UK Collaborative Trial of Ovarian Cancer Screening

Lead Research Organisation: University College London
Department Name: Maternal & Fetal Medicine

Abstract

UKCTOCS aims to assess whether ovarian cancer screening will save lives while comprehensively evaluating the screening strategies available, the worry and complications associated with screening and ensuing surgery, compliance and the potential resource implications for the NHS. Women aged 50-74 in 13 regions in the UK were invited to take part. The 202,638 women who joined the study were randomly allocated to an observation (control) group or screening with transvaginal ultrasound (USS)for 6 years or screening with a blood test called CA125 for 6 years. All women are being followed up by postal questionnaire and through the Office for National Statistics to establish whether or not they develop ovarian cancer or die of the disease. Screening is ongoing and the study has met all its targets on recruitment, retention and follow up. Currently each woman is in the trial for 7 years from randomisation and the trial will be complete in 2012. Hoever, it is now clear that there are less deaths from ovarian cancer than expected in the women in the control group who have not been screened. As a result of thos healthy volunteer effect the trial needs to be extended to obtain a clear answer to the question - Can ovarian cancer screening save lives? The best approach will be to extend screening until 2011 and follow up everyone until 2014.

Technical Summary

UKCTOCS is a RCT to assess impact of screening on ovarian cancer mortality while evaluating performance characteristics of screening, physical and psychological morbidity, compliance and resource implications. Women aged 50-74 were invited from 27 Primary Care Trusts adjoining 13 trial centres. Women who accepted were invited to recruitment and 202,638 were randomised to an observation (control) group or 6 annual screens with transvaginal ultrasound (USS)or serum CA125 (M)in a 2:1:1 ratio. All women are being followed up by postal questionnaire and ?flagging? through the Office for National Statistics. Screening is ongoing and the study has met all its targets for recruitment, retention and follow up. Currently each woman is in the trial for 7 years from randomisation and the trial will be complete in 2012. It has now become clear that the number of age adjusted observed deaths (OD) in UKCTOCS participants is significantly reduced compared to expected deaths (ED), based on ONS mortality statistics. The overall Standardised Mortality Ratio (SMR - ratio of OD/ED expressed as a percentage) is 31.6 and for ovarian cancer is estimated at 65. As a result of this healthy volunteer effect, there will be a shortfall in power. An extension is therefore requested to compensate for this effect. Various options have been explored to increase events in the control arm. The favoured option based on cost and time to trial completion is extending trial participation to the end of 2014 with all women in the screened arm undergoing screening till end of 2011.

Publications

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publication icon
Borges M (2017) Metabolic Profiling of Adiponectin Levels in Adults Mendelian Randomization Analysis in Circulation: Cardiovascular Genetics

 
Title Creation of artwork for thank you card for UKCTOCS volunteers 
Description A painting of a primary ovarian follicle was created by a commissioned artist (Dr Lizzie Burns). The image of painting was digitized so that each dot represented 8 women participants in the trial. This digitized image was then used on the front of a card that was posted at the end of the screening period to all the the UKCTOCS volunteers to thank them for their participation in the trial. mailin was performed in collaboration with the charity, The Eve Appeal. The package also contained information about the trial and what was to happen during the follow-up period of UKCTOCS. 
Type Of Art Artwork 
Year Produced 2012 
Impact Approximately 30,000 replies were received back from the women within three weeks of mailing- expressing huge appreciation of the trial and what its was trying to achieve, that the team had 'remembered' the volunteers. Many volunteers touched by the gesture. In women where a cancer had been detected, felt that the trial had saved their lives. Added benefit was that the The Eve Appeal database of donors was increased . 
URL https://www.ucl.ac.uk/instituteforwomenshealth/news/oldnewsletters/new-letters-tabbed-box/2012/2012m...
 
Guideline Title The UK NSC recommendation on Ovarian cancer screening in women
Description Ovarian Cancer Screening Guideline
Geographic Reach National 
Policy Influence Type Citation in clinical guidelines
 
Guideline Title Screening for Ovarian Cancer US Preventive Services Task Force Recommendation Statement
Description Ovarian Cancer Screening Guideline
Geographic Reach North America 
Policy Influence Type Citation in clinical guidelines
URL https://jamanetwork.com/journals/jama/fullarticle/2672638
 
Guideline Title Testing for ovarian cancer in asymptomatic women
Description Ovarian Cancer Screening Guideline
Geographic Reach Australia 
Policy Influence Type Citation in clinical guidelines
URL https://canceraustralia.gov.au/publications-and-resources/position-statements/testing-ovarian-cancer...
 
Guideline Title Guidelines for preventive activities in general practice The Red Book 9.6 Ovarian Cancer
Description Ovarian Cancer Screening Guideline
Geographic Reach Australia 
Policy Influence Type Citation in clinical guidelines
URL https://www.racgp.org.au/clinical-resources/clinical-guidelines/key-racgp-guidelines/view-all-racgp-...
 
Description Ovarian cancer awareness consultation
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description Training of UKCTOCS sonographers
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
 
Description CRUK BIDD Project Grant
Amount £185,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2011 
End 03/2013
 
Description CRUK TRICC Project Grant
Amount £145,154 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 11/2010
 
Description DH Service Support Costs UKCTOCS
Amount £6,000,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
End 06/2015
 
Description EU FP7
Amount £90,000 (GBP)
Funding ID HEALTH-F5-2012-305428 
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start  
 
Description MRC Clinical Trial Grant (UKCTOCS Extension of Screening)
Amount £2,303,175 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2010 
End 08/2015
 
Description MRC Training Grant: Industrial Case Award
Amount £118,230 (GBP)
Funding ID MR/J006718/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2012 
End 08/2016
 
Description NIHR UCLH Biomedical Research Centre Cancer Programme Funding
Amount £100,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 06/2014 
End 05/2016
 
Description PRC Programme Grant -CRUK component
Amount £1,620,000 (GBP)
Funding ID C1005/A12677 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2011 
End 08/2016
 
Description PRC Programme grant - EVE Appeal component
Amount £1,641,890 (GBP)
Organisation The Eve Appeal 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2011 
End 08/2016
 
Description Pancreatic Cancer UK Project grant
Amount £149,391 (GBP)
Organisation Pancreatic Cancer UK 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2011 
End 07/2013
 
Description Pancreatic cancer UK Pump priming grant
Amount £10,000 (GBP)
Organisation Pancreatic Society of Great Britain and Ireland (PanSoc) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Programme of Translational Research in Gynaecological cancer (UCL & Special Trustees UCLH)
Amount £1,100,000 (GBP)
Organisation University College London 
Sector Academic/University
Country United Kingdom
Start  
 
Description UCL/UCLH CBRC New Initiatives
Amount £35,647 (GBP)
Organisation National Institute for Health Research 
Department UCLH/UCL Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 01/2009 
End 01/2010
 
Description UCLH/UCL Comprehensive Biomedical Research Centre (Epigenetic and Genetic analysis in UKCTOCS)
Amount £800,000 (GBP)
Organisation National Institute for Health Research 
Department UCLH/UCL Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 03/2009 
End 12/2014
 
Title A database of serum peptide identifications 
Description The identities of low-molecular weight serum peptides found using our profiling platform has been determined and a database of these assembled for reference in future profiling studies 
Type Of Material Biological samples 
Year Produced 2009 
Provided To Others? Yes  
Impact Publication of the data and use in other biomarker discovery projects 
 
Title A reproducible platform for serum peptide profiling 
Description A platform incorporating robotic extraction of peptides from serum on magnetic beads and sample spotting linked to automated MALDI-TOF MS data acquisition was developed for high-throughput profiling of low-mass polypeptides in the serum of clinical sample sets 
Type Of Material Technology assay or reagent 
Year Produced 2009 
Provided To Others? Yes  
Impact The platform has been applied on mutliple biomarker discovery projects using serum from case control collections and pre-diagnosis samples from UKCTOCS 
 
Title Cost recovery tool for biobanks 
Description We have developed a cost recovery tool to calculate costs for sharing of data and samples in a transparent and reproducible manner 
Type Of Material Improvements to research infrastructure 
Year Produced 2018 
Provided To Others? No  
Impact We also use the tool with regard to our other bioresources and it has helped with cost recovery and sustainibility. 
 
Title UKCTOCS trial management system 
Description Database system that assists in running of the trial. 
Type Of Material Biological samples 
Provided To Others? No  
Impact Streamlined running of all aspects of UKCTOCS. 
 
Title UKLWC 
Description UK Longitudinal Women's Cohort is the bioresource created during the course of UKCTOCS. With over 202,000 women, 5.5 million donated serum samples and over 14 years follow-up through electronic health record linkage, this complements UK Biobank. 
Type Of Material Biological samples 
Year Produced 2010 
Provided To Others? Yes  
Impact A number of publications mainly focused on early detection biomarkers 
URL https://www.ucl.ac.uk/womens-health/research/womens-cancer/gynaecological-cancer-research-centre/ukl...
 
Title Ultrasound Record Archive 
Description We are databasing static ultrasound images collected during the UKCTOCS trial which will serve as an electronic source for review and management of women on the trial. In addition it enables training and refinement of techniques for assessing the ultrasound images. There is huge potential also for pursuing future research in imaging postmenopausal ovaries in health and in cancer. Currently have 255,472 archived TVS examinations. 
Type Of Material Biological samples 
Provided To Others? No  
Impact The database is currently incomplete but represents a major resource for investigation and training. The major benefit of this electronic resource is ease of access and rapidity to volunteer scanning results. It also provides a means for checking the quality of ultrasonography in UKCTOCS. In terms of research efforts it represent a significant resource for a variety of analyses, including assessment of ultrasound findings in malignant lesions in ovarian and other gynaecological cancers. The URA also has the potential to help refine and set standards for ultrasound image analysis. 
 
Description Biomarker assessment in preclinical samples from UKCTOCS 
Organisation Fred Hutchinson Cancer Research Center (FHCRC)
Department Molecular Diagnostics Program (FHCRC)
Country United States 
Sector Charity/Non Profit 
PI Contribution Providing samples and data from controls and ovarian cancer cases
Collaborator Contribution Access to novel biomarker assays
Impact Bilateral partnership - Agreement, Ethics and MTA in place.
Start Year 2010
 
Description Discovery of biomarkers of biliary tract and pancreatic cancer 
Organisation University College London
Department Institute of Liver and Digestive Health
Country United Kingdom 
Sector Academic/University 
PI Contribution Proteomic profiling of clinical and control samples of biliary tract cancer and training of a PhD student. Proteomic profiling of pre-diagnosis and matched healthy control serum samples and case controls in a pancreatic cancer biomarker discovery and validation project.
Collaborator Contribution Provision of expertise in pancreatic and biliary tract cancers and access to clinical samples for biomarker discoveryAccess to case control samples of benign pancreatic disease and pancreatic cancer for biomarker discovery
Impact Award of PancSoc GB&I pump priming grant to validate reported markers of pancreatic cancer in prediagnosis and control samples. Award of CRUK TRICC pilot grant, CRUK BIDD Project grant and Pancreatic cancer UK grant aimed at discovery of serum biomarkers of pancreatic cancer. Identification of promising candidate biomarkers and one publications accepted and another submitted.
Start Year 2008
 
Description Discovery of biomarkers of biliary tract and pancreatic cancer 
Organisation University of Liverpool
Department Medicine and Surgery
Country United Kingdom 
Sector Academic/University 
PI Contribution Proteomic profiling of clinical and control samples of biliary tract cancer and training of a PhD student. Proteomic profiling of pre-diagnosis and matched healthy control serum samples and case controls in a pancreatic cancer biomarker discovery and validation project.
Collaborator Contribution Provision of expertise in pancreatic and biliary tract cancers and access to clinical samples for biomarker discoveryAccess to case control samples of benign pancreatic disease and pancreatic cancer for biomarker discovery
Impact Award of PancSoc GB&I pump priming grant to validate reported markers of pancreatic cancer in prediagnosis and control samples. Award of CRUK TRICC pilot grant, CRUK BIDD Project grant and Pancreatic cancer UK grant aimed at discovery of serum biomarkers of pancreatic cancer. Identification of promising candidate biomarkers and one publications accepted and another submitted.
Start Year 2008
 
Description Discovery of biomarkers of pancreatobiliary disease 
Organisation University College London
Department Institute of Liver and Digestive Health
Country United Kingdom 
Sector Academic/University 
PI Contribution Samples from UKCTOCS have been provided to collaborators for biomarker testing and discovery using complementary techniques to those applied at UCL
Collaborator Contribution Provision of expertise in pancreatic and biliary tract cancers and access to clinical samples for biomarker discoveryProvision of expertise in pancreatic cancer and access to additional case control serum samples relevant to biomarker discovery
Impact Award of PancSoc GB&I pump priming grant to validate reported markers of pancreatic cancer in prediagnosis and control samples. Award of CRUK TRICC pilot grant, CRUK BIDD Project grant and Pancreatic cancer UK grant aimed at discovery of serum biomarkers of pancreatic cancer. Identification of promising candidate biomarkers with one publication accepted and another submitted.
Start Year 2008
 
Description Discovery of biomarkers of pancreatobiliary disease 
Organisation University of Liverpool
Department Department of Molecular and Clinical Cancer Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Samples from UKCTOCS have been provided to collaborators for biomarker testing and discovery using complementary techniques to those applied at UCL
Collaborator Contribution Provision of expertise in pancreatic and biliary tract cancers and access to clinical samples for biomarker discoveryProvision of expertise in pancreatic cancer and access to additional case control serum samples relevant to biomarker discovery
Impact Award of PancSoc GB&I pump priming grant to validate reported markers of pancreatic cancer in prediagnosis and control samples. Award of CRUK TRICC pilot grant, CRUK BIDD Project grant and Pancreatic cancer UK grant aimed at discovery of serum biomarkers of pancreatic cancer. Identification of promising candidate biomarkers with one publication accepted and another submitted.
Start Year 2008
 
Description Hormonal Profile in Breast cancer 
Organisation University College London
Department UCL Cancer Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Samples and data from UKCTOCS volunteers who developed breast cancer
Collaborator Contribution Expertise in Breast cancer
Impact A PhD awarded and two publications: Fourkala EO et al Endocrine-related cancer. 2012 Apr;19(2):137-47. Fourkala EO et al Br J Cancer. 2012 Jun 5;106(12):1910-6.
Start Year 2008
 
Description MRC Proteomics biomarker discovery 
Organisation University College London
Department UCL Cancer Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Use of UKCTOCS samples for the biomarker discovery project.
Impact MRC Grant for proteomic discovery of biomarkers for ovarian cancer.Project complete. Details of publications are provided in the publications section.
Start Year 2006
 
Description Multianalyte assay for early diagnosis of ovarian cancer 
Organisation University of Pittsburgh
Department School of Medicine Pittsburgh
Country United States 
Sector Academic/University 
PI Contribution Input into the study design and data interpretation. Preclinical samples and data from ovarian cancer cases and controls
Collaborator Contribution Enabling assessment of serum biomarkers in multiplex system.
Impact Project ongoing - intial sample sets have been shipped to our Collaborators and are being assayed. Results from sample testing are pending.
Start Year 2007
 
Description Pilot study-Ovarian Cancer Biomarker discovery 
Organisation Becton, Dickinson and Company
Country United States 
Sector Private 
PI Contribution Provision of serum and data
Collaborator Contribution Ovarian cancer multimarker assays
Impact No outputs so far as BD withdrew from collaboration. The tem was multi-disciplinary involving biomedical scientists, physicians and statistics
Start Year 2011
 
Description Proteomic analysis of UKCTOCS serum samples-PROMISE Manchester component 
Organisation University of Manchester
Department Institute of Cancer Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of serum and data
Collaborator Contribution Expertise and access to state of the art facilities
Impact Study has started and a number of potential biomarkers for ovarian cancers have been identified in UKCTOCS serum and are under investigation. A translational project grant application to update proteomic methodology has been submitted to the charity 'Target Ovarian Cancer' and the result is pending . The team involved is multi-disciplinary involving researchers from clinical, proteomic and bioinformatics backgrounds
Start Year 2012
 
Description Proteomic profiling of human sera for biomarker discovery 
Organisation University of Reading
Department School of Biological Sciences Reading
Country United Kingdom 
Sector Academic/University 
PI Contribution The development of technologies for serum profiling and the provision of clinical, control and pre-diagnosis serum samples from cases of ovarian, breast cancer and heart disease
Collaborator Contribution The development and application of different proteomic technologies for serum biomarker discovery and data analysis
Impact Five peer-reviewed publications. Award of CR-UK Programme Grant in risk prediction and ealry detection of ovarian cancer. The collaboration on biomarker discovery continues.
 
Description Risk factors for coronary artery disease 
Organisation University College London
Department Institute of Cardiovascular Science
Country United Kingdom 
Sector Academic/University 
PI Contribution Study design , grant application and identification of appropriate sample sets.
Collaborator Contribution Expertise in Heart disease
Impact ULCH CBRC grant. Multidisciplinary - Epidemiology and Public Health, Cardiovascular Genetics and Gynaecological Oncology. Data from the study will go into the UCLEB consortia.
Start Year 2009
 
Description Use of the Multimarker Algorithm for the Early Detection of Ovarian Cancer in Low Risk Women 
Organisation University of Texas
Department M. D. Anderson Cancer Center
Country United States 
Sector Academic/University 
PI Contribution Input into the study design and data interpretation. Preclinical samples from ovarian cancer cases and controls
Collaborator Contribution This collaboration with Professor Bast will enable new technologies and new biomarkers to be assessed in UKCTOCS samples.
Impact Experimental work has been completed and data analysis is underway. The team is multi-disciplinary and are experienced researchers from clinical, biomedical, statistical and proteomic backgrounds
Start Year 2010
 
Description cancer specific serum response and development of colorectal cancer 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution study design, serum samples and data interpretion
Collaborator Contribution bioassays and expertise in colorectal cancer
Impact Two publications: Pedersen et al BJC 2013;15;108(1):107-14. Pedersen et al International journal of cancer Journal international du cancer. 2013 Oct 11.
Start Year 2009
 
Company Name Abcodia 
Description Abcodia is involved in discovery and validation of molecular biomarkers for disease diagnosis and screening. It is the means by which diagnostic, pharmaceutical and technology companies can access serum samples collected in UKCTOCS for the purpose of ethical biomarker validation and discovery. Abcodia are part of the global alliance 'Early Diagnosis Consortium' with Cancer Research UK and Cancer Research Technology Please see website for further information: http://abcodia.com/ 
Year Established 2010 
Impact The company is now involved in a number of collaborations including a nested case control study in pancreatic cancer. In Dec 2012,Abcodia won 4 prizes at the NatWest Start up awards : (1) the NatWest Start-Up business of the year (Top prize); (2) Most Innovative business of the year; (3) Best Angel or VC backed business of the year; and (4) Start-Up business woman of the year (Julie Barnes as our Abcodia CEO). Abcodia have steadily been building up th number of collaborations with a variety of partners. To date the company are involved in 13 projects.
Website http://www.abcodia.com/
 
Description BBC Interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Participants in your research and patient groups
Results and Impact Supervising a visit by BBC camera crew, selling in the story to BBC, Granada and Manchester Evening News and compiling and distributing a regional version of a press release with Cancer research UK to announce Manchester benefitting from share of Cancer Research UK £100million investment (Professors Ian Jacobs, Alan Jackson, Geoffrey Parker) led to major broadcast and print coverage about the boost to cancer research facilities at The University. This included mentions BBC Breakfast, BBC North West Today, BBC North West lunch time news and BBC North West Tonight including a live lunch time interview at the University. There was also coverage by Granada TV online and a trip by the Manchester Evening News photographer to accompany a page lead in the newspaper on the story.



Supervising a visit by BBC camera crew, selling in the story to BBC, Granada and Manchester Evening News and compiling and distributing a regional version of a press release with Cancer research UK to announce Manchester benefitting from share of Cancer Research UK £100million investment (Professors Ian Jacobs, Alan Jackson, Geoffrey Parker) led to major broadcast and print coverage about the boost to cancer research facilities at The University. This included mentions BBC Breakfast, BBC North West Today, BBC North West lunch time news and BBC North West Tonight including a live lunch time interview at the University. There was also coverage by Granada TV online and a trip by the Manchester Evening News photographer to accompany a page lead in the newspaper on the story.
Year(s) Of Engagement Activity 2014
 
Description BBC Radio - Interview with Usha Menon regarding UKCTOCS and ovarian cancer screening 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact As part of Ovarian Cancer Awareness Month (March), Prof Menon spoke about ovarian cancer, screening for the disease and the preliminary results of the UKCTOCS trial.

Expanding knowledge of ovarian cancer in the general population.
Year(s) Of Engagement Activity 2009
 
Description BBC article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Media coverage of the publication of the prevalence screening results of the UKCTOCS trial.

Wide publising of the work to other medical researchers.
Year(s) Of Engagement Activity 2009
 
Description Hello magazine 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Interview with Professor Menon

raised awareness for gynaecological cancer and increased traffic too charities such as Eve Appeal
Year(s) Of Engagement Activity 2013
 
Description Jacobs IJ, Menon U, Campbell S, Fallowfield L, Parmar S, and Skates SJ. Live Streamed Presentation: UKCTOCS Mortality Results Public Meeting. Royal College of Obstetricians and Gynecologists, London, UK, 17 Dec 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact UKCTOCS Mortality Results Public Meeting
Year(s) Of Engagement Activity 2015
URL https://www.youtube.com/watch?v=gD8PGK3ieyw
 
Description Laboratory visits 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The visitors are interested to learn about the work that the research groups do in the field of ovarian cancer. They have an opportunity to speak directly to the researchers and ask questions and to observe samples being processed.

Some of visitors have then made donations to charitable organisations such as Eve Appeal.
Year(s) Of Engagement Activity 2008,2009,2010
 
Description Media Coverage 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Numerous magazine articles, newspapers, features and journals.
During 2013 Comments provided for ovarian cancer awareness article following news of death Pierce Brosnan's daughter were published between 17 July 2013 and 2 August 2013 in 23 regional print newspapers and numerous websites:

Raised awareness of ovarian cancer and interest in the group's research. Increase in traffic to ovarian cancer support charities such as Eve Appeal has been noted.
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010,2011,2012,2013
 
Description Menon U. Invited Keynote Lecture: Screening for Ovarian Cancer: The Way Forward, 10th Biennial Ovarian Cancer Research Symposium, Seattle, USA, 8th Sept 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Usha Menon Invited Keynote Lecture: 'Screening for Ovarian Cancer: The Way Forward' at the 10th Biennial Ovarian Cancer Research Symposium, Seattle, USA on 8th Sept 2014.
Year(s) Of Engagement Activity 2014
 
Description Menon U. Invited Keynote Lecture: Ovarian Cancer Screening, 46th Dr Subodh Mitra Memorial Oration, Kolkata, India, 29th Nov 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Usha Menon Invited Keynote lecture ' Ovarian cancer screening' at the 46th Dr Subodh Mitra Memorial Oration, Bengal Obstetric & Gynaecological Society, Chittaranjan Seva Sadan College of Obstetrics, Kolkata, India on 29th Nov 2013.
Year(s) Of Engagement Activity 2013
 
Description Menon U. Invited Plenary lecture: Are we able to effectively screen for ovarian cancer?, 16th Biennial Meeting of the International Gynecologic Cancer Society, Lisbon, Portugal, 29 Oct 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Usha Menon was an invited speaker to give lecture: 'Are we able to effectively screen for ovarian cancer?' at the 16th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2016), 29 Oct 2016, Lisbon Congress Centre, Lisbon, Portugal
Year(s) Of Engagement Activity 2015
 
Description Menon U. Invited Plenary lecture: Ovarian Cancer Screening, Northern Sweden Gynecologic Society, Umeå University, Sweden, 25th Feb 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Usha Menon invited Plenary lecture 'Ovarian cancer screening' at the Northern Sweden Gynecologic Society, Umeå University, Sweden on 25th Feb 2016.
Year(s) Of Engagement Activity 2016
 
Description Menon U. Invited Plenary lecture: Ovarian cancer screening, AACR Advances in Ovarian Cancer Research: Exploiting Vulnerabilities, Florida, USA, 19th Oct 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Usha Menon invited Plenary lecture: Ovarian cancer screening, AACR Advances in Ovarian Cancer Research: Exploiting Vulnerabilities on 19th Oct 2015, Orlando, Florida, USA.
Year(s) Of Engagement Activity 2015
 
Description Menon U. Invited Plenary lecture: UKCTOCS - Exploring the Results, 11th Biennial Ovarian Cancer Research Symposium, University of Washington, USA, 12th Sept 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Usha Menon Invited Plenary lecture 'UKCTOCS - exploring the results' at the 11th Biennial Ovarian Cancer Research Symposium, 12th Sept 2016, University of Washington, Seattle, Washington DC, USA.
Year(s) Of Engagement Activity 2016
 
Description Menon U. Invited Talk: Advances in Ovarian Cancer Research: Exploiting Vulnerabilities, 17 - 20 Oct 2015, Orlando, Florida, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Menon U. Invited Talk: Advances in Ovarian Cancer Research: Exploiting Vulnerabilities, 17 - 20 Oct 2015, Orlando, Florida, USA
Year(s) Of Engagement Activity 2015
 
Description Menon U. Invited Talk: Memorable research moments in the context of Women's Health, Perinatal Research Meeting UCLH, 4 Mar 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Menon U. Invited Talk: Memorable research moments in the context of Women's Health, Perinatal Research Meeting UCLH, 4 Mar 2016
Year(s) Of Engagement Activity 2016
 
Description Menon U. Invited Talk: Ovarian Cancer - UKCTOCS study: the outcomes, 3rd ENGAGe Patient Seminar, Nice, France, 24 Oct 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Menon U. Invited Talk: Ovarian Cancer - UKCTOCS study: the outcomes, 3rd ENGAGe Patient Seminar, Nice, France, 24 Oct 2015
Year(s) Of Engagement Activity 2015
 
Description Menon U. Invited Talk: Ovarian Cancer screening - update from the UK trials, 2015 NCRI Cancer Conference, 1 - 4 Nov 2015, Liverpool, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Menon U. Invited Talk: Ovarian Cancer screening - update from the UK trials, 2015 NCRI Cancer Conference, 1 - 4 Nov 2015, Liverpool, UK
Year(s) Of Engagement Activity 2015
 
Description Menon U. Invited Talk: Ovarian cancer screening - role of biomarkers, 4th Biomarkers in Diagnostics, 8 Oct 2015, Berlin, Germany 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Menon U. Invited Talk: Ovarian cancer screening - role of biomarkers, 4th Biomarkers in Diagnostics, 8 Oct 2015, Berlin, Germany
Year(s) Of Engagement Activity 2015
 
Description Menon U. Invited Talk: Ovarian cancer screening: where are we now? South Wales Gynaecological Oncology Group - 12th Educational Meeting, Innovations Hub in Cardiiff Bay, 3 Assembly Square, Cardiff Bay, 27 Nov 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Menon U. Invited Talk: Ovarian cancer screening: where are we now? South Wales Gynaecological Oncology Group - 12th Educational Meeting, Innovations Hub in Cardiiff Bay, 3 Assembly Square, Cardiff Bay, 27 Nov 2015
Year(s) Of Engagement Activity 2015
 
Description Menon U. Invited Talk: Ovarian screening latest news, London Cancer Gynaecology Annual Education Open Meeting, UCLPartners, London, UK, 18 June 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Menon U. Invited Talk: Ovarian screening latest news, London Cancer Gynaecology Annual Education Open Meeting, UCLPartners, London, UK, 18 June 2015
Year(s) Of Engagement Activity 2015
 
Description Menon U. Invited Talk: The UKCTOCS and UKFOCSS trials - what have we learnt so far? 2nd International Ovarian Tumor Analysis Congress (IOTA 2015), 17 Apr 2015, Leuven, Belgium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Menon U. Invited Talk: The UKCTOCS and UKFOCSS trials - what have we learnt so far? 2nd International Ovarian Tumor Analysis Congress (IOTA 2015), 17 Apr 2015, Leuven, Belgium
Year(s) Of Engagement Activity 2015
 
Description Menon U. Invited Talk: UKCTOCS update, RCOG Annual Professional Development Conference, 24 - 26 Nov 2015, London, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Menon U. Invited Talk: UKCTOCS update, RCOG Annual Professional Development Conference, 24 - 26 Nov 2015, London, UK
Year(s) Of Engagement Activity 2015
 
Description Menon U. Invited talk: Mortality outcomes of the UK Ovarian Cancer Screening programme (UKCTOCS), British Society for Gynaecological Imaging Annual Scientific Meeting, RCOG, London, UK, 16th April 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Usha Menon invited talk 'Mortality outcomes of the UK Ovarian Cancer Screening programme (UKCTOCS)' at the British Society for Gynaecological Imaging (BSGI) Annual Scientific Meeting, RCOG, London, UK on 16th April 2016.
Year(s) Of Engagement Activity 2016
 
Description Menon U. Invited talk: Ovarian cancer screening - role of biomarkers, 4th Biomarkers in Diagnoscs, Berlin, Germany, 8th Oct 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Usha Menon invited talk 'Ovarian cancer screening - role of biomarkers' at the 4th Biomarkers in Diagnoscs, Berlin, Germany on 8th Oct 2015.
Year(s) Of Engagement Activity 2015
 
Description Menon U. Invited talk: Ovarian cancer screening - what do we know now?, British Gynaecological Cancer Society Annual Scientific Meeting, The ICC, Birmingham, UK, 12th May 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Usha Menon invited talk 'Ovarian cancer screening - what do we know now?' at the British Gynaecological Cancer Society Annual Scientific Meeting (BGCS 2016), 12th May 2016, The ICC, Birmingham, UK.
Year(s) Of Engagement Activity 2016
 
Description Menon U. Invited talk: Ovarian cancer screening, New Cancer Screening Programmes, Swedish Medical Society, Stockholm, Sweden, 6th October 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Usha Menon Invited talk on 'Ovarian cancer screening, New Cancer Screening Programmes' at Swedish Medical Society, Stockholm, Sweden on 6th October 2016.
Year(s) Of Engagement Activity 2016
 
Description Menon U. Invited talk: Screening for Ovarian Cancer, Biennial Ovarian Cancer Symposium, Singapore, 27th June 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Usha Menon invited talk 'Screening for Ovarian Cancer' at the Biennial Ovarian Cancer Symposium, National University of Singapore, Singapore on 27th June 2014.
Year(s) Of Engagement Activity 2014
 
Description Menon U. Invited talk: The UK Collaborative Trial of Ovarian Cancer Screening - Outcomes, UCL Frontiers of Oncology: Women's Health, Royal College of Physicians, London, UK, 28th Sept 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Usha Menon invited talk 'The UK Collaborative Trial of Ovarian Cancer Screening - Outcomes' at UCL Frontiers of Oncology: Women's Health, Royal College of Physicians, London, UK on 28th Sept 2016.
Year(s) Of Engagement Activity 2016
 
Description Menon U. Invited talk: Update on the UKCTOCS trial: Compliance, performance of MMS & USS arms, stage distribution, After UKCTOCS, Public Messaging on Screening and Early Detection of Ovarian Cancer, Banbury Center, Cold Spring Harbor Laboratory, USA, 8th Feb 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Usha Menon invited talk 'Update on the UKCTOCS trial: Compliance, performance of MMS & USS arms, stage distribution, After UKCTOCS' at the Public Messaging on Screening and Early Detection of Ovarian Cancer, Banbury Center, Cold Spring Harbor Laboratory, USA on 8th Feb 2016.
Year(s) Of Engagement Activity 2016
 
Description Ovarian Cancer Inquiry, All Party Parliamentary Group on Ovarian Cancer, Target Ovarian Cancer, The House of Commons, Westminster, London, UK 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact The All-Party Parliamentary Group (APPG) on Ovarian Cancer was established in 2010 to facilitate greater understanding and awareness of ovarian cancer among parliamentarians. The APPG has focused much of its work on what can be done to improve early diagnosis of ovarian cancer. Prof Menon gave evidence to the panel and answered questions regarding two UK studies - UKCTOCS and UKFOCSS.
APPG commended that two such high-calibre studies into screening for ovarian cancer have taken place although it is disappointing that these have not yet been able to conclude conclusively in favour of a screening programme for either women in the general population or those at a heightened risk of developing ovarian cancer.
The Inquiry welcomed the positive commitment made by Public Health England should final results for the two studies demonstrate a positive impact on mortality, while also noting the potential challenges posed by the need for a suitably trained sonographer workforce. On this basis the APPG on Ovarian Cancer makes the following recommendation: For NHS England and Health Education England to factor a potential increase in demand for sonographers in their workforce planning.
The report was published by Target Ovarian Cancer to coincide with World Ovarian Cancer Day on 8 May 2018.
Year(s) Of Engagement Activity 2018
 
Description Progress with Population Screening for Ovarian Cancer at ICUH Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact *
Year(s) Of Engagement Activity 2013
URL https://www.icuh2014.com
 
Description Research Feedback Event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Supporters
Results and Impact Approximately 150 people attended the meeting which consisted of oral and poster presentations allowing opportunities for networking between charity supporters, trustees and researchers.

members of the public who attended signed up to receive regular newsletters from the charity and also to participate in fund raising events or make donations to the charity
Year(s) Of Engagement Activity 2013
 
Description Sky News interview with Professor Ian Jacobs 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Interview with Sky News into his research into ovarian cancer

*
Year(s) Of Engagement Activity 2014
 
Description Talk at Festival of Public Health Event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Questions and answers afterwards

tbc
Year(s) Of Engagement Activity 2013
 
Description Target Ovarian Cancer presentation - The current states of screening for ovarian cancer 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact *
Year(s) Of Engagement Activity 2014
URL http://www.targetovariancancer.org.uk/news/'ask-experts'-podcast-status-ovarian-cancer-screening
 
Description Thank you card 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact With the help of an artist we designed a card to thank women in UKCTOCS which was posted out to approximately 200,000 participants after the close of screening in the trial. Approximately 30,000 women responded within 3 weeks with positive feedback about the trial's impact on them.

As a consequence of the thank you card the study team obtained health status updates from the participants and change of address notifications which will assist for the mailing out our final study questionnaire. In addition, women had an opportunity to undertake fund raising activity via the charity Eve Appeal.
The project relating to generation of the card was presented as the Institute for Women's health annual meeting as a poster
Year(s) Of Engagement Activity 2012
 
Description UKCTOCS Newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact This is difficult to assess as we have more than 200,000 women in our trial and only a very small fraction wrote in to provide feedback.


Women in UKCTOCS were informed of the trial progress and new developments.
Year(s) Of Engagement Activity 2007