Developmental Clinical Studies:To determine the effectiveness of kisspeptin to induce oocyte maturation in IVF treatment

Lead Research Organisation: Imperial College London
Department Name: Dept of Medicine

Abstract

In vitro fertilisation (IVF) treatment is widely and successfully used to treat infertility, but can cause the life threatening condition called ovarian hyperstimulation syndrome (OHSS). Mild forms of OHSS occur in approximately 1/3rd of all IVF cycles, whilst moderate or severe OHSS occurs in up to 1/10th of IVF cycles. The cause is the use of a drug in IVF treatment which too powerfully stimulates the release of reproductive hormones. Kisspeptin is a hormone found naturally in men and women and it stimulates reproductive hormone secretion similarly to the stimulation which occurs in women with a normal menstrual cycle. In this study we will find out how effective kisspeptin is in patients requiring IVF treatment. Ultimately the aim of our research will be to determine if the use of kisspeptin in IVF treatment could prevent the potentially life threatening risk of OHSS in women with infertility who are otherwise healthy.

Technical Summary

Infertility affects one in six couples in the UK. In vitro fertilisation (IVF) treatment is now widely and successfully used to enable infertile couples to conceive. Approximately 45,000 cycles of IVF are performed in Britain each year. However, IVF treatment can result in the potentially life threatening condition, ovarian hyperstimulation syndrome (OHSS). Mild forms of OHSS occur in approximately 1 in 3 of all IVF cycles, whilst approximately 1 in 10 IVF cycles result in moderate or severe OHSS. The major cause of OHSS is the pharmacological use of human chorionic gonadotrophin (hCG) to stimulate oocyte maturation in current IVF protocols. The development of a more physiological stimulus for oocyte maturation should avoid this dangerous side effect and improve the safety and efficacy of IVF treatment. Kisspeptin is a hormone which stimulates reproductive hormone secretion in animals and is responsible for the endogenous luteinising hormone (LH) surge which results in ovulation. In keeping with this, exogenous administration of kisspeptin has been shown to induce ovulation in rats and sheep. Interestingly in rats primed with gonadotrophins, peripheral administration of kisspeptin promotes ovulation with equal efficacy to that following hCG administration. We have conducted the first studies of kisspeptin administration to humans, demonstrating that acute administration of kisspeptin potently stimulates reproductive hormone secretion in healthy men and women as well as in women with infertility due to hypothalamic amenorrhea. Importantly, we have demonstrated that healthy women with regular menstrual cycles are most sensitive to the effects of kisspeptin immediately prior to ovulation (i.e. in the pre-ovulatory phase). Recent evidence demonstrates that kisspeptin stimulates the release of a limited pool of endogenous gonadotrophin releasing hormone (GnRH) which results in the release of endogenous gonadotrophins. Therefore, the significant advantage of kisspeptin over current treatments is that its effects would depend on the sensitivity of an individual‘s hypothalamic-pituitary gonadal (HPG) axis to stimulation. This would result in a more physiological LH surge and oocyte maturation during IVF treatment, thereby improving safety and efficacy of IVF treatment. The aim of this study is to provide proof of concept that kisspeptin effectively induces oocyte maturation in IVF treatment.

Publications

10 25 50
 
Description Imperial College Healthcare Charity Research Fellowship
Amount £50,000 (GBP)
Funding ID RF15/1048 
Organisation Imperial College Healthcare NHS Trust 
Department Imperial College Healthcare NHS Charity
Sector Charity/Non Profit
Country United Kingdom
Start 11/2015 
End 06/2017
 
Description NIHR Career Development Fellowship
Amount £1,100,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 10/2010 
End 09/2015
 
Description Myovant Sciences Inc 
Organisation Myovant Sciences Inc
Country Australia 
Sector Private 
PI Contribution carrying out studies of a long acting kisspeptin analogue
Collaborator Contribution donation of the active compound at no cost
Impact current first into women study ongoing
Start Year 2016
 
Description 'Kisspeptin - hormonal regulator of puberty, reproduction and sexual emotion', Talk at Barts Endocrine Club, London November 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact 'Kisspeptin - hormonal regulator of puberty, reproduction and sexual emotion'
Talk at Barts Endocrine Club, London November 2016
Year(s) Of Engagement Activity 2016
 
Description 'We all remember our first kiss' - using hormones to treat infertility, Pint of Science Festival - my talk on infertility, May 2016 London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact 'We all remember our first kiss' - using hormones to treat infertility
Pint of Science Festival - my talk on infertility, May 2016 London
Year(s) Of Engagement Activity 2016
URL http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/eventssummary/event_20-5-2016-16-45-16
 
Description BBC filming, July 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact BBC filming
Year(s) Of Engagement Activity 2018
 
Description BBC news broadcast 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact BBC news broadcast (broadcast on BBC London News at 6.25am, 7am, 7.30am, 8am, 8.30am, 9am on 18/06/2013)



dissemination of information to the public
Year(s) Of Engagement Activity 2013
URL http://www.bbc.co.uk/news/uk-england-london-22953488
 
Description BBC website - research findings described 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact BBC news online covered a story regarding my research findings

diseemination f research findings to wide audience
Year(s) Of Engagement Activity 2013
URL http://www.bbc.co.uk/news/health-22935211
 
Description BRC open day at Imperial (2015) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Team members hosted stands and interacted with event attendees. Our research activities and potential impact/benefit to patients were highlighted.
Year(s) Of Engagement Activity 2015
 
Description BRC open day at Imperial (2016) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Clinical and non-clinical team members gave demonstrations and hosted exhibits featuring key aspects of our research and recent findings and relating them to everyday problems (including infertility and obesity).
Year(s) Of Engagement Activity 2016
 
Description Clinical studies with kisspeptin-9th International Congress of Neuroendocrinology (ICN2018) Toronto, July 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk- Clinical studies with kisspeptin- 9th International Congress of Neuroendocrinology (ICN2018) Toronto, July 2018
Year(s) Of Engagement Activity 2018
 
Description Diabetes and obesity lecture to Imperial College MRes students 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Talk focused on the modulation of brown fat activity as a potential obesity treatment.
Year(s) Of Engagement Activity 2015
 
Description Forging your clinical academic career, Association of Physicians of GB & Ireland meeting, Manchester April 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk- Forging your clinical academic career
Association of Physicians of GB & Ireland meeting, Manchester April 2018
Year(s) Of Engagement Activity 2018
 
Description Imperial Festival 2015 - Kisspeptin a safer fertility treatment 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The Imperial Festival celebrates the best science and arts on offer from Imperial staff, students and alumni. The annual programme of free activities is aimed at the general public, in particular family audiences, and includes talks, performances, experiments, lab tours, comedy, music, dance and more. The 2015 Imperial Festival attracted more than 15,000 visitors.
Kisspeptin a safer fertility treatment: Infertility is becoming increasingly common and the success rates of current therapies remains low. We describe our research into novel fertility treatments using a newly discovered reproductive hormone called kisspeptin and how we have used this in an IVF clinical trial. We also demonstrated how we conduct our clinical studies by taking blood samples and then centrifuging the samples.
Year(s) Of Engagement Activity 2015
URL http://www.imperial.ac.uk/be-inspired/festival/whats-on/activities/safer-fertility-treatment.php
 
Description Kisspeptin - a vital trigger for puberty, Great Ormond Street Hospital Paediatric Endocrine Seminar, Jan 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Great Ormond Street Hospital Paediatric Endocrine Seminar, Jan 2016
Year(s) Of Engagement Activity 2016
 
Description Kisspeptin and fertility, Erasmus Lectures on Endocrinology, Erasmus University, Rotterdam, The Netherlands, December 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Kisspeptin and fertility
Erasmus Lectures on Endocrinology
Erasmus University, Rotterdam, The Netherlands, December 2016
Year(s) Of Engagement Activity 2016
 
Description Kisspeptin and fertility, FOCUS meeting 2016 - International Annual Scientific Meeting of the Association for Clinical Biochemistry and Laboratory Medicine, Warwick, 21st April 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Kisspeptin and fertility
FOCUS meeting 2016 - International Annual Scientific Meeting of the Association for Clinical Biochemistry and Laboratory Medicine, Warwick, 21st April 2016
Year(s) Of Engagement Activity 2016
 
Description Kisspeptin and hypothalamic amenorrhea, COST meeting Budapest, 6-9th March 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact COST meeting Budapest, 6-9th March 2016
Year(s) Of Engagement Activity 2016
 
Description Management of Menopausal Hot Flashes: Hormonal and Nonhormonal Therapy, Oct 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Management of Menopausal Hot Flashes: Hormonal and Nonhormonal Therapy
Year(s) Of Engagement Activity 2018
 
Description Metabolic effects of kisspeptin 1st European Congress of Reproductive Endocrinology (EUCRE) Conference, Prato Italy, March 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Talk-Metabolic effects of kisspeptin
1st European Congress of Reproductive Endocrinology (EUCRE) Conference, Prato Italy, March 2018
Year(s) Of Engagement Activity 2018
 
Description Opportunities for clinical academic training, Clinical Update Meeting, Society for Endocrinology, 21st March 2016, Birmingham 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Clinical Update Meeting, Society for Endocrinology, 21st March 2016, Birmingham
Year(s) Of Engagement Activity 2016
 
Description Oral Communication at the American Endocrine Society Annual Conference, March 2015, San Diego 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral communication at the American Endocrine Society Annual Conference, March 2015, San Diego.
'Kisspeptin Signaling in the Amygdala Modulates Reproductive Hormone Secretion. AN Comninos, J Anastasovska, M Sahuri-Arisoylu, X Li, S Li, M Hu, CN Jayasena, MA Ghatei, SR Bloom, PM Matthews, KT O'Byrne, JD Bell, WS Dhillo.'
Awarded Oral Abstract Prize in Reproductive Science and Endocrine Society Prize for Best Oral Presentation in Reproductive Science
Year(s) Of Engagement Activity 2015
URL https://endo.confex.com/endo/2015endo/webprogram/Paper18810.html
 
Description Oral Communication at the American Endocrine Society Annual Conference, March 2015, San Diego 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral communication at the American Endocrine Society Annual Conference, March 2015, San Diego.
'Kisspeptin-54 safely and effectively triggers oocyte maturation during IVF treatment in women at high risk of
developing ovarian hyperstimulation syndrome (OHSS).
A Abbara, CN Jayasena, G Christopoulos, S Narayanaswamy, C Izzi-Engbeaya, GMK Nijher, AN Comninos, D Peters, A Buckley, R Ratnasabapathy, J Prague, MA Ghatei, SR Bloom, GH Trew, WS Dhillo.'
Year(s) Of Engagement Activity 2015
URL https://endo.confex.com/endo/2015endo/webprogram/Paper21219.html
 
Description Oral Communication at the European Society of Human Reproduction and Embryology Annual Meeting, 2015, Lisbon 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral communication at the European Society of Human Reproduction and Embryology Annual Meeting, 2015, Lisbon.
'Kisspeptin-54 safely and effectively triggers oocyte maturation during IVF treatment in women at high risk of
developing ovarian hyperstimulation syndrome (OHSS).
A Abbara, CN Jayasena, G Christopoulos, S Narayanaswamy, C Izzi-Engbeaya, GMK Nijher, AN Comninos, D Peters, A Buckley, R Ratnasabapathy, J Prague, MA Ghatei, SR Bloom, GH Trew, WS Dhillo.'
Year(s) Of Engagement Activity 2015
URL http://www.eshre2015.eu/
 
Description Plenary Lecture: Kisspeptin / neurokinin B Pathways: Regulating Emotion and Treatment of Menopausal Symptoms American Endocrine Society meeting, Chicago April 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk-Plenary Lecture: Kisspeptin / neurokinin B Pathways: Regulating Emotion and Treatment of Menopausal Symptoms
American Endocrine Society meeting, Chicago April 2018
Year(s) Of Engagement Activity 2018
 
Description Poster presentation at the American Endocrine Society Annual Conference, March 2015, San Diego 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster presentation at the American Endocrine Society Annual Conference, March 2015, San Diego.
'Kisspeptin- A novel test of hypothalamic function in older men.
A Abbara, CN Jayasena, S Narayanaswamy, C Izzi-Engbeaya, AN Comninos, A Colbentz, Z Malik, Z Sarang, M Sridharan, D Peters, MA Ghatei, SR Bloom, WS Dhillo.'
Year(s) Of Engagement Activity 2015
URL https://endo.confex.com/endo/2015endo/webprogram/Paper21182.html
 
Description Poster presentation at the COST Action BM1105, Joint Scientific Meeting and Training School, Monash University Prato Center, 27th-29th April 2015. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster presentation at the COST Action BM1105, Joint Scientific Meeting and Training School, Monash University Prato Center, 27th-29th April 2015.
'The Gonadotrophin Response to Intravenous Kisspeptin Positively Correlates with Baseline Estradiol Levels in Healthy Women during the Early Follicular Phase of the Menstrual Cycle
S. Narayanaswamy, C. Jayasena, N. Ng, R. Ratnasabapathy, J. Prague, D. Papadopoulou, A. Comninos, A. Abbara, M. Ghatei, S. Bloom & W. Dhillo.'
Year(s) Of Engagement Activity 2015
URL http://www.gnrhnetwork.eu/hhn_home/hhn-cost/hhn-trainingeducation/hhn-trainingschool/hhn-third_train...
 
Description Scientific talk at secondary school (Ealing) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Talk about science and research which stimulated interesting discussion.
Year(s) Of Engagement Activity 2015
 
Description Talk at Annual Academic Meeting/ Blair Bell Research Society, Royal College of Obstetricians and Gynaecologists, London Jan 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Royal College of Obstetricians and Gynaecologists, London
Year(s) Of Engagement Activity 2018
 
Description The future of clinical academic training at Tony Gordon's conference in Great Hall, King's College London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact The future of clinical academic training at Tony Gordon's conference in Great Hall, King's College London-Feb 2018
Year(s) Of Engagement Activity 2018
 
Description The importance of academic medicine and supporting academic clinical careers Pathway to Independence - developing future clinical academic leaders in cancer research, Moller Centre Cambridge, Nov 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The importance of academic medicine and supporting academic clinical careers Pathway to Independence - developing future clinical academic leaders in cancer research
Moller Centre Cambridge, Nov 2016
Year(s) Of Engagement Activity 2016
 
Description Translating Novel Hormones into New Therapies for Reproductive Disorders 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Talk/Seminar Translating Novel Hormones into New Therapies for Reproductive Disorders
Year(s) Of Engagement Activity 2019
 
Description Update on clinical kisspeptin studies Kisspeptin 2017, Orlando USA, March 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Update on clinical kisspeptin studies
Kisspeptin 2017, Orlando USA, March 2016
Year(s) Of Engagement Activity 2016
 
Description media interest in kisspeptin study 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact You tube video: https://www.youtube.com/watch?v=KICd5XL2404; https://www.youtube.com/watch?v=r5SwbgvfHPs

BBC News Health website: http://www.bbc.co.uk/news/health-28352363
The Telegraph: http://www.telegraph.co.uk/health/healthnews/10976037/First-babies-born-from-safe-new-IVF-technique.html
The Times: http://www.thetimes.co.uk/tto/health/news/article4151740.ece
The Independent: http://www.independent.co.uk/life-style/health-and-families/health-news/dozen-babies-born-using-safer-ivf-treatment-9616462.html
Daily Mail: http://www.dailymail.co.uk/health/article-2343490/Our-natural-IVF-baby-Family-celebrate-birth-little-Heath-pioneering-new-hormone-technique-thats-safer-mum.html
Science Daily: http://www.sciencedaily.com/releases/2014/07/140718214944.htm
Fox News: http://www.foxnews.com/health/2014/07/18/new-method-for-stimulating-ovulation-may-make-ivf-safer-says-study/
New York Daily News: http://www.nydailynews.com/life-style/health/new-ivf-technique-safer-report-article-1.1874556
Imperial College: http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/newssummary/news_18-7-2014-11-49-26
The Times of India: http://timesofindia.indiatimes.com/home/science/Researchers-make-in-vitro-fertilisation-safer-for-women/articleshow/38679856.cms
Nature World News: http://www.natureworldnews.com/articles/8142/20140719/kisspeptin-makes-ivf-safer-researchers.htm
Medical Daily: http://www.medicaldaily.com/kisspeptin-works-well-women-seeking-ivf-treatment-and-its-safer-293972
International Business Times: http://au.ibtimes.com/articles/559726/20140721/hcg-kisspeptin-poly-cystic-ovarian-syndrome-fertility.htm#.VAX2VPldXAk
The Health Site: http://www.thehealthsite.com/news/hormone-kisspeptin-to-make-ivf-safer-in-women/
Growing your baby: http://www.growingyourbaby.com/2014/07/23/new-successful-ivf-technique-could-be-safer-for-women-researchers-say/
Bustle: http://www.bustle.com/articles/32553-new-fertility-drug-kisspeptin-means-ivf-is-safer-than-ever
The Visible Embryo: http://www.visembryo.com/story3084.html
Times Live: http://www.timeslive.co.za/lifestyle/2014/07/22/ivf-could-be-made-safer-thanks-to-new-research
International Federation of Gynecology and Obstetrics: http://www.figo.org/news/kisspeptin-treatment-%E2%80%98could-make-ivf-safer%E2%80%99-0014534
Eureka Alert: http://www.eurekalert.org/pub_releases/2014-07/icl-ntf071614.php
My Sinchew: http://www.mysinchew.com/node/100143?tid=163
Delhi Daily News: http://www.delhidailynews.com/news/IVF-made-safer-for-women-1405839281/
Executives News: http://executivesnews.com/safer-kisspeptin-ivf-shows-promise
Daily News (USA): http://www.dailynewsen.com/health/new-method-for-stimulating-ovulation-may-make-ivf-safer-study-says-h2521518.html
Longevity Live: http://www.longevitylive.com/health-studies/expert-advice-body/chocolate-hormone-may-answer-pregnancy-problems/
Healthcare and Wellness: http://www.longevitylive.com/health-studies/expert-advice-body/chocolate-hormone-may-answer-pregnancy-problems/
Medical News Today: http://www.medicalnewstoday.com/articles/279785.php
Commuter Express: http://www.commuterexpress.com.ph/fertilization-therapy-made-safer/
The British Post: http://news.thebritishpost.com/news/dozen-babies-born-using-safer-ivf-treatment
Chennai Online news: http://news.chennaionline.com/international/Researchers-make-IVF-safer-for-women/3514c802-119a-4162-9f5e-482f4dcc569f.col
NHS: http://www.nhs.uk/news/2014/07July/Pages/kisspeptin-ivf-could-prevent-ovarian-hyperstimulation.aspx

Significant interest from public
Year(s) Of Engagement Activity 2014
 
Description news article in national newspaper 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact dissemination of resaecrh to public
Year(s) Of Engagement Activity 2013
URL http://www.telegraph.co.uk/health/healthnews/10121900/First-baby-born-using-new-lower-risk-IVF-treat...
 
Description newspaper article on research findings 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact dissemination of research finds to public:
http://www.itv.com/news/london/update/2013-06-18/new-form-of-ivf-pioneered-in-london/:
http://www.newscientist.com/article/dn23714-worlds-first-baby-born-from-natural-ivf.html#.UcM6yzvVDTo:
http://www.dailymail.co.uk/health/article-2343490/Our-natural-IVF-baby-Family-celebrate-birth-little-Heath-pioneering-new-hormone-technique-thats-safer-mum.html;
http://www.guardian.co.uk/society/2013/jun/18/hormone-breakthrough-fertility-kisspeptin;


dissemination of research finds to public
http://www.nydailynews.com/life-style/health/baby-born-safer-ivf-treatment-article-1.1377412?localLinksEnabled=false;
http://www.sciencedaily.com/releases/2013/06/130617142035.htm
Year(s) Of Engagement Activity 2013
URL http://www.telegraph.co.uk/health/healthnews/10121900/First-baby-born-using-new-lower-risk-IVF-treat...