Strategic Appointment - Professorship

Lead Research Organisation: University of Warwick
Department Name: Warwick Medical School

Abstract

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Description Programme Grant
Amount £1,800,000 (GBP)
Funding ID G1001536 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2011 
End 09/2016
 
Description Research Development Fund (Warwick University)
Amount £21,000 (GBP)
Organisation University of Warwick 
Sector Academic/University
Country United Kingdom
Start 03/2008 
End 02/2010
 
Description Aberdeen Collaboration 
Organisation University of Aberdeen
Department School of Medicine & Dentistry Aberdeen
Country United Kingdom 
Sector Academic/University 
PI Contribution intellectual input, analytical help with plasma samples
Collaborator Contribution provided further insight into signaling functions of nitrite; resultied in a joint programme grant application (originally submitted in 2010; awarded in 2012)
Impact publications: PMID: 20889759 (two further papers under review) MRC grant application (jointly with Prof Frenneaux)
Start Year 2010
 
Description Edinburgh Skin Collaboration 
Organisation University of Edinburgh
Department Department of Dermatology
Country United Kingdom 
Sector Academic/University 
PI Contribution we provided analytical expertise and services to measure human blood samples taken during a study on cardiovascular changes induced by UV light
Collaborator Contribution stimulated our interest in the possible roles of nitric oxide (NO) and nitrite in skin physiology a publication in the top Dermatology journal (JID) has been accepted, pending minor revisions (Nov 2013)
Impact publications: PMID: 20215123 a joint grant application to the ERC (with Dr. Weller) has been submitted; unsuccessful; a revised grant application to the BHF is currently in preparation
Start Year 2008
 
Description Mass General Hypoxia Collaboration 
Organisation Massachusetts General Hospital
Country United States 
Sector Hospitals 
PI Contribution we provide analytical expertise and services to quantify NO metabolites in blood and tissues of animals exposed to nitric oxide by inhalation
Collaborator Contribution continuation of long-standing collaboration with colleagues from Harvard University/Mass General; our collaborators provided samples from animal studies aimed at better understanding the fate of nitric oxide (NO) following inhalation in vivo - output from earlier work in Boston was published in 2008 (Nagasaka et al, Anesthesiology. 2008 Oct;109(4):675-82); more recent collaborative studies attempt to understand how NO metabolism changes under hypoxic conditions one further publication, describing the half-life of NO metabolites in blood and tissues, is in preparation
Impact Nagasaka et al, Anesthesiology. 2008 Oct;109(4):675-82; PMID: 18813047 This paper was not listed under outputs because this prior work was not supported by MRC funds.
 
Description UCL-CASE Hypoxia Collaboration 
Organisation University College London
Department Institute of Child Health
Country United Kingdom 
Sector Academic/University 
PI Contribution We agreed to provide analytical expertise and services in relation to biomarker research aimed at elucidating the molecular underpinnings of adaptation to hypoxia in humans.
Collaborator Contribution The collaborators granted access to plasma samples taken during controlled ascent to altitude (Caudwell Extreme Everest Expedition 2007), which enabled us to continue research on the role of nitric oxide (NO) in successfully adapting to chronic hypoxia (suggested by the output from a previous collaboration with US collegues before my return to Europe: Erzurum et al, Proc Natl Acad Sci U S A. 2007 Nov 6;104(45):17593-8).
Impact We accomplished to measure a large number of biochemical indices of metabolic and hormonal changes in response to hypobaric hypoxia in participants of a mountaineering expedition (CXE 2007) and are currently in the process of extracting information by correlating these data to physiological variables using statistics/bioinformatics tools. This collaboration has resulted in one (unsuccessful) grant application to the MRC in the past (G0801567). One paper published in Sci Reports, another one currently under review; several others in preparation
Start Year 2007