Advancing the Application of Magnetic Resonance in Cancer: Structural, Functional and Molecular Studies of Tumours and

Lead Research Organisation: Institute of Cancer Research
Department Name: Division of Radiotherapy and Imaging

Abstract

This proposal aims to establish a leading edge 3T magnetic resonance facility to support major
programmes of research in cancer imaging that focus on tumour detection, assessment of
disease extent and aggressiveness, and evaluation of new cancer therapies. The proposal will
build on 20 years of experience in applying magnetic resonance to cancer at The Institute of
Cancer Research and the Royal Marsden Hospital enhancing major research programmes
funded through Cancer Research UK and through NHS research and development activities.
The increased signal available at 3T allows high-resolution images for improved tumour
detection, but also enables functional information to be acquired, which may not be possible at
conventional field strengths. Much of the planned research uses functional images, where the
behaviour and characteristics of tumour are measured, in addition to their extent. The higher
field strength provides increased sensitivity to signals from MR contrast agents, allowing more
accurate assessment of tumour blood supply. The water composition and viability of cells within
a tumour will also be assessed more easily and the detailed interrogation of biochemical
pathways will be made possible using multi-nuclear MR spectroscopy. This will enable
assessment of the action of new anti-cancer drugs on specific processes in cells.

Technical Summary

Support for 3T clinical MRI scanner to add to existing state of art CT, PET-CT and SPECT facilities. System to be integrated within current MR unit within Royal Marsden NHS Foundation Trust at Sutton which is jointly operated with ICR.

Provide a multi-modality molecular imaging resource to probe tumor biology: identify metabolic signatures of tumors; develop functional imaging (tumour vascularity, perfusion, oxygenation and cellularity) to monitor treatment response & guide treatment strategies in adult & paediatric patients;characterize tumour heterogeneity and link to prognosis; improve tumour staging; develop biomarkers of drug action.

Publications

10 25 50

 
Description CIRC management group Singapore
Geographic Reach Europe 
Policy Influence Type Participation in advisory committee
 
Description EPSRC Strategy Review
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description Incidental Findings
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
URL http://www.bmj.com/content/351/bmj.h5190.long
 
Description NCRI Imaging Review
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description Bursary/Bowel Disease Research Foundation
Amount £15,956 (GBP)
Organisation Bowel Disease Research Foundation (BDRF) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description CLINICAL RESEARCH FACILITY
Amount £547,381 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2017 
End 03/2022
 
Description CR-UK Cancer Imaging Centre
Amount £7,607,000 (GBP)
Funding ID C1060/A16464 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2013 
End 11/2018
 
Description CR-UK and EPSRC Cancer Imaging Centre
Amount £9,000,000 (GBP)
Funding ID C1060/A10334 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2008 
End 11/2013
 
Description CRUK BIDD
Amount £162,000 (GBP)
Funding ID C7270/A13149 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description CRUK Biological Sciences Committee - Equipment Allocation
Amount £66,539 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2011 
End 03/2012
 
Description CRUK Radiotherapy Research Programme
Amount £2,500,000 (GBP)
Funding ID A19727 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description CRUK and EPSRC Paediatric Cancer Imaging Programme
Amount £2,500,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2008 
End 11/2014
 
Description Collaborative Award in Science application Multi-User Ultra-High Field Clinical Imaging Research Centre for London
Amount £4,000,000 (GBP)
Funding ID 201526/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description EP/H046410/1 EPSRC Intelligent Imaging: Motion, Form and Function Across Scale
Amount £948,461 (GBP)
Funding ID EP/H046410/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description EP/H046526/1 EPSRC Platform Grant: Multimodality Techniques for Cancer Diagnosis and Therapy
Amount £1,400,150 (GBP)
Funding ID EP/H046526/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Efficiency and Mechanism Evaluation
Amount £636,675 (GBP)
Funding ID 16/68/34 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description Experimental Cancer Medicine Centres
Amount £2,500,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2012 
End 03/2017
 
Description Focused Ultrasound Foundation Centre of Excellence
Amount $450,000 (USD)
Funding ID none 
Organisation Focused Ultrasound Foundation 
Sector Charity/Non Profit
Country United States
Start 10/2013 
End 09/2016
 
Description GAP2 FDHT
Amount £476,925 (GBP)
Organisation Movember Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2013 
End 09/2015
 
Description MRC Developmental Pathway funding scheme
Amount £200,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description MRC MR-Linac Clinical Infrastructure award
Amount £9,619,509 (GBP)
Funding ID MR/M009068/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description NIHR CRF
Amount £2,812,128 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 09/2012 
End 03/2017
 
Description NIHR Healthcare Science Fellowship
Amount £203,251 (GBP)
Funding ID HCS-D13-04-002 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 03/2014 
End 02/2017
 
Description NIHR Senior Investigator Award
Amount £75,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2008 
End 03/2013
 
Description NIHR Senior Investigator Award
Amount £45,000 (GBP)
Funding ID NF-SI-0512-10162 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2013 
End 03/2016
 
Description NIHR TRF
Amount £198,520 (GBP)
Funding ID TRF-2013-06-003 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 11/2013 
End 10/2015
 
Description National Cancer Institute (NCI) R01 grant
Amount £266,210 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start  
 
Title RF Coils 
Description New 1H/31P rf surface coil design is being tested. Also internal cervix Rx coil. 
Type Of Material Physiological assessment or outcome measure 
Provided To Others? No  
Impact A coil for 31P/1H MRS has been built and is being tested. A coil for cervical imaging and spectroscopy has been built and is being tested. A coil for measuring solution-state 13C DNP compounds has been interfaced and preliminary measurements performed. 
 
Title multiple quantum lactate measurements 
Description magneetic resonance technique for measuring lactate in vivo 
Type Of Material Physiological assessment or outcome measure 
Provided To Others? No  
Impact still in implementation 
 
Description Cancer Imaging Centres Collaboration 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Projects in bioinformatics, training, clinical trials, preclinical investigations
Collaborator Contribution training, clinical trials, radiopharmaceutical development
Impact potential collaboration agreement with GE
Start Year 2013
 
Description Cancer Imaging Centres Collaboration 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Projects in bioinformatics, training, clinical trials, preclinical investigations
Collaborator Contribution training, clinical trials, radiopharmaceutical development
Impact potential collaboration agreement with GE
Start Year 2013
 
Description Cancer Imaging Centres Collaboration 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Projects in bioinformatics, training, clinical trials, preclinical investigations
Collaborator Contribution training, clinical trials, radiopharmaceutical development
Impact potential collaboration agreement with GE
Start Year 2013
 
Description Cancer Imaging Centres Collaboration 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution Projects in bioinformatics, training, clinical trials, preclinical investigations
Collaborator Contribution training, clinical trials, radiopharmaceutical development
Impact potential collaboration agreement with GE
Start Year 2013
 
Description Cancer Imaging Centres Collaboration 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Projects in bioinformatics, training, clinical trials, preclinical investigations
Collaborator Contribution training, clinical trials, radiopharmaceutical development
Impact potential collaboration agreement with GE
Start Year 2013
 
Description DNP Imaging 
Organisation ETH Zurich
Department Institute for Biomedical Engineering
Country Switzerland 
Sector Public 
PI Contribution Implementation and evaluation of mew imaging methods using hyperpolarised probes
Collaborator Contribution Novel spectroscopic imaging methods
Impact Abstracts to international meetings Multidisciplinary: Engineering, Physics, Chemistry, Biochemistry
Start Year 2010
 
Description London clinical 7T consortium 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution This collaboration is establishing, with support for the Wellcome Trust, a clinical 7T MR system to support research in London
Collaborator Contribution Together we have developed scientific programmes in different medical areas where 7T MRI is relevant. WE will seek more specific funding of these aspects. Funding for the 7T has been awarded.
Impact Wellcome Award £4M. Very multidisciplinary, many specialities, clinical, physics, radiology, surgery, neurology, psychiatry, engineering.
Start Year 2013
 
Description London clinical 7T consortium 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution This collaboration is establishing, with support for the Wellcome Trust, a clinical 7T MR system to support research in London
Collaborator Contribution Together we have developed scientific programmes in different medical areas where 7T MRI is relevant. WE will seek more specific funding of these aspects. Funding for the 7T has been awarded.
Impact Wellcome Award £4M. Very multidisciplinary, many specialities, clinical, physics, radiology, surgery, neurology, psychiatry, engineering.
Start Year 2013
 
Description London clinical 7T consortium 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution This collaboration is establishing, with support for the Wellcome Trust, a clinical 7T MR system to support research in London
Collaborator Contribution Together we have developed scientific programmes in different medical areas where 7T MRI is relevant. WE will seek more specific funding of these aspects. Funding for the 7T has been awarded.
Impact Wellcome Award £4M. Very multidisciplinary, many specialities, clinical, physics, radiology, surgery, neurology, psychiatry, engineering.
Start Year 2013
 
Description MCT1 inhibitor clinical trial 
Organisation Cancer Research UK
Department CRUK Centre for Cancer Therapeutics
Country United Kingdom 
Sector Private 
PI Contribution This is a phase I clinical trial of a new MCT1 inhibitor as part of a collaboration between CRUK and Astra Zeneca. We have developed new measurement methodologies for pH and lactate, and established the former at the two clinical centres, analyzing the results to data. We plan to introduce lactate measurements at both centres in the next stage. We have also performed cell and in vivo preclinical measurements as a part of this collaboration to guide further studies.
Collaborator Contribution CRUK CCT is funding an dcoordinating this study. The clinical trial PI is based at Newcastle. Our Drug Development Unit is contributing measurements.
Impact Multidisciplinary: Clinical Oncology, radiology, pharmacology, pathology, chemistry, molecular biology, physics, imaging
Start Year 2013
 
Description MCT1 inhibitor clinical trial 
Organisation Newcastle University
Department Northern Institute for Cancer Research Newcastle
Country United Kingdom 
Sector Academic/University 
PI Contribution This is a phase I clinical trial of a new MCT1 inhibitor as part of a collaboration between CRUK and Astra Zeneca. We have developed new measurement methodologies for pH and lactate, and established the former at the two clinical centres, analyzing the results to data. We plan to introduce lactate measurements at both centres in the next stage. We have also performed cell and in vivo preclinical measurements as a part of this collaboration to guide further studies.
Collaborator Contribution CRUK CCT is funding an dcoordinating this study. The clinical trial PI is based at Newcastle. Our Drug Development Unit is contributing measurements.
Impact Multidisciplinary: Clinical Oncology, radiology, pharmacology, pathology, chemistry, molecular biology, physics, imaging
Start Year 2013
 
Description NCI 31P project 
Organisation Columbia University Medical Center
Department Department of Radiology
Country United States 
Sector Academic/University 
PI Contribution Expertise, accruing patients, implementing and testing methods
Collaborator Contribution Shared expertise, improved methodology
Impact See publication list multicentre evaluation of methodology. In vivo 31P MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial. Arias-Mendoza F, Payne GS, Zakian KL, Schwarz AJ, Stubbs M, Stoyanova R, Ballon D, Howe FA, Koutcher JA, Leach MO, Griffiths JR, Heerschap A, Glickson JD, Nelson SJ, Evelhoch JL, Charles HC, Brown TR. NMR Biomed. 2006 Jun;19(4):504-12. Multidisciplinary Physics, Engineering, Medicine, Biochemistry
Start Year 2007
 
Description design and testing of specialised components 
Organisation Specialty Magnetics Ltd
Country United States 
Sector Private 
PI Contribution Investigating feasibility of prototype devices, checking MR compatibility of such devices.
Collaborator Contribution Test devices for improved diagnosis and treatment of cancer
Impact Aiding understanding of requirements for breast imaging and biopsy equipment, and the compatibility of display and control equipment.
Start Year 2010
 
Title Software for breast cancer analysis 
Description A range of software to analyse MRI breast images, including segmentation and density analysis 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2012
Licensed Yes
Impact Demonstration of association between density and breast cancer risk
 
Title MCT1 inhibitor AZD3965 
Description This is an early stage clinical trial supported by DR-UK DDO under an agreement with AstraZeneca. Advanced MRI techniques are being used to identify proof of mechanism of action in Phase I/II trial jointly with Univ Newcastle 
Type Therapeutic Intervention - Drug
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2013
Development Status Under active development/distribution
Clinical Trial? Yes
Impact Measurements of pH standardised and implemented at 2 centres. Publication on methodology now on line. 
 
Description Developing Policy on Incidental Findings 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Health professionals
Results and Impact 85 Professionals including ethicists, funders, public attended a workshop in 2010.
Ethical Management of Research Imaging
1st July 2010; Wellcome Trust, Gibbs Building, 215 Euston Road, London, UK
Issues were identified, a consensus reached on some topics, minimum standards developed. A report has been made available via web sites. A publication has been submitted.

Discussion identified a range of views and approaches amongst researchers. Consensus was achieved on a minimum standard. A publication has been submitted.
Year(s) Of Engagement Activity 2010,2011,2012,2013
 
Description Discovery Club 2012 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Supporters
Results and Impact 60 or so leading individuals attended, leading to positive funding support for research

Invitations to propose funding requests to a number of Trusts.
Year(s) Of Engagement Activity 2012
 
Description Imaging research open evening 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact This related to NIHR Clinical Research Facilities coordinated events, designed to encourage participation in clinical trials and inform potential participants of what imaging studies involved
Year(s) Of Engagement Activity 2015
 
Description Opening of 3T facility 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Press coverage in national and local media

Coverage in national and local press and other media
Year(s) Of Engagement Activity 2009
 
Description PPI imaging open evening 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Talks, posters and visits resulted in discussion; questionnaires, quiz engaged interest

Engagement with a wide number of individuals,and charities, resulting in better understanding of role of imaging
Year(s) Of Engagement Activity 2014
 
Description PPI strategy and engagement with patient representatives 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact Several patient representatives have been engaged and attend some meetings of Clinical Research Facility Management Group

PPI strategy developed with their input approved by NIHR.
Year(s) Of Engagement Activity 2013
 
Description Patient Partnership for fellowship 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact Guidance in the scientific programme, and arrangements for patient liaison.

Successful Fellowship application.
Year(s) Of Engagement Activity 2012,2013
 
Description Radio Inteview 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact INterview on the Naked Scientist BBC Programme broadcast to local radio, internet and podcast, together with responding to audience questions

Positive response from broadcasters and Institute Press Office.
Year(s) Of Engagement Activity 2011