DPFS Resource Request (University of Glasgow)

Lead Research Organisation: University of Glasgow
Department Name: College of Medical, Veterinary &Life Sci

Abstract

The development of new treatments for a range of diseases requires both an ability to understand the disease as well as an ability to take this understanding and to use it for the development of new therapies. We have been active in this area and have moved, in a number of disease areas, from basic research to therapies which are almost at the point of being of patient benefit. We now wish to develop these therapies further and to take them to the stage at which they will be accepted as being of sufficient value for further clinical trials. To do this we need the help of experts who will be involved in managing these sometimes very complex projects. We have 3 main disease areas that we are interested in: cancer, heart disease and inflammatory diseases such as diseases of joints and lungs. These experts will develop our projects and will ensure that their potential entry into clinical practice is carefully and efficiently handled. In addition, some of the therapeutics we are interested in are experimental and we are also requesting some items of equipment which will be important in helping us to assess the effectiveness of these therapies.

Technical Summary

Cancer, Cardiovascular and Inflammation are the three areas of strategic priority for translational medicine within the University of Glasgow. These represent priority areas for basic research as well as for translational and clinical research and we aim to foster bi-directional bench to bedside and population ethos within our university. As a result of our existing collaborative efforts, we are now at an advanced stage of development of a number of potential therapeutics which show promise in each of these 3 key areas. We believe that with the help of an integrated project management team and strategic advisory group we will be able to expedite the translation of our research findings in each of the above areas into the clinic. We request 3 Translational Research Managers, working in conjunction with a Translational Research Advisory Group, to provide experienced and dedicated project management support for translational projects in each of our three priority areas; to develop and support the interfaces between these areas; to develop and support the interface with researchers in the MRC Social and Public Health Sciences Unit; and to facilitate the basic to translational pipeline within our key thematic areas. In addition, we request small items of capital equipment to be used across translational medicine projects, including Laser Dissection Microscopy, 2 Ultrasound Scanners, a Dimension Xpand Plus Analyser, an Endo-PAT2000 and a Zeiss LSM 5 Exciter Confocal Microscope. The pieces of equipment would be immediately employed for rapid gains thus further enhancing our international competitiveness in key fields.
 
Description Confidence in Concept
Amount £280,000 (GBP)
Funding ID MC_PC_16045 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2017 
End 02/2019
 
Description DCS
Amount £3,323,536 (GBP)
Funding ID G1001147 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description DPFS
Amount £726,292 (GBP)
Funding ID G100791 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
End 12/2015
 
Description Efficacy and Mechanism Evaluation Programme
Amount £563,805 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description MRC Confidence in Concept
Amount £500,000 (GBP)
Funding ID MC-PC-15039 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2016 
End 02/2018
 
Description MRC Confidence in Concept
Amount £500,000 (GBP)
Funding ID MC_PC_13063 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2014 
End 09/2015
 
Description MRC/AstraZeneca Mechanisms of Disease
Amount £481,903 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Proximity to Discovery
Amount £125,000 (GBP)
Funding ID MC_PC_14133 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2015 
End 08/2016
 
Description Proximity to Discovery
Amount £110,000 (GBP)
Funding ID MC_PC_16073 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2017 
End 08/2018
 
Description 1946 Study - novel cardiovascular risk markers 
Organisation University College London
Department MRC Unit for Lifelong Health and Ageing
Country United Kingdom 
Sector Public 
PI Contribution We are conducting novel biomarker assessments in the 1946 study. We are measuring several analytes in over 2200 samples.
Impact Work is ongoing with no outcomes as yet. The collaboration is multi-disciplinary including the MRC Unit, metabolic medicine, cardiovascular and epidemiology.
Start Year 2011
 
Description ALSPAC - utility of biomarkers in adolescent non-alcoholic fatty liver disease 
Organisation University of Bristol
Department MRC Centre for Causal Analyses in Translational Epidemiology
Country United Kingdom 
Sector Public 
PI Contribution The research is investigating the utility of biomarkers for non-alcoholic fatty liver disease in adolescents. We conducted liver function and novel biomarker tests in 17 year olds.
Impact There are no outcomes so far, but all the data on over 3500 adolescents on a range of biomarkers will contribute to several papers of clinical relevance. The collaboration was multi-disciplinary and included biochemistry, metabolic medicine, epidemiology and public health.
Start Year 2009
 
Description BMS Academic Collaboration 
Organisation Bristol-Myers Squibb
Country United States 
Sector Private 
PI Contribution TO explore the role of abatacept in tolerance induction
Impact In progress
Start Year 2010
 
Description BT Cure 
Organisation Leiden University
Country Netherlands 
Sector Academic/University 
PI Contribution WP Leader in IMI consortium
Collaborator Contribution Intellectual partnership and idea promotion
Impact In progress
Start Year 2011
 
Description FP7 Masterswitch 
Organisation University of Zurich
Country Switzerland 
Sector Academic/University 
PI Contribution I am WP leader on this FP7 grant which is exploring the role of innate immune activation in rheumatoid arthritis -aiming to take mechanism to new therapeutics.
Collaborator Contribution Information sharing and technical advice
Impact Not as yet.
Start Year 2009
 
Description SABRE - predictors of cardiometabolic disease in different ethnic groups. 
Organisation Imperial College London
Department National Heart & Lung Institute (NHLI)
Country United Kingdom 
Sector Academic/University 
PI Contribution We conducted biobank analyses incude HBA1c, insulin, and other novel biomarkers on over 2000 samples.
Impact Ongoing work on a variety of biomarkers and outputs include oral presentation at European Association for Study of Diabetes: we anticipate several papers arising from this work. Yes multi-disciplinary including biochemistry; metabolic medicine; epidemiology and public health sciences.
Start Year 2010
 
Description MVLS Industry Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Using various networks several 100 biomedical, life sciences and veterinary professionals from industry, government and public sector organisations were invited the University of Glasgow's College of Medical, Veterinary and Life Sciences first Industry Day. After keynote presentations from Dr Patrick Vallance (GSK) and Dr Ruth McKernan (Pfizer) participants had the opportunity, via speed-dating presentations and poster sessions to learn more about our research capabilities. www.gla.ac.uk/colleges/mvls/industryday/

Non-confidential technical datasheets prepared for the event provide ready-made marketing materials which have been used on numberous occasions post the event to showcase our research capability.
The event raised awareness of the breadth of research capability across our College encouraging new collaborations and alliances to be explored.
Year(s) Of Engagement Activity 2012