Developmental pathways into adolescent substance abuse: neurophysiologic, genetic and environmental determinants

Lead Research Organisation: King's College London
Department Name: Child and Adolescent Psychiatry

Abstract

In this study we want to learn to better understand the interplay of genes, brain function and environmental influences and how they result in the development of adolescent abuse of alcohol, nicotine and cannabis. To this end we will examine 2000 14 year old participants of the IMAGEN sample which have been characterised using functional neuroimaging analysis of behavioural processes like reward dependence, impulsivity and emotional reactivity which are known to be relevant for the development of adolescent substance abuse. In addition, to extensive behavioural and clinical assessments, a genome-wide analysis has been carried out in these children. We now propose to extend the IMAGEN study in order to observe the development of substance use patterns in the context of moderating environmental factors, such as exposure to alcohol, nicotine or drugs as well as psychosocial stress. We aim to identify and to characterise a multidimensional risk profile of genes, brain function and environmental influences which helps us to predict risk for early onset substance abuse, including binge drinking, smoking or cannabis abuse. We will test our model in a second large cohort of 10000 adolescents, the ALSPAC cohort. Our final goal is to contribute to the development of specific early interventions in carriers of the risk profile to reduce the incidence of adolescent substance abuse.

Technical Summary

Early onset and progression to adolescent substance abuse is genetically influenced and has been consistently shown to be associated with later risk for substance use disorders. Behavioural constructs, such as impulsivity, sensation seeking and harm avoidance are thought to be involved in mediation of increased genetic risk for substance abuse. However, neurophysiologic processes which mediate genetic risk might not be reflected in behavioural phenotypes due to compensatory factors, but may instead be revealed by functional neuroimaging. Understanding how neurophysiological processes mediate genetic risk but also how moderating environmental factors alter risk or resilience for adolescent substance abuse may identify neurobehavioural determinants which prove crucial for the development of targeted interventions. We propose to identify and to characterize a multidimensional risk profile of determinants for adolescent substance abuse, including abuse of alcohol, nicotine and cannabis based on longitudinal observations of subjects characterized in the IMAGEN study, the first cross sectional, multi-centre functional and structural genetic-neuroimaging study of a cohort of 2000+ 14 year old adolescents which investigates the neurophysiologic and genetic basis of individual differences in behaviours relevant for the development of substance abuse, including reward response, impulsivity and emotional reactivity. To this end we will complement the existing IMAGEN study by adding repeated longitudinal assessments of substance use patterns, behavioural development as well as psychosocial stress and exposure to licit and illicit substances covering adolescence up to the age of 18 years. Longitudinal analysis of the IMAGEN dataset will allow a systematic, genome-wide analysis of gene x environment interactions and their neurobehavioural mediation resulting in adolescent alcohol, nicotine and cannabis abuse. We will replicate our findings in the Avon Longitudinal Study of Parents and Children (ALSPAC), a regional birth cohort of 10.000 individuals. Integrated analysis of the IMAGEN and the ALSPAC study will allow us to better understand the complex interplay of genetic, developmental and environmental factors leading to adolescent substance abuse and relate them to neurobehavioural mechanisms as measured in neuroimaging analyses.

Publications

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publication icon
Burt KB (2016) Structural brain correlates of adolescent resilience. in Journal of child psychology and psychiatry, and allied disciplines

 
Description Scientific advisory committees of the Leibniz Institute for Neurobiology and the IMI AETIONOMY
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
 
Description ERC advanced grant 'STRATIFY'
Amount € 3,490,000 (EUR)
Funding ID 695313 
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 10/2016 
End 09/2021
 
Description FORMAS
Amount 500,000 kr (SEK)
Organisation Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS) 
Sector Private
Country Sweden
Start 06/2012 
End 05/2018
 
Description Horizon 2020
Amount € 4,000,000 (EUR)
Organisation JPND Research 
Sector Academic/University
Country Global
Start 07/2016 
End 06/2019
 
Description IMAGEMEND
Amount € 6,000,000 (EUR)
Funding ID 602450 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 10/2013 
End 09/2017
 
Description IMAGEN pathways (ERANID)
Amount £193,162 (GBP)
Organisation Government of Catalonia 
Department Department of Health
Sector Public
Country Spain
Start 01/2017 
End 12/2019
 
Description Innovative Medicine Initiative
Amount £500,000 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start  
 
Description MATRICS
Amount € 4,500,000 (EUR)
Funding ID 603016 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2014 
End 03/2017
 
Description NIH-BD2K (Big Data to Knowledge) U54 - ENIGMA
Amount $290,047 (USD)
Organisation University of Southern California 
Department Enigma Center
Sector Academic/University
Country United States
Start 09/2014 
End 08/2018
 
Description ROAMER
Amount € 103,844 (EUR)
Funding ID 282586 
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 01/2011 
End 09/2014
 
Description SysAlc01ZX1311A
Amount € 594,776 (EUR)
Organisation German Federal Ministry of Education and Research 
Sector Public
Country Germany
Start 01/2014 
End 12/2018
 
Title IMAGEN Database 
Description The aim of this project is to identify the neurobiological and genetic basis of neurobiological and behavioural traits and to assess their relevance for mental disorder. We have created a database that brings together data collected of over 2000 adoelscents (aged 14 and 16 years) on three types of information: neuroimages, psychometric/ neuropsychological test battery, and genetics. An additional follow-up assessment of our cohort at age 19 years is in progress. From the production devices (either MR acquisistion scanners, realtime companion data files or web forms) the data is anonymised and a further crypted transfer maintains the integrity of the databank. The database aims to make data available in a sustained and secure manner, offer ways of searching specific data, and enable the easy updating of the data repository, either for curation or storing results obtained from processing tools. 
Type Of Material Biological samples 
Year Produced 2011 
Provided To Others? Yes  
Impact Stein JL, Medland SE, Vasquez AA, Hibar DP, Senstad RE, Winkler AM, Toro R, Appel K, Bartecek R, Bergmann Ø, Bernard M, Brown AA, Canon D, Chakravarty M, Christoforou A, Domin M, Grimm O, Hollinshead M, Holmes AJ, Homuth G, Hottenga JJ, Lopez LM, Hansell NK, Hwang KS, Laje SKG, Lee PH, Liu X, Loth E, Lourdusamy A, Maniega SM, Mattingsdal M, Nho K, Nugent AC, O'Brien C, Papmeyer M, Pütz B, Rijpkema M, Risacher SL, Rose EJ, Shen L, Sprooten E, Strengman E, Teumer A, van Eijk K, van Erp TGM, van Tol MJ, Wittfeld K, Wolf C, Woudstra S, Aleman A, Alhusaini S, Almasy L, Binder EB, Brohawn D, Cantor RM, Carless MA, Corvin A, Czisch M, Curran JE, Davies G, Delanty N, Depondt C, Duggirala R, Dyer TD, Erk S, Fagerness J, Fox PT, Freimer NB, Gill M, Göring HHH, Höhn D, Hosten N, Johnson MP, Kasperaviciute D, Kent Jr. JW, Kochunov P, Lancaster JL, Lawrie SM, Liewald DC, Mandl R, Matarin M, Mattheisen M, Meisenzahl E, Melle I, Moses EK, Mühleisen TW, Nauck M, Nöthen MM, Olvera RL, Pike GB, Puls R, Reinvang I, Rentería ME, Rietschel M, Roffman J, Royle NA, Rujescu D, Savitz J, Schnack HG, Schnell K, Steen VM, Hernández MCV, van den Heuvel M, van der Wee NJ, van Haren NEM, Veltman JA, Völzke H, Walter H, Agartz I, Boomsma DI, Cavalleri GL, Dale AM, Djurovic S, Drevets WC, Hagoort P, Hall J, Jack Jr. CR, Foroud TM, Le Hellard S, Macciardi F, Montgomery GW, Poline JB, Porteous DJ, Sisodiya SM, Starr JM, Sussmann J, Toga AW, Veltman DJ, Weiner MW, the Alzheimer's Disease Neuroimaging Initiative, IMAGEN Consortium, Saguenay Youth Study Group, Bis JC, Ikram MA, Smith AV, Tzourio C, Vernooij MW, Launer LJ, DeCarli C, Seshadri S, Andreassen OS, Apostolova LG, Bastin ME, Blangero J, Brunner HG, Buckner RL, Cichon S, Coppola G, de Zubicaray GI, Deary IJ, Donohoe G, de Geus EJC, Espeseth T, Fernández G, Glahn DC, Grabe HJ, Jenkinson M, Kahn RS, McDonald C, McIntosh AM, McMahon MJ, McMahon KL, Meyer-Lindenberg A, Morris DW, Müller-Myhsok B, Nichols TE, Ophoff RA, Tomas Paus, Zdenka Pausova, Brenda W. Penninx, Hilleke E. Hulshoff Pol, Steven G. Potkin, Sämann PG, Saykin AJ, Schumann G, Smoller JW, Wardlaw JM, Wright MJ, Franke B, Martin NG, Thompson PM, for the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium Common genetic polymorphisms contribute to the variation in human hippocampal and intracranial volume. Identification of common variants associated with human hippocampal and intracranial volumes. Nature Genetics, 44(5):552-561. 
 
Description IMAGEN 
Organisation Alternative Energies and Atomic Energy Commission (CEA)
Country France 
Sector Public 
PI Contribution Coordinator The IMAGEN study is a longitudinal, multi-centre functional and structural genetic-neuroimaging study of a cohort of 2000+ adolescents, studying the neurobiological basis of individual differences in brain responses to reward, punishment and emotional cues at 14, 16 and 19 years. It involves 8 recruitment centres in four European countries.
Collaborator Contribution See above
Impact see publication list
Start Year 2007
 
Description IMAGEN 
Organisation European Commission
Country European Union (EU) 
Sector Public 
PI Contribution Follow-up characterisation of participants
Collaborator Contribution Provision of samples and data, data analysis.
Impact Risk Taking and the Adolescent Reward System: A Potential Common Link to Substance Abuse. Schneider S, Peters J, Bromberg U, Brassen S, Miedl SF, Banaschewski T, Barker GJ, Conrod P, Flor H, Garavan H, Heinz A, Ittermann B, Lathrop M, Loth E, Mann K, Martinot JL, Nees F, Paus T, Rietschel M, Robbins TW, Smolka MN, Spanagel R, Ströhle A, Struve M, Schumann G, Büchel C; the IMAGEN Consortium. Am J Psychiatry. 2011 Sep 28. [Epub ahead of print] PMID: 21955931 [PubMed - as supplied by publisher] Manual dexterity correlating with right lobule VI volume in right-handed 14-year-olds. Kühn S, Romanowski A, Schilling C, Banaschewski T, Barbot A, Barker GJ, Brühl R, Büchel C, Conrod PJ, Czech K, Dalley JW, Flor H, Garavan H, Häke I, Ittermann B, Ivanov N, Mann K, Lathrop M, Loth E, Lüdemann K, Mallik C, Martinot JL, Palafox C, Poline JB, Reuter J, Rietschel M, Robbins TW, Smolka MN, Nees F, Walaszek B, Schumann G, Heinz A, Gallinat J; the IMAGEN consortium. Neuroimage. 2011 Sep 8. [Epub ahead of print] PMID: 21925277 [PubMed - as supplied by publisher] Creating probabilistic maps of the face network in the adolescent brain: A multicentre functional MRI study. Tahmasebi AM, Artiges E, Banaschewski T, Barker GJ, Bruehl R, Büchel C, Conrod PJ, Flor H, Garavan H, Gallinat J, Heinz A, Ittermann B, Loth E, Mareckova K, Martinot JL, Poline JB, Rietschel M, Smolka MN, Ströhle A, Schumann G, Paus T; The IMAGEN Consortium. Hum Brain Mapp. 2011 Mar 17. doi: 10.1002/hbm.21261. [Epub ahead of print] PMID: 21416563 [PubMed - as supplied by publisher] Lower ventral striatal activation during reward anticipation in adolescent smokers. Peters J, Bromberg U, Schneider S, Brassen S, Menz M, Banaschewski T, Conrod PJ, Flor H, Gallinat J, Garavan H, Heinz A, Itterman B, Lathrop M, Martinot JL, Paus T, Poline JB, Robbins TW, Rietschel M, Smolka M, Ströhle A, Struve M, Loth E, Schumann G, Büchel C; IMAGEN Consortium. Am J Psychiatry. 2011 May;168(5):540-9. Epub 2011 Mar 1. PMID: 21362742 [PubMed - indexed for MEDLINE] Boys do it the right way: sex-dependent amygdala lateralization during face processing in adolescents. Schneider S, Peters J, Bromberg U, Brassen S, Menz MM, Miedl SF, Loth E, Banaschewski T, Barbot A, Barker G, Conrod PJ, Dalley JW, Flor H, Gallinat J, Garavan H, Heinz A, Itterman B, Mallik C, Mann K, Artiges E, Paus T, Poline JB, Rietschel M, Reed L, Smolka MN, Spanagel R, Speiser C, Ströhle A, Struve M, Schumann G, Büchel C; IMAGEN consortium. Neuroimage. 2011 Jun 1;56(3):1847-53. Epub 2011 Feb 22. PMID: 21316467 [PubMed - indexed for MEDLINE]
Start Year 2009
 
Description IMAGEN 
Organisation Heidelberg University
Country Germany 
Sector Academic/University 
PI Contribution Coordinator The IMAGEN study is a longitudinal, multi-centre functional and structural genetic-neuroimaging study of a cohort of 2000+ adolescents, studying the neurobiological basis of individual differences in brain responses to reward, punishment and emotional cues at 14, 16 and 19 years. It involves 8 recruitment centres in four European countries.
Collaborator Contribution See above
Impact see publication list
Start Year 2007
 
Description IMAGEN 
Organisation Humboldt University of Berlin
Country Germany 
Sector Academic/University 
PI Contribution Coordinator The IMAGEN study is a longitudinal, multi-centre functional and structural genetic-neuroimaging study of a cohort of 2000+ adolescents, studying the neurobiological basis of individual differences in brain responses to reward, punishment and emotional cues at 14, 16 and 19 years. It involves 8 recruitment centres in four European countries.
Collaborator Contribution See above
Impact see publication list
Start Year 2007
 
Description IMAGEN 
Organisation National Institute of Health and Medical Research (INSERM)
Country France 
Sector Academic/University 
PI Contribution Coordinator The IMAGEN study is a longitudinal, multi-centre functional and structural genetic-neuroimaging study of a cohort of 2000+ adolescents, studying the neurobiological basis of individual differences in brain responses to reward, punishment and emotional cues at 14, 16 and 19 years. It involves 8 recruitment centres in four European countries.
Collaborator Contribution See above
Impact see publication list
Start Year 2007
 
Description IMAGEN 
Organisation Technical University of Dresden
Country Germany 
Sector Academic/University 
PI Contribution Coordinator The IMAGEN study is a longitudinal, multi-centre functional and structural genetic-neuroimaging study of a cohort of 2000+ adolescents, studying the neurobiological basis of individual differences in brain responses to reward, punishment and emotional cues at 14, 16 and 19 years. It involves 8 recruitment centres in four European countries.
Collaborator Contribution See above
Impact see publication list
Start Year 2007
 
Description IMAGEN 
Organisation University Medical Center Hamburg-Eppendorf
Country Germany 
Sector Hospitals 
PI Contribution Coordinator The IMAGEN study is a longitudinal, multi-centre functional and structural genetic-neuroimaging study of a cohort of 2000+ adolescents, studying the neurobiological basis of individual differences in brain responses to reward, punishment and emotional cues at 14, 16 and 19 years. It involves 8 recruitment centres in four European countries.
Collaborator Contribution See above
Impact see publication list
Start Year 2007
 
Description IMAGEN 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Coordinator The IMAGEN study is a longitudinal, multi-centre functional and structural genetic-neuroimaging study of a cohort of 2000+ adolescents, studying the neurobiological basis of individual differences in brain responses to reward, punishment and emotional cues at 14, 16 and 19 years. It involves 8 recruitment centres in four European countries.
Collaborator Contribution See above
Impact see publication list
Start Year 2007
 
Description IMAGEN 
Organisation University of Dublin
Country Ireland 
Sector Academic/University 
PI Contribution Coordinator The IMAGEN study is a longitudinal, multi-centre functional and structural genetic-neuroimaging study of a cohort of 2000+ adolescents, studying the neurobiological basis of individual differences in brain responses to reward, punishment and emotional cues at 14, 16 and 19 years. It involves 8 recruitment centres in four European countries.
Collaborator Contribution See above
Impact see publication list
Start Year 2007
 
Description IMAGEN 
Organisation University of Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Coordinator The IMAGEN study is a longitudinal, multi-centre functional and structural genetic-neuroimaging study of a cohort of 2000+ adolescents, studying the neurobiological basis of individual differences in brain responses to reward, punishment and emotional cues at 14, 16 and 19 years. It involves 8 recruitment centres in four European countries.
Collaborator Contribution See above
Impact see publication list
Start Year 2007
 
Description KCL-Fudan PONS Early Careers Award 
Organisation Fudan University
Country China 
Sector Academic/University 
PI Contribution KCL (PONS) provides Fudan insight and developments in precision medicine.
Collaborator Contribution Fudan provides KCL (PONS) insight and developments in biostatisics.
Impact N/A - collaboration is new.
Start Year 2020
 
Description MRC-ICMR Newton call 
Organisation Indian Council of Medical Research (ICMR)
Country India 
Sector Public 
PI Contribution The joint MRC-ICMR Newton call aims at promoting research collaboration between Indian and UK investigators in the area of substance misuse and mental health research. The work could build on existing partnerships/networks/cohorts. The call specifically highlights two study areas, longitudinal studies and clinical studies. While the expertise of our consortium is in longitudinal studies, we will also be able to contribute to aims of clinical studies. Funding for this call will be provided jointly by the MRC and the ICMR. The overall budget of the MRC is £ 2 million for an anticipated 2-3 funded projects for 2-3 years.
Collaborator Contribution (1) Our project will investigate the effect of environmental factors, and candidate genetic and epigenetic variants on behaviour, psychopathology and brain function associated with externalizing symptoms and addictive behavior from early childhood to young adults. While focusing on addictions and mental health, our behavioural and clinical characterisations will be sufficiently broad to allow investigations of a wider scope of behaviours, and their relation to physical symptoms.
Impact n/a
Start Year 2014
 
Description MRC-ICMR Newton call 
Organisation King's College London
Department MRC Social Genetic and Developmental Psychiatry Centre (SDGP)
Country United Kingdom 
Sector Academic/University 
PI Contribution The joint MRC-ICMR Newton call aims at promoting research collaboration between Indian and UK investigators in the area of substance misuse and mental health research. The work could build on existing partnerships/networks/cohorts. The call specifically highlights two study areas, longitudinal studies and clinical studies. While the expertise of our consortium is in longitudinal studies, we will also be able to contribute to aims of clinical studies. Funding for this call will be provided jointly by the MRC and the ICMR. The overall budget of the MRC is £ 2 million for an anticipated 2-3 funded projects for 2-3 years.
Collaborator Contribution (1) Our project will investigate the effect of environmental factors, and candidate genetic and epigenetic variants on behaviour, psychopathology and brain function associated with externalizing symptoms and addictive behavior from early childhood to young adults. While focusing on addictions and mental health, our behavioural and clinical characterisations will be sufficiently broad to allow investigations of a wider scope of behaviours, and their relation to physical symptoms.
Impact n/a
Start Year 2014
 
Description Workshop: Remote urbanisation sensing and mental health 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Train satellite data analysts and develop machine learning methods for image classification of built-up land cover established to include relevant rural parameters that relate to mental health.
Year(s) Of Engagement Activity 2017
 
Description 19th International Neuroscience Winter Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Presentation talk of research portfolio of projects related to mental health and brain development
Year(s) Of Engagement Activity 2017
 
Description 2016 Alcohol and The Nervous System 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Gordon Research Conference
Year(s) Of Engagement Activity 2016
 
Description 23th Chinese Congress of Radiology (CCR) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Integration, Innovation and Evolution
Year(s) Of Engagement Activity 2016
 
Description AETIONOMY General Assembly 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Key Note Speaker, "Developing imaging predictors and neurobehavioural phenotypes for externalising disorders."
Year(s) Of Engagement Activity 2016
 
Description AETIONOMY IV GENERAL ASSEMBLY 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact AETIONOMY - Steering Committee, General Assembly & ESAB Meeting
Year(s) Of Engagement Activity 2017
 
Description Biostatistics Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Munich, 2016
Year(s) Of Engagement Activity Pre-2006
 
Description British Association of Psychopharmacology Summer meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact British Association of Psychopharmacology Summer meeting
Year(s) Of Engagement Activity 2017
 
Description Consortium on Vulnerability to Externalising Disorders and Addiction- study methods and application 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The methods and research goals of the cVEDA study were presented to colleagues involved in similar research studies focusing on precision medicine and international cohorts.
Year(s) Of Engagement Activity 2016
 
Description Educational Day in India 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact The cVEDA consortium has agreed to invest in academic & research training for young scholars in psychiatry and related fields. Under this initiative we are organising a half-day educational programme conducted at NIMHANS, Bangalore, from 11:00 am- 4:00 pm on March 11th. The theme was 'basic concepts in genetics and imaging research and their applications in the behavioural sciences'. Postgraduate students in Psychiatry, molecular biology, radiology and neurology participated in this programme. We invited distinguished scientists and academicians from the US, Europe, and the UK to speak about psychiatry, imaging and genetics . As MD students in India typically get little exposure to advanced research methods in imaging and genetics, this was a unique opportunity for young aspiring postgraduate students to listen to experts in the field.
Year(s) Of Engagement Activity 2017
 
Description Expert panel, Addiction Research Strategy, Medical Research Council (MRC) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Expert panel, Addiction Research Strategy, Medical Research Council (MRC).
Year(s) Of Engagement Activity 2009
 
Description Expert review panel, Neuroscience Research at Imperial College 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Expert review panel, "Neuroscience Research at Imperial College"
Year(s) Of Engagement Activity 2011
 
Description Global Imaging Genetics in Adolescents - Consortium Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact Annual GIGA Consortium Meeting
Year(s) Of Engagement Activity 2017
 
Description HBP Meetings in Aachen/Juelich 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact Collaboration meetings and presentation in "Precision medicine and global mental health" related to HBP
Year(s) Of Engagement Activity 2017
 
Description IMAGEN Annual Consortium Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact Annual Recruitment progress meeting of the IMAGEN Consortium
Year(s) Of Engagement Activity 2017
 
Description International conference for machine learning (ICML) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Workshop on the use of machine leaning techniques to address big data analysis.
Year(s) Of Engagement Activity 2017
 
Description Invited talk for National Institute of Developmental Psychiatry/High Risk Cohort Study on population neuroscience - 2nd edition (UFRGS/USP/UNIFESP- Sao Paolo, Brazil) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 100+ international researchers and students attended this conference to learn about population neuroscience as well as how to do collaborative research both nationally and internationally. Discussion about cVEDA and building international cohorts led to future ideas of collaboration, and how to conduct imaging genetic studies on adolescents.
Year(s) Of Engagement Activity 2016
 
Description Panel, Winter Conference on Brain Research 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Neurobehavioral, Neuroimmune and Neuroendocrine Mechanisms of Ethanol Dependence
Year(s) Of Engagement Activity 2017
 
Description Plenary Lecture, "Int. Society for Biological Research in Alcoholism", Sapporo 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Conference, International Society for Biological Research in Alcoholism Sapporo
Year(s) Of Engagement Activity 2012
 
Description Plenary Lecture, German Society for Addiction Research, Berlin 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact German Society for Addiction Research
Year(s) Of Engagement Activity 2014
 
Description Plenary Lecture, Hungarian Society for Psychiatry 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Psychiatric Research in Europe: Policy and Practice
Year(s) Of Engagement Activity 2016
 
Description Plenary Lecture, Turkish Society for Psychiatry 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact International research networks in imaging genetics: developing imaging predictors and neurobehavioural phenotypes for externalising disorders
Meet the experst session- Conversation with young psychiatrists and residents who have interest in research...
Research perspectives and opportunities in Europe, US and other regions of the world
Year(s) Of Engagement Activity 2016
 
Description Presentation at National Institute on Drug Abuse (NIDA) at National Institute of Health (Washington DC, USA) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Gave a lecture on the goals of cVEDA and international collaborations, which sparked further discussion of collaborative research.
Year(s) Of Engagement Activity 2017
 
Description Scientific Advisory Board, Leibniz Institut für Neurobiologie, Magdeburg 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Leibniz Institute for Neurobiology
Year(s) Of Engagement Activity 2012,2016
 
Description WPA World Congress of Psychiatry 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact WPA Presentation
Year(s) Of Engagement Activity 2017
 
Description Workshop on China-Europe-India Network of Large Cohorts of Brain and Behavior 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact Large Cohorts of Brain and Behavior - gave presentation on rationale for large cohorts and shared data analyses highlighting the value of large cohorts for public health and society success
Year(s) Of Engagement Activity 2017