Affinity of Th1 and Th2 T cell receptors in an inducible lung disease model

Lead Research Organisation: Imperial College London
Department Name: Biological Sciences

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Ingram RJ (2009) A role of cellular prion protein in programming T-cell cytokine responses in disease. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology

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Boyton RJ (2006) HLA-C and killer cell immunoglobulin-like receptor genes in idiopathic bronchiectasis. in American journal of respiratory and critical care medicine

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Boyton RJ (2002) Is selection for TCR affinity a factor in cytokine polarization? in Trends in immunology

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Reynolds CJ (2018) Lung Defense through IL-8 Carries a Cost of Chronic Lung Remodeling and Impaired Function. in American journal of respiratory cell and molecular biology

 
Description Asthma UK Project
Amount £116,822 (GBP)
Organisation Asthma UK 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2003 
End 05/2006
 
Description Asthma UK project
Amount £49,930 (GBP)
Organisation Asthma UK 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2009 
End 10/2010
 
Description BBSRC
Amount £757,586 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2010 
End 03/2014
 
Description Clinical Training Fellowship
Amount £287,078 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2013 
End 06/2017
 
Description Immune regulation in the Lung (Welton Foundation)
Amount £157,713 (GBP)
Organisation Welton Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2008 
End 09/2014
 
Description MRC Asthma Centre Studentship
Amount £150,000 (GBP)
Organisation Medical Research Council (MRC) 
Department Medical Research Council (MRC) Centre Cambridge
Sector Public
Country United Kingdom
Start 10/2009 
End 09/2013
 
Description MRC Asthma Centre Studentship
Amount £150,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2006 
End 09/2010
 
Description MRC and Asthma UK Centre
Amount £3,989,218 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 05/2005 
End 09/2015
 
Description NHLI Foundation PhD studentship
Amount £150,000 (GBP)
Organisation National Heart and Lung Institute Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2005 
End 01/2008
 
Description NIH NIAID
Amount $5,300,000 (USD)
Organisation National Institute of Allergy and Infectious Diseases (NIAID) 
Sector Public
Country United States
Start 02/2011 
End 03/2015
 
Description Royal Brompton Hospital Trust
Amount £60,843 (GBP)
Organisation Royal Brompton & Harefield NHS Foundation Trust 
Sector Public
Country United Kingdom
Start 01/2009 
End 01/2011
 
Description Royal Brompton Hospital Trust
Amount £24,000 (GBP)
Organisation Royal Brompton & Harefield NHS Foundation Trust 
Sector Public
Country United Kingdom
Start 01/2008 
End 04/2010
 
Description Royal Brompton and Harefield NHS Trust Clinical Research Committee
Amount £19,820 (GBP)
Organisation Royal Brompton & Harefield NHS Foundation Trust 
Sector Public
Country United Kingdom
Start 09/2004 
End 05/2006
 
Description Wellcome Trust Centre for Respiratory Infection co-applicant
Amount £1,500,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2008 
End 05/2011
 
Description Wellcome Trust/NIH PhD studentship
Amount £70,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2011 
End 09/2015
 
Description Welton Foundation Project Grant
Amount £70,740 (GBP)
Organisation Welton Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2003 
End 10/2010
 
Description humanised transgenic model: influence of tolerance and TLR ligands
Amount £99,646 (GBP)
Funding ID 05/045 
Organisation Asthma UK 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2006 
End 06/2008
 
Title Transgenic lines 
Description Made multiple new transgenic mice (5xTCR, 3x Lung targeted, 1x inducible) have been generated. These can be used to study Th1 and Th2 responses. 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Provided To Others? No  
Impact Able to study the impact of immunity on in vivo disease models of allergy, asthma, infection and autoimmunity 
URL http://bmcbiol.biomedcentral.com/articles/10.1186/1741-7007-12-32
 
Description Brian Sauer/Stowers Institute 
Organisation Stowers Institute for Medical Research
Country United States 
Sector Academic/University 
PI Contribution NA
Collaborator Contribution Flowed stop cassette used in generating inducible transgenic lines
Impact NA
 
Description Center of Respiratory Infection 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-applicant on the successful CRI application to Wellcome Trust
Collaborator Contribution Access to a multiparameter FACS facility at St Mary's.
Impact An IC Center of Respiratory Infection has been set up to enhance collaborative work in this area
Start Year 2008
 
Description Diane Mathis/Christophe Benoist - Brigham Hosp. 
Organisation Brigham and Women's Hospital
Country United States 
Sector Hospitals 
PI Contribution NA
Collaborator Contribution T Cell receptor alpha and beta chain cassette used in generating T cell receptor transgenic lines
Impact NA
 
Description Dr David Cole 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Supplying sequence data for Th1, Th2 and Th17 TCR to study binding affinity by Biacore
Collaborator Contribution David Cole is making soluble TCRs
Impact None yet
Start Year 2012
 
Description Helen Bodmer/Jenner Institute 
Organisation University of Oxford
Department Jenner Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution NA
Collaborator Contribution HEL expression cassette used in generating lung targeted antigen expressing lines
Impact NA
 
Description Jeffrey Whitset/Children's Hospital Medical Centre, USA 
Organisation Cincinnati Children's Hospital Medical Center
Department Section of Neonatology, Perinatal and Pulmonary Biology
Country United States 
Sector Academic/University 
PI Contribution NA
Collaborator Contribution CC10 promoter used in generating lung targeted transgenic lines
Impact NA
 
Description John Altman/NIH 
Organisation Emory University
Department Emory Vaccine Centre
Country United States 
Sector Academic/University 
PI Contribution NA
Collaborator Contribution H-2Ag7/PLP 56-70 and H-2Ag7/GAD65 534-543 tetramers used in T cell recptor binding studies
Impact NA
 
Description MRC/Asthma UK Asthma Centre co-applicant 
Organisation King's College London
Department MRC & Asthma UK Centre in Allergic Mechanisms of Asthma
Country United Kingdom 
Sector Academic/University 
PI Contribution NA
Collaborator Contribution Access to facilities including FACs, FACs sorting, real-time PCR, murine lung function equipment and MRC PhD studentship
Impact NA
 
Description Maggie Dallman/Imperial 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution NA
Collaborator Contribution betam70 Cre transgenic mice - used in generating inducible transgenic lines
Impact NA
 
Description CBS Staff training talks 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Presentation to show IVIS and transgenic technology

Better understanding of IVIS and transgenic technology
Year(s) Of Engagement Activity 2012,2013
 
Description School Science Projects 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact CR, postdoctoral scientist, taught science in a series of 2 day practical sessions (3x per year) to secondary school children to enhance the children's interest in science.

The children were very motivated by these sessions and did visit an IC laboratory.
Year(s) Of Engagement Activity 2008,2009,2010,2011,2012,2013,2014
URL http://www3.imperial.ac.uk/outreach
 
Description School Visits. London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact 15-20 pupils per class attend a talk about genetics and medicine with a Q & A session afterwards.

Children more interested in science
Year(s) Of Engagement Activity 2007,2008,2009,2010,2011,2012,2013,2014