Affinity of Th1 and Th2 T cell receptors in an inducible lung disease model
Lead Research Organisation:
Imperial College London
Department Name: Biological Sciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
- Imperial College London, United Kingdom (Collaboration, Fellow, Lead Research Organisation)
- University of Oxford, United Kingdom (Collaboration)
- Cincinnati Children's Hospital Medical Center (Collaboration)
- Cardiff University, United Kingdom (Collaboration)
- Brigham and Women's Hospital (Collaboration)
- Emory University, United States (Collaboration)
- Stowers Institute of Medical Research, United States (Collaboration)
- King's College London, United Kingdom (Collaboration)
People |
ORCID iD |
| Rosemary Jane Boyton (Principal Investigator / Fellow) |
Publications
Campbell JD
(2009)
Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression.
in The Journal of experimental medicine
Griesenbach U
(2006)
Effect of tolerance induction to immunodominant T-cell epitopes of Sendai virus on gene expression following repeat administration to lung.
in Gene therapy
Ingram RJ
(2009)
A role of cellular prion protein in programming T-cell cytokine responses in disease.
in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Reynolds C
(2007)
Toll-like receptors 2 and 4 and innate immunity in neutrophilic asthma and idiopathic bronchiectasis.
in Thorax
Reynolds C
(2009)
Natural killer T cells in bronchial biopsies from human allergen challenge model of allergic asthma.
in The Journal of allergy and clinical immunology
Reynolds C
(2014)
Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.
in BMC biology
Reynolds CJ
(2018)
Lung Defense through IL-8 Carries a Cost of Chronic Lung Remodeling and Impaired Function.
in American journal of respiratory cell and molecular biology
| Description | Asthma UK Project |
| Amount | £116,822 (GBP) |
| Organisation | Asthma UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2003 |
| End | 05/2006 |
| Description | Asthma UK project |
| Amount | £49,930 (GBP) |
| Organisation | Asthma UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2009 |
| End | 10/2010 |
| Description | BBSRC |
| Amount | £757,586 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2010 |
| End | 03/2014 |
| Description | Clinical Training Fellowship |
| Amount | £287,078 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2013 |
| End | 06/2017 |
| Description | Immune regulation in the Lung (Welton Foundation) |
| Amount | £157,713 (GBP) |
| Organisation | Welton Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2008 |
| End | 09/2014 |
| Description | MRC Asthma Centre Studentship |
| Amount | £150,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Department | Medical Research Council (MRC) Centre Cambridge |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2009 |
| End | 09/2013 |
| Description | MRC Asthma Centre Studentship |
| Amount | £150,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2006 |
| End | 09/2010 |
| Description | MRC and Asthma UK Centre |
| Amount | £3,989,218 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2005 |
| End | 09/2015 |
| Description | NHLI Foundation PhD studentship |
| Amount | £150,000 (GBP) |
| Organisation | National Heart and Lung Institute Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2005 |
| End | 01/2008 |
| Description | NIH NIAID |
| Amount | $5,300,000 (USD) |
| Organisation | National Institute of Allergy and Infectious Diseases (NIAID) |
| Sector | Public |
| Country | United States |
| Start | 02/2011 |
| End | 03/2015 |
| Description | Royal Brompton Hospital Trust |
| Amount | £60,843 (GBP) |
| Organisation | Royal Brompton & Harefield NHS Foundation Trust |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2009 |
| End | 01/2011 |
| Description | Royal Brompton Hospital Trust |
| Amount | £24,000 (GBP) |
| Organisation | Royal Brompton & Harefield NHS Foundation Trust |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2008 |
| End | 04/2010 |
| Description | Royal Brompton and Harefield NHS Trust Clinical Research Committee |
| Amount | £19,820 (GBP) |
| Organisation | Royal Brompton & Harefield NHS Foundation Trust |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2004 |
| End | 05/2006 |
| Description | Wellcome Trust Centre for Respiratory Infection co-applicant |
| Amount | £1,500,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2008 |
| End | 05/2011 |
| Description | Wellcome Trust/NIH PhD studentship |
| Amount | £70,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2011 |
| End | 09/2015 |
| Description | Welton Foundation Project Grant |
| Amount | £70,740 (GBP) |
| Organisation | Welton Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2003 |
| End | 10/2010 |
| Description | humanised transgenic model: influence of tolerance and TLR ligands |
| Amount | £99,646 (GBP) |
| Funding ID | 05/045 |
| Organisation | Asthma UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2006 |
| End | 06/2008 |
| Title | Transgenic lines |
| Description | Made multiple new transgenic mice (5xTCR, 3x Lung targeted, 1x inducible) have been generated. These can be used to study Th1 and Th2 responses. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Provided To Others? | No |
| Impact | Able to study the impact of immunity on in vivo disease models of allergy, asthma, infection and autoimmunity |
| URL | http://bmcbiol.biomedcentral.com/articles/10.1186/1741-7007-12-32 |
| Description | Brian Sauer/Stowers Institute |
| Organisation | Stowers Institute for Medical Research |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | NA |
| Collaborator Contribution | Flowed stop cassette used in generating inducible transgenic lines |
| Impact | NA |
| Description | Center of Respiratory Infection |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Co-applicant on the successful CRI application to Wellcome Trust |
| Collaborator Contribution | Access to a multiparameter FACS facility at St Mary's. |
| Impact | An IC Center of Respiratory Infection has been set up to enhance collaborative work in this area |
| Start Year | 2008 |
| Description | Diane Mathis/Christophe Benoist - Brigham Hosp. |
| Organisation | Brigham and Women's Hospital |
| Country | United States |
| Sector | Hospitals |
| PI Contribution | NA |
| Collaborator Contribution | T Cell receptor alpha and beta chain cassette used in generating T cell receptor transgenic lines |
| Impact | NA |
| Description | Dr David Cole |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Supplying sequence data for Th1, Th2 and Th17 TCR to study binding affinity by Biacore |
| Collaborator Contribution | David Cole is making soluble TCRs |
| Impact | None yet |
| Start Year | 2012 |
| Description | Helen Bodmer/Jenner Institute |
| Organisation | University of Oxford |
| Department | Jenner Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NA |
| Collaborator Contribution | HEL expression cassette used in generating lung targeted antigen expressing lines |
| Impact | NA |
| Description | Jeffrey Whitset/Children's Hospital Medical Centre, USA |
| Organisation | Cincinnati Children's Hospital Medical Center |
| Department | Section of Neonatology, Perinatal and Pulmonary Biology |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | NA |
| Collaborator Contribution | CC10 promoter used in generating lung targeted transgenic lines |
| Impact | NA |
| Description | John Altman/NIH |
| Organisation | Emory University |
| Department | Emory Vaccine Centre |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | NA |
| Collaborator Contribution | H-2Ag7/PLP 56-70 and H-2Ag7/GAD65 534-543 tetramers used in T cell recptor binding studies |
| Impact | NA |
| Description | MRC/Asthma UK Asthma Centre co-applicant |
| Organisation | King's College London |
| Department | MRC & Asthma UK Centre in Allergic Mechanisms of Asthma |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NA |
| Collaborator Contribution | Access to facilities including FACs, FACs sorting, real-time PCR, murine lung function equipment and MRC PhD studentship |
| Impact | NA |
| Description | Maggie Dallman/Imperial |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NA |
| Collaborator Contribution | betam70 Cre transgenic mice - used in generating inducible transgenic lines |
| Impact | NA |
| Description | CBS Staff training talks |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation to show IVIS and transgenic technology Better understanding of IVIS and transgenic technology |
| Year(s) Of Engagement Activity | 2012,2013 |
| Description | School Science Projects |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | CR, postdoctoral scientist, taught science in a series of 2 day practical sessions (3x per year) to secondary school children to enhance the children's interest in science. The children were very motivated by these sessions and did visit an IC laboratory. |
| Year(s) Of Engagement Activity | 2008,2009,2010,2011,2012,2013,2014 |
| URL | http://www3.imperial.ac.uk/outreach |
| Description | School Visits. London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | 15-20 pupils per class attend a talk about genetics and medicine with a Q & A session afterwards. Children more interested in science |
| Year(s) Of Engagement Activity | 2007,2008,2009,2010,2011,2012,2013,2014 |