaboration with Josh Brickman in generating models of hepatic endoderm from hESCs suitable for industrial application
Collaborator Contribution Collaboration in generating models of hepatic endoderm from hESCs suitable for industrial application
Impact Grant awarded 2009 £180k - Stem Cells for Safer Medicine
Start Year 2008
 
Description Generating models of nutritional programming 
Organisation University of Nottingham
Department School of Clinical Sciences Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration with Lorraine Young generating models of nutritional programming
Collaborator Contribution Collaboration in generating models of nutritional programming
Impact BBSRC grant awarded 2009 £1.3m
Start Year 2009
 
Description Hellmholtz, Munich-Live cell imaging analysis of pluripotent cells. 
Organisation Helmholtz Association of German Research Centres
Department Helmholtz Centre for Infection Research (HZI)
Country Germany 
Sector Public 
PI Contribution Live cell imaging analysis of pluripotent cells. Supported by funding from HFSP.
Collaborator Contribution Research output
Impact Grant funded; 2010-2013 HFSP Programme grant (IC, lead PI) "A microfluidic, small molecule approach to perturbation of the pluripotency transcription network." I.Chambers, T.Schroeder, T.Wandless & L.Lee. $1,200,000 US
Start Year 2010
 
Description IRME, Paris, France -Catherine Lubetzki, IRME, Paris, France - started 2006. 
Organisation Institute for Research on the Spinal Cord and Brain (IRME)
Country France 
Sector Public 
PI Contribution Catherine Lubetzki, IRME, Paris, France - started 2006.
Collaborator Contribution Research output
Impact Paper under review at the journal "Brain."
Start Year 2006
 
Description IRME, Paris, France-Paper accepted in Annals of Neurology. 
Organisation Institute for Research on the Spinal Cord and Brain (IRME)
Country France 
Sector Public 
PI Contribution Paper accepted in Annals of Neurology.
Collaborator Contribution Research output
Impact Paper accepted in Annals of Neurology.
Start Year 2008
 
Description Ian Wark institute, Adelaide, Australia-Assessing nanoparticles cytotoxicity on stem cells with impedance sensing. 
Organisation University of South Australia
Department Ian Wark Institute
Country Australia 
Sector Academic/University 
PI Contribution Ongoing: Assessing nanoparticles cytotoxicity on stem cells with impedance sensing.
Collaborator Contribution Research output
Impact Work presented at Biosensors 2010, Glagow. Manuscript in preparation.
Start Year 2010
 
Description Institut Pasteur, Paris-Investigation of pluripotency factor function in epigenetic mechanisms of X-inactivation. 
Organisation Pasteur Institute, Paris
Country France 
Sector Academic/University 
PI Contribution Begun approximately 2005. Investigation of pluripotency factor function in epigenetic mechanisms of X-inactivation. Supported by funding from WT & EuroSyStem.
Collaborator Contribution Research output
Impact Navarro, P., Chambers, I., Karwacki-Neisius, V., Chureau, C., Morey, C., Rougelle, C. and Avner, P. (2008) Direct molecular coupling of Xist regulation and pluripotency. Science, 321, 1693-1695 Cited in Faculty of 1000: http://www.f1000biology.com/article/id/1124285/evaluation & Navarro, P., Oldfield, A., Legoupi, J., Festuccia, N., Dubois, A., Attia, M., Rougeulle, C., Chambers, I. and Avner, P. Molecular coupling of Tsix regulation and pluripotency. Accepted at Nature.
 
Description Jacqueline Deschamps- Cdx2 and axial progenitors. 
Organisation Royal Netherlands Academy of Arts and Sciences
Department Hubrecht Institute
Country Netherlands 
Sector Academic/University 
PI Contribution Collaboration with Jacqueline Deschamps on Cdx2 and axial progenitors.  Started 2006,   Funded by BBSRC and MRC.
Collaborator Contribution Research output
Impact paper in Dev Biol 2010.
Start Year 2006
 
Description Jean-François Nicolas and Elena Tzouanacou -clonal lineage analysis, 
Organisation Pasteur Institute, Paris
Country France 
Sector Academic/University 
PI Contribution Collaboration with Jean-Francois Nicolas and Elena Tzouanacou on clonal lineage analysis,   Funded by FPV network Eurostemcell and BBSRC
Collaborator Contribution Research output
Impact paper in Dev Cell 2009.
Start Year 2009
 
Description Lamellar Biomedical Ltd.-Consultancy, progress toward clinical trials, treatment for secretory disorders. 
Organisation Lamellar Biomedical Ltd
Country United Kingdom 
Sector Private 
PI Contribution Consultancy, progress toward clinical trials, treatment for secretory disorders.
Collaborator Contribution CSO bid being asembled
Impact CSO bid being asembled
Start Year 2009
 
Description Leicester-analysis of cytoskeletal function in myelination, 
Organisation University of Leicester
Department Department of Molecular and Cell Biology
Country United Kingdom 
Sector Academic/University 
PI Contribution David Critchley (Leicester), analysis of cytoskeletal function in myelination, 2008, work ongoing
Collaborator Contribution Research output
Impact NK
Start Year 2008
 
Description Life Technologies-Joydeep Guswami 
Organisation Life Technologies
Country Global 
Sector Private 
PI Contribution Joydeep Guswami
Collaborator Contribution Research output
Impact Work in progress
Start Year 2010
 
Description MRC -Development of multi-modal contrast agents for imaging and gene delivery, funding from BHF and Wellcome Trust - Carmel Moran, Keith Fox, Dave Newby, Ian Marshall, John Mullins, etc (UoE), 2005,2008. 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Development of multi-modal contrast agents for imaging and gene delivery, funding from BHF and Wellcome Trust - Carmel Moran, Keith Fox, Dave Newby, Ian Marshall, John Mullins, etc (UoE), 2005,2008.
Collaborator Contribution Research output
Impact NK
 
Description MRC funded A genetic approach to develop novel mouse models of liver disease 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Characterisation of disease models
Collaborator Contribution Several mouse models of liver disease have been established and are now being validated
Impact Mouse models will be made available to the community once validation is complete
Start Year 2008
 
Description MRC funded project to enhance axon regeneration in spinal cord injury. 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution MRC funded project to enhance axon regeneration in spinal cord injury. With Fawcett (Cambridge) Co-PI responsible for integrin engineering
Collaborator Contribution MRC funded project to enhance axon regeneration in spinal cord injury. Co-PI responsible for integrin engineering
Impact J Neurosci paper in 2009
Start Year 2008
 
Description MRC-Differentiation of hepatocytes from hES and hiPS cells Dave Hay (CRM) and Gareth Sullivan & Ian Wilmut (CRM), 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Differentiation of hepatocytes from hES and hiPS cells Dave Hay (CRM) and Gareth Sullivan & Ian Wilmut (CRM),
Collaborator Contribution several publications
Impact NK
Start Year 2009
 
Description MRC-Exocytosis in hepatocytes - Rory Duncan, Centre for Integrative Physiology, UoE 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Exocytosis in hepatocytes - Rory Duncan, Centre for Integrative Physiology, UoE
Collaborator Contribution Research output
Impact NK
Start Year 2009
 
Description MRC-Heparan sulfate in human liver and pancreas development, Cathy Merry, University of Manchester, 2010 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Heparan sulfate in human liver and pancreas development, Cathy Merry, University of Manchester, 2010
Collaborator Contribution Research output
Impact preliminary work underway
Start Year 2010
 
Description MRC-MRC clinical training fellowship (2008) for Janet Kung [CRM liver grouping]. co-supervisors Stuart Forbes (CRM) & Paddy Hadoke (CVS) 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution MRC clinical training fellowship (2008) for Janet Kung [CRM liver grouping]. co-supervisors Stuart Forbes (CRM) & Paddy Hadoke (CVS)
Collaborator Contribution Research output
Impact NK
Start Year 2009
 
Description MRC-MRC clinical training fellowship (2010) for Robert Drummond on pancreas development - P Shiels, University of Glasgow (co-supervisor), Kevin Docherty (collaborator), University of Aberdeen. [CRM liver grouping & external collaborators]. 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution MRC clinical training fellowship (2010) for Robert Drummond on pancreas development - P Shiels, University of Glasgow (co-supervisor), Kevin Docherty (collaborator), University of Aberdeen. [CRM liver grouping & external collaborators].
Collaborator Contribution Research support
Impact NK
Start Year 2009
 
Description MRC-Tissue scaffolds - Richard Black, University of Strathclyde 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Tissue scaffolds - Richard Black, University of Strathclyde
Impact application in progress
Start Year 2009
 
Description MRc-iPS creation and stem cell differentiation via small molecules - Dave Adams, Heriot-Watt,  
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution iPS creation and stem cell differentiation via small molecules - Dave Adams, Heriot-Watt, 
Collaborator Contribution Research output
Impact Prelimary work underway
Start Year 2009
 
Description McGill, Montreal, Canada-Assessing stem cell viability in 3D scaffold with FDOCT. 
Organisation McGill University
Country Canada 
Sector Academic/University 
PI Contribution Ongoing: 6 Months Ph. D. student exchange, 2010 and 2011. Assessing stem cell viability in 3D scaffold with FDOCT.
Collaborator Contribution Research output
Impact Work accepted for Photonics West, BIOS 2011, San Francisco, manuscript published in JBO (2011) Work to be presented at FSB 2012. 1st PhD visit: 2011 2nd PhD Visit from January to March 2012
Start Year 2009
 
Description Melbourne-analysis of Scribble function in meylination, 
Organisation Peter MacCallum Cancer Centre
Country Australia 
Sector Hospitals 
PI Contribution Patrick Humbert (Melbourne) analysis of Scribble function in meylination, work ongoing
Collaborator Contribution Research output
Impact Work ongoing
Start Year 2010
 
Description Milan_ analysis of neuregulin function in myelination 
Organisation San Raffaele del Monte Tabor Foundation
Country Italy 
Sector Hospitals 
PI Contribution Carla Taveggia (Milan) analysis of neuregulin function in myelination, 2008,
Collaborator Contribution research output
Impact paper in preparation
Start Year 2008
 
Description Multicell Technologies-Maertin Schroeder 
Organisation Multicell Technologies
Country United States 
Sector Private 
PI Contribution Maertin Schroeder
Collaborator Contribution Research output
Impact Work in progress
Start Year 2010
 
Description NIH funded Quantum project to develop artifical niches for stroke repair 
Organisation National Institutes of Health (NIH)
Country United States 
Sector Public 
PI Contribution NIH funded Quantum project to develop artifical niches for stroke repair With Hirschi/Dickinson/Brenner/Rice (Baylor), Price/Modo (Kings), Lovell-Badge (NIMR) Co-PI responsible for Mapping CNS stem cell niche in normal adult and following injury
Collaborator Contribution Collaborated on NIH funded Quantum project to develop artifical niches for stroke repair. Co-PI responsible for Mapping CNS stem cell niche in normal adult and following injury
Impact Paper submitted to Stem Cells
Start Year 2006
 
Description National Multiple Sclerosis Society funded translational research project funded under Promise 2010 initiative. 
Organisation Multiple Sclerosis Society
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution National Multiple Sclerosis Society funded translational research project funded under Promise 2010 initiative. With Franklin (Cambridge), Baron (Paris), Martino (Milan), Rowitch (UCSF), Goldman (Rochester), Antel (Montreal), Weiss (Calgary). Lead PI responsible for project coordination and identification of new targets for remyelination.
Collaborator Contribution National Multiple Sclerosis Society funded translational research project funded under Promise 2010 initiative. Lead PI responsible for project coordination and identification of new targets for remyelination.
Impact 2 papers in 2009 - JCB, J Neurosci.
 
Description Primorigen -Chuck Ohler 
Organisation Primorigen Biosciences
Country United States 
Sector Private 
PI Contribution Chuck Ohler
Collaborator Contribution Research output
Impact Work in progress
Start Year 2010
 
Description Role of Runx1 in differentiation of doundary cap neural crest stem cell differentiation 
Organisation Uppsala University
Department Department of Neuroscience
Country Sweden 
Sector Academic/University 
PI Contribution Provided Runx1 (short and long isoforms) inducible constructs and transgenic mice
Collaborator Contribution We learned how our Runx1 tetracyclineinducible constructs work in primary cells
Impact Publication in prestigeous stem cell magazine: Aldskogius, et al., "Regulation of Boundary Cap Neural Crest Stem Cell Differentiation after Transplantation" Stem Cells 27, 15921603
Start Year 2007
 
Description Role of Runx1 in neural development 
Organisation McGill University
Department Montreal Neurological Institute and Hospital
Country Canada 
Sector Hospitals 
PI Contribution We provided our Runx1 reactivatable knockout mouse model to Prof. S. Stifani
Collaborator Contribution We learned about the role of Runx1 in neural development which may have parallels with haematopoietic development and performed complex genotyping of compound transgenic embryos
Impact Publication in prestigeous scientific magazine PNAS: N. Stifani et al. (2008) "Suppression of interneuron programs and maintenance of selected spinal motor neuron fates by the transcription factor AML1/Runx1. Proc Natl Acad Sci USA 105, No 17, 64516456
Start Year 2006
 
Description Single vector reprogramming system 
Organisation Mount Sinai Hospital (Canada)
Department Samuel Lunenfeld Research Institute
Country Canada 
Sector Hospitals 
PI Contribution We developed a system with which we can generate non-genetically modified induced pluripotent stem cells
Collaborator Contribution By combining their piggyBac system and our single vector system we developped a system with which we can generate non-genetically modified induced pluripotent stem cells.
Impact Using the system we published two Nature papers.
Start Year 2008
 
Description Stanford-Using destabilising domain fusions to probe protein function in pluripotent cells. 
Organisation Stanford University
Country United States 
Sector Academic/University 
PI Contribution Using destabilising domain fusions to probe protein function in pluripotent cells. Supported by funding from WT & HFSP.
Collaborator Contribution Research output
Impact Grant funded; 2010-2013 HFSP Programme grant (IC, lead PI) "A microfluidic, small molecule approach to perturbation of the pluripotency transcription network." I.Chambers, T.Schroeder, T.Wandless & L.Lee. $1,200,000 US
Start Year 2007
 
Description Stem Cell Technologies-George White 
Organisation Stem Cell Technologies
Country Canada 
Sector Private 
PI Contribution George White
Collaborator Contribution Research output
Impact Work in progress
Start Year 2010
 
Description Studying transplantation of hESC-derived hepatic endoderm into animal models 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration with Philip Newsome and David Adams in studying transplantation of hESC-derived hepatic endoderm into animal models
Collaborator Contribution Collaboration in studying transplantation of hESC-derived hepatic endoderm into animal models
Impact MRC Grant awarded (£500k)
Start Year 2008
 
Description Syntaxin-basis for exocytosis blocking project in 2010, treatment for secretory disorders 
Organisation Syntaxin
Country United Kingdom 
Sector Private 
PI Contribution basis for exocytosis blocking project in 2010, treatment for secretory disorders
Collaborator Contribution NK
Impact NK
Start Year 2009
 
Description TMRI/Wyeth - completion of translational studies of biomarkers of muscle loss, large cohort study for molecular and proteomic biomarker identification in muscle loss and regeneration (sarcopenia & cancer cachexia), 
Organisation Pfizer Ltd
Department Wyeth Pharmaceuticals
Country United States 
Sector Private 
PI Contribution completion of translational studies of biomarkers of muscle loss, large cohort study for molecular and proteomic biomarker identification in muscle loss and regeneration (sarcopenia & cancer cachexia),
Collaborator Contribution Research output
Impact Publications in progress
Start Year 2009
 
Description UC, Berkeley-Bio-engineering applications for the study of pluripotent cells. 
Organisation University of California, Berkeley
Country United States 
Sector Academic/University 
PI Contribution Bio-engineering applications for the study of pluripotent cells. Supported by funding from UK FCO & HFSP.
Collaborator Contribution Research output
Impact Grants funded; 2010-2013 HFSP Programme grant (IC, lead PI) "A microfluidic, small molecule approach to perturbation of the pluripotency transcription network." I.Chambers, T.Schroeder, T.Wandless & L.Lee. $1,200,000 US & 2009 Foreign & Commonwealth Office, UK-US Stem Cell Collaboration Development Award. I.Chambers and L. Lee (UC Berkeley) £2,782
Start Year 2009
 
Description UK Multiple Sclerosis Society funded Centre for Repair in Cambridge. 
Organisation Multiple Sclerosis Society
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution UK Multiple Sclerosis Society funded Centre for Repair in Cambridge. With Franklin, Compston, Chandran, Fawcett, Spillantini (all Cambridge originally, Chandran now moved to Edinburgh) Co-PI responsible for target discovery based on array profiling remyelination and inflammation
Collaborator Contribution UK Multiple Sclerosis Society funded Centre for Repair in Cambridge. Co-PI responsible for target discovery based on array profiling remyelination and inflammation
Impact Paper submitted to Nature Neurosci (and sent out for review)
Start Year 2006
 
Description University College London-Humphrey Hodgson 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Humphrey Hodgson
Collaborator Contribution Research output
Impact Work in progress
Start Year 2010
 
Description University of Edinburgh-Analysis of the perdurance of the pluripotent state in vivo and in vitro. 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Analysis of the perdurance of the pluripotent state in vivo and in vitro. Supported by funding from WT and CONACYT (I.C.) and MRC (V.W.).
Collaborator Contribution Research output
Impact Tsakiridis, A., Tzouanacou, E.,Rahman, A., Colby, D., Axton, R., Chambers, I., Wilson, V., Forrester, L. and Brickman, J. (2009) Expression-independent gene trap vectors for random and targeted mutagenesis in embryonic stem cells. Nucleic Acids Res. 37, e129. & Osorno, R., Tsakiridis, A., Cambray, N., Economou, C., Wymeersch, F., Wilkie, R., Scotting, P., Chambers, I. and Wilson, V. The developmental extinction of pluripotency is reversed by ectopic Oct4 expression. In preparation for re-submission to Nature. I.C. & V.W. are joint senior authors.
Start Year 2007
 
Description University of Edinburgh-Bioinformatic analysis of gene expression and chromatin binding in pluripotent cells. 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Bioinformatic analysis of gene expression and chromatin binding in pluripotent cells. Supported by funding from WT and EuroSyStem.
Collaborator Contribution Researh output
Impact Paper: Chambers, I. and Tomlinson, S. (2009) The transcriptional foundation of pluripotency. Development, 136, 2311-2322, Grant submitted; MRC programme grant application "Transcription factor dynamics in control of pluripotent cell function and identity" (I. Chambers, P.I.) submitted 01/09/10; decision due Feb 2012.
Start Year 2007
 
Description University of Edinburgh-Novel gene trap vectors. 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Novel gene trap vectors. Supported by funding from WT.
Collaborator Contribution Research output
Impact Tsakiridis, A., Tzouanacou, E.,Rahman, A., Colby, D., Axton, R., Chambers, I., Wilson, V., Forrester, L. and Brickman, J. (2009) Expression-independent gene trap vectors for random and targeted mutagenesis in embryonic stem cells. Nucleic Acids Res. 37, e129.
Start Year 2009
 
Description University of Edinburgh-Structure-function investigations of Nanog and partner proteins 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Begun 2005. Structure-function investigations of Nanog and partner proteins. Supported by funding from BBSRC & WT.
Collaborator Contribution Research output
Impact Papers: Mullin, N.P., Yates, A., Rowe, A., Nijmeijer, B. Barlow, P.N., Walkinshaw, M.D. and Chambers, I. (2008) The pluripotency rheostat Nanog functions as a dimer. Biochem. J. , 411, 227-231 Cited in Faculty of 1000: http://f1000biology.com/article/id/1137963/evaluation & van den Berg, D.L.C., Snoek, T., Mullin, N.P., Yates, A., Bezstarosti, K., Demmers, J. Chambers, I. and Poot, R.A. (2010) An Oct4-centred protein interaction network in embryonic stem cells. Cell Stem Cell, 6, 369-381. Grants funded; 2008-2011 Wellcome Trust Project 'Biochemical Interactions of the Pluripotency Rheostat, Nanog'. I. Chambers, (P.I.). M. Walkinshaw & P. Barlow, £267,873 & 2005-2007 BBSRC project 'Structure-function relationship of the novel ES cell transcriptional determinant Nanog'. I. Chambers, (P.I.), M. Walkinshaw & P. Barlow, £359,327.
 
Description University of Edinburgh-analysing cell adhesion molecules in myelination 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Peter Brophy (Edinburgh), shared Wellcome Trust programme grant analysing cell adhesion molecules in myelination, 2008, work ongoing
Collaborator Contribution Research output
Impact NK
Start Year 2008
 
Description University of Edinburgh-analysis of the stem cell response in animal models of schizophrenia and bipolar disorder, 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Andrew McIntosh and David Porteus (Edinburgh), analysis of the stem cell response in animal models of schizophrenia and bipolar disorder, 2009
Collaborator Contribution Research results
Impact paper submitted to Molecular Psychiatry
Start Year 2009
 
Description University of Edinburgh-using zebrafish to examine molecular mechanisms of myelination 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution David Lyons (Edinburgh) using zebrafish to examine molecular mechanisms of myelination, 2009, paper in preparation
Collaborator Contribution Research output
Impact paper in preparation
Start Year 2009
 
Description University of Liverpool-Kevin Park 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Kevin Park
Collaborator Contribution Research output
Impact Work in progress
Start Year 2010
 
Description Unviersity of Utrecht -Jan Schrickx 
Organisation Utrecht University
Country Netherlands 
Sector Academic/University 
PI Contribution Jan Schrickx
Collaborator Contribution Research output
Impact Work in progress
Start Year 2010
 
Description Use of iPS cells to study ALS 
Organisation King's College London
Department Institute of Psychiatry, Psychology & Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution Derive iPS cells from patients with inherited cases of ALS along with age and geneder matched controls
Collaborator Contribution Tisse samples from patients and an understanding of the genetics of the disease
Impact Neural populations of different genotype for further detailed study
Start Year 2008
 
Description YK Collaboration with Edinburgh 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution NK
Collaborator Contribution Research output
Impact NK
 
Description iPerian-Mike Venuti 
Organisation Bristol-Myers Squibb
Department iPerian
Country United States 
Sector Private 
PI Contribution Mike Venuti
Collaborator Contribution Research output
Impact Work in progress
Start Year 2010
 
Description screening polymer libraries using hESC-derived hepatic endoderm 
Organisation University of Edinburgh
Department School of Chemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution screening polymer libraries using hESC-derived hepatic endoderm
Collaborator Contribution Collaboration in screening polymer libraries using hESC-derived hepatic endodermProvided library of compoounds
Impact Compounds were identified that provide effective support for human hepatic endoderm
Start Year 2008
 
Description screening polymer libraries using hESC-derived hepatic endoderm 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution screening polymer libraries using hESC-derived hepatic endoderm
Collaborator Contribution Collaboration in screening polymer libraries using hESC-derived hepatic endodermProvided library of compoounds
Impact Compounds were identified that provide effective support for human hepatic endoderm
Start Year 2008
 
Title Anterior definitive endoderm 11 
Description Anterior definitive endoderm 11 
IP Reference  
Protection Protection not required
Year Protection Granted 2008
Licensed No
Impact No subsequent impact
 
Title Apoptotic bodies for the generation of noval Abs for monoclaonal therapy 
Description Apoptotic bodies for the generation of noval Abs for monoclaonal therapy 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact No subsequent impact
 
Title CULTURE MEDIUM CONTAINING KINASE INHIBITORS, AND USES THEREOF 
Description Pluripotent cells are maintained in a self-renewing state in serum-free culture medium comprising a MEK inhibitor, a GSK3 inhibitor and, optionally, an antagonist of an FGF receptor. Pluripotent cells are also maintained in a self-renewing state in serum-free culture medium comprising a MEK inhibitor and an antagonist of an FGF receptor. Also published as EP1999249 
IP Reference US2010041137 
Protection Patent granted
Year Protection Granted 2008
Licensed No
Impact Not known
 
Title Cell Culture Methods to Produce ADE Cells 
Description Production of an efficient and effective culture method for purifying intermediate in vitro-derived ADE cells from embryonic stem cells 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact Currently available to companies
 
Title Cellular therapy to treat cirrhosis of the liver 
Description Cellular therapy to treat cirrhosis of the liver 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact No subsequent impact
 
Title Control of ES Cell Self Renewal and Lineage Specification, and Medium Therefor 
Description Self renewal of pluripotent cells in culture is promoted using a combination of an activator of a signalling pathway downstream of a receptor of the TGF-beta superfamily and an activator of a gp130 downstream signalling pathway. Also published as KR20070030164 
IP Reference JP2008228742 
Protection Patent granted
Year Protection Granted 2008
Licensed No
Impact Not known
 
Title Dextransulphate a novel reagent for stem cell differentiation 
Description Dextransulphate a novel reagent for stem cell differentiation 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact No subsequent impact
 
Title Disclosure 
Description Biodegradable Encapsulates for Affinity Targeted (BEAT) Technology in Stem Cell Culture and Regenerative Medicine 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact No subsequent impact
 
Title Disclosure 
Description Frzb role in hematopoietic differentiation 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact NK
 
Title Disclosure 
Description Glycocalyx 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact NK
 
Title Disclosure 
Description MRCT (CRB): Anti-mullerian Hormone 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact NK
 
Title Disclosure 
Description Novel Relaxin Mimetic 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact NK
 
Title Disclosure 
Description Retinoid independent and accelerated generation of functional motor neurons from human embryonic stem cells 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact NK
 
Title Disclosure 
Description Transgenic mice for studying the haemotpoetic system 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact No subsequent impact
 
Title ES Cell self renewal factor 
Description ES Cell self renewal factor 
IP Reference  
Protection Protection not required
Year Protection Granted 2008
Licensed No
Impact No subsequent impact
 
Title Embedded licence in SC4SM contract 
Description Embedded licence in SC4SM contract 
IP Reference  
Protection Protection not required
Year Protection Granted 2008
Licensed No
Impact No subsequent impact
 
Title Embedded licence: HESC Blood project 
Description Embedded licence: HESC Blood project 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact No subsequent impact
 
Title Expression of heterologous genes according to a targeted expression profile 
Description A gene trap vector comprises a DNA construct containing an expression unit of an internal ribosome binding site (IRES) coupled to a heterologous gene sequence; this expression unit is used in gene trap protocols to obtain expression of the heterologous gene in the host. 
IP Reference JP2007306942 
Protection Patent granted
Year Protection Granted 2007
Licensed No
Impact Not known
 
Title Glioma-dervided Neuronal Stem Cell Lines for Screening 
Description New method of production of glioma neural stem cell lines from tumours 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed Commercial In Confidence
Impact Discussion with commercial companies in progress
 
Title HA (800 000 D) as hESC substrate supports renewal 
Description HA (800 000 D) as hESC substrate supports renewal 
IP Reference  
Protection Protection not required
Year Protection Granted 2008
Licensed No
Impact No subsequent impact
 
Title HUMANISATION OF ANIMALS 
Description The present invention relates to the generation of transgenic animal cells and/or animals in which a large portion of a host animal's genome has been replaced with an equivalent syntenic portion of nucleic acid from the genome of a different organism. 
IP Reference EP2099289 
Protection Patent granted
Year Protection Granted 2009
Licensed No
Impact Not known
 
Title Hepatocyte differentiation media 
Description Hepatocyte differentiation media 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact No subsequent impact
 
Title High throughput method for screening gene target 
Description High throughput method for screening gene target 
IP Reference  
Protection Protection not required
Year Protection Granted 2008
Licensed No
Impact No subsequent impact
 
Title Human platelet lysates for human cartilage formation 
Description Human platelet lysates for human cartilage formation 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact No subsequent impact
 
Title Improving options for bone marrow transplants 
Description Development of a novel mehof of culture and differentiaation of embryonic stem cells that will enable derivation and exapansion of HSCs in vitro. 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact NK
 
Title Licence - tech ID 1023 - Andrew Smith 
Description Licence - tech ID 1023 - Andrew Smith - Astra Zeneca Non-exclusive 
IP Reference  
Protection Protection not required
Year Protection Granted 2008
Licensed No
Impact No subsequent impact
 
Title Licence - tech ID 1023 - Andrew Smith 
Description Licence - tech ID 1023 - Andrew Smith - Charles River Laboratories, Inc. Field Exclusive 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact NK
 
Title Licence - tech ID 1023 - Andrew Smith 
Description Licence - tech ID 1023 - Andrew Smith - Novartis AG Non-exclusive 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact No subsequent impact
 
Title Licence - tech ID 1084 - Josh Brickman 
Description Licence - tech ID 1084 - Josh Brickman - Geron Corporation Evaluation 
IP Reference  
Protection Protection not required
Year Protection Granted 2008
Licensed No
Impact No subsequent impact
 
Title Licence - tech ID 2048 - Keisuke Kaji 
Description Licence - tech ID 2048 - Keisuke Kaji - Active Motif Non Exclusive April 2010 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact NK
 
Title Licence - tech ID 2048 - Keisuke Kaji 
Description Licence - tech ID 2048 - Keisuke Kaji - Active Motif Non Exclusive Feb 2010 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact NK
 
Title Licence - tech ID 2048 - Keisuke Kaji 
Description Licence - tech ID 2048 - Keisuke Kaji - Adgene Non-exlcusive 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact No subsequent impact
 
Title Licence - tech ID 2048 - Keisuke Kaji 
Description Licence - tech ID 2048 - Keisuke Kaji - Hematech Inc Evaluation 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact No subsequent impact
 
Title Licence - tech ID 2048 - Keisuke Kaji 
Description Licence - tech ID 2048 - Keisuke Kaji - iPerian, Inc Evaluation 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact NK
 
Title Licence - tech ID 2119 - Clare Blackburn 
Description Licence - tech ID 2119 - Clare Blackburn - Millipore Corporation Non-Exclusive 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact No subsequent impact
 
Title Licence - tech ID 2127 - Josh Brickman 
Description Licence - tech ID 2127 - Josh Brickman - Stem Cells 4 Safer Medicine Limited Non-Exclusive 
IP Reference  
Protection Protection not required
Year Protection Granted 2008
Licensed No
Impact No subsequent impact
 
Title Licence - tech ID 223 & 254 - J A Ross 
Description Licence - tech ID 223 & 254 - J A Ross - Millipore Corporation Non-Exclusive 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact No subsequent impact
 
Title Licence - tech ID 223 - J A Ross 
Description Licence - tech ID 223 - J A Ross - Santa Cruz Non-Exclusive 
IP Reference  
Protection Protection not required
Year Protection Granted 2008
Licensed No
Impact No subsequent impact
 
Title Licence - tech ID 2317 - Lesley Forrester 
Description Licence - tech ID 2317 - Lesley Forrester - SNBTS Exclusive 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact No subsequent impact
 
Title Licence - tech ID 2388 - Brendon Noble 
Description Licence - tech ID 2388 - Brendon Noble - Gernon Corporation - Field Exclusive 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact NK
 
Title Licence - tech ID 254 - J A Ross 
Description Licence - tech ID 254 - J A Ross - Santa Cruz Non-exclusive 
IP Reference  
Protection Protection not required
Year Protection Granted 2008
Licensed No
Impact No subsequent impact
 
Title Licence - tech ID 928 - Keisuke Kaji 
Description Licence - tech ID 928 - Keisuke Kaji - European Collection of Cell Cultures - Non-Exclusive 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact NK
 
Title Licence under negotiation - tech ID 1084 - Josh Brickman 
Description Licence under negotiation - tech ID 1084 - Josh Brickman - evaluate use to make research reagents with view to take an exclusive licence - Evaluation 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact NK
 
Title Licence under negotiation - tech ID 2048 - Brendon Noble 
Description Licence under negotiation - tech ID 2048 - Brendon Noble - To make therapeutics - Exclusive 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact NK
 
Title Licence under negotiation - tech ID 2048 - Keisuke Kaji 
Description Licence under negotiation - tech ID 2048 - Keisuke Kaji - Company requested exclusive licence for research reagents and therapeutics. UoE thinks non-exclusive is more appropriate. Scope of licence and field of use under discussion.- Non-Exclusive 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact NK
 
Title Licence under negotiation - tech ID 2048 - Keisuke Kaji 
Description Licence under negotiation - tech ID 2048 - Keisuke Kaji - Evaluation of iPS cell lines- Non-Exclusive 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact NK
 
Title Licence under negotiation - tech ID 2048 - Keisuke Kaji 
Description Licence under negotiation - tech ID 2048 - Keisuke Kaji - Stemgent Non-Exclusive Feild of use - Research reagents 
IP Reference  
Protection Protection not required
Year Protection Granted
Licensed No
Impact No subsequent impact
 
Title Licence under negotiation - tech ID 2048 - Keisuke Kaji 
Description Licence under negotiation - tech ID 2048 - Keisuke Kaji - to humanise mouse models.- Non-Exclusive 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact NK
 
Title Licence under negotiation - tech ID 2048 - Keisuke Kaji 
Description Licence under negotiation - tech ID 2048 - Keisuke Kaji Active Motif Non-exclusive Field of use - Development of research reagents 
IP Reference  
Protection Protection not required
Year Protection Granted
Licensed No
Impact No subsequent impact
 
Title Licence under negotiation - tech ID 2048 - Keisuke Kaji 
Description Licence under negotiation - tech ID 2048 - Keisuke Kaji Mitergy LLC Evaluation licence Field of use - internal evaluation 
IP Reference  
Protection Protection not required
Year Protection Granted
Licensed No
Impact No subsequent impact
 
Title Licence under negotiation - tech ID 2048 - Keisuke Kaji 
Description Licence under negotiation - tech ID 2048 - Keisuke Kaji iPerian, Inc Evaluation licence Field of use - internal evaluation 
IP Reference  
Protection Protection not required
Year Protection Granted
Licensed No
Impact No subsequent impact
 
Title Licence under negotiation - tech ID 2198 - Mark Bradley 
Description Licence under negotiation - tech ID 2198 - Mark Bradley Stemgent Evaluation licence Field of use - in discussion 
IP Reference  
Protection Protection not required
Year Protection Granted
Licensed No
Impact No subsequent impact
 
Title Licence under negotiation - tech ID 2398 - David Hay/John Iredale 
Description Licence under negotiation - tech ID 2398 - David Hay/John Iredale - Cellartis AB - Evaluation 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact NK
 
Title Licence under negotiation - tech ID 2398 - David Hay/John Iredale 
Description Licence under negotiation - tech ID 2398 - David Hay/John Iredale - Primorigen Biosciences - Evaluation 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact NK
 
Title Lineage specific cells and progenitor cells 
Description A method for generating a culture that is purified or enriched in respect of cells of a selected lineage is described in which selectable marker, which is differentially expressed in cells of the selected lineage compared with its expression in other cells, is introduced into a multipotential cell and the multipotential cell is cultured to induce differentiation of the multipotential cell into a cell of the selected lineage, or into a mixture of cells including cells of the selected lineage, or is cultured to induce preferential survival of cells of the selected lineage. Those cells that express the selectable marker are then selected for. Progenitors of selected lineage are also described as is the use of the method in assay techniques. 
IP Reference US2007264709 
Protection Patent granted
Year Protection Granted 2009
Licensed No
Impact None known
 
Title Lithium Chloride as a novel reagent to promote stem cell differentiation into bone 
Description Lithium Chloride as a novel reagent to promote stem cell differentiation into bone 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact No subsequent impact
 
Title Method for differentiating stem cells 
Description Method for differentiating stem cells 
IP Reference  
Protection Protection not required
Year Protection Granted 2008
Licensed No
Impact No subsequent impact
 
Title Novel Polymers for culturing liver cells 
Description Identification of a novel polymer which provides a solution to poor quality cells 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed Commercial In Confidence
Impact Discussion with commercial companies in progress
 
Title Novel method for producing hepatocytes from IPS cells 
Description Novel method for producing hepatocytes from IPS cells 
IP Reference  
Protection Protection not required
Year Protection Granted 2008
Licensed No
Impact No subsequent impact
 
Title Novel method of hepatocyte differentiation form IPS cells 
Description Novel method of hepatocyte differentiation form IPS cells 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact No subsequent impact
 
Title Patent - tech ID 1084 - Josh Brickman 
Description Patent - tech ID 1084 - Josh Brickman - Endoderm Culture Type PCT 
IP Reference  
Protection Protection not required
Year Protection Granted 2008
Licensed No
Impact No subsequent impact
 
Title Patent - tech ID 1084 - Josh Brickman 
Description Patent - tech ID 1084 - Josh Brickman - Regionalised endoderm cells and uses thereof - National 
IP Reference EP2195417 
Protection Patent granted
Year Protection Granted 2010
Licensed No
Impact NK
 
Title Patent - tech ID 2048 - Keisuke Kaji 
Description Patent - tech ID 2048 - Kaji Keisuke - Induced Pluripotent Stem Cells Type - PCT 
IP Reference  
Protection Protection not required
Year Protection Granted 2008
Licensed No
Impact No subsequent impact
 
Title Patent - tech ID 2108 - Paul de Sousa 
Description Patent - tech ID 2108 - Paul de Sousa - Method for differentiating stem cells Type - National 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact No subsequent impact
 
Title Patent - tech ID 2108 - Paul de Sousa 
Description Patent - tech ID 2108 - Paul de Sousa - Method for differentiating stem cells Type - PCT 
IP Reference  
Protection Protection not required
Year Protection Granted 2008
Licensed No
Impact No subsequent impact
 
Title Patent - tech ID 2108 - Paul de Sousa 
Description Patent - tech ID 2108 - Paul de Sousa - Method for differentiating stem cells Type - Priority 
IP Reference  
Protection Protection not required
Year Protection Granted 2008
Licensed No
Impact No subsequent impact
 
Title Patent - tech ID 2110 - Paul de Sousa 
Description Patent - tech ID 2110 - Paul de Sousa - HA (800 000 D) as hESC substrate supports renenwal Type - Priority 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact No subsequent impact
 
Title Patent - tech ID 2110 - Paul de Sousa 
Description Patent - tech ID 2110 - Paul de Sousa - HA (800 000 D) as hESC substrate supports renewal Type - PCT 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact No subsequent impact
 
Title Patent - tech ID 2198 - Dave Hay/John Iredale 
Description Patent - tech ID 2198 - Dave Hay/John Iredale - Polymer for hepatocyte culture - PCT 
IP Reference WO2010106345 
Protection Patent granted
Year Protection Granted 2010
Licensed No
Impact NK
 
Title Patent - tech ID 2388 - Brendon Noble 
Description Patent - tech ID 2388 - Brendon Noble -Novel method for chondrocyte formation - Priority 
IP Reference US2011256109 
Protection Patent granted
Year Protection Granted 2011
Licensed No
Impact NK
 
Title Patent - tech ID 490 - Ian Chambers 
Description Patent - tech ID 490 - Ian Chambers - Pluripotency determining factors (Nanog) - National 
IP Reference WO2003064463 
Protection Patent granted
Year Protection Granted
Licensed No
Impact NK
 
Title Patent - tech ID 859 - Andrew Smith 
Description Patent - tech ID 859 - Andrew Smith - Genome replacement technology Type - National 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact No subsequent impact
 
Title Patent - tech ID 859 - Andrew Smith 
Description Patent - tech ID 859 - Andrew Smith - Humanisation of Animals - National 
IP Reference US20100122361 
Protection Patent granted
Year Protection Granted 2010
Licensed No
Impact NK
 
Title Plet 1 Antibodies 
Description Plet 1 Antibodies 
IP Reference  
Protection Protection not required
Year Protection Granted 2008
Licensed No
Impact No subsequent impact
 
Title Pluripotent cells from rat and other species 
Description Pluripotent cells are derived and maintained in a self-renewing state in serum-free culture medium comprising a MEK inhibitor, a GSK3 inhibitor and an antagonist of an FGF receptor. Also published as EP2049654 
IP Reference US2008066197 
Protection Patent granted
Year Protection Granted 2008
Licensed No
Impact Not known
 
Title Polymers for joint capping 
Description Polymers for joint capping 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact No subsequent impact
 
Title Primary screen to identify compounds to treat cirrhosis of the liver 
Description Primary screen to identify compounds to treat cirrhosis of the liver 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact No subsequent impact
 
Title Production of transplantable haematopoietic stem cells 
Description Production of transplantable haematopoietic stem cells 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2008
Licensed No
Impact No subsequent impact
 
Title REPROGRAMMING AND GENETIC MODIFICATION OF CELLS 
Description Methods for reprogramming and optional genetic modification of cells are provided. A pluripotent genome is obtained from a differentiated genome by fusing a pluripotent cell with a differentiated cell in the presence of Nanog or a MEK inhibitor. A cell is genetically modified by providing first and second cells, each containing chromosomes, fusing the first cell and the second cell, and culturing the fused cell so as to obtain a diploid cell containing at least one chromosome from the first cell and at least one chromosome form the second cell. A method of cell fusion comprises fusing a first cell and a second cell in the presence of Nanog or a MEK inhibitor. Cells obtained thereby and their uses are also described. 
IP Reference WO2007054720 
Protection Patent granted
Year Protection Granted 2007
Licensed No
Impact Not known
 
Title RXR agonists to promote remylination 
Description RXR agonists to promote remylination 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact No subsequent impact
 
Title Regionalised Endoderm cells and uses thereof 
Description Regionalised Endoderm cells and uses thereof 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2008
Licensed No
Impact No subsequent impact
 
Title Safely creating induced pluirpotent stem cells 
Description Development of creation of induced Pluripotent Stem Cells by introducing the apporiate genes using a non-viral plasmid -based method, which can be removed once the pluripotent cells have been generated. 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact Interest from commercial companies
 
Title Use of sonication enhancement (contrast) agents for killing bacteria 
Description Use of sonication enhancement (contrast) agents for killing bacteria James Ross 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact No subsequent impact
 
Title Using embryonic stem cells to generate red blood cells for clinical transfusion 
Description Stimulation of human embryonic stem ES cells to generate a limitless source of mature, oxygen-carrying red blood cells 
IP Reference  
Protection Protection not required
Year Protection Granted 2010
Licensed No
Impact Working with SNBTS, Unviersity of Glasgow, NHS Blood & transplant, the Irish Blood transfusion Service and Roslin Cells Ltd.
 
Description Activity 'Making PlayDoh Stem Cells' 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Primary Audience Public/other audiences
Results and Impact Activity part of the MRC Lab 'What are scientists made of, the same as you'. One of 6 stalls on making PlayDoh cells from stem cells. 15 days, total children participated in one or more activities 1,300 (MRC statistics). Organised by MRC, small contribution to development of Stem Cell activity by CRM comms officer Ingrid Heersche. Three CRM staff/studensts helped out as demonstrators at the event.

Part of a general objective of disseminating infomration concerning regenerative medicine
Year(s) Of Engagement Activity 2010
 
Description BBSRC student guide on stem cell research - May 09 - ongoing 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Primary Audience Schools
Results and Impact BBSRC is updating a booklet for secondary school students. This will be published in 2010. Scientists of the Centre (Dr Anna Williams, Dr Lesley Forrester and Dr Keisuke Kaji) have contributed a case study about their work. Post Doc Dr Nina Bauer has written part of the scientific content. Various staff have contributed to the editing process.

Remains to be seen, will be published in 2010 by the BBSRC.
Year(s) Of Engagement Activity 2009
 
Description CRM Media activity - 2008 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Media (as a channel to the public)
Results and Impact Various press releases & expert comments. Exposure in local, regional, national and international newspapers as well as TV (BBC news). Most important ones: - PubMed 18593562, Prof Alexander Medvinsky reports on a paper published in cell stem cell (July 08). - PubMed 18802003, Dr Ian Chambers reports on a paper published in Science (Nov 08). - Opening of the Centre (Nov 08). - Appointment of Dr Siddharthan Chandran (Nov 08). - MRC / UK Stem Cell Foundation / Scottish Enterprise £3.6M grant to find ways to repair bone & cartilage. Prof Brendon Noble (May 08). - Launch of Prof Charles ffrench-Constant's MS Centre with donation of JK Rowling (Apr 08), Emphasis on importance of research on MS by JK Rowling (July 08, newspapers as well as documentary on BBC 1 Scotland) - Schools Stem Cell Tour (Oct 08)

national exposure to the general public about the work done at the centre as well as showing the importance of research on stem cell & regenerative medicine.
Year(s) Of Engagement Activity 2008
 
Description CRM Media activity - 2009 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Media (as a channel to the public)
Results and Impact Various press releases & expert comments. Exposure in local, regional, national and international newspapers as well as BBC TV. Most important ones: - PubMed 19252477 and 19252478. Dr Keisuke Kaji explains about his work published in two Nature papers (March 09). - PubMed 19877180. Dr Gareth Sullivan and Prof Sir Ian Wilmut explain about the work published in Hepatology (October 09). - Collaboration between Scotland/UK and China on stem cell research and regenerative medicine (April 09). - Opening of the Euan MacDonald Centre, Prof Siddharthan Chandran (August 09). - £2.9M funding by Wellcome Trust for Prof Marc Turner on using stem cells to generate red blood cells for use in transfusions (Apr 09). - £0.4M funding by PD Society for Dr Tilo Kunath.

National exposure to the general public about the work done at the centre as well as showing the importance of research on stem cell & regenerative medicine.
Year(s) Of Engagement Activity 2009
 
Description Centre visits 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact 12 secondary school teachers for a lab-tour, documentary films and lectures. EuroStemCell comms manager Emma Kemp and researchers Tilo Kunath and Ian Chambers involved for the day.

Better equipped teachers (up to date content on stem cell research), to pass on to their secondary school students
Year(s) Of Engagement Activity 2010
 
Description Chair of organising committee 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Primary Audience Health professionals
Results and Impact Neurology Symposium at the Royal College of Physicians, Edinburgh, October 2010 - chair of organising committee. Audience - general physicians, neurologists and students from the UK. CRM Researcher Anna Williams involved.

Better informed health professionals about advances and future of regenerative medicine.
Year(s) Of Engagement Activity 2010
 
Description Contribution to hard print booklet 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Primary Audience Participants in your research and patient groups
Results and Impact Contribution to the joint Institute of Physics and EPSRC report, "Optics and photonics: Physics enhancing our lives" available as a hard print booklet and on the web http://www.iop.org/publications/iop/2009/page_38205.html. CRM researcher Pierre Bagnaninchi involved.

Book publication
Year(s) Of Engagement Activity 2009
URL http://www.iop.org/publications/iop/2009/page_38205.html
 
Description Contribution to the redevelopment of a 16+ student BBSRC booklet 'Stem Cells Science & Ethics' 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Primary Audience Schools
Results and Impact Contribution to the redevelopment of a 16+ student BBSRC booklet 'Stem Cells Science & Ethics'. Case studies from CRM researchers Anna Williams, Keisuke Kaji, Lesley Forrester. Science chapter written by CRM PostDoc Nina Bauer, edited by CRM researcher Clare Blackburn and Comms officer Ingrid Heersche. Pictures also provided.

Better understanding of basic stem cell science and ethics by 16+ secondary school students.
Year(s) Of Engagement Activity 2010
 
Description Development of teacher resources 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Development of teacher resources for secondary schools, worksheets on stem cells which can be downloaded from the EuroStemCell.org website. EuroStemCell comms manager Emma Kemp and CRM comms officer Ingrid Heersche involved.

Better equipped teachers (up to date content on stem cell research), to pass on to their secondary school students
Year(s) Of Engagement Activity 2010
 
Description Edinburgh International Science Festival - April 2008 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Primary Audience Public/other audiences
Results and Impact Dr Keisuke Kaji explained about his recently published work in Nature at the well established Science Festival in Edinburgh. He gave a presentation and participated in workshops.

Information dissemination and raising awareness.
Year(s) Of Engagement Activity 2008
 
Description Edinburgh University Stem Cell Science Course - April to June 2009 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Primary Audience Public/other audiences
Results and Impact 10 week evening course on Stem Cell Science organised by Dr Clare Blackburn, Dr Sally Lowell and Dr Tilo Kunath. Classes included lectures, discussions and seeing stem cells in the laboratory. Ten other Centre researchers (all PIs) were involved and gave lectures. There were 11 students enrolled in 2008/9. We may run this course again in 2010/11.

More knowledge on stem cell research in general as well as knowledge about the research done at the Centre.
Year(s) Of Engagement Activity 2009
 
Description Edinburgh neuroscience Christmas lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Public/other audiences
Results and Impact Edinburgh neuroscience Christmas lecture, public and interested staff, overview of regenerative medicine and stem cells December 2009. CRM researchers Charles ffrench-Constant and Siddharthan Chandran involved.

Awareness and understanding of degenerative diseases & regenerative medicine
Year(s) Of Engagement Activity 2009
 
Description EuroStemCell project 2010-2014 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Start of the 2nd EuroStemCell project 2010-2014, a large European consortium of researchers that reach out to the general public via a portal website www.eurostemcell.org, public engagement component is coordinated by CRM researcher Clare Blackburn. Outreach manager Emma Kemp and Webmanager Kate Doherty are also hosted within CRM, ongoing. The eurostemcell.org website had over 95,000 unique visitors in 2009. Development of teacher resources, films & patient information, to be translated in 9 European languages.

Awareness and understanding of stem cell research & regenerative medicine.
Year(s) Of Engagement Activity 2010
URL http://www.eurostemcell.org
 
Description Exhibit 'Stem Cells for Blood Transfusion?' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Public/other audiences
Results and Impact Development and delivery of this exhibit together with Glasgow University and Irish and Scottish Blood Transfusion Service. Researchers Marc Turner & Lesley Forrester involved as well as CRM comms officer Ingrid Heersche. In addition 12 additional demonstrators (staff & students) for actual delivery at the event. 13,000 visitors to the exhibit (49,946 total visitors to festival).

Raising awareness of stem cell applications in the future, discussing ethical issues surrounding research.
Year(s) Of Engagement Activity 2010
 
Description Family Day - 23 November 2008 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Approximately 500 people attended this event. Many of our scientists of the Centre were involved. We hosted a free Stem Cells Family Day event at Our Dynamic Earth (ODE) in Edinburgh, as a prelude to our Launch Symposium the day after. An introduction to some of the current work being undertaken in stem cell research. Events and exhibits included the following: • stem cell and life science hands-on exhibits and presentations; • a "meet the scientist" session; • the announcement of the winners of the Stem Cell school poster competition, and the display of all of the finalists' posters; • screening of the award-winning 19 minute film, "A Stem Cell Story"; • a mini-lab, giving visitors a chance to try out some of their laboratory skills, with the following tasks: o using an ultrasound scanner to identify the contents of pre-loaded boxes (a variety of shapes and figures were embedded in opaque gel); o a microscope and flasks of stem cells - embryoid bodies, cardiomyocytes and undifferentiated stem cells - giving the lab "assistants" an opportunity to see stem cells "in the flesh"; o a simulated drug screening exercise (adding weak acid to phenol red solution, which changed colour); o loading agarose gel wells with coloured dye using real lab pipettes: this was a representation of how DNA and RNA are actually analysed in the lab.

We raised awareness in the local community of Edinburgh for stem cell research and regenerative medicine in general as well for the opening of the Centre.
Year(s) Of Engagement Activity 2008
 
Description Four Inagural Lectures 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Public/other audiences
Results and Impact Four one hour lectures by Prof Charles ffrench-Constant, Prof Jim Ross, Prof Siddharthan Chandran and Prof Marc Turner

Dissemination and raising awareness at local community level on stem cells & regenerative medicine
Year(s) Of Engagement Activity 2010
 
Description ISSCR public symposium - 07 July 2009 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Primary Audience Public/other audiences
Results and Impact Approximately 150 people attended the ISSCR Public Symposium, organised at the CosmoCaixa science museum in Barcelona. The event included: - A 'Smile of a Stem Cell' photographic exhibition - Two short films: the award-winning film 'A Stem Cell Story' and a first-ever viewing of a soon-to-be-released film on iPS cells. - an audience-panel discussion with a group of stem cell scientists. It was co-organised by EuroSyStem, Dr Clare Blackburn and Ms Emma Kemp of the Centre were involved.

More knowledge and awareness for stem cell research.
Year(s) Of Engagement Activity 2009
 
Description Launch Day - 24 November 2008 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Primary Audience Participants in your research and patient groups
Results and Impact The day was organised at Our Dynamic Earth in Edinburgh. 300 invited guests from all over the world; scientific community as well as politicians and members of the MRC. The day started at 8.30am and finished at 8.00pm. After a welcome reception, the day kicked off with four scientific sessions led by our scientists Ian Wilmut, Claus Nerlov, Marc Turner, and Charles ffrench-Constant. All our PIs presented their work in a poster session, some also in separate presentations. The official launch of the Centre happened at lunchtime, the day ended with an informal networking event during a wine and canapé reception.

Raising the Centre profile in the international scientific community, the life sciences sector in Scotland as well as amongst the key politicians and policy makers in Scotland.
Year(s) Of Engagement Activity 2008
 
Description Lecture in University "Changing World" series 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Public/other audiences
Results and Impact Public lecture 'The Future of Regenerative Medicine' as part of the Unversity's "Our Changing World" series. Public: general audience, students and schoolchildren, 9 November 2010, CRM researchers Charles ffrench-Constant & Siddharthan Chandran. 120 (?) attendees.

Awareness and understanding of degenerative diseases & regenerative medicine
Year(s) Of Engagement Activity 2010
 
Description Lecture to Christians in Science 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Lecture to Christians in Sceince on stem cells 2009. Primary audience, Christians interested in science. CRM researcher Val Wilson involved.

Awareness and understanding of basic stem cell science & ethics
Year(s) Of Engagement Activity 2009
 
Description Lecture to Scottish MS Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Participants in your research and patient groups
Results and Impact Invited lecture to Scottish MS conference Perth 2010. Overview of MS and ongoing research, health professionals and patients

Part of a general objective of disseminating infomration concerning regenerative medicine
Year(s) Of Engagement Activity 2010
 
Description Presentation at Scottish Stem Cell Network 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Primary Audience Public/other audiences
Results and Impact Public debate on the ethics of the use of embryonic stem cells

Part of a general objective of disseminating infomration concerning regenerative medicine
Year(s) Of Engagement Activity 2008
 
Description Presentation to Church group 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Description of potential uses of stem cells to derive new treatments and discussion with audience

No specific outcomes
Year(s) Of Engagement Activity 2009
 
Description Public lecture - Mexico 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Public/other audiences
Results and Impact Public lecture on stem cell banking to mark opening of stem cell facility, Guadalajara , Mexico. Physicians, members of the public. CRM researcher Josh Brickman involved.

Awareness and understanding of basic stem cell science & ethics
Year(s) Of Engagement Activity 2010
 
Description Public lecture - Sofia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Schools
Results and Impact Public lecture in Sofia, Bulgaria, [November 2009] as part of ESTOOLS 'Telescope' programme (for education of EU secondary students). CRM researcher Andrew Smith involved.

Awareness and understanding of basic stem cell science & ethics
Year(s) Of Engagement Activity 2009
 
Description Public lecture / event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Public/other audiences
Results and Impact Part of the Big Ideas Programme. 'A Stem Cell Dream: can iPS technology be used to treat Parkinson's Disease'. Evening event where public had to vote if fictional trial had to go ahead or not. CRM researchers Tilo Kunath, Ian Wilmut and Siddharthan Chandran involved. Organised by Ingrid Heersche, chaired by BBC journalist Eleanor Bradford. 91 attendees, 14 April 2010.

Part of a general objective of disseminating infomration concerning regenerative medicine
Year(s) Of Engagement Activity 2010
 
Description Public meeting at a church 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Public/other audiences
Results and Impact Public meeting at a church for 50 people, including showing the films 'A Stem Cell Story' and 'Ethics, Science and Stem Cells' as well as a lively discussion. EuroStemCell comms manager Emma Kemp and CRM researcher Clare Blackburn involved.

Part of a general objective of disseminating infomration concerning regenerative medicine
Year(s) Of Engagement Activity 2010
 
Description Response to patient enquiries - 2009 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Participants in your research and patient groups
Results and Impact The Centre receives approximately 60 - 80 patient enquiries per year. Patients are looking general information on stem cell research, information about stem cell trials and clinics, and medical advice about their treatment. Due to the sensitive and specific nature of these enquiries, they are always dealt with on an individual basis by the Centre's scientific communication officer or, occasionally, by the Centre's researchers.

More knowledge on stem cell research in general. The Centre has adopted a policy not to give advice regarding a specific stem cell treatment or clinical trial.
Year(s) Of Engagement Activity 2009
 
Description Response to patient enquiries - 2010 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact CRM receives approximately 60 - 80 patient enquiries per year that are always dealt with on an individual basis due to the sensitive and specific nature of these enquiries; we also answer approx 20 student queries per year. CRM comms officer Ingrid Heersche involved.

Better informed patients & relatives about advances and future of regenerative medicine.
Year(s) Of Engagement Activity 2009,2010
 
Description School Stem Cell Poster Competition - November 2008 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact The Stem Cell Poster Competition 2008 3 schools entered the poster competition. 2 teams from each school (S2 and senior) entered a poster. The work of the finalists and winners of was on display at the Family Day, the Launch Symposium and the Royal Society of Edinburgh's discussion forum: "Regenerative Medicine: how will it change my life?" Each S2 and senior team consisted of between two and four students, with a supervising teacher. The teams provided content and initial artwork, while the graphics and printing facilities of the University were used to realise the final posters.

Engaged awareness in schools about Stem Cell Research that goes on at the Centre.
Year(s) Of Engagement Activity 2008
 
Description School visit - 16/17 November 2009 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact Two day workshop at a local school (Liberton High School), involving 60 kids and 3 teachers (as part of a collaborative European project). Six Centre students and staff involved, including Dr Tilo Kunath. Part of the workshop was exchanging ideas with another European school.

More knowledge on stem cell research in general, encouraging future scientists to work in the area of regenerative medicine, exposure for the Centre.
Year(s) Of Engagement Activity 2009
 
Description School visits 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Schools
Results and Impact Development of a stem cell lesson for use by educators as part of the EuroSyStem and EuroStemCell project. Piloted at 3 schools (368 students in total). Development done by of EuroSyStem / EuroStemCell outreach manager Emma Kemp with one CRM researcher Ian Chambers. To be finalised in 2011. Schools included Tynecastle High School (Edinburgh) and The Derby School (Lancashire)

Awareness and understanding of basic stem cell science & ethics
Year(s) Of Engagement Activity 2010
 
Description Schools Tour September - September / October 2008 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact The activity was organised together with The University of Edinburgh's SCI-Fun team. 8 local secondary schools were visited: •Peebles HS (Scottish Borders) •St George's School (Edin) •Tynecastle HS (Edin) •Newbattle CHS (Midlothian) •Preston Lodge HS (East Lothian) •Liberton HS (Edin) •St Margaret's Ac (West Lothian) •Queensferry HS (Edin) It was a morning or afternoon programme for the whole year group (S1 or S2, school decided) that consisted of: -two presentations (a stem cell show and a senses show) -a hands-on exhibit -a career show -a meet-the-scientist session (of the Centre) Total number of S1 / S2 students 1136 Total number of senior students 245 Total number of teachers 60

Engaged schools in the research that goes on at the Centre.
Year(s) Of Engagement Activity 2008
 
Description Stem Cell Roadshow 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Primary Audience Schools
Results and Impact Set up of SSCN Stem Cell Roadshow to secondary school pupils in Scotland as well as delivery of one of the events. 4 schools, 100 pupils in total. Researcher Dave Hay involved.

Raising awareness of stem cell applications in the future, discussing ethical issues surrounding research.
Year(s) Of Engagement Activity 2010
 
Description TickTock Media Ltd student guide on stem cell research - Sept 09 - ongoing 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact TickTock MEDIA LTD, a publisher of educational materials, are producing a booklet for secondary school students on Stem Cell Technology. This will be published in 2010. Professor Sir Ian Wilmut has contributed a case study about his work. Various staff have contributed to the editing process.

Remains to be seen, will be published in 2010.
Year(s) Of Engagement Activity 2009
 
Description Various press releases & expert comments 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Primary Audience Media (as a channel to the public)
Results and Impact Various press releases & expert comments with exposure in local, regional, national and international newspapers as well as TV (STV news).

Part of a general objective of disseminating infomration concerning regenerative medicine
Year(s) Of Engagement Activity 2010
 
Description Visits / talks / written interviews for patient groups 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Participants in your research and patient groups
Results and Impact Several lectures to patient groups by several researchers, total number of patients involved approx 100 (MS branches in Perth and Irvine; Leukaemia and Lymphoma Research Scotland, Parkinson's UK). Researchers Charles ffrench-Constant, Anna Williams, Tilo Kunath and Clare Blackburn involved.

Better informed patients & relatives about advances and future of regenerative medicine
Year(s) Of Engagement Activity 2010
 
Description Visits / talks / written interviews for patient groups - 2009 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Primary Audience Participants in your research and patient groups
Results and Impact Various visits and talks to patient groups, including: - Dr Anna Williams hosted a stem cell workshop at MS Myspace conference for MS patients and their families in Perth. - Dr Anna Williams gave a lecture and Q&A meeting at Craighall MS Community Group. - Following a donation of £10k for the Kinross branch of the MS Society Dr Anna Williams hosted a visit of the group at the Centre. - Dr Tilo Kunath has had visits from various individual Parkinsons patients. - Dr Tilo Kunath hosted a visit at the Centre for the PD Society's branch Edinburgh Young Parkinson's. - Several interviews in (local) patient group magazines, including MS Society and PD Society.

dissemination and raising awareness at local community level as well as national level.
Year(s) Of Engagement Activity 2008
 
Description Visits / talks/ written inteviews for patient groups - 2008 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Primary Audience Participants in your research and patient groups
Results and Impact Various visits and talks to patient groups, including: - MS Life lecture 2008 (Glasgow) - a meeting of the MS Society for patients and families - Hosted a visit by our principal donor JK Rowling.

dissemination and raising awareness at local community level as well as national level.
Year(s) Of Engagement Activity 2008
 
Description Visits for students and secondary school children - 2009 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact Various activities, including: - An afternoon programme for 20 American exchange students, involving two lectures by Prof Sir Ian Wilmut and Prof Stuart Forbes as well as a lab tour (Oct 09). - A visit from 3 secondary school students from a local school. Hosted by Dr Tilo Kunath and Dr Keisuke Kaji.

More knowledge on stem cell research in general, encouraging future scientists to work in the area of regenerative medicine, exposure for the Centre.
Year(s) Of Engagement Activity 2009
 
Description Workshop on stem cells & resources 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Primary Audience Schools
Results and Impact Workshop on stem cells & resources for secondary school teachers as part of the annual ASE conference, 16 participants. EuroStemCell comms manager Emma Kemp and CRM comms officer Ingrid Heersche involved.

Better equipped teachers (up to date content on stem cell research), to pass on to their secondary school students
Year(s) Of Engagement Activity 2010
 
Description X-mas lecture at University of Edinburgh - 04 December 2009 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Primary Audience Public/other audiences
Results and Impact Prof Charles ffrench-Constant and Prof Siddharthan Chandran on 'Stem Cells for Neurological Disorders - where now' (Dec 09). Approx 300 people attended this lecture, which was followed by a short Q&A session and a drink. Available online: http://www.edinburghneuroscience.ed.ac.uk/christmaslecture/2009/

More knowledge on stem cell research in general as well as exposure for all the Centres involved (CRM, MS Centre, Euan MacDonald Centre).
Year(s) Of Engagement Activity 2009