Does deregulated activation of Rho family G-proteins define a novel subgroup of B cell malignancy, with shared molecular

Lead Research Organisation: University of Leeds
Department Name: School of Medicine

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
 
Description AICR Project Grant
Amount £150,000 (GBP)
Organisation Association for International Cancer Research 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2007 
End 10/2010
 
Description CRUK Senior Clinical Fellowship
Amount £1,300,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2009 
End 12/2014
 
Description LLR Project grant
Amount £150,000 (GBP)
Organisation Leukaemia and Lymphoma Research 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2011 
End 12/2014
 
Description Leukaemia Research Programme Grant
Amount £250,000 (GBP)
Organisation Leukaemia and Lymphoma Research 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2007 
End 07/2012
 
Description Pump priming funding
Amount £30,000 (GBP)
Organisation Yorkshire Cancer Research 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2006 
End 07/2007
 
Description YCR project grant
Amount £150,000 (GBP)
Organisation Yorkshire Cancer Research 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2010 
End 01/2013
 
Title Polyconal antibody to BLIMP1 
Description We have raised a particularly useful set of polyclonal antibodies to an important transcription factor. These work better for certain applications than other antibodies 
Type Of Material Antibody 
Year Produced 2006 
Provided To Others? Yes  
Impact Contributed to 16901790 18953407 
URL http://europepmc.org/abstract/MED/16901792
 
Description Fuchs Lab Rockefeller 
Organisation Rockefeller University
Department Laboratory of Mammalian Cell Biology and Development Rockefeller
Country United States 
Sector Academic/University 
PI Contribution Raised a unique antibody to the transcription factor BLIMP1, and described the expression pattern in human skin. Using this information I pro-actively contacted the Fuchs lab, to ask about establishing a collaboration. I provided the antibody, lentiviral and normal expression vectors for BLIMP1 and promoter reporter constructs. I provided advice on a murine phenotype, based on the observed expression patterns in human.
Collaborator Contribution The publication has raised the profile of the laboratory and resulted in numerous requests for our reagents from Europe, USA and Australia.
Impact 16901790
 
Description Roncador lab 
Organisation Spanish National Cancer Research Center
Country Spain 
Sector Public 
PI Contribution We generated a set of fusion proteins to the activated form of the transcription factor XBP1s. We evaluated the specificity of the resulting monoclonal antibodies by IHC and WB. I contributed extensively to the writing of the resulting manuscript.
Collaborator Contribution Generation and access to a unique set of monoclonal antibodies.
Impact 19176362
Start Year 2006
 
Description Surani Lab 
Organisation University of Cambridge
Department Gurdon Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution We provided access to a unique antibody to BLIMP1 and to unpublished data regarding target genes, we validated the promoter of a specific target gene as a direct target of BLIMP1 which constituted a supplemental figure in the paper.
Impact 18953407
Start Year 2006