Strategic Appointment of Professor B Peault.

Lead Research Organisation: University of Edinburgh
Department Name: Centre for Cardiovascular Science

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

10 25 50
 
Description Presidence of the Stem Cell sub-committee of the French AFM-Telethon
Geographic Reach Asia 
Policy Influence Type Participation in advisory committee
Impact Improvement in treatment of genetic diseases of muscle
 
Description Scientific Advisory Board of the Agence Nationale pour la Recherche
Geographic Reach Asia 
Policy Influence Type Participation in advisory committee
 
Description Autologous Osteogenic Stem Cells to Prevent and Heal Non-union Fractures
Amount £33,000 (GBP)
Organisation Chief Scientist Office 
Sector Public
Country United Kingdom
Start 03/2019 
End 07/2019
 
Description Cardiovascular Regenerative Medicine Centre Award
Amount £2,500,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2013 
End 09/2017
 
Description Characterization of equine perivascular stem cells
Amount £250,000 (GBP)
Organisation Horserace Betting Levy Board 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2014 
End 05/2017
 
Description Dkk1 antagonism for stromal vascular fraction (SVF) mediated bone repair
Amount $72,520 (USD)
Organisation Department of Defense 
Sector Public
Country United States
Start 09/2018 
End 12/2023
 
Description Harnessing fat-derived pericytes for bone repair
Amount $5,400,000 (USD)
Organisation California Institute for Regenerative Medicine 
Sector Academic/University
Country United States
Start 02/2011 
End 07/2014
 
Description MRC Stem Cell Strategic Award
Amount £500,090 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 05/2010 
End 04/2013
 
Description Tissue regenerative cells in fat-derived Lipogems
Amount € 170,000 (EUR)
Organisation Lipogems 
Sector Private
Country Italy
Start 01/2014 
End 04/2018
 
Description Vascular Injury and Repair in Premature Coronary Artery Disease: Understanding the Role of Endothelial Progenitor Cells
Amount £213,470 (GBP)
Funding ID CZB/4/812 
Organisation Chief Scientist Office 
Sector Public
Country United Kingdom
Start 08/2011 
End 07/2014
 
Title Osteogenesis from pericytes 
Description This has been published in the Journal of Visualized Experiments (video publication): James, A., Zara, J., Corselli, M., Chiang, M., Siu, R., Scott, V., Lee, M., Ting, K., P?ault, B., Soo, C. (2011). Use of Human Perivascular Stem Cells for Bone Regeneration. JoVE. In press 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2011 
Provided To Others? Yes  
Impact The development of this research material has served our current preclinical validation of pericytes for bone repair 
 
Description Cardiac repair, from fibrosis to regeneration 
Organisation University of California, Los Angeles (UCLA)
Country United States 
Sector Academic/University 
PI Contribution Expertise on pericytes and the contribution thereof to cardiac fibrosis
Collaborator Contribution Expertise on endothelial cells. Contribution of reporter mice.
Impact This is a starting collaboration. A grant application has been submitted.
Start Year 2014
 
Description Cardiovascular Development and Repair 
Organisation UCLA Health
Department Division of Cardiology
Country United States 
Sector Academic/University 
PI Contribution Human perivascular stem cell identification and characterization
Collaborator Contribution Transgenic mouse models of cardiovascular repair
Impact Grant application pending
Start Year 2012
 
Description Cell therapy of urinary incontinence 
Organisation UCLA Health
Department Department of Obstetrics and Gynecology
Country United States 
Sector Academic/University 
PI Contribution We provide purified native human mesenchymal stem cells to be tested in animal models (rats) of urinary incontinence.
Collaborator Contribution Animal models. Expertise in the targeted pathology.
Impact Recently initiated collaboration. Grant application in project.
Start Year 2013
 
Description Novel markers of human multipotent regenerative cells 
Organisation Becton, Dickinson and Company
Department BD Biosciences
Country United States 
Sector Private 
PI Contribution Identification and validation of novel surface markers of human mesenchymal stem cells
Collaborator Contribution Supply of multiple antibodies
Impact Collaboration recently initiated; in progress
Start Year 2013
 
Description Pericytes for bone regeneration 
Organisation University of California, Los Angeles (UCLA)
Department Orthopaedic Surgery UCLA
Country United States 
Sector Academic/University 
PI Contribution Preclinical validation of human pericytes for bone regeneration
Collaborator Contribution Animal models, biomaterials, pre-clinical expertise
Impact - Early Translation grant from the California Institute for Regenerative Medicine. 2011-2014. M$ 5.4. "Harnessing Perivascular Stem Cells for Bone Regeneration". PI: B. Peault. Collaboration at the University of California at Los Angeles with Chia Soo (co-PI), Eric Ting and Ben Wu (co-Is). Also a collaboration and exchange program between UCLA and the University of Edinburgh Publications: Xinli Zhang, Bruno Peault, Weiwei Chen, Weiming Li, Mirko Corselli, Min Lee, Ron Siu, Pang Shen, Zhong Zheng, Jia Shen, Jinny Kwak, Janette Zara, Feng Chen, Hong Zhang, Zack Yin, Ben Wu, Kang Ting and Chia Soo. (2011) Nell-1 harnesses the osteogenic and angiogenic potentials of purified human pericytes.Tissue Engineering. 17(19-20): 2497-2509 James, A., Zara, J., Corselli, M., Chiang, M., Siu, R., Scott, V., Lee, M., Ting, K., Péault, B., Soo, C. (2011). Use of Human Perivascular Stem Cells for Bone Regeneration. JoVE. In press
Start Year 2010
 
Description Perivascular cell involvement in pathologic brain calcification 
Organisation University of Oxford
Department Neuropathology Department
Country United Kingdom 
Sector Academic/University 
PI Contribution Phenotypic characterization of perivascular cell compartments in human brain.
Collaborator Contribution Sections of pathologic brain specimens. Expertise in the targeted pathologies.
Impact This collaboration has just started
Start Year 2013
 
Description Perivascular control of chondrocyte maintenance and regeneration 
Organisation University of California, Los Angeles (UCLA)
Department Orthopaedic Surgery UCLA
Country United States 
Sector Academic/University 
PI Contribution Characterization and purification of human perivascular cells
Collaborator Contribution Chondrocyte biology, in culture and in vivo
Impact Grant application submitted
Start Year 2013
 
Description Regenerative potential of microfragmented fat tissue 
Organisation Lipogems
Country Italy 
Sector Private 
PI Contribution We have demonstrated the superior ability of micro-fragmented fat tissue, as compared to enzymatically digested fat, in terms of growth factor/cytokine secretion
Collaborator Contribution Supply of devices for adipose tissue micro-fragmentation
Impact One article has been submitted for publication. Results have been presented at several conferences
Start Year 2016
 
Description Role of pericytes in solid tumors 
Organisation University of California, Los Angeles (UCLA)
Department Pathology
Country United States 
Sector Academic/University 
PI Contribution Characterization/purification/culture of human pericytes
Collaborator Contribution Models of skin and gynaecologic tumors
Impact One peer-reviewed publication. Grant application pending
Start Year 2012
 
Description Role of pericytes in the support of chondrogenic cells 
Organisation University of California, Los Angeles (UCLA)
Country United States 
Sector Academic/University 
PI Contribution Expertise on pericyte identification, isolation and culture
Collaborator Contribution Expertise in cartilage regeneration. Animal models.
Impact This is a recently started collaboration. Another grant will be applied for in 2015.
Start Year 2014
 
Description Vascular Cell Repair of Coronary Arteries 
Organisation University of Edinburgh
Department Centre for Cardiovascular Science
Country United Kingdom 
Sector Academic/University 
PI Contribution Caracterisation of vascular progenitor cells
Collaborator Contribution Novel model of pericyte activity
Impact Grant of The CSO: "Vascular Injury and Repair in Premature Coronary Artery Disease: Understanding the Role of Endothelial Progenitor Cells"
Start Year 2011
 
Title Autologous purified stem cells fort bone repair 
Description Combination of autologous purified stem cells, biocompatible scaffold and osteogenic growth factor for bone repair/spine fusion. Under preclinical validation. 
Type Therapeutic Intervention - Cellular and gene therapies
Current Stage Of Development Refinement. Non-clinical
Year Development Stage Completed 2012
Development Status Actively seeking support
Impact Immediate accessibility of the stem cell product. No cell culture required. Much improved purity of the stem cells to be transplanted. 
 
Title Autologous stem cells for cartilage repair 
Description Cartilage regeneration from purified autologous stem cells. Under basic investigation. Large animal model under development 
Type Therapeutic Intervention - Cellular and gene therapies
Current Stage Of Development Initial development
Year Development Stage Completed 2012
Development Status Under active development/distribution
Impact Novel cell therapy of cartilage defects 
 
Description AFM study section "Gene and Cell Therapy" (Paris) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Evaluate projects submitted to French AFM Telethon

...
Year(s) Of Engagement Activity 2012
 
Description AFM Meeting, Paris Oct 2014 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Evaluation of projects

--
Year(s) Of Engagement Activity 2014
 
Description AFM Scientific Board (Versailles/France) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Definition of the goals and strategy of the AFM in 2013

Appointment as study section President
Year(s) Of Engagement Activity 2012
 
Description AFM study section "Gene cell therapy" (Paris) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Evaluation of projects submitted to AFM/Telethon

...
Year(s) Of Engagement Activity 2011
 
Description AFM study section 2013 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Participants in your research and patient groups
Results and Impact About 50 proposals discussed

Grants and fellowships awarded
Year(s) Of Engagement Activity 2013
 
Description Advisory Board, Karolinska Institute 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Interviews of multiple investigators during a 2-day visit at the Karolinska Institute

Release of a consensus report from the site visit committee
Year(s) Of Engagement Activity 2011
 
Description Article in the Sunday Magazine 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Telephone interview by a journalist from the Sunday Magazine, following the publication of our results on bone regeneration (June 2012). An article was published the following Sunday.

NA
Year(s) Of Engagement Activity 2012
 
Description BHF REA(2) External Advisory Board Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Discussion

--
Year(s) Of Engagement Activity 2014
 
Description BHF Site Visit (London) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Regular site visit

Prof. Xu's grant was funded
Year(s) Of Engagement Activity 2011
 
Description BHF Synergy meeting. Oxford. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact Establishment of collaborations between BHF grantees.

BHF Center Grant
Year(s) Of Engagement Activity 2013
 
Description Edinburgh Stem Cell School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Local course on stem cells, for graduate and post-graduate students

...
Year(s) Of Engagement Activity 2011
 
Description Filmed interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Lay interview on the future of stem cell therapies, by Global Science Productions (Los Angeles) (not yet released; expected mid-2019)
Year(s) Of Engagement Activity 2018
 
Description Filmed interview, Centre National de la Recherche Scientifique 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Filmed interview included in a movie describing the life and carreer of Nicole LeDouarin, the famous developmental biologist

Public release of the movie
Year(s) Of Engagement Activity 2011
 
Description Grant study section 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact President, Study Section on Stem Cells from Association Francaise contre les Myopathies (AFM-Telethon)
Year(s) Of Engagement Activity 2012,2013,2014,2015,2016,2017,2018,2019
 
Description Grant study section 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact ERA-Net on Cardiovascular Disease (ERA-CVD)
Year(s) Of Engagement Activity 2016,2018
 
Description Grant study section 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Medical Research Council (MRC). DPFS Panel
Year(s) Of Engagement Activity 2019
 
Description Grant study section 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact National Science Center, Warsaw, Poland
Year(s) Of Engagement Activity 2018
 
Description Grant study section 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact RHU (annual call of the French Ministry of Science on Innovative Therapies)
Year(s) Of Engagement Activity 2017,2018,2019
 
Description IFR14/IU ICAN Conference (Paris) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Regular conference

...
Year(s) Of Engagement Activity 2012
 
Description Inaugural Professorship Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact A large lay audience, including numerous school pupils, attended my inaugural lecture (full amphitheater). Many came to discuss with me afterwards.

Paradoxically, I received collaboration offers from academic colleagues after my lecture, in addition to comments and questions from laypeople...
Year(s) Of Engagement Activity 2011
 
Description Inserm School (Paris) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Annual conference for medical graduate students

...
Year(s) Of Engagement Activity 2012
 
Description Keystone Symposia, Colorado March 2014 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact International conference

Contacts
Year(s) Of Engagement Activity 2014
 
Description Molecular & Developmental Genetics seminar (Buffalo/NY) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Invited seminar from Prof. Ken Gross

Collaboration
Year(s) Of Engagement Activity 2011
 
Description Nystem review meeting (Virginia) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Review of projects submitted to NYSTEM

...
Year(s) Of Engagement Activity 2012
 
Description Online debate 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Ask the Experts: current obstacles and future developments in cell culture

www.future-science-group.com
Year(s) Of Engagement Activity 2018
 
Description PRTS Paris 2013 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact 270 applications were received

About 30 projects will be supported (final outcome still pending)
Year(s) Of Engagement Activity 2013
 
Description Presidence of the Study Section on Stem Cells; AFM/Telethon 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact The first meeting of the Study Section will take place in January 2013.

To be determined later
Year(s) Of Engagement Activity 2012
 
Description Press Conference Newcastle 2013 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Press conference on the use of stem cells in medicine and its controversies.

Several press releases
Year(s) Of Engagement Activity 2013
 
Description Public debate on stem cell research and medical applications. Los Angeles. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Public debate on stem cells organized by the French Consulate in November 2012 in a Los Angeles theater (Kabbaz theater). Lay audience asked multiple questions.

Press release
Year(s) Of Engagement Activity 2012
 
Description Stem Cell Awareness Day of the California Institute for Regenerative Medicine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Schools
Results and Impact Presentation of stem cell research to a class of about 30 pupils at a High School in Los Angeles

The school asked to visit our laboratories i 2013
Year(s) Of Engagement Activity 2012
 
Description Stem Cells Commission 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Evaluation of projects

--
Year(s) Of Engagement Activity 2014
 
Description Symposium Day, Edinburgh June 2014 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Discussion group

--
Year(s) Of Engagement Activity 2014
 
Description Visit of our Center by the Ambassador of France in the USA and General Consul of France in Los Angeles 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact The Ambassador of France, Consul General of Los Angeles and their communication staff visited my laboratory and the Broad Stem Cell Research Center at UCLA in November 2012. I co-organized the visit and made a general presentation of our work.

Multiple contacts
Year(s) Of Engagement Activity 2012