Derivation of clinical grade embryonic stem cell lines in Manchester
Lead Research Organisation:
University of Manchester
Department Name: Medical and Human Sciences
Abstract
During in vitro fertilisation (IVF) treatment many eggs and embryos fail to develop normally and are unsuitable for clinical use and routinely discarded at an early stage. Other embryos are frozen for future use. The purpose of this research is to use these eggs and embryos, with appropriate patient consent, to make human embryonic stem cells. Embryo stem cells are special cells that appear to be able to develop into all cells found in the body. As such they can be used to study early embryo development, how specialized cells form or deteriorate, to test drugs for toxicity, or for therapeutic use in the treatment of degenerative disease or tissue damage. Although many human embryonic stem cell ?lines? exist throughout the world, these are all research grade and are unlikely to be suitable for treatment of diseases. The aim of the proposed research is therefore to make new embryonic stem cells under highly regulated and clinically clean conditions, suitable for transplantation. We have new IVF and stem cell laboratories built and run to these standards and the current proposal requests funding to maintain and run these facilities in order to maximise the production of clinical grade embryonic stem cells. These new cell lines will be deposited in the UK Stem Cell Bank and any clinical treatments and commercial exploitation organised by Central Manchester NHS Trust and the University of Manchester together with the Medical Research Council.
Technical Summary
The purpose of this proposal is to derive and fully characterise 6-8 new clinical grade human embryonic stem cell (hESC) lines. It will extend the operation of the currently funded NW Embryonic Stem Cell Centre (NWESCC) in Manchester until 2011 in order to fulfil this aim. Recently established GMP cleanroom laboratory facilities funded by the MRC (IVF laboratories at St Mary?s Hospital) and the NW Development Agency (hESC laboratories at the University of Manchester) will be used. Our existing expertise in patient consenting, embryology, derivation and characterisation of hESC lines, Quality Management, and regulatory issues will be exploited and built upon. This will be extended via links and collaborations with other centres eligible for this work, including Edinburgh/Roslin Cells, Nottingham, King?s London, and Birmingham. Embryos from three sources will be used for derivation, including (i) surplus embryos from fresh IVF cycles, (ii) immature or failed-to-fertilise oocytes activated with chemical/parthenogenetic stimuli, and (iii) high quality embryos cryopreserved at the pronucleate stage. Over the last 12-18 months a large number of oocytes and embryos have been donated from the IVF programmes at St Mary?s and Manchester Fertility Services, leading to the derivation of 3 well established research grade hESC lines, RCM-1 (in collaboration with Roslin Cells, Edinburgh), Man-1 and Man-2, the first two of which have been submitted to the UK Stem Cell Bank. Clinical grade lines will be derived employing our established standard operating procedures which will be developed and refined. These make use of significant advances by NWESCC in the areas of xeno-free derivation and culture, feeder-free culture media and a GMP human fibroblast feeder cell line. Regulatory compliance will be maintained via our established Quality Management system and in conjunction with intellectual property departments at the University of Manchester and CMMC NHS Trust who will assist with commercial exploitation of GMP hESC lines in conjunction with MRC.
Organisations
- University of Manchester, Manchester, United Kingdom (Lead Research Organisation)
- Randox Laboratories (Collaboration)
- Intercytex, United Kingdom (Collaboration)
- Don Whitley Scientific Limited (Collaboration)
- Miltenyi Biotec GmBH (Collaboration)
- University of Sheffield, United Kingdom (Collaboration)
- Tokyo Electron (Collaboration)
- King's College London, United Kingdom (Collaboration)
- University of Salford, United Kingdom (Collaboration)
- Tokyo Electron and FBRI Kobe (Collaboration)
Publications

Bantounas I
(2020)
Formation of Mature Nephrons by Implantation of Human Pluripotent Stem Cell-Derived Progenitors into Mice.
in Methods in molecular biology (Clifton, N.J.)


Berneau SC
(2019)
Investigating the role of CD44 and hyaluronate in embryo-epithelial interaction using an in vitro model.
in Molecular human reproduction

Berneau SC
(2019)
Characterisation of Osteopontin in an In Vitro Model of Embryo Implantation.
in Cells

Bolton VN
(2014)
ACE consensus meeting report: culture systems.
in Human fertility (Cambridge, England)

Brison D
(2012)
ACE consensus meeting report: oocyte and embryo cryopreservation Sheffield 17.05.11.
in Human fertility (Cambridge, England)

Brison D
(2014)
Metabolic heterogeneity during preimplantation development: the missing link?
in Human Reproduction Update

Brison DR
(2016)
Professor Henry J Leese: honorary member of the European Society of Human Reproduction and Embryology.
in Human fertility (Cambridge, England)

Brison DR
(2013)
How should we assess the safety of IVF technologies?
in Reproductive biomedicine online

Camarasa M
(2009)
Naturally immortalised mouse embryonic fibroblast lines support human embryonic stem cell growth.
in Cloning and stem cells
Description | Cochrane guideline on embryo culture temperature |
Geographic Reach | Europe |
Policy Influence Type | Membership of a guideline committee |
Description | ESHRE working group on the impact of embryo culture medium on long term health |
Geographic Reach | Europe |
Policy Influence Type | Influenced training of practitioners or researchers |
Description | HFEA Information for Quality programme |
Geographic Reach | National |
Policy Influence Type | Participation in advisory committee |
Impact | acting as advisor to Human Fertilisation and Embryology Authority Information for quality programme which aims to improve regulatory oversight of the field including stem cell derivation, and improve information to patients and for delivery of clinical IVF services. |
Description | Human Fertilisation and Embryology Authority Traffic light system for add on treatments in ART |
Geographic Reach | National |
Policy Influence Type | Membership of a guideline committee |
Impact | The Human Fertilisation and Embryology Authority developed a Traffic Light system of graded evidence on the effectiveness of so-called add ons to ART treatment for infertility. |
URL | https://www.hfea.gov.uk/treatments/explore-all-treatments/treatment-add-ons/ |
Description | Influencing policy towards patenting of discoveries using hESC lines |
Geographic Reach | Europe |
Policy Influence Type | Membership of a guideline committee |
Description | Member of TERMIS Scientific Advisory Board |
Geographic Reach | National |
Policy Influence Type | Participation in a advisory committee |
Description | Membership of HFEA's Scientific and Clinical Advances committee |
Geographic Reach | National |
Policy Influence Type | Participation in a advisory committee |
Impact | Advising the HFEA on changes in regulation on ART practice, embryology, embryonic stem cell biology |
Description | National Clinical human Embryonic Stem Cell Forum |
Geographic Reach | National |
Policy Influence Type | Membership of a guideline committee |
Impact | Standardisation of requirements for clinical grade embryonic stem cell lines. Prof Brison is vice-chair of this group |
Description | Setting standards for procurement of embryonic stem cells at clinical grade |
Geographic Reach | National |
Policy Influence Type | Influenced training of practitioners or researchers |
Description | Stem Cells for Safer Medicine Panel Member |
Geographic Reach | National |
Policy Influence Type | Participation in a advisory committee |
Description | Arthritis Research UK Project Grant |
Amount | £195,453 (GBP) |
Organisation | Versus Arthritis |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 06/2010 |
End | 07/2013 |
Description | BBSRC icase studentship (with Argo) |
Amount | £110,000 (GBP) |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2014 |
End | 12/2017 |
Description | Chondrocytes from clinical grade embryonic stem cells |
Amount | £793,000 (GBP) |
Funding ID | MR/L004992/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 06/2014 |
End | 05/2017 |
Description | Diabetes UK |
Amount | £570,000 (GBP) |
Organisation | Diabetes UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 11/2015 |
End | 10/2018 |
Description | EME - EFREEZE |
Amount | £700,000 (GBP) |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 08/2015 |
End | 07/2018 |
Description | EME - HaBSelect |
Amount | £1,000,000 (GBP) |
Funding ID | EME/11/14/34 |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 01/2014 |
End | 12/2015 |
Description | EU FP7, Sybil; Systems Biology for the functional validation of genetic determinants of skeletal diseases. |
Amount | £1,180,000 (GBP) |
Funding ID | 602300 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 10/2014 |
End | 10/2018 |
Description | EpiHealth: Linking perturbed maternal environment during periconceptional development, due to diabetes, obesity or assisted reproductive technologies, and altered health during ageing. Grant agreement number: 278418 |
Amount | £385,264 (GBP) |
Funding ID | 278418 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 11/2011 |
End | 11/2013 |
Description | EpiHealthNet |
Amount | € 285,607 (EUR) |
Funding ID | 317146 |
Organisation | European Commission |
Department | Seventh Framework Programme (FP7) |
Sector | Public |
Country | European Union (EU) |
Start | 10/2013 |
End | 09/2016 |
Description | European Society for Human Reproduction and Embryology research grant scheme |
Amount | € 150,000 (EUR) |
Organisation | European Society for Human Reproduction and Embryology |
Sector | Charity/Non Profit |
Country | Belgium |
Start | 09/2019 |
End | 08/2021 |
Description | Grant funding |
Amount | £120,000 (GBP) |
Organisation | Newlife the Charity for Disabled Children |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2017 |
End | 05/2021 |
Description | Kidneys for Life |
Amount | £15,000 (GBP) |
Organisation | Kidneys for Life |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2016 |
End | 12/2016 |
Description | MRC (with Hardingham and Brison) Chondrocytes from clinical grade embryonic stem cells |
Amount | £793,000 (GBP) |
Funding ID | MR/L004992/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 06/2014 |
End | 06/2017 |
Description | MRC project grant |
Amount | £1,290,000 (GBP) |
Funding ID | MR/M017354/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 05/2015 |
End | 04/2017 |
Description | NIHR Clinical fellowship |
Amount | £270,000 (GBP) |
Organisation | National Institutes of Health (NIH) |
Sector | Public |
Country | United States |
Start | 06/2016 |
End | 05/2021 |
Description | Sparking Impact |
Amount | £10,000 (GBP) |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 07/2014 |
End | 12/2014 |
Description | Stoneygate Feehally research award |
Amount | £251,813 (GBP) |
Organisation | Kidney Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 05/2017 |
End | 04/2020 |
Description | Studentship sponsor |
Amount | £22,500 (GBP) |
Organisation | University of Manchester |
Sector | Academic/University |
Country | United Kingdom |
Start | 01/2012 |
End | 12/2014 |
Description | TSB - Expandable clinical grade feeder cells for hESc derivation |
Amount | £468,000 (GBP) |
Funding ID | 101107 |
Organisation | Innovate UK |
Sector | Public |
Country | United Kingdom |
Start | 04/2012 |
End | 06/2014 |
Description | TSB - GMP grade human dermal fibroblasts as feeders for derivation of clinically useable human ES cells |
Amount | £40,000 (GBP) |
Funding ID | 130335 |
Organisation | Innovate UK |
Sector | Public |
Country | United Kingdom |
Start | 06/2010 |
End | 03/2011 |
Description | Technology Strategy Board - Regenerative Medicine Tools & Technologies Feasibility Studies |
Amount | £49,294 (GBP) |
Organisation | Innovate UK |
Sector | Public |
Country | United Kingdom |
Start | 07/2010 |
End | 03/2011 |
Description | Toxicology programme |
Amount | £80,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2015 |
End | 12/2018 |
Description | UK national ART cohort - Population and Systems Medicine Board |
Amount | £200,000 (GBP) |
Funding ID | MR/L020335/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2014 |
End | 08/2016 |
Description | UK-China Fellowships for Excellence /Department for Business, Innovation and Skills (BIS) |
Amount | £9,600 (GBP) |
Organisation | Department for Business, Energy & Industrial Strategy |
Sector | Public |
Country | United Kingdom |
Start | 03/2011 |
End | 02/2012 |
Description | UKRMP (inter-University strategic grant) hub Safety of Stem cells |
Amount | £3,500,000 (GBP) |
Funding ID | MR/K026739/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 10/2013 |
End | 09/2018 |
Description | Wellbeing of Women |
Amount | £133,000 (GBP) |
Organisation | Royal College of Obstetricians and Gynaecologists (RCOG) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 11/2013 |
End | 10/2015 |
Title | Clinical grade human embryonic stem cell lines |
Description | Human embryonic stem cell lines which have been derived and stored at clinical grade standards suitable for use in clinical therapies. |
Type Of Material | Cell line |
Provided To Others? | No |
Impact | Not known yet |
Title | More human Embyonic Stem Cell lines, including xeno-free lines |
Description | Human embryonic stem cell lines. Research grade and clinical grade. |
Type Of Material | Cell line |
Year Produced | 2008 |
Provided To Others? | Yes |
Impact | ISCI2 project on genetic characterisation of lines (see nature Biotechnology publication). |
Title | Six Clinical grade Manchester hESC lined completed due diligence and made avialble by UKSCB |
Description | Manchester Clinical grade hESCs now registered as EUCTD compliant and launched by Stem Cell bank |
Type Of Material | Model of mechanisms or symptoms - in vitro |
Year Produced | 2017 |
Provided To Others? | Yes |
Impact | Provision at research grade lines in in 2015. Lead to several papers from Hay and Kunath groups. Now available as clinical grade though UKSCB |
Title | embryo cDNAs |
Description | amplified cDNAs from individual human embryos suitable for gene expression analysis |
Type Of Material | Database/Collection of Data/Biological Samples |
Year Produced | 2010 |
Provided To Others? | Yes |
Impact | Sneddon et al 2012 paper |
Title | embryo microarray data |
Description | gene expression data from single human embryos available for bioinformatic analysis |
Type Of Material | Database/Collection of Data/Biological Samples |
Year Produced | 2011 |
Provided To Others? | Yes |
Impact | publications in preparation |
Title | human Embryonic Stem Cell lines |
Description | human Embryonic Stem Cell lines |
Type Of Material | Cell line |
Year Produced | 2010 |
Provided To Others? | Yes |
Impact | Results not yet known. |
Description | Collaboration with Don Whitley Scientific |
Organisation | Don Whitley Scientific Limited |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | To develop and evaluate better ways of genrating good manufacturing (clinical) standrd high quality induced pluripotent stem cells at low cost using an environmental work station |
Collaborator Contribution | DWS have a work staion whihc h they will upgrade a redesign for controlled atmosphere working. Applied to Innovate for fudning but narrowly missed |
Impact | innovate grant...will put in for CIC and pos P2D |
Start Year | 2015 |
Description | Collaboration with ISCI2 |
Organisation | University of Sheffield |
Department | Department of Biomedical Science |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Dervied and characterised novel stem cell lines in Manchester and submitted these to international initiative for genetic characterisation. |
Collaborator Contribution | Derived and characterised novel stem cell lines in Manchester and submitted these to international initiative for genetic characterisation. |
Impact | Paper in press in Nature Biotechnology describing genetic characterisation of 127 embryonic stem cell lines. Disciplines covered are stem cell biology, embryology and genetics. |
Start Year | 2009 |
Description | Collaboration with Intercytex for development of GMP grade human dermal fibroblasts as feeders for derivation of clinically useable human ES cells |
Organisation | Intercytex |
Country | United Kingdom |
Sector | Private |
PI Contribution | Development of GMP grade human dermal fibroblasts as feeders for derivation of clinically useable human ES cells |
Collaborator Contribution | Development of GMP grade human dermal fibroblasts as feeders for derivation of clinically useable human ES cells |
Impact | Grant income of £40,000; collaboration with Intercytex to jointly run GMP laboratories; and successful application to MHRA for product manufacturing licence. This collaboration covers the following disiplines: embryology, stem cell biology, quality management, wound healing. |
Start Year | 2010 |
Description | Collaboration with Kings College, University of London |
Organisation | King's College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Sharing bext practice with King's via regular meetings. |
Collaborator Contribution | Sharing bext practice with King's via regular meetings. |
Impact | Collaboration has resulted in clinical grade stem cell lines ready for submission to UKSCB and a Science Media Centre event has been organised to publicise submission of clinical grade stem cell lines to UK Stem Cell Bank. Disciplines covered are embryology, stem cell biology, healthcare science, and quality management. |
Start Year | 2008 |
Description | Collaboration with local SME to develop a new clinically compatible system for hESc derivations |
Organisation | Intercytex |
Country | United Kingdom |
Sector | Private |
PI Contribution | ICX supplies the hDFs whilst our research group at NWESCC conducts lab based work to determine whether hDFs support human Embryonic Stem Cell growth. |
Collaborator Contribution | Provision of material (human dermal fibroblasts) to support the growth and derivation of human Embryonic Stem Cells. |
Impact | Project ongoing; Output - TSB grant to facilitate this work. See Section 3. |
Start Year | 2010 |
Description | Miltenyi |
Organisation | Miltenyi Biotec GmBH |
Country | Germany |
Sector | Private |
PI Contribution | We have submitted a large grant application to Arthritis Research Uk with Miltenyi. If successful they will contribute in kind support with cell sorting and GMP translationof our protocol for clinical therapy |
Collaborator Contribution | Cell sorting expertise and kits/antibodies/plates for FACs based cell sorting for enrichment of chondroprogenitors |
Impact | Too early |
Start Year | 2017 |
Description | Randox |
Organisation | Randox Laboratories |
Country | Global |
Sector | Private |
PI Contribution | Randox have not delivered on our collaboration to validate secretome biomarkers for eevaluation of pluripotency. We have therfor with drawn from the collaboration and moved to another collaborator. |
Collaborator Contribution | Collaboration was to be in antibodies and antibody related know how and to validate our biomarkers in their systems. |
Impact | CiC applicaion obtained but due to non delivery fdid not pursue further grant funding. |
Start Year | 2017 |
Description | Salford University |
Organisation | University of Salford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Providing RNA and cDNA from human embryonic stem cells required for qPCR techniques carried out at the University of Salford, in turn qPCR will be used to investigate areas of research our lab are interested in |
Collaborator Contribution | The human embryonic stem cell lines were started in the university of Manchester in collaboration with St Marys hospital, developed under the supervision of Daniel Brison and Sue Kimber whom I work with as part of my research |
Impact | The collaboration is still in the early stages, beginning in the month of March, so at this time no results have been produced. |
Start Year | 2017 |
Description | TEL |
Organisation | Tokyo Electron and FBRI Kobe |
Country | Japan |
Sector | Private |
PI Contribution | Development of new iPSC culture an passaging method; Part of MICA consortium grant |
Collaborator Contribution | Sharing and development of new culture and passaging method for iPSC |
Impact | Grant applicaion awarded 2015 MRC Mica |
Start Year | 2012 |
Description | Tokyo Electron Ltd, Tokyo Electron Europe |
Organisation | Tokyo Electron |
Country | Japan |
Sector | Private |
PI Contribution | Developing methods for automated scaleup of stem cell manufacturing |
Collaborator Contribution | Providing industrial expertise and equipment |
Impact | not yet |
Start Year | 2014 |
Description | UK Platform Project for Automated ESC/iPSC Culture and Differentiation |
Organisation | Tokyo Electron |
Country | Japan |
Sector | Private |
PI Contribution | expertise in GMP, ESC and iPSC culture and metabolomic profiling |
Collaborator Contribution | provision of novel dquipment and system for pluripotent stem cell culture |
Impact | None yet |
Start Year | 2013 |
Title | Generation of chondrogenic cells from human Embryonic Stem Cells |
Description | This described development of a three stage culture process for obtaining cells to repair articular cartilage from hESc |
IP Reference | GB1012495.6 |
Protection | Patent application published |
Year Protection Granted | 2010 |
Licensed | No |
Impact | Pending |
Title | A novel method of derivation of human embryonic stem cell lines |
Description | A novel method of derivation of human embryonic stem cell lines. |
Type | Support Tool - For Fundamental Research |
Current Stage Of Development | Initial development |
Year Development Stage Completed | 2011 |
Development Status | Under active development/distribution |
Impact | Increased success rate at deriving stem cell lines. |
Title | HTA - 13/115/82: E-FREEZE: a randomised controlled trial evaluating the clinical and cost-effectiveness of a policy of freezing all embryos followed by thawed frozen embryo transfer, compared with a policy of fresh embryo transfer in women undergoing in-vitro fertilization |
Description | HTA - 13/115/82: E-FREEZE: a randomised controlled trial evaluating the clinical and cost-effectiveness of a policy of freezing all embryos followed by thawed frozen embryo transfer, compared with a policy of fresh embryo transfer in women undergoing in-vitro fertilization |
Type | Therapeutic Intervention - Medical Devices |
Current Stage Of Development | Late clinical evaluation |
Year Development Stage Completed | 2016 |
Development Status | Under active development/distribution |
Clinical Trial? | Yes |
UKCRN/ISCTN Identifier | 13/115/82 |
Impact | HTA - 13/115/82: E-FREEZE: a randomised controlled trial evaluating the clinical and cost-effectiveness of a policy of freezing all embryos followed by thawed frozen embryo transfer, compared with a policy of fresh embryo transfer in women undergoing in-vitro fertilization |
URL | http://www.isrctn.com/ISRCTN61225414 |
Title | Habselect; NIHR-funded prospective clinical trial of sperm selection in ART |
Description | Habselect; NIHR-funded prospective clinical trial of sperm selection in ART |
Type | Therapeutic Intervention - Medical Devices |
Current Stage Of Development | Late clinical evaluation |
Year Development Stage Completed | 2016 |
Development Status | Under active development/distribution |
Clinical Trial? | Yes |
Impact | Habselect; NIHR-funded prospective clinical trial of sperm selection in ART |
URL | http://www.isrctn.com/ISRCTN99214271 |
Title | Protocol for genererating chondrocyte pro-genitor cells from embryonic stem cells |
Description | protocol for deriving chondrocyte progenitor cells for cartilage repair. Next stage of work funded by MRC to translate protocol to clinical grade with pre-clinical animal testing |
Type | Support Tool - For Fundamental Research |
Current Stage Of Development | Refinement. Non-clinical |
Year Development Stage Completed | 2010 |
Development Status | Under active development/distribution |
Impact | impacts potential not yet realised |
Company Name | Intercytex PLC |
Description | ICX |
Impact | Joint running of GMP cleanrooms with ICX has allowed them to develop their products. Joint research on human feeder cells will potentially allow them to further develop markets for their products. |
Website | http://www.intercytex.com/ |
Description | BBC Breakfast TV interview February 2018 |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | BBC Breakfast TV interview February 2018 discussion growth of human eggs in the laboratory. |
Year(s) Of Engagement Activity | 2008,2018 |
Description | BBC Health point |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | BBC Radio 4 broadcast a Health point programme featuring OA and including an interview about our work Work aired in National media |
Year(s) Of Engagement Activity | 2012 |
Description | Big Bang National and Regional Science Fairs 2010 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | Yes |
Primary Audience | Schools |
Results and Impact | The Big Bang 2010 was held in Manchester over three days in March, attracting 22,500 people, including over 15,000 children and young people and 4,000 of their teachers, parents and guardians. Students were enthused about our research activity and indicated that they were more informed about stem cell research and interested in future placements at the University. Our interactive activities garnered significant interest and raised many interesting questions from students, parents and teachers. Consequently, the Centre was invited to participate in various science fairs/events nationwide. Various requests for school visits were made by teachers and students and facilitated by the Centre. |
Year(s) Of Engagement Activity | 2010 |
Description | Bollington Sci Bar |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | About 60 people attended ...v good feedback People better informed links with local industry |
Year(s) Of Engagement Activity | 2012 |
Description | CIS talk |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | Local |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Academics form non biological disciplines ( about 25) Information and dissemination of ideas about research and ethics |
Year(s) Of Engagement Activity | 2012 |
Description | CMFT Xmas lecture |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Xmas Royal Society-style lecture for Central Manchester NHS Foundation Trust "The Stem Cell Revolution". School visit requests |
Year(s) Of Engagement Activity | 2013 |
Description | Can Stem Cells Mend our Broken Hearts? Manchester Town Hall |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Primary Audience | Public/other audiences |
Results and Impact | Feedback from audiences, questions and discussion, and evaluation forms. Increased interest in undergraduate placements with the University of Manchester, increased interest from commercial companies in product trials and collaborations with NWESCC, and increased applications from prospective PhD/MD students. |
Year(s) Of Engagement Activity | 2011 |
Description | Cell Therapy Catapult |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | We were informing the Catapult of our activities towerds Cell therapy for Cartilage. They were advising us on most optimal way forward. Beter informed on both sides |
Year(s) Of Engagement Activity | 2015 |
Description | Faraday Lecture Cambridge |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Faraday Public Lecture |
Year(s) Of Engagement Activity | 2019 |
Description | Guardian newspaper article on ART child health |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Guardian newspaper article on ART child health |
Year(s) Of Engagement Activity | 2015 |
Description | Interview on News NW |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Interview broadcast on News NW. Informed public of opinion on patients seeking treatment abroad. |
Year(s) Of Engagement Activity | 2011 |
Description | Interview with The Economist about male fertility |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Interview with New Scientist about male fertility, particularly the lack of focus on male reproduction compared to female |
Year(s) Of Engagement Activity | 2018 |
Description | Invited lecture to EU Student Parliament debate on embryo research |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Undergraduate students |
Results and Impact | Invited lecture to EU Student parliament debate on human embryo research including embryonic stem cell derivation, in Salford, UK |
Year(s) Of Engagement Activity | 2016 |
Description | Knutsford sci Bar |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Around 50 people various backgrounds audience better informed change of atitude |
Year(s) Of Engagement Activity | 2012 |
Description | Lancashire Humanists |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | 70 people attenced a public lecture on stem cell biology Requests for other talks to Humanist groups. |
Year(s) Of Engagement Activity | 2013 |
Description | Local SME XCellR8's "Fast Train" training workshop and exhibition on stem cell research. |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Primary Audience | Health professionals |
Results and Impact | Approximately 100 attendees participated in this event; activties arranged throughout the day fuelled interesting discussions and questions. Increased awareness in stem cell research and interest in the Centre's activities from Healthcare Professionals as well as Industry representatives interested in forging future collaborations. |
Year(s) Of Engagement Activity | 2010 |
Description | MS society |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | Local |
Primary Audience | Undergraduate students |
Results and Impact | 100 undergraduate students attended Question about the stem cell application discussed. |
Year(s) Of Engagement Activity | 2012 |
Description | Membership of HFEA's Information for Quality Programme |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Membership of HFEA's Information for Quality Programme |
Year(s) Of Engagement Activity | 2015 |
Description | Membership of HFEA's Scientific and Clinical Advances Advisory Committee |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Membership of HFEA's Scientific and Clinical Advances Advisory Committee |
Year(s) Of Engagement Activity | Pre-2006,2006,2007,2008,2009,2010,2011,2012,2013,2014,2015,2016 |
Description | New Scientist Article on ART child health |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Interview for article in New Scientist on research into ART child health |
Year(s) Of Engagement Activity | 2016 |
Description | Oxbridge Roundtable Manchester 2012 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | Regional |
Primary Audience | Postgraduate students |
Results and Impact | 50 undergraduate students attended. Stem cell application discussed. |
Year(s) Of Engagement Activity | 2012 |
Description | Patient information talk Manchester |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Informationa dn exchange talk with teh RUG group associated with a osteo and rheumatoid arthritis in Central Manchester Trust |
Year(s) Of Engagement Activity | 2019 |
Description | Pluripotent Stem Cells at Cafe Scientifique |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Primary Audience | Public/other audiences |
Results and Impact | Feedback from audiences, questions and discussion, and evaluation forms. Increased interest in undergraduate placements with the University of Manchester, increased interest from commercial companies in product trials and collaborations with NWESCC, and increased applications from prospective PhD/MD students. |
Year(s) Of Engagement Activity | 2011 |
Description | Progress Educational Trust Conference, London: The Robust and Responsive Embryo |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Primary Audience | Public/other audiences |
Results and Impact | Feedback from audiences, questions and discussion, and evaluation forms. Increased interest in undergraduate placements with the University of Manchester, increased interest from commercial companies in product trials and collaborations with NWESCC, and increased applications from prospective PhD/MD students. |
Year(s) Of Engagement Activity | 2011 |
Description | Radio 4 interview re 'Promising' stem cell trials for blindness |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Daniel Brison interviewed and commented on news story re stem cell therapies Raising public awareness |
Year(s) Of Engagement Activity | 2012 |
Description | Radio 4 interview with Mark Porter |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Sue Kimber interviewed on Radio 4 Case Notes programme re stem cell therapies Raised public awareness, led to doubled patient and GP interest in NWESCC |
Year(s) Of Engagement Activity | 2012 |
Description | Regener8: Stem Cell Biology in Translation in the NW and Midlands |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Primary Audience | Public/other audiences |
Results and Impact | Feedback from audiences, questions and discussion, and evaluation forms. Increased interest in undergraduate placements with the University of Manchester, increased interest from commercial companies in product trials and collaborations with NWESCC, and increased applications from prospective PhD/MD students. |
Year(s) Of Engagement Activity | 2011 |
Description | School 6th form talk 2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Talk about Stem Cells and regenerative medicine to 5 6th form groups at local school |
Year(s) Of Engagement Activity | 2019 |
Description | School 6th form talk 2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Atalk given to 5, 6th form groups about stem cells and medicine |
Year(s) Of Engagement Activity | 2019 |
Description | Science Media Centre press conference |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | Yes |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Press conference organised by SMC to discuss press release concerning submission of clinical grade embryonic stem cell lines to the UK Stem Cell Bank Interest from media, followup stories. Followup contacts from industry resulting directly from press release. |
Year(s) Of Engagement Activity | 2011 |
Description | So what is all this about Stem Cells, Bramhall |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Primary Audience | Public/other audiences |
Results and Impact | Feedback from audiences, questions and discussion, and evaluation forms. Increased interest in undergraduate placements with the University of Manchester, increased interest from commercial companies in product trials and collaborations with NWESCC, and increased applications from prospective PhD/MD students. |
Year(s) Of Engagement Activity | 2011 |
Description | Stem Cells and Regenerative medicine from chondrocytes to kidneys |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Talk on Regenerative medicine to U3A members |
Year(s) Of Engagement Activity | 2018 |
Description | Stockport Academy 6th form Christmas Symposium |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | 100 students attended. Basic stem cell knowledge was dispensed and general questions discussed. |
Year(s) Of Engagement Activity | 2012 |
Description | TERMIS conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Type Of Presentation | Poster Presentation |
Geographic Reach | International |
Primary Audience | Participants in your research and patient groups |
Results and Impact | Presented research results at the 3rd congress Termis and discussed the data with other researchers in the field of cartilage tissue engineering. Many scientists showed interests of our research and collaboration with us. |
Year(s) Of Engagement Activity | 2012 |
Description | UKSCN Stem Cell Roadshow: Stem Cell Treatments Where Are We? |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Primary Audience | Public/other audiences |
Results and Impact | Feedback from audiences, questions and discussion, and evaluation forms. Increased interest in undergraduate placements with the University of Manchester, increased interest from commercial companies in product trials and collaborations with NWESCC, and increased applications from prospective PhD/MD students. |
Year(s) Of Engagement Activity | 2011 |
Description | What is Regenerative Medicine? |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Undergraduate students |
Results and Impact | Lay type presentation explaining what the opportunities are in the sector with exemplar talks form PhD students postdoctoral researchers and research fellows |
Year(s) Of Engagement Activity | 2017 |
Description | What is Regenerative Medicine? |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Undergraduate students |
Results and Impact | A workshop to inform Undergraduates about what regenerative medicine is and how t can expand the possibiites for Medicine ( based on our successful workshop in 2017) |
Year(s) Of Engagement Activity | 2018 |
Description | What is the Future for Stem Cells at Cafe Scientifique |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Primary Audience | Public/other audiences |
Results and Impact | Feedback from audiences, questions and discussion, and evaluation forms. Increased interest in undergraduate placements with the University of Manchester, increased interest from commercial companies in product trials and collaborations with NWESCC, and increased applications from prospective PhD/MD students. |
Year(s) Of Engagement Activity | 2011 |
Description | Women in Science Becoming the Best |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Dissemaination of information advice and support for women's role and leadership in scince |
Year(s) Of Engagement Activity | 2016 |
Description | cafe Scientifique |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Type Of Presentation | Keynote/Invited Speaker |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | About 60 people attended; positive feedback much discussion People were better informed; pro research a number of patients contacted |
Year(s) Of Engagement Activity | 2011 |