Enabling and translating advances in diagnostic and communication technologies to reduce the burden of STIs

Lead Research Organisation: St George's University of London
Department Name: Cellular and Molecular Medicine

Abstract

Sexually transmitted infections (STIs) are a serious health problem in the UK, particularly in young people and the Government have made tackling them an urgent priority. STIs are also becoming increasingly resistant to antibiotics, making treatment much more difficult. Untreated STIs cause serious long term consequences to those affected, such as reduced fertility. One way of improving the situation would be to use better tests that diagnose individuals in clinic, with results in 20 minutes or so, as opposed to sending samples away and waiting a few days. This allows doctors to provide immediate treatment, advice and to get patients to tell their sexual partners to get checked and treated. All this reduces the chances of spreading infection. This new consortium called eSTI2, (electronic self-testing instruments for sexually transmitted infections) aims to bring together recent scientific developments in micro-engineering, molecular biology and telecommunications, working in partnership with biotech companies to help develop new types of rapid tests for STIs. The tests could, for example, allow people to use them like a pregnancy test - ?a self-test? - and link their results to their mobile phones (safely and securely) and then electronically to clinics, so individuals can get treated quickly. This might also allow public health doctors to get a better measure of how much infection exists in the population. An important part of eSTI2 scientists? work will be to turn ?gene chips? in micro-devices (their own and those of biotech companies) into a single test that can detect many different STIs at once. eSTI2 also aims to support getting the best tests introduced into the NHS as quickly as possible. eSTI2 will set up networks of STI clinics and microbiology labs across the UK, to test how well the devices work with real life patients and get the devices properly approved. It will consult a range of people all likely to be affected by the tests, for example patients and doctors, about the best way to use them. It will also try to find the best way to combine the use of mobile phones and rapid STI tests in the community, most effectively.

Technical Summary

eSTI2 (electronic self testing instruments for sexually transmitted infections) is a multi-disciplinary consortium that aims to reduce the burden of STIs by building translational capacity to develop, improve, evaluate, adopt and facilitate the use of simple to use, rapid, accurate, polymicrobial and affordable point-of-care (PoC) and self-test mobile-phone networked micro-diagnostics. These ?eSTI2 technologies? will provide high-risk populations with easy and immediate access to STI diagnosis and treatment and make STI surveillance comprehensive and responsive. Implementation is currently hindered by: technological bottlenecks; lack of capacity to translate advances into validated commercial products; absence of single tests for multiple STI organisms; and little knowledge about the regulatory constraints, ethical challenges and health impacts of using telecommunications to personalise STI diagnosis and management. eSTI2 uniquely combines academic and industrial expertise to address these challenges through cross-disciplinary translational research and by creating trials capacity. There are 5 workstreams:
1. Translational microbiology: provides pathogen genomics and microarray expertise to evaluate DNA reporters for detecting multiple STI pathogens and antibiotic resistance markers and to incorporate these onto varied biosensor devices, with industry partners to deliver prototype PoC devices for clinical evaluation.
2. Microfluidics: will research barriers to developing microsystems and evaluate prototype devices for genital sample processing as a ?front-end? system for novel bio-sensing technologies.
3. Diagnostic Evaluation: will link the HPA?s network of GUM clinics and associated local microbiological laboratories in England, used for surveillance of HIV/STIs (GUMNet), directly to central microbiology laboratories to create sustainable capacity for clinical trials of novel diagnostics.
4. Public health impact of diagnostic interventions: will extensively assess the regulatory, clinical, governance and health-economic constraints of eSTI2 community testing and develop a wireless-web-based system for managing remote STI diagnosis. It will conduct a community-based proof-of-concept study of eSTI2 deployment in preparation for community-based trials of mobile-interfacing self-testing diagnostics.
5. Knowledge transfer and Networking: will promote: dissemination of research findings, inform on strategic challenges and sustain collaboration with industry in order to test novel diagnostic devices using the eSTI2 evaluation pipeline.

Career development in translation infection research will be provided to six interdisciplinary PhD studentships and two Academic Clinical Fellowships. Bidirectional collaboration with industry will provide financial sustainability beyond the 5 years of UKCRC funding. Impact: Significant enhancement in capacity for translational research into novel diagnostics aimed at improving treatment, reducing STI transmission and improving sexual health of high-risk groups.

Organisations

Publications

10 25 50

 
Description Bacterial Special Interest Group. Development of a Handbook of Microscopy for Diagnosing Sexually Transmitted Infections
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Biomedical Science MRes - Antimicrobial resistance
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Creating a postgraduate module in AMR improves the educational and skill level of upcoming researchers , that will inspire development and inclusion into research as a career.
 
Description Chair of the National Guidelines for the management of gonococcal infection, British Association for Sexual Health and HIV
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact As lead for the National Guidelines for the management of gonococcal infection committee for the British Association for Sexual Health and HIV, I have been responsible for discussing and disseminating opinions of key opinion leaders in the field for practitioners. Publication of the guidelines will take place later this year.
 
Description Draft National Guidelines for managment of gonorrhoea in adults
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description ECDC Report : Novel approaches to testing for sexually transmitted infections, including HIV and hepatitis B and C in Europe
Geographic Reach Asia 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Society For General Microbiology -Expert Panel on STIs
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description Detection and Identification of Infectious Agents SBRI
Amount £436,115 (GBP)
Funding ID 15933-107158 
Organisation Technology Strategy Board (TSB) 
Sector Public
Country United Kingdom
Start 09/2012 
End 02/2015
 
Description EUMinaFab
Amount £2,000 (GBP)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 02/2012 
End 02/2013
 
Description Framework 7
Amount € 3,997,530 (EUR)
Funding ID 304948 
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 06/2012 
End 06/2015
 
Description Horizon 2020 - Nanotechnologies, Advanced Materials, Biotechnology
Amount € 7,200,000 (EUR)
Funding ID 760331 
Organisation European Commission H2020 
Sector Public
Country Belgium
Start 01/2018 
End 06/2021
 
Description Invention for Innovation Programme
Amount £1,500,000 (GBP)
Funding ID II-LB-0214-20005 
Organisation National Institute for Health Research 
Department NIHR i4i Invention for Innovation (i4i) Programme
Sector Public
Country United Kingdom
Start 01/2015 
End 12/2017
 
Description MRC LID programme
Amount £65,400 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2017 
End 04/2021
 
Description Phase 2 SBRI
Amount £1,998,984 (GBP)
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 04/2017 
End 05/2020
 
Description Rapid diagnostics for human and bovine tuberculosis.
Amount £923,223 (GBP)
Organisation Technology Strategy Board (TSB) 
Sector Public
Country United Kingdom
Start 10/2013 
End 09/2016
 
Description Researcher Visibility Award
Amount £4,000 (GBP)
Organisation Brunel University London 
Sector Academic/University
Country United Kingdom
Start 11/2015 
End 06/2016
 
Description RfPB
Amount £249,734 (GBP)
Funding ID PB-PG-1014-35007 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 08/2016 
End 07/2018
 
Description SBRI
Amount £60,000 (GBP)
Organisation SBRI Healthcare 
Sector Private
Country United Kingdom
Start 09/2014 
End 08/2016
 
Description Travel Grant
Amount £2,000 (GBP)
Organisation Biochemical Society 
Sector Learned Society
Country United Kingdom
Start  
 
Description Travel Grant
Amount £500 (GBP)
Organisation Biochemical Society 
Sector Learned Society
Country United Kingdom
Start  
 
Description Wellcome Trust Institutional Strategic Support Fund Pilot Research Project Scheme
Amount £7,950 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Strategic Award
Sector Charity/Non Profit
Country United Kingdom
Start 06/2017 
End 06/2018
 
Description i4i
Amount £1,481,876 (GBP)
Funding ID II-LB-0214-20005 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 01/2015 
End 12/2018
 
Description 3QBD 
Organisation 3QBD
Country Israel 
Sector Private 
PI Contribution eSTI2 supported the evaluation of the VG sense rapid test for bacterial vaginosis. Update: Collected 142 residual female vulvo-vaginal swabs and the corresponding gram stain slide
Collaborator Contribution Work may lead to further collaborative work via the eSTI2 diagnostic pipeline
Impact -
Start Year 2013
 
Description Alere 
Organisation Alere
Country United States 
Sector Private 
PI Contribution Discussions with Alere for clinical trials within the eSTI2 pipeline for their identibac system. Transfer of multiple DNA probe sets (IP held at SGUL) for incorporation on to he CLONDIAG system. Evaluation of a lateral floe rapid test for bacterial vaginosis
Collaborator Contribution Contribution at seminars and presentations. Contributions of test kits for in clinic evaluations of rapid flow tests.
Impact Evaluation of a microscopy free pathway which incorporated the Alere lateral flow test for bacterial vaginosis. Presented at the ISSTDR in Vienna 2013. Publication in preparation. Successful grant application to the NIHR RfPB with Pippa Oakeshott as lead application, and Tariq Sadiq as co-applicant. Alere will provide 1000 tests for the study.
Start Year 2012
 
Description Aquarius Population Health 
Organisation Aquarius Population Health Ltd
Country United Kingdom 
Sector Hospitals 
PI Contribution Modelling the impact and cost-effectiveness of STI POC devices. Study idea, scoping document.
Collaborator Contribution Protocol development, modelling and cost-effectiveness analyses
Impact None yet
Start Year 2014
 
Description Atlas CT evaluations 
Organisation Atlas Genetics
Country United Kingdom 
Sector Private 
PI Contribution Atlas CT 1: Assay development: Background signal determination (n=300) - Planned (protocol development, site specific assessments, contracts, standard operating procedures, training) and implemented study 150 residual sample patients recruited between Sept-Nov 2014 (St George's clinic), 150 patient-consented sample patients recruited between Sept-Nov 2014 (Solent and Taunton clinics). Atlas CT 2: Inter-site precision study - planned and implemented. 80 synthetic samples tested in November 2015 in 4 sites: Atlas, St George's lab, Solent & Taunton clinics. Atlas CT 3: Performance evaluation for CE marking (n=1500) Planned and in final stages of implementation. 750 females recruited, and 700 males recruited to date, since Aug 2015, from 4 NHS sites (Solent, Taunton, CLCH and Chelsea & Westminster) Atlas CT 5: Assay development: Background signal determination of CT/NG assay (n=300) - Planned (protocol development, site specific assessments, contracts, standard operating procedures, training) and implemented study 150 residual sample, and 150 patient consented patients recruited in 2016 (St George's clinic),
Collaborator Contribution Atlas have inputted into protocol design for each evaluation and will provide consumables and funds to carry out the prescribed work.
Impact CT assays for females has been CE marked using data from CT1, 2 and 3. Clinical evaluation for CT/NG being conducted in USA using threshold cut off set in CT5. Development of multi STI panel being developed with Innovate UK funding including CT/NG as developed in CT 1 to 5
Start Year 2012
 
Description Atlas Genetics 
Organisation Atlas Genetics
Country United Kingdom 
Sector Private 
PI Contribution 3 evaluations have been conducted with Atlas Genetics: one for assay development (residual samples for males, patient-consented samples for females); one inter-site variability evaluation; one performance evaluation using patient-consented samples (near completion). We have 2 successful grant applications with Atlas Genetics
Collaborator Contribution Atlas Genetics has accessed the eSTI2 diagnostic pipeline.
Impact Completion of 2 studies and in final stages of a third evaluation. Data from these evaluations will be used by Atlas Genetics as part of their CE-marking submission. There have been 2 successful grant applications in collaboration with Atlas Genetics: i.) NIHR i4i grant to develop a 4-pathogen test with antimicrobial resistance detection for Neisseria gonorrhoeae and Mycoplasma genitalium (Tariq Sadiq Chief Investigator) ii.) Innovate UK SBRI grant, awarded to Atlas Genetics but written in close collaboration with eSTI2 members (lead: Tariq Sadiq), with >£100,000 of award sub-contracted to SGUL.
Start Year 2012
 
Description Axxin 
Organisation Axxin
Country Australia 
Sector Private 
PI Contribution Brunel University have thoroughly tested the ISO T16 isothermal amplification platform and provided feedback to the company on usability and operation
Collaborator Contribution Axxin have loaned Brunel University the Axxin ISO T16 Platform for over 2 years
Impact The collaboration have helped in the development of the assays for the PoC instrument developed by Brunel University
Start Year 2012
 
Description BJS Biotechnologies 
Organisation BJS Biotechnologies Ltd
Country United Kingdom 
Sector Private 
PI Contribution Brunel and BJS have collaborated in writing 2 proposals for rapid near patient Sepsis testing
Collaborator Contribution Brunel and BJS have collaborated in writing 2 proposals for rapid near patient Sepsis testing
Impact -
Start Year 2014
 
Description Becton Dickinson (BD) 
Organisation Becton, Dickinson and Company
Country United States 
Sector Private 
PI Contribution Advisory board membership
Collaborator Contribution -
Impact None
Start Year 2017
 
Description Brunel University Microfluidics / HCI Development 
Organisation Brunel University London
Department Brunel Institute for Bioengineering
Country United Kingdom 
Sector Academic/University 
PI Contribution Ongoing interaction in the eSTI2 consortium to deliver project objectives. The key elects are in the development of microfluidc platform to enable adequate sample processing for rapid NAAT detection systems. Equally the development of software (mobile and web-based to support the development of clinical care pathways. (2011-2013) We initially have worked in this collaboration in developing our Consortium Strategy Development Grant in 2008. Consortium Seminar, 20th May 2008. Held at St George's, University of London. The main purpose of this seminar was to invite potential consortium partners so as to present the vision of the UKCRC and eSTI2 consortium and to elicit interest, support, contribution and agreement to participate from collaborators across the different disciplines. One whole day seminar, comprising of a morning session explaining the proposed structure of the Consortium, timelines of development and initial plan for taking the work forward. Invitees from different disciplines including Epidemiology, Clinical Medicine, Engineering, Microfluidics, Wireless and Industry (including those from diagnostics, management and biotech) were invited to the seminar. 40 delegates attended the seminar and Workshops.
Collaborator Contribution Participated actively in developing the Consortium Strategy and is a major partner in the full Consortium Grant application. Technologies Workshop. 16th July 2008. St George's University of London. Attended by 19 delegates Topics included:- Microfluidic research questions centered on the challenges around extraction of DNA, isothermal amplification and real time detection systems. Wireless Technologies discussions centered around: • the interactive nature of devices, linking of wireless-processes within social networking; • how the devices will self power, theoretical molecular signal processing, signal detection, processing and using information and data security. • Planning the integration of existing off-the shelf POC systems and testing them in various clinical settings was a proposed area of research. Considerable time was spent discussing IT governance and, data encryption and security. A detailed discussion took place on the management structure of the consortium, the importance of microbiological leadership and capacity for microbiological training arising out of the eSTI2/UKCRC initiative. The Centre for Infections has participated actively in developing the Consortium Strategy and is a major partner in the full Consortium Grant application
Impact The final Grant Output report submitted to the MRC 2008. Please see publications list
Start Year 2008
 
Description Brunel University Microfluidics / HCI Development 
Organisation Brunel University London
Department School of Information Systems, Computing and Mathematics
Country United Kingdom 
Sector Academic/University 
PI Contribution Ongoing interaction in the eSTI2 consortium to deliver project objectives. The key elects are in the development of microfluidc platform to enable adequate sample processing for rapid NAAT detection systems. Equally the development of software (mobile and web-based to support the development of clinical care pathways. (2011-2013) We initially have worked in this collaboration in developing our Consortium Strategy Development Grant in 2008. Consortium Seminar, 20th May 2008. Held at St George's, University of London. The main purpose of this seminar was to invite potential consortium partners so as to present the vision of the UKCRC and eSTI2 consortium and to elicit interest, support, contribution and agreement to participate from collaborators across the different disciplines. One whole day seminar, comprising of a morning session explaining the proposed structure of the Consortium, timelines of development and initial plan for taking the work forward. Invitees from different disciplines including Epidemiology, Clinical Medicine, Engineering, Microfluidics, Wireless and Industry (including those from diagnostics, management and biotech) were invited to the seminar. 40 delegates attended the seminar and Workshops.
Collaborator Contribution Participated actively in developing the Consortium Strategy and is a major partner in the full Consortium Grant application. Technologies Workshop. 16th July 2008. St George's University of London. Attended by 19 delegates Topics included:- Microfluidic research questions centered on the challenges around extraction of DNA, isothermal amplification and real time detection systems. Wireless Technologies discussions centered around: • the interactive nature of devices, linking of wireless-processes within social networking; • how the devices will self power, theoretical molecular signal processing, signal detection, processing and using information and data security. • Planning the integration of existing off-the shelf POC systems and testing them in various clinical settings was a proposed area of research. Considerable time was spent discussing IT governance and, data encryption and security. A detailed discussion took place on the management structure of the consortium, the importance of microbiological leadership and capacity for microbiological training arising out of the eSTI2/UKCRC initiative. The Centre for Infections has participated actively in developing the Consortium Strategy and is a major partner in the full Consortium Grant application
Impact The final Grant Output report submitted to the MRC 2008. Please see publications list
Start Year 2008
 
Description Cepheid 
Organisation Cepheid
Country United States 
Sector Private 
PI Contribution 1. Undertaken a post market evaluation of the Cepheid GeneXpert platform 2. Undertaken clinical evaluation of the impact of GeneXpert when deployed in sexual health clinics.
Collaborator Contribution Cepheid have loaned there Gene Expert diagnostic platform and diagnostic kits to eSTI2 for the both evaluations
Impact Post market evaluations enabled CE marking of the device The clinical evaluation was presented at the ISSTDR at Vienna. Manuscript in preparation.
Start Year 2011
 
Description Chalmers Sexual Health Centre-Precise Social Science Study 
Organisation NHS Lothian
Country United Kingdom 
Sector Public 
PI Contribution please add
Collaborator Contribution please add
Impact please add
Start Year 2016
 
Description Chlamydia Sexual Behaviour and Near-Patient Testing Network 
Organisation Barts Health NHS Trust
Department Ambrose King Centre
Country United Kingdom 
Sector Hospitals 
PI Contribution Set up and liaised with sites to investigate the sexual behaviour in the time period between being tested for Chlamydia trachomatis and receiving the test result and treatment
Collaborator Contribution Sites provided data for sexual behaviour model.
Impact 1. Webtool: http://www.poctic.uk.net 2. User guide for webtool: Point-of-Care Tests for Chlamydia (POCTiC) Web-Tool: A tool for assessing the public health impact of introducing point-of-care testing for chlamydia 3. Abstracts and posters at UK Public health conference (Glasgow, November 2014); PHE Applied Epidemiology conference (Warwick, March 2015); BASHH (June 2015); ISSTDR (Brisbane, September 2015) 4. Data collection complete for study: Sexual behaviour in the time period between being tested for Chlamydia trachomatis and receiving the test result and treatment.
Start Year 2013
 
Description Chlamydia Sexual Behaviour and Near-Patient Testing Network 
Organisation Leicester Royal Infirmary
Country United Kingdom 
Sector Hospitals 
PI Contribution Set up and liaised with sites to investigate the sexual behaviour in the time period between being tested for Chlamydia trachomatis and receiving the test result and treatment
Collaborator Contribution Sites provided data for sexual behaviour model.
Impact 1. Webtool: http://www.poctic.uk.net 2. User guide for webtool: Point-of-Care Tests for Chlamydia (POCTiC) Web-Tool: A tool for assessing the public health impact of introducing point-of-care testing for chlamydia 3. Abstracts and posters at UK Public health conference (Glasgow, November 2014); PHE Applied Epidemiology conference (Warwick, March 2015); BASHH (June 2015); ISSTDR (Brisbane, September 2015) 4. Data collection complete for study: Sexual behaviour in the time period between being tested for Chlamydia trachomatis and receiving the test result and treatment.
Start Year 2013
 
Description Chlamydia Sexual Behaviour and Near-Patient Testing Network 
Organisation Royal Cornwall Hospitals NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution Set up and liaised with sites to investigate the sexual behaviour in the time period between being tested for Chlamydia trachomatis and receiving the test result and treatment
Collaborator Contribution Sites provided data for sexual behaviour model.
Impact 1. Webtool: http://www.poctic.uk.net 2. User guide for webtool: Point-of-Care Tests for Chlamydia (POCTiC) Web-Tool: A tool for assessing the public health impact of introducing point-of-care testing for chlamydia 3. Abstracts and posters at UK Public health conference (Glasgow, November 2014); PHE Applied Epidemiology conference (Warwick, March 2015); BASHH (June 2015); ISSTDR (Brisbane, September 2015) 4. Data collection complete for study: Sexual behaviour in the time period between being tested for Chlamydia trachomatis and receiving the test result and treatment.
Start Year 2013
 
Description Chlamydia Sexual Behaviour and Near-Patient Testing Network 
Organisation Royal Hallamshire Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Set up and liaised with sites to investigate the sexual behaviour in the time period between being tested for Chlamydia trachomatis and receiving the test result and treatment
Collaborator Contribution Sites provided data for sexual behaviour model.
Impact 1. Webtool: http://www.poctic.uk.net 2. User guide for webtool: Point-of-Care Tests for Chlamydia (POCTiC) Web-Tool: A tool for assessing the public health impact of introducing point-of-care testing for chlamydia 3. Abstracts and posters at UK Public health conference (Glasgow, November 2014); PHE Applied Epidemiology conference (Warwick, March 2015); BASHH (June 2015); ISSTDR (Brisbane, September 2015) 4. Data collection complete for study: Sexual behaviour in the time period between being tested for Chlamydia trachomatis and receiving the test result and treatment.
Start Year 2013
 
Description Chlamydia Sexual Behaviour and Near-Patient Testing Network 
Organisation St George's Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Set up and liaised with sites to investigate the sexual behaviour in the time period between being tested for Chlamydia trachomatis and receiving the test result and treatment
Collaborator Contribution Sites provided data for sexual behaviour model.
Impact 1. Webtool: http://www.poctic.uk.net 2. User guide for webtool: Point-of-Care Tests for Chlamydia (POCTiC) Web-Tool: A tool for assessing the public health impact of introducing point-of-care testing for chlamydia 3. Abstracts and posters at UK Public health conference (Glasgow, November 2014); PHE Applied Epidemiology conference (Warwick, March 2015); BASHH (June 2015); ISSTDR (Brisbane, September 2015) 4. Data collection complete for study: Sexual behaviour in the time period between being tested for Chlamydia trachomatis and receiving the test result and treatment.
Start Year 2013
 
Description Collaboration with Prof Phillip Cooper 
Organisation St George's University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration to develop diagnostic testing for STIs among high-risk populations (e.g. sex workers) in rural and urban areas of Ecuador.
Collaborator Contribution Capacity building and skills transfer for laboratory, epidemilology and social science work and contacts with the Ministry of Health to roll-out diagnostic testing to at-risk populations.
Impact Mulit-discplinary collaboration: laboratory and translational science, epidemilogy and social science.
Start Year 2016
 
Description Collabortation with Prof Thomas Harrison 
Organisation St George's University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution Social science expertise
Collaborator Contribution Grant applications as Co-I
Impact We have been unsuccessful in our applications for funding so far.
Start Year 2016
 
Description CromSource (formally known as Pleiad Inc) 
Organisation CROMSOURCE
Country Italy 
Sector Private 
PI Contribution -
Collaborator Contribution Crom Source (formerly Pleiad inc) have assisted eSTI2 in developing the ethical and regulatory framework for the diagnostic evaluation pipeline being created in the project.
Impact Development of the ethical and regulatory requirements. These have now been successfully approved for performing diagnostic evaluations.
Start Year 2010
 
Description DEC 
Organisation NIHR Diagnostic Evidence Co-operatve
Country United Kingdom 
Sector Public 
PI Contribution Attended DEC meetings in Newcastle and London, worked with the Oxford DEC on developing novel diagnostic with Atlas Genetics
Collaborator Contribution Knowledge for the Atlas Genetics diagnostic. Imperial DEC has presented at the Brunel Diagnostics for the Developing world conference supported by eSTI2
Impact DDW conference
Start Year 2015
 
Description DREAMM Project: Development of nanopore sequencing for detecting causes of meningitis 
Organisation Oxford Nanopore Technologies
Country United Kingdom 
Sector Private 
PI Contribution Dr Sadiq initiated a collaboration with Dr Angela Loise to work together on the DREAMM project in sub-saharan Africa.
Collaborator Contribution Dr Sadiq contributed to 3 unsuccessful grant applications for the use of nanopore sequencing, however a PhD stuedntship has now been funded to work on this project.
Impact A PhD studentship. Presetation of DREAMM at New York Nanopore meeting; Presentation of eSTI2 project by Dr Sadiq at DREAMM
Start Year 2017
 
Description DREAMM collaborations 
Organisation St George's University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution Laboratory science and social science expertise. Initiations of collaborations by Dr Sadiq with dr Angela Loise - linking in Dr Sebastian Fuller
Collaborator Contribution Social science: implementation of focus group discussions with medical professionals to better understand non-adherance to diagnostic procedures, resulting in high patient morbitiy. This work enabled the diagnostic pathway teaching to be tailored to the needs identified by the medical professionals. Work is ongoing.
Impact Work is ongoing
Start Year 2017
 
Description Epigenyses - Collaborative development of a web-based clinic care pathway for managing Chlamydia trachoma tis infection 
Organisation University of Sheffield
Department epiGenesys Ltd
Country United Kingdom 
Sector Private 
PI Contribution The workstream led by Dr Claudia Estcourt at QMUL, Dr Pam Sonnenberg at UCL, Dr Kate Hone at Brunel University, Professor Ala Szczepura at Warwick University and Dr Tariq Sadiq at St George's University have developed the Chlamydia Online Clinical Care Pathway system software in collaboration with the software company Epigenesys.
Collaborator Contribution They have developed the software in from the specification and wireframe developed by the team.
Impact The first pilot exploratory study was completed in March 2015and presented at ISSTDR 2015.
Start Year 2012
 
Description Epistem 
Organisation Epistem
Country United Kingdom 
Sector Private 
PI Contribution Development of a research proposal and discussion on translating probes to their diagnostic platform
Collaborator Contribution Joint research proposal
Impact Research proposal to NIHR initiated
Start Year 2011
 
Description Health Protection Agency -Surveillance and Diagnostic Evaluation 
Organisation Public Health England
Department Centre of Infectious Disease Surveillance and Control
Country United Kingdom 
Sector Public 
PI Contribution We have worked in this collaboration in developing our Consortium strategy. Involvement (Scientific Steering Committee) with PHE Innovate UK SBRI grant (Development of a tool for assessment of the impact of introduction of point-of-care tests for STIs), with 2 main projects: i.) Development of a user-friendly webtool to assess the cost and epidemiological impact of implementing point of care tests for chlamydia at the local level; ii.) Investigating sexual behaviour in the time period between being tested for chlamydia and receiving test result and treatment. Systematic review of rectal Chlamydia.
Collaborator Contribution The Centre for Infections has participated actively in developing the Consortium Strategy and is a major partner in the full Consortium Grant application
Impact Development of a distinct strategy for Translational Infection Research. The final Grant Output report submitted to the MRC 2008. Please see publications and grants
Start Year 2008
 
Description International University of Ecuador 
Organisation International University of Ecuador
PI Contribution This has been a substantive collaboration with Dr Natalia Romero of IUDE. We have completed a study o female sex workers - funded jointly by SGUL and IUDE investigating epidemiology of four STIS and the use of rapid test technologies in changing outcomes.
Collaborator Contribution Intial discussion with Atlas on providing rapid test technologies - finally provided by Cepheid
Impact Abstracts submitted to IUSTI 2018 Conference in Dublin; Wellcome trust grant applications made; manuscript being prepared.
Start Year 2017
 
Description Kings College London 
Organisation King's College Hospital NHS Foundation Trust (NCH)
Country United Kingdom 
Sector Academic/University 
PI Contribution Brining in KCL into the network of clinics to perform diagnostic and clinical evaluations.
Collaborator Contribution Collection of residual STI2 samples and collaboration within the eSTI2 programme of work
Impact Definition of ethical protocols. See publications - evaluation of microscopy free pathways presented at Vienna ISSTDR 2013
Start Year 2011
 
Description Knight Scientific 
Organisation Knight Scientific Ltd
Country United Kingdom 
Sector Private 
PI Contribution Discussions on the potential for evaluating the rapid platform for inflammation
Collaborator Contribution Entry to the eSTI2 diagnostic pipeline
Impact Agreement in development
Start Year 2013
 
Description LSHTM 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Impact of mass drug administration with azithromycin on STI prevalence and resistance profiles Study idea, protocol development, sample testing for M. genitalium presence and antimicrobial resistance. Discussions regarding future work in developing countries
Collaborator Contribution Protocol development, sample provision. Discussions regarding future work in developing countries
Impact None yet
Start Year 2013
 
Description Lambeth College Chlamydia Testing 
Organisation Cepheid
Country United States 
Sector Private 
PI Contribution Planned and implemented a day of opportunistic Chlamydia testing in an inner London further education college
Collaborator Contribution Lambeth College provided access to the college and students. St George's NHS Trust provided follow up to students who were diagnosed positive for Chlamydia. Cepheid provided a testing platform and 50 cartridges.
Impact Publication: Sharman N1, Sri T1, Chow C2, Pond MJ2, Oakeshott P1, Planche T3, Sadiq ST4.Chlamydia testing: Reaching high-risk sexually active young people in the community. Int J STD AIDS. Epub 2015 Apr 29. 2016 Jan;27(1):78-9.
Start Year 2013
 
Description Lambeth College Chlamydia Testing 
Organisation Lambeth College
Country United Kingdom 
Sector Academic/University 
PI Contribution Planned and implemented a day of opportunistic Chlamydia testing in an inner London further education college
Collaborator Contribution Lambeth College provided access to the college and students. St George's NHS Trust provided follow up to students who were diagnosed positive for Chlamydia. Cepheid provided a testing platform and 50 cartridges.
Impact Publication: Sharman N1, Sri T1, Chow C2, Pond MJ2, Oakeshott P1, Planche T3, Sadiq ST4.Chlamydia testing: Reaching high-risk sexually active young people in the community. Int J STD AIDS. Epub 2015 Apr 29. 2016 Jan;27(1):78-9.
Start Year 2013
 
Description Lambeth College Chlamydia Testing 
Organisation St George's NHS Trust, London
Country United Kingdom 
Sector Public 
PI Contribution Planned and implemented a day of opportunistic Chlamydia testing in an inner London further education college
Collaborator Contribution Lambeth College provided access to the college and students. St George's NHS Trust provided follow up to students who were diagnosed positive for Chlamydia. Cepheid provided a testing platform and 50 cartridges.
Impact Publication: Sharman N1, Sri T1, Chow C2, Pond MJ2, Oakeshott P1, Planche T3, Sadiq ST4.Chlamydia testing: Reaching high-risk sexually active young people in the community. Int J STD AIDS. Epub 2015 Apr 29. 2016 Jan;27(1):78-9.
Start Year 2013
 
Description Lloyds Pharmacy 
Organisation Lloyds Pharmacy
Country United Kingdom 
Sector Private 
PI Contribution Lloyds Pharmacy are the preferred provider of prescription services within the community trials for STI point of care diagnostics
Collaborator Contribution Lloyds Pharmacy are happy to be associated with the eSTI2 programme, with seven of thirty pharmacies participating in the Chlamydia Online Clinical Care Pathway exploratory study.
Impact Barriers to successful pharmacy provision of prepacked antibiotics identified
Start Year 2012
 
Description Microbial community profiling 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Metagenomic library preparation from DNA extracted from genital samples that are well characterised with immunological and clinical data for microbial community profiling Optimisation of 16S rDNA PCR with primers provided by the Wellcome Trust Sanger Institute Metagenomic data analysis plan
Collaborator Contribution Protocol guidance for metagenomic library preparation Primers for 16S rDNA PCR Sequencing of amplicons Metagenomic data analysis plan
Impact The collaboration was set up in September 2014 and preliminary work on the sequencing from urine samples is currently being done. This is a multidisciplinary collaboration including genitourinary medicine, microbiology, genomics and bioinformatics.
Start Year 2014
 
Description Microbial community profiling 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Metagenomic library preparation from DNA extracted from genital samples that are well characterised with immunological and clinical data for microbial community profiling Optimisation of 16S rDNA PCR with primers provided by the Wellcome Trust Sanger Institute Metagenomic data analysis plan
Collaborator Contribution Protocol guidance for metagenomic library preparation Primers for 16S rDNA PCR Sequencing of amplicons Metagenomic data analysis plan
Impact The collaboration was set up in September 2014 and preliminary work on the sequencing from urine samples is currently being done. This is a multidisciplinary collaboration including genitourinary medicine, microbiology, genomics and bioinformatics.
Start Year 2014
 
Description Microbial community profiling in the POPI study 
Organisation St George's University of London
Department Bacterial Microarray Group at St George's (BµG@S)
Country United Kingdom 
Sector Academic/University 
PI Contribution Sample preparation protocol Metagenomic sequencing protocol Data analysis plan
Collaborator Contribution Grant proposal Contribution of samples from the POPI study
Impact Funding for the metagenomic work is being sought
Start Year 2014
 
Description Microbial community profiling in the POPI study 
Organisation St George's University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution Sample preparation protocol Metagenomic sequencing protocol Data analysis plan
Collaborator Contribution Grant proposal Contribution of samples from the POPI study
Impact Funding for the metagenomic work is being sought
Start Year 2014
 
Description Microcapillary microfluidic detection assays 
Organisation Loughborough University
Country United Kingdom 
Sector Academic/University 
PI Contribution Sample characterisation Plan for comparison of cytokine detection by standard methods with a fluoropolymer microcapillary device Clinical study protocol development
Collaborator Contribution Plan for multiplex detection of cytokines on a rapid fluoropolymer microcapillary device using initially a flurophore and later on colourimetric methods to enable mobile phone reading
Impact Currently ongoing. Funding for this project has been sought by Loughborough university
Start Year 2014
 
Description Microcapillary microfluidic detection assays 
Organisation University of Reading
Country United Kingdom 
Sector Academic/University 
PI Contribution Sample characterisation Plan for comparison of cytokine detection by standard methods with a fluoropolymer microcapillary device Clinical study protocol development
Collaborator Contribution Plan for multiplex detection of cytokines on a rapid fluoropolymer microcapillary device using initially a flurophore and later on colourimetric methods to enable mobile phone reading
Impact Currently ongoing. Funding for this project has been sought by Loughborough university
Start Year 2014
 
Description MiniFab 
Organisation MiniFab
PI Contribution In discussion to manufacture microfluidic device for eSTI2 PoC platform
Collaborator Contribution MiniFab have provided advice on the manufacture of microfluidic cartridges and reagent delivery
Impact Redesign for manufacture of microfluidic cartridge for PoC instrument
Start Year 2013
 
Description Ministry of Public Health - Ecuador 
Organisation Ministry of Public Health
Country Lebanon 
Sector Public 
PI Contribution Writing research proposals for development of new diagnostics and implementation in resource poor settings
Collaborator Contribution Writing research proposals for development of new diagnostics and implementation in resource poor settings
Impact Grant applications
Start Year 2016
 
Description Mologic 
Organisation Mologic
Country United Kingdom 
Sector Private 
PI Contribution Planned and implemented, monitored and analysed data for Mologic BV assay early stage evaluation. Provided clinical samples
Collaborator Contribution Tested samples provided
Impact Product development has progress to next stage from evaluation undertaken. Potential for further evaluations for other infectious diseases
Start Year 2016
 
Description Moorlodge Biotech Ventures (now Healthcare Diagnostics (HCD)) 
Organisation Moorlodge Biotech Ventures
Country United Kingdom 
Sector Private 
PI Contribution This is a translational collaboration. eSTI2 has transferred probes for detection of sexually transmitted diseases to HCD for incorporation onto their point of care diagnostic platform. Update: A total of 431 residual samples have been collected. Visits have been made to HCD to help with troubleshooting. Testing of the device is ongoing.
Collaborator Contribution HCD will access the eSTI2 diagnostic pipeline.
Impact Demonstrated the commitment made in the proposal to translate bio markers to companies. Work is ongoing to move to the next phase transferring Healthcare Diagnostics into the Diagnostic Evaluation workstream, to do an initial performance evaluation using residual samples.
Start Year 2010
 
Description NICE 
Organisation National Institute for Health and Care Excellence (NICE)
Country United Kingdom 
Sector Public 
PI Contribution The NICE Medical technologies evaluation programme (MTEP) selects and evaluates new or innovative medical technologies (including devices and diagnostics). MTEP helps the NHS adopt efficient and cost effective medical devices and diagnostics more rapidly and consistently. Meeting to discuss future partnership between NICE & eSTI2 in MTEP
Collaborator Contribution Meeting to discuss future partnership between NICE & eSTI2
Impact None yet
Start Year 2011
 
Description Nanopore 
Organisation Oxford Nanopore Technologies
Country United Kingdom 
Sector Private 
PI Contribution This is a significant collaboration - we (Dr Sadiq's team) have worked with Oxford Nanopore to sequence a number of gonorrhoea isolates at their laboratories and at ours at St George's and to secure value in kind contributions of equipment to sequence clinical samples. The results of these are now being prepared for publication. The results of the gonorrhoea isolates have been presented at numerous international conferences by Dr Sadiq.
Collaborator Contribution please add - this work was conducted beween St George's and Oxford Nanopore
Impact Conference outputs at the ISSTDR 2017 Rio de Janeiro; Australasian Sexual Health Conference; Newton Funded workshop on antimicrobial resistance
Start Year 2016
 
Description Oxford Gene Technology - STI Polymicrobial Array 
Organisation Oxford Gene Technology
Country United Kingdom 
Sector Private 
PI Contribution We have clinically evaluated the utility of a 28 organism -polymicrobial STI array for diagnosing multiple sexually transmitted infections. The array was designed in collaboration with Oxford Gene Technology.
Collaborator Contribution OGT have provided intellectual input into the design of our polymicrobial STI array and supportive to the subsequent bid for a full Consortium Grant. OGT have participated in workshops and seminars in developing the strategy for the Consortium.
Impact Development and Validation of a Microarray Enabling Simultaneous Detection of MultipleSexually Transmitted Infections. Division of Cellular and Molecular Medicine, St George's, University of London. Oxford Gene Technology, Begbroke Science Park, Yarnton, Oxford MRC Biostatistics Unit, Institute of Public Health, Cambridge Department of Genitourinary Medicine, St George's Healthcare NHS Trust. Publication - In preparation of the above Title
Start Year 2007
 
Description QMUL 
Organisation Queen Mary University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution Joint development of Community Trials for eSTI2 Consortium
Collaborator Contribution Leading on the development of community trials
Impact On-going collaboration
Start Year 2011
 
Description Qiagen 
Organisation Qiagen
Country Netherlands 
Sector Private 
PI Contribution Qiagen Artus Trichomonas vaginalis test evaluation. Qiagen are developing a TV diagnostic test, which they have asked us to evaluate once it has received CE-marking. eSTI2 diagnostic pipeline, protocol development, ethical approval
Collaborator Contribution Loan of instrumentation
Impact None yet
Start Year 2014
 
Description QuantumDx 
Organisation QuantuMDx Group Limited
Country United Kingdom 
Sector Private 
PI Contribution This is an ongoing relationship to transfer genetic markers from eSTI2 to QuantumDx. Residual STI patient samples will then be used to evaluate their sensor technology.
Collaborator Contribution Collaboration with QuantumDx enables eSTI2 to meet its research objectives
Impact This will enable eSTI2 to exercise the diagnostic evaluation protocols it is developing as part of the translational research. Two grants enabled: Nanomal and TSB grant for TB
Start Year 2011
 
Description Quidel LTF technology for BV 
Organisation Quidel
Country United States 
Sector Private 
PI Contribution Provided linkages to UK services for planned evaluations.
Collaborator Contribution Quidel will access the eSTI2 diagnostic pipeline.
Impact None as yet
Start Year 2014
 
Description Safeguard 
Organisation Safeguard Biosystems
Country United Kingdom 
Sector Private 
PI Contribution Discussion on the provision of probes for their array based multi-pathogen diagnostic tool
Collaborator Contribution None to date
Impact None to date
Start Year 2012
 
Description Sanger- sequencing 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Genomewide Association study to investigate the genetic determinant of penicillin resistance in circulation strains of Neisseria Gonorrhoeae. This study hs progressed after siginificant delays due to contractual discussion between institutions. Samples are ready now for sequencing.
Collaborator Contribution To determine predictive genotypic markers of penicillin or other antimicrobials of interest resistance by whole genome sequencing of 700 gonorrhoea isolates
Impact please add
Start Year 2017
 
Description SpeedDx 
Organisation SpeedDX Pty
Country Australia 
Sector Private 
PI Contribution Planning and implementation of evaluation of Mycoplasma genitalium assay. Study ongoing.
Collaborator Contribution SpeedDx is accessing the eSTI2 diagnostic pipeline
Impact No outcomes yet
Start Year 2015
 
Description TwistDx 
Organisation TwistDx
Country United Kingdom 
Sector Private 
PI Contribution Supply of residual STI patient samples for testing of their Chlamydia assay. Four evaluations have taken place (1 using residual samples, 3 using patient-consented samples) to enable assay development. Developed robust protocols, planned logistics and successfully implemented within commercial timelines: 1) TwistDX PCE1 residual sample study (100 samples) (St Georges Courtyard Clinic; 2)TwistDx PCE 2 Swab selection study - Clinics: St George's, King's and Dorset - 69 patients recruited 3) TwistDx PCE 3 Background signal determination - Clinics: St George's, Solent and Bradford - 840 patients recruited 4) PCE 3.1 Impact of size exclusion column. Twist and Brunel University have submitted a Horizon 2020 funding application on paper microfluiidcs
Collaborator Contribution TwistDx have accessed the eSTI2 diagnostic evaluation pipeline. TwistDx provided consumables and funds to reimburse sites and planning/implementation time incurred. TwistDx have provided 200 CT assays for development of the eSTI2 point of care platform
Impact Peer-review publication in preparation. Conference abstracts
Start Year 2011
 
Description UCL - Epidemiolgy and Public Health Workstreams 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Contributing to the development of clinical care pathways. Consortium Seminar and various workshops.
Collaborator Contribution Development of clinical care pathways for eSTI2. Epidemiology/Clinical Workshop 18th June 2008. Held at St George's University of London. Attended by 12 delegates from SGUL, UCL, University of Sussex Key areas that were discussed included: 1. The direction of the Consortium 2. Distillation of a diverse number of clinical and epidemiological research proposals that would be needed to underpin the work of the Consortium. 3. The structure of the consortium, leadership and institutional support were also discussed in detail.
Impact MRC Report Submitted 2008 See publications list
Start Year 2008
 
Description WHO collaboration for technical specifications on point-to-point care tests for STIs. 
Organisation World Health Organization (WHO)
Country Global 
Sector Public 
PI Contribution Took part in 3-day consultation at the WHO's 1st technical consultation on point-to-point care tests for STIs to develop technical specifications for industry development of point-of-care tests for STIs.
Collaborator Contribution Organised and brought together world specialists
Impact Technical specifications for industry development of point-of-care tests for STIs.
Start Year 2014
 
Description eSTI2 Diagnostic Evaluations Network 
Organisation Bradford Teaching Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution We have continued to build this network through eSTI2 links e.g. GUMnet, SWAGnet and through CLRN. We have provided clinical sites with as much training and support as needed to deliver a variety of diagnostic evaluations and am able to help build research capacity where needed.
Collaborator Contribution Clinics have recruited patients and provided clinical samples and data for diagnostic evaluations
Impact We have successfully delivered a series of commercial diagnostic evaluations with the help of this network.
Start Year 2013
 
Description eSTI2 Diagnostic Evaluations Network 
Organisation Central London Community Healthcare NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution We have continued to build this network through eSTI2 links e.g. GUMnet, SWAGnet and through CLRN. We have provided clinical sites with as much training and support as needed to deliver a variety of diagnostic evaluations and am able to help build research capacity where needed.
Collaborator Contribution Clinics have recruited patients and provided clinical samples and data for diagnostic evaluations
Impact We have successfully delivered a series of commercial diagnostic evaluations with the help of this network.
Start Year 2013
 
Description eSTI2 Diagnostic Evaluations Network 
Organisation Chelsea and Westminster Hospital NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution We have continued to build this network through eSTI2 links e.g. GUMnet, SWAGnet and through CLRN. We have provided clinical sites with as much training and support as needed to deliver a variety of diagnostic evaluations and am able to help build research capacity where needed.
Collaborator Contribution Clinics have recruited patients and provided clinical samples and data for diagnostic evaluations
Impact We have successfully delivered a series of commercial diagnostic evaluations with the help of this network.
Start Year 2013
 
Description eSTI2 Diagnostic Evaluations Network 
Organisation Dorset County Hospital NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution We have continued to build this network through eSTI2 links e.g. GUMnet, SWAGnet and through CLRN. We have provided clinical sites with as much training and support as needed to deliver a variety of diagnostic evaluations and am able to help build research capacity where needed.
Collaborator Contribution Clinics have recruited patients and provided clinical samples and data for diagnostic evaluations
Impact We have successfully delivered a series of commercial diagnostic evaluations with the help of this network.
Start Year 2013
 
Description eSTI2 Diagnostic Evaluations Network 
Organisation Hertfordshire Community NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution We have continued to build this network through eSTI2 links e.g. GUMnet, SWAGnet and through CLRN. We have provided clinical sites with as much training and support as needed to deliver a variety of diagnostic evaluations and am able to help build research capacity where needed.
Collaborator Contribution Clinics have recruited patients and provided clinical samples and data for diagnostic evaluations
Impact We have successfully delivered a series of commercial diagnostic evaluations with the help of this network.
Start Year 2013
 
Description eSTI2 Diagnostic Evaluations Network 
Organisation North East London NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution We have continued to build this network through eSTI2 links e.g. GUMnet, SWAGnet and through CLRN. We have provided clinical sites with as much training and support as needed to deliver a variety of diagnostic evaluations and am able to help build research capacity where needed.
Collaborator Contribution Clinics have recruited patients and provided clinical samples and data for diagnostic evaluations
Impact We have successfully delivered a series of commercial diagnostic evaluations with the help of this network.
Start Year 2013
 
Description eSTI2 Diagnostic Evaluations Network 
Organisation Solent NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution We have continued to build this network through eSTI2 links e.g. GUMnet, SWAGnet and through CLRN. We have provided clinical sites with as much training and support as needed to deliver a variety of diagnostic evaluations and am able to help build research capacity where needed.
Collaborator Contribution Clinics have recruited patients and provided clinical samples and data for diagnostic evaluations
Impact We have successfully delivered a series of commercial diagnostic evaluations with the help of this network.
Start Year 2013
 
Description eSTI2 Diagnostic Evaluations Network 
Organisation St George's NHS Trust, London
Country United Kingdom 
Sector Public 
PI Contribution We have continued to build this network through eSTI2 links e.g. GUMnet, SWAGnet and through CLRN. We have provided clinical sites with as much training and support as needed to deliver a variety of diagnostic evaluations and am able to help build research capacity where needed.
Collaborator Contribution Clinics have recruited patients and provided clinical samples and data for diagnostic evaluations
Impact We have successfully delivered a series of commercial diagnostic evaluations with the help of this network.
Start Year 2013
 
Description eSTI2 Diagnostic Evaluations Network 
Organisation Taunton and Somerset NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution We have continued to build this network through eSTI2 links e.g. GUMnet, SWAGnet and through CLRN. We have provided clinical sites with as much training and support as needed to deliver a variety of diagnostic evaluations and am able to help build research capacity where needed.
Collaborator Contribution Clinics have recruited patients and provided clinical samples and data for diagnostic evaluations
Impact We have successfully delivered a series of commercial diagnostic evaluations with the help of this network.
Start Year 2013
 
Description eSTI2 PolySTI clinical network 
Organisation Guy's and St Thomas' NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Site set up R&D approvals Site training Site monitoring Patient recruitment, Sample collection, Data collection Sample preservation and transport
Collaborator Contribution Patient recruitment, Sample collection, Data collection
Impact Patient recruitment commenced in May 2012 initially at the Courtyard clinicand later in 2014 at the Roehampton clinic, the Burrell street clinic and at the Kingsway centre in Stevenage. Orsett Hospital, West Middlesex Hospital and Northern Devon NHS Trust are currently in the set up stage with feasibility analyses ongoing. Southend-on-sea has also expressed an interest to join the stuidy.
Start Year 2012
 
Description eSTI2 PolySTI clinical network 
Organisation Hertfordshire Community NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution Site set up R&D approvals Site training Site monitoring Patient recruitment, Sample collection, Data collection Sample preservation and transport
Collaborator Contribution Patient recruitment, Sample collection, Data collection
Impact Patient recruitment commenced in May 2012 initially at the Courtyard clinicand later in 2014 at the Roehampton clinic, the Burrell street clinic and at the Kingsway centre in Stevenage. Orsett Hospital, West Middlesex Hospital and Northern Devon NHS Trust are currently in the set up stage with feasibility analyses ongoing. Southend-on-sea has also expressed an interest to join the stuidy.
Start Year 2012
 
Description eSTI2 PolySTI clinical network 
Organisation North East London NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Site set up R&D approvals Site training Site monitoring Patient recruitment, Sample collection, Data collection Sample preservation and transport
Collaborator Contribution Patient recruitment, Sample collection, Data collection
Impact Patient recruitment commenced in May 2012 initially at the Courtyard clinicand later in 2014 at the Roehampton clinic, the Burrell street clinic and at the Kingsway centre in Stevenage. Orsett Hospital, West Middlesex Hospital and Northern Devon NHS Trust are currently in the set up stage with feasibility analyses ongoing. Southend-on-sea has also expressed an interest to join the stuidy.
Start Year 2012
 
Description eSTI2 PolySTI clinical network 
Organisation Northern Devon Healthcare NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution Site set up R&D approvals Site training Site monitoring Patient recruitment, Sample collection, Data collection Sample preservation and transport
Collaborator Contribution Patient recruitment, Sample collection, Data collection
Impact Patient recruitment commenced in May 2012 initially at the Courtyard clinicand later in 2014 at the Roehampton clinic, the Burrell street clinic and at the Kingsway centre in Stevenage. Orsett Hospital, West Middlesex Hospital and Northern Devon NHS Trust are currently in the set up stage with feasibility analyses ongoing. Southend-on-sea has also expressed an interest to join the stuidy.
Start Year 2012
 
Description eSTI2 PolySTI clinical network 
Organisation St George's Healthcare NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution Site set up R&D approvals Site training Site monitoring Patient recruitment, Sample collection, Data collection Sample preservation and transport
Collaborator Contribution Patient recruitment, Sample collection, Data collection
Impact Patient recruitment commenced in May 2012 initially at the Courtyard clinicand later in 2014 at the Roehampton clinic, the Burrell street clinic and at the Kingsway centre in Stevenage. Orsett Hospital, West Middlesex Hospital and Northern Devon NHS Trust are currently in the set up stage with feasibility analyses ongoing. Southend-on-sea has also expressed an interest to join the stuidy.
Start Year 2012
 
Description eSTI2 PolySTI clinical network 
Organisation West Middlesex University Hospital NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution Site set up R&D approvals Site training Site monitoring Patient recruitment, Sample collection, Data collection Sample preservation and transport
Collaborator Contribution Patient recruitment, Sample collection, Data collection
Impact Patient recruitment commenced in May 2012 initially at the Courtyard clinicand later in 2014 at the Roehampton clinic, the Burrell street clinic and at the Kingsway centre in Stevenage. Orsett Hospital, West Middlesex Hospital and Northern Devon NHS Trust are currently in the set up stage with feasibility analyses ongoing. Southend-on-sea has also expressed an interest to join the stuidy.
Start Year 2012
 
Description eSTI2 PolySTI metabolomics 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Vaginal swab elute preparation for NMR spectrometry Performing NMR spectroscopy on the prepared samples at UCL premises NMR spectra data analysis plan
Collaborator Contribution Sample preparation protocol for NMR spectrometry analysis NMR spectra data analysis
Impact Sample preparation is currently ongoing with preliminary NMR spectrometry optimisation experiments planned to start imminently
Start Year 2014
 
Description iBOSSolutions 
Organisation iBOSSolutions Ltd
Country United Kingdom 
Sector Private 
PI Contribution eSTI2 and iBOS are partnering to translate the remote clinical pathway developed within eSTI2 to the commercial sphere.
Collaborator Contribution IBOSS are helping with defining the security protocols and system architecture requirements for a series of pilot trials of the eSTI2 diagnostic pathway
Impact Definition of the system architecture requirements. Disciplines involved: Computer science, human computer interaction, medical diagnostics
Start Year 2011
 
Title know how for the e Sexual Health Clinic 
Description The development of the e-SHC between partners of the eSTI2 Consortium. License has been given to QMUL to commercialise this further. 
IP Reference  
Protection Protection not required
Year Protection Granted
Licensed Yes
Impact Nil so far
 
Title Atlas CT1A 
Description Provision of 150 male residual samples for Atlas CT assay development 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Initial development
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact STI2 has developed a process and infrastructure where third parties can access independent clinical evaluations. This infrastructure includes provision of samples to clinical trials. This evaluation / provision of samples is to work with clients to develop the capability. 
 
Title Atlas CT1B 
Description Provision of 150 patient consented female samples for assay development. 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Initial development
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact STI2 has developed a process and infrastructure where third parties can access independent clinical evaluations. This infrastructure includes provision of samples to clinical trials. This evaluation / provision of samples is to work with clients to develop the capability. 
 
Title Atlas CT3 
Description Diagnostic performance evaluation of 750 female patient-consented samples, and 750 male urine samples 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Market authorisation
Year Development Stage Completed 2016
Development Status Under active development/distribution
Impact The full spectrum of evaluation has been demonstrated from early assay development via clinical samples through to diagnostic performance evaluation for CE marking. This has lead to the setup of a diagnostic evaluation service run from St Georges University London called the Applied Diagnostic Research and Evaluation Unit (ADREU) 
 
Title Cepheid Gene Expert 1 
Description eSTI2 has completed a 50 patient residual sample study using the Cepheid GeneXpert platform that rapidly diagnoses gonorrhoea and chlamydia by NAAT 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2013
Development Status Under active development/distribution
Impact STI2 has developed a process and infrastructure where third parties can access independent clinical evaluations. This infrastructure includes provision of samples to clinical trials. This evaluation / provision of samples is to work with clients to develop the capability. 
 
Title Cepheid Gene Expert 2 
Description eSTI2 completed for the Cepheid GeneXpert an evaluation of health provision, outcomes and patient perspectives to assess the impact of introducing Cepheid GeneXpert into a sexual health clinic 
Type Diagnostic Tool - Imaging
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2013
Development Status Under active development/distribution
Impact STI2 has developed a process and infrastructure where third parties can access independent clinical evaluations. This infrastructure includes provision of samples to clinical trials. This evaluation / provision of samples is to work with clients to develop the capability. 
 
Title Healthcare diagnostics 
Description Healthcare diagnostics are developing a rapid test platform as a diagnostic tool. eSTI2 have supplied 3 sets of residual urine samples (total 966 samples) for CT assay development 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Initial development
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact STI2 has developed a process and infrastructure where third parties can access independent clinical evaluations. This infrastructure includes provision of samples to clinical trials. This evaluation / provision of samples is to work with clients to develop the capability. 
 
Title Twist PCE1 
Description Development of a rapid point of care Chlamydia & Gonorrhoea diagnostic tool. TwistDx Ltd were supplied with 100 residual urine samples for the aim of developing their Recombinase Polymerase Amplification (RPA) based assay. 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Initial development
Year Development Stage Completed 2012
Development Status Under active development/distribution
Impact eSTI2 has developed a process and infrastructure where third parties can access independent clinical evaluations. This infrastructure includes provision of samples to clinical trials. This evaluation / provision of samples is to work with clients to develop the capability. 
 
Title TwistDx PCE2 
Description Subsequent to evaluation Twist PCE1 an additional patient consented sample collection was undertaken to enable TwistDx to choose the appropriate swab for female sample collection for their Chlamydia & Gonorrhoea diagnostic tool. 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Initial development
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact STI2 has developed a process and infrastructure where third parties can access independent clinical evaluations. This infrastructure includes provision of samples to clinical trials. This evaluation / provision of samples is to work with clients to develop the capability. 
 
Title TwistDx PCE3 
Description eSTI2 has collected over 800 patient consented samples to enable assay development / evaluation of the TwsitDX RPA assay. The samples have been provided to TwistDx via a service agreement 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact Part of the eSTI2 evaluation development infrastructure rollout. 
 
Title A web-tool for managing Chlamydia infection diagnosed in the community 
Description This is a web-application tool developed in collaboration between eSTI2 partners (QMUL, UCL, Brunel, Warwick and SGUL) that allows patients who receive their Chlamydia diagnosis while outside clinic via text to access care and treatment without having to re-attend clinic. It is electronically linked to pharmacies and has built in safeguards to prevent patients inappropriately accessing the pathway (e.g. those with potential complications of infection) and that enable patients to link in with healthcare workers at any part of the pathway. Pilot trials undertaken in collaboration with the National Chlamydia Screening Programme, Barts and The London Healthcare Trust and St George's Healthcare NHS Trust, have now been completed. 
Type Of Technology Webtool/Application 
Year Produced 2015 
Impact Nil yet 
 
Title POC Mobile Phone Reader 
Description Software enabling mobile phone cameras to interact with rapid diagnostic tests 
Type Of Technology Webtool/Application 
Year Produced 2014 
Impact Nil yet 
 
Title POCTIC 
Description This tool, which is part- funded by the Grant and also by Innovate UK, allows for industry and Healthcare commissioners to understand the cost and epidemiologic impact of introducing point of care testing into their local setting in the UK. Variables include local prevalence of infection as well as putative accuracies of the tests being introduced. 
Type Of Technology Webtool/Application 
Year Produced 2014 
Impact nil yet 
 
Title PolySTI computer assisted self-interview for behaviour 
Description This is an behaviour questionnaire that is intuitively administered by an algorithm to collect data on sexual behaviour and socioeconomic status anonymously. 
Type Of Technology Webtool/Application 
Year Produced 2013 
Impact Data collection underway 
 
Description ADREU Twitter 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The ADREU Twitter account was created to allow our group to increase visiblity among potential new and exisiting collaborators and clients.
Year(s) Of Engagement Activity 2017,2018
URL https://twitter.com/adreu_sgul
 
Description ADREU website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact The ADREU website was created to enable our group to provide information on our services and allow for Industry and professionals easily contact us and/or request further information to collaborate with our group.
Year(s) Of Engagement Activity 2016,2017,2018
URL http://www.adreu.com/
 
Description AMR Information and Networking Event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact AMR Information and Networking Event "Antimicrobial resistance: behaviour within and beyond the healthcare setting", Amba Hotel Marble Arch, London, Tuesday 14 June 2016. Presentation "A clinician's perspective" presented by Dr Tariq Sadiq
Year(s) Of Engagement Activity 2016
 
Description AMR workshop at Heathrow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact this was a networking meeting discussing potential collaboration with a number of industrial and academic partners
Year(s) Of Engagement Activity 2017
 
Description Abbott-USA 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Discussion for the potential of using clnical samples for early phase testing of a new technology
Year(s) Of Engagement Activity 2018
 
Description Achieving a World Without Medication Error 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Gibbs J, Sutcliffe L, Aicken C, Tickle L, Wu S, Shimmin H, Ashcroft RE, Sadiq ST, Sonnenberg P, Estcourt C. A novel ePrescribing System linking an online eSexual Health Clinic & Community Pharmacies.
Achieving a World Without Medication Error: e-Prescribing and Medication Management Symposium, School of Pharmacy, UCL. 25th November 2016.
Year(s) Of Engagement Activity 2016
 
Description Alere 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Industry/Business
Results and Impact Alere wanted to discuss potential collaboration opportunities for their new diagnostic device
Year(s) Of Engagement Activity 2018
 
Description BASHH 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Poster and oral presentations:
""Can I get treated online?" Using the eClinical Care Pathway Framework to develop an evidence based online clinical care pathway for management of people with genital chlamydia"
"Sexual behaviour in the time period between being tested for chlamydia and receiving test result and treatment"
"A facility to enable high-quality, time-efficient evaluations of diagnostics for STIs"
"Testing and treating STIs in hard to reach populations"
Year(s) Of Engagement Activity 2015
 
Description BASHH 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 4 abstracts accepted
3 Posters
1 Oral presentation

Atlas Genetics had a stand.
Year(s) Of Engagement Activity 2016
URL https://www.bashh.org/events/annual-conference/annual-conference-2016/
 
Description BASHH Diagnostics Course 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Tariq Sadiq gave an oral presentation, and a review of the meeting was published: http://journals.sagepub.com/doi/abs/10.1177/0956462416628782?ai=1gvoi&mi=3ricys?=R
Year(s) Of Engagement Activity 2015
 
Description BASHH Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact -
Year(s) Of Engagement Activity 2011
 
Description BSIG 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Works with BASHH to provide educational and research support in the field of sexually transmitted infections
Year(s) Of Engagement Activity 2016
URL https://www.bashh.org/bashh-groups/special-interest-groups/
 
Description Beckton Dickinson 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact advisory board membership for BD provision for UK sexual heath UK (by invititation)
Year(s) Of Engagement Activity 2017
 
Description BioSensing Knowledge Tranfer Network 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact -
Year(s) Of Engagement Activity 2011
 
Description Biosensing Knowledge Transfer Network 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact -
Year(s) Of Engagement Activity 2011
 
Description BiosensingKTN 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Poster Presentation
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact -
Year(s) Of Engagement Activity 2011
 
Description Biosensors 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact -
Year(s) Of Engagement Activity 2014
 
Description Biosensors 2014 (2) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact -
Year(s) Of Engagement Activity 2014
 
Description Biosure (UK) ltd 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact please add
Year(s) Of Engagement Activity 2017
 
Description Brunel Diagnostics for the Developing World symposium 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentations:
"Antimicrobial resistance and point of care tests for sexually transmitted infections"
"Development of a tool for assessment of the impact of introduction of point-of-care tests for STIs"
Year(s) Of Engagement Activity 2015
 
Description Carbohagen 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Poster Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact -
Year(s) Of Engagement Activity 2012
 
Description Carbonhagen 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact -
Year(s) Of Engagement Activity 2012
 
Description ChiNano 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact -
Year(s) Of Engagement Activity 2011
 
Description ChiNano 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact -
Year(s) Of Engagement Activity 2011
 
Description Chlamydia Serology Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact To understand the role of Chlamydia serology assays
Year(s) Of Engagement Activity 2016
 
Description Click Diagnostics-USA 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact possible future collaborations were discussed
Year(s) Of Engagement Activity 2018
 
Description Diagnostics in the Developing World 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Diagnostics in the developing world conference co-sponsored by eSTI2.
Balachandran W, "Low Cost Molecular Diagnostics for the Developing World", Diagnostics and the Developing World Conference, London, 23-25 January 2017 - presentation

Enabling Rapid Personalised Medicine and Real-Time Antibiotic Resistance Surveillance for Global and Advanced Health Systems, Dr.Tariq Sadiq,St. George's University of London
Year(s) Of Engagement Activity 2017
 
Description ECCMID Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact -
Year(s) Of Engagement Activity 2014
 
Description ESCR 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 2 Posters

Atlas Genetics had a stand and Precise Study brochures were distributed
Year(s) Of Engagement Activity 2016
 
Description EU Observer 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact -
Year(s) Of Engagement Activity 2012
 
Description European Lab Automation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact -
Year(s) Of Engagement Activity 2011
 
Description European Lab Automation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact -
Year(s) Of Engagement Activity 2011
 
Description European Lab Automation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Poster Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact -
Year(s) Of Engagement Activity 2011
 
Description Federation of Infection Societies Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact -
Year(s) Of Engagement Activity 2014
 
Description GRASP collaborators meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on diagnostics for NG and AMR
Year(s) Of Engagement Activity 2016
 
Description GUMNet Steering Group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Health professionals
Results and Impact -
Year(s) Of Engagement Activity 2011
 
Description GlaxoSmithKline plc 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact GSK is running a clinical trial III study in patients with UUTI and asked us to participate as a trial site. unfortunately because the closure of the St George's GUM clinic we are unable to participate this study.
Year(s) Of Engagement Activity 2018
 
Description Global Good Fund 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Third sector organisations
Results and Impact discussing potential colloboration activities and research studies with Global Good and QuantumDx
Year(s) Of Engagement Activity 2018
 
Description Health Protection Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact -
Year(s) Of Engagement Activity 2011
 
Description ISSTDR 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact STI & AIDS World Congress 2013
July 14 to 17, 201
Hofburg Congress Center, Vienna.
What are young people's perceptions of using electronic self-tests for STIs linked to mobile technology for diagnosis and care (eSTI2)?
Fuller, SS; Aicken C; Sutcliffe LJ; Estcourt CS; Gkatzidou V; Hone K; Sonnenberg, P; Oakeshott, P; Sadiq, ST; Shahmanesh, M.

-
Year(s) Of Engagement Activity 2013
URL http://sti.bmj.com/content/89/Suppl_1/A69.3.abstract
 
Description ISSTDR 2015 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact eSTI2 undertook 7 poster presentations and 2 oral presentation

The e-clinical pathway presented to the conference was accepted as cutting edge in feedback from peers.
Year(s) Of Engagement Activity 2015
 
Description IUSTI Malta 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact -
Year(s) Of Engagement Activity 2014
 
Description IUSTI World Congress 2015, Sitges 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation
Year(s) Of Engagement Activity 2015,2016
 
Description IUSTI world congress 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Poster Presentation
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact -
Year(s) Of Engagement Activity 2012
 
Description IUSTI world congress 2016, Marrakesh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 2 Oral presentations
Year(s) Of Engagement Activity 2015,2016
 
Description Imperial College of London 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Potential collaboration with Professor Pau Heath to use ADREU laboratories to promote vaccine work on Group B strep
Year(s) Of Engagement Activity 2017
 
Description Innovate 2015 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Brunel presented the PoC CT platform (Felix)

Precise Study brochures handed out

Significant interest in device especially speed of assay
Year(s) Of Engagement Activity 2015
 
Description Institute for Infection and immunity Away Day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Presentation on ADREU diagnostics evaluation service
Year(s) Of Engagement Activity 2016
 
Description International Society for STD Research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact -
Year(s) Of Engagement Activity 2011
 
Description Jenner Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation Enabling rapid personalised medicine and realtime AMR surveillance for Global Advanced health systems
Year(s) Of Engagement Activity 2016
 
Description Lab on Chip Congress 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Poster Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact -
Year(s) Of Engagement Activity 2011
 
Description Lab on a Chip 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Poster Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact -
Year(s) Of Engagement Activity 2011
 
Description Lab on a Chip World Congress 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact -
Year(s) Of Engagement Activity 2011
 
Description London School of Hygiene and Tropical Medicine 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Industry/Business
Results and Impact please add
Year(s) Of Engagement Activity 2017
 
Description Maddison 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact This was a preliminary meeting, prior to discussion about moving forward a diagnostic evaluation of a new technology for detection and AMR
Year(s) Of Engagement Activity 2017
 
Description Med Tech 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact -
Year(s) Of Engagement Activity 2012
 
Description Med-Tech 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact -
Year(s) Of Engagement Activity 2012
 
Description Meeting of the ECDC STI and HIV Networks, Bratislava 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Meeting on Rapid Point of Care Diagnostics for Sexually Transmitted Infections and Antimicrobial Resistance. Dissemination of Research and creation of scientific collaboration. Future collaborations planned
Year(s) Of Engagement Activity 2016
 
Description Micro and Nano Flows 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact -
Year(s) Of Engagement Activity 2014
 
Description MicroTas 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Poster Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact -
Year(s) Of Engagement Activity 2013
 
Description Mologic 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Early Stage Diagnostic Evaluation: Mologic are are interested in obtaining clinical samples for assay development
Year(s) Of Engagement Activity 2017
 
Description NanoKTN 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Supporters
Results and Impact -
Year(s) Of Engagement Activity 2013
 
Description Nanopore Community Meeting 2016. The Metropolitan Pavilion, New York 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact An opportunity to present our work at the nanopore meeting
Year(s) Of Engagement Activity 2016
URL https://nanoporetech.com/events/ncm16
 
Description Network Enterprise Europe 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact -
Year(s) Of Engagement Activity 2010
 
Description Orasure 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact please add
Year(s) Of Engagement Activity 2017
 
Description PHE National Infection Service Emerging Infectious Diseases 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Oral presentation of work conducted by SGUL's Applied Diagnostic Research and Evaluation Unit (ADREU), including Precise and eSTI2
Year(s) Of Engagement Activity 2016
 
Description Phillips 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact This was a consultatation for the potential involvement of ADREU into working with Phillips AMR predictor database.
Year(s) Of Engagement Activity 2017
 
Description Point-of-care test symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Point-of-care testing symposium organised by Public Health England (result of the Innovate UK POCTiC web-tool SBRI grant). Tariq Sadiq gave a talk entitled "Antimicrobial resistance and point of care tests for sexually transmitted infections"
Year(s) Of Engagement Activity 2015
 
Description Presentation at the Bacterial Special Interest Group Scientific Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This was a presentation on M. genitalium, incorporating aspects of work done, funded by both grants.
Year(s) Of Engagement Activity 2018
 
Description Press Release 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Multiple media publications and enquiries about the research

Multiple newspaper and magazine articles all over the world describing the eSTI2 programme
Year(s) Of Engagement Activity 2010
 
Description QuantumDX 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Future possible collaboration opportunities have been discussed.
Year(s) Of Engagement Activity 2018
 
Description Radio Interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact -
Year(s) Of Engagement Activity 2011
 
Description Research, Innovate, Grow conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Presentation of the eSTI2 diagnostic evaluation capabilities

Significant interest in the service that eSTI2 are proposing to provide
Year(s) Of Engagement Activity 2015
 
Description Roche 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Potential research collaboration using Roche technology for AMR prediction
Year(s) Of Engagement Activity 2018
 
Description Royal Berkshire NHS Foundation Trust 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact discuss opportunities for evaluations and CLRN approved studies for diagnostic medical device trials and research studies - stregthening potential collaboarations for future studies
Year(s) Of Engagement Activity 2018
 
Description Rutherford Appleton Laboratory 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact -
Year(s) Of Engagement Activity 2014
 
Description SBRI2 Press release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact On the launch of our project with Atlas Genetics Ltd., funded by Innovate UK (e.g. SBRI2), Atlas, Aquarius Population Health and SGUL press office collaboratively created a press release about the work.
Year(s) Of Engagement Activity 2017
URL https://www.sgul.ac.uk/news/news-archive/new-rapid-sexual-infection-test-set-to-transform-nation-s-h...
 
Description SELECTBIO - India 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Balachandran W, "Sequentially Linked Integrated Cassette for Molecular Diagnostics-SLIC MDx", Microfluidics, Liquid Handling & Lab-on-a-Chip Conference, organised by SELECTBIO-India, Mumbai, 18-19 January 2017 - Keynote Presentation
Year(s) Of Engagement Activity 2016
 
Description SELECTBIO - Singapore 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Balachandran W, "Sequentially Linked Integrated Cassette for Molecular Diagnostics - SLIC DX", Lab-on-a-Chip Asia Conference, organised by SELECTBIO-Singapore, 5-6 December 2016 - Invited presentation
Year(s) Of Engagement Activity 2016
 
Description SWAGNET 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Health professionals
Results and Impact -
Year(s) Of Engagement Activity 2011
 
Description Sample Prep East 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact -
Year(s) Of Engagement Activity 2013
 
Description SawDX 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact request for potential area for collaboration
Year(s) Of Engagement Activity 2018
 
Description Sensors in Medicine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact -
Year(s) Of Engagement Activity 2014
 
Description Sexual Planning for London 2012 Olympic Games 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Policymakers/parliamentarians
Results and Impact -
Year(s) Of Engagement Activity 2011
 
Description SlipChip Corporation-USA 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact consultancy service- expert opinion, clinical experiences in connection with the provision of point of care services in medical care or clinical setting.
Year(s) Of Engagement Activity 2017
 
Description St Georges Research Day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact 4 Posters
Year(s) Of Engagement Activity 2016
 
Description Tosoh-Japan 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Late Stage Diagnostic Evaluation- for CE marking of their test platform. Initial discussion about a protocol and the technology itself. There is potential for moving this forward.
Year(s) Of Engagement Activity 2017
 
Description UCL Festival for Digital Health 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Presentation by Aicken C, Sonnenberg P, Estcourt C, Johnson A, Mercer C. Who uses the internet for sexual healthcare? Evidence from a nationally-representative survey of the British population.
UCL Festival for Digital Health, London, UK, 23-25th June 2014.
Year(s) Of Engagement Activity 2014
 
Description UCL Life Long Health Domain Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation on Online STI / HIV management
Year(s) Of Engagement Activity 2016
 
Description UK-India Workshop on Tackling the Emergence of Antimicrobial Resistance: Increasing Awareness and Facilitating Research Networks. 7-10 November 2016 Chandigarh, India 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact This was a highly successful workshop addressing the challenges of antimicrobial resistance internationally
Year(s) Of Engagement Activity 2016
 
Description UKCRC Syposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact -
Year(s) Of Engagement Activity 2013
 
Description iboss 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Industry/Business
Results and Impact Discussion for the potential collaboration to work on surveillance systems in Ecuador. Remaining active in potential future discussions.
Year(s) Of Engagement Activity 2017