Genetic analyses to test the causal relevance of lipoprotein(a) levels to coronary disease

Lead Research Organisation: University of Cambridge
Department Name: Research Services Division

Abstract

Heart attacks and strokes account for almost 1 in every 2 adult deaths worldwide, and coronary heart disease is the single leading killer in the UK. Major established causes of heart disease include diabetes, smoking, and higher levels of blood pressure and blood cholesterol. If further blood components can be shown to be additional important causes of heart disease, then this should lead to improvements in the prediction and prevention of the disease, exemplified by measurement and modification of blood cholesterol levels.

Lipoprotein(a) (?Lp[a]?) is a very large protein wrapped around a ?bad cholesterol? molecule that may promote narrowing of arteries that precedes heart attacks. Over the past few decades, there have been many reports of correlations between blood levels of Lp(a) and subsequent risk of heart disease. It is not clear from such studies, however, whether Lp(a) concentration is mainly a cause or a consequence of heart disease.

We have proposed a series of large genetic studies in order to help judge whether Lp(a) is likely to have a cause-and-effect relation relationship with heart disease. Because genetic factors that influence blood Lp(a) level are fixed at conception, such genetic information may be used in sufficiently large studies to help distinguish causality from mere correlation.

In particular, we will characterise the genetic, biochemical and other correlates of blood Lp(a) levels in 20,000 European and South Asian people, in whom comprehensive genetic profiling has already been completed. We will use this information to pinpoint the key genetic determinants of blood Lp(a) levels in the same 20,000 people. These key genetic factors will then be assessed in the stored genetic samples of about 30,000 patients with heart disease and of about 70,000 healthy people. Statistical tests for consistency will be done across these databases to help determine whether genetic information supports a causal role for Lp(a) in heart disease.

The findings of this work should provide important scientific insights, helping to prioritise efforts to develop disease prevention strategies against Lp(a) and to interpret findings from ongoing large clinical trials of niacin (a drug that moderately lowers blood levels of Lp[a] and several other blood fats).

Technical Summary

Lipoprotein(a) (Lp[a]), a very large glycoprotein wrapped around an LDL-like particle, has been implicated in coronary heart disease (CHD), but causality remains uncertain. The current proposal involves a series of genetic studies to help test causality by:

(1) assay of Lp(a) levels in 20,000 healthy European and South Asian people in whom genome wide association scans, biochemical profiling and other detailed phenotyping have already been done, enabling powerful and cost-effective characterisation of Lp(a) correlates and distributions;

(2) combination of genome wide and gene?centric approaches in the same 20,000 participants to identify key genetic variants at the LPA gene (the major determinant of Lp[a] levels) that influence circulating levels of Lp(a);

(3) genotyping a relatively small number of key SNPs that show reproducible statistical associations with Lp(a) levels in a total of about 29,000 CHD cases and 69,000 controls in an existing consortium; and

(4) integration of the gene-Lp(a) and gene-CHD data generated in the studies above with data on Lp(a)-CHD associations, such as from the separately funded Emerging Risk Factors Collaboration of 120,000 participants (8500 incident CHD cases) with Lp(a) levels.

Assessment for numerical consistency of these varying sources of data (ie, a ?Mendelian randomisation analysis?) will enable judgement of the likelihood and magnitude of any causal association of Lp(a) concentration with CHD. Findings from the proposed studies should have considerable translational implications for existing drugs (eg, niacin non-specifically lowers Lp[a] levels by about 20%), for the development of new preventative strategies, and for novel mechanistic insights.

Publications

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C Reactive Protein Coronary Heart Disease Genetics Collaboration (CCGC) (2011) Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. in BMJ (Clinical research ed.)

 
Description Wellcome Trust H3Africa
Amount £2,550,000 (GBP)
Funding ID 060743 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2013 
End 12/2017
 
Title Sequencing data on human genomes 
Description As part of an analysis to identify high frequency genetic variants at the population level, we have sequenced whole genomes at low and high coverage from sub-Saharan Africa and South Asia. These data will be publicly available through managed databases. 
Type Of Material Database/Collection of Data/Biological Samples 
Provided To Others? No  
Impact The sequencing data will be publicly available to the scientific community. 
 
Description African Partnership for Chronic Disease Research 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description African Partnership for Chronic Disease Research 
Organisation Makerere University College of Health Sciences
Country Uganda 
Sector Academic/University 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description African Partnership for Chronic Disease Research 
Organisation Medical Research Council (MRC)
Department MRC Centre for Genomics and Global Health
Country United Kingdom 
Sector Academic/University 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description African Partnership for Chronic Disease Research 
Organisation Medical Research Council (MRC)
Department MRC Unit, The Gambia
Country Gambia 
Sector Public 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description African Partnership for Chronic Disease Research 
Organisation Medical Research Council (MRC)
Department Medical Research Council (MRC), MRC/UVRI Unit, Uganda
Country Uganda 
Sector Public 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description African Partnership for Chronic Disease Research 
Organisation Moi University
Department School of Medicine
Country Kenya 
Sector Academic/University 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description African Partnership for Chronic Disease Research 
Organisation National Human Genome Center; Howard University
Country United States 
Sector Academic/University 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description African Partnership for Chronic Disease Research 
Organisation National Institute for Medical Research, Tanzania
Department Mwanza Intervention Trials Unit (MITU)
Country Tanzania, United Republic of 
Sector Public 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description African Partnership for Chronic Disease Research 
Organisation National Institutes of Health (NIH)
Department National Human Genome Research Institute (NHGRI)
Country United States 
Sector Public 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description African Partnership for Chronic Disease Research 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description African Partnership for Chronic Disease Research 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Multiple 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description African Partnership for Chronic Disease Research 
Organisation University of Cape Town
Country South Africa 
Sector Academic/University 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description African Partnership for Chronic Disease Research 
Organisation University of Conakry
Country Guinea 
Sector Academic/University 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description African Partnership for Chronic Disease Research 
Organisation University of Ghana
Department School of Medicine
Country Ghana 
Sector Academic/University 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description African Partnership for Chronic Disease Research 
Organisation University of Ibadan
Country Nigeria 
Sector Academic/University 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description African Partnership for Chronic Disease Research 
Organisation University of KwaZulu-Natal
Country South Africa 
Sector Academic/University 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description African Partnership for Chronic Disease Research 
Organisation University of Nigeria
Department University of Nigeria Teaching Hospital (UNTH) Ituku/Ozalla Enugu
Country Nigeria 
Sector Hospitals 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description African Partnership for Chronic Disease Research 
Organisation University of Oxford
Department Wellcome Trust Centre for Human Genetics
Country United Kingdom 
Sector Academic/University 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description African Partnership for Chronic Disease Research 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description African Partnership for Chronic Disease Research 
Organisation University of Yaoundé
Country Cameroon 
Sector Academic/University 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description African Partnership for Chronic Disease Research 
Organisation University of the Gambia
Country Gambia 
Sector Academic/University 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description African Partnership for Chronic Disease Research 
Organisation University of the Witwatersrand
Country South Africa 
Sector Academic/University 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description African Partnership for Chronic Disease Research 
Organisation Wellcome Trust
Department Malawi-Liverpool Wellcome Trust Clinical Research Programme
Country Malawi 
Sector Charity/Non Profit 
PI Contribution 1. Set-up and coordination of the partnership. 2. Expertise and research capacity in: genetics/genomics of chronic disease, informatics, large-scale analytical pipelines, statistical genetics, epidemiology and public health. 3. Access to high throughput next-generation sequencing and genotyping laboratory and analytical pipelines and infrastructure.
Collaborator Contribution The partnership includes 18 centres from 12 different countries. Expertises range from epidemiology of diabetes and cardiovascular diseases in African populations to population genetics/genomics, bioethics, population-based surveys and interventions. African centres also contribute existing resources and infostructure for sample collection (clinics and field stations) and analyses.
Impact Two successful grant application have resulted so far from this partnership: Wellcome Trust (WT099316MA) Burden, spectrum and aetiology of type 2 diabetes in sub-Saharan Africa 2013-2018 £2,550,000 MRC Research partnership to assess the burden and aetiology of non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) 2013-2018 £885,314 The partnership is also taking part in several ongoing projects including the African Genome Variation project, led by the Wellcome Trust sanger Institute, and a HIV/ART/NCD meta-analysis.
Start Year 2011
 
Description Lp(a) levels in a population from sub-Saharan Africa 
Organisation MRC/UVRI Uganda Research Unit on AIDS
Country Uganda 
Sector Public 
PI Contribution Together with MRC/UVRI, and with independent MRC grant funding we have devised and conducted a large scale study in Uganda--assessing the distribution of cardiometabolic risk factors. Within context of the current MRC grant funding, we aim to examine the distribution of Lp(a) and other risk factors for heart disease in this population.
Collaborator Contribution One of our primary research mandates for the current grant was to the characterise the correlates of Lp(a) levels in different populations using standardised measurements (Objective 1). We originally focused on populations of European and South Asian descent. This collaboration allowed us to extend these studies to populations from sub-Saharan Africa. Importantly, it has been suggested that elevated levels of lipoprotein(a) [Lp(a)] are a risk marker for coronary heart disease in European populations, but not among African Americans. This is despite the observation that African American populatons have both higher Lp(a) levels and higher absolute cardiovascular event rates. There is a paucity of such data in populations from Africa, where the varying genetic background may alter the association between the cognate gene and Lp(a) levels. We aim to compare data across European, Souh Asian and African populations.
Impact We now have data on more than 8,000 study participants from Uganda, which will be compared with data from 20,000 Europeans and 20,000 South Asians. This is a multi-disciplinary collaboration involving clinicians, epidemiologists and geneticists.
Start Year 2010