Derivation of clinical grade embryonic stem cell lines in Manchester

Lead Research Organisation: University of Manchester
Department Name: Medical and Human Sciences

Abstract

During in vitro fertilisation (IVF) treatment many eggs and embryos fail to develop normally and are unsuitable for clinical use and routinely discarded at an early stage. Other embryos are frozen for future use. The purpose of this research is to use these eggs and embryos, with appropriate patient consent, to make human embryonic stem cells. Embryo stem cells are special cells that appear to be able to develop into all cells found in the body. As such they can be used to study early embryo development, how specialized cells form or deteriorate, to test drugs for toxicity, or for therapeutic use in the treatment of degenerative disease or tissue damage. Although many human embryonic stem cell ?lines? exist throughout the world, these are all research grade and are unlikely to be suitable for treatment of diseases. The aim of the proposed research is therefore to make new embryonic stem cells under highly regulated and clinically clean conditions, suitable for transplantation. We have new IVF and stem cell laboratories built and run to these standards and the current proposal requests funding to maintain and run these facilities in order to maximise the production of clinical grade embryonic stem cells. These new cell lines will be deposited in the UK Stem Cell Bank and any clinical treatments and commercial exploitation organised by Central Manchester NHS Trust and the University of Manchester together with the Medical Research Council.

Technical Summary

The purpose of this proposal is to derive and fully characterise 6-8 new clinical grade human embryonic stem cell (hESC) lines. It will extend the operation of the currently funded NW Embryonic Stem Cell Centre (NWESCC) in Manchester until 2011 in order to fulfil this aim. Recently established GMP cleanroom laboratory facilities funded by the MRC (IVF laboratories at St Mary?s Hospital) and the NW Development Agency (hESC laboratories at the University of Manchester) will be used. Our existing expertise in patient consenting, embryology, derivation and characterisation of hESC lines, Quality Management, and regulatory issues will be exploited and built upon. This will be extended via links and collaborations with other centres eligible for this work, including Edinburgh/Roslin Cells, Nottingham, King?s London, and Birmingham. Embryos from three sources will be used for derivation, including (i) surplus embryos from fresh IVF cycles, (ii) immature or failed-to-fertilise oocytes activated with chemical/parthenogenetic stimuli, and (iii) high quality embryos cryopreserved at the pronucleate stage. Over the last 12-18 months a large number of oocytes and embryos have been donated from the IVF programmes at St Mary?s and Manchester Fertility Services, leading to the derivation of 3 well established research grade hESC lines, RCM-1 (in collaboration with Roslin Cells, Edinburgh), Man-1 and Man-2, the first two of which have been submitted to the UK Stem Cell Bank. Clinical grade lines will be derived employing our established standard operating procedures which will be developed and refined. These make use of significant advances by NWESCC in the areas of xeno-free derivation and culture, feeder-free culture media and a GMP human fibroblast feeder cell line. Regulatory compliance will be maintained via our established Quality Management system and in conjunction with intellectual property departments at the University of Manchester and CMMC NHS Trust who will assist with commercial exploitation of GMP hESC lines in conjunction with MRC.

Publications

10 25 50
 
Description Cochrane guideline on embryo culture temperature
Geographic Reach Europe 
Policy Influence Type Membership of a guideline committee
 
Description ESHRE working group on the impact of embryo culture medium on long term health
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
 
Description HFEA Information for Quality programme
Geographic Reach National 
Policy Influence Type Participation in advisory committee
Impact acting as advisor to Human Fertilisation and Embryology Authority Information for quality programme which aims to improve regulatory oversight of the field including stem cell derivation, and improve information to patients and for delivery of clinical IVF services.
 
Description Human Fertilisation and Embryology Authority Traffic light system for add on treatments in ART
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact The Human Fertilisation and Embryology Authority developed a Traffic Light system of graded evidence on the effectiveness of so-called add ons to ART treatment for infertility.
URL https://www.hfea.gov.uk/treatments/explore-all-treatments/treatment-add-ons/
 
Description Influencing policy towards patenting of discoveries using hESC lines
Geographic Reach Europe 
Policy Influence Type Membership of a guideline committee
 
Description Member of TERMIS Scientific Advisory Board
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Membership of HFEA's Scientific and Clinical Advances committee
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Advising the HFEA on changes in regulation on ART practice, embryology, embryonic stem cell biology
 
Description National Clinical human Embryonic Stem Cell Forum
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact Standardisation of requirements for clinical grade embryonic stem cell lines. Prof Brison is vice-chair of this group
 
Description Setting standards for procurement of embryonic stem cells at clinical grade
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Stem Cells for Safer Medicine Panel Member
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Arthritis Research UK Project Grant
Amount £195,453 (GBP)
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2010 
End 07/2013
 
Description BBSRC icase studentship (with Argo)
Amount £110,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2014 
End 12/2017
 
Description Chondrocytes from clinical grade embryonic stem cells
Amount £793,000 (GBP)
Funding ID MR/L004992/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 06/2014 
End 05/2017
 
Description Diabetes UK
Amount £570,000 (GBP)
Organisation Diabetes UK 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2015 
End 10/2018
 
Description EME - EFREEZE
Amount £700,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 08/2015 
End 07/2018
 
Description EME - HaBSelect
Amount £1,000,000 (GBP)
Funding ID EME/11/14/34 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 01/2014 
End 12/2015
 
Description EU FP7, Sybil; Systems Biology for the functional validation of genetic determinants of skeletal diseases.
Amount £1,180,000 (GBP)
Funding ID 602300 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 10/2014 
End 10/2018
 
Description EpiHealth: Linking perturbed maternal environment during periconceptional development, due to diabetes, obesity or assisted reproductive technologies, and altered health during ageing. Grant agreement number: 278418
Amount £385,264 (GBP)
Funding ID 278418 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 11/2011 
End 11/2013
 
Description EpiHealthNet
Amount € 285,607 (EUR)
Funding ID 317146 
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 10/2013 
End 09/2016
 
Description Grant funding
Amount £120,000 (GBP)
Organisation Newlife 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2017 
End 05/2021
 
Description Kidneys for Life
Amount £15,000 (GBP)
Organisation Kidneys for Life 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2016 
End 12/2016
 
Description MRC (with Hardingham and Brison) Chondrocytes from clinical grade embryonic stem cells
Amount £793,000 (GBP)
Funding ID MR/L004992/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 06/2014 
End 06/2017
 
Description MRC project grant
Amount £1,290,000 (GBP)
Funding ID MR/M017354/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 05/2015 
End 04/2017
 
Description NIHR Clinical fellowship
Amount £270,000 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 06/2016 
End 05/2021
 
Description Sparking Impact
Amount £10,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 07/2014 
End 12/2014
 
Description Stoneygate Feehally research award
Amount £251,813 (GBP)
Organisation Kidney Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2017 
End 04/2020
 
Description Studentship sponsor
Amount £22,500 (GBP)
Organisation University of Manchester 
Sector Academic/University
Country United Kingdom
Start 01/2012 
End 12/2014
 
Description TSB - Expandable clinical grade feeder cells for hESc derivation
Amount £468,000 (GBP)
Funding ID 101107 
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 04/2012 
End 06/2014
 
Description TSB - GMP grade human dermal fibroblasts as feeders for derivation of clinically useable human ES cells
Amount £40,000 (GBP)
Funding ID 130335 
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 06/2010 
End 03/2011
 
Description Technology Strategy Board - Regenerative Medicine Tools & Technologies Feasibility Studies
Amount £49,294 (GBP)
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 07/2010 
End 03/2011
 
Description Toxicology programme
Amount £80,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2015 
End 12/2018
 
Description UK national ART cohort - Population and Systems Medicine Board
Amount £200,000 (GBP)
Funding ID MR/L020335/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2014 
End 08/2016
 
Description UK-China Fellowships for Excellence /Department for Business, Innovation and Skills (BIS)
Amount £9,600 (GBP)
Organisation Department for Business, Energy & Industrial Strategy 
Sector Public
Country United Kingdom
Start 03/2011 
End 02/2012
 
Description UKRMP (inter-University strategic grant) hub Safety of Stem cells
Amount £3,500,000 (GBP)
Funding ID MR/K026739/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2013 
End 09/2018
 
Description Wellbeing of Women
Amount £133,000 (GBP)
Organisation Royal College of Obstetricians and Gynaecologists (RCOG) 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2013 
End 10/2015
 
Title Clinical grade human embryonic stem cell lines 
Description Human embryonic stem cell lines which have been derived and stored at clinical grade standards suitable for use in clinical therapies. 
Type Of Material Cell line 
Provided To Others? No  
Impact Not known yet 
 
Title More human Embyonic Stem Cell lines, including xeno-free lines 
Description Human embryonic stem cell lines. Research grade and clinical grade. 
Type Of Material Cell line 
Year Produced 2008 
Provided To Others? Yes  
Impact ISCI2 project on genetic characterisation of lines (see nature Biotechnology publication). 
 
Title Six Clinical grade Manchester hESC lined completed due diligence and made avialble by UKSCB 
Description Manchester Clinical grade hESCs now registered as EUCTD compliant and launched by Stem Cell bank 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2017 
Provided To Others? Yes  
Impact Provision at research grade lines in in 2015. Lead to several papers from Hay and Kunath groups. Now available as clinical grade though UKSCB 
 
Title embryo cDNAs 
Description amplified cDNAs from individual human embryos suitable for gene expression analysis 
Type Of Material Database/Collection of Data/Biological Samples 
Year Produced 2010 
Provided To Others? Yes  
Impact Sneddon et al 2012 paper 
 
Title embryo microarray data 
Description gene expression data from single human embryos available for bioinformatic analysis 
Type Of Material Database/Collection of Data/Biological Samples 
Year Produced 2011 
Provided To Others? Yes  
Impact publications in preparation 
 
Title human Embryonic Stem Cell lines 
Description human Embryonic Stem Cell lines 
Type Of Material Cell line 
Year Produced 2010 
Provided To Others? Yes  
Impact Results not yet known. 
 
Description Collaboration with Don Whitley Scientific 
Organisation Don Whitley Scientific Limited
Country United Kingdom 
Sector Hospitals 
PI Contribution To develop and evaluate better ways of genrating good manufacturing (clinical) standrd high quality induced pluripotent stem cells at low cost using an environmental work station
Collaborator Contribution DWS have a work staion whihc h they will upgrade a redesign for controlled atmosphere working. Applied to Innovate for fudning but narrowly missed
Impact innovate grant...will put in for CIC and pos P2D
Start Year 2015
 
Description Collaboration with ISCI2 
Organisation University of Sheffield
Department Department of Biomedical Science
Country United Kingdom 
Sector Academic/University 
PI Contribution Dervied and characterised novel stem cell lines in Manchester and submitted these to international initiative for genetic characterisation.
Collaborator Contribution Derived and characterised novel stem cell lines in Manchester and submitted these to international initiative for genetic characterisation.
Impact Paper in press in Nature Biotechnology describing genetic characterisation of 127 embryonic stem cell lines. Disciplines covered are stem cell biology, embryology and genetics.
Start Year 2009
 
Description Collaboration with Intercytex for development of GMP grade human dermal fibroblasts as feeders for derivation of clinically useable human ES cells 
Organisation Intercytex
Country United Kingdom 
Sector Private 
PI Contribution Development of GMP grade human dermal fibroblasts as feeders for derivation of clinically useable human ES cells
Collaborator Contribution Development of GMP grade human dermal fibroblasts as feeders for derivation of clinically useable human ES cells
Impact Grant income of £40,000; collaboration with Intercytex to jointly run GMP laboratories; and successful application to MHRA for product manufacturing licence. This collaboration covers the following disiplines: embryology, stem cell biology, quality management, wound healing.
Start Year 2010
 
Description Collaboration with Kings College, University of London 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Sharing bext practice with King's via regular meetings.
Collaborator Contribution Sharing bext practice with King's via regular meetings.
Impact Collaboration has resulted in clinical grade stem cell lines ready for submission to UKSCB and a Science Media Centre event has been organised to publicise submission of clinical grade stem cell lines to UK Stem Cell Bank. Disciplines covered are embryology, stem cell biology, healthcare science, and quality management.
Start Year 2008
 
Description Collaboration with local SME to develop a new clinically compatible system for hESc derivations 
Organisation Intercytex
Country United Kingdom 
Sector Private 
PI Contribution ICX supplies the hDFs whilst our research group at NWESCC conducts lab based work to determine whether hDFs support human Embryonic Stem Cell growth.
Collaborator Contribution Provision of material (human dermal fibroblasts) to support the growth and derivation of human Embryonic Stem Cells.
Impact Project ongoing; Output - TSB grant to facilitate this work. See Section 3.
Start Year 2010
 
Description Miltenyi 
Organisation Miltenyi Biotec GmBH
Country Germany 
Sector Private 
PI Contribution We have submitted a large grant application to Arthritis Research Uk with Miltenyi. If successful they will contribute in kind support with cell sorting and GMP translationof our protocol for clinical therapy
Collaborator Contribution Cell sorting expertise and kits/antibodies/plates for FACs based cell sorting for enrichment of chondroprogenitors
Impact Too early
Start Year 2017
 
Description Randox 
Organisation Randox Laboratories
Country Global 
Sector Private 
PI Contribution Randox have not delivered on our collaboration to validate secretome biomarkers for eevaluation of pluripotency. We have therfor with drawn from the collaboration and moved to another collaborator.
Collaborator Contribution Collaboration was to be in antibodies and antibody related know how and to validate our biomarkers in their systems.
Impact CiC applicaion obtained but due to non delivery fdid not pursue further grant funding.
Start Year 2017
 
Description Salford University 
Organisation University of Salford
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing RNA and cDNA from human embryonic stem cells required for qPCR techniques carried out at the University of Salford, in turn qPCR will be used to investigate areas of research our lab are interested in
Collaborator Contribution The human embryonic stem cell lines were started in the university of Manchester in collaboration with St Marys hospital, developed under the supervision of Daniel Brison and Sue Kimber whom I work with as part of my research
Impact The collaboration is still in the early stages, beginning in the month of March, so at this time no results have been produced.
Start Year 2017
 
Description TEL 
Organisation Tokyo Electron and FBRI Kobe
Country Japan 
Sector Private 
PI Contribution Development of new iPSC culture an passaging method; Part of MICA consortium grant
Collaborator Contribution Sharing and development of new culture and passaging method for iPSC
Impact Grant applicaion awarded 2015 MRC Mica
Start Year 2012
 
Description Tokyo Electron Ltd, Tokyo Electron Europe 
Organisation Tokyo Electron
Country Japan 
Sector Private 
PI Contribution Developing methods for automated scaleup of stem cell manufacturing
Collaborator Contribution Providing industrial expertise and equipment
Impact not yet
Start Year 2014
 
Description UK Platform Project for Automated ESC/iPSC Culture and Differentiation 
Organisation Tokyo Electron
Country Japan 
Sector Private 
PI Contribution expertise in GMP, ESC and iPSC culture and metabolomic profiling
Collaborator Contribution provision of novel dquipment and system for pluripotent stem cell culture
Impact None yet
Start Year 2013
 
Title Generation of chondrogenic cells from human Embryonic Stem Cells 
Description This described development of a three stage culture process for obtaining cells to repair articular cartilage from hESc 
IP Reference GB1012495.6 
Protection Patent application published
Year Protection Granted 2010
Licensed No
Impact Pending
 
Title A novel method of derivation of human embryonic stem cell lines 
Description A novel method of derivation of human embryonic stem cell lines. 
Type Support Tool - For Fundamental Research
Current Stage Of Development Initial development
Year Development Stage Completed 2011
Development Status Under active development/distribution
Impact Increased success rate at deriving stem cell lines. 
 
Title HTA - 13/115/82: E-FREEZE: a randomised controlled trial evaluating the clinical and cost-effectiveness of a policy of freezing all embryos followed by thawed frozen embryo transfer, compared with a policy of fresh embryo transfer in women undergoing in-vitro fertilization 
Description HTA - 13/115/82: E-FREEZE: a randomised controlled trial evaluating the clinical and cost-effectiveness of a policy of freezing all embryos followed by thawed frozen embryo transfer, compared with a policy of fresh embryo transfer in women undergoing in-vitro fertilization 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Late clinical evaluation
Year Development Stage Completed 2016
Development Status Under active development/distribution
Clinical Trial? Yes
UKCRN/ISCTN Identifier 13/115/82
Impact HTA - 13/115/82: E-FREEZE: a randomised controlled trial evaluating the clinical and cost-effectiveness of a policy of freezing all embryos followed by thawed frozen embryo transfer, compared with a policy of fresh embryo transfer in women undergoing in-vitro fertilization 
URL http://www.isrctn.com/ISRCTN61225414
 
Title Habselect; NIHR-funded prospective clinical trial of sperm selection in ART 
Description Habselect; NIHR-funded prospective clinical trial of sperm selection in ART 
Type Therapeutic Intervention - Medical Devices
Current Stage Of Development Late clinical evaluation
Year Development Stage Completed 2016
Development Status Under active development/distribution
Clinical Trial? Yes
Impact Habselect; NIHR-funded prospective clinical trial of sperm selection in ART 
URL http://www.isrctn.com/ISRCTN99214271
 
Title Protocol for genererating chondrocyte pro-genitor cells from embryonic stem cells 
Description protocol for deriving chondrocyte progenitor cells for cartilage repair. Next stage of work funded by MRC to translate protocol to clinical grade with pre-clinical animal testing 
Type Support Tool - For Fundamental Research
Current Stage Of Development Refinement. Non-clinical
Year Development Stage Completed 2010
Development Status Under active development/distribution
Impact impacts potential not yet realised 
 
Company Name Intercytex PLC 
Description ICX 
Impact Joint running of GMP cleanrooms with ICX has allowed them to develop their products. Joint research on human feeder cells will potentially allow them to further develop markets for their products.
Website http://www.intercytex.com/
 
Description BBC Breakfast TV interview February 2018 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact BBC Breakfast TV interview February 2018 discussion growth of human eggs in the laboratory.
Year(s) Of Engagement Activity 2008,2018
 
Description BBC Health point 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact BBC Radio 4 broadcast a Health point programme featuring OA and including an interview about our work

Work aired in National media
Year(s) Of Engagement Activity 2012
 
Description Big Bang National and Regional Science Fairs 2010 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Primary Audience Schools
Results and Impact The Big Bang 2010 was held in Manchester over three days in March, attracting 22,500 people, including over 15,000 children and young people and 4,000 of their teachers, parents and guardians. Students were enthused about our research activity and indicated that they were more informed about stem cell research and interested in future placements at the University. Our interactive activities garnered significant interest and raised many interesting questions from students, parents and teachers. Consequently, the Centre was invited to participate in various science fairs/events nationwide.

Various requests for school visits were made by teachers and students and facilitated by the Centre.
Year(s) Of Engagement Activity 2010
 
Description Bollington Sci Bar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact About 60 people attended ...v good feedback

People better informed links with local industry
Year(s) Of Engagement Activity 2012
 
Description CIS talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Academics form non biological disciplines ( about 25)

Information and dissemination of ideas about research and ethics
Year(s) Of Engagement Activity 2012
 
Description CMFT Xmas lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Xmas Royal Society-style lecture for Central Manchester NHS Foundation Trust "The Stem Cell Revolution".

School visit requests
Year(s) Of Engagement Activity 2013
 
Description Can Stem Cells Mend our Broken Hearts? Manchester Town Hall 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Feedback from audiences, questions and discussion, and evaluation forms.

Increased interest in undergraduate placements with the University of Manchester, increased interest from commercial companies in product trials and collaborations with NWESCC, and increased applications from prospective PhD/MD students.
Year(s) Of Engagement Activity 2011
 
Description Cell Therapy Catapult 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact We were informing the Catapult of our activities towerds Cell therapy for Cartilage. They were advising us on most optimal way forward.

Beter informed on both sides
Year(s) Of Engagement Activity 2015
 
Description Faraday Lecture Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Faraday Public Lecture
Year(s) Of Engagement Activity 2019
 
Description Guardian newspaper article on ART child health 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Guardian newspaper article on ART child health
Year(s) Of Engagement Activity 2015
 
Description Interview on News NW 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Primary Audience Media (as a channel to the public)
Results and Impact Interview broadcast on News NW.

Informed public of opinion on patients seeking treatment abroad.
Year(s) Of Engagement Activity 2011
 
Description Interview with The Economist about male fertility 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Interview with New Scientist about male fertility, particularly the lack of focus on male reproduction compared to female
Year(s) Of Engagement Activity 2018
 
Description Invited lecture to EU Student Parliament debate on embryo research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Invited lecture to EU Student parliament debate on human embryo research including embryonic stem cell derivation, in Salford, UK
Year(s) Of Engagement Activity 2016
 
Description Knutsford sci Bar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Around 50 people various backgrounds

audience better informed change of atitude
Year(s) Of Engagement Activity 2012
 
Description Lancashire Humanists 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact 70 people attenced a public lecture on stem cell biology

Requests for other talks to Humanist groups.
Year(s) Of Engagement Activity 2013
 
Description Local SME XCellR8's "Fast Train" training workshop and exhibition on stem cell research. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Approximately 100 attendees participated in this event; activties arranged throughout the day fuelled interesting discussions and questions.

Increased awareness in stem cell research and interest in the Centre's activities from Healthcare Professionals as well as Industry representatives interested in forging future collaborations.
Year(s) Of Engagement Activity 2010
 
Description MS society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact 100 undergraduate students attended

Question about the stem cell application discussed.
Year(s) Of Engagement Activity 2012
 
Description Membership of HFEA's Information for Quality Programme 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Membership of HFEA's Information for Quality Programme
Year(s) Of Engagement Activity 2015
 
Description Membership of HFEA's Scientific and Clinical Advances Advisory Committee 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Membership of HFEA's Scientific and Clinical Advances Advisory Committee
Year(s) Of Engagement Activity Pre-2006,2006,2007,2008,
 
Description New Scientist Article on ART child health 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview for article in New Scientist on research into ART child health
Year(s) Of Engagement Activity 2016
 
Description Oxbridge Roundtable Manchester 2012 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact 50 undergraduate students attended.

Stem cell application discussed.
Year(s) Of Engagement Activity 2012
 
Description Patient information talk Manchester 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Informationa dn exchange talk with teh RUG group associated with a osteo and rheumatoid arthritis in Central Manchester Trust
Year(s) Of Engagement Activity 2019
 
Description Pluripotent Stem Cells at Cafe Scientifique 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Feedback from audiences, questions and discussion, and evaluation forms.

Increased interest in undergraduate placements with the University of Manchester, increased interest from commercial companies in product trials and collaborations with NWESCC, and increased applications from prospective PhD/MD students.
Year(s) Of Engagement Activity 2011
 
Description Progress Educational Trust Conference, London: The Robust and Responsive Embryo 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Feedback from audiences, questions and discussion, and evaluation forms.

Increased interest in undergraduate placements with the University of Manchester, increased interest from commercial companies in product trials and collaborations with NWESCC, and increased applications from prospective PhD/MD students.
Year(s) Of Engagement Activity 2011
 
Description Radio 4 interview re 'Promising' stem cell trials for blindness 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Daniel Brison interviewed and commented on news story re stem cell therapies

Raising public awareness
Year(s) Of Engagement Activity 2012
 
Description Radio 4 interview with Mark Porter 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Sue Kimber interviewed on Radio 4 Case Notes programme re stem cell therapies

Raised public awareness, led to doubled patient and GP interest in NWESCC
Year(s) Of Engagement Activity 2012
 
Description Regener8: Stem Cell Biology in Translation in the NW and Midlands 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Feedback from audiences, questions and discussion, and evaluation forms.

Increased interest in undergraduate placements with the University of Manchester, increased interest from commercial companies in product trials and collaborations with NWESCC, and increased applications from prospective PhD/MD students.
Year(s) Of Engagement Activity 2011
 
Description School 6th form talk 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Talk about Stem Cells and regenerative medicine to 5 6th form groups at local school
Year(s) Of Engagement Activity 2019
 
Description School 6th form talk 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Atalk given to 5, 6th form groups about stem cells and medicine
Year(s) Of Engagement Activity 2019
 
Description Science Media Centre press conference 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Press conference organised by SMC to discuss press release concerning submission of clinical grade embryonic stem cell lines to the UK Stem Cell Bank

Interest from media, followup stories. Followup contacts from industry resulting directly from press release.
Year(s) Of Engagement Activity 2011
 
Description So what is all this about Stem Cells, Bramhall 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Feedback from audiences, questions and discussion, and evaluation forms.

Increased interest in undergraduate placements with the University of Manchester, increased interest from commercial companies in product trials and collaborations with NWESCC, and increased applications from prospective PhD/MD students.
Year(s) Of Engagement Activity 2011
 
Description Stem Cells and Regenerative medicine from chondrocytes to kidneys 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Talk on Regenerative medicine to U3A members
Year(s) Of Engagement Activity 2018
 
Description Stockport Academy 6th form Christmas Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Schools
Results and Impact 100 students attended.

Basic stem cell knowledge was dispensed and general questions discussed.
Year(s) Of Engagement Activity 2012
 
Description TERMIS conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach International
Primary Audience Participants in your research and patient groups
Results and Impact Presented research results at the 3rd congress Termis and discussed the data with other researchers in the field of cartilage tissue engineering.

Many scientists showed interests of our research and collaboration with us.
Year(s) Of Engagement Activity 2012
 
Description UKSCN Stem Cell Roadshow: Stem Cell Treatments Where Are We? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Feedback from audiences, questions and discussion, and evaluation forms.

Increased interest in undergraduate placements with the University of Manchester, increased interest from commercial companies in product trials and collaborations with NWESCC, and increased applications from prospective PhD/MD students.
Year(s) Of Engagement Activity 2011
 
Description What is Regenerative Medicine? 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact A workshop to inform Undergraduates about what regenerative medicine is and how t can expand the possibiites for Medicine ( based on our successful workshop in 2017)
Year(s) Of Engagement Activity 2018
 
Description What is Regenerative Medicine? 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Lay type presentation explaining what the opportunities are in the sector with exemplar talks form PhD students postdoctoral researchers and research fellows
Year(s) Of Engagement Activity 2017
 
Description What is the Future for Stem Cells at Cafe Scientifique 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Feedback from audiences, questions and discussion, and evaluation forms.

Increased interest in undergraduate placements with the University of Manchester, increased interest from commercial companies in product trials and collaborations with NWESCC, and increased applications from prospective PhD/MD students.
Year(s) Of Engagement Activity 2011
 
Description Women in Science Becoming the Best 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Dissemaination of information advice and support for women's role and leadership in scince
Year(s) Of Engagement Activity 2016
 
Description cafe Scientifique 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact About 60 people attended; positive feedback much discussion

People were better informed; pro research a number of patients contacted
Year(s) Of Engagement Activity 2011