Tuberculosis Drug discovery-UK (TBD-UK)

Lead Research Organisation: University of St Andrews
Department Name: Sch of Medicine

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

N/A

Publications

10 25 50

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Abuhammad A (2014) Exploration of piperidinols as potential antitubercular agents. in Molecules (Basel, Switzerland)

 
Title A short film launched to commemorate World TB Day 
Description a short film was produced and launched at the World TB Summit in London to commemorate the World TB Day in 2014 
Type Of Art Film/Video/Animation 
Year Produced 2014 
Impact enhanced public engagement and understanding in TB control, education and laboratory research. 
URL http://www.youtube.com/watch?v=gvvvTM__GFI
 
Description Engaging local MP and a Member of House of Lords in TB control
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
 
Description Input to the APPG on Global Tuberculosis call for evidence
Geographic Reach Multiple continents/international 
Policy Influence Type Gave evidence to a government review
 
Description Mentoring Session at INTERNATIONAL UNION on Antibitic Resistance in TB
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
URL http://www.stoptb.org/assets/documents/
 
Description EU Innovative Medicines Initiative
Amount £5,902,837 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 03/2012 
End 02/2017
 
Description European Respiratory Society Short-term Research Fellowship
Amount £10,000 (GBP)
Organisation European Respiratory Society (ERS) 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2016 
End 03/2017
 
Description MRC New Investigators Research Grant
Amount £600,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2009 
End 09/2012
 
Description MRC Research Grant
Amount £505,280 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2010 
End 05/2013
 
Description MRC Research Grant
Amount £495,902 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2010 
End 08/2013
 
Description PreDiCT-TB
Amount £1,000,000 (GBP)
Funding ID 115337 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 03/2012 
End 03/2017
 
Description Scottish Universities Life Science Alliance (SULSA)/Biotechnology and Biological Sciences Research Council (BBSRC) (Bioscape with SULSA and Helpbery Therapeutics PLC)
Amount £87,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2011 
End 12/2014
 
Title GlgE target 
Description Critical target for M. tuberculosis drug discovery identified 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2010 
Provided To Others? Yes  
Impact This enables a new approach to discover new TB drugs 
 
Title In-vivo models of drug evaluation 
Description Mouse, guinea pig and primate models developed for new compound evaluation, 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact Critical assessment models (previously unavailable) ready for use by TB drug discovery researchers. 
 
Title Mur ligase assay 
Description Assay for screening of compounds. 
Type Of Material Technology assay or reagent 
Year Produced 2009 
Provided To Others? Yes  
Impact Novel inhibitors identified 
 
Title X-ray crystal structures 
Description X-ray crystal structures of Mur ligases deposited in protein crystal databank with codes 2XW7, 2WTZ, 2XJA 
Type Of Material Database/Collection of Data/Biological Samples 
Year Produced 2009 
Provided To Others? Yes  
Impact Has enabled structure based design of inhibitors 
URL http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?uid=2XW7
 
Description Computational Biology (Bioinformatics), ISMB 
Organisation Birkbeck, University of London
Department Department of Biological Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution we supplied the structural information of ATP dependent MurE ligase from M. tuberculosis and the structures of MurE ligase inhibitors and theirs analogues.
Collaborator Contribution Supervised a PhD student in my group on molecular docking of M. tuberculosis MurE inhibitors.
Impact An interdisciplinary collaboration between computational biology and molecular microbiology generated an original research article (published): Guzman. J-D.; Wube, A.; Evangelopoulos, D.; Gupta, A.; Hüfner, A.; Basavannacharya, C.; Raman, M. M.; Thomaschitz, C.; Bauer, R.; McHugh, T.D.; Nobeli, I.; Prieto, J. M.; Gibbons, S.; Bucar, F.; and Bhakta, S. (2011) Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics. J. Antimicrob. Chemotherapy 66(8):1766-72.
Start Year 2010
 
Description Inhibitors of Cell wall PG (Med Chem) 
Organisation University College London
Department Department of Chemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution evaluation of the biological properties of the novel compounds against the whole mycobacterial cell as well as against the target enzymes (ATP dependent mur ligases). Currently supervising an interdisciplinary PhD student. A joint UK patent application and an original research article are under review.
Collaborator Contribution Synthesized novel derivatives (more than 100) of aporphine alkaloids as antituberculars.
Impact An interdisciplinary collaboration in between medicinal chemistry, molecular microbiology and chemical biology. Resulted in successful joint supervision of one PhD student, two post-graduate project students, three original research articles and a joint patent application.
Start Year 2011
 
Description NCEs and new formulations to tackle MDR-TB_India 
Organisation Institute of Chemical Technology (ICT)
Country India 
Sector Academic/University 
PI Contribution Comprehensive evaluation of biological properties of pure natural product compounds against whole mycobacterial cell, drug efflux mechanisms and biofilm formation as well as against the target enzymes (such as ATP dependent mur ligases, Muerin peptide ligase, Arylamine N-acetyltransferase, Oxidoreductases from M. tuberculosis).
Collaborator Contribution Generated novel chemical entities and pharmaceutical formulations for testing their anti-TB properties and investigating modes of action
Impact An interdisciplinary collaboration between pharmaceutical science and molecular microbiology & biochemistry. A joint split-site commonwealth proposal application is currently under review.
Start Year 2013
 
Description Natural Product Chemistry UCL-SOP 
Organisation University College London
Department School of Pharmacy
Country United Kingdom 
Sector Academic/University 
PI Contribution evaluation of the biological properties of the crude extracts, partially purified fractions, pure natural product compounds against the whole mycobacterial cell as well as against the target enzymes (ATP dependent mur ligases). Jointly supervised two interdisciplinary Bloomsbury PhD students and currently supervising two international (Govt funded) PhD students. Generated 9 joint original research publications, 1 review article and a few others under preparation.
Collaborator Contribution training and advice on extraction, purification and charaterisation of natural products. Contributing to a library of natural products inhibitors for a comprehensive biological evaluation.
Impact An interdisciplinary collaboration in between natural product chemistry, medicinal chemistry and molecular microbiology: Original research articles: 1. Guzman, J.D.; Mortazavi, P.N.; Munshi, T.; Evangelopoulos, D.; McHugh, T.D.; Gibbons, S.; Malkinson, J. and Bhakta, S. (2014) 2-Hydroxy-substituted cinnamic acids and acetanilides are selective growth inhibitors of Mycobacterium tuberculosis. ChemMedComm 5 (1) 47 - 50. 2. Shiu WK, Malkinson JP, Rahman MM, Curry J, Stapleton P, Gunaratnam M, Neidle S, Mushtaq S, Warner M, Livermore DM, Evangelopoulos D, Basavannacharya C, Bhakta, S., Schindler BD, Seo SM, Coleman D, Kaatz GW, Gibbons S. (2013) A new plant-derived antibacterial is an inhibitor of efflux pumps in Staphylococcus aureus. Int J Antimicrob Agents. 42(6):513-8. 3. Guzman JD, Evangelopoulos D, Gupta A, Birchall K, Mwaigwisya S, Saxty B, McHugh TD, Gibbons S, Malkinson J, Bhakta S.* (2013) Antitubercular specific activity of ibuprofen and the other 2-arylpropanoic acids using the HT-SPOTi whole-cell phenotypic assay. BMJ Open, 3(6). 4. Guzman JD, Evangelopoulos D, Gupta A, Prieto JM, Gibbons S. and Bhakta S. (2013) Antimycobacterials from Lovage Root (Ligusticum officinale Koch). Phytotherapy Research, 27(7):993-8. 5. Wube, A.; Guzman, J.D.; Hüfner, A.; Hochfellner, C.; Blunder, M.; Bauer, R.; Gibbons, S.; Bhakta, S. and Bucar, F. (2012) Synthesis and biological evaluation of a new series of N-alkyl-2-alkynyl-4-(1H)-quinolones. Molecules 17(7):8217-40.1. 6. Osman, K., Evangelopoulos, D., Basavannacharya, C., Gupta, A., McHugh, T.D., Bhakta, S. and Gibbons, S. (2012) An antibacterial from Hypericum acmosepalum inhibits ATP dependent MurE ligase from Mycobacterium tuberculosis. Int. J. Antimicrob. Agents. 39(2):124-9. 7. Guzman, J.D., Wube, A., Evangelopoulos, D., Gupta, A., Hüfner, A., Basavannacharya, C., Rahman, M.M., Thomaschitz, C., Bauer, R., McHugh, T.D., Nobeli, I., Prieto, J.M., Gibbons, S., Bucar, F.¶ and Bhakta, S.¶* (2011) Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics. J. Antimicrob. Chemotherapy 66(8):1766-72. (¶ equal contribution). 8. Guzman, J.D.; Gupta, A.; Evangelopoulos, D.; Basavannacharya, C.; Pabon, L.C.; Plazas, E.A.; Muñoz, D.R.; Delgado, W.A.; Cuca, L.E.; Ribon, W.; Gibbons, S. and Bhakta, S.* (2010) Anti-tubercular screening of natural products from Colombian plants: 3-5 methoxy nordomesticine, an inhibitor of MurE ligase of Mycobacterium tuberculosis. J. Antimicrob. Chemotherapy 65(10), 2101-7. 9. O'Donnell, G., Poeschl, R., Zimhony, O., Gunaratnam, M., Moreira, J.B., Neidle, S., Evangelopoulos, D., Bhakta, S., Malkinson, J.P., Boshoff, H.I., Lenaerts, A. & Gibbons, S. (2009). Bioactive pyridine-N-oxide disulfides from Allium stipitatum. J Nat Prod. 72(3), 360-5. Review Article: 1. Guzman, J.D.; Gupta, A.; Bucar, F.; Gibbons, S. and Bhakta, S. (2012) Anti-mycobacterials from natural sources: ancient times, antibiotic era and novel scaffolds. Frontiers in Bioscience 17, 1861-1881.
Start Year 2007
 
Description Natural Product Chemistry_Austria (EU) 
Organisation Medical University of Graz
Department Pharmacognosie Graz
Country Austria 
Sector Academic/University 
PI Contribution Comprehensive evaluation of the biological properties of pure natural product compounds against the whole mycobacterial cell, drug efflux mechanisms and biofilm formation as well as against the target enzymes (ATP dependent mur ligases). Generated three joint research publications, a review article and a few others in preparation.
Collaborator Contribution Extract, fractionate, purify, semi-synthesize natural product inhibitors against whole cell mycobacteria as well as the target enzymes for validation.
Impact A multi-disciplinary international collaboration (Natural Product Chemistry & Molecular Microbiology) generated the following outputs/ outcomes: Original Research Articles: 1. Wube, A.; Guzman, J.D.; Hüfner, A.; Hochfellner, C.; Blunder, M.; Bauer, R.; Gibbons, S.; Bhakta, S. and Bucar, F. (2012) Synthesis and biological evaluation of a new series of N-alkyl-2-alkynyl-4-(1H)-quinolones. Molecules 17(7):8217-40. 2. Guzman. J-D.; Wube, A.; Evangelopoulos, D.; Gupta, A.; Hüfner, A.; Basavannacharya, C.; Raman, M. M.; Thomaschitz, C.; Bauer, R.; McHugh, T.D.; Nobeli, I.; Prieto, J. M.; Gibbons, S.; Bucar, F.; and Bhakta, S.* (2011) Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics. J. Antimicrob. Chemotherapy 66(8):1766-72. 3. Wube, A.; Guzman, J.D.; Hüfner, A.; Hochfellner, C.; Blunder, M.; Bauer, R.; Gibbons, S.; Bhakta, S. and Bucar, F. (2012) Synthesis and biological evaluation of a new series of N-alkyl-2-alkynyl-4-(1H)-quinolones. Molecules 17(7):8217-40. Review Article: Guzman, J.D.; Gupta, A.; Bucar, F.; Gibbons, S. and Bhakta, S.* (2012) Anti-mycobacterials from natural sources: ancient times, antibiotic era and novel scaffolds. Frontiers in Bioscience 17, 1861-1881. Joint Research Grant applications (successful): 1. Austrian Science Fund (FWF) 2012 - 2015 (€311K) Co-Apl [4-(1H)-Quinolone derivatives as new antibacterial drug-leads. Austrian Science Fund (FWF), EU] 2. Austrian Science Fund (FWF) 2008 - 2011 (€250K) Co-Apl [The evaluation of 4(1H)-quinolone derivatives as new anti-mycobacterial drug-leads. Austrian Science Fund (FWF): EU project P21152-B18]
Start Year 2008
 
Description New antituberculars with novel MoA_Durham 
Organisation Durham University
Country United Kingdom 
Sector Academic/University 
PI Contribution Comprehensive evaluation of the biological properties of pure natural product compounds against the whole mycobacterial cell, drug efflux mechanisms and biofilm formation as well as against the target enzymes (ATP dependent mur ligases, N-acetyl transferase, Oxido-reductases). Generated three joint research publications. One review article and a few other research articles are in preparation.
Collaborator Contribution Extract, fractionate, purify, semi-synthesize as well as design natural product inhibitors against target enzymes as well as against whole cell phenotype for validation.
Impact An interdisciplinary academic research collaboration (Natural Product Chemistry, Computational Biology & Molecular Microbiology) generated original research articles and a successful small research grant. One review article is currently in preparation Original Research Articles: 1. Kottakota SK, Benton M, Evangelopoulos D, Guzman JD, Bhakta S, McHugh TD, Gray M, Groundwater PW, Marrs EC, Perry JD and Harburn JJ. (2012) Versatile routes to marine sponge metabolites through benzylidene rhodanines. Org Lett.;14(24):6310-3. 2. Kottakota, S.K.; Evangelopoulos, D.; Alnimr, A.; Bhakta, S.; McHugh, T.D.; Gray, M.; Groundwater, P.W.; Marrs, E.C.L.; Perry, J.D.; Spilling, C.D. and Harburn, J.J. (2012) Synthesis and biological evaluation of Purpurealidin E-derived marine sponge metabolites: Aplysamine-2, Aplyzanzine A, Suberedamines A,B and Anomoian A. J. Nat Prod. 75(6):1090-101.
Start Year 2011
 
Description Novel nano-particulate formulations to tackle MDR-TB_Malaysia 
Organisation Putra Malaysia University
Country Malaysia 
Sector Academic/University 
PI Contribution Comprehensive evaluation of biological properties of novel nano-particulate formulations against mycobacterial whole-cell, drug efflux mechanisms and biofilm inhibitions and a panel of endogenous targets.
Collaborator Contribution Generated novel pharmaceutical formulations for testing their anti-TB properties and investigating anti-mycobacterial modes of action.
Impact an original research article and an international research grant application are currently in preparation.
Start Year 2016
 
Description Reversing antimicrobial resistance in TB 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Whole-cell phenotypic evaluation of novel chemical entities and target-based evaluation against recombinant proteins from Mycobacterium tuberculosis.
Collaborator Contribution Synthesis of novel chemical entities and their analogues.
Impact Two research articles published. One patent application submitted.
Start Year 2013
 
Description Structural Biology, Birkbeck 
Organisation Birkbeck, University of London
Department Department of Biological Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution significant intellectual input into our common research interest in cell wall peptidoglycan biosynthesis, degradation and recycling in Mycobacterium tuberculosis; Supervised three PhD Students (awarded PhDs in between 2010 and 2013) worked on structural and functional characterisation of mycobacterial proteins. Generated four original research articles and a few others are in preparation.
Collaborator Contribution Training and advice on setting crystallisation trials and solving X-Ray diffraction data for 3D structural elucidation of mycobacterial proteins
Impact An interdisciplinary collaboration in between Structural Biology and Molecular Microbiology: Original Research Articles: 1. Basavannacharya, C., Robertson, G., Munshi, T., Keep, N.H. & Bhakta, S. (2010). ATP-dependent MurE ligase in Mycobacterium tuberculosis: biochemical and structural characterisation. Tuberculosis (Edinb) 90(1), 16-24. 2. Basavannacharya, C., Moody, P. R., Munshi, T., Cronin, N., Keep, N. H. & Bhakta, S. (2010). Roles of amino acid residues essential for the enzyme activity of MurE of Mycobacterium tuberculosis identified. Protein & Cell 1(10)(accepted in press; featured as cover page article) 3. Evangelopoulos D, Cronin N, Daviter T, Sim E, Keep NH and Bhakta S. (2011) Characterization of an oxidoreductase from the arylamine N-acetyltransferase operon in Mycobacterium smegmatis. FEBS J. 278(24):4824-32. 4. Munshi, T.; Gupta, A.; Guzman, J. D.; Evangelopoulos, D.; Gibbons, S.; Keep, N.H. and Bhakta, S.* (2013) Characterisation of ATP-Dependent Mur Ligases Involved in the Biogenesis of Cell Wall Peptidoglycan in Mycobacterium tuberculosis. PloS ONE 8(3): e60143. doi:10.1371/journal.pone.0060143
Start Year 2006
 
Description Substrates and analogues of cellwall-PG enzymes 
Organisation University College London
Department School of Pharmacy
Country United Kingdom 
Sector Academic/University 
PI Contribution assaying the activity and inhibition of substrates and substrate analogues against ATP-dependent Mur ligases and Murein peptide ligases from bacteria.
Collaborator Contribution Synthesizing substrates and substrate analogues (using solid phase peptide synthesis)
Impact An interdisciplinary collaboration in between synthetic chemistry and molecular microbiology. A PhD student is currently under joint supervision and generated one review article and one research article currently in preparation.
Start Year 2011
 
Description TB Alliance (Global Alliance for TB Drug Development) 
Organisation The Global Alliance for TB Drug Development
Country Global 
Sector Private 
PI Contribution As above
Collaborator Contribution The Alliance facilitated key in-vitro assessment of ATC compounds to address specific MRC DPFS panel requests. They have assisted Deputy Chair TBD-UK in the construction of the TBD-UK Blueprint which now serves as a guide for the development of all UK research. They are working with Deputy Chair on the creation of a target product profile for the ATCs and other TB drugs.
Impact As above
Start Year 2009
 
Description TB Drug Discovery UK (TBD-UK) 
Organisation University of St Andrews
Department TBD-UK, Tuberculosis drug discovery consortium
Country United Kingdom 
Sector Academic/University 
PI Contribution As above
Collaborator Contribution Coordinating research, identifying new research partners, addressing key research questions, developing collaborations and making policy change in the research area.
Impact As above
Start Year 2009
 
Description Traditional herbs and new antibiotic_Strathclyde 
Organisation University of Strathclyde
Department Department of Physics
Country United Kingdom 
Sector Academic/University 
PI Contribution Bioassay guided whole-cell phenotypic and genotypic evaluation of natural products (crude extracts, partially purified fractions and purified molecules).
Collaborator Contribution provide natural product inhibitors (crude extracts , partially purified fractions and pure compounds) for bioassay guided evaluation against a panel of bacterial pathogens.
Impact This is an interdisciplinary collaboration between traditional herbal natural products and microbiology. Generated one original research article and one article in preparation. In addition, a joint cross-council research grant application (submitted and under review). Original Research Article: 1. Zhao J, Evangelopoulos D, Bhakta S, Gray AI and Seidel V. (2014) Antitubercular activity of Arctium lappa and Tussilago farfara extracts and constituents. J Ethnopharmacol.;155(1):796-800.
Start Year 2011
 
Description UK Coalition to Stop TB 
Organisation Government of the UK
Country United Kingdom 
Sector Public 
PI Contribution New collaboration previously not undertaken by TB researchers in the past. TBD-UK Chair and Deputy Chair sit on steering group and will be advising APPG TB and other government advisory bodies and government departments on roles, needs and contributions to be made from UK TB researchers in drug discovery.
Impact As above
Start Year 2010
 
Description Workshop CSIR Nanomedicine Platform for Infectious Diseases of Poverty 
Organisation Council of Scientific and Industrial Research (CSIR)
Country South Africa 
Sector Academic/University 
PI Contribution Engaged as research group leader to deliver CSIR workshop under umbrella of knowledge exchange
Impact Workshop to be held March 2011. Knowledge exchange
Start Year 2010
 
Title Whole cell screening of inhibitors against the growth of mycobacteria (HT-SPOTi) 
Description A solid culture based whole cell screening assay (HT-SPOTi; 24, 48 & 96 well format) to test libraries of inhibitors against the slow growing mycobacteria including Mycobacterium aurum and Mycobacterium tuberculosis. 
IP Reference  
Protection Protection not required
Year Protection Granted 2012
Licensed No
Impact Availability of this whole cell screening assay is highly beneficial for TB inihibitor screening purposes. A large number of academic & industrial research collaborations to be established on the basis of this facility.
 
Title Identification and development of new ATC class of antitubercular agents 
Description The ATCs are a new class of anti-tubercular and the first new drug output of TBD-UK collaboration grant. In vitro activity (intra and extra cellular) have been evaluated, toxicity and selectivity evaluated and routes of metabolism identified in vitro. This work was initially funded in part from the Wellcome trust. Other available sources of funding have been utilised on a "good will and collaborative" nature. 
Type Therapeutic Intervention - Drug
Current Stage Of Development Initial development
Year Development Stage Completed 2009
Development Status Actively seeking support
Impact This has proved that the collaboration grant network can lead to real outcomes. The development of this program and recent invitation to full stage application for an MRC DPFS grant has also facilitated the construction of the TB drug discovery and development blue print which is now beign used to guide and coordinate all UK TB reserach in the UK. The development of the DPFS application has also resulted in strong links with the Global TB Alliance for Drug Development and the formation of specific TB drug target product profile (TPP). This may be used to support other outcomes from the collaboration grant. Importantly, this critical activity was not engaged collaboration grant pre-funding 
 
Title Natural product formulation - Pelargonium-derived stimulators of macrophage function 
Description This is a natural product based formulation that activates macrophages under bacterial infection and thus enables the reduction of infection. 
Type Therapeutic Intervention - Drug
Current Stage Of Development Initial development
Year Development Stage Completed 2009
Development Status Under active development/distribution
Impact This enables a new methodology and approach to be investigated. 
 
Description Article in Microbiology Today 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Participants in your research and patient groups
Results and Impact Article "Tuberculosis: forgotten not gone" in Microbiology Today the House Journal of SOciety of General Microbiology which is made available to microbiologists internationally but, importantly given to schools

No notable impacts
Year(s) Of Engagement Activity 2011
 
Description Birkbeck School of Science Week 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Film screening and panel discussion: Tackling antibiotic resistance and the rise of superbugs at Birkbeck Cinema, 43 Gordon Square, London, WC1H 0PD
Antibiotics were first mass-produced in the 1940s and their ability to fight and kill bacteria revolutionized medicine and profoundly impacted everything from agriculture to war. After less than 80 years, however, these miracle drugs are failing. Resistant infections kill hundreds of thousands of people around the world each year and there are now dozens of so-called Superbugs each with its own challenges and costs. How did this happen? Using microscopic footage, harrowing personal stories, and expert insights, Resistance clarifies the problem of antibiotic resistance, how we got to this point, and what we can do to turn the tide.
Year(s) Of Engagement Activity 2017
URL http://www.bbk.ac.uk/science/about-us/events/science-week/
 
Description Evidence to the All Party Parliamentary Committee for tuberculosis 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Advice was given of the importance of support for further research tuberculosis drug development

Further invitations to APPGTB have been made
Year(s) Of Engagement Activity 2010,2011
 
Description Higher Education Workshop (Ealing) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Organisation of a Higher Education workshop focusing on "Extensively drug resistant Tuberculosis (XDR-TB): cure for today or tomorrow)". This included the publising of an article in the London Sharad Utsav 2009 brochure (5000 copies printed)

Increased awareness of the issue of TB and the work of TBD-UK
Year(s) Of Engagement Activity 2009
 
Description I'm a Scientist: get me out of here 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Students from schools across the country were able to log on and ask questions on any particular areas of the scientists' research (or life) that they were curious about, then vote for their favourite scientists to win a prize. SB took part in the initiative to engage young people in science, and to give them a taste of the day-to-day life of a scientist.
Year(s) Of Engagement Activity 2017
URL http://blogs.bbk.ac.uk/bbkcomments/2017/06/26/im-a-scientist-get-me-out-of-here/
 
Description Social Media Public Engagement 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact 620 people like the webpage and follow the posts, posts related to TB research and outreach activities reach about 1500 people every week.
Year(s) Of Engagement Activity 2015,2016,2017
URL https://www.facebook.com/TBrnotTB/
 
Description TBD-UK Website Development 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Development of the TBD-UK website to raise awareness of the research that UK TB researchers in drug discovery and developmen undertaken. Secure area also developed to enable researchers to share key articles and work.

Development of strong links with other TB focused organisations (such as Stop TB, UK Coalition to Stop TB, TB Alert and the APPG.
Continued increase in website visits with approx 300-400 hits per month and a 65% new hit rate.
Year(s) Of Engagement Activity 2009,2010