Modulation of Staphylococcus epidermidis adhesion and biofilm formation by specific biomaterial surfaces
Lead Research Organisation:
Swansea University
Department Name: Institute of Life Science Medical School
Abstract
Medicine?s tremendous progress in recent decades is closely linked to the ever increasing use of biomaterial implants, that is, artificial devices which are implanted into patients? tissues, such as some types of catheters (or large ?drips?) in blood vessels, artificial joints and heart valves, cardiac pacemakers, artificial intraocular lenses, and shunts in the brain. Infection is a major complication of the use of such devices causing major suffering and mortality for the affected patients, and significant costs for the health care system and society in general. Once the devices become infected it is very difficult to eradicate the infection, and often the devices must be removed again, and further procedures undertaken to replace them. In some cases replacement procedures, as well as the infection itself, carries very high risks to the patient. The organism causing these infections most frequently, namely, Staphylococcus epidermidis, has risen from rare obscurity as a pathogen to be one of the five major causes of health-care associated infection in line with MRSA, Clostridium difficile, and other antibiotic resistant organisms. Staphylococcus epidermidis has a particular propensity to adhere to, or colonise, biomaterial surfaces. Better understanding of the interaction of this bacterium with biomaterial surfaces, and the changes in the properties of the organisms during process is urgently needed. We have recently found that different biomaterials enhance expression of the mechanisms involved in bacterial colonisation in measurably different ways. We seek to better understand these processes, which may lead to the rational development and evaluation of biomaterials less prone to colonisation and infection. The reduction of the number of biomaterial-related infections through these new developments by only a few percent could prevent unnecessary incapacity and sufferings for thousands of patients, not to mention large cost savings.
Technical Summary
Critical to the pathogenesis of biomedical implant-associated infections, most frequently caused by Staphylococcus epidermidis, is the ability of the bacteria to adhere to the biomaterial surface and then form a biofilm, thereby evading the host?s immune system and antibiotics. Contact of S. epidermidis with biomaterial surfaces causes alterations of expression of adhesins and biofilm factors, but these changes are not well characterised, although they are critical in the establishment of infection. Preliminary results from electron micrographs and immunofluorescence analysis indicate that expression of intercellular adhesive properties differ significantly on attachment of S. epidermidis to different biomaterials like titanium or stainless steel. Therefore, we will study expression of factors functional in biofilm accumulation such as the intercellular polysaccharide adhesin (PIA), and proteinaceous intercellular adhesins Aap and Embp. Quantitative changes and alterations in their functional status on three different metal biomaterials will be studied. As additional surface exposed staphylococcal proteins may contribute significantly to the early colonisation phase we will characterise their expression in a systematic way using immunochemical as well as transcriptional analysis with microarray and qRT-PCR methods. The expression of adhesion factors on native and extracellular matrix protein-modified surfaces will be compared. The importance of the observed differences will be confirmed by studying expression patterns of a number of S. epidermidis strains from different forms of device-related infection. Translational applications of this new knowledge may ultimately channel into the rational development and evaluation of biomaterials less prone to colonisation and infection. This application specifically proposes to:
1. Identify and quantify the influence of biomaterial surfaces on adhesion and expression of S. epidermidis adhesins and intercellular adhesive mechanisms (Aims 1-4)
2: Compare S. epidermidis adhesion and expression of adhesins and intercellular adhesive mechanisms on ECM-modified and native biomaterial surfaces (Aim 5)
3: Determine if similar expression patterns are observed in a number of S. epidermidis strains from different forms of prosthetic device infection (Aim 6)
1. Identify and quantify the influence of biomaterial surfaces on adhesion and expression of S. epidermidis adhesins and intercellular adhesive mechanisms (Aims 1-4)
2: Compare S. epidermidis adhesion and expression of adhesins and intercellular adhesive mechanisms on ECM-modified and native biomaterial surfaces (Aim 5)
3: Determine if similar expression patterns are observed in a number of S. epidermidis strains from different forms of prosthetic device infection (Aim 6)
Organisations
- Swansea University, United Kingdom (Lead Research Organisation)
- University of Oxford, United Kingdom (Collaboration)
- Public Health England, Salisbury (Collaboration)
- Southmead Hospital (Collaboration)
- Cardiff & Vale University Health Board, United Kingdom (Collaboration)
- University of Bath, Bath (Collaboration)
- Imperial College London, United Kingdom (Collaboration)
- Singleton Hospital, United Kingdom (Collaboration)
- The Wellcome Trust Sanger Institute (Collaboration)
- Rockefeller University (Collaboration)
- AO Foundation (Collaboration)
- Health and Care Research Wales (Collaboration)
- University of Helsinki, Finland (Collaboration)
- Abertawe Bro Morgannwg University Health Board, Morriston, United Kingdom (Collaboration)
- Public Health Wales NHS Trust, United Kingdom (Collaboration)
- Friedrich Loeffler Institute (Collaboration)
- University Hospital of Wales (Collaboration)
Publications

Aidley J
(2018)
PhasomeIt: an 'omics' approach to cataloguing the potential breadth of phase variation in the genus Campylobacter
in Microbial Genomics

Al-Ishaq R
(2015)
Effects of polysaccharide intercellular adhesin (PIA) in an ex vivo model of whole blood killing and in prosthetic joint infection (PJI): A role for C5a.
in International journal of medical microbiology : IJMM

Atterby C
(2018)
The Potential of Isolation Source to Predict Colonization in Avian Hosts: A Case Study in Campylobacter jejuni Strains From Three Bird Species
in Frontiers in Microbiology

Bayliss S
(2018)
Genomic epidemiology of the commercially important pathogen Renibacterium salmoninarum within the Chilean salmon industry
in Microbial Genomics

Berthenet E
(2019)
Source attribution of Campylobacter jejuni shows variable importance of chicken and ruminants reservoirs in non-invasive and invasive French clinical isolates.
in Scientific reports

Berthenet E
(2018)
A GWAS on Helicobacter pylori strains points to genetic variants associated with gastric cancer risk
in BMC Biology

Christner M
(2010)
The giant extracellular matrix-binding protein of Staphylococcus epidermidis mediates biofilm accumulation and attachment to fibronectin.
in Molecular microbiology


Dunn S
(2018)
Genomic epidemiology of clinical Campylobacter spp. at a single health trust site
in Microbial Genomics

El-Bouri K.
(2012)
Comparison of bacterial identification by MALDI-TOF mass spectrometry and conventional diagnostic microbiology methods: agreement, speed and cost implications
in BRITISH JOURNAL OF BIOMEDICAL SCIENCE
Description | Biomarkers and Clinical Diagnosis |
Amount | £767,247 (GBP) |
Organisation | Academic Expertise for Business (A4B) |
Sector | Public |
Country | United Kingdom |
Start | 06/2013 |
End | 07/2015 |
Description | EU FP7 AMETHYST |
Amount | £430,150 (GBP) |
Organisation | European Commission |
Department | Seventh Framework Programme (FP7) |
Sector | Public |
Country | European Union (EU) |
Start | |
End | 10/2012 |
Description | Generating tools for the molecular epidemiology of Campylobacter coli by next generation genome |
Amount | £120,461 (GBP) |
Organisation | Food Standards Agency (FSA) |
Sector | Public |
Country | United Kingdom |
Start | 06/2013 |
End | 06/2016 |
Description | Medical device related anti-biofilm therapeutics |
Amount | £41,000 (GBP) |
Funding ID | R272/1112 |
Organisation | The Dunhill Medical Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2013 |
End | 08/2014 |
Description | Molecular epidemiology of ESCAPE pathogens in Wales |
Amount | £240,000 (GBP) |
Organisation | Health and Care Research Wales |
Sector | Public |
Country | United Kingdom |
Start | 09/2014 |
End | 09/2017 |
Description | Society of General Microbiology Public Engagement Fund |
Amount | £295 (GBP) |
Organisation | Society of General Microbiology |
Sector | Charity/Non Profit |
Country | European Union (EU) |
Start | 01/2011 |
End | 12/2011 |
Description | TB genomics |
Amount | £3,000 (GBP) |
Organisation | St. David's Medical Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 02/2012 |
End | 02/2014 |
Description | Wales Office for Research and Development (WORD) |
Amount | £133,771 (GBP) |
Organisation | Health and Care Research Wales |
Sector | Public |
Country | United Kingdom |
Start | 01/2010 |
End | 07/2011 |
Title | Bacterial genotyping and phenotyping |
Description | DNA sequencing and microbial phenotyping methods developed as part of this project are now widely used. |
Type Of Material | Biological samples |
Year Produced | 2013 |
Provided To Others? | Yes |
Impact | Swansea servers now host the large scale bacterial genome databases with thousands of genomes. These Mirror databases in Oxford and are a national resource for bacterial population genomics. Swansea servers now host the large scale bacterial genome databases with thousands of genomes. These Mirror databases in Oxford and are a national resource for bacterial population genomics |
URL | http://zoo-talisker.zoo.ox.ac.uk/perl/bigsdb/bigsdb.pl?db=staphylococcus_sheppard |
Title | BIGSdb |
Description | Hosted in Oxford University (Martin Maiden), BIGSdb is a widely used bacterial genome sequence database. Work from this project contributes to the ongoing development of this resource. |
Type Of Material | Database/Collection of data |
Year Produced | 2010 |
Provided To Others? | Yes |
Impact | BIGSdb is used by numerous research groups studied bacterial genomics and epidemiology. |
URL | http://pubmlst.org/software/database/bigsdb/ |
Description | European Staphylococcus collaborations |
Organisation | AO Foundation |
Country | Switzerland |
Sector | Charity/Non Profit |
PI Contribution | The research infrastructure developed in Swansea involves numerous project partners. This includes European Staphylococcus experts including: Prof Edward Feil; Prof Herminie de Lancastre; Prof Stephan Shwarts. The collaborative network also includes colleagues at: The Wellcome Trust Sanger Institute; The Oxford Centre for Human Genetics; Harvard University (US); Imperial College London; University of Helsinki. |
Collaborator Contribution | The research infrastructure developed in Swansea involves numerous project partners. This includes European Staphylococcus experts including: Prof Edward Feil; Prof Herminie de Lancastre; Prof Stephan Shwarts. The collaborative network also includes colleagues at: The Wellcome Trust Sanger Institute; The Oxford Centre for Human Genetics; Harvard University (US); Imperial College London; University of Helsinki. |
Impact | x |
Start Year | 2012 |
Description | European Staphylococcus collaborations |
Organisation | Abertawe Bro Morgannwg University Health Board |
Department | Microbiology Services |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | The research infrastructure developed in Swansea involves numerous project partners. This includes European Staphylococcus experts including: Prof Edward Feil; Prof Herminie de Lancastre; Prof Stephan Shwarts. The collaborative network also includes colleagues at: The Wellcome Trust Sanger Institute; The Oxford Centre for Human Genetics; Harvard University (US); Imperial College London; University of Helsinki. |
Collaborator Contribution | The research infrastructure developed in Swansea involves numerous project partners. This includes European Staphylococcus experts including: Prof Edward Feil; Prof Herminie de Lancastre; Prof Stephan Shwarts. The collaborative network also includes colleagues at: The Wellcome Trust Sanger Institute; The Oxford Centre for Human Genetics; Harvard University (US); Imperial College London; University of Helsinki. |
Impact | x |
Start Year | 2012 |
Description | European Staphylococcus collaborations |
Organisation | Cardiff and Vale University Health Board |
Department | Microbiology Services |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | The research infrastructure developed in Swansea involves numerous project partners. This includes European Staphylococcus experts including: Prof Edward Feil; Prof Herminie de Lancastre; Prof Stephan Shwarts. The collaborative network also includes colleagues at: The Wellcome Trust Sanger Institute; The Oxford Centre for Human Genetics; Harvard University (US); Imperial College London; University of Helsinki. |
Collaborator Contribution | The research infrastructure developed in Swansea involves numerous project partners. This includes European Staphylococcus experts including: Prof Edward Feil; Prof Herminie de Lancastre; Prof Stephan Shwarts. The collaborative network also includes colleagues at: The Wellcome Trust Sanger Institute; The Oxford Centre for Human Genetics; Harvard University (US); Imperial College London; University of Helsinki. |
Impact | x |
Start Year | 2012 |
Description | European Staphylococcus collaborations |
Organisation | Friedrich Loeffler Institute |
Department | Institute of Farm Animal Genetics; Friedrich Loeffler Institut |
Country | Germany |
Sector | Academic/University |
PI Contribution | The research infrastructure developed in Swansea involves numerous project partners. This includes European Staphylococcus experts including: Prof Edward Feil; Prof Herminie de Lancastre; Prof Stephan Shwarts. The collaborative network also includes colleagues at: The Wellcome Trust Sanger Institute; The Oxford Centre for Human Genetics; Harvard University (US); Imperial College London; University of Helsinki. |
Collaborator Contribution | The research infrastructure developed in Swansea involves numerous project partners. This includes European Staphylococcus experts including: Prof Edward Feil; Prof Herminie de Lancastre; Prof Stephan Shwarts. The collaborative network also includes colleagues at: The Wellcome Trust Sanger Institute; The Oxford Centre for Human Genetics; Harvard University (US); Imperial College London; University of Helsinki. |
Impact | x |
Start Year | 2012 |
Description | European Staphylococcus collaborations |
Organisation | Imperial College London |
Department | Faculty of Medicine |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The research infrastructure developed in Swansea involves numerous project partners. This includes European Staphylococcus experts including: Prof Edward Feil; Prof Herminie de Lancastre; Prof Stephan Shwarts. The collaborative network also includes colleagues at: The Wellcome Trust Sanger Institute; The Oxford Centre for Human Genetics; Harvard University (US); Imperial College London; University of Helsinki. |
Collaborator Contribution | The research infrastructure developed in Swansea involves numerous project partners. This includes European Staphylococcus experts including: Prof Edward Feil; Prof Herminie de Lancastre; Prof Stephan Shwarts. The collaborative network also includes colleagues at: The Wellcome Trust Sanger Institute; The Oxford Centre for Human Genetics; Harvard University (US); Imperial College London; University of Helsinki. |
Impact | x |
Start Year | 2012 |
Description | European Staphylococcus collaborations |
Organisation | Rockefeller University |
Department | Laboratory of Microbiology and Infectious Diseases |
Country | United States |
Sector | Academic/University |
PI Contribution | The research infrastructure developed in Swansea involves numerous project partners. This includes European Staphylococcus experts including: Prof Edward Feil; Prof Herminie de Lancastre; Prof Stephan Shwarts. The collaborative network also includes colleagues at: The Wellcome Trust Sanger Institute; The Oxford Centre for Human Genetics; Harvard University (US); Imperial College London; University of Helsinki. |
Collaborator Contribution | The research infrastructure developed in Swansea involves numerous project partners. This includes European Staphylococcus experts including: Prof Edward Feil; Prof Herminie de Lancastre; Prof Stephan Shwarts. The collaborative network also includes colleagues at: The Wellcome Trust Sanger Institute; The Oxford Centre for Human Genetics; Harvard University (US); Imperial College London; University of Helsinki. |
Impact | x |
Start Year | 2012 |
Description | European Staphylococcus collaborations |
Organisation | The Wellcome Trust Sanger Institute |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | The research infrastructure developed in Swansea involves numerous project partners. This includes European Staphylococcus experts including: Prof Edward Feil; Prof Herminie de Lancastre; Prof Stephan Shwarts. The collaborative network also includes colleagues at: The Wellcome Trust Sanger Institute; The Oxford Centre for Human Genetics; Harvard University (US); Imperial College London; University of Helsinki. |
Collaborator Contribution | The research infrastructure developed in Swansea involves numerous project partners. This includes European Staphylococcus experts including: Prof Edward Feil; Prof Herminie de Lancastre; Prof Stephan Shwarts. The collaborative network also includes colleagues at: The Wellcome Trust Sanger Institute; The Oxford Centre for Human Genetics; Harvard University (US); Imperial College London; University of Helsinki. |
Impact | x |
Start Year | 2012 |
Description | European Staphylococcus collaborations |
Organisation | University of Bath |
Department | Department of Biology and Biochemistry |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The research infrastructure developed in Swansea involves numerous project partners. This includes European Staphylococcus experts including: Prof Edward Feil; Prof Herminie de Lancastre; Prof Stephan Shwarts. The collaborative network also includes colleagues at: The Wellcome Trust Sanger Institute; The Oxford Centre for Human Genetics; Harvard University (US); Imperial College London; University of Helsinki. |
Collaborator Contribution | The research infrastructure developed in Swansea involves numerous project partners. This includes European Staphylococcus experts including: Prof Edward Feil; Prof Herminie de Lancastre; Prof Stephan Shwarts. The collaborative network also includes colleagues at: The Wellcome Trust Sanger Institute; The Oxford Centre for Human Genetics; Harvard University (US); Imperial College London; University of Helsinki. |
Impact | x |
Start Year | 2012 |
Description | European Staphylococcus collaborations |
Organisation | University of Helsinki |
Department | Department of Mathematics and Statistics |
Country | Finland |
Sector | Academic/University |
PI Contribution | The research infrastructure developed in Swansea involves numerous project partners. This includes European Staphylococcus experts including: Prof Edward Feil; Prof Herminie de Lancastre; Prof Stephan Shwarts. The collaborative network also includes colleagues at: The Wellcome Trust Sanger Institute; The Oxford Centre for Human Genetics; Harvard University (US); Imperial College London; University of Helsinki. |
Collaborator Contribution | The research infrastructure developed in Swansea involves numerous project partners. This includes European Staphylococcus experts including: Prof Edward Feil; Prof Herminie de Lancastre; Prof Stephan Shwarts. The collaborative network also includes colleagues at: The Wellcome Trust Sanger Institute; The Oxford Centre for Human Genetics; Harvard University (US); Imperial College London; University of Helsinki. |
Impact | x |
Start Year | 2012 |
Description | European Staphylococcus collaborations |
Organisation | University of Oxford |
Department | Wellcome Trust Centre for Human Genetics |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | The research infrastructure developed in Swansea involves numerous project partners. This includes European Staphylococcus experts including: Prof Edward Feil; Prof Herminie de Lancastre; Prof Stephan Shwarts. The collaborative network also includes colleagues at: The Wellcome Trust Sanger Institute; The Oxford Centre for Human Genetics; Harvard University (US); Imperial College London; University of Helsinki. |
Collaborator Contribution | The research infrastructure developed in Swansea involves numerous project partners. This includes European Staphylococcus experts including: Prof Edward Feil; Prof Herminie de Lancastre; Prof Stephan Shwarts. The collaborative network also includes colleagues at: The Wellcome Trust Sanger Institute; The Oxford Centre for Human Genetics; Harvard University (US); Imperial College London; University of Helsinki. |
Impact | x |
Start Year | 2012 |
Description | Microbiology and Infection Translational Research Group |
Organisation | Public Health Wales NHS Trust |
Department | Specialist Antimicrobial Chemotherapy Unit |
Country | United Kingdom |
Sector | Public |
PI Contribution | Several members of the research group were co-applicants of a successful bid for a Microbiology and Infection Translational Research Group in Wales funded by WORD. |
Collaborator Contribution | Made mutually available strain collections and started collaborative research. |
Impact | Project manager has been appointed and set-up of translational research network is commencing. |
Start Year | 2010 |
Description | PHW |
Organisation | Public Health Wales NHS Trust |
Country | United Kingdom |
Sector | Public |
PI Contribution | The collaboration provides the collection of bacterial isolates form the Singleton (Swansea) and Heath (Cardiff) hospitals, facilitated by an honorary clinical scientist position held by Sheppard. Analysis from this study is informing clinical microbiologists within the hospitals. |
Collaborator Contribution | Partners provide bacterial isolates. |
Impact | This collaboration has provided isolates for papers detailed in the publications section. |
Start Year | 2012 |
Description | Public Health Pathogen Genomics |
Organisation | Health and Care Research Wales |
Country | United Kingdom |
Sector | Public |
PI Contribution | Sequencing and assembly of bacterial pathogen genomes. |
Collaborator Contribution | Provision of samples. |
Impact | x |
Start Year | 2013 |
Description | Public Health Pathogen Genomics |
Organisation | Public Health England |
Country | United Kingdom |
Sector | Public |
PI Contribution | Sequencing and assembly of bacterial pathogen genomes. |
Collaborator Contribution | Provision of samples. |
Impact | x |
Start Year | 2013 |
Description | Public Health Pathogen Genomics |
Organisation | Public Health Wales NHS Trust |
Country | United Kingdom |
Sector | Public |
PI Contribution | Sequencing and assembly of bacterial pathogen genomes. |
Collaborator Contribution | Provision of samples. |
Impact | x |
Start Year | 2013 |
Description | Public Health Pathogen Genomics |
Organisation | Singleton Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Sequencing and assembly of bacterial pathogen genomes. |
Collaborator Contribution | Provision of samples. |
Impact | x |
Start Year | 2013 |
Description | Public Health Pathogen Genomics |
Organisation | Southmead Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Sequencing and assembly of bacterial pathogen genomes. |
Collaborator Contribution | Provision of samples. |
Impact | x |
Start Year | 2013 |
Description | Public Health Pathogen Genomics |
Organisation | University Hospital of Wales |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Sequencing and assembly of bacterial pathogen genomes. |
Collaborator Contribution | Provision of samples. |
Impact | x |
Start Year | 2013 |
Description | The Oxford Centre for Human Genetics |
Organisation | University of Oxford |
Department | Oxford Genomics Centre |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Development of analysis piplines and databases for investigating bacterial evolution, ecology and epidemiology. |
Collaborator Contribution | The partners carried out genome sequencing of bacterial isolates. |
Impact | The increasing availability of hundreds of whole bacterial genomes provides opportunities for enhanced understanding of bacterial epidemiology and the genes and alleles responsible for important phenotypes and how they evolved. Numerous isolates were sequenced from human infection, farm animals, and retail food, in association with this project and isolate records were archived in BIGSdb: http://zoo-talisker.zoo.ox.ac.uk/perl/bigsdb/bigsdb.pl?db=campy_maiden Building on this platform we developed a gene-by-gene whole genome MLST approach for investigating the genetic basis of phenotypes in diverse bacteria includig E.. coli, Staphylococcus and Campylobacter. Further developing these pipelines to include non-homologous sequence variation in genes that are differentially present in the population, we established a comparative genomics approach that simultaneously approximates core and accessory genome variation in pathogen populations. The number of accessory genes increases with the number of isolates but, as an example, for 7 published Campylobacter jejuni and Campylobacter coli genomes the reference pan-genome comprised 3,933 loci with 1,035 cores genes ubiquitous in the isolates and accounting for 59% of the genes in each isolate (average genome size of 1.68 Mb). A total of 21 genes were present only in C. coli and 27 only in C. jejuni, providing information about functional differences associated with species and novel epidemiological markers for population genomic analyses. Our GWAS pipelines developed for this project are now widely used and the GERM stochastic evolutionary model will be released in a manuscript currently in review. |
Start Year | 2012 |
Description | Wellcome Trust Sanger Institute |
Organisation | The Wellcome Trust Sanger Institute |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | Sequecing at the Wellcome Trust Sanger Centre has contributed to this project. |
Collaborator Contribution | Collaboration has resulted in the development of piplines for analysis of bacterial genomes and research findings relating to pathogen ecology, epidemiology and evolution |
Impact | Several publications have been facilitated by this collaboration. |
Start Year | 2006 |
Description | GwyddonLe @ Urdd Eisteddfod |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Schools |
Results and Impact | 15,000 children, young people and adults visited the exhibition over the week to see and exhibition on DNA Aim is to get children and young people interested in science. |
Year(s) Of Engagement Activity | 2014 |
Description | Interallied Confederation of Medical Reserve Officers, NATO |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | Yes |
Geographic Reach | International |
Primary Audience | Health professionals |
Results and Impact | More than 100 medical reserve officers and active medical officers from many NATO partner countries attended a meeting at NATO Headquarters, Brussels, 11th February 2011. Experts from various academic and practical medical fields discussed the impact of antibiotic resistance on activities of medial reserve officers and active medical officers acitivities. Raised awareness for problems of antimicrobial resistance in casualties of military conflicts and major catastrophes. |
Year(s) Of Engagement Activity | 2011 |
Description | National Eisteddfod 2010, Ebbw Vale, Wales |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | More than 50 peaople attended the Swansea University Stall at Eisteddfod leaving informed about our activities and research programs. Future students became aware of Swansea University Science Degrees. |
Year(s) Of Engagement Activity | 2010 |
Description | National Eisteddfod 2011, Wrexham, Wales |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | More than 50 peaople attended the Swansea University Stall at Eisteddfod leaving informed about our activities and research programs. Future students became aware of Swansea University Science Degrees. |
Year(s) Of Engagement Activity | 2011 |
Description | Poster presentation at ECCMID 2013 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Type Of Presentation | Poster Presentation |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Harris LG, Jeeves, R, Rohde H, Mack D, Sheppard, SK (2013). Staphylococcus epidermidis biofilm formation on indwelling medical devices. ECCMID April 2013, Berlin, Germany. Harris LG, Jeeves, R, Rohde H, Mack D, Sheppard, SK (2013). Staphylococcus epidermidis biofilm formation on indwelling medical devices. Welsh Microbiology Association PanCeltic meeting, Cardiff, UK Networking opportunity |
Year(s) Of Engagement Activity | 2013 |
Description | Presentation at StaphGBI 2013 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Type Of Presentation | Paper Presentation |
Geographic Reach | National |
Primary Audience | Participants in your research and patient groups |
Results and Impact | Llinos G Harris gave a presentation on her current project at StaphGBI 2013, Dublin Ireland, 5-6 September. Population genomics of Staphylococcus epidermidis Llinos G.Harris1, Ben Pascoe1, Holger Rohde2, Dietrich Mack3, Stefan Schwarz4, Herminia de Lancastre5,6, Maria Miragaia4, Joana Rolo4, Rory Bowden6, Sam Sheppard1 Good response to presentation, with interest in collaborations with others in the field |
Year(s) Of Engagement Activity | 2013 |
Description | School Hand Hygiene Demonstration |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | Class of 25 year 6 pupils participated in hand hygiene demonstration including short talk on general microbiology and hygiene. Raising awareness amongst pupils about science and microbiology in particular. |
Year(s) Of Engagement Activity | 2011 |
Description | Talk at Staph GBI2011 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Type Of Presentation | Paper Presentation |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Jeeves R, Harris LG, Mack D. Prevalence of collagen binding factors in clinical isolates of Staphylococcus epidermidis. Staph GBI, September 2011 Edinburgh, UK Networking with peers |
Year(s) Of Engagement Activity | 2011 |
Description | Urdd Eisteddfod (Youth Eisteddfod), Pembrokeshire, Wales |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Type Of Presentation | Workshop Facilitator |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | 15,000 children, young people and adults visited the exhibition over the week to see and exhibition on DNA Aim is to get children and young people interested in science. |
Year(s) Of Engagement Activity | 2013 |
Description | Urdd Eisteddfod (Youth Eisteddfod), Swansea, Wales |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Schools |
Results and Impact | More than 13000 visitors became exposed to basic microbiology and importance of hand hygiene in healthcare and beyond. Children were made aware and became engaged in science |
Year(s) Of Engagement Activity | 2011 |