UK Collaborative Trial of Ovarian Cancer Screening
Lead Research Organisation:
University College London
Department Name: Maternal & Fetal Medicine
Abstract
UKCTOCS aims to assess whether ovarian cancer screening will save lives while comprehensively evaluating the screening strategies available, the worry and complications associated with screening and ensuing surgery, compliance and the potential resource implications for the NHS. Women aged 50-74 in 13 regions in the UK were invited to take part. The 202,638 women who joined the study were randomly allocated to an observation (control) group or screening with transvaginal ultrasound (USS)for 6 years or screening with a blood test called CA125 for 6 years. All women are being followed up by postal questionnaire and through the Office for National Statistics to establish whether or not they develop ovarian cancer or die of the disease. Screening is ongoing and the study has met all its targets on recruitment, retention and follow up. Currently each woman is in the trial for 7 years from randomisation and the trial will be complete in 2012. Hoever, it is now clear that there are less deaths from ovarian cancer than expected in the women in the control group who have not been screened. As a result of thos healthy volunteer effect the trial needs to be extended to obtain a clear answer to the question - Can ovarian cancer screening save lives? The best approach will be to extend screening until 2011 and follow up everyone until 2014.
Technical Summary
UKCTOCS is a RCT to assess impact of screening on ovarian cancer mortality while evaluating performance characteristics of screening, physical and psychological morbidity, compliance and resource implications. Women aged 50-74 were invited from 27 Primary Care Trusts adjoining 13 trial centres. Women who accepted were invited to recruitment and 202,638 were randomised to an observation (control) group or 6 annual screens with transvaginal ultrasound (USS)or serum CA125 (M)in a 2:1:1 ratio. All women are being followed up by postal questionnaire and ?flagging? through the Office for National Statistics. Screening is ongoing and the study has met all its targets for recruitment, retention and follow up. Currently each woman is in the trial for 7 years from randomisation and the trial will be complete in 2012. It has now become clear that the number of age adjusted observed deaths (OD) in UKCTOCS participants is significantly reduced compared to expected deaths (ED), based on ONS mortality statistics. The overall Standardised Mortality Ratio (SMR - ratio of OD/ED expressed as a percentage) is 31.6 and for ovarian cancer is estimated at 65. As a result of this healthy volunteer effect, there will be a shortfall in power. An extension is therefore requested to compensate for this effect. Various options have been explored to increase events in the control arm. The favoured option based on cost and time to trial completion is extending trial participation to the end of 2014 with all women in the screened arm undergoing screening till end of 2011.
Organisations
- University College London, United Kingdom (Collaboration, Lead Research Organisation)
- Unlisted (Collaboration)
- University of Copenhagen, Denmark (Collaboration)
- University of Liverpool, United Kingdom (Collaboration)
- Fred Hutchinson Cancer Research Center (FHCRC) (Collaboration)
- University of Texas at San Antonio, United States (Collaboration)
- University of Pittsburgh (Collaboration)
- University of Manchester, Manchester, United Kingdom (Collaboration)
- Becton, Dickinson and Company (Collaboration)
Publications
Allen P. L.
(2010)
Prospective study of symptoms of ovarian cancer in postmenopausal women
Anjum S
(2014)
A BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival.
in Genome medicine
Barrett J
(2014)
Psychological morbidity associated with ovarian cancer screening: results from more than 23,000 women in the randomised trial of ovarian cancer screening (UKCTOCS).
in BJOG : an international journal of obstetrics and gynaecology
Blyuss O
(2015)
Serial Patterns of Ovarian Cancer Biomarkers in a Prediagnosis Longitudinal Dataset.
in BioMed research international
Borges M
(2017)
Metabolic Profiling of Adiponectin Levels in Adults Mendelian Randomization Analysis
in Circulation: Cardiovascular Genetics
Borges MC
(2020)
Circulating Fatty Acids and Risk of Coronary Heart Disease and Stroke: Individual Participant Data Meta-Analysis in Up to 16 126 Participants.
in Journal of the American Heart Association
Burford B
(2013)
Autoantibodies to MUC1 glycopeptides cannot be used as a screening assay for early detection of breast, ovarian, lung or pancreatic cancer.
in British journal of cancer
| Title | Creation of artwork for thank you card for UKCTOCS volunteers |
| Description | A painting of a primary ovarian follicle was created by a commissioned artist (Dr Lizzie Burns). The image of painting was digitized so that each dot represented 8 women participants in the trial. This digitized image was then used on the front of a card that was posted at the end of the screening period to all the the UKCTOCS volunteers to thank them for their participation in the trial. mailin was performed in collaboration with the charity, The Eve Appeal. The package also contained information about the trial and what was to happen during the follow-up period of UKCTOCS. |
| Type Of Art | Artwork |
| Year Produced | 2012 |
| Impact | Approximately 30,000 replies were received back from the women within three weeks of mailing- expressing huge appreciation of the trial and what its was trying to achieve, that the team had 'remembered' the volunteers. Many volunteers touched by the gesture. In women where a cancer had been detected, felt that the trial had saved their lives. Added benefit was that the The Eve Appeal database of donors was increased . |
| URL | https://www.ucl.ac.uk/instituteforwomenshealth/news/oldnewsletters/new-letters-tabbed-box/2012/2012m... |
| Guideline Title | The UK NSC recommendation on Ovarian cancer screening in women |
| Description | Ovarian Cancer Screening Guideline |
| Geographic Reach | National |
| Policy Influence Type | Citation in clinical guidelines |
| Guideline Title | Screening for Ovarian Cancer US Preventive Services Task Force Recommendation Statement |
| Description | Ovarian Cancer Screening Guideline |
| Geographic Reach | North America |
| Policy Influence Type | Citation in clinical guidelines |
| URL | https://jamanetwork.com/journals/jama/fullarticle/2672638 |
| Guideline Title | Testing for ovarian cancer in asymptomatic women |
| Description | Ovarian Cancer Screening Guideline |
| Geographic Reach | Australia |
| Policy Influence Type | Citation in clinical guidelines |
| URL | https://canceraustralia.gov.au/publications-and-resources/position-statements/testing-ovarian-cancer... |
| Guideline Title | Guidelines for preventive activities in general practice The Red Book 9.6 Ovarian Cancer |
| Description | Ovarian Cancer Screening Guideline |
| Geographic Reach | Australia |
| Policy Influence Type | Citation in clinical guidelines |
| URL | https://www.racgp.org.au/clinical-resources/clinical-guidelines/key-racgp-guidelines/view-all-racgp-... |
| Description | Ovarian cancer awareness consultation |
| Geographic Reach | National |
| Policy Influence Type | Participation in a national consultation |
| Description | Training of UKCTOCS sonographers |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | CRUK BIDD Project Grant |
| Amount | £185,000 (GBP) |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2011 |
| End | 03/2013 |
| Description | CRUK TRICC Project Grant |
| Amount | £145,154 (GBP) |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2009 |
| End | 11/2010 |
| Description | DH Service Support Costs UKCTOCS |
| Amount | £6,000,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| End | 06/2015 |
| Description | EU FP7 |
| Amount | £90,000 (GBP) |
| Funding ID | HEALTH-F5-2012-305428 |
| Organisation | European Commission |
| Department | Seventh Framework Programme (FP7) |
| Sector | Public |
| Country | European Union (EU) |
| Start | |
| Description | MRC Clinical Trial Grant (UKCTOCS Extension of Screening) |
| Amount | £2,303,175 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2010 |
| End | 08/2015 |
| Description | MRC Training Grant: Industrial Case Award |
| Amount | £118,230 (GBP) |
| Funding ID | MR/J006718/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2012 |
| End | 08/2016 |
| Description | NIHR UCLH Biomedical Research Centre Cancer Programme Funding |
| Amount | £100,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2014 |
| End | 05/2016 |
| Description | PRC Programme Grant -CRUK component |
| Amount | £1,620,000 (GBP) |
| Funding ID | C1005/A12677 |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2011 |
| End | 08/2016 |
| Description | PRC Programme grant - EVE Appeal component |
| Amount | £1,641,890 (GBP) |
| Organisation | The Eve Appeal |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2011 |
| End | 08/2016 |
| Description | Pancreatic Cancer UK Project grant |
| Amount | £149,391 (GBP) |
| Organisation | Pancreatic Cancer UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2011 |
| End | 07/2013 |
| Description | Pancreatic cancer UK Pump priming grant |
| Amount | £10,000 (GBP) |
| Organisation | Pancreatic Society of Great Britain and Ireland (PanSoc) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Programme of Translational Research in Gynaecological cancer (UCL & Special Trustees UCLH) |
| Amount | £1,100,000 (GBP) |
| Organisation | University College London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | UCL/UCLH CBRC New Initiatives |
| Amount | £35,647 (GBP) |
| Organisation | National Institute for Health Research |
| Department | UCLH/UCL Biomedical Research Centre |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2009 |
| End | 01/2010 |
| Description | UCLH/UCL Comprehensive Biomedical Research Centre (Epigenetic and Genetic analysis in UKCTOCS) |
| Amount | £800,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | UCLH/UCL Biomedical Research Centre |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2009 |
| End | 12/2014 |
| Title | A database of serum peptide identifications |
| Description | The identities of low-molecular weight serum peptides found using our profiling platform has been determined and a database of these assembled for reference in future profiling studies |
| Type Of Material | Biological samples |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | Publication of the data and use in other biomarker discovery projects |
| Title | A reproducible platform for serum peptide profiling |
| Description | A platform incorporating robotic extraction of peptides from serum on magnetic beads and sample spotting linked to automated MALDI-TOF MS data acquisition was developed for high-throughput profiling of low-mass polypeptides in the serum of clinical sample sets |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | The platform has been applied on mutliple biomarker discovery projects using serum from case control collections and pre-diagnosis samples from UKCTOCS |
| Title | Cost recovery tool for biobanks |
| Description | We have developed a cost recovery tool to calculate costs for sharing of data and samples in a transparent and reproducible manner |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | We also use the tool with regard to our other bioresources and it has helped with cost recovery and sustainibility. |
| Title | UKCTOCS trial management system |
| Description | Database system that assists in running of the trial. |
| Type Of Material | Biological samples |
| Provided To Others? | No |
| Impact | Streamlined running of all aspects of UKCTOCS. |
| Title | UKLWC |
| Description | UK Longitudinal Women's Cohort is the bioresource created during the course of UKCTOCS. With over 202,000 women, 5.5 million donated serum samples and over 14 years follow-up through electronic health record linkage, this complements UK Biobank. |
| Type Of Material | Biological samples |
| Year Produced | 2010 |
| Provided To Others? | Yes |
| Impact | A number of publications mainly focused on early detection biomarkers |
| URL | https://www.ucl.ac.uk/womens-health/research/womens-cancer/gynaecological-cancer-research-centre/ukl... |
| Title | Ultrasound Record Archive |
| Description | We are databasing static ultrasound images collected during the UKCTOCS trial which will serve as an electronic source for review and management of women on the trial. In addition it enables training and refinement of techniques for assessing the ultrasound images. There is huge potential also for pursuing future research in imaging postmenopausal ovaries in health and in cancer. Currently have 255,472 archived TVS examinations. |
| Type Of Material | Biological samples |
| Provided To Others? | No |
| Impact | The database is currently incomplete but represents a major resource for investigation and training. The major benefit of this electronic resource is ease of access and rapidity to volunteer scanning results. It also provides a means for checking the quality of ultrasonography in UKCTOCS. In terms of research efforts it represent a significant resource for a variety of analyses, including assessment of ultrasound findings in malignant lesions in ovarian and other gynaecological cancers. The URA also has the potential to help refine and set standards for ultrasound image analysis. |
| Description | Biomarker assessment in preclinical samples from UKCTOCS |
| Organisation | Fred Hutchinson Cancer Research Center (FHCRC) |
| Department | Molecular Diagnostics Program (FHCRC) |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Providing samples and data from controls and ovarian cancer cases |
| Collaborator Contribution | Access to novel biomarker assays |
| Impact | Bilateral partnership - Agreement, Ethics and MTA in place. |
| Start Year | 2010 |
| Description | Discovery of biomarkers of biliary tract and pancreatic cancer |
| Organisation | University College London |
| Department | Institute of Liver and Digestive Health |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Proteomic profiling of clinical and control samples of biliary tract cancer and training of a PhD student. Proteomic profiling of pre-diagnosis and matched healthy control serum samples and case controls in a pancreatic cancer biomarker discovery and validation project. |
| Collaborator Contribution | Provision of expertise in pancreatic and biliary tract cancers and access to clinical samples for biomarker discoveryAccess to case control samples of benign pancreatic disease and pancreatic cancer for biomarker discovery |
| Impact | Award of PancSoc GB&I pump priming grant to validate reported markers of pancreatic cancer in prediagnosis and control samples. Award of CRUK TRICC pilot grant, CRUK BIDD Project grant and Pancreatic cancer UK grant aimed at discovery of serum biomarkers of pancreatic cancer. Identification of promising candidate biomarkers and one publications accepted and another submitted. |
| Start Year | 2008 |
| Description | Discovery of biomarkers of biliary tract and pancreatic cancer |
| Organisation | University of Liverpool |
| Department | Medicine and Surgery |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Proteomic profiling of clinical and control samples of biliary tract cancer and training of a PhD student. Proteomic profiling of pre-diagnosis and matched healthy control serum samples and case controls in a pancreatic cancer biomarker discovery and validation project. |
| Collaborator Contribution | Provision of expertise in pancreatic and biliary tract cancers and access to clinical samples for biomarker discoveryAccess to case control samples of benign pancreatic disease and pancreatic cancer for biomarker discovery |
| Impact | Award of PancSoc GB&I pump priming grant to validate reported markers of pancreatic cancer in prediagnosis and control samples. Award of CRUK TRICC pilot grant, CRUK BIDD Project grant and Pancreatic cancer UK grant aimed at discovery of serum biomarkers of pancreatic cancer. Identification of promising candidate biomarkers and one publications accepted and another submitted. |
| Start Year | 2008 |
| Description | Discovery of biomarkers of pancreatobiliary disease |
| Organisation | University College London |
| Department | Institute of Liver and Digestive Health |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Samples from UKCTOCS have been provided to collaborators for biomarker testing and discovery using complementary techniques to those applied at UCL |
| Collaborator Contribution | Provision of expertise in pancreatic and biliary tract cancers and access to clinical samples for biomarker discoveryProvision of expertise in pancreatic cancer and access to additional case control serum samples relevant to biomarker discovery |
| Impact | Award of PancSoc GB&I pump priming grant to validate reported markers of pancreatic cancer in prediagnosis and control samples. Award of CRUK TRICC pilot grant, CRUK BIDD Project grant and Pancreatic cancer UK grant aimed at discovery of serum biomarkers of pancreatic cancer. Identification of promising candidate biomarkers with one publication accepted and another submitted. |
| Start Year | 2008 |
| Description | Discovery of biomarkers of pancreatobiliary disease |
| Organisation | University of Liverpool |
| Department | Department of Molecular and Clinical Cancer Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Samples from UKCTOCS have been provided to collaborators for biomarker testing and discovery using complementary techniques to those applied at UCL |
| Collaborator Contribution | Provision of expertise in pancreatic and biliary tract cancers and access to clinical samples for biomarker discoveryProvision of expertise in pancreatic cancer and access to additional case control serum samples relevant to biomarker discovery |
| Impact | Award of PancSoc GB&I pump priming grant to validate reported markers of pancreatic cancer in prediagnosis and control samples. Award of CRUK TRICC pilot grant, CRUK BIDD Project grant and Pancreatic cancer UK grant aimed at discovery of serum biomarkers of pancreatic cancer. Identification of promising candidate biomarkers with one publication accepted and another submitted. |
| Start Year | 2008 |
| Description | Hormonal Profile in Breast cancer |
| Organisation | University College London |
| Department | UCL Cancer Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Samples and data from UKCTOCS volunteers who developed breast cancer |
| Collaborator Contribution | Expertise in Breast cancer |
| Impact | A PhD awarded and two publications: Fourkala EO et al Endocrine-related cancer. 2012 Apr;19(2):137-47. Fourkala EO et al Br J Cancer. 2012 Jun 5;106(12):1910-6. |
| Start Year | 2008 |
| Description | MRC Proteomics biomarker discovery |
| Organisation | University College London |
| Department | UCL Cancer Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Use of UKCTOCS samples for the biomarker discovery project. |
| Impact | MRC Grant for proteomic discovery of biomarkers for ovarian cancer.Project complete. Details of publications are provided in the publications section. |
| Start Year | 2006 |
| Description | Multianalyte assay for early diagnosis of ovarian cancer |
| Organisation | University of Pittsburgh |
| Department | School of Medicine Pittsburgh |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Input into the study design and data interpretation. Preclinical samples and data from ovarian cancer cases and controls |
| Collaborator Contribution | Enabling assessment of serum biomarkers in multiplex system. |
| Impact | Project ongoing - intial sample sets have been shipped to our Collaborators and are being assayed. Results from sample testing are pending. |
| Start Year | 2007 |
| Description | Pilot study-Ovarian Cancer Biomarker discovery |
| Organisation | Becton, Dickinson and Company |
| Country | United States |
| Sector | Private |
| PI Contribution | Provision of serum and data |
| Collaborator Contribution | Ovarian cancer multimarker assays |
| Impact | No outputs so far as BD withdrew from collaboration. The tem was multi-disciplinary involving biomedical scientists, physicians and statistics |
| Start Year | 2011 |
| Description | Proteomic analysis of UKCTOCS serum samples-PROMISE Manchester component |
| Organisation | University of Manchester |
| Department | Institute of Cancer Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of serum and data |
| Collaborator Contribution | Expertise and access to state of the art facilities |
| Impact | Study has started and a number of potential biomarkers for ovarian cancers have been identified in UKCTOCS serum and are under investigation. A translational project grant application to update proteomic methodology has been submitted to the charity 'Target Ovarian Cancer' and the result is pending . The team involved is multi-disciplinary involving researchers from clinical, proteomic and bioinformatics backgrounds |
| Start Year | 2012 |
| Description | Proteomic profiling of human sera for biomarker discovery |
| Organisation | University of Reading |
| Department | School of Biological Sciences Reading |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The development of technologies for serum profiling and the provision of clinical, control and pre-diagnosis serum samples from cases of ovarian, breast cancer and heart disease |
| Collaborator Contribution | The development and application of different proteomic technologies for serum biomarker discovery and data analysis |
| Impact | Five peer-reviewed publications. Award of CR-UK Programme Grant in risk prediction and ealry detection of ovarian cancer. The collaboration on biomarker discovery continues. |
| Description | Risk factors for coronary artery disease |
| Organisation | University College London |
| Department | Institute of Cardiovascular Science |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Study design , grant application and identification of appropriate sample sets. |
| Collaborator Contribution | Expertise in Heart disease |
| Impact | ULCH CBRC grant. Multidisciplinary - Epidemiology and Public Health, Cardiovascular Genetics and Gynaecological Oncology. Data from the study will go into the UCLEB consortia. |
| Start Year | 2009 |
| Description | Use of the Multimarker Algorithm for the Early Detection of Ovarian Cancer in Low Risk Women |
| Organisation | University of Texas |
| Department | M. D. Anderson Cancer Center |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Input into the study design and data interpretation. Preclinical samples from ovarian cancer cases and controls |
| Collaborator Contribution | This collaboration with Professor Bast will enable new technologies and new biomarkers to be assessed in UKCTOCS samples. |
| Impact | Experimental work has been completed and data analysis is underway. The team is multi-disciplinary and are experienced researchers from clinical, biomedical, statistical and proteomic backgrounds |
| Start Year | 2010 |
| Description | cancer specific serum response and development of colorectal cancer |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | study design, serum samples and data interpretion |
| Collaborator Contribution | bioassays and expertise in colorectal cancer |
| Impact | Two publications: Pedersen et al BJC 2013;15;108(1):107-14. Pedersen et al International journal of cancer Journal international du cancer. 2013 Oct 11. |
| Start Year | 2009 |
| Company Name | Abcodia |
| Description | Abcodia is involved in discovery and validation of molecular biomarkers for disease diagnosis and screening. It is the means by which diagnostic, pharmaceutical and technology companies can access serum samples collected in UKCTOCS for the purpose of ethical biomarker validation and discovery. Abcodia are part of the global alliance 'Early Diagnosis Consortium' with Cancer Research UK and Cancer Research Technology Please see website for further information: http://abcodia.com/ |
| Year Established | 2010 |
| Impact | The company is now involved in a number of collaborations including a nested case control study in pancreatic cancer. In Dec 2012,Abcodia won 4 prizes at the NatWest Start up awards : (1) the NatWest Start-Up business of the year (Top prize); (2) Most Innovative business of the year; (3) Best Angel or VC backed business of the year; and (4) Start-Up business woman of the year (Julie Barnes as our Abcodia CEO). Abcodia have steadily been building up th number of collaborations with a variety of partners. To date the company are involved in 13 projects. |
| Website | http://www.abcodia.com/ |
| Description | BBC Interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Supervising a visit by BBC camera crew, selling in the story to BBC, Granada and Manchester Evening News and compiling and distributing a regional version of a press release with Cancer research UK to announce Manchester benefitting from share of Cancer Research UK £100million investment (Professors Ian Jacobs, Alan Jackson, Geoffrey Parker) led to major broadcast and print coverage about the boost to cancer research facilities at The University. This included mentions BBC Breakfast, BBC North West Today, BBC North West lunch time news and BBC North West Tonight including a live lunch time interview at the University. There was also coverage by Granada TV online and a trip by the Manchester Evening News photographer to accompany a page lead in the newspaper on the story. Supervising a visit by BBC camera crew, selling in the story to BBC, Granada and Manchester Evening News and compiling and distributing a regional version of a press release with Cancer research UK to announce Manchester benefitting from share of Cancer Research UK £100million investment (Professors Ian Jacobs, Alan Jackson, Geoffrey Parker) led to major broadcast and print coverage about the boost to cancer research facilities at The University. This included mentions BBC Breakfast, BBC North West Today, BBC North West lunch time news and BBC North West Tonight including a live lunch time interview at the University. There was also coverage by Granada TV online and a trip by the Manchester Evening News photographer to accompany a page lead in the newspaper on the story. |
| Year(s) Of Engagement Activity | 2014 |
| Description | BBC Radio - Interview with Usha Menon regarding UKCTOCS and ovarian cancer screening |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | As part of Ovarian Cancer Awareness Month (March), Prof Menon spoke about ovarian cancer, screening for the disease and the preliminary results of the UKCTOCS trial. Expanding knowledge of ovarian cancer in the general population. |
| Year(s) Of Engagement Activity | 2009 |
| Description | BBC article |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Media coverage of the publication of the prevalence screening results of the UKCTOCS trial. Wide publising of the work to other medical researchers. |
| Year(s) Of Engagement Activity | 2009 |
| Description | Hello magazine |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview with Professor Menon raised awareness for gynaecological cancer and increased traffic too charities such as Eve Appeal |
| Year(s) Of Engagement Activity | 2013 |
| Description | Jacobs IJ, Menon U, Campbell S, Fallowfield L, Parmar S, and Skates SJ. Live Streamed Presentation: UKCTOCS Mortality Results Public Meeting. Royal College of Obstetricians and Gynecologists, London, UK, 17 Dec 2015 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | UKCTOCS Mortality Results Public Meeting |
| Year(s) Of Engagement Activity | 2015 |
| URL | https://www.youtube.com/watch?v=gD8PGK3ieyw |
| Description | Laboratory visits |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The visitors are interested to learn about the work that the research groups do in the field of ovarian cancer. They have an opportunity to speak directly to the researchers and ask questions and to observe samples being processed. Some of visitors have then made donations to charitable organisations such as Eve Appeal. |
| Year(s) Of Engagement Activity | 2008,2009,2010 |
| Description | Media Coverage |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Numerous magazine articles, newspapers, features and journals. During 2013 Comments provided for ovarian cancer awareness article following news of death Pierce Brosnan's daughter were published between 17 July 2013 and 2 August 2013 in 23 regional print newspapers and numerous websites: Raised awareness of ovarian cancer and interest in the group's research. Increase in traffic to ovarian cancer support charities such as Eve Appeal has been noted. |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010,2011,2012,2013 |
| Description | Menon U. Invited Keynote Lecture: Screening for Ovarian Cancer: The Way Forward, 10th Biennial Ovarian Cancer Research Symposium, Seattle, USA, 8th Sept 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Usha Menon Invited Keynote Lecture: 'Screening for Ovarian Cancer: The Way Forward' at the 10th Biennial Ovarian Cancer Research Symposium, Seattle, USA on 8th Sept 2014. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Menon U. Invited Keynote Lecture: Ovarian Cancer Screening, 46th Dr Subodh Mitra Memorial Oration, Kolkata, India, 29th Nov 2013 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Usha Menon Invited Keynote lecture ' Ovarian cancer screening' at the 46th Dr Subodh Mitra Memorial Oration, Bengal Obstetric & Gynaecological Society, Chittaranjan Seva Sadan College of Obstetrics, Kolkata, India on 29th Nov 2013. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Menon U. Invited Plenary lecture: Are we able to effectively screen for ovarian cancer?, 16th Biennial Meeting of the International Gynecologic Cancer Society, Lisbon, Portugal, 29 Oct 2016 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Usha Menon was an invited speaker to give lecture: 'Are we able to effectively screen for ovarian cancer?' at the 16th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2016), 29 Oct 2016, Lisbon Congress Centre, Lisbon, Portugal |
| Year(s) Of Engagement Activity | 2015 |
| Description | Menon U. Invited Plenary lecture: Ovarian Cancer Screening, Northern Sweden Gynecologic Society, Umeå University, Sweden, 25th Feb 2016 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Usha Menon invited Plenary lecture 'Ovarian cancer screening' at the Northern Sweden Gynecologic Society, Umeå University, Sweden on 25th Feb 2016. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Menon U. Invited Plenary lecture: Ovarian cancer screening, AACR Advances in Ovarian Cancer Research: Exploiting Vulnerabilities, Florida, USA, 19th Oct 2015 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Usha Menon invited Plenary lecture: Ovarian cancer screening, AACR Advances in Ovarian Cancer Research: Exploiting Vulnerabilities on 19th Oct 2015, Orlando, Florida, USA. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Menon U. Invited Plenary lecture: UKCTOCS - Exploring the Results, 11th Biennial Ovarian Cancer Research Symposium, University of Washington, USA, 12th Sept 2016 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Usha Menon Invited Plenary lecture 'UKCTOCS - exploring the results' at the 11th Biennial Ovarian Cancer Research Symposium, 12th Sept 2016, University of Washington, Seattle, Washington DC, USA. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Menon U. Invited Talk: Advances in Ovarian Cancer Research: Exploiting Vulnerabilities, 17 - 20 Oct 2015, Orlando, Florida, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Menon U. Invited Talk: Advances in Ovarian Cancer Research: Exploiting Vulnerabilities, 17 - 20 Oct 2015, Orlando, Florida, USA |
| Year(s) Of Engagement Activity | 2015 |
| Description | Menon U. Invited Talk: Memorable research moments in the context of Women's Health, Perinatal Research Meeting UCLH, 4 Mar 2016 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Menon U. Invited Talk: Memorable research moments in the context of Women's Health, Perinatal Research Meeting UCLH, 4 Mar 2016 |
| Year(s) Of Engagement Activity | 2016 |
| Description | Menon U. Invited Talk: Ovarian Cancer - UKCTOCS study: the outcomes, 3rd ENGAGe Patient Seminar, Nice, France, 24 Oct 2015 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Menon U. Invited Talk: Ovarian Cancer - UKCTOCS study: the outcomes, 3rd ENGAGe Patient Seminar, Nice, France, 24 Oct 2015 |
| Year(s) Of Engagement Activity | 2015 |
| Description | Menon U. Invited Talk: Ovarian Cancer screening - update from the UK trials, 2015 NCRI Cancer Conference, 1 - 4 Nov 2015, Liverpool, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Menon U. Invited Talk: Ovarian Cancer screening - update from the UK trials, 2015 NCRI Cancer Conference, 1 - 4 Nov 2015, Liverpool, UK |
| Year(s) Of Engagement Activity | 2015 |
| Description | Menon U. Invited Talk: Ovarian cancer screening - role of biomarkers, 4th Biomarkers in Diagnostics, 8 Oct 2015, Berlin, Germany |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Menon U. Invited Talk: Ovarian cancer screening - role of biomarkers, 4th Biomarkers in Diagnostics, 8 Oct 2015, Berlin, Germany |
| Year(s) Of Engagement Activity | 2015 |
| Description | Menon U. Invited Talk: Ovarian cancer screening: where are we now? South Wales Gynaecological Oncology Group - 12th Educational Meeting, Innovations Hub in Cardiiff Bay, 3 Assembly Square, Cardiff Bay, 27 Nov 2015 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Menon U. Invited Talk: Ovarian cancer screening: where are we now? South Wales Gynaecological Oncology Group - 12th Educational Meeting, Innovations Hub in Cardiiff Bay, 3 Assembly Square, Cardiff Bay, 27 Nov 2015 |
| Year(s) Of Engagement Activity | 2015 |
| Description | Menon U. Invited Talk: Ovarian screening latest news, London Cancer Gynaecology Annual Education Open Meeting, UCLPartners, London, UK, 18 June 2015 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Menon U. Invited Talk: Ovarian screening latest news, London Cancer Gynaecology Annual Education Open Meeting, UCLPartners, London, UK, 18 June 2015 |
| Year(s) Of Engagement Activity | 2015 |
| Description | Menon U. Invited Talk: The UKCTOCS and UKFOCSS trials - what have we learnt so far? 2nd International Ovarian Tumor Analysis Congress (IOTA 2015), 17 Apr 2015, Leuven, Belgium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Menon U. Invited Talk: The UKCTOCS and UKFOCSS trials - what have we learnt so far? 2nd International Ovarian Tumor Analysis Congress (IOTA 2015), 17 Apr 2015, Leuven, Belgium |
| Year(s) Of Engagement Activity | 2015 |
| Description | Menon U. Invited Talk: UKCTOCS update, RCOG Annual Professional Development Conference, 24 - 26 Nov 2015, London, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Menon U. Invited Talk: UKCTOCS update, RCOG Annual Professional Development Conference, 24 - 26 Nov 2015, London, UK |
| Year(s) Of Engagement Activity | 2015 |
| Description | Menon U. Invited talk: Mortality outcomes of the UK Ovarian Cancer Screening programme (UKCTOCS), British Society for Gynaecological Imaging Annual Scientific Meeting, RCOG, London, UK, 16th April 2016 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Usha Menon invited talk 'Mortality outcomes of the UK Ovarian Cancer Screening programme (UKCTOCS)' at the British Society for Gynaecological Imaging (BSGI) Annual Scientific Meeting, RCOG, London, UK on 16th April 2016. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Menon U. Invited talk: Ovarian cancer screening - role of biomarkers, 4th Biomarkers in Diagnoscs, Berlin, Germany, 8th Oct 2015 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Usha Menon invited talk 'Ovarian cancer screening - role of biomarkers' at the 4th Biomarkers in Diagnoscs, Berlin, Germany on 8th Oct 2015. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Menon U. Invited talk: Ovarian cancer screening - what do we know now?, British Gynaecological Cancer Society Annual Scientific Meeting, The ICC, Birmingham, UK, 12th May 2016 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Usha Menon invited talk 'Ovarian cancer screening - what do we know now?' at the British Gynaecological Cancer Society Annual Scientific Meeting (BGCS 2016), 12th May 2016, The ICC, Birmingham, UK. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Menon U. Invited talk: Ovarian cancer screening, New Cancer Screening Programmes, Swedish Medical Society, Stockholm, Sweden, 6th October 2016 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Usha Menon Invited talk on 'Ovarian cancer screening, New Cancer Screening Programmes' at Swedish Medical Society, Stockholm, Sweden on 6th October 2016. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Menon U. Invited talk: Screening for Ovarian Cancer, Biennial Ovarian Cancer Symposium, Singapore, 27th June 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Usha Menon invited talk 'Screening for Ovarian Cancer' at the Biennial Ovarian Cancer Symposium, National University of Singapore, Singapore on 27th June 2014. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Menon U. Invited talk: The UK Collaborative Trial of Ovarian Cancer Screening - Outcomes, UCL Frontiers of Oncology: Women's Health, Royal College of Physicians, London, UK, 28th Sept 2016 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Usha Menon invited talk 'The UK Collaborative Trial of Ovarian Cancer Screening - Outcomes' at UCL Frontiers of Oncology: Women's Health, Royal College of Physicians, London, UK on 28th Sept 2016. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Menon U. Invited talk: Update on the UKCTOCS trial: Compliance, performance of MMS & USS arms, stage distribution, After UKCTOCS, Public Messaging on Screening and Early Detection of Ovarian Cancer, Banbury Center, Cold Spring Harbor Laboratory, USA, 8th Feb 2016 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Usha Menon invited talk 'Update on the UKCTOCS trial: Compliance, performance of MMS & USS arms, stage distribution, After UKCTOCS' at the Public Messaging on Screening and Early Detection of Ovarian Cancer, Banbury Center, Cold Spring Harbor Laboratory, USA on 8th Feb 2016. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Ovarian Cancer Inquiry, All Party Parliamentary Group on Ovarian Cancer, Target Ovarian Cancer, The House of Commons, Westminster, London, UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | The All-Party Parliamentary Group (APPG) on Ovarian Cancer was established in 2010 to facilitate greater understanding and awareness of ovarian cancer among parliamentarians. The APPG has focused much of its work on what can be done to improve early diagnosis of ovarian cancer. Prof Menon gave evidence to the panel and answered questions regarding two UK studies - UKCTOCS and UKFOCSS. APPG commended that two such high-calibre studies into screening for ovarian cancer have taken place although it is disappointing that these have not yet been able to conclude conclusively in favour of a screening programme for either women in the general population or those at a heightened risk of developing ovarian cancer. The Inquiry welcomed the positive commitment made by Public Health England should final results for the two studies demonstrate a positive impact on mortality, while also noting the potential challenges posed by the need for a suitably trained sonographer workforce. On this basis the APPG on Ovarian Cancer makes the following recommendation: For NHS England and Health Education England to factor a potential increase in demand for sonographers in their workforce planning. The report was published by Target Ovarian Cancer to coincide with World Ovarian Cancer Day on 8 May 2018. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Progress with Population Screening for Ovarian Cancer at ICUH Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | * |
| Year(s) Of Engagement Activity | 2013 |
| URL | https://www.icuh2014.com |
| Description | Research Feedback Event |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | Approximately 150 people attended the meeting which consisted of oral and poster presentations allowing opportunities for networking between charity supporters, trustees and researchers. members of the public who attended signed up to receive regular newsletters from the charity and also to participate in fund raising events or make donations to the charity |
| Year(s) Of Engagement Activity | 2013 |
| Description | Sky News interview with Professor Ian Jacobs |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with Sky News into his research into ovarian cancer * |
| Year(s) Of Engagement Activity | 2014 |
| Description | Talk at Festival of Public Health Event |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Questions and answers afterwards tbc |
| Year(s) Of Engagement Activity | 2013 |
| Description | Target Ovarian Cancer presentation - The current states of screening for ovarian cancer |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | * |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.targetovariancancer.org.uk/news/'ask-experts'-podcast-status-ovarian-cancer-screening |
| Description | Thank you card |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | Paper Presentation |
| Geographic Reach | National |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | With the help of an artist we designed a card to thank women in UKCTOCS which was posted out to approximately 200,000 participants after the close of screening in the trial. Approximately 30,000 women responded within 3 weeks with positive feedback about the trial's impact on them. As a consequence of the thank you card the study team obtained health status updates from the participants and change of address notifications which will assist for the mailing out our final study questionnaire. In addition, women had an opportunity to undertake fund raising activity via the charity Eve Appeal. The project relating to generation of the card was presented as the Institute for Women's health annual meeting as a poster |
| Year(s) Of Engagement Activity | 2012 |
| Description | UKCTOCS Newsletter |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | This is difficult to assess as we have more than 200,000 women in our trial and only a very small fraction wrote in to provide feedback. Women in UKCTOCS were informed of the trial progress and new developments. |
| Year(s) Of Engagement Activity | 2007 |