Genomic analysis of the CD8 functional deficits associated with failure to control hepatitis B and hepatit

Lead Research Organisation: University College London
Department Name: Immunology and Molecular Pathology

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

10 25 50
 
Description MRC New Investigator Grant
Amount £315,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2006 
End 12/2009
 
Description MRC Project Grant
Amount £650,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2009 
End 04/2012
 
Description UCLH Clinical Research and Development Committee
Amount £30,000 (GBP)
Organisation University College London Hospitals NHS Foundation Trust 
Sector Public
Country United Kingdom
Start 04/2008 
End 10/2008
 
Description Genomic analysis of T cells in HBV 
Organisation University College London
Department Division of Infection and Immunity
Country United Kingdom 
Sector Academic/University 
PI Contribution Identification and purification of virus-specific Cd8 T cells. Expertise in the analysis of immune responses in chronic viral infections.
Collaborator Contribution Expert advice on the gene expression analysis of virus-specific T cells, including bioinformatics assistance with data analysis
Impact Lopes et al, JCI 2008 (publication list) International conference presentations
 
Description Role of NK cells in HBV-related liver damage 
Organisation University of Birmingham
Department College of Medical and Dental Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Led research into novel mechanism of immune-mediated liver damage in HBV infection
Collaborator Contribution Provision of valuable clinical samples and expertise in immunohistochemistry
Impact Dunn et al JEM 2007
 
Description T cell exhaustion 
Organisation University College London
Department Division of Infection and Immunity
Country United Kingdom 
Sector Academic/University 
PI Contribution Led the research into mechanims of exhaustion of T cells in HBV
Collaborator Contribution Expertise in the assessment of T cell senescence
Impact Das et al, JEM 2008
 
Title Use of a TRAIL-blocking monoclonal antibody to reduce toxicity of interferon-alpha treatment of chronic hepatitis B virus infection 
Description TRAIL and IL-8 can contribute to death of hepatocytes in HBV infection and bocking these may limit the toxicity of IFN-a therapy. 
IP Reference US2010040632 
Protection Patent granted
Year Protection Granted 2010
Licensed Yes
Impact Other groups in the field of viral hepatitis have started examining the role of NK cells and the TRAIL pathway.
 
Description Patient feedback sheet 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Participants in your research and patient groups
Results and Impact Information sheet on findings of research for patients who have participated by donating blood for the study

Patients were happy to continue to participate in the study.
Year(s) Of Engagement Activity 2006,2007
 
Description Primary school visit to institute 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Primary Audience Schools
Results and Impact Introducing primary school children to viral immunology on their visits to our institute with the help of an MRC Educator/artist.

Sessions very positively received and plan is to extend to other schools
Year(s) Of Engagement Activity 2008