Development of a Methodology Hub for the island of Ireland

Lead Research Organisation: Queen's University of Belfast
Department Name: Centre for Public Health

Abstract

This proposal is to develop an expert centre in design and analysis of clinical trials (a Methodology Hub). The Hub will support the design and conduct of clinical trials throughout Ireland, and will provide training to staff who are designing clinical trials. This will result in better quality trials, which are more likely to produce correct results. In turn, this will lead to more efficient use of funds and improved healthcare for patients.

Technical Summary

The overarching aim of this proposal is to develop a Methodology Hub, based in Belfast, which will lead the development of clinical trial methodology on the island of Ireland. The Methodology Hub, when established, will:
1) Develop beacons of excellence in specific areas of trial methodology research.
2) Build training capacity, on an all-island basis, in novel methodologies that span a range of complex intervention types, with an emphasis on translation to improve practice and health outcomes.
3) Improve patient care by strengthening the relevance and validity of the healthcare evidence base, with specific reference to healthcare needs and priorities on the island of Ireland.
4) Establish strong collaborative networks with established Methodology Hubs within the UK and with centres with relevant expertise throughout Ireland.
This proposal seeks to build on existing clinical research infrastructure and investment to facilitate the development of a world-class environment for conducting methodological research. The Hub will aim to improve the design, conduct and analysis of clinical trials and will establish training programmes to develop the next generation of clinical trialists, trial methodologists and clinical trial personnel. A programme of work will be carried out to increase the validity and relevance of early and late phase clinical trials through improved design, conduct and analysis, initially in relation to cancer, vision, public health and nutrition, with a particular emphasis on behavioural modification and complex interventions. The Director and other Hub staff will develop a balanced methodological research portfolio, generated and supported by a broad team of clinical investigators. Mutually beneficial collaborations will be developed with industry where appropriate, and strong linkages with trialists and policy makers throughout Ireland and the UK in order to ensure the dissemination and rapid application of research findings. These linkages will ensure that a research agenda for trial methodology can be maintained which is informed by the needs of the research community.

Publications

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Chalmers I (2016) J Guy Scadding and the move from alternation to randomisation. in Journal of the Royal Society of Medicine

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Antes G (2012) Knowledge as a key resource for health challenges. in Lancet (London, England)

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Layton DM (2016) Lost in translation: Review of identification bias, translation bias and research waste in dentistry. in Dental materials : official publication of the Academy of Dental Materials

 
Description APPG (All Party Parliamentary Group) TB Report on R&D for Global Health
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description Access to clinical data
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
 
Description Advice to WHO and others for Healthy Life Trajectories Initiative (HeLTI), a multi-national randomised trial in Canada, China, India and South Africa
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Cochrane Methodology Reviews
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in systematic reviews
 
Description Cochrane Methodology Reviews - {MC}
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in systematic reviews
Impact The editorial base of the Cochrane Methodology Review Group is in the former All-Ireland Hub for Trials Methodology Research. The Cochrane Methodology Review Group continues to achieve among the highest impact factor of the Cochrane Review Groups
 
Description Cross Government Trial Advice Panel
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
URL https://www.gov.uk/government/publications/cross-government-trial-advice-panel-role-and-membership
 
Description Disaster planning for the UK (Foresight report)
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description Evidence Aid input to International Development Comittee
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description Evidence Aid input to World Humanitarian Summitt
Geographic Reach Multiple continents/international 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
 
Description HRA consultation on the provision of information to trial participants at the end of the study
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description Input from COMET initiative to EMA conssulation on multiplicity in clinical trials
Geographic Reach Europe 
Policy Influence Type Participation in a national consultation
URL https://www.ema.europa.eu/en/multiplicity-issues-clinical-trials
 
Description MECIR for protocols consultation in The Cochrane Collaboration
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a national consultation
 
Description NICE Disinvestment and Eyes on Evidence
Geographic Reach National 
Policy Influence Type Citation in other policy documents
Impact Each month, we highlight 5-10 Cochrane Reviews to NICE that might lead to changes in health and social care in the UK, either through disinvestment in ineffective interventions or increased attention to effective interventions. The disinvestment opportunities are highlighted through the NICE website. A selection of the effective interventions are published in the NICE monthly publication, Eyes on Evidence, which has more than 22,000 subscribers and is also promoted through other routes such as tweets, forwarded emails and articles republished in the Nursing Times.
 
Description PRISMA extensions for Protocols (PRISMA-P) and Individual Participant Data (PRISMA-IPD)
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in systematic reviews
 
Description Particiipation in HSC PHA R&D Division consultation on NI research infrastructure
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description Peer review
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
 
Description Sessions on Systematic Reviews and Meta-analyses for clinical trainees in Northern Ireland
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Trinity College Dublin Library study (midwifery undergraduates)
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Lectures for undergraduate midwives were revised, in relation to information retrieval and critical appraisal.
 
Description Wellcome Trust consultation on access to clinical trial data
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a national consultation
 
Description Department for the Economy PhD Studentship
Amount £50,000 (GBP)
Organisation Department for the Economy, Northern Ireland 
Sector Public
Country United Kingdom
Start 09/2017 
End 09/2020
 
Description Enabling research awards
Amount £35,419 (GBP)
Organisation Public Health Agency (PHA) 
Department HSC Research and Development
Sector Public
Country United Kingdom
Start 07/2014 
End 04/2015
 
Description Evidence Aid
Amount € 500,000 (EUR)
Organisation C and A Foundation 
Sector Private
Country Switzerland
Start 09/2015 
End 09/2018
 
Description Evidence Aid development {MC}
Amount $100,000 (USD)
Organisation Lampert Family Foundation 
Sector Charity/Non Profit
Country United States
Start 12/2014 
 
Description Hubs for Trials Methodology studentship (Process evaluation)
Amount £92,697 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2014 
End 09/2017
 
Description PhD studentship (Core outcome set)
Amount £50,000 (GBP)
Organisation Department for Employment and Learning (DEL) 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2013 
End 07/2016
 
Description PhD studentship (Surrogate outcomes)
Amount £50,000 (GBP)
Organisation Northern Ireland Clinical Trials Unit - NICTU 
Sector Public
Country United Kingdom
Start 03/2015 
End 02/2018
 
Description Telemonitoring Northern Ireland: evaluations
Amount £250,000 (GBP)
Organisation Public Health Agency (PHA) 
Department HSC Research and Development
Sector Public
Country United Kingdom
Start 12/2014 
End 11/2015
 
Title SWAT and SWAR 
Description Studies Within A Trial (SWAT) and Studies Within A review (SWAR) are examples of methodology research that can be embedded in prospective studies and systematic reviews respectively. We have established an online, prospective registry of these, which is freely available to all. The online site allows people to register the outline for SWAT/SWAR and to view the repository. 
Type Of Material Database/Collection of data 
Year Produced 2015 
Provided To Others? Yes  
Impact SWAT and SWAR are being embedded into trials and reviews, improving the evidence base for research methods. 
URL http://go.qub.ac.uk/SWAT-SWAR
 
Description 'Beat the Street Walking to School Competition' 
Organisation Intelligent Health Ltd, UK
Country United Kingdom 
Sector Private 
PI Contribution The research aim is to investigate the characteristics and influence of social networks on children's school travel behaviour. The involvement of Helen McAneney has been in the conceptualising and design of the assessment. RH manages the project and has gained appropriate ethical approval, whilst Helen will carry out the analysis of the network data, once received. Frank Kee will also be involved over analysis and write-up phase. At least 1 peer reviewed publication is envisaged, which the client requests. Helen obtained the data in 2013, has further cleaned the data and carried out initial analysis.
Collaborator Contribution Intelligent Health Ltd have been commissioned to deliver an international schools walking competition called 'Beat the Street'. This is a promotional event format that aims to encourage children to walk to school. It is a multi-week competition format between schools from major cities in each of two or more countries to achieve that goal. The principal promotion is the social interaction of children and reward. Intelligent Health Ltd have recruited schools, installed technology , developed the web-based survey for baseline, 4-week intervention and post-intervention assessments, whereby collecting all the data. Data is to be cleaned and passed to researchers in required format for analysis. In 2012, Beat the Street recruited 12 schools from London, Reading and Vancouver. In 2013 data has been cleaned and passed onto researchers for analysis.
Impact This collaboration has enabled the use of technology to infer network connections, rather than the tradition roster/open question method. It is an extension to the methodology used within the PAL study, in which Helen McAneney is involved, with the potential proof of concept as an intervention amongst School aged children. The collaboration is multi-disciplinary involving those from Public Health, Mathematics/Physics and Network theory.
Start Year 2012
 
Description AIIHPC Structured Research Network 
Organisation All Ireland Institute of Hospice and Palliative Care
Country Ireland 
Sector Charity/Non Profit 
PI Contribution Advice on evaluation research (including core outcomes, randomised trials and systematic reviews).
Collaborator Contribution Conduct of research across hospices and other centres of palliative care on the island of Ireland.
Impact Participation of launch meeting of the Structured Research Network in AIIHPC.
Start Year 2012
 
Description Belgian Red Cross - Flanders and Evidence Aid 
Organisation Belgian Red Cross
Country Belgium 
Sector Charity/Non Profit 
PI Contribution The Director of the All-Ireland Hub worked with the Belgian Red Cross - Flanders to organise the second Evidence Aid Conference in Brussels, in October 2012.
Collaborator Contribution The Belgian Red Cross - Flanders co-hosted the second Evidence Aid Conference, in Brussels in October 2012.
Impact The conference brought together nearly 100 people from a diverse range of organisations. It helped to prioritise future work for Evidence Aid. A report of the 2012 Conference was published as Vandekerckhove P, Clarke MJ, De Buck E, Allen C, Kayabu B. Second Evidence Aid Conference: prioritizing evidence in disaster aid. Disaster Medicine and Public Health Preparedness 2013; 7: 593-596.
Start Year 2011
 
Description COMET 
Organisation Medical Research Council (MRC)
Department Network of Hubs for Trials Methodology Research (HTMR)
Country United Kingdom 
Sector Academic/University 
PI Contribution The All-Ireland Hub worked with the two other Hubs and the Centre for Statistics in Medicine to organise the second COMET (Core Outcome Measures in Effectiveness Trials) conference in Bristol in 2011 and the third in Manchester in 2013. This was made possible through funding from the Network of Hubs. In 2012, the COMET Initiative secured additional funding from the MRC Methodology Research Programme and the European Union FP7 programme.
Collaborator Contribution All partners work in collaboration in this project.
Impact The 2-day second COMET conference was attended by more than 150 researchers and trialists, systematic reviewers, health service users, healthcare practitioners, journal editors, research funders, policy makers and regulators. The interactive meeting included 20 posters on display and short presentations on specific projects. The new COMET website was also available, giving participants an early view of the searchable database available and an opportunity to provide feedback. The meeting promoted much discussion and debate about the methodology, standards and science of outcomes standardisation for effectiveness trials in health care. The strong agreement that this will improve the quality of health research was balanced by the recognition of certain challenges and issues which will need to be tackled head on. Discussion illuminated the need for an international approach to core outcome set development, and this needs to be truly collaborative, with all relevant stakeholder groups involved from the outset. Funders, peer reviewers, journal editors and regulatory authorities have a responsibility to make sure that issues are addressed in research, and the involvement of patients is critical to making sure that appropriate outcomes are measured in effectiveness trials. Since the COMET II Conference, the success of the COMET Initiative has been built upon in securing funding from the MRC Methodology Research Panel and the European Union FP7 programme. These projects will improve the provision of training and support for people working on core outcome sets, and include research into the development and use of core outcome sets. Presentations: UK Critical Care Research Forum, Belfast, Northern Ireland, 12 June 2012 Royal Statistical Society Annual Conference, Telford, England, 5 September 2012 Publications: Williamson PR, Altman DG, Blazeby JM, Clarke M, Devane D, Gargon E, Tugwell P. Developing core outcome sets for clinical trials: issues to consider. Trials 2012; 13: 132.
Start Year 2011
 
Description COMET 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution The All-Ireland Hub worked with the two other Hubs and the Centre for Statistics in Medicine to organise the second COMET (Core Outcome Measures in Effectiveness Trials) conference in Bristol in 2011 and the third in Manchester in 2013. This was made possible through funding from the Network of Hubs. In 2012, the COMET Initiative secured additional funding from the MRC Methodology Research Programme and the European Union FP7 programme.
Collaborator Contribution All partners work in collaboration in this project.
Impact The 2-day second COMET conference was attended by more than 150 researchers and trialists, systematic reviewers, health service users, healthcare practitioners, journal editors, research funders, policy makers and regulators. The interactive meeting included 20 posters on display and short presentations on specific projects. The new COMET website was also available, giving participants an early view of the searchable database available and an opportunity to provide feedback. The meeting promoted much discussion and debate about the methodology, standards and science of outcomes standardisation for effectiveness trials in health care. The strong agreement that this will improve the quality of health research was balanced by the recognition of certain challenges and issues which will need to be tackled head on. Discussion illuminated the need for an international approach to core outcome set development, and this needs to be truly collaborative, with all relevant stakeholder groups involved from the outset. Funders, peer reviewers, journal editors and regulatory authorities have a responsibility to make sure that issues are addressed in research, and the involvement of patients is critical to making sure that appropriate outcomes are measured in effectiveness trials. Since the COMET II Conference, the success of the COMET Initiative has been built upon in securing funding from the MRC Methodology Research Panel and the European Union FP7 programme. These projects will improve the provision of training and support for people working on core outcome sets, and include research into the development and use of core outcome sets. Presentations: UK Critical Care Research Forum, Belfast, Northern Ireland, 12 June 2012 Royal Statistical Society Annual Conference, Telford, England, 5 September 2012 Publications: Williamson PR, Altman DG, Blazeby JM, Clarke M, Devane D, Gargon E, Tugwell P. Developing core outcome sets for clinical trials: issues to consider. Trials 2012; 13: 132.
Start Year 2011
 
Description COMET 
Organisation University of Oxford
Department Centre for Statistics in Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution The All-Ireland Hub worked with the two other Hubs and the Centre for Statistics in Medicine to organise the second COMET (Core Outcome Measures in Effectiveness Trials) conference in Bristol in 2011 and the third in Manchester in 2013. This was made possible through funding from the Network of Hubs. In 2012, the COMET Initiative secured additional funding from the MRC Methodology Research Programme and the European Union FP7 programme.
Collaborator Contribution All partners work in collaboration in this project.
Impact The 2-day second COMET conference was attended by more than 150 researchers and trialists, systematic reviewers, health service users, healthcare practitioners, journal editors, research funders, policy makers and regulators. The interactive meeting included 20 posters on display and short presentations on specific projects. The new COMET website was also available, giving participants an early view of the searchable database available and an opportunity to provide feedback. The meeting promoted much discussion and debate about the methodology, standards and science of outcomes standardisation for effectiveness trials in health care. The strong agreement that this will improve the quality of health research was balanced by the recognition of certain challenges and issues which will need to be tackled head on. Discussion illuminated the need for an international approach to core outcome set development, and this needs to be truly collaborative, with all relevant stakeholder groups involved from the outset. Funders, peer reviewers, journal editors and regulatory authorities have a responsibility to make sure that issues are addressed in research, and the involvement of patients is critical to making sure that appropriate outcomes are measured in effectiveness trials. Since the COMET II Conference, the success of the COMET Initiative has been built upon in securing funding from the MRC Methodology Research Panel and the European Union FP7 programme. These projects will improve the provision of training and support for people working on core outcome sets, and include research into the development and use of core outcome sets. Presentations: UK Critical Care Research Forum, Belfast, Northern Ireland, 12 June 2012 Royal Statistical Society Annual Conference, Telford, England, 5 September 2012 Publications: Williamson PR, Altman DG, Blazeby JM, Clarke M, Devane D, Gargon E, Tugwell P. Developing core outcome sets for clinical trials: issues to consider. Trials 2012; 13: 132.
Start Year 2011
 
Description Centre for Evidence Based Medicine and Evidence Aid 
Organisation University of Oxford
Department Nuffield Department of Primary Care Health Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution The Director of the All-Ireland Hub worked with the Centre for Evidence Based Medicine to organise the first Evidence Aid Conference in Oxford, in September 2011.
Collaborator Contribution The Centre for Evidence Based Medicine co-hosted the first Evidence Aid Conference, in Oxford in September 2011.
Impact The conference brought together more than 70 people from a diverse range of organisations. There were delegates from the Belgian Red Cross, US Center for Disease Control and Prevention, The Cochrane Collaboration, Department for International Development (UK), Health Protection Agency (UK), International Committee for Red Cross, Lancet, Médecins Sans Frontières, OXFAM, Research4Life, Save the Children, UNHCR and the World Health Organization. It helped to identify ways to provide evidence for key issues in practice and in the highlighting of key questions for research relevant to natural disasters and other healthcare emergencies. Future work will include issues relevant to the methods of such research.
Start Year 2011
 
Description Cochrane Methodology Review Group 
Organisation The Cochrane Collaboration
Country Global 
Sector Charity/Non Profit 
PI Contribution The editorial base for the Cochrane Methodology Review Group is in the Northern Ireland Methodology Hub. We oversee the editorial aspects of all Cochrane Methodology Reviews, from the registration of the title through to the publication of the full reviews and its subsequent updates.
Collaborator Contribution Preparation, maintenance and promotion of access to Cochrane Methodology Reviews.
Impact In 2011, the Cochrane Methodology Review Group published new reviews on the assessment of the risk of bias in clinical trials, the impact of checking reference lists to identify clinical trials for systematic reviews and methods for obtaining unpublished data. We also published updated reviews on the impact of randomisation to protect against selection bias in clinical trials and strategies to improve recruitment to randomised trials. In 2012, three new Cochrane Methodology Reviews have been submitted for publication. These cover the likelihood that new interventions will be better than established interventions in randomised trials, the impact of the CONSORT statement, and the effects of industry sponsorship on the reporting of trials. The Impact Factor for the Cochrane Methodology Review Group in 2011 was calculated to be 20.200. This is the highest for any Cochrane Review Group, and contrasts with 5.912 for Cochrane Reviews generally. The Cochrane Methodology Review Group has continued to have the highest impact factor of any CRG.
Start Year 2011
 
Description Connected Health evaluations 
Organisation Government of Northern Ireland
Department Department of Health, Social Services and Public Safety Northern Ireland (DHSSPSNI)
Country United Kingdom 
Sector Public 
PI Contribution The Director of the All Ireland Hub had several meetings with the Permanent Secretary and others in the DHSSPS about the establishment of an evaluative framework for connected health (or integretated healthcare initiatives). This might lead to proposals for a European framework.
Collaborator Contribution Discussions with colleagues in Europe about using the special status of Northern Ireland to lead the establishment of a a European framework for evaluating connected health initiatives. The methodological underpinning of this would have been led by the All-Ireland Hub. It included an evaluation of telecare in Northern Ireland.
Impact Proposal being prepared for colleagues in Europe.
Start Year 2011
 
Description Effective and ineffective interventions in Cochrane Reviews 
Organisation The Cochrane Collaboration
Country Global 
Sector Charity/Non Profit 
PI Contribution The Director of the former All-Ireland Hub works with the Cochrane Editorial Unit to identify health and social care interventions that are effective or ineffective based on the conclusions of Cochrane Reviews.
Collaborator Contribution The Cochrane Collaboration uses this information to improve the impact of Cochrane reviews.
Impact Outputs are shared with Cochrane
Start Year 2018
 
Description Enabling Research Awards panel member 
Organisation Public Health Agency (PHA)
Department HSC Research and Development
Country United Kingdom 
Sector Public 
PI Contribution Mike Clarke was a member of the panel for the Enabling Research Wards in 2014 and 2015.
Collaborator Contribution The HSC PHA R and D Division use the panel to fund awards intended to boost the chances of a more substantial award for researchers in Northern Ireland.
Impact Confidential decisions about funding awards.
Start Year 2014
 
Description Enabling Research Awards panel member (McAuley) 
Organisation Public Health Agency (PHA)
Department HSC Research and Development
Country United Kingdom 
Sector Public 
PI Contribution Danny McAuley has been a member of the panel for the Enabling Research Wards from 2013.
Collaborator Contribution The HSC PHA R&D Division use the panel to fund awards intended to boost the chances of a more substantial award for researchers in Northern Ireland.
Impact Confidential decisions about funding awards.
Start Year 2014
 
Description Evaluation of dNav in Northern Ireland 
Organisation Hygieia
Country United States 
Sector Private 
PI Contribution We have had extensive discussions about an evaluation of this service for diabetics in Northern Ireland. We are awaiting a decision about whether such an evaluation will take place alongside the implementation, which needs to come from HSC Trusts in Northern Ireland.
Collaborator Contribution Hygieia, Inc. provide the service and the equipment. They are committed to an evaluation and have been part of our extensive discussions.
Impact None to date, as this is now awaiting decisions by others; but this is an important example of collaboration between the Hub and industry.
Start Year 2013
 
Description Evidence for Equity 
Organisation University of Ottawa
Department Institute of Population Health
Country Canada 
Sector Academic/University 
PI Contribution The Director of the All Ireland Hub liaises with Evidence for Equity (E4E, formerly Equity Evidence Aid) on behalf of Evidence Aid.
Collaborator Contribution The team in the University of Ottawa lead Equity Evidence Aid.
Impact Strategic meeting of Equity Evidence Aid took place in 2013.
Start Year 2011
 
Description Feedback on HRB review of suicide 
Organisation Irish Health Research Board
Country Ireland 
Sector Charity/Non Profit 
PI Contribution Extensive feedback was provided on a challenging review relevant to suicide prevention in Ireland.
Collaborator Contribution The HRB did the review
Impact Improvements to the report.
Start Year 2014
 
Description GOAL evaluations 
Organisation GOAL Ireland
Country Ireland 
Sector Charity/Non Profit 
PI Contribution Advice on evaluation studies and assistance in appointment of new member of the GOAL evaluation team.
Collaborator Contribution Conduct of their evaluations and appointment of their new staff member.
Impact Evaluations ongoing and staff member details are probably protected under data protection.
Start Year 2014
 
Description Health Research Board, Ireland 
Organisation Health Research Board (HRB)
Country Ireland 
Sector Public 
PI Contribution The Director of the All-Ireland Hub has held several discussions with senior staff at the Health Research Board (HRB) in regard to expanding the work of the Hub to the island of Ireland as a whole; and as part of the assesment of the Cochrane Training Fellowship Scheme. In 2012, the HRB agreed to contribute to the costs for expanding the Hub into Ireland.
Collaborator Contribution Cooperation in strengthening research in Ireland.
Impact In 2011, a report on the Cochrane Training Fellowship Scheme was prepared for consideration by the Board of the HRB, recommending the continuation of the scheme. An outline proposal is being prepared for the Board of the HRB on the strengthening of methodology research and support in the Republic of Ireland, including the potential role of the All-Ireland Hub and the Network of Hubs in this. In 2012, the HRB agreed to contribute 1 million euros to the MRC to fund the expansion of the All-Ireland Hub to Ireland and a further 250,000 euros to the work of the Network of Hubs.
Start Year 2011
 
Description Humanitarian Evidence Programme 
Organisation Oxfam GB
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution We provided guidance on the methods to use in the systematic reviews commissioned by the Humanitarian Evidence Programme, and on applications and protocols for these reviews.
Collaborator Contribution Oxfam and Tufts oversee the Humanitarian Evidence Programme
Impact Successful awards for systematic reviews.
Start Year 2015
 
Description Humanitarian Evidence Programme 
Organisation Tufts University
Country United States 
Sector Academic/University 
PI Contribution We provided guidance on the methods to use in the systematic reviews commissioned by the Humanitarian Evidence Programme, and on applications and protocols for these reviews.
Collaborator Contribution Oxfam and Tufts oversee the Humanitarian Evidence Programme
Impact Successful awards for systematic reviews.
Start Year 2015
 
Description LSHTM Annual Lecture 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Annual lecture on the importance of randomised trials and systematic reviews.
Collaborator Contribution Course on evidence based global health.
Impact Annual lecture, and discussions about joint projects relating to large randomised trials and Evidence Aid.
 
Description Molecular Medicine Ireland 
Organisation Molecular Medicine Ireland
Country Ireland 
Sector Academic/University 
PI Contribution The Director of the All-Ireland Hub has had several discussions with the Chief Executive Office of Molecular Medicine Ireland about collaborative efforts across the island of Ireland, through 2011 and 2012. The Director sits on the Board of the MMI as an observor for QUB.
Collaborator Contribution Cooperation to strengthen research on the island of Ireland.
Impact The Director of the Hub continues as a representative of Queen's University Belfast on the MMI Board.
Start Year 2011
 
Description NICE and disinvestment 
Organisation National Institute for Health and Care Excellence (NICE)
Country United Kingdom 
Sector Public 
PI Contribution The Director of the All-Ireland Hub has continued to work with the UK Cochrane Centre, the Cochrane Editorial Unit and NICE to identify opportunities for disinvestment from ineffective health care through the findings of new and updated Cochrane Reviews. In 2012, the work was sub-contracted from the UK Cochrane Centre to Queen's University Belfast. A extension and a new contract means that this work will continue to at least 2016.
Collaborator Contribution NICE use the output from this project to identify low value interventions to the NHS.
Impact NICE has continued to publish "Cochrane QP" in NHS Evidence, highlighting ineffective healthcare interventions to practioners and commissioners in the NHS.
Start Year 2011
 
Description Network of Hubs for Trials Methodology Research 
Organisation Medical Research Council (MRC)
Department Network of Hubs for Trials Methodology Research (HTMR)
Country United Kingdom 
Sector Academic/University 
PI Contribution The All-Ireland Hub has worked within the Network of Hubs on a variety of projects, including outcomes (see COMET), evidence synthesis and trial recruitment. The Director of the All-Ireland Hub has been Chair of the Network since September 2011, and led the successful application for the renewal of funding for the Network (£1 million) and the establishment of a PhD studentship fund (£2.3 million).
Collaborator Contribution The other Hubs in the Network of Hubs have helped to establish the All-Ireland Hub's plans for research. They are already collaborating in projects relating to outcomes, evidence synthesis and recruitment to trials.
Impact The second and third COMET conferences, the evidence synthesis session for the Network's Conference in February 2012, and a short document setting out issues to consider if one is struggling with the recruitment to a trial.
Start Year 2011
 
Description Northern Ireland CTU 
Organisation Northern Ireland Clinical Trials Unit - NICTU
Country United Kingdom 
Sector Public 
PI Contribution Director NICTU
Collaborator Contribution The NICTU is a UK Clinical Research Collaboration (UKCRC) registered Clinical Trials Unit and has a specific remit to provide support for the design, conduct, analysis and publication of clinical trials and other well designed studies.
Impact Portfolio of NIHR grant applications and successful applications
Start Year 2013
 
Description Northern Ireland Clinical Trials Unit signposting and back-up advice 
Organisation Northern Ireland Clinical Trials Unit - NICTU
Country United Kingdom 
Sector Public 
PI Contribution When researchers approach the NICTU for advice that is for a study outside their scope, they suggest that the researcher contact the HSC Statistical and Methodological Support Service. The service then provides the relevant advice and support, as appropriate.
Collaborator Contribution The NICTU advises researchers who approach them with studies that are outside their scope to contact the Support Service.
Impact Several discussions have taken place and advice has been given, but there no formal outputs to date.
Start Year 2017
 
Description OptiBIRTH 
Organisation Trinity College Dublin
Country Ireland 
Sector Academic/University 
PI Contribution Design, conduct and analysis of cluster randomised trial
Collaborator Contribution Oversight of this EU FP7 research project, including identifcation of the intervention to test in the trial.
Impact No impacts yet.
Start Year 2012
 
Description Prioritisation of reviews for disasters 
Organisation Government of the UK
Department Department for International Development (DfID)
Country United Kingdom 
Sector Public 
PI Contribution Evidence Aid led a prioritisation exercise for reviews needed in disaster risk reduction, planning, response and recovery. This unique activity involved dozens of agencies and hundreds of individuals in online surveys, and a 2-day workshop with 30 participants.
Collaborator Contribution Dozens of agencies and hundreds of agencies contributed to the online surveys. 30 people took part in the 2-day workshop.
Impact Evidence Aid Priority Setting Group EAPSG. Prioritization of Themes and Research Questions for Health Outcomes in Natural Disasters, Humanitarian Crises or Other Major Healthcare Emergencies. PLOS Currents Disasters. 2013 Oct 16. Edition 1. doi: 10.1371/currents.dis.c9c4f4db9887633409182d2864b20c31.
Start Year 2013
 
Description Prioritisation of reviews for disasters 
Organisation Médecins Sans Frontières (MSF)
Country France 
Sector Charity/Non Profit 
PI Contribution Evidence Aid led a prioritisation exercise for reviews needed in disaster risk reduction, planning, response and recovery. This unique activity involved dozens of agencies and hundreds of individuals in online surveys, and a 2-day workshop with 30 participants.
Collaborator Contribution Dozens of agencies and hundreds of agencies contributed to the online surveys. 30 people took part in the 2-day workshop.
Impact Evidence Aid Priority Setting Group EAPSG. Prioritization of Themes and Research Questions for Health Outcomes in Natural Disasters, Humanitarian Crises or Other Major Healthcare Emergencies. PLOS Currents Disasters. 2013 Oct 16. Edition 1. doi: 10.1371/currents.dis.c9c4f4db9887633409182d2864b20c31.
Start Year 2013
 
Description Prioritisation of reviews for disasters 
Organisation World Health Organization (WHO)
Country Global 
Sector Public 
PI Contribution Evidence Aid led a prioritisation exercise for reviews needed in disaster risk reduction, planning, response and recovery. This unique activity involved dozens of agencies and hundreds of individuals in online surveys, and a 2-day workshop with 30 participants.
Collaborator Contribution Dozens of agencies and hundreds of agencies contributed to the online surveys. 30 people took part in the 2-day workshop.
Impact Evidence Aid Priority Setting Group EAPSG. Prioritization of Themes and Research Questions for Health Outcomes in Natural Disasters, Humanitarian Crises or Other Major Healthcare Emergencies. PLOS Currents Disasters. 2013 Oct 16. Edition 1. doi: 10.1371/currents.dis.c9c4f4db9887633409182d2864b20c31.
Start Year 2013
 
Description Public Health England and Evidence Aid 
Organisation Public Health England
Department Centre for Radiation, Chemicals and Environmental Hazards (CRCE)
Country United Kingdom 
Sector Public 
PI Contribution The Director of the All-Ireland Hub has worked with Professor Virginia Murray and her colleagues at Public Health England (formerly, the Public Health Agency) on various projects relevant to the provision of evidence for natural disasters and other healthcare emergencies, including topics relevant to improving the methods for the relevant research. These include a rapid Cochrane Review of the effects of electric fans in heatwaves.
Collaborator Contribution Collaboration on the design and preparation of the Cochrane Review of electric fans in heatwaves and other discussions relevant to Evidence Aid. Development of resources for Evidence Aid in response to Typhoon Haiyan in the Phlippines (November 2013)
Impact Kar-Purkayastha I, Clarke M, Murray V. Dealing with disaster databases - what can we learn from health and systematic reviews? Application in practice. PLoS Currents Disasters 2011;3:RRN1272. Gupta S, Carmichael C, Simpson C, Clarke MJ, Allen C, Gao Y, Chan EYY, Murray V. Electric fans for reducing adverse health impacts in heatwaves. Cochrane Database of Systematic Reviews 2012, Issue 7. Art. No.: CD009888. Resources on www.EvidenceAid.org
Start Year 2011
 
Description R&D Division, HSC Public Health Agency, Northern Ireland 
Organisation Public Health Agency (PHA)
Department HSC Research and Development
Country United Kingdom 
Sector Public 
PI Contribution The Director of the All-Ireland Hub provided methodological advice and input to the review of applications for funds for rapid systematic reviews in various areas of mental health. in 2012, the Hub provided advice to the R&D Division on the recent opening up of NIHR funding streams to researchers from Northern Ireland. In October 2012, the R&D Division agreed to continue to contribute £50,000 per year to the Hub should its renewal bid be successful. In 2017, the Northern Ireland Methodology Hub took on the role of providing advice to researchers in the Health and Social Care sector in Northern Ireland who need support with statistics or methodology
Collaborator Contribution Cooperation on strengthening research in Northern Ireland.
Impact The R&D Division awarded a series of grants for rapid systematic reviews following the assessment process in 2011. The R&D Division agreed to continue to contribute £50,000 per year to the Hub should its renewal bid be successful. The R&D Division provides £30,000 per year to the Northern Ireland Methodology Hub for the HSC Statistical and Methodological Support service.
Start Year 2011
 
Description Studies Within A Trial (SWAT) and Studies Within A Review (SWAR) - {MC} 
Organisation Medical Research Council (MRC)
Department Network of Hubs for Trials Methodology Research (HTMR)
Country United Kingdom 
Sector Academic/University 
PI Contribution The All-Ireland Hub for Trials Methodology Research led the SWAT and SWAR programmes and developed an online repository of these outlines for studies that will facilitate methodology research in clinical trials, systematic reviews and other research. Following the end of the MRC award to develop this Hub, the Northern Ireland Methodology Hub continues to maintain the repository, including adding new outlines.
Collaborator Contribution The Network of Hubs for Trials Methodology Research provided funding for the establishment of this project. The other partners include other Hubs, the NIHR HTA programme, and the HRB Trials Methodology Research Network, Clinical Trials Units and others will contribute ideas and support the dissemination and implementation of SWAT and SWAR.
Impact Website has been established and SWAT and SWAR are being conducted.
Start Year 2014
 
Description Studies Within A Trial (SWAT) and Studies Within A Review (SWAR) - {MC} 
Organisation National Institute for Health Research
Country United Kingdom 
Sector Public 
PI Contribution The All-Ireland Hub for Trials Methodology Research led the SWAT and SWAR programmes and developed an online repository of these outlines for studies that will facilitate methodology research in clinical trials, systematic reviews and other research. Following the end of the MRC award to develop this Hub, the Northern Ireland Methodology Hub continues to maintain the repository, including adding new outlines.
Collaborator Contribution The Network of Hubs for Trials Methodology Research provided funding for the establishment of this project. The other partners include other Hubs, the NIHR HTA programme, and the HRB Trials Methodology Research Network, Clinical Trials Units and others will contribute ideas and support the dissemination and implementation of SWAT and SWAR.
Impact Website has been established and SWAT and SWAR are being conducted.
Start Year 2014
 
Description Studies Within A Trial (SWAT) and Studies Within A Review (SWAR) - {MC} 
Organisation National University of Ireland, Galway
Country Ireland 
Sector Academic/University 
PI Contribution The All-Ireland Hub for Trials Methodology Research led the SWAT and SWAR programmes and developed an online repository of these outlines for studies that will facilitate methodology research in clinical trials, systematic reviews and other research. Following the end of the MRC award to develop this Hub, the Northern Ireland Methodology Hub continues to maintain the repository, including adding new outlines.
Collaborator Contribution The Network of Hubs for Trials Methodology Research provided funding for the establishment of this project. The other partners include other Hubs, the NIHR HTA programme, and the HRB Trials Methodology Research Network, Clinical Trials Units and others will contribute ideas and support the dissemination and implementation of SWAT and SWAR.
Impact Website has been established and SWAT and SWAR are being conducted.
Start Year 2014
 
Description Studies Within A Trial (SWAT) and Studies Within A Review (SWAR) - {MC} 
Organisation University of Oxford
Department Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU)
Country United Kingdom 
Sector Academic/University 
PI Contribution The All-Ireland Hub for Trials Methodology Research led the SWAT and SWAR programmes and developed an online repository of these outlines for studies that will facilitate methodology research in clinical trials, systematic reviews and other research. Following the end of the MRC award to develop this Hub, the Northern Ireland Methodology Hub continues to maintain the repository, including adding new outlines.
Collaborator Contribution The Network of Hubs for Trials Methodology Research provided funding for the establishment of this project. The other partners include other Hubs, the NIHR HTA programme, and the HRB Trials Methodology Research Network, Clinical Trials Units and others will contribute ideas and support the dissemination and implementation of SWAT and SWAR.
Impact Website has been established and SWAT and SWAR are being conducted.
Start Year 2014
 
Description Studies Within A Trial (SWAT) and Studies Within A Review (SWAR) - {MC} 
Organisation University of Oxford
Department National Perinatal Epidemiology Unit Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution The All-Ireland Hub for Trials Methodology Research led the SWAT and SWAR programmes and developed an online repository of these outlines for studies that will facilitate methodology research in clinical trials, systematic reviews and other research. Following the end of the MRC award to develop this Hub, the Northern Ireland Methodology Hub continues to maintain the repository, including adding new outlines.
Collaborator Contribution The Network of Hubs for Trials Methodology Research provided funding for the establishment of this project. The other partners include other Hubs, the NIHR HTA programme, and the HRB Trials Methodology Research Network, Clinical Trials Units and others will contribute ideas and support the dissemination and implementation of SWAT and SWAR.
Impact Website has been established and SWAT and SWAR are being conducted.
Start Year 2014
 
Description Tom Valente 
Organisation University of Southern California
Country United States 
Sector Academic/University 
PI Contribution Team has collected and analysed data.
Collaborator Contribution Intellectual input into research.
Impact Poster presentation at XXXIII Sunbelt Social Networks Conference of the International Network for Social Network Analysis (INSNA), May 21-26 2013, Hamburg, Germany. Accepted publication in American Journal of Public Health, "Hidden" social networks in behavior change interventions.
Start Year 2013
 
Description Trial Forge - {MC} 
Organisation Medical Research Council (MRC)
Department Network of Hubs for Trials Methodology Research (HTMR)
Country United Kingdom 
Sector Academic/University 
PI Contribution The All-Ireland Hub for Trials Methodology Research helped to coordinate this workshop.
Collaborator Contribution Other partners contributed to the workshop financially and scientifically.
Impact None to date
Start Year 2014
 
Description 1st Dilemma Seminar 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact This lunchtime seminar presented a real-life trial dilemma faced by researchers in QUB and discussed possible solutions and the repercussions of each choice. The context of the dilemma was be that of a multi-centre Glaucoma Trial which would compare a new method of imaging over current practice. The dilemma faced by researchers regards the different types of imaging that is used in different study sites. A presentation was given by Professsor Augusto Azuara-Blanco who was conducting the Trial and the group discussed the possible actions that could be taken. Afterwards, Professor Azuara-Blanco revealed the decision he made and explained the reasoning behind this.

After the seminar, those in attendance said that the seminar was very interesting and would make the think differently when they face their own research dilemmas.
Year(s) Of Engagement Activity 2013
 
Description AUKCAR methodology workshop, invited presentation Helen McAneney 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Invited presentation at AUKCAR workshop on the SWAT (Studies Within A Trial) and SWAR (Studies Within A Review) Programme.
Year(s) Of Engagement Activity 2017
 
Description Attending MRC methodological hub and contributing to olanning and activities 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Participants in your research and patient groups
Results and Impact The decision le dto a lot of work and successful PhD proposals


Ensured that staff from Ulster University participate diin the Hub and wrote research proposals
Year(s) Of Engagement Activity 2011,2012,2013,2014
 
Description BCT Taxonomy Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact 56 individuals attended a one day workshop on the Behaviour Change Taxonomy. This involved lectures, practical sessions and discussion of the application of the taxonomy in designing and evaluating interventions and policies. Attendees included academics, public health practitioners and members of community health organisations.

Interest to pursue the same methodological concept in other settings.
Year(s) Of Engagement Activity 2014
 
Description BERA presentation by Gareth Robinson 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Presentation at BERA on "A Social Network Perspective of Shared Education in Northern Ireland"
Year(s) Of Engagement Activity 2016
 
Description British Council Campus Tours 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact British Council Campus Tour to promote research within the faculty and own work.
Year(s) Of Engagement Activity 2016
 
Description COMET lecture (UK Critical Care Research Forum) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Health professionals
Results and Impact Lecture on core outcome sets (COMET).

Plans to develop two core outcome sets in this area.
Year(s) Of Engagement Activity 2012
 
Description Clinical Trials the All-Ireland Hub 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Health professionals
Results and Impact This presentation and question session was given as part of the Doctoral Midwifery Research Society's annual meeting.

The All-Ireland Hub was promoted to the audience of Midwifery students in the University of Ulster and Queen's University Belfast.
Year(s) Of Engagement Activity 2013
 
Description Cochrane Evidence Pods and Journal Clubs 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The Director of the All-Ireland Hub is Podcast and Journal Club editor for The Cochrane Library. He oversees the preparation and publication of all Evidence Pods and the monthly Journal Clubs. These are available from www.cochrane.org/podcasts and www.CochraneJournalClub.com. Both collections are freely available on the internet.

The Evidence Pods and Journal Clubs cover a wide range of areas of health care, and highlight methodological issues as appropriate. The podcasts are listened to thousands of time per month and the Journal Clubs atrract several thousand visitors a month, and has more than 8000 followers in November 2013.
Year(s) Of Engagement Activity 2011,2012,2013
URL http://www.cochrane.org/podcasts; www.CochraneJournalClub.com
 
Description Cochrane Evidence Pods and Journal Clubs - {MC} 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The Director of the All-Ireland Hub (Mike Clarke) is Podcast and Journal Club editor for The Cochrane Library. He oversees the preparation and publication of all Evidence Pods and the Journal Clubs. These are available from www.cochrane.org/podcasts and www.CochraneJournalClub.com. Both collections are freely available on the internet.

The Evidence Pods and Journal Clubs cover a wide range of areas of health care, and highlight methodological issues as appropriate. The podcasts are listened to thousands of time per month and the Journal Clubs attract several thousand visitors a month.
Year(s) Of Engagement Activity 2009,2010,2011,2012,2013
URL http://www.cochrane.org/podcasts
 
Description Complex Systems, Health Disparities & Population Health: Building Bridges - Poster 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Smartphones - a method for longitudinal survey data capture: One step forward or two steps back?
Helen McAneney, Mark McCann, John Moriarty, Mark Tully, Leeanne O'Hara, Oliver Perra, Suleiman Yerima, Sakir Sezer, Paul Ell, Robert Miller, Geraldine Macdonald.
Interaction and discussion on concept.

Continued interaction with international colleague with potential for future collaboration.
Year(s) Of Engagement Activity 2014
URL http://conferences.thehillgroup.com/UMich/complexity-disparities-populationhealth/
 
Description Debating Matters (judge in October 2014) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Mike Clarke was a panel member for this event, sponsored by MRC and Wellcome Trust. His involvement led to extensive discussion with the school students who took part in the debating competition and with the organisers, including the Queen's University Belfast Literific Society about greater engagement in health and social care research, through debates around uncertainties.

Invitation to suggest topics for debate to Literifics Society, request for quote for media release for Debating Matters and invitation to judge again in 2015.
Year(s) Of Engagement Activity 2014
URL http://www.debatingmatters.com/
 
Description Development Weeks - QUB 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Presentation to undergraduate biomedical science students on my research area of Research Methodology and work in Centre for Public Health, which sparked interaction and good feedback.
Year(s) Of Engagement Activity 2017,2018
 
Description Development of Evidence Based Aid: Helping Decision Makers Before and After Natural Disasters 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact This meeting was open to the public as part of the Development Research Week Programme at Trinity College Dublin, Ireland; and was organized in partnership with the Trinity International Development Initiative. The meeting was chaired by the Director of the All-Ireland Hub, one of the founders of Evidence Aid. It offered an opportunity for organisations based in Ireland to consider the role that Evidence Aid can play to promote evidence-based practices in humanitarian emergencies and international development. The plenary session included talks on the use of evidence by donors in the humanitarian sector and related areas (Ciara O'Brien, Deputy Director, Emergency and Recovery Section, Irish Aid), an NGO's perspective on how evidence was, or was not, used in the Horn of Africa (Austin Kennan, Regional Director, Horn of Africa, Concern), and the inclusion of evidence based practice in the academic curriculum (Pat Gibbons, Director, MSc Humanitarian Action, UCD). Bonnix Kayabu, Evidence Aid Co-ordinator, also spoke about the role of systematic reviews and the Evidence Aid needs assessment survey. After these talks, small group discussions allowed participants to focus on these issues in more detail.

Participants in the meeting agreed to follow-up on the discussions, to help strengthen the use of research evidence by development agencies on the island of Ireland.
Year(s) Of Engagement Activity 2011
 
Description ESO Masterclass on Systematic Reviews 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This 5-day workshop has led to requests to Mike Clarke (who organised, provided academic leadership and taught on the workshop) run similar courses for cancer guidelines, to contribute to systematic reviews and to edit the ESMO Handbook of Interpreting Clinical Study Results.

Improved understanding of the role of systematic reviews in cancer care, guidelines and policy across Europe. The Masterclass is likely to be run again in 2016, because of its success.
Year(s) Of Engagement Activity 2014
URL http://www.eso.net/events-2.html?e=ESO_Masterclass_on_Systematic_Reviews_in_Cancer_Care,_Guidelines_...
 
Description ESRC Festival Event - {LM} 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Schools
Results and Impact Twenty people (a mixture of school teachers, principals and researchers) attended an event targeted at teaching professionals, in both primary and secondary level education, to understand their experience of social science research and understand and tackle participation barriers and survey fatigue in schools. The first half of the event showcased current school-based social research in both Queen's University and the University of Ulster. The second half of the event focused on eliciting the views of schools who have participated in research.

Delegates were asked to complete a detailed feedback from for the event provided by the ESRC. Specific comments we received were:
- I was very impressed and satisfied with the event as a whole
- Excellent
- Very useful event which will benefit my future research in schools.
- Thank you - this was an enlightening experience and as a teacher it is beneficial to conducting research. Thank you for hearing my voice.

Dr Maguire was approached after the event to discuss with a researcher a research project that they were planning.
Year(s) Of Engagement Activity 2014
URL http://www.qub.ac.uk/directorates/ResearchEnterprise/ResearchDevelopment/TrainingandEvents/UpcomingE...
 
Description Economics workshop in University of Ulster Summer School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Academics, healthcare practitioners and civil servants attended this workshop on health economics.

Led to work on proposals for NIHR funding and an invitation to lecture to phamacy students in the University of Ulster.
Year(s) Of Engagement Activity 2012,2013
 
Description Evidence Aid 2-day workshop on systematic reviews for humanitarian emergencies 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This 2-day workshop (13-14 November 2014), taught entirely by Mike Clarke (on behalf of Evidence Aid), sparked considerable interest and generated learning in the 10 participants from UN agencies, funding organisations, academic research teams, and NGOs about the conduct and use of systematic reviews in the humanitarian sectors.

Impacts will accrue over the coming months and years but have already included invitations to advise on substantial evidence generation and knowledge transfer activities relevant to the WHO, DFID (Department for International Development, UK), Tufts University and OXFAM.
Year(s) Of Engagement Activity 2014
URL http://www.evidenceaid.org/events-and-training/internal-training-events/
 
Description Evidence Aid letter in Belfast Telegraph 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Letter stimulated thinking about use of evidence in disasters

None known.
Year(s) Of Engagement Activity 2013
URL http://www.belfasttelegraph.co.uk/opinion/letters/aid-should-be-evidencebased-even-in-a-crisis-29772...
 
Description Evidence Aid letter in The Independent 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Stimulated thinking about the need for evidence in disasters in a major national newspaper, with interventional reach.

None known
Year(s) Of Engagement Activity 2013
URL http://www.independent.co.uk/voices/letters/letters-where-is-the-wests-cyclone-aid-for-somalia-89476...
 
Description Evidence Aid: 2 day workshop on systematic reviews 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Health professionals
Results and Impact 15 people took part in the 2-day workshop which was facilitated by the Director of the All Ireland Hub. They cam from a variety of disaster and aid agencies.

Some of the participants worked together to published the first Cochrane Review for Evidence Aid: Gupta S, Carmichael C, Simpson C, Clarke MJ, Allen C, Gao Y, Chan EYY, Murray V. Electric fans for reducing adverse health impacts in heatwaves. Cochrane Database of Systematic Reviews 2012, Issue 7. Art. No.: CD009888.
Year(s) Of Engagement Activity 2012
 
Description Facilitation of NICHS strategic review 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Third sector organisations
Results and Impact Mike Clarke facilitated a workshop to allow the charity, Northern Ireland Chest Heart and Stroke, start the planning process for a new research and funding strategy. It will lead to the new strategy, which includes the allocation of more than £500,000 funding to Northern Ireland researchers each year.
Year(s) Of Engagement Activity 2018
 
Description Faculty Outreach and STEM event 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Showcase and taster of research of the centre and own area to school children. The success of the event led to being asked to perform the workshop again at the Faculty showcase to the British Council campus visit.
Year(s) Of Engagement Activity 2016
 
Description From bench-side to curb-side: maximizing obesity research to impact health - {LM} 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Grace O'Malley presented the results of her PhD research (Professor Mike Clarke supervised) to an audience of 25. Sixteen of those were from Queen's University Belfast and the University of Ulster, seven came from the public section and two were in attendance from the third sector. breakdown. The audience had the opportunity to discuss the issues arising from the presentation and also had the opportunity to ask Grace questions.

This seminar increased the awareness of the ethical consideration in conducting health-based research with young people.
Year(s) Of Engagement Activity 2014
 
Description Good randomised trials lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Lecture on "What makes a good randomised trial" at Nottingham Clinical Trials Unit (CTU) to an audience of 40+ researchers and practitioners.

Collaboration with Nottingham CTU on randomised trials and methodology research.
Year(s) Of Engagement Activity 2012
 
Description HRB TMRN 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Member and expert (in networks) listed within the HRB Trials Methodology Research Network.
Year(s) Of Engagement Activity 2015,2016,2017
URL https://www.hrb-tmrn.ie/
 
Description HRB TMRN Webinar July 2016 Helen McAneney 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited to give a webinar for the HRB Trials Methodology Research Network. Talk entitled "Networks within Trials: Blessing or burden?". The talk sparked questions and discussion afterwards.
Year(s) Of Engagement Activity 2016
URL https://www.hrb-tmrn.ie/online-material-info/webinar-dr-helen-mcaneney-networks-within-trials-blessi...
 
Description How much do you need: can readers get the key messages from summaries of Cochrane reviews without reading the full review - {LM} 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Lisa Maguire and Mike Clarke presented the results of their study into Cochrane summaries. The seminar consisted of a 45 minute presentation with a 15 minute question and discussion session. Twenty-five people attended. One person attended from the third-sector the rest were from Queen's University and the University of Ulster.

The seminar's main impact was information dissemination. A colleague approached me after the presentation and asked for my slides and said that 'I think that your study would be of interest to members of the public health research network and was wondering if it would be possible to add a link to your presentation in our next ezine and on the website'.
Year(s) Of Engagement Activity 2014
 
Description Hub Roadshow, Altnagelvin Hospital - {MC} 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact This was the first Roadshow for the Hub for Trials Methodology Research. It was a 1-day event at the Clinical Translational Research and Innovation Centre (C-TRIC), Altnagelvin Hospital Campus, Derry/Londonderry on 4 February 2014.

Advice was given which will have changed the conduct of some trials and it stimulated greater interest in the Hub.
Year(s) Of Engagement Activity 2014
 
Description Hub Roadshow, Belfast Health and Social Care Trust - {MC} 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact This was the second Roadshow for the Hub for Trials Methodology Research. It took place at the Royal Hospital in Belfast on 2 September 2014. It was a joint event with the Northern Ireland Clinical Trial Unit.

Advice was given which will have changed the conduct of some trials and it stimulated greater interest in the Hub.
Year(s) Of Engagement Activity 2014
 
Description Hub for Trials Methodology Research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Lecture to the annual All Ireland Cochrane Contributors' meeting, January 2013

Greater knowledge of the Hub and possible collaborations.
Year(s) Of Engagement Activity 2013
 
Description Hub for Trials Methodology Research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Lecture about the Hub to the Physical Activity Research Group in Queen's University Belfast.

Greater knowledge about the Hub and opportunities for collaboration.
Year(s) Of Engagement Activity 2013
 
Description Hub for Trials Methodology Research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Health professionals
Results and Impact Lecture to Doctoral Midwifery Research Society Meeting at Queen's University Belfast.

Greater knowledge of the Hub and possible collaborations.
Year(s) Of Engagement Activity 2013
 
Description LSHTM lecture on systematic reviews and The Cochrane Collaboration 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Informed students on the LSHTM Masters in Global Health about systematic reviews, The Cochrane Collaboration and Evidence Aid

Several participants asked questions after the lectures, and some followed up with subsequent involvement in Evidence Aid
Year(s) Of Engagement Activity Pre-2006,2006,2007,2008,
 
Description Latent class analysis workshop in University of Ulster Summer School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Academics, healthcare practitioners and civil servants attended this workshop on the statistics of latent class analysis.

Led to invitation to lecture on statistics in England.
Year(s) Of Engagement Activity 2012
 
Description MRC/NIHR Research Symposium 2014 - Steering committee and participant 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Interaction and discussion with other methodologists on day.
Steering committee- involvement in decisions on speakers, style of day and organisation.

Two PhD Students have requested further knowledge from the days events. I have asked/invited one of the speakers at the event to give a seminar within the University.
Year(s) Of Engagement Activity 2014
URL http://www.nihr.ac.uk/funding/nihr-and-mrc-symposium-for-early-career-research-methodologists.htm
 
Description NIMDTA Evidence Based Medicine Workshop 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Two lectures by Mike Clarke (Understanding systematic reviews and Risk and odds ratios and meta-analyses" generated much discussion during and after the session. The sessions were part of a 1-day workshop for clinician trainees in Northern Ireland.

The sessions by Mike Clarke were rated most highly by the participants (means of 9.3 out of 10), compared to a mean of 8.3 for the other 9 sessions (next highest was 8.8); and have led to subsequent meetings about research involvement. Mike is likely to be invited to do the sessions again at a repeat event in 2015.
Year(s) Of Engagement Activity 2014
URL http://www.nimdta.gov.uk/evidence-based-medicine-workshop/
 
Description North Dublin Voluntary Forum Research Conference 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Panel discussion on "The challenges facing Lifespan Diabetes Research in Ireland and what we can do to overcome them" as part of LIFESPAN DIABETES RESEARCH: PROGRAMME. November 14 2013, by Vivien Coates.


Opportunity to inform researchers in diabetes about the work of the Hub for Trials Methodology Research
Year(s) Of Engagement Activity 2013
 
Description Presentation at York Food and Drink Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Around 40 individuals attended the talk which drew upon the alcohol research of the Principle Investigator including the findings from randomised trials and trial dsign. This was an interactive presentation with multiple questions and discussions following with members of the public.

I have been asked to submit a summary about the talk in the North East BPS Bulletin
The talk was quoted in several tweets (not including by the organisers) during and after the event.
Several individuals expressed a) an increase in their understanding of the psychological processes around substance use (including alcohol, smoking and drug use); b) that they would use the behaviour change principles employed in the intervention being evaluated in the grant to reduce their smoking (through gradual change; diary keeping and motivational principles); c) a better understanding of evidence based intervention and trials
Year(s) Of Engagement Activity 2014
URL http://www.yorkfoodfestival.com/festival.php?day=5
 
Description Queen's Professor (Mike Clarke) named one of top 400 global researchers 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Generated interest in the story, and contacts from colleagues

Colleagues contacted Mike Clarke to discuss research collaborations.
Year(s) Of Engagement Activity 2013
URL http://www.qub.ac.uk/home/ceao/News/ArchivedPressReleases/2013PressReleases/December2013pressrelease...
 
Description RSS lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Lecture on core outcome sets (COMET).

Increased interest in involvement in the development of core outcome sets.
Year(s) Of Engagement Activity 2012
 
Description Random walk lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Lecture on randomised trials.

Increased interest in randomised trials and discussion of invitation to repeat the lecture elsewhere.
Year(s) Of Engagement Activity 2012
 
Description Randomised Trial Course - {MC} 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Approximately 25 researchers attended this 2-day workshop to learn about randomised trials, on 7-8 May 2014 at Riddell Hall Belfast and approximately 30 researchers attended the second running of the workshop in September 2015 at Riddell Hall Belfast.

Some attendees have approached the All-Ireland Hub for Trials Methodology Research for further advice on the conduct of trials and the funding applications.
Year(s) Of Engagement Activity 2014,2015
 
Description Rare Disease Education and Registry - Host of event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Discussion on how recent developments have led to unique opportunities for individuals living and working with rare diseases in Northern Ireland. This includes the two priorities from the NI rare disease implementation plan include:

(1) Developing a rare disease registry, and

(2) Improving education / access to information resources in NI

To help progress these rare disease priorities, a series of short talks will be followed by facilitated discussions to identify targets for rare disease progress in NI, alongside barriers and strengths for implementation.
Year(s) Of Engagement Activity 2018
 
Description Recruitment strategies lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Lecture to staff of the Northern Ireland Clinical Trials Unit

Greater knowledge in the staff team.
Year(s) Of Engagement Activity 2013
 
Description Review of funding applications for German Federal Ministry of Education and Research (BMBF) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Prof Clarke provided expert review of four applications for funding for systematic reviews for the German Federal Ministry of Education and Research.
Year(s) Of Engagement Activity 2018
 
Description STEM Ambassador 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Schools
Results and Impact Speed Networking W5 2012 - Over 800 Year10 pupils from 8 schools attended the two day STEM Careers Event. By rotation, interacted with small groups (6-8 pupils) for 5 minute intervals, sparking of discussion on my research as well as STEM subjects.

Career Fair Feb 2016 - Over 500 pupils from schools within Bangor attended the afternoon Careers Event. A colleague and I manned a table and interacted with pupils and parents interested in Public Health. The conversations sparked interest in Public Health, the research undertaken and how to get involved.

Invited by University Staff Training and Development Unit to speak to research staff on my experiences as a STEM Ambassador in a new development activity/half day course entitled "The Engaging Researcher".
Year(s) Of Engagement Activity 2012,2013,2014,2015,2016
URL http://networking.stemnet.org.uk/
 
Description The All-Ireland Hub for Trials Methodology Research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact This was an invited presentation to the Physical Activity Research Group in the Centre for Public Health, Queen's University Belfast. The presentation lasted for 45 minutes and had 15 minutes for questions at the end.

This talk promoted the existence and work of the All-Ireland Hub.
Year(s) Of Engagement Activity 2013
 
Description Unorthodox Prize for Evidence Aid 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Drawing attention to the Unorthodox prize opened opportunities for funding and stronger engagement for Evidence Aid.

Lambert Family Foundation increased their funding to Evidence Aid by $100,000 and another foundation offered 600,000 euros of funding for Evidence Aid. Additional volunteers to work with Evidence Aid.
Year(s) Of Engagement Activity 2013,2014
URL http://www.evidenceaid.org/evidence-aid-awarded-10000-unorthodox-prize-2013/
 
Description What Works Global Summit 2016, presentation Sept 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation on and promotion of the SWAT (Studies Within A Trial) and SWAR (Studies Within A Review) Programme. The presentation sparked discussion afterwards.
Year(s) Of Engagement Activity 2016
URL https://www.wwgs2016.org/
 
Description Workshops on research design for NICHS funding applicants 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other audiences
Results and Impact Prof Clarke led workshops for the NICHS to advise potential funding applicants about research design
Year(s) Of Engagement Activity 2017,2018