Genomic analysis of the CD8 functional deficits associated with failure to control hepatitis B and hepatit

Lead Research Organisation: University College London
Department Name: Immunology and Molecular Pathology

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

10 25 50
 
Description Basic Science Interview Committee Member for the Wellcome Trust
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Through this membership, Mala Maini contributes to the decision-making process of selecting and deciding the most promising people and projects to receive funding for further development of skills and ideas that have the potential to make a difference.
 
Description Elected panel member of the International HBV Scientific Advisory Council
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact The goal of the committee is to increase and support research, education and patient advocacy to improve the quality of life and life expectancy of people living with chronic hepatitis.
 
Description Elected to the Governing Board of the "International Coalition to Eliminate HBV"
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact Mala Maini was elected to the Governing Board of the "International Coalition to Eliminate HBV". The coalition aims to bring together experts in the field to accelerate the discovery of a cure from chronic hepatitis B. They are dedicated to identifying gaps in knowledge and identifying new strategies and tools that are promising.
 
Description Medical Research Club: Elected member
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description MRC New Investigator Grant
Amount £315,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2006 
End 12/2009
 
Description MRC Project Grant
Amount £650,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2009 
End 04/2012
 
Description Genomic analysis of T cells in HBV 
Organisation University College London
Department Division of Infection and Immunity
Country United Kingdom 
Sector Academic/University 
PI Contribution Identification and purification of virus-specific Cd8 T cells. Expertise in the analysis of immune responses in chronic viral infections.
Collaborator Contribution Expert advice on the gene expression analysis of virus-specific T cells, including bioinformatics assistance with data analysis
Impact Lopes et al, JCI 2008 (publication list) International conference presentations
 
Description Role of NK cells in HBV-related liver damage 
Organisation University of Birmingham
Department College of Medical and Dental Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Led research into novel mechanism of immune-mediated liver damage in HBV infection
Collaborator Contribution Provision of valuable clinical samples and expertise in immunohistochemistry
Impact Dunn et al JEM 2007
 
Description T cell exhaustion 
Organisation University College London
Department Division of Infection and Immunity
Country United Kingdom 
Sector Academic/University 
PI Contribution Led the research into mechanims of exhaustion of T cells in HBV
Collaborator Contribution Expertise in the assessment of T cell senescence
Impact Das et al, JEM 2008
 
Title Use of a TRAIL-blocking monoclonal antibody to reduce toxicity of interferon-alpha treatment of chronic hepatitis B virus infection 
Description TRAIL and IL-8 can contribute to death of hepatocytes in HBV infection and bocking these may limit the toxicity of IFN-a therapy. 
IP Reference US2010040632 
Protection Patent granted
Year Protection Granted 2010
Licensed Yes
Impact Other groups in the field of viral hepatitis have started examining the role of NK cells and the TRAIL pathway.
 
Description Invited speaker at the Blumberg institute USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other audiences
Results and Impact Mala Maini was an invited speaker at the Blumberg institute USA (Virtual) talking about "Immunobiology of HBV". This presentaiton opens up discussion and collaborations with other teams and expands the reach of the research carried out in the laboratory.
Year(s) Of Engagement Activity 2020
 
Description Invited talk at Swiss Autoimmune Liver disease meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Mala Maini was invited to give a talk at Swiss Autoimmune Liver disease meeting Virtual Nov 2020: "Living in the liver". Great opportunity for furthering discussions and possible collaborations with other people in the field.
Year(s) Of Engagement Activity 2020
 
Description Patient feedback sheet 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Participants in your research and patient groups
Results and Impact Information sheet on findings of research for patients who have participated by donating blood for the study

Patients were happy to continue to participate in the study.
Year(s) Of Engagement Activity 2006,2007
 
Description Primary school visit to institute 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Primary Audience Schools
Results and Impact Introducing primary school children to viral immunology on their visits to our institute with the help of an MRC Educator/artist.

Sessions very positively received and plan is to extend to other schools
Year(s) Of Engagement Activity 2008