Epidemiological and statistical research on health problems of developing countries: MRC Tropical Epidemiology Group
Lead Research Organisation:
London Sch of Hygiene and Trop Medicine
Department Name: Epidemiology and Population Health
Abstract
While there have been major improvements over the past century in the health of populations all over the world, there are still deep inequalities between the rich and poor nations. Gains in health in many of the poor countries have been reversed recently due to the global epidemic of HIV/AIDS and steep increases in TB and malaria. Life expectancy in some parts of Africa has fallen by more than 20 years. There is an urgent need to find effective means of controlling these major killer diseases in order to bring down the high burden of mortality and ill health.
The MRC Tropical Epidemiology Group is a group based at the London School of Hygiene and Tropical Medicine whose main aim is to conduct research on these infectious diseases in Africa and other parts of the developing world. We collaborate with scientific groups overseas, assisting especially with the planning and analysis of research studies. These studies are designed to improve our understanding of risk factors for these diseases, and to evaluate the impact of different control measures.
During the next five years, our main focus will be on HIV, TB and malaria which between them cause around eight million deaths each year. We will study various ways of preventing HIV infection, as well as approaches to providing treatment for HIV-positive people in Africa where health-care resources are limited. Because the risk of TB is increased by HIV infection, TB is now out of control in some countries with major HIV epidemics, and we will therefore study new ways of preventing and treating TB. In malaria, our research will focus on intermittent preventive treatment, a new approach whereby all children and pregnant women are given periodic doses of antimalarial treatment, and on improved methods of controlling the mosquitoes that transmit malaria. We will also carry out work to develop new methods that can be used to study these health problems in developing countries.
As well as reporting our work in scientific journals, we frequently write articles aimed at a non-specialist audience, as well as contributing to television and radio programmes.
The MRC Tropical Epidemiology Group is a group based at the London School of Hygiene and Tropical Medicine whose main aim is to conduct research on these infectious diseases in Africa and other parts of the developing world. We collaborate with scientific groups overseas, assisting especially with the planning and analysis of research studies. These studies are designed to improve our understanding of risk factors for these diseases, and to evaluate the impact of different control measures.
During the next five years, our main focus will be on HIV, TB and malaria which between them cause around eight million deaths each year. We will study various ways of preventing HIV infection, as well as approaches to providing treatment for HIV-positive people in Africa where health-care resources are limited. Because the risk of TB is increased by HIV infection, TB is now out of control in some countries with major HIV epidemics, and we will therefore study new ways of preventing and treating TB. In malaria, our research will focus on intermittent preventive treatment, a new approach whereby all children and pregnant women are given periodic doses of antimalarial treatment, and on improved methods of controlling the mosquitoes that transmit malaria. We will also carry out work to develop new methods that can be used to study these health problems in developing countries.
As well as reporting our work in scientific journals, we frequently write articles aimed at a non-specialist audience, as well as contributing to television and radio programmes.
Technical Summary
The MRC Tropical Epidemiology Group initiates and collaborates in research on the epidemiology and control of public health problems of developing countries. We provide statistical and epidemiological support for the MRC Units in Uganda and The Gambia while also collaborating with other groups carrying out high-quality research overseas. We carry out observational and experimental studies, but the main emphasis is on intervention studies, including cluster-randomised trials (CRTs) in which we have special expertise. We have major programmes of work on HIV and other sexually transmitted infections (STIs), tuberculosis (TB) and malaria, but also carry out research on other diseases of public health importance.
In HIV/STI research, we will complete trials of adolescent sexual health interventions and of the Pro-2000 vaginal microbicide, continue our work on herpes control for HIV prevention, and develop research on the implementation of male circumcision services. A trial of home-based antiretroviral treatment (ART) will be completed and new research conducted on adherence, drug resistance, and different models of ART provision. Work on human papilloma virus (HPV) will include a bridging study of HPV vaccine and seroepidemiological studies to guide vaccination policy. In TB research, we will continue to collaborate with the CREATE consortium and three CRTs of TB control interventions in HIV-endemic populations will be completed, as will a trial of a four-month TB treatment regimen. Malaria research will focus on trials of different strategies of intermittent preventive therapy (IPT) in children and pregnant women, with special emphasis on IPT regimens in areas of seasonal transmission. We will collaborate in trials of two malaria vaccine candidates and research on the effectiveness of improved methods of vector control. Research on acute respiratory infections will focus on population-level effects of vaccination programmes. We will expand our work on mental health, with trials of interventions against common mental disorders and alcohol misuse.
Mathematical modelling work will include studies of HIV transmission in adolescents, and the evolving HIV epidemic in Uganda; studies aimed at interpreting the CRTs of TB control interventions; and research to explore the effects of household clustering on trachoma control. Methodological work will be carried out on the analysis of CRTs, analytical methods for zero-inflated data and highly skewed endpoints such as viral loads and parasite counts, and implementation of GCP procedures in resource-poor settings. We will support the development of the new MRC-supported Intervention Trials Unit in Mwanza and strengthen our programme of TEG training fellowships.
In HIV/STI research, we will complete trials of adolescent sexual health interventions and of the Pro-2000 vaginal microbicide, continue our work on herpes control for HIV prevention, and develop research on the implementation of male circumcision services. A trial of home-based antiretroviral treatment (ART) will be completed and new research conducted on adherence, drug resistance, and different models of ART provision. Work on human papilloma virus (HPV) will include a bridging study of HPV vaccine and seroepidemiological studies to guide vaccination policy. In TB research, we will continue to collaborate with the CREATE consortium and three CRTs of TB control interventions in HIV-endemic populations will be completed, as will a trial of a four-month TB treatment regimen. Malaria research will focus on trials of different strategies of intermittent preventive therapy (IPT) in children and pregnant women, with special emphasis on IPT regimens in areas of seasonal transmission. We will collaborate in trials of two malaria vaccine candidates and research on the effectiveness of improved methods of vector control. Research on acute respiratory infections will focus on population-level effects of vaccination programmes. We will expand our work on mental health, with trials of interventions against common mental disorders and alcohol misuse.
Mathematical modelling work will include studies of HIV transmission in adolescents, and the evolving HIV epidemic in Uganda; studies aimed at interpreting the CRTs of TB control interventions; and research to explore the effects of household clustering on trachoma control. Methodological work will be carried out on the analysis of CRTs, analytical methods for zero-inflated data and highly skewed endpoints such as viral loads and parasite counts, and implementation of GCP procedures in resource-poor settings. We will support the development of the new MRC-supported Intervention Trials Unit in Mwanza and strengthen our programme of TEG training fellowships.
Organisations
- London Sch of Hygiene and Trop Medicine, United Kingdom (Lead Research Organisation)
- UNICEF, United States (Collaboration)
- Georgia Institute of Technology, United States (Collaboration)
- Harare City Health Department (Collaboration)
- Foundation for Professional Development (Collaboration)
- University of Namibia (Collaboration)
- Government of Mozambique (Collaboration)
- Amhara National Regional State (Collaboration)
- University of Yaoundé (Collaboration)
- Merlin, Afghanistan (Collaboration)
- University of Nigeria (Collaboration)
- Sudan's National Malaria Prevention and Control Program (NMCP) (Collaboration)
- University Teaching Hospital Zambia (Collaboration)
- Save the Children, United Kingdom (Collaboration)
- The AIDS Support Organization (TASO) (Collaboration)
- University of Oxford, United Kingdom (Collaboration)
- National Institute for Medical Research (Collaboration)
- Government of South Africa (Collaboration)
- HealthNet (Collaboration)
- World Health Organization (WHO) (Collaboration)
- Paris Descartes University, France (Collaboration)
- University of Texas at San Antonio, United States (Collaboration)
- National Institutes of Health, United States (Collaboration)
- Makerere University, Uganda (Collaboration)
- Ministry of Health and Child Welfare of the Republic of Zimbabwe (Collaboration)
- Ministry of Health, Uganda (Collaboration)
- University College London, United Kingdom (Collaboration)
- Government of China (Collaboration)
- Institute of Tropical Medicine (Collaboration)
- National Health Laboratory Services, South Africa (Collaboration)
- Christian Medical College Vellore (Collaboration)
- Aga Khan University (Collaboration)
- The National Malaria Control Programme of Benin (Collaboration)
- Government of Equatorial Guinea (Collaboration)
- Makerere University College of Health Sciences (Collaboration)
- Zimbabwe Population Services International (PSI) (Collaboration)
- University of Hong Kong, Hong Kong (Collaboration)
- Norwegian University of Life Sciences (NMBU) (Collaboration)
- Durham University, Durham (Collaboration)
- University of California, San Francisco, United States (Collaboration)
- Drugs for Neglected Diseases initiative (DNDi) (Collaboration)
- Imperial College London, United Kingdom (Collaboration)
- World Bank Group (Collaboration)
- University of Bamako (Collaboration)
- Worldwide Antimalarial Resistance Network (Collaboration)
- Institute of Development Research (IRD) (Collaboration)
- University of the Witwatersrand, South Africa (Collaboration)
- Johns Hopkins University, United States (Collaboration)
- Ministry of Health and Social Welfare (Collaboration)
- Universite Montpellier (Collaboration)
- University of California, Berkeley (Collaboration)
- University of Nairobi, Kenya (Collaboration)
- Medical Care Development International (MCDI) (Collaboration)
- Zanzibar Malaria Control Program (Collaboration)
- National University of Singapore, Singapore (Collaboration)
- University of Cape Town (Collaboration)
- Zambia AIDS Related Tuberculosis (Collaboration)
- University of Malawi, Malawi (Collaboration)
- Kintampo Health Research Centre (Collaboration)
- National Centre for Research and Training on Malaria (Collaboration)
- Ifakara Health Institute, Tanzania, United Republic of (Collaboration)
- Ghana Health Service (Collaboration)
- Voluntary Health Association of Goa (Collaboration)
- Centers for Disease Control and Prevention (CDC) (Collaboration)
- Entebbe District Hospital (Collaboration)
- National Malaria Control Programme, Cambodia (Collaboration)
- Health Protection and Research Organisation (HPRO) (Collaboration)
- Cameroon National Malaria Control Programme (Collaboration)
- Yale University (Collaboration)
- University of East London (Collaboration)
- Aix-Marseille University, France (Collaboration)
- University of Copenhagen, Denmark (Collaboration)
- Kilimanjaro Christian Medical Centre (KCMS) (Collaboration)
- Wellcome Trust, LONDON (Collaboration)
- Moorfields Eye Hospital NHS Foundation Trust, London (Collaboration)
- University of Ouagadougou (Collaboration)
- National Malaria Control Programme, Namibia (Collaboration)
- Aurum Institute (Collaboration)
- University Cheikh Anta Diop de Dakar (Collaboration)
- United Nations (UN) (Collaboration)
- Addis Ababa University, Ethiopia (Collaboration)
- National Malaria Control Programme (NMCP) (Collaboration)
- Jhpiego (Collaboration)
- Centre for Sexual Health and HIV AIDS Research Zimbabwe (CeSHHAR Zimbabwe) (Collaboration)
- El Bosque University (Collaboration)
- MRC/UVRI Uganda Research Unit on AIDS, Uganda (Collaboration)
- Xinjiang Medical University (Collaboration)
- Roll Back Malaria (Collaboration)
- Joint United Nations Programme on HIV/AIDS (UNAIDS) (Collaboration)
- Carter Centre (Collaboration)
- Muhimbili Wellcome Programme (Collaboration)
- Institute for Endemic Diseases IEND (Collaboration)
- Karolinska Institute, Sweden (Collaboration)
- St George's University of London, United Kingdom (Collaboration)
- Bill and Melinda Gates Foundation (Collaboration)
- Sangath (Collaboration)
- Stellenbosch University, South Africa (Collaboration)
- Medical Research Council (Collaboration)
- National Malaria Control Programme, Tanzania (Collaboration)
- University of Ilorin Teaching Hospital, Nigeria (Collaboration)
- University of Zimbabwe, Zimbabwe (Collaboration)
- Kenya National Malaria Control Programme (Collaboration)
- Kenyan Institute for Medical Research (KEMRI) (Collaboration)
- Biomedical Research and Training Inst, Zimbabwe (Collaboration)
- Liverpool School of Tropical Medicine (Collaboration)
Publications



Abu-Raddad LJ
(2013)
Have the explosive HIV epidemics in sub-Saharan Africa been driven by higher community viral load?
in AIDS (London, England)

Al-Taiar A
(2008)
Who develops severe malaria? Impact of access to healthcare, socio-economic and environmental factors on children in Yemen: a case-control study.
in Tropical medicine & international health : TM & IH

Al-Taiar A
(2009)
Socioeconomic and environmental factors important for acquiring non-severe malaria in children in Yemen: a case-control study.
in Transactions of the Royal Society of Tropical Medicine and Hygiene

Alexander N
(2011)
Design and Analysis of Vaccine Studies by HALLORAN, M. E., LONGINI JR., I. M., and STRUCHINER, C. J.
in Biometrics

Alexander N
(2011)
Multicentre prospective study on dengue classification in four South-east Asian and three Latin American countries.
in Tropical medicine & international health : TM & IH

Alexander N
(2012)
Review: analysis of parasite and other skewed counts.
in Tropical medicine & international health : TM & IH

Alexander N
(2011)
Selection and quantification of infection endpoints for trials of vaccines against intestinal helminths.
in Vaccine

Alexander N
(2011)
Can studies where subjects have different follow-up times be analysed through binomial regression?
in Memorias do Instituto Oswaldo Cruz
Title | Drama skit about menstrual experiences |
Description | A drama skit was developed to address issues around menstruation, engaging girls, boys, parents and teachers. At both of the schools participating in the study, a draft script for a play about menstruation (including strategies for managing pain, dealing with teasing from boys, transactional sex in exchange for pads, using diaries to monitor the menstrual cycle, and using a menstrual cup and re-usable pads) was supplied, and students and teachers were asked to adapt, rehearse and perform the skit at the annual parents' day. |
Type Of Art | Performance (Music, Dance, Drama, etc) |
Year Produced | 2018 |
Impact | The final drama skit has not yet been performed but the students participating in a rehearsal reported that it has been a valuable exercise to learn about how girls can better manage their periods and that boys have a responsibility to help with this too. |
Description | Citation in policy documents: Involvement in international consultations |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Citation in other policy documents |
Impact | Participation in WHO/UNAIDS consultations on HIV prevention |
Description | Citation in policy documents: Sudanese national treatment guidelines for Visceral Leishmaniasis |
Geographic Reach | Africa |
Policy Influence Type | Citation in other policy documents |
Description | Citation in policy documents: WHO Technical Report for Control of Leishmaniases |
Geographic Reach | Africa |
Policy Influence Type | Citation in other policy documents |
Description | Citation in policy documents: WHO policy recommendation on IPTi |
Geographic Reach | Africa |
Policy Influence Type | Citation in other policy documents |
Impact | IPTi for malaria prevention in children does not impair serological repsonses to EPI vaccines |
Guideline Title | DENGUE GUIDELINES FOR DIAGNOSIS, TREATMENT, PREVENTION AND CONTROL |
Description | DENCO |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Citation in clinical guidelines |
URL | http://www.who.int/tdr/publications/documents/dengue-diagnosis.pdf |
Description | HPV Vaccination in Tanzania |
Geographic Reach | Africa |
Policy Influence Type | Citation in other policy documents |
Impact | This study of HPV vaccination delivery strategies in Tanzania assisted the Tanzanian national HPV vaccination programme to plan it's roll-out. |
Description | HSV-2 trial results |
Geographic Reach | Africa |
Policy Influence Type | Participation in a national consultation |
Impact | This was the first trial in the world to demonstrate that acyclovir had no effect on HIV incidence and the results have recently been published in the New England Journal of Medicine. The impact on policy being that this intervention would not now be seen as useful. |
Description | Health systems project on Chronic diseases in Africa |
Geographic Reach | Africa |
Policy Influence Type | Citation in other policy documents |
Description | MEMA Kwa Vijana Further Survey workshops attended by policymakers. |
Geographic Reach | Africa |
Policy Influence Type | Participation in a national consultation |
Impact | Impact on policymakers in Tanzania through their attendance at workshops. |
Description | Member of 2 external scientific advisory committees of the Innovative Vector Control Consortium (IVCC), based at Liverpool School of Tropical Medicine. |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Participation in advisory committee |
Description | Member of USAID's President's Malaria Initiative's Impact Evaluation Technical Advisory Group |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Participation in advisory committee |
Description | Member of the WHO-EMRO/UNEP sponsored Regional Scientific and Technical Advisory Committee (STAC) of the project on "Demonstration of sustainable alternatives to DDT and strengthening of vector control" |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Participation in advisory committee |
Description | Membership of guideline committee: WHO/UNAIDS Technical Consultation on Male Circumcision and HIV Prevention: Research Implications for Policy and Programming |
Geographic Reach | Africa |
Policy Influence Type | Membership of a guidance committee |
Impact | Scale of circumcision services for HIV prevention |
Description | Participation in advisory committee: Developing research agenda on HIV treatment for prevention |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Participation in advisory committee |
Impact | Funding of large-scale trials of HIV treatment for prevention |
Description | Participation in advisory committee: Pneumococcal Vaccination |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Participation in advisory committee |
Impact | Vaccination was introduced following completion of the trial |
Description | Participation in advisory committee: WHO Technical Advisory Group on Male Circumcision |
Geographic Reach | Africa |
Policy Influence Type | Participation in advisory committee |
Impact | The purpose of the group is to review information on technical innovations related to the male circumcision procedure and advise WHO on the type and quality of evidence required, further research and clinical assessments needed with a view to recommending for use in the scale-up of male circumcision for HIV prevention |
Description | SMC |
Geographic Reach | Africa |
Policy Influence Type | Citation in other policy documents |
Impact | The evidence suggests that SMC using AQ+SP monthly for up to 4 months during the transmission season in children less than 5 years of age: - Prevents approximately 75% of all malaria episodes - Prevents approximately 75% of severe malaria episodes - May result in a decrease in child mortality of around 1 in 1000 - Probably reduces the incidence of moderately severe anaemia - Does not result in an increase in clinical malaria in the following malaria transmission season after one year of administration but the consequences of giving SMC for several years have not yet been evaluated. - Serious adverse events have not been reported and are probably rare |
URL | http://www.who.int/malaria/mpac/feb2012/smc_policy_recommendation.pdf |
Description | Training of practitioners/researchers: Hib vaccine in developing countries |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | This study is widely quoted to support introduction of Hib vaccine in developing countries |
Description | Treatment of Visceral leishmaniasis - new standard regimen |
Geographic Reach | Africa |
Policy Influence Type | Citation in other policy documents |
Impact | New standard treatment regimen for affected patients in the national treatment guidelines in following countries - Sudan, Kenya, Uganda and Ethiopia. |
Description | WHO nominated member of the DDT expert group established under the Stockholm Convention on Persistent Organic Pollutants |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Participation in advisory committee |
Description | Zamstar: Citation in WHO guidelines on active case-finding for TB |
Geographic Reach | Africa |
Policy Influence Type | Membership of a guidance committee |
Description | Zamstar: Influence on policy and practice in South Africa for provision of TB and HIV diagnosis and linkage to care in the households of TB cases |
Geographic Reach | Africa |
Policy Influence Type | Participation in a national consultation |
Description | EDCTP: Call for the support of clinical trials, capacity building and networking on treatment of HIV/AIDS |
Amount | £267,222 (GBP) |
Organisation | Sixth Framework Programme (FP6) |
Department | European and Developing Countries Clinical Trials Partnership |
Sector | Public |
Country | Netherlands |
Start | 12/2010 |
End | 01/2015 |
Description | EDCTP: Call for the support of clinical trials, capacity building and networking on treatment of HIV/AIDS |
Amount | £474,902 (GBP) |
Organisation | Sixth Framework Programme (FP6) |
Department | European and Developing Countries Clinical Trials Partnership |
Sector | Public |
Country | Netherlands |
Start | 03/2011 |
End | 03/2015 |
Description | EDCTP: Site preparation & capacity strengthening trials of vaginal mirobicides |
Amount | £1,784,522 (GBP) |
Organisation | Sixth Framework Programme (FP6) |
Department | European and Developing Countries Clinical Trials Partnership |
Sector | Public |
Country | Netherlands |
Start | 05/2007 |
End | 12/2011 |
Description | EU FP7 Theme: Low-cost interventions for disease control in resource poor settings |
Amount | £316,216 (GBP) |
Organisation | European Commission |
Department | Seventh Framework Programme (FP7) |
Sector | Public |
Country | European Union (EU) |
Start | 01/2013 |
End | 12/2015 |
Description | Joint Global Health Trials Development Grant |
Amount | £200,000 (GBP) |
Funding ID | MR/P020283/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2017 |
End | 10/2018 |
Description | NIH-HPTN: Call for Proposals for HIV Combination Prevention |
Amount | £24,000,000 (GBP) |
Organisation | National Institutes of Health (NIH) |
Sector | Public |
Country | United States |
Start | 01/2011 |
End | 12/2016 |
Description | Wellcome Trust: Epidemiology of HIV infection among adolscents in Africa |
Amount | £311,400 (GBP) |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Title | Methodological Research Papers |
Description | Research papers developing methodological approaches and techniques in the field of tropical epidemiology |
Type Of Material | Data analysis technique |
Provided To Others? | No |
Impact | Adoption of new / revised methodological approaches within the discipline |
Title | Vaginal Practice Pictoral Diary |
Description | Pictorial data collection tool in which participants record their vaginal practice and sexual history daily. |
Type Of Material | Data analysis technique |
Provided To Others? | No |
Impact | Submitted paper to Sexually Transmitted Diseases "Vaginal practices diary: development of a pictorial data collection tool for sensitive behavioural data" |
Description | A randomised trial of home-based versus facility-based HIV care in Jinja, Uganda |
Organisation | MRC/UVRI Uganda Research Unit on AIDS |
Country | Uganda |
Sector | Public |
PI Contribution | Writing the proposal and securing funding |
Collaborator Contribution | Implementation, coordination and management of trial |
Impact | This trial is the largest study of task shifting and of community delivery of HIV care conducted in Africa. The findings were used by the World Health Organisation to inform part of the new guidelines on the treatment of HIV-infection. |
Start Year | 2008 |
Description | A randomised trial of home-based versus facility-based HIV care in Jinja, Uganda |
Organisation | The AIDS Support Organization (TASO) |
Country | Uganda |
Sector | Charity/Non Profit |
PI Contribution | Writing the proposal and securing funding |
Collaborator Contribution | Implementation, coordination and management of trial |
Impact | This trial is the largest study of task shifting and of community delivery of HIV care conducted in Africa. The findings were used by the World Health Organisation to inform part of the new guidelines on the treatment of HIV-infection. |
Start Year | 2008 |
Description | Analysis and reporting of Tanzania national HIV care and treatment data |
Organisation | Kilimanjaro Christian Medical Centre (KCMS) |
Country | Tanzania, United Republic of |
Sector | Hospitals |
PI Contribution | Conduct of statistical analyses, report production and development of publications |
Collaborator Contribution | Conduct of workshops, collation of data and writing up of results |
Impact | Kilama B, Todd J, Ewings F, Nondi J, Sambu V, Kisendi R, Josiah R, Ramadhani A, Mmbando D. Tanzanian experience: Treatment outcomes after 7 years of a national public-driven HIV care and treatment program. Int AIDS Soc. Malaysia (TULBPE39); 2013. |
Start Year | 2012 |
Description | Analysis and reporting of Tanzania national HIV care and treatment data |
Organisation | Ministry of Health and Social Welfare |
Country | Tanzania, United Republic of |
Sector | Public |
PI Contribution | Conduct of statistical analyses, report production and development of publications |
Collaborator Contribution | Conduct of workshops, collation of data and writing up of results |
Impact | Kilama B, Todd J, Ewings F, Nondi J, Sambu V, Kisendi R, Josiah R, Ramadhani A, Mmbando D. Tanzanian experience: Treatment outcomes after 7 years of a national public-driven HIV care and treatment program. Int AIDS Soc. Malaysia (TULBPE39); 2013. |
Start Year | 2012 |
Description | Capacity Development |
Organisation | Xinjiang Medical University |
Department | Department of Epidemiology and Biostatistics |
Country | China |
Sector | Academic/University |
PI Contribution | Training in Epidemiology |
Collaborator Contribution | Providing research data |
Impact | Training programme established between Xinjiang and LSHTM |
Start Year | 2013 |
Description | Clinical Trial: HIV combination prevention (PopArt) |
Organisation | Imperial College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Chief Investigator; Trial design; Protocol development; Trial Statistician; Supervision; Administration |
Collaborator Contribution | Trial is carried out in partnership with NIH HIV Prevention Trials Network; Trial management, laboratory activities and data management and analysis supported by HPTN Core, Network Laboratory and Data and Statistics Center; Field work coordinated at Zambart and DTTC; Modelling and economics components coordinated by Imperial College. |
Impact | Funding for trial secured, research group established, protocol version 1.0 approved, IRB submissions |
Start Year | 2011 |
Description | Clinical Trial: HIV combination prevention (PopArt) |
Organisation | National Institutes of Health (NIH) |
Department | HIV Prevention Trials Network HPTN |
Country | United States |
Sector | Charity/Non Profit |
PI Contribution | Chief Investigator; Trial design; Protocol development; Trial Statistician; Supervision; Administration |
Collaborator Contribution | Trial is carried out in partnership with NIH HIV Prevention Trials Network; Trial management, laboratory activities and data management and analysis supported by HPTN Core, Network Laboratory and Data and Statistics Center; Field work coordinated at Zambart and DTTC; Modelling and economics components coordinated by Imperial College. |
Impact | Funding for trial secured, research group established, protocol version 1.0 approved, IRB submissions |
Start Year | 2011 |
Description | Clinical Trial: HIV combination prevention (PopArt) |
Organisation | University of Stellenbosch |
Department | Desmond Tutu TB Centre |
Country | South Africa |
Sector | Academic/University |
PI Contribution | Chief Investigator; Trial design; Protocol development; Trial Statistician; Supervision; Administration |
Collaborator Contribution | Trial is carried out in partnership with NIH HIV Prevention Trials Network; Trial management, laboratory activities and data management and analysis supported by HPTN Core, Network Laboratory and Data and Statistics Center; Field work coordinated at Zambart and DTTC; Modelling and economics components coordinated by Imperial College. |
Impact | Funding for trial secured, research group established, protocol version 1.0 approved, IRB submissions |
Start Year | 2011 |
Description | Clinical Trial: HIV combination prevention (PopArt) |
Organisation | Zambia AIDS Related Tuberculosis |
Country | Zambia |
Sector | Academic/University |
PI Contribution | Chief Investigator; Trial design; Protocol development; Trial Statistician; Supervision; Administration |
Collaborator Contribution | Trial is carried out in partnership with NIH HIV Prevention Trials Network; Trial management, laboratory activities and data management and analysis supported by HPTN Core, Network Laboratory and Data and Statistics Center; Field work coordinated at Zambart and DTTC; Modelling and economics components coordinated by Imperial College. |
Impact | Funding for trial secured, research group established, protocol version 1.0 approved, IRB submissions |
Start Year | 2011 |
Description | Clinical Trial: Increasing uptake of voluntary medical male circumcision in Tanzania |
Organisation | Centers for Disease Control and Prevention (CDC) |
Country | United States |
Sector | Public |
PI Contribution | Contributing to trial design, leading statistical analysis |
Collaborator Contribution | Trial leadership, implementation of circumcision |
Impact | Ethical approval confirmed and project implementation initiated |
Start Year | 2011 |
Description | Clinical Trial: Increasing uptake of voluntary medical male circumcision in Tanzania |
Organisation | Jhpiego |
Country | United States |
Sector | Charity/Non Profit |
PI Contribution | Contributed to trial design, will lead statistical analysis |
Collaborator Contribution | Trial leadership, implementation of circumcision |
Impact | Protocol drafted |
Start Year | 2011 |
Description | Clinical Trial: Increasing uptake of voluntary medical male circumcision in Tanzania |
Organisation | National Institute for Medical Research, Tanzania |
Department | Mwanza Research Centre (MRC) |
Country | Tanzania, United Republic of |
Sector | Academic/University |
PI Contribution | Contributing to trial design, leading statistical analysis |
Collaborator Contribution | Trial leadership, implementation of circumcision |
Impact | Ethical approval confirmed and project implementation initiated |
Start Year | 2011 |
Description | Clinical Trial: Increasing uptake of voluntary medical male circumcision in Tanzania |
Organisation | National Institute for Medical Research, Tanzania |
Department | Mwanza Research Centre (MRC) |
Country | Tanzania, United Republic of |
Sector | Academic/University |
PI Contribution | Contributed to trial design, will lead statistical analysis |
Collaborator Contribution | Trial leadership, implementation of circumcision |
Impact | Protocol drafted |
Start Year | 2011 |
Description | Clinical Trial: NETSS project |
Organisation | National Centre for Research and Training on Malaria |
Country | Burkina Faso |
Sector | Public |
PI Contribution | Trial design, protocol development, statistical support |
Collaborator Contribution | Financial support |
Impact | Trial completed, showed substantial additional benefit of IPT in preventing malaria in children using insecicide treated bednets |
Start Year | 2007 |
Description | Clinical Trial: NETSS project |
Organisation | University of Bamako |
Department | Malaria Research and Training Centre (MRTC) Bamako |
Country | Mali |
Sector | Academic/University |
PI Contribution | Trial design, protocol development, statistical support |
Collaborator Contribution | Financial support |
Impact | Trial completed, showed substantial additional benefit of IPT in preventing malaria in children using insecicide treated bednets |
Start Year | 2007 |
Description | Clinical Trial: RCT to compare safety, acceptability and cost of conducting early infant male circumcision using two devices in Zimbabwe |
Organisation | Centre for Sexual Health and HIV AIDS Research Zimbabwe (CeSHHAR Zimbabwe) |
Country | Zimbabwe |
Sector | Charity/Non Profit |
PI Contribution | Contributed to trial design, will lead statistical analysis |
Collaborator Contribution | Trial leadership and all other aspects |
Impact | Protocol drafted |
Start Year | 2012 |
Description | Clinical Trial: RCT to compare safety, acceptability and cost of conducting early infant male circumcision using two devices in Zimbabwe |
Organisation | Ministry of Health and Child Welfare of the Republic of Zimbabwe |
Country | Zimbabwe |
Sector | Public |
PI Contribution | Contributed to trial design, will lead statistical analysis |
Collaborator Contribution | Trial leadership and all other aspects |
Impact | Protocol drafted |
Start Year | 2012 |
Description | Clinical Trial: RCT to compare safety, acceptability and cost of conducting early infant male circumcision using two devices in Zimbabwe |
Organisation | University College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Contributed to trial design, will lead statistical analysis |
Collaborator Contribution | Trial leadership and all other aspects |
Impact | Protocol drafted |
Start Year | 2012 |
Description | Clinical Trial: RCT to compare safety, acceptability and cost of conducting early infant male circumcision using two devices in Zimbabwe |
Organisation | University of Zimbabwe |
Country | Zimbabwe |
Sector | Academic/University |
PI Contribution | Contributed to trial design, will lead statistical analysis |
Collaborator Contribution | Trial leadership and all other aspects |
Impact | Protocol drafted |
Start Year | 2012 |
Description | Clinical Trial: RCT to compare safety, acceptability and cost of conducting early infant male circumcision using two devices in Zimbabwe |
Organisation | Zimbabwe Population Services International (PSI) |
Country | Zimbabwe |
Sector | Charity/Non Profit |
PI Contribution | Contributed to trial design, will lead statistical analysis |
Collaborator Contribution | Trial leadership and all other aspects |
Impact | Protocol drafted |
Start Year | 2012 |
Description | Clinical Trial: TB Fast Track: a cluster randomised trial to evaluate the effect of a point-of-care TB test-and-treat algorithm on early mortality in people with HIV accessing ART |
Organisation | Aurum Institute |
Country | South Africa |
Sector | Charity/Non Profit |
PI Contribution | Contributed to trial design, statistical support, data analysis |
Collaborator Contribution | Significant intellectual input and exchange of ideas |
Impact | Funding for trial secured; research group established; protocol and CRFs drafted; trial started. Recruitment to end in Dec 2014. Symposium at the Union TB conference in Barcelona 2014 on empiric TB treatment organised by TB Fast Track investigators |
Start Year | 2012 |
Description | Clinical Trial: TB Fast Track: a cluster randomised trial to evaluate the effect of a point-of-care TB test-and-treat algorithm on early mortality in people with HIV accessing ART |
Organisation | Foundation for Professional Development |
Country | South Africa |
Sector | Charity/Non Profit |
PI Contribution | Contributed to trial design, statistical support, data analysis |
Collaborator Contribution | Significant intellectual input and exchange of ideas |
Impact | Funding for trial secured; research group established; protocol and CRFs drafted; trial started. Recruitment to end in Dec 2014. Symposium at the Union TB conference in Barcelona 2014 on empiric TB treatment organised by TB Fast Track investigators |
Start Year | 2012 |
Description | Clinical Trial: TB Fast Track: a cluster randomised trial to evaluate the effect of a point-of-care TB test-and-treat algorithm on early mortality in people with HIV accessing ART |
Organisation | Johns Hopkins University |
Country | United States |
Sector | Academic/University |
PI Contribution | Contributed to trial design, statistical support, data analysis |
Collaborator Contribution | Significant intellectual input and exchange of ideas |
Impact | Funding for trial secured; research group established; protocol and CRFs drafted; trial started. Recruitment to end in Dec 2014. Symposium at the Union TB conference in Barcelona 2014 on empiric TB treatment organised by TB Fast Track investigators |
Start Year | 2012 |
Description | Clinical Trial: Treatment for visceral leischmaniasis in East Africa |
Organisation | Addis Ababa University |
Country | Ethiopia |
Sector | Academic/University |
PI Contribution | Trial design, protocol development, statistical analysis, capacity building |
Collaborator Contribution | Collaborative involvement in a number of Phase II and Phase III trials |
Impact | Funding secured and protocols finalised for one phase III trial and one phase II trial of short course treatment regimens. |
Start Year | 2012 |
Description | Clinical Trial: Treatment for visceral leischmaniasis in East Africa |
Organisation | Drugs for Neglected Diseases initiative (DNDi) |
Country | Switzerland |
Sector | Charity/Non Profit |
PI Contribution | Trial design, protocol development, statistical analysis, capacity building |
Collaborator Contribution | Collaborative involvement in a number of Phase II and Phase III trials |
Impact | Funding secured and protocols finalised for one phase III trial and one phase II trial of short course treatment regimens. |
Start Year | 2012 |
Description | Clinical Trial: Treatment for visceral leischmaniasis in East Africa |
Organisation | Institute for Endemic Diseases IEND |
Country | Sudan |
Sector | Academic/University |
PI Contribution | Trial design, protocol development, statistical analysis, capacity building |
Collaborator Contribution | Collaborative involvement in a number of Phase II and Phase III trials |
Impact | Funding secured and protocols finalised for one phase III trial and one phase II trial of short course treatment regimens. |
Start Year | 2012 |
Description | Clinical Trial: Treatment for visceral leischmaniasis in East Africa |
Organisation | Kenyan Institute for Medical Research (KEMRI) |
Country | Kenya |
Sector | Public |
PI Contribution | Trial design, protocol development, statistical analysis, capacity building |
Collaborator Contribution | Collaborative involvement in a number of Phase II and Phase III trials |
Impact | Funding secured and protocols finalised for one phase III trial and one phase II trial of short course treatment regimens. |
Start Year | 2012 |
Description | Clinical Trial: Treatment for visceral leischmaniasis in East Africa |
Organisation | Makerere University |
Country | Uganda |
Sector | Academic/University |
PI Contribution | Trial design, protocol development, statistical analysis, capacity building |
Collaborator Contribution | Collaborative involvement in a number of Phase II and Phase III trials |
Impact | Funding secured and protocols finalised for one phase III trial and one phase II trial of short course treatment regimens. |
Start Year | 2012 |
Description | Clinical Trial: cluster randomised trial of HPV vaccination delivery in schoolgirls in Mwanza |
Organisation | National Institute for Medical Research, Tanzania |
Department | Mwanza Intervention Trials Unit (MITU) |
Country | Tanzania, United Republic of |
Sector | Public |
PI Contribution | Contributed to trial design, led statistical analysis |
Collaborator Contribution | Collaborative involvement in field research; mutually reinforcing collaboration involving exchange of ideas |
Impact | Impact on national Tanzanian policy on HPV vaccination |
Start Year | 2009 |
Description | Clinical Trial: cluster randomised trial of an intensified TB/HIV prevention intervention, linking home-based HIV-testing with the option of self-testing with HIV case |
Organisation | University of Malawi |
Department | College of Medicine |
Country | Malawi |
Sector | Academic/University |
PI Contribution | Contributed to trial design, statistical support, data analysis |
Collaborator Contribution | Trial leadership and all other aspects |
Impact | Protocol finalised, baseline data collected, intervention and follow-up underway |
Start Year | 2010 |
Description | Clinical Trial: cluster randomised trial of an intensified TB/HIV prevention intervention, linking home-based HIV-testing with the option of self-testing with HIV case |
Organisation | Wellcome Trust |
Department | Malawi-Liverpool Wellcome Trust Clinical Research Programme |
Country | Malawi |
Sector | Academic/University |
PI Contribution | Contributed to trial design, statistical support, data analysis |
Collaborator Contribution | Trial leadership and all other aspects |
Impact | Protocol finalised, baseline data collected, intervention and follow-up underway |
Start Year | 2010 |
Description | Clinical Trial: cluster randomised trial of intensive versus standard anthelminthic treatment, examining effects on allergy-related and general health outcomes |
Organisation | MRC/UVRI Uganda Research Unit on AIDS |
Country | Uganda |
Sector | Public |
PI Contribution | Contributing to trial design, will lead statistical analysis |
Collaborator Contribution | Trial leadership and all other aspects |
Impact | Protocol finalised, public randomisation ceremony collected, baseline data currently being collected |
Start Year | 2011 |
Description | Clinical Trial: cluster randomised trial of using mobile text messaging and medication monitor in TB case management |
Organisation | Bill and Melinda Gates Foundation |
Country | United States |
Sector | Charity/Non Profit |
PI Contribution | Contributed to trial design, statistical support, data analysis |
Collaborator Contribution | Financial contribution; access to study cohort; exchange of ideas |
Impact | Protocol drafted & CRFs, trial completed, statistical analysis currently underway |
Start Year | 2010 |
Description | Clinical Trial: cluster randomised trial of using mobile text messaging and medication monitor in TB case management |
Organisation | Government of China |
Department | Ministry of Health of the People's Republic of China |
Country | China |
Sector | Public |
PI Contribution | Contributed to trial design, statistical support, data analysis |
Collaborator Contribution | Financial contribution; access to study cohort; exchange of ideas |
Impact | Protocol drafted & CRFs, trial completed, statistical analysis currently underway |
Start Year | 2010 |
Description | Clinical Trial: surgical treatment of trachomatous trichiasis in Ethiopia |
Organisation | Amhara National Regional State |
Country | Ethiopia |
Sector | Public |
PI Contribution | Contributed to trial design, statistical support, data analysis |
Collaborator Contribution | Significant intellectual input and exchange of ideas |
Impact | There was no evidence that absorbable polyglactin-910 sutures were associated with lower prevalence of trichiasis recurrence at 1 year postsurgery than silk sutures. However, from a programmatic perspective, polyglactin-910 offers the major advantage that patients do not have to be seen soon after surgery for suture removal |
Start Year | 2007 |
Description | Clinical Trial: surgical treatment of trachomatous trichiasis in Ethiopia |
Organisation | Carter Centre |
Country | United States |
Sector | Charity/Non Profit |
PI Contribution | Contributed to trial design, statistical support, data analysis |
Collaborator Contribution | Significant intellectual input and exchange of ideas |
Impact | There was no evidence that absorbable polyglactin-910 sutures were associated with lower prevalence of trichiasis recurrence at 1 year postsurgery than silk sutures. However, from a programmatic perspective, polyglactin-910 offers the major advantage that patients do not have to be seen soon after surgery for suture removal |
Start Year | 2007 |
Description | Clinical Trial: surgical treatment of trachomatous trichiasis in Ethiopia |
Organisation | Moorfields Eye Hospital NHS Foundation Trust |
Department | Retinal Imaging |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Contributed to trial design, statistical support, data analysis |
Collaborator Contribution | Significant intellectual input and exchange of ideas |
Impact | There was no evidence that absorbable polyglactin-910 sutures were associated with lower prevalence of trichiasis recurrence at 1 year postsurgery than silk sutures. However, from a programmatic perspective, polyglactin-910 offers the major advantage that patients do not have to be seen soon after surgery for suture removal |
Start Year | 2007 |
Description | Clinical Trial: treatment of minor trichiasis in Ethiopia |
Organisation | Amhara National Regional State |
Country | Ethiopia |
Sector | Public |
PI Contribution | Contributed to trial design, statistical support, data analysis |
Collaborator Contribution | Significant intellectual input and exchange of ideas |
Impact | Epilation had a comparable effect to surgery on visual acuity and corneal outcomes. We suggest that surgery be performed whenever possible but epilation be used for treatment of minor trichiasis patients without access to or declining surgery. Trial published in PLoS Med 2011 |
Start Year | 2007 |
Description | Clinical Trial: treatment of minor trichiasis in Ethiopia |
Organisation | Carter Centre |
Country | United States |
Sector | Charity/Non Profit |
PI Contribution | Contributed to trial design, statistical support, data analysis |
Collaborator Contribution | Significant intellectual input and exchange of ideas |
Impact | Epilation had a comparable effect to surgery on visual acuity and corneal outcomes. We suggest that surgery be performed whenever possible but epilation be used for treatment of minor trichiasis patients without access to or declining surgery. Trial published in PLoS Med 2011 |
Start Year | 2007 |
Description | Clinical Trial: treatment of minor trichiasis in Ethiopia |
Organisation | Moorfields Eye Hospital NHS Foundation Trust |
Department | NIHR Moorfields Biomedical Research Centre |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Contributed to trial design, statistical support, data analysis |
Collaborator Contribution | Significant intellectual input and exchange of ideas |
Impact | Epilation had a comparable effect to surgery on visual acuity and corneal outcomes. We suggest that surgery be performed whenever possible but epilation be used for treatment of minor trichiasis patients without access to or declining surgery. Trial published in PLoS Med 2011 |
Start Year | 2007 |
Description | Clinical trial: Azithromycin mass treatment delivery strategies for trachoma in The Gambia |
Organisation | Johns Hopkins University |
Country | United States |
Sector | Academic/University |
PI Contribution | Statistical analysis |
Collaborator Contribution | Significant intellectual input and exchange of ideas. Project leadership. |
Impact | Forty-eight communities in The Gambia were followed bi-annually for 3 years. Preparation of manuscripts is underway to report the impact of mass treatment delivery strategies on the primary trachoma outcomes, as well as secondary outcomes such as child mortality, child nutrition parameters and possible malaria co-morbidity. |
Start Year | 2008 |
Description | Clinical trial: Azithromycin mass treatment delivery strategies for trachoma in The Gambia |
Organisation | University of California |
Country | United States |
Sector | Academic/University |
PI Contribution | Statistical analysis |
Collaborator Contribution | Significant intellectual input and exchange of ideas. Project leadership. |
Impact | Forty-eight communities in The Gambia were followed bi-annually for 3 years. Preparation of manuscripts is underway to report the impact of mass treatment delivery strategies on the primary trachoma outcomes, as well as secondary outcomes such as child mortality, child nutrition parameters and possible malaria co-morbidity. |
Start Year | 2008 |
Description | Clinical trial: Community-based perinatal care in Pakistan |
Organisation | Aga Khan University |
Country | Pakistan |
Sector | Academic/University |
PI Contribution | Mutually reinforcing collaboration involving exchange of ideas |
Collaborator Contribution | Mutually reinforcing collaboration involving exchange of ideas |
Impact | The objective of this pilot study was to investigate the feasibility of delivering a package of community-based interventions for improving perinatal care using lady health workers (LHWs) and traditional birth attendants (Dais) in rural Pakistan. The study found that observed stillbirth and neonatal mortality rates improved. As such, female community health workers (i.e. LHWs and Dais) can be effective in implementing a community and outreach package that leads to improved home care practices by families, increased care-seeking behaviour and greater utilization of skilled care providers. |
Description | Clinical trial: Community-based perinatal care in Pakistan |
Organisation | World Health Organization (WHO) |
Country | Global |
Sector | Public |
PI Contribution | Mutually reinforcing collaboration involving exchange of ideas |
Collaborator Contribution | Mutually reinforcing collaboration involving exchange of ideas |
Impact | The objective of this pilot study was to investigate the feasibility of delivering a package of community-based interventions for improving perinatal care using lady health workers (LHWs) and traditional birth attendants (Dais) in rural Pakistan. The study found that observed stillbirth and neonatal mortality rates improved. As such, female community health workers (i.e. LHWs and Dais) can be effective in implementing a community and outreach package that leads to improved home care practices by families, increased care-seeking behaviour and greater utilization of skilled care providers. |
Description | Clinical trial: Comparison of home and facility-based HIV care |
Organisation | Centers for Disease Control and Prevention (CDC) |
Country | United States |
Sector | Public |
PI Contribution | Trial design; statistical input and data analysis |
Collaborator Contribution | Access to data and study cohortAccess to health care facilities |
Impact | The trial found that a home-based HIV-care strategy could improve quality of and access to HIV treatment, particularly in areas with poor infrastructure and access to clinic care. The cost of providing home-based care were marginally less than facility-based care. Findings published in Jaffar et al. Lancet, 2009;374:2080-9 |
Description | Clinical trial: Comparison of home and facility-based HIV care |
Organisation | MRC/UVRI Uganda Research Unit on AIDS |
Country | Uganda |
Sector | Public |
PI Contribution | Trial design; statistical input and data analysis |
Collaborator Contribution | Access to data and study cohortAccess to health care facilities |
Impact | The trial found that a home-based HIV-care strategy could improve quality of and access to HIV treatment, particularly in areas with poor infrastructure and access to clinic care. The cost of providing home-based care were marginally less than facility-based care. Findings published in Jaffar et al. Lancet, 2009;374:2080-9 |
Description | Clinical trial: Comparison of home and facility-based HIV care |
Organisation | Ministry of Health, Uganda |
Country | Uganda |
Sector | Public |
PI Contribution | Trial design; statistical input and data analysis |
Collaborator Contribution | Access to data and study cohortAccess to health care facilities |
Impact | The trial found that a home-based HIV-care strategy could improve quality of and access to HIV treatment, particularly in areas with poor infrastructure and access to clinic care. The cost of providing home-based care were marginally less than facility-based care. Findings published in Jaffar et al. Lancet, 2009;374:2080-9 |
Description | Clinical trial: Delivery strategies of IPT in an area of seasonal malaria transmission in the Gambia |
Organisation | Medical Research Council (MRC) |
Department | MRC Unit, The Gambia |
Country | Gambia |
Sector | Public |
PI Contribution | Trial design and statistical support for a CRT comparing delivery of intermittent preventative therapy (IPT) for malaria to older children using village health workers vs reproductive and child health trekking teams |
Collaborator Contribution | Significant intellectual input and exchange of ideas |
Impact | Trial found that delivery through village health workers achieved substantially higher coverage than reproductive and child health trekking teams. Coverage was unrelated to wealth and the cost of delivery by village health workers was half that of reproductive and child health trekking teams. Paper submitted for publication |
Start Year | 2008 |
Description | Clinical trial: Effectiveness of lay health worker led intervention for depression and anxiety in primary care |
Organisation | Sangath |
Country | India |
Sector | Charity/Non Profit |
PI Contribution | Statistical analysis and advice on trial design |
Collaborator Contribution | Significant intellectual input and exchange of ideas; access to study cohort and provision of training |
Impact | Study found that lay health counsellor led intervention comprising case management, psycho-social support and medication administered by primary care physicians resulted in a modest improvement in recovery from common mental disorders. Evidence can be used to improve mental health services in settings where mental health professionals are scarce. Results published in Patel et al; Lancet, 2010 and Patel et al; Br J Psychiatry, 2011 |
Start Year | 2008 |
Description | Clinical trial: Effectiveness of lay health worker led intervention for depression and anxiety in primary care |
Organisation | Voluntary Health Association of Goa |
Country | India |
Sector | Charity/Non Profit |
PI Contribution | Statistical analysis and advice on trial design |
Collaborator Contribution | Significant intellectual input and exchange of ideas; access to study cohort and provision of training |
Impact | Study found that lay health counsellor led intervention comprising case management, psycho-social support and medication administered by primary care physicians resulted in a modest improvement in recovery from common mental disorders. Evidence can be used to improve mental health services in settings where mental health professionals are scarce. Results published in Patel et al; Lancet, 2010 and Patel et al; Br J Psychiatry, 2011 |
Start Year | 2008 |
Description | Clinical trial: Efficacy of HSV suppressive therapy on genital and plasma HIV viral load |
Organisation | National Institute for Medical Research, Tanzania |
Country | Tanzania, United Republic of |
Sector | Public |
PI Contribution | Trial design and statistical analysis |
Collaborator Contribution | Significant intellectual input; access to study cohort and data; Mutual exchange of ideas |
Impact | The study found there was no effect of HSV suppressive therapy on either genital or plasma HIV during 30 months of follow-up which suggests that it is unlikely to be a useful long-term strategy to reduce HIV transmission. Results published in Tanton et al. Journal of Infectious Diseases, 2010; 201(9) |
Start Year | 2007 |
Description | Clinical trial: Efficacy of HSV suppressive therapy on genital and plasma HIV viral load |
Organisation | University of Paris - Descartes |
Country | France |
Sector | Academic/University |
PI Contribution | Trial design and statistical analysis |
Collaborator Contribution | Significant intellectual input; access to study cohort and data; Mutual exchange of ideas |
Impact | The study found there was no effect of HSV suppressive therapy on either genital or plasma HIV during 30 months of follow-up which suggests that it is unlikely to be a useful long-term strategy to reduce HIV transmission. Results published in Tanton et al. Journal of Infectious Diseases, 2010; 201(9) |
Start Year | 2007 |
Description | Clinical trial: Efficacy of HSV suppressive therapy on genital and plasma HIV viral load |
Organisation | Wellcome Trust |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | Trial design and statistical analysis |
Collaborator Contribution | Significant intellectual input; access to study cohort and data; Mutual exchange of ideas |
Impact | The study found there was no effect of HSV suppressive therapy on either genital or plasma HIV during 30 months of follow-up which suggests that it is unlikely to be a useful long-term strategy to reduce HIV transmission. Results published in Tanton et al. Journal of Infectious Diseases, 2010; 201(9) |
Start Year | 2007 |
Description | Clinical trial: Enhanced TB case finding in Harare, Zimbabwe |
Organisation | Aurum Institute |
Country | South Africa |
Sector | Charity/Non Profit |
PI Contribution | Designed and supported a trial comparing the effectiveness of two strategies (door-to-door and mobile van) for detecting TB in symptomatic individuals. |
Collaborator Contribution | Significant intellectual support and exchange of ideas; Access to health facilities and study cohort; Data analysis |
Impact | Trial found that mobile vans significantly out-performed door-to-door visits for detecting TB. As such, the mobile van approach could have significant and rapid effects on TB transmission and prevalence. Results published in Corbett et al. Lancet, 2010;376 |
Description | Clinical trial: Enhanced TB case finding in Harare, Zimbabwe |
Organisation | Biomedical Research and Training Institute (BRTI) |
Country | Zimbabwe |
Sector | Charity/Non Profit |
PI Contribution | Designed and supported a trial comparing the effectiveness of two strategies (door-to-door and mobile van) for detecting TB in symptomatic individuals. |
Collaborator Contribution | Significant intellectual support and exchange of ideas; Access to health facilities and study cohort; Data analysis |
Impact | Trial found that mobile vans significantly out-performed door-to-door visits for detecting TB. As such, the mobile van approach could have significant and rapid effects on TB transmission and prevalence. Results published in Corbett et al. Lancet, 2010;376 |
Description | Clinical trial: Enhanced TB case finding in Harare, Zimbabwe |
Organisation | Harare City Health Department |
Country | Zimbabwe |
Sector | Public |
PI Contribution | Designed and supported a trial comparing the effectiveness of two strategies (door-to-door and mobile van) for detecting TB in symptomatic individuals. |
Collaborator Contribution | Significant intellectual support and exchange of ideas; Access to health facilities and study cohort; Data analysis |
Impact | Trial found that mobile vans significantly out-performed door-to-door visits for detecting TB. As such, the mobile van approach could have significant and rapid effects on TB transmission and prevalence. Results published in Corbett et al. Lancet, 2010;376 |
Description | Clinical trial: Entomological approaches to malaria control |
Organisation | Durham University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Trial design, protocol development, statistical support |
Collaborator Contribution | Financial contribution |
Impact | Trials completed showing value of house screening for malaria prevention and feasibility of larval control, published in Lancet (2009) and AJTMH (2009) |
Description | Clinical trial: Entomological approaches to malaria control |
Organisation | Medical Research Council (MRC) |
Department | MRC Unit, The Gambia |
Country | Gambia |
Sector | Public |
PI Contribution | Trial design, protocol development, statistical support |
Collaborator Contribution | Financial contribution |
Impact | Trials completed showing value of house screening for malaria prevention and feasibility of larval control, published in Lancet (2009) and AJTMH (2009) |
Description | Clinical trial: HIV prevention among adolescents in Tanzania and Zimbabwe |
Organisation | Liverpool School of Tropical Medicine |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Trial design and data analysis |
Collaborator Contribution | Significant intellectual input and mutual exchange of ideas; Access to study cohort and data; Trial leadership (Zimbabwe) |
Impact | Neither trial found evidence that sexual health education coupled with improved access to reproductive health services reduced HIV incidence in adolscents. However, both trials showed increased knowledge and corresponding reductions in some risky behaviours. Findings published in Doyle et al. PLoS Med. 2010; 7(6) and Cowan et al. AIDS. 2010; 24(16) |
Description | Clinical trial: HIV prevention among adolescents in Tanzania and Zimbabwe |
Organisation | Medical Research Council (MRC) |
Country | United Kingdom |
Sector | Public |
PI Contribution | Trial design and data analysis |
Collaborator Contribution | Significant intellectual input and mutual exchange of ideas; Access to study cohort and data; Trial leadership (Zimbabwe) |
Impact | Neither trial found evidence that sexual health education coupled with improved access to reproductive health services reduced HIV incidence in adolscents. However, both trials showed increased knowledge and corresponding reductions in some risky behaviours. Findings published in Doyle et al. PLoS Med. 2010; 7(6) and Cowan et al. AIDS. 2010; 24(16) |
Description | Clinical trial: HIV prevention among adolescents in Tanzania and Zimbabwe |
Organisation | National Institute for Medical Research, Tanzania |
Department | Mwanza Intervention Trials Unit (MITU) |
Country | Tanzania, United Republic of |
Sector | Public |
PI Contribution | Trial design and data analysis |
Collaborator Contribution | Significant intellectual input and mutual exchange of ideas; Access to study cohort and data; Trial leadership (Zimbabwe) |
Impact | Neither trial found evidence that sexual health education coupled with improved access to reproductive health services reduced HIV incidence in adolscents. However, both trials showed increased knowledge and corresponding reductions in some risky behaviours. Findings published in Doyle et al. PLoS Med. 2010; 7(6) and Cowan et al. AIDS. 2010; 24(16) |
Description | Clinical trial: HIV prevention among adolescents in Tanzania and Zimbabwe |
Organisation | University College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Trial design and data analysis |
Collaborator Contribution | Significant intellectual input and mutual exchange of ideas; Access to study cohort and data; Trial leadership (Zimbabwe) |
Impact | Neither trial found evidence that sexual health education coupled with improved access to reproductive health services reduced HIV incidence in adolscents. However, both trials showed increased knowledge and corresponding reductions in some risky behaviours. Findings published in Doyle et al. PLoS Med. 2010; 7(6) and Cowan et al. AIDS. 2010; 24(16) |
Description | Clinical trial: HIV prevention among adolescents in Tanzania and Zimbabwe |
Organisation | University of Zimbabwe |
Country | Zimbabwe |
Sector | Academic/University |
PI Contribution | Trial design and data analysis |
Collaborator Contribution | Significant intellectual input and mutual exchange of ideas; Access to study cohort and data; Trial leadership (Zimbabwe) |
Impact | Neither trial found evidence that sexual health education coupled with improved access to reproductive health services reduced HIV incidence in adolscents. However, both trials showed increased knowledge and corresponding reductions in some risky behaviours. Findings published in Doyle et al. PLoS Med. 2010; 7(6) and Cowan et al. AIDS. 2010; 24(16) |
Description | Clinical trial: House screening interventions to prevent exposure to malaria in the Gambia |
Organisation | Durham University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Designed and supported a trial to assess 2 types of house screening and their impact on entry of malaria vectors and frequency of anaemia in children. |
Collaborator Contribution | Significant intellectual input and exchange of ideas; Trial leadership |
Impact | Trial found that the number of mosquitos caught in houses without screening was almost twice the number found in houses with screening. There was a corresponding reduction in anaemia. Results published in Kirby et al. Lancet 2009;374 |
Description | Clinical trial: House screening interventions to prevent exposure to malaria in the Gambia |
Organisation | Medical Research Council (MRC) |
Department | MRC Unit, The Gambia |
Country | Gambia |
Sector | Public |
PI Contribution | Designed and supported a trial to assess 2 types of house screening and their impact on entry of malaria vectors and frequency of anaemia in children. |
Collaborator Contribution | Significant intellectual input and exchange of ideas; Trial leadership |
Impact | Trial found that the number of mosquitos caught in houses without screening was almost twice the number found in houses with screening. There was a corresponding reduction in anaemia. Results published in Kirby et al. Lancet 2009;374 |
Description | Clinical trial: Impact of helminths on the response to immunisation and on incidence of infection and disease in childhood |
Organisation | Entebbe District Hospital |
Country | Uganda |
Sector | Hospitals |
PI Contribution | Designed and supported randomised trial evaluating 3 interventions at 2 stages. |
Collaborator Contribution | Trial leadership; Access to study cohort |
Impact | Trial found that anthelminthic treatment during pregnancy increased incidence of eczema in childhood, and that quarterly anthelminthic treatment during early childhood decreased the incidence of malaria. Apart from this, there were no other effects of anthelminthic treatment during pregnancy and childhood on responses to immunisations, incidence of infectious diseases, growth or anaemia. Main trial results have been published in the Lancet and in PLoS ONE. Children are now being follow-up to 10 years old. |
Start Year | 2006 |
Description | Clinical trial: Impact of helminths on the response to immunisation and on incidence of infection and disease in childhood |
Organisation | MRC/UVRI Uganda Research Unit on AIDS |
Country | Uganda |
Sector | Public |
PI Contribution | Designed and supported randomised trial evaluating 3 interventions at 2 stages. |
Collaborator Contribution | Trial leadership; Access to study cohort |
Impact | Trial found that anthelminthic treatment during pregnancy increased incidence of eczema in childhood, and that quarterly anthelminthic treatment during early childhood decreased the incidence of malaria. Apart from this, there were no other effects of anthelminthic treatment during pregnancy and childhood on responses to immunisations, incidence of infectious diseases, growth or anaemia. Main trial results have been published in the Lancet and in PLoS ONE. Children are now being follow-up to 10 years old. |
Start Year | 2006 |
Description | Clinical trial: Implementation and evaluation of an optimized model for scaling up TB/HIV integration at primary care clinics in Ekurhuleni north sub-district, South Africa |
Organisation | Aurum Institute |
Country | South Africa |
Sector | Charity/Non Profit |
PI Contribution | Contributed to trial design, statistical support, data analysis |
Collaborator Contribution | Significant intellectual input and exchange of ideas |
Impact | Protocol and CRFs drafted; trial completed and data currently being analysed. Paper published on trial design (Contemporary Clinical Trials 2014) |
Start Year | 2011 |
Description | Clinical trial: Microbicides Development Programme |
Organisation | Medical Research Council (MRC) |
Department | Microbicides Development Programme |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | PI for Mwanza field site; statistical input to trial |
Collaborator Contribution | Collaborative involvement in Phase III trial of Pro2000 vaginal microbicide |
Impact | Successful completion and publication of MDP301 Phase III trial; further publications in progress; capacity building in partner sites in Africa; development of proposal for MDP302 trial |
Description | Clinical trial: Micronutrient-fortified complementary foods in Lusaka |
Organisation | University Teaching Hospital |
Country | Zambia |
Sector | Hospitals |
PI Contribution | Advice on design of trial to evaluate micro-nutrient fortified porridge vs non-fortified porridge among HIV-exposed and unexposed infants aged 6 months and over. |
Collaborator Contribution | Access to study cohort and data |
Impact | Trial found that fortification improved iron status at 18 months. No significant difference was found between trial arms in terms of stunting and hospital referral but children of HIV infected mothers that breast-fed for less than 6 months displayed reduced stunting with fortified porridge. Provision of such fortified foods may benefit the health of these high risk infants. Results published in PLoS One, 2010 |
Description | Clinical trial: Treatment and prevention strategies for HIV-associated cryptococcal meningitis |
Organisation | St George's University of London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Trial design and data analysis |
Collaborator Contribution | Significant intellectual input and mutual exchange of ideas |
Impact | Findings published in several high impact journals. A second trial is now underway to determine the most effective and sustainable regimens for patients presenting with cryptococcal meningitis in resource-poor settings |
Start Year | 2006 |
Description | Clinical trial: WELL London |
Organisation | University of East London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Advice on design and analysis of cluster randomised trial |
Collaborator Contribution | Collaborative involvement in trial of wellbeing intervention in deprived areas of London |
Impact | Publication of trial design; trial completed and analysis in progress |
Start Year | 2008 |
Description | Clinical trial: Xpert MTB/RIF for diagnosis of tuberculosis: evaluating impact and cost-effectiveness in the routine roll-out in South Africa "Xpert for TB: Evaluating a New Diagnostic" (XTEND) trial and XPHACTOR study |
Organisation | Aurum Institute |
Country | South Africa |
Sector | Charity/Non Profit |
PI Contribution | Contributed to trial design, statistical support, data analysis |
Collaborator Contribution | Significant intellectual input and exchange of ideas |
Impact | Funding for trial secured; research group established; protocol and CRFs drafted; trial started. XTEND trial completed and results presented at CROI (2014) and South Africa TB conference (2014). Main paper under review and other papers in progress. XPHACTOR recruitment and follow-up completed, data currently being analysed. Interim data presented at South Africa TB (2014) and Union TB Conference (2014); Papers in progress. |
Start Year | 2011 |
Description | Clinical trial: Xpert MTB/RIF for diagnosis of tuberculosis: evaluating impact and cost-effectiveness in the routine roll-out in South Africa "Xpert for TB: Evaluating a New Diagnostic" (XTEND) trial and XPHACTOR study |
Organisation | National Health Laboratory Services, South Africa |
Country | South Africa |
Sector | Public |
PI Contribution | Contributed to trial design, statistical support, data analysis |
Collaborator Contribution | Significant intellectual input and exchange of ideas |
Impact | Funding for trial secured; research group established; protocol and CRFs drafted; trial started. XTEND trial completed and results presented at CROI (2014) and South Africa TB conference (2014). Main paper under review and other papers in progress. XPHACTOR recruitment and follow-up completed, data currently being analysed. Interim data presented at South Africa TB (2014) and Union TB Conference (2014); Papers in progress. |
Start Year | 2011 |
Description | Clinical trial: Xpert MTB/RIF for diagnosis of tuberculosis: evaluating impact and cost-effectiveness in the routine roll-out in South Africa "Xpert for TB: Evaluating a New Diagnostic" (XTEND) trial and XPHACTOR study |
Organisation | University of Cape Town |
Country | South Africa |
Sector | Academic/University |
PI Contribution | Contributed to trial design, statistical support, data analysis |
Collaborator Contribution | Significant intellectual input and exchange of ideas |
Impact | Funding for trial secured; research group established; protocol and CRFs drafted; trial started. XTEND trial completed and results presented at CROI (2014) and South Africa TB conference (2014). Main paper under review and other papers in progress. XPHACTOR recruitment and follow-up completed, data currently being analysed. Interim data presented at South Africa TB (2014) and Union TB Conference (2014); Papers in progress. |
Start Year | 2011 |
Description | Clinical trial: Xpert MTB/RIF for diagnosis of tuberculosis: evaluating impact and cost-effectiveness in the routine roll-out in South Africa "Xpert for TB: Evaluating a New Diagnostic" (XTEND) trial and XPHACTOR study |
Organisation | World Health Organization (WHO) |
Country | Global |
Sector | Public |
PI Contribution | Contributed to trial design, statistical support, data analysis |
Collaborator Contribution | Significant intellectual input and exchange of ideas |
Impact | Funding for trial secured; research group established; protocol and CRFs drafted; trial started. XTEND trial completed and results presented at CROI (2014) and South Africa TB conference (2014). Main paper under review and other papers in progress. XPHACTOR recruitment and follow-up completed, data currently being analysed. Interim data presented at South Africa TB (2014) and Union TB Conference (2014); Papers in progress. |
Start Year | 2011 |
Description | Health Platform |
Organisation | El Bosque University |
Department | Instituto de Salud y Ambiente |
Country | Colombia |
Sector | Academic/University |
PI Contribution | Design and analysis of the trial, including publications. |
Collaborator Contribution | Obtaining funding; directing and implementing the trial. |
Impact | Overgaard et al. Trials 2012, 13:182 http://www.trialsjournal.com/content/13/1/182 |
Start Year | 2010 |
Description | Health Platform |
Organisation | Norwegian University of Life Sciences (NMBU) |
Country | Norway |
Sector | Academic/University |
PI Contribution | Design and analysis of the trial, including publications. |
Collaborator Contribution | Obtaining funding; directing and implementing the trial. |
Impact | Overgaard et al. Trials 2012, 13:182 http://www.trialsjournal.com/content/13/1/182 |
Start Year | 2010 |
Description | Health systems project on chronic diseases in Africa |
Organisation | MRC/UVRI Uganda Research Unit on AIDS |
Country | Uganda |
Sector | Public |
PI Contribution | Overall PI and main applicant is TEG staff member currently based at MITU. ; study co-run by LSHTM, MITU and MoH Tanzania. TEG provides Statistical support - analysis, reporting of results. Ugandan PI based at MRC/UVRI Uganda Unit; study co-run by LSHTM, MRC Uganda and MoH Uganda. TEG provides statistical support - analysis, reporting of results. |
Collaborator Contribution | MITU: local research management. Conduct of cross-sectional surveys. MoH: collaboration on surveys; input in intervention design and supervision. MRC Uganda: local research management. Conduct of cross-sectional surveys. MoH: collaboration on surveys; input in intervention design and supervision. |
Impact | Recognition by MoH Tanzania of high burden of some NCDs and related risk factors. Several manuscripts in draft from phase 1 (surveys); planning for phase 2/3 (RCT) underway. MRC UK approved activities for phase 2. Recognition by MoH Uganda of high burden of some NCDs and related risk factors. Several manuscripts in draft from phase 1 (surveys); planning for phase 2/3 (RCT) underway. MRC UK approved activities for phase 2. |
Start Year | 2011 |
Description | Health systems project on chronic diseases in Africa |
Organisation | National Institute for Medical Research, Tanzania |
Department | Mwanza Intervention Trials Unit (MITU) |
Country | Tanzania, United Republic of |
Sector | Public |
PI Contribution | Overall PI and main applicant is TEG staff member currently based at MITU. ; study co-run by LSHTM, MITU and MoH Tanzania. TEG provides Statistical support - analysis, reporting of results. Ugandan PI based at MRC/UVRI Uganda Unit; study co-run by LSHTM, MRC Uganda and MoH Uganda. TEG provides statistical support - analysis, reporting of results. |
Collaborator Contribution | MITU: local research management. Conduct of cross-sectional surveys. MoH: collaboration on surveys; input in intervention design and supervision. MRC Uganda: local research management. Conduct of cross-sectional surveys. MoH: collaboration on surveys; input in intervention design and supervision. |
Impact | Recognition by MoH Tanzania of high burden of some NCDs and related risk factors. Several manuscripts in draft from phase 1 (surveys); planning for phase 2/3 (RCT) underway. MRC UK approved activities for phase 2. Recognition by MoH Uganda of high burden of some NCDs and related risk factors. Several manuscripts in draft from phase 1 (surveys); planning for phase 2/3 (RCT) underway. MRC UK approved activities for phase 2. |
Start Year | 2011 |
Description | Literature review: Combining indoor residual spraying and insecticide treated net interventions |
Organisation | Government of Equatorial Guinea |
Department | Ministry of Health Equatorial Guinea |
Country | Equatorial Guinea |
Sector | Public |
PI Contribution | We conducted a literature review and analysed data from Bioko and Zambezia. |
Collaborator Contribution | Significant intellectual input and exchange of ideas |
Impact | 5 of the 8 studies reviewed reported a reduced risk of infection in those communities protected by both interventions compared with one intervention alone. Surveys in Bioko and Zambezia found that spraying combined with nets resulted in a 1/3 increase in protective effect compared with IRS alone. These results justify the additional resources required for combining spraying and nets. Findings published in Kleinschmidt et al. American Journal of Tropical Medicine and Hygiene, 2009;81 |
Start Year | 2007 |
Description | Literature review: Combining indoor residual spraying and insecticide treated net interventions |
Organisation | Government of Mozambique |
Department | Ministry of Health Mozambique |
Country | Mozambique |
Sector | Public |
PI Contribution | We conducted a literature review and analysed data from Bioko and Zambezia. |
Collaborator Contribution | Significant intellectual input and exchange of ideas |
Impact | 5 of the 8 studies reviewed reported a reduced risk of infection in those communities protected by both interventions compared with one intervention alone. Surveys in Bioko and Zambezia found that spraying combined with nets resulted in a 1/3 increase in protective effect compared with IRS alone. These results justify the additional resources required for combining spraying and nets. Findings published in Kleinschmidt et al. American Journal of Tropical Medicine and Hygiene, 2009;81 |
Start Year | 2007 |
Description | Literature review: Combining indoor residual spraying and insecticide treated net interventions |
Organisation | World Health Organization (WHO) |
Department | Global Malaria Programme |
Country | Switzerland |
Sector | Charity/Non Profit |
PI Contribution | We conducted a literature review and analysed data from Bioko and Zambezia. |
Collaborator Contribution | Significant intellectual input and exchange of ideas |
Impact | 5 of the 8 studies reviewed reported a reduced risk of infection in those communities protected by both interventions compared with one intervention alone. Surveys in Bioko and Zambezia found that spraying combined with nets resulted in a 1/3 increase in protective effect compared with IRS alone. These results justify the additional resources required for combining spraying and nets. Findings published in Kleinschmidt et al. American Journal of Tropical Medicine and Hygiene, 2009;81 |
Start Year | 2007 |
Description | Malaria elimination trial |
Organisation | Aix-Marseille University |
Country | France |
Sector | Academic/University |
PI Contribution | LSHTM are responsible for the co-ordination of the trials. |
Collaborator Contribution | The University of Marseilles is contributing in terms of statistical spatial analysis, and genotyping to identify parasite strains. |
Impact | No outputs as yet to report. |
Start Year | 2013 |
Description | Mathematical modelling: Global estimates of newborn deaths by cause |
Organisation | Save the Children |
Department | Saving Newborn Lives SNL |
Country | United States |
Sector | Charity/Non Profit |
PI Contribution | Development of a statistical model to estimate the cause distribution of neonatal deaths |
Collaborator Contribution | Mutually reinforcing collaboration involving exchange of ideas |
Impact | National estimates used by WHO |
Start Year | 2007 |
Description | Modelling serotype replacement in The Gambia |
Organisation | Medical Research Council (MRC) |
Department | MRC Unit, The Gambia |
Country | Gambia |
Sector | Public |
PI Contribution | Developing a model for super-infection and simulating the impact of vaccination on pneumococcal carriage |
Collaborator Contribution | Conducting sensitivity analyses to assess whether our findings are robust to moderate levels of co-infection |
Impact | Paper published late 2013 |
Start Year | 2009 |
Description | Nonspecific effects of childhood vaccination on bacterial carriage |
Organisation | Medical Research Council (MRC) |
Department | MRC Unit, The Gambia |
Country | Gambia |
Sector | Public |
PI Contribution | Providing statistical support |
Collaborator Contribution | Assessing non-specific effects of childhood vaccines on bacterial carriage. |
Impact | Paper currently in preparation |
Start Year | 2012 |
Description | Observational Study: Rotavirus infection among Indian children living in slum areas |
Organisation | Christian Medical College, Vellore |
Country | India |
Sector | Academic/University |
PI Contribution | Statistical support, data analysis and advice on trial design. |
Collaborator Contribution | Trial leadership |
Impact | Study concluded that an urban slum population had lower natural protection from rotavirus infection because of high viral diversity, early infection and frequent reinfection giving some explanation why rotavirus vaccine may be less efficacious in Asian settings. Results published in Gladstone BP et al., 2011, Protective effect of natural rotavirus infection in an Indian birth cohort, New England Journal of Medicine, Jul 28;365(4):337-46. |
Description | Observational study: Bioko Island Malaria Control Projects, Phase I |
Organisation | Liverpool School of Tropical Medicine |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Design of monitoring and surveillance systems, annual survey design and analsysis, impact evaluation of multiple interventions |
Collaborator Contribution | Multicountry analysis of combined interventions; evaluation of surveillance methods and impact assessment; significant intellectual input and mutual exchange of ideas |
Impact | Phase I found a major reduction in child mortality following an intensification of malaria control initiatives over a 4 year period on Bioko Island, Equatorial Guinea. Results published in Kleinschmidt et al. American Journal of Tropical Medicine & Hygiene, 2009; 80:882-888 |
Description | Observational study: Bioko Island Malaria Control Projects, Phase I |
Organisation | Medical Care Development International (MCDI) |
Country | United States |
Sector | Private |
PI Contribution | Design of monitoring and surveillance systems, annual survey design and analsysis, impact evaluation of multiple interventions |
Collaborator Contribution | Multicountry analysis of combined interventions; evaluation of surveillance methods and impact assessment; significant intellectual input and mutual exchange of ideas |
Impact | Phase I found a major reduction in child mortality following an intensification of malaria control initiatives over a 4 year period on Bioko Island, Equatorial Guinea. Results published in Kleinschmidt et al. American Journal of Tropical Medicine & Hygiene, 2009; 80:882-888 |
Description | Observational study: Bioko Island Malaria Control Projects, Phase I |
Organisation | University of Texas |
Country | United States |
Sector | Academic/University |
PI Contribution | Design of monitoring and surveillance systems, annual survey design and analsysis, impact evaluation of multiple interventions |
Collaborator Contribution | Multicountry analysis of combined interventions; evaluation of surveillance methods and impact assessment; significant intellectual input and mutual exchange of ideas |
Impact | Phase I found a major reduction in child mortality following an intensification of malaria control initiatives over a 4 year period on Bioko Island, Equatorial Guinea. Results published in Kleinschmidt et al. American Journal of Tropical Medicine & Hygiene, 2009; 80:882-888 |
Description | Observational study: Bioko Island Malaria Control Projects, Phase I |
Organisation | Yale University |
Country | United States |
Sector | Academic/University |
PI Contribution | Design of monitoring and surveillance systems, annual survey design and analsysis, impact evaluation of multiple interventions |
Collaborator Contribution | Multicountry analysis of combined interventions; evaluation of surveillance methods and impact assessment; significant intellectual input and mutual exchange of ideas |
Impact | Phase I found a major reduction in child mortality following an intensification of malaria control initiatives over a 4 year period on Bioko Island, Equatorial Guinea. Results published in Kleinschmidt et al. American Journal of Tropical Medicine & Hygiene, 2009; 80:882-888 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | Bill and Melinda Gates Foundation |
Country | United States |
Sector | Charity/Non Profit |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | Centers for Disease Control and Prevention (CDC) |
Country | United States |
Sector | Public |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | Georgia Institute of Technology |
Country | United States |
Sector | Academic/University |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | Ghana Health Service |
Country | Ghana |
Sector | Public |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | Health Protection and Research Organisation (HPRO) |
Country | Afghanistan |
Sector | Public |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | HealthNet |
Country | Afghanistan |
Sector | Charity/Non Profit |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | Ifakara Health Institute |
Country | Tanzania, United Republic of |
Sector | Charity/Non Profit |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | Karolinska Institute |
Department | Department of Public Health Sciences |
Country | Sweden |
Sector | Academic/University |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | Kilimanjaro Christian Medical Centre (KCMS) |
Country | Tanzania, United Republic of |
Sector | Hospitals |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | Kintampo Health Research Centre |
Country | Ghana |
Sector | Hospitals |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | Liverpool School of Tropical Medicine |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | Makerere University |
Country | Uganda |
Sector | Academic/University |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | Merlin, Afghanistan |
Country | Afghanistan |
Sector | Private |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | Ministry of Health, Uganda |
Country | Uganda |
Sector | Public |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | National Institute for Medical Research, Tanzania |
Country | Tanzania, United Republic of |
Sector | Public |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | National Malaria Control Programme, Cambodia |
Country | Cambodia |
Sector | Public |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | National Malaria Control Programme, Tanzania |
Country | Tanzania, United Republic of |
Sector | Public |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | University of California, San Francisco |
Country | United States |
Sector | Academic/University |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | University of Cape Town |
Country | South Africa |
Sector | Academic/University |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | University of Copenhagen |
Country | Denmark |
Sector | Academic/University |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | University of Malawi |
Country | Malawi |
Sector | Academic/University |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | University of Nigeria |
Country | Nigeria |
Sector | Academic/University |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | University of Yaoundé |
Country | Cameroon |
Sector | Academic/University |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) |
Organisation | Zanzibar Malaria Control Program |
Country | Tanzania, United Republic of |
Sector | Academic/University |
PI Contribution | Statistical advice, study design |
Collaborator Contribution | Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities |
Impact | Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management |
Start Year | 2008 |
Description | Partnership: HPV in Africa Research Consortium |
Organisation | University of Montpellier |
Country | France |
Sector | Academic/University |
PI Contribution | Contributed to trial design, leading data management and analysis |
Collaborator Contribution | Trial leadership and all other aspects |
Impact | Protocol finalised, baseline data collected, follow-up underway |
Start Year | 2010 |
Description | Partnership: HPV in Africa Research Consortium |
Organisation | University of Ouagadougou |
Department | Centre of International Research for Health |
Country | Burkina Faso |
Sector | Academic/University |
PI Contribution | Contributed to trial design, leading data management and analysis |
Collaborator Contribution | Trial leadership and all other aspects |
Impact | Protocol finalised, baseline data collected, follow-up underway |
Start Year | 2010 |
Description | Partnership: HPV in Africa Research Consortium |
Organisation | University of the Witwatersrand |
Department | Reproductive Health and HIV Research Unit (RHRU) Witwatersrand |
Country | South Africa |
Sector | Academic/University |
PI Contribution | Contributed to trial design, leading data management and analysis |
Collaborator Contribution | Trial leadership and all other aspects |
Impact | Protocol finalised, baseline data collected, follow-up underway |
Start Year | 2010 |
Description | Partnership: IPTi consortium |
Organisation | World Health Organization (WHO) |
Country | Global |
Sector | Public |
PI Contribution | Statistical analysis of the effect of IPTi on serological responses to EPI vaccines |
Collaborator Contribution | Financial contribution |
Impact | Contributed to WHO policy recommendation for IPTi |
Description | Partnership: Integrated Vector Control Consortium (IVCC) |
Organisation | Liverpool School of Tropical Medicine |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Study design, data analaysis, writing and publishing paper |
Collaborator Contribution | Enabled multi country analysis of the effect of combining two malaria vector control methods |
Impact | One publication is being cited in support of Global Fund applications proposing use of combination of vector control methods A second paper on the impact of pyrethroid resistance on operational malaria control in Malawi has just been published. Wondji CS, et al.; 2012, Proceedings of the National Academy of Sciences, Nov 20;109(47):19063-70 |
Start Year | 2007 |
Description | Partnership: Malaria IPT research group Senegal |
Organisation | Institute of Development Research (IRD) |
Department | Research Institute for Development Senegal |
Country | Senegal |
Sector | Academic/University |
PI Contribution | Writing grant proposals and protocols, securing funding, coordinating research projects |
Collaborator Contribution | It has led to new research projects on malaria elimination in W Africa It has led to new research projects on malaria elimination in W Africa |
Impact | Ongoing trial to show safety and effectiveness of malaria IPT delivered through health service. A series of publications are planned. |
Start Year | 2006 |
Description | Partnership: Malaria IPT research group Senegal |
Organisation | University of Dakar |
Country | Senegal |
Sector | Academic/University |
PI Contribution | Writing grant proposals and protocols, securing funding, coordinating research projects |
Collaborator Contribution | It has led to new research projects on malaria elimination in W Africa It has led to new research projects on malaria elimination in W Africa |
Impact | Ongoing trial to show safety and effectiveness of malaria IPT delivered through health service. A series of publications are planned. |
Start Year | 2006 |
Description | Partnership: Malaria Vaccine Advisory Committee |
Organisation | World Health Organization (WHO) |
Country | Global |
Sector | Public |
PI Contribution | Advice on design and analysis of malaria vaccine trials |
Collaborator Contribution | Financial contribution |
Impact | Better trials and more reliable data |
Start Year | 2007 |
Description | Partnership: Malaria in pregnancy consortium |
Organisation | Liverpool School of Tropical Medicine |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Trial design, protocol development, and statistical support |
Collaborator Contribution | Financial contribution |
Impact | Trial of simplified regimens for malaria prevention in pregnancy to start 2010 |
Start Year | 2008 |
Description | Partnership: TB preventive therapy and case finding with the consortium to respond effectively to the AIDS and TB epidemics (CREATE) |
Organisation | Johns Hopkins University |
Country | United States |
Sector | Academic/University |
PI Contribution | TEG has contributed to the design of two clinical trials: Zamstar and Thibela TB. We have also developed the trial protocols and provided statistical support and led on data analysis. |
Collaborator Contribution | Collaborative involvement in statistical analysis of cluster randomised trials and data management of large field-based studies |
Impact | Both trials have been completed successfully. Zamstar results presented at Union World Conference on Lung Health (2011) and CROI (2012). Thibela results presented at CROI (2012) and the South African TB Conference (2012). Trial results have been published - Zamstar in Lancet (2013) and Thibela in NEJM (2014). Several publications are in progress and we intend to apply the learning from both trials to future trial design. |
Start Year | 2006 |
Description | RHASA |
Organisation | Institute of Tropical Medicine Antwerp |
Country | Belgium |
Sector | Academic/University |
PI Contribution | Study design and analysis |
Collaborator Contribution | ITM led the project |
Impact | 2 conference presentations, papers in progress. Disciplines include Epidemiology; Social Science; Laboratory Science |
Start Year | 2012 |
Description | RHASA |
Organisation | National Institute for Medical Research, Tanzania |
Department | Mwanza Intervention Trials Unit (MITU) |
Country | Tanzania, United Republic of |
Sector | Public |
PI Contribution | Study design and analysis |
Collaborator Contribution | ITM led the project |
Impact | 2 conference presentations, papers in progress. Disciplines include Epidemiology; Social Science; Laboratory Science |
Start Year | 2012 |
Description | Review: Design issues in TB drug trials |
Organisation | World Health Organization (WHO) |
Department | Tropical Disease Research (TDR) |
Country | Switzerland |
Sector | Public |
PI Contribution | We assessed TB trial design using 6 criteria on method, outcome and duration |
Collaborator Contribution | Intellectual input and exchange of ideas |
Impact | Findings presented at the 40th Union World Conference on Lung Health in Cancun, 2009. |
Start Year | 2008 |
Description | Seasonal Malaria Chemoprevention working group |
Organisation | Roll Back Malaria |
Country | Switzerland |
Sector | Charity/Non Profit |
PI Contribution | Chairing monitoring and evaluation subcommittee. |
Collaborator Contribution | Members of the monitoring and evaluation subcommittee. |
Impact | Regional meetings of malaria control programme managers in west Africa |
Start Year | 2013 |
Description | Seasonal Malaria Chemoprevention working group |
Organisation | World Health Organization (WHO) |
Country | Global |
Sector | Public |
PI Contribution | Chairing monitoring and evaluation subcommittee. |
Collaborator Contribution | Members of the monitoring and evaluation subcommittee. |
Impact | Regional meetings of malaria control programme managers in west Africa |
Start Year | 2013 |
Description | Seasonal Malaria Chemoprevention working group |
Organisation | Worldwide Antimalarial Resistance Network |
Country | Global |
Sector | Charity/Non Profit |
PI Contribution | Chairing monitoring and evaluation subcommittee. |
Collaborator Contribution | Members of the monitoring and evaluation subcommittee. |
Impact | Regional meetings of malaria control programme managers in west Africa |
Start Year | 2013 |
Description | Statistical support for design and analysis of clinical research projects and support for data management and reporting |
Organisation | Addis Ababa University |
Country | Ethiopia |
Sector | Academic/University |
PI Contribution | Trial design, protocol development, statistical input and data analysis, capacity building, steering and DSMB committee membership |
Collaborator Contribution | Collaborative involvement in a number of Phase II and Phase III trials |
Impact | Development of a specialist Clinical Trials Data Management Centre based in Nairobi. Four trials have been completed. Combined data from two trials showed comparable efficacy and safety of a two-week combination treatment regimen of Paramomycin plus Sodium Stubogluconate (SSG) to the standard one-month SSG monotherapy regimen. The new shorter course combination regimen have been incorporated into national treatment guidelines in Sudan, Kenya, Ethiopia and Uganda and also WHO guidelines. The results of two trials evaluating alternative short-course treatment regimens are being prepared for publication. Funding secured and protocol finalised for a Phase II trial to evaluate a new chemical entity. Results published in Musa et al; PLoS Neglected Diseases, 2012, Hailu et al; PLoS Neglected Diseases, 2010. Protocols published in Edwards et al; Trials, 2011, Omollo et al; Trials, 2011 |
Description | Statistical support for design and analysis of clinical research projects and support for data management and reporting |
Organisation | Drugs for Neglected Diseases initiative (DNDi) |
Country | Switzerland |
Sector | Charity/Non Profit |
PI Contribution | Trial design, protocol development, statistical input and data analysis, capacity building, steering and DSMB committee membership |
Collaborator Contribution | Collaborative involvement in a number of Phase II and Phase III trials |
Impact | Development of a specialist Clinical Trials Data Management Centre based in Nairobi. Four trials have been completed. Combined data from two trials showed comparable efficacy and safety of a two-week combination treatment regimen of Paramomycin plus Sodium Stubogluconate (SSG) to the standard one-month SSG monotherapy regimen. The new shorter course combination regimen have been incorporated into national treatment guidelines in Sudan, Kenya, Ethiopia and Uganda and also WHO guidelines. The results of two trials evaluating alternative short-course treatment regimens are being prepared for publication. Funding secured and protocol finalised for a Phase II trial to evaluate a new chemical entity. Results published in Musa et al; PLoS Neglected Diseases, 2012, Hailu et al; PLoS Neglected Diseases, 2010. Protocols published in Edwards et al; Trials, 2011, Omollo et al; Trials, 2011 |
Description | Statistical support for design and analysis of clinical research projects and support for data management and reporting |
Organisation | Institute for Endemic Diseases IEND |
Country | Sudan |
Sector | Academic/University |
PI Contribution | Trial design, protocol development, statistical input and data analysis, capacity building, steering and DSMB committee membership |
Collaborator Contribution | Collaborative involvement in a number of Phase II and Phase III trials |
Impact | Development of a specialist Clinical Trials Data Management Centre based in Nairobi. Four trials have been completed. Combined data from two trials showed comparable efficacy and safety of a two-week combination treatment regimen of Paramomycin plus Sodium Stubogluconate (SSG) to the standard one-month SSG monotherapy regimen. The new shorter course combination regimen have been incorporated into national treatment guidelines in Sudan, Kenya, Ethiopia and Uganda and also WHO guidelines. The results of two trials evaluating alternative short-course treatment regimens are being prepared for publication. Funding secured and protocol finalised for a Phase II trial to evaluate a new chemical entity. Results published in Musa et al; PLoS Neglected Diseases, 2012, Hailu et al; PLoS Neglected Diseases, 2010. Protocols published in Edwards et al; Trials, 2011, Omollo et al; Trials, 2011 |
Description | Statistical support for design and analysis of clinical research projects and support for data management and reporting |
Organisation | Kenyan Institute for Medical Research (KEMRI) |
Country | Kenya |
Sector | Public |
PI Contribution | Trial design, protocol development, statistical input and data analysis, capacity building, steering and DSMB committee membership |
Collaborator Contribution | Collaborative involvement in a number of Phase II and Phase III trials |
Impact | Development of a specialist Clinical Trials Data Management Centre based in Nairobi. Four trials have been completed. Combined data from two trials showed comparable efficacy and safety of a two-week combination treatment regimen of Paramomycin plus Sodium Stubogluconate (SSG) to the standard one-month SSG monotherapy regimen. The new shorter course combination regimen have been incorporated into national treatment guidelines in Sudan, Kenya, Ethiopia and Uganda and also WHO guidelines. The results of two trials evaluating alternative short-course treatment regimens are being prepared for publication. Funding secured and protocol finalised for a Phase II trial to evaluate a new chemical entity. Results published in Musa et al; PLoS Neglected Diseases, 2012, Hailu et al; PLoS Neglected Diseases, 2010. Protocols published in Edwards et al; Trials, 2011, Omollo et al; Trials, 2011 |
Description | Statistical support for design and analysis of clinical research projects and support for data management and reporting |
Organisation | Makerere University College of Health Sciences |
Country | Uganda |
Sector | Academic/University |
PI Contribution | Trial design, protocol development, statistical input and data analysis, capacity building, steering and DSMB committee membership |
Collaborator Contribution | Collaborative involvement in a number of Phase II and Phase III trials |
Impact | Development of a specialist Clinical Trials Data Management Centre based in Nairobi. Four trials have been completed. Combined data from two trials showed comparable efficacy and safety of a two-week combination treatment regimen of Paramomycin plus Sodium Stubogluconate (SSG) to the standard one-month SSG monotherapy regimen. The new shorter course combination regimen have been incorporated into national treatment guidelines in Sudan, Kenya, Ethiopia and Uganda and also WHO guidelines. The results of two trials evaluating alternative short-course treatment regimens are being prepared for publication. Funding secured and protocol finalised for a Phase II trial to evaluate a new chemical entity. Results published in Musa et al; PLoS Neglected Diseases, 2012, Hailu et al; PLoS Neglected Diseases, 2010. Protocols published in Edwards et al; Trials, 2011, Omollo et al; Trials, 2011 |
Description | Statistical support: Comparison of active and passive surveillance for malaria case detection in Burkina Faso |
Organisation | National Centre for Research and Training on Malaria |
Country | Burkina Faso |
Sector | Public |
PI Contribution | Statistical support- analysis, reporting results. |
Collaborator Contribution | Study conducted in Burkina Faso |
Impact | 1 manuscript currently under review. |
Start Year | 2013 |
Description | Statistical support: Evaluating methods for vaccine efficacy |
Organisation | National University of Singapore |
Country | Singapore |
Sector | Academic/University |
PI Contribution | Methodological research |
Collaborator Contribution | Financial contribution |
Impact | Papers on methods for estimating vaccine efficacy with multiple events |
Start Year | 2007 |
Description | Statistical support: Evaluating methods for vaccine efficacy |
Organisation | University of Hong Kong |
Country | Hong Kong |
Sector | Academic/University |
PI Contribution | Methodological research |
Collaborator Contribution | Financial contribution |
Impact | Papers on methods for estimating vaccine efficacy with multiple events |
Start Year | 2007 |
Description | Statistical support: IPT for the prevention of malaria and related complications in patients with sickle-cell disease in Nigeria |
Organisation | University of Ilorin Teaching Hospital, Nigeria |
Country | Nigeria |
Sector | Academic/University |
PI Contribution | Statistical support- analysis and reporting of results |
Collaborator Contribution | Study conducted in Nigeria |
Impact | Manuscript currently being prepared. |
Start Year | 2013 |
Description | Statistical support: MRC The Gambia |
Organisation | Medical Research Council (MRC) |
Department | MRC Unit, The Gambia |
Country | Gambia |
Sector | Public |
PI Contribution | Research support |
Collaborator Contribution | Increased research output |
Impact | Large number of collaborative research papers and impact on policy. Secured collaborative research funding. |
Description | Statistical support: MRC Uganda |
Organisation | MRC/UVRI Uganda Research Unit on AIDS |
Country | Uganda |
Sector | Public |
PI Contribution | Study design, data analysis, writing and publishing papers, PhD supervision, writing grant proposals, support for quinquennial review proposal |
Collaborator Contribution | Mutually reinforcing collaboration involving exchange of ideas |
Impact | Collaborative studies and research papers; ; successful outcome of MRC quinquennial review |
Description | Statistical support: Missed opportunities for HIV treatment of women linked to HIV testing in pregnancy |
Organisation | University of Nairobi |
Country | Kenya |
Sector | Academic/University |
PI Contribution | PhD supervision |
Collaborator Contribution | Local host for PhD Student |
Impact | Successful completion of fieldwork for study |
Start Year | 2008 |
Description | Statistical support: Mwanza MITU/NIMR |
Organisation | National Institute for Medical Research, Tanzania |
Department | Mwanza Intervention Trials Unit (MITU) |
Country | Tanzania, United Republic of |
Sector | Public |
PI Contribution | Epidemiological and statistical input to field studies; design of new studies and preparation of funding applications; capacity building |
Collaborator Contribution | Collaborative involvement in and field sites for studies of the epidemiology and control of HIV and related infections |
Impact | HIV microbicide and vaccine feasibility studies, and studies of HPV vaccination and epidemiology successfully completed. Studies of chronic diseases and structural interventions to reduce gender violence ongoing |
Start Year | 2006 |
Description | Statistical support: Nutritional support for African adults starting antiretroviral therapy (NUSTART) |
Organisation | National Institute for Medical Research, Tanzania |
Department | Mwanza Research Centre (MRC) |
Country | Tanzania, United Republic of |
Sector | Academic/University |
PI Contribution | Statistical support- analysis, reporting results. PI based at LSHTM. |
Collaborator Contribution | Study sites at UTH and NIMR carry out study. LSHTM PI obtained funding and directing the trial |
Impact | 1 manuscript currently under review. |
Start Year | 2010 |
Description | Statistical support: Nutritional support for African adults starting antiretroviral therapy (NUSTART) |
Organisation | University Teaching Hospital |
Country | Zambia |
Sector | Hospitals |
PI Contribution | Statistical support- analysis, reporting results. PI based at LSHTM. |
Collaborator Contribution | Study sites at UTH and NIMR carry out study. LSHTM PI obtained funding and directing the trial |
Impact | 1 manuscript currently under review. |
Start Year | 2010 |
Description | Statistical support: The relationship between anaemia and pubertal growth spurt in Tanzanian sickle cell patients |
Organisation | Muhimbili Wellcome Programme |
Country | Tanzania, United Republic of |
Sector | Charity/Non Profit |
PI Contribution | Statistical support- analysis and data management |
Collaborator Contribution | Study conducted in Tanzania |
Impact | Research instigated. |
Start Year | 2013 |
Description | Statistical support: Wellcome Trust Bloomsbury Centre Fellows |
Organisation | Wellcome Trust |
Department | Wellcome Trust Bloomsbury Centre |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | Epidemiological and statistical support for Wellcome Trust fellows |
Collaborator Contribution | Collaborative involvement in field research carried out by Wellcome Trust fellows |
Impact | Successful completion of wide range of field studies including publications in peer-review journals |
Description | Statistical support: the impact of maternal infection with M. Tuberculosis on the infant response to BCG immunisation |
Organisation | MRC/UVRI Uganda Research Unit on AIDS |
Country | Uganda |
Sector | Public |
PI Contribution | Statistical design and analysis of the study |
Collaborator Contribution | Design of the study, obtaining funding, co-ordinating the study |
Impact | No outputs as yet. |
Start Year | 2013 |
Description | Study: Epidemiology of border malaria in Northern Namibia: Case control study to determine risk factors for malaria infection |
Organisation | National Malaria Control Programme, Namibia |
Country | Namibia |
Sector | Public |
PI Contribution | Design, study co-ordination, analysis and interpretation of results |
Collaborator Contribution | Design, study co-ordination, analysis and interpretation of results |
Impact | Protocols finalised. |
Start Year | 2012 |
Description | Study: Epidemiology of border malaria in Northern Namibia: Case control study to determine risk factors for malaria infection |
Organisation | University of California |
Country | United States |
Sector | Academic/University |
PI Contribution | Design, study co-ordination, analysis and interpretation of results |
Collaborator Contribution | Design, study co-ordination, analysis and interpretation of results |
Impact | Protocols finalised. |
Start Year | 2012 |
Description | Study: Epidemiology of border malaria in Northern Namibia: Case control study to determine risk factors for malaria infection |
Organisation | University of Namibia |
Country | Namibia |
Sector | Academic/University |
PI Contribution | Design, study co-ordination, analysis and interpretation of results |
Collaborator Contribution | Design, study co-ordination, analysis and interpretation of results |
Impact | Protocols finalised. |
Start Year | 2012 |
Description | Study: Health systems response to chronic diseases in Africa |
Organisation | MRC/UVRI Uganda Research Unit on AIDS |
Country | Uganda |
Sector | Public |
PI Contribution | Contributed to study design, leading statistical analysis |
Collaborator Contribution | Collaborative involvement in field research; trial leadership at Uganda site; significant intellectual input and exchange of ideas |
Impact | Protocol finalised, data collection underway |
Start Year | 2012 |
Description | Study: Health systems response to chronic diseases in Africa |
Organisation | Medical Research Council (MRC) |
Country | United Kingdom |
Sector | Public |
PI Contribution | Contributed to study design, leading statistical analysis |
Collaborator Contribution | Collaborative involvement in field research; trial leadership at Uganda site; significant intellectual input and exchange of ideas |
Impact | Protocol finalised, data collection underway |
Start Year | 2012 |
Description | Study: Health systems response to chronic diseases in Africa |
Organisation | National Institute for Medical Research, Tanzania |
Country | Tanzania, United Republic of |
Sector | Public |
PI Contribution | Contributed to study design, leading statistical analysis |
Collaborator Contribution | Collaborative involvement in field research; trial leadership at Uganda site; significant intellectual input and exchange of ideas |
Impact | Protocol finalised, data collection underway |
Start Year | 2012 |
Description | Study: Preparing for clinical trials of interventions to improve the reproductive health of adolescent girls in sub-Saharan Africa |
Organisation | Institute of Tropical Medicine Antwerp |
Country | Belgium |
Sector | Academic/University |
PI Contribution | Contributed to study design, will lead statistical analysis |
Collaborator Contribution | Collaborative involvement in field research |
Impact | Baisley, K., et al; 2012, Uptake of Voluntary Counselling and Testing among Young People Participating in an HIV Prevention Trial: Comparison of Opt-Out and Opt-In Strategies, PLOS One, 7(7):e42108 |
Start Year | 2011 |
Description | Study: Preparing for clinical trials of interventions to improve the reproductive health of adolescent girls in sub-Saharan Africa |
Organisation | National Institute for Medical Research, Tanzania |
Department | Mwanza Intervention Trials Unit (MITU) |
Country | Tanzania, United Republic of |
Sector | Public |
PI Contribution | Contributed to study design, will lead statistical analysis |
Collaborator Contribution | Collaborative involvement in field research |
Impact | Baisley, K., et al; 2012, Uptake of Voluntary Counselling and Testing among Young People Participating in an HIV Prevention Trial: Comparison of Opt-Out and Opt-In Strategies, PLOS One, 7(7):e42108 |
Start Year | 2011 |
Description | Study: The impact of insecticide resistance on the effectiveness of malaria vector control |
Organisation | Cameroon National Malaria Control Programme |
Country | Cameroon |
Sector | Public |
PI Contribution | Design and co-ordination of epidemiological component of study |
Collaborator Contribution | Funding and overall oversight; Entomological expertise and co-ordination of entomological component of the study; In country co-ordination and execution of the studies. |
Impact | Protocols finalised. Initial data collection completed. |
Start Year | 2010 |
Description | Study: The impact of insecticide resistance on the effectiveness of malaria vector control |
Organisation | Kenya National Malaria Control Programme |
Country | Kenya |
Sector | Public |
PI Contribution | Design and co-ordination of epidemiological component of study |
Collaborator Contribution | Funding and overall oversight; Entomological expertise and co-ordination of entomological component of the study; In country co-ordination and execution of the studies. |
Impact | Protocols finalised. Initial data collection completed. |
Start Year | 2010 |
Description | Study: The impact of insecticide resistance on the effectiveness of malaria vector control |
Organisation | Kenyan Institute for Medical Research (KEMRI) |
Country | Kenya |
Sector | Public |
PI Contribution | Design and co-ordination of epidemiological component of study |
Collaborator Contribution | Funding and overall oversight; Entomological expertise and co-ordination of entomological component of the study; In country co-ordination and execution of the studies. |
Impact | Protocols finalised. Initial data collection completed. |
Start Year | 2010 |
Description | Study: The impact of insecticide resistance on the effectiveness of malaria vector control |
Organisation | Liverpool School of Tropical Medicine |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Design and co-ordination of epidemiological component of study |
Collaborator Contribution | Funding and overall oversight; Entomological expertise and co-ordination of entomological component of the study; In country co-ordination and execution of the studies. |
Impact | Protocols finalised. Initial data collection completed. |
Start Year | 2010 |
Description | Study: The impact of insecticide resistance on the effectiveness of malaria vector control |
Organisation | National Malaria Control Programme (NMCP) |
Country | Ghana |
Sector | Public |
PI Contribution | Design and co-ordination of epidemiological component of study |
Collaborator Contribution | Funding and overall oversight; Entomological expertise and co-ordination of entomological component of the study; In country co-ordination and execution of the studies. |
Impact | Protocols finalised. Initial data collection completed. |
Start Year | 2010 |
Description | Study: The impact of insecticide resistance on the effectiveness of malaria vector control |
Organisation | Sudan's National Malaria Prevention and Control Program (NMCP) |
Country | Sudan |
Sector | Public |
PI Contribution | Design and co-ordination of epidemiological component of study |
Collaborator Contribution | Funding and overall oversight; Entomological expertise and co-ordination of entomological component of the study; In country co-ordination and execution of the studies. |
Impact | Protocols finalised. Initial data collection completed. |
Start Year | 2010 |
Description | Study: The impact of insecticide resistance on the effectiveness of malaria vector control |
Organisation | The National Malaria Control Programme of Benin |
Country | Benin |
Sector | Public |
PI Contribution | Design and co-ordination of epidemiological component of study |
Collaborator Contribution | Funding and overall oversight; Entomological expertise and co-ordination of entomological component of the study; In country co-ordination and execution of the studies. |
Impact | Protocols finalised. Initial data collection completed. |
Start Year | 2010 |
Description | Study: The impact of insecticide resistance on the effectiveness of malaria vector control |
Organisation | World Health Organization (WHO) |
Department | Global Malaria Programme |
Country | Switzerland |
Sector | Charity/Non Profit |
PI Contribution | Design and co-ordination of epidemiological component of study |
Collaborator Contribution | Funding and overall oversight; Entomological expertise and co-ordination of entomological component of the study; In country co-ordination and execution of the studies. |
Impact | Protocols finalised. Initial data collection completed. |
Start Year | 2010 |
Description | Study: modelling and analysis for childhood and pediatric care |
Organisation | Kenyan Institute for Medical Research (KEMRI) |
Country | Kenya |
Sector | Public |
PI Contribution | Statistical analysis and capacity building |
Collaborator Contribution | Significant intellectual input and exchange of ideas. Project leadership. |
Impact | Statistical supportand training was provided to national and international scientists at the KEMRI-Wellcome Trust Research Programme in Nairobi, Kenya. Results published in Ayieko et al; PLoS One, 2012, Gitonga et al; Tropical Medicine and International Health, 2012. Development of materials and teaching on short courses and workshops in Kenya: Clinical Trials, 2011, Multilevel Models, 2010, Specialist Data Management, 2010 |
Start Year | 2010 |
Description | Study: modelling and analysis for childhood and pediatric care |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Statistical analysis and capacity building |
Collaborator Contribution | Significant intellectual input and exchange of ideas. Project leadership. |
Impact | Statistical supportand training was provided to national and international scientists at the KEMRI-Wellcome Trust Research Programme in Nairobi, Kenya. Results published in Ayieko et al; PLoS One, 2012, Gitonga et al; Tropical Medicine and International Health, 2012. Development of materials and teaching on short courses and workshops in Kenya: Clinical Trials, 2011, Multilevel Models, 2010, Specialist Data Management, 2010 |
Start Year | 2010 |
Description | Support and supervision: Uncertainty in estimates of disease burden |
Organisation | UNICEF |
Country | United States |
Sector | Public |
PI Contribution | Directed the work of research fellow |
Collaborator Contribution | Mutually reinforcing collaboration involving exchange of ideas |
Impact | Findings presented to interagency group for mortality estimation, with proposals for improving methods incorporated into methods used by the inter-agency group |
Start Year | 2007 |
Description | Support and supervision: Uncertainty in estimates of disease burden |
Organisation | United Nations (UN) |
Department | UN Population Division |
Country | United States |
Sector | Public |
PI Contribution | Directed the work of research fellow |
Collaborator Contribution | Mutually reinforcing collaboration involving exchange of ideas |
Impact | Findings presented to interagency group for mortality estimation, with proposals for improving methods incorporated into methods used by the inter-agency group |
Start Year | 2007 |
Description | Support and supervision: Uncertainty in estimates of disease burden |
Organisation | World Bank Group |
Country | United States |
Sector | Public |
PI Contribution | Directed the work of research fellow |
Collaborator Contribution | Mutually reinforcing collaboration involving exchange of ideas |
Impact | Findings presented to interagency group for mortality estimation, with proposals for improving methods incorporated into methods used by the inter-agency group |
Start Year | 2007 |
Description | Support and supervision: Uncertainty in estimates of disease burden |
Organisation | World Health Organization (WHO) |
Country | Global |
Sector | Public |
PI Contribution | Directed the work of research fellow |
Collaborator Contribution | Mutually reinforcing collaboration involving exchange of ideas |
Impact | Findings presented to interagency group for mortality estimation, with proposals for improving methods incorporated into methods used by the inter-agency group |
Start Year | 2007 |
Description | Support for design and analysis of clinical research projects & support for data management and reporting of clinical projects |
Organisation | Drugs for Neglected Diseases initiative (DNDi) |
Country | Switzerland |
Sector | Charity/Non Profit |
PI Contribution | We provide ongoing statistical and epidemiological support for trials of the treatment of visceral leishmaniasis in multi-centre studies in East Africa, coordinated from a data centre in KEMRI, Nairobi. The grant also supports participation in a Data Safety and Monitoring Committee for similar trials, also conducted under the sponsorship of DNDi in India and Bangladesh. |
Collaborator Contribution | Implementation of trial, coordination and management. |
Impact | Paper led to informing national treatment policy in Sudan, Kenya, Uganda and Ethiopia. (Sodium stibogluconate plus paramomycin incorporated as the new standard treatment regimin for patients with VL) |
Description | Systematic Review: Male circumcision and the risk of HIV infection in women |
Organisation | Joint United Nations Programme on HIV/AIDS (UNAIDS) |
Country | Global |
Sector | Public |
PI Contribution | Conducted the systematic review and led the publications |
Collaborator Contribution | Significant intellectual input and exchange of ideas |
Impact | Review found little evidence that male circumcision directly reduces risk of HIV in women but also no evidence of harm, informing scale-up of circumcision in Africa. Findings published in Weiss et al. Lancet Infectious Diseases, 2009; 9;669-77 |
Start Year | 2007 |
Description | Systematic Review: Male circumcision and the risk of HIV infection in women |
Organisation | World Health Organization (WHO) |
Country | Global |
Sector | Public |
PI Contribution | Conducted the systematic review and led the publications |
Collaborator Contribution | Significant intellectual input and exchange of ideas |
Impact | Review found little evidence that male circumcision directly reduces risk of HIV in women but also no evidence of harm, informing scale-up of circumcision in Africa. Findings published in Weiss et al. Lancet Infectious Diseases, 2009; 9;669-77 |
Start Year | 2007 |
Description | Systematic Review: Mycoplasma genitalium and HIV infection |
Organisation | Government of South Africa |
Department | Department of Health |
Country | South Africa |
Sector | Public |
PI Contribution | Identified and reviewed epidemiological studies of the association of mycoplasma genitalium and HIV infection in adults. |
Collaborator Contribution | Sample testing; significant intellectual input and exchange of ideas |
Impact | Review found a strong association between mycoplasma genitalium and HIV infection. Findings published in Napierala Mavedzenge and Weiss, AIDS, 2009;23:611-20 |
Start Year | 2008 |
Description | Systematic Review: Mycoplasma genitalium and HIV infection |
Organisation | Medical Research Council (MRC) |
Country | United Kingdom |
Sector | Public |
PI Contribution | Identified and reviewed epidemiological studies of the association of mycoplasma genitalium and HIV infection in adults. |
Collaborator Contribution | Sample testing; significant intellectual input and exchange of ideas |
Impact | Review found a strong association between mycoplasma genitalium and HIV infection. Findings published in Napierala Mavedzenge and Weiss, AIDS, 2009;23:611-20 |
Start Year | 2008 |
Description | Systematic review: Male circumcision and the risk of HPV infection, genital warts and penile cancer in men |
Organisation | World Health Organization (WHO) |
Country | Global |
Sector | Public |
PI Contribution | Identified and reviewed 27 studies on the association between circumcision and HPV DNA. A further 8 papers were identified that evaluated the relationship between circumcision and penile cancer. |
Collaborator Contribution | Significant intellectual input; Mutual exchange of ideas |
Impact | Results suggest that expansion of circumcision services provides partial protection against HPV infection in men, with resulting benefit for women. There was no evidence of an association of circumcision with prevelence of genital warts. |
Start Year | 2009 |
Description | Zinc supplementation in Gambian children with severe pnemonia |
Organisation | Medical Research Council (MRC) |
Department | MRC Unit, The Gambia |
Country | Gambia |
Sector | Public |
PI Contribution | Providing statistical support |
Collaborator Contribution | Conducting a randomised trial on the effectiveness of zinc supplementation (as an adjunct therapy) in childern under 5. |
Impact | Results pending. |
Start Year | 2012 |
Description | AMFm stakeholders consultation |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Has the AMFm mechanism helped to reduce the cost of quality-assured ACTs to patients at public, private for-profit and not-for-profit outlets? Stakeholders were informed of the outcomes of the AMFm project reducing quality-assured ACTs to patients. |
Year(s) Of Engagement Activity | 2013 |
Description | Expert Panel: MEMA kwa Vijana trial, Mwanza |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Primary Audience | Policymakers/politicians |
Results and Impact | Production of technical/policy briefing papers Findings have contributed to development of global policy on adolescent sexual health and HIV |
Year(s) Of Engagement Activity | 2008 |
Description | HPTN 071 (PopART) communications |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Type Of Presentation | Paper Presentation |
Geographic Reach | International |
Primary Audience | Health professionals |
Results and Impact | Press releases and interviews on launch of trial and randomisation ceremony Increased awareness of trial |
Year(s) Of Engagement Activity | 2012,2013 |
Description | HSV-2 trial dissemination activities |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Primary Audience | Health professionals |
Results and Impact | Dissemination of the results from the trial: "Clinical epidemiology of HSV-2 and the impact of HSV suppressive therapy to reduce HIV incidence in high risk women, Tanzania" through workshops, international conferences and meetings and publications in scientific journals. Dissemination of the results from the trial: "Clinical epidemiology of HSV-2 and the impact of HSV suppressive therapy to reduce HIV incidence in high risk women, Tanzania" through workshops. Increased awareness about the association between HIV and HSV-2 in trial participants, scientists and health care workers in Tanzania. |
Year(s) Of Engagement Activity | 2009 |
Description | MEMA Kwa Vijana Further Survey dissemination activities |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Primary Audience | Policymakers/politicians |
Results and Impact | Dissemination of the results from the "MEMA Kwa Vijana Further Survey" (Adolescent Sexual and Reproductive Health intervention) through international and regional workshops. |
Year(s) Of Engagement Activity | 2009 |
Description | Media: Jinja trial |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Primary Audience | Public/other audiences |
Results and Impact | press releases, interviewed by journalists too early to say |
Year(s) Of Engagement Activity | 2009 |
Description | Media: PopArt Funding Decision |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Primary Audience | Public/other audiences |
Results and Impact | Press release and publicity of funding of PopART HIV prevention trial by NIH and Gates Foundation Increased awareness of trial |
Year(s) Of Engagement Activity | 2011 |
Description | Open Day: Entebbe Mother and Baby Study Trial |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Primary Audience | Participants in your research and patient groups |
Results and Impact | Large meeting for all participants and their families, and community field workers involved in trial. Poster presentations, question & answer session Audience informed of trial results |
Year(s) Of Engagement Activity | 2009 |
Description | Presentation: British HIV Association |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Primary Audience | Health professionals |
Results and Impact | Invited talk to the British HIV Association annual meeting Increasing awareness of the association of HIV & male circumcision |
Year(s) Of Engagement Activity | 2006 |
Description | Presentation: Entebbe Mother and Baby Study Trial |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Primary Audience | Policymakers/politicians |
Results and Impact | Dissemination meeting of results to colleagues and stakeholders at the Uganda Ministry of Health Increased awareness of implications of deworming programme for allergy |
Year(s) Of Engagement Activity | 2009 |
Description | Presentation: International AIDS Alliance |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Primary Audience | Policymakers/politicians |
Results and Impact | Invited talk to the International AIDS Alliance Increasing awareness of the association of HIV & male circumcision |
Year(s) Of Engagement Activity | 2008 |
Description | Presentation: Leishmaniasis East Africa Platform |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Dissemination of clinical trial results. Audience was informed of the results of the trial "An open-label, sequential step, safety and efficacy study to determine the optimal single dose of Ambisome for patients with Visceral Leishmaniasis" |
Year(s) Of Engagement Activity | 2009 |
Description | Presentation: Medsin UK Global Health Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Primary Audience | Health professionals |
Results and Impact | Invited talk to the Medsin UK Global Health Conference Increasing awareness of the association of HIV & male circumcision |
Year(s) Of Engagement Activity | 2008 |
Description | Presentation: Pan African Malaria Vector Control Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Primary Audience | Health professionals |
Results and Impact | Invited talk to present evidence on benefit of combined use of insecticide treated nets and indoor residual spraying against malaria Increased use of combined vector control methods in several countries |
Year(s) Of Engagement Activity | 2009 |
Description | Presentation: WHO/UNAIDS Expert Consultation on Male Circumcision & HIV prevention |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | Yes |
Primary Audience | Policymakers/politicians |
Results and Impact | Invited talk to present evidence on male circumcision trials for HIV prevention WHO/UNAIDS recommendation: New Data on Male Circumcision and HIV Prevention: Policy and Programme Implications |
Year(s) Of Engagement Activity | 2007 |
Description | Produced MITU biennial report |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Primary Audience | Health professionals |
Results and Impact | Produced the first MITU biennial report. Distributed to researchers, research collaborations, funding organisations and the media. |
Year(s) Of Engagement Activity | 2009 |
Description | Publication: Tropical Epidemiology Group Biennial Report 2009-10 |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Primary Audience | Participants in your research and patient groups |
Results and Impact | The report summarises our research, outputs and impact over a 2 year period and was sent to over 500 partners, funders and policy makers in March 2011 The report has been well received by colleagues and collaborators. It has also increased the profile and visability of the group both internally and externally |
Year(s) Of Engagement Activity | 2011 |
Description | Roll Back Malaria Vector Control Working Group, Genva, annually |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Type Of Presentation | Paper Presentation |
Geographic Reach | International |
Primary Audience | Participants in your research and patient groups |
Results and Impact | Benefits of complementary use of vector control tools; risk of malarial infection due to holed mosquito nets None to date |
Year(s) Of Engagement Activity | 2010,2011,2012 |
Description | Scientific symposium: HIV Prevention - Where Now? |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Primary Audience | Health professionals |
Results and Impact | The symposium included keynote presentations reviewing the research evidence on major approaches to HIV prevention in adults and focused on the prevention of heterosexual transmission of HIV in Africa. There was discussion of research gaps, future directions and methodological approaches. The media were present. An article on the symposium featured in "Tanzania AIDS Week in Review". |
Year(s) Of Engagement Activity | 2009 |
Description | Stakeholders' Workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | An initial stakeholders' workshop was held in April 2017 to inform, discuss and finalise the intervention package. It was attended by teachers, students and parents from the two intervention schools in addition to the MENISCUS-2 study team, representatives from the Ministry of Education, Ministry of Health and the District Education Officer and NGOs working on menstrual health in Uganda. The workshop generated discussion and questions, and parents of the study participants reported an increased understanding and support for the intervention. |
Year(s) Of Engagement Activity | 2017 |
Description | TEG Biennial Report |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Report publication - Dissemination of recent findings of portfolio of the groups work over the past 2 years Positive response from recipients |
Year(s) Of Engagement Activity | 2013 |
Description | Talk at 6th virtual conference in menstrual hygiene management in schools |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Helen Weiss delivered a talk on the MENISCUS-2 study via Skype at a virtual Menstrual Hygiene Management conference, delivered to an estimated 1000 participants in over 60 countries around the world. |
Year(s) Of Engagement Activity | 2017 |
URL | https://www.mhmvirtualconference.com/ |
Description | Talk at a workshop: "Adolescents and young people living with a disability or chronic conditions sharing research experiences" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Talk delivered by Sarah Harman at a workshop hosted by LSHTM's International Centre for Evidence in Disability: "Adolescents and young people living with a disability or chronic conditions sharing research experiences". The workshop was attended by LSHTM staff and students, but also recorded and made available to the public on the LSHTM website and social media channels. |
Year(s) Of Engagement Activity | 2017 |
URL | http://disabilitycentre.lshtm.ac.uk/disability-seminar-series/ |
Description | Working Group: CIGNIS Trial |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Primary Audience | Health professionals |
Results and Impact | Series of talks followed by poster session and discussions Increased knowledge of micronutrient fortification in HIV-exposed uninfected children |
Year(s) Of Engagement Activity | 2010 |
Description | Working Group: WHO/UNAIDS wesbite |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Primary Audience | Public/other audiences |
Results and Impact | Contributed material to the new WHO/UNAIDS wesbite: www.malecircumcision.org Increased knowledge and awareness of male circumcision and its incorporation in HIV/Aids prevention programming |
Year(s) Of Engagement Activity | 2008 |
Description | Workshop: CIGNIS Trial |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Primary Audience | Participants in your research and patient groups |
Results and Impact | Large meeting for all participants & families; presentations, question and answers session. Audience was informed of trial results |
Year(s) Of Engagement Activity | 2010 |
Description | Workshop: Clinical Trials |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Type Of Presentation | Workshop Facilitator |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Short-course organisation, development of materials, teaching Increased awareness of methodology and conduct of clincial trials |
Year(s) Of Engagement Activity | 2011 |
Description | Workshop: Determining the role of IPT in malaria control |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Primary Audience | Health professionals |
Results and Impact | Review of evidence on potential role of IPTc for malaria control, for national programmes and WHO representatives A working group was established to prepare a report on IPTc for submission to WHO |
Year(s) Of Engagement Activity | 2008 |
Description | Workshop: Herpes suppressive therapy trial, Mwanza |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Primary Audience | Policymakers/politicians |
Results and Impact | Dissemination workshops for policymakers and other stakeholders in Tanzania Attendees better informed about Herpes suppressive therapy trials in Mwanza, Tanzania |
Year(s) Of Engagement Activity | 2007 |
Description | Workshop: Jinja trial |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Primary Audience | Participants in your research and patient groups |
Results and Impact | Large meeting for all patients, community members, health care staff. Gave presentations, and held a question and answer session. Audience was informed |
Year(s) Of Engagement Activity | 2009 |
Description | Workshop: MDP301 trial of Pro2000 microbicide gel |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Primary Audience | Participants in your research and patient groups |
Results and Impact | Subsantial proportion of women participating in trial attended dissemination workshops NA |
Year(s) Of Engagement Activity | 2010 |
Description | Workshop: MEMA kwa Vijana trial, Mwanza |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Primary Audience | Policymakers/politicians |
Results and Impact | Dissemination workshops for policymakers and other stakeholders in Tanzania Findings have contributed to development of global policy on adolescent sexual health and HIV |
Year(s) Of Engagement Activity | 2008 |
Description | Workshop: Microbicide feasibility study in Mwanza |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Primary Audience | Policymakers/politicians |
Results and Impact | National workshop in Tanzania to present results of study to government and non-governmental organisations Increased awareness of research to develop effective HIV prevention tools |
Year(s) Of Engagement Activity | 2011 |
Description | Workshop: Multilevel Models |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Type Of Presentation | Workshop Facilitator |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Short-course organisation, development of materials, teaching Increased awareness of methods and applications for multilevel continuous and binary data |
Year(s) Of Engagement Activity | 2010 |
Description | Workshop: Specialist Data Management |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Type Of Presentation | Workshop Facilitator |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Workshop organisation, series of talks followed by discussions Increased awareness of specialist data management activities for clinical trials and networking in the East Africa region |
Year(s) Of Engagement Activity | 2010 |