Do steroid transporters regulate the effects of glucocorticoid hormones on the brain - in cells, in animals and humans?
Lead Research Organisation:
King's College London
Department Name: Unlisted
Abstract
Major depression is the most prevalent of all psychiatric disorders and the single most burdensome disease in the world among people in the middle years of life. Moreover, currently available antidepressant treatments are effective in only 50-70 % of patients, and research into antidepressants has not yet identified a definitive biochemical system that is responsible for the clinical effects of these drugs. Recent studies have suggested that one possible biological mechanism involved in depression is the abnormal effect of glucocorticoid hormones, like cortisol, on the brain. Moreover, our own research has shown that antidepressant treatment may regulate the effects of cortisol on the brain.
The aim of this study is to examine, both in the laboratory and in a clinical setting, the physiology of the glucocorticoid action on the brain and the mechanisms behind its regulation by antidepressants. Therefore, this project will improve our knowledge of the causes of major depression and will lead to the development of new ideas for a better treatment, which will be the ultimate implementation of our research findings into clinical practice.
The aim of this study is to examine, both in the laboratory and in a clinical setting, the physiology of the glucocorticoid action on the brain and the mechanisms behind its regulation by antidepressants. Therefore, this project will improve our knowledge of the causes of major depression and will lead to the development of new ideas for a better treatment, which will be the ultimate implementation of our research findings into clinical practice.
Technical Summary
My hypothesis is that membrane steroid transporters, on the blood-brain-barrier (BBB) and in neurones, regulate the effects of the glucocorticoids on brain function and are a target of antidepressant treatment.
My recent work has demonstrated that membrane steroid transporters, like the multidrug resistance (MDR) P-glycoprotein (Pgp), regulate the intracellular levels of glucocorticoids in fibroblasts and neurones. Moreover, I have shown that the transport of glucocorticoids across cell membranes in vitro, and across the BBB in guinea-pigs, occurs at physiological concentrations of hormones. Finally, I have found that antidepressants inhibit these transporters (Pariante et al. 2001a, 2001b, 2003a; 2003b, 2004).
In the course of this 5-year project, I will study the membrane transport of glucocorticoids and its inhibition by antidepressants.
In vitro: I will study the mechanisms of steroid membrane transport, and of its inhibition by antidepressants, using techniques assessing the function and the expression of these transporters in mouse fibroblasts, rat cortical neurones, and epithelial cells that have been used as in vitro models of the human BBB.
In animals: I will study the transport of cortisol and corticosterone into the brain and cerebrospinal fluid (CSF) of mice (FBV mice that are knockout for MDR1a and MDR1b Pgp genes, and FVB/Ntac control mice). Moreover, I will examine the effects of 21-day treatment with the antidepressants, clomipramine and citalopram, on the transport of glucocorticoids.
In humans: I will investigate the access of cortisol and corticosterone to the brain, and its regulation by citalopram, in healthy volunteers, using a cognitive task (executive function) together with event-related potential (ERP) recordings.
The in vitro work (at the Institute of Psychiatry) will be conducted with Professor R. Kerwin, Dr A. Makoff and Professor S. Lovestone. The animal experiments will take place in the laboratories of Dr S. Thomas, at Guy‘s, King‘s and St Thomas‘ School of Biosciences, and of Professor S. Lightman and Dr H. Reul, in the Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology at the University of Bristol. The research in humans will be conducted at the University of Newcastle, with Dr H. McAllister-Williams. Conclusions:
My recent work has demonstrated that membrane steroid transporters, like the multidrug resistance (MDR) P-glycoprotein (Pgp), regulate the intracellular levels of glucocorticoids in fibroblasts and neurones. Moreover, I have shown that the transport of glucocorticoids across cell membranes in vitro, and across the BBB in guinea-pigs, occurs at physiological concentrations of hormones. Finally, I have found that antidepressants inhibit these transporters (Pariante et al. 2001a, 2001b, 2003a; 2003b, 2004).
In the course of this 5-year project, I will study the membrane transport of glucocorticoids and its inhibition by antidepressants.
In vitro: I will study the mechanisms of steroid membrane transport, and of its inhibition by antidepressants, using techniques assessing the function and the expression of these transporters in mouse fibroblasts, rat cortical neurones, and epithelial cells that have been used as in vitro models of the human BBB.
In animals: I will study the transport of cortisol and corticosterone into the brain and cerebrospinal fluid (CSF) of mice (FBV mice that are knockout for MDR1a and MDR1b Pgp genes, and FVB/Ntac control mice). Moreover, I will examine the effects of 21-day treatment with the antidepressants, clomipramine and citalopram, on the transport of glucocorticoids.
In humans: I will investigate the access of cortisol and corticosterone to the brain, and its regulation by citalopram, in healthy volunteers, using a cognitive task (executive function) together with event-related potential (ERP) recordings.
The in vitro work (at the Institute of Psychiatry) will be conducted with Professor R. Kerwin, Dr A. Makoff and Professor S. Lovestone. The animal experiments will take place in the laboratories of Dr S. Thomas, at Guy‘s, King‘s and St Thomas‘ School of Biosciences, and of Professor S. Lightman and Dr H. Reul, in the Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology at the University of Bristol. The research in humans will be conducted at the University of Newcastle, with Dr H. McAllister-Williams. Conclusions:
Organisations
- King's College London, United Kingdom (Collaboration, Fellow, Lead Research Organisation)
- University College London, United Kingdom (Collaboration)
- University of Edinburgh, United Kingdom (Collaboration)
- China Medical University Hospital (Collaboration)
- University of Bristol, United Kingdom (Collaboration)
- GlaxoSmithKline (GSK) (Collaboration)
- Erasmus University Rotterdam (EUR) (Collaboration)
- Newcastle University, United Kingdom (Collaboration)
- European College of Neuropsychopharmacology (ECNP) (Collaboration)
- Medical Research Council (Collaboration)
- Vall d'Hebron University Hospital (Collaboration)
- Guy's and St Thomas' NHS Foundation Trust, London (Collaboration)
- Johnson & Johnson Ltd, United Kingdom (Collaboration)
- Royal College of Surgeons in Ireland, Ireland (Collaboration)
- Pfizer Ltd (Collaboration)
- Wellcome Trust, LONDON (Collaboration)
- H. Lundbeck A/S (Collaboration)
- University of Barcelona, Spain (Collaboration)
People |
ORCID iD |
Carmine M. Pariante (Principal Investigator / Fellow) |
Publications

Hepgul N
(2010)
Psychological and biological mechanisms of cytokine induced depression.
in Epidemiologia e psichiatria sociale

Juruena MF
(2010)
The prednisolone suppression test in depression: dose-response and changes with antidepressant treatment.
in Psychoneuroendocrinology

Pawlby S
(2010)
Mind-mindedness and maternal responsiveness in infant-mother interactions in mothers with severe mental illness.
in Psychological medicine

Su KP
(2010)
Phospholipase A2 and cyclooxygenase 2 genes influence the risk of interferon-alpha-induced depression by regulating polyunsaturated fatty acids levels.
in Biological psychiatry

Mondelli V
(2010)
Adding aspirin to antipsychotics reduces psychopathology in adults with schizophrenia spectrum disorders
in Evidence-Based Mental Health


Mondelli V
(2010)
Adding aspirin to antipsychotics reduces psychopathology in adults with schizophrenia spectrum disorders.
in Evidence-based mental health

Mondelli V
(2010)
Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis.
in Schizophrenia research

Sugden K
(2010)
Housekeeping gene expression is affected by antidepressant treatment in a mouse fibroblast cell line.
in Journal of psychopharmacology (Oxford, England)

Ouellet-Morin I
(2011)
A discordant monozygotic twin design shows blunted cortisol reactivity among bullied children.
in Journal of the American Academy of Child and Adolescent Psychiatry
Title | For all sad words |
Description | Developed in collaboration with Prof Carmine Pariante, this work is a metaphorical blood exchange. It draws from Prof Pariante's research at King's College on blood inflammation in patients with depression, Stanford University's studies that show transfusion of young blood in old mice reversed aging, and Lund University's proposition that a protein found in beetroot (incidentally an anti-inflammatory food) could substitute human blood. The artist, Lynn Lu, invited participants to tell her about a significant personal regret. Then she pricked their finger and place a drop of blood in a petri dish. In exchange, she offers them a shot of anti-inflammatory beet juice. Over the weekend, the petri dishes fill with blood "inflamed" with lament, while vials of detoxifying beetroot empty one by one. |
Type Of Art | Performance (Music, Dance, Drama, etc) |
Year Produced | 2017 |
Impact | Engagement with the Science Gallery and other artistic organisation interested in using art to disseminate science |
URL | https://lynnlu.info/for-of-all-sad-words-of-tongue-and-pen-the-saddest-are-these-it-might-have-been/... |
Title | Recording for live performance of artist Lynn Lu |
Description | Drawing deeply from her personal experience, the artist Lynn Lu has spent some time during the development process of a performance for the CCLAP Festival with Professor Carmine Pariante, and his team at King's College London. Their research has found a clear link between mothers with postnatal depression not adequately nurturing their children and these children in time becoming themselves mothers who suffer from postnatal depression. At Deptford Lounge, the artist will create a safe space, one that she would have liked to have had, as a mother with postnatal depression. This safe space is offered to all mothers, as well as for anyone who might need an experience of nurturing. Together the artist and participants will put in words their darkest thoughts and feelings that have not been voiced. The anonymous texts will then be sealed in palm-sized clay envelops, and fired for strength / privacy / resilience. These accumulating tablets will be exhibited throughout the week. Participants will be invited to be cocooned and rocked in a wide fabric hammock for as long as they wish - as if in the womb, or a rockabye baby. In doing so, they will listen to a RECORDING OF THE INTERVIEW BETWEEN PROFESSOR PARIANTE AND THE ARTIST, which has been digitally modified so to make the words unintelligeble and similar to relaxing music. This performance will take place at Deptford Lounge. Full schedule for CCLAP 2015. |
Type Of Art | Performance (Music, Dance, Drama, etc) |
Year Produced | 2015 |
Impact | The recording was used in the performance, as above, so was publicly used. |
URL | http://cclap.me/2015/10/26/cclap-2015-lynn-lu-the-hand-that-rocks-the-cradle/ |
Title | The London Riots, a Psychiatrist's Perspective |
Description | A blog on the 2012 London Riots. In 2012, one year after the London riots, I wrote a blog for the Huffington Post UK, and longer academic paper, where I tried to interpret the terrible events of 2011 London's burning through a psychosocial perspective. As you will read in the blog, republished below, I lamented that, one year on at that time, there had been no attempt to understand the youth's suffering that had led to the protest, and that all the events were brushed under the carpet as a public order problem. Unfortunately, 10 years on and the situation has not changed: lessons have still not been learned, and there is a clear concern that the same factors operating then can make the same events happen again today. |
Type Of Art | Creative Writing |
Year Produced | 2021 |
Impact | Impact on the knowledge of the public |
URL | https://www.inspirethemind.org/blog/the-london-riots-a-psychiatrists-perspective?rq=pariante |
Description | 2013 CMO Report on Mental Health - Chapter on Neuroscience |
Geographic Reach | National |
Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
Impact | Improved understanding of neuroscience issues relevant to mental health |
Description | BAP Antidepressant Guideliness |
Geographic Reach | National |
Policy Influence Type | Membership of a guidance committee |
Impact | Improvement of prescription practice |
Description | British Association for Psychopharmacology consensus guidance on the use of psychotropic medication preconception, in pregnancy and postpartum 2017. |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Membership of a guideline committee |
Impact | Decisions about the use of psychotropic medication in pregnancy are an ongoing challenge for clinicians and women with mental health problems, owing to the uncertainties around risks of the illness itself to mother and fetus/infant, effectiveness of medications in pregnancy and risks to the fetus/infant from in utero exposure or via breast milk. These consensus guidelines aim to provide pragmatic advice regarding these issues. They are divided into sections on risks of untreated illness in pregnancy; general principles of using drugs in the perinatal period; benefits and harms associated with individual drugs; and recommendations for the management of specific disorders. |
URL | http://journals.sagepub.com/doi/pdf/10.1177/0269881117699361 |
Description | Lead of a new consensus statement on treatment resistant depression |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Membership of a guideline committee |
Description | Member of the Strategic Advisory Board of the Wellcome Trust Mental Health Programme |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Participation in a advisory committee |
URL | https://wellcome.org/about-us/teams/mental-health-programme-team |
Description | AMBROSIAC - A Menu for Brain Responses Opposing Stress-Induced Alterations in Cognition |
Amount | £169,306 (GBP) |
Funding ID | MR/N029488/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 05/2016 |
End | 08/2018 |
Description | APIRE award |
Amount | £24,000 (GBP) |
Organisation | American Psychiatric Institute for Research and Education |
Sector | Charity/Non Profit |
Country | United States |
Start | 01/2007 |
End | 01/2009 |
Description | BA Project Grant |
Amount | £100,000 (GBP) |
Organisation | The British Academy |
Sector | Academic/University |
Country | United Kingdom |
Start | 01/2007 |
End | 01/2010 |
Description | Biomedical Research Centre - Affective Disorder and Interface with Medicine Theme |
Amount | £50,000,000 (GBP) |
Funding ID | NIHR Biomedical Research Centre at the South London and Maudsley NHS Trust and King's College London |
Organisation | National Institute for Health Research |
Department | NIHR Biomedical Research Centre |
Sector | Public |
Country | United Kingdom |
Start | 03/2017 |
End | 03/2022 |
Description | Causative mechanisms & integrative models linking early-life-stress to psycho-cardio-metabolic multi-morbidity EC - European Commission |
Amount | € 6,000,000 (EUR) |
Funding ID | Earlycause |
Organisation | European Commission H2020 |
Sector | Public |
Country | Belgium |
Start | 12/2019 |
End | 12/2023 |
Description | Distinguished Investigator Award |
Amount | $100,000 (USD) |
Organisation | Brain & Behaviour Research Foundation |
Sector | Charity/Non Profit |
Country | United States |
Start | 06/2018 |
End | 06/2019 |
Description | Do steroid transporters regulate the effects of glucocorticoid hormones on the brain - in cells, in animals and humans? |
Amount | £866,288 (GBP) |
Funding ID | G108/603 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 05/2004 |
End | 12/2009 |
Description | Does COVID-19 affect the brain?(JBCF) |
Amount | £25,000 (GBP) |
Funding ID | M970 |
Organisation | Rosetrees Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 02/2021 |
End | 02/2022 |
Description | EC FP7 Collaborative Project Grant (Agreement n°22963 (Mood Inflame)) |
Amount | £484,000 (GBP) |
Organisation | European Commission |
Department | Seventh Framework Programme (FP7) |
Sector | Public |
Country | European Union (EU) |
Start | 01/2008 |
End | 01/2012 |
Description | ECNP Young Researcher Grant/European College of Neuropsychopharmacology (ECNP) Studenstships |
Amount | £80,000 (GBP) |
Organisation | European College of Neuropsychopharmacology (ECNP) |
Sector | Charity/Non Profit |
Country | Netherlands |
Start | 01/2009 |
End | 01/2011 |
Description | EU Patient-cEntric clinicAl tRial pLatforms |
Amount | € 12,000,000 (EUR) |
Organisation | European Commission H2020 |
Sector | Public |
Country | Belgium |
Start | 11/2019 |
End | 04/2023 |
Description | FSID Project Grant |
Amount | £50,000 (GBP) |
Organisation | The Lullaby Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2010 |
End | 01/2011 |
Description | Jannsen Investigator Initiated |
Amount | £680,000 (GBP) |
Organisation | Johnson & Johnson |
Department | Janssen Pharmaceuticals |
Sector | Private |
Country | United States |
Start | 01/2013 |
End | 12/2017 |
Description | King's College Development Trust Studentship |
Amount | £63,000 (GBP) |
Organisation | King's College London |
Sector | Academic/University |
Country | United Kingdom |
Start | 01/2006 |
End | 01/2009 |
Description | MRC Immunopsychiatry consortium |
Amount | £200,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2014 |
End | 09/2016 |
Description | MRC Research Grant (Eurostress) |
Amount | £66,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2009 |
End | 01/2012 |
Description | Marie Curie |
Amount | £180,000 (GBP) |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 03/2013 |
End | 03/2015 |
Description | NARSAD Young and Intermediate Investigator Awards |
Amount | £310,000 (GBP) |
Organisation | Autism Speaks |
Sector | Charity/Non Profit |
Country | United States |
Start | 01/2006 |
End | 01/2011 |
Description | NIHR Senior Investigator |
Amount | £45,000 (GBP) |
Funding ID | NF-SI-0616-10074 |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 03/2017 |
End | 03/2020 |
Description | Persistent Fatigue Induced by Interferon-alpha: A New Immunological Model for Chronic Fatigue Syndrome |
Amount | £373,075 (GBP) |
Funding ID | MR/J002739/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 07/2012 |
End | 08/2016 |
Description | Post-doctorate fellowship to Martin Egeland to study inflammation and neurogenesis in rodents |
Amount | £182,000 (GBP) |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 04/2013 |
End | 04/2015 |
Description | Professor, Carmine M. Pariante |
Amount | £100,000 (GBP) |
Funding ID | NIHR201376 |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 03/2020 |
End | 03/2025 |
Description | Scaling-up Health-Arts Programmes: Implementation and Effectiveness Research (SHAPER) |
Amount | £1,999,998 (GBP) |
Funding ID | 219425/Z/19/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2019 |
End | 09/2022 |
Description | South London and Maudsley NHS Foundation Trust & Institute of Psychiatry NIHR Biomedical Research Centre for Mental Health |
Amount | £250,000 (GBP) |
Organisation | South London and Maudsley (SLAM) NHS Foundation Trust |
Department | NIHR Maudsley Biomedical Research Centre |
Sector | Academic/University |
Country | United Kingdom |
Start | 01/2007 |
End | 01/2012 |
Description | The Impact of Early Adversity on Trajectories of Brain Maturation and Mental Health in Young Adolescents |
Amount | £100,144 (GBP) |
Funding ID | MR/S003444/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2018 |
End | 09/2022 |
Description | To investigate inflammation-related cellular models of depression |
Amount | £680,000 (GBP) |
Organisation | Johnson & Johnson |
Department | Janssen Pharmaceutica |
Sector | Private |
Country | Global |
Start | 11/2013 |
End | 12/2016 |
Description | Understanding the role of gender, inflammation and sex hormones in the prevention and treatment of affective disorders Psychiatry Research Trust |
Amount | £83,444 (GBP) |
Funding ID | Psychiatry Research Trust |
Organisation | King's College London |
Department | Psychiatry Research Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2018 |
End | 09/2021 |
Description | WHAT ARE THE IMMUNE SYSTEM RISK FACTORS FOR DEVELOPING CHRONIC POST-VIRAL FATIGUE FOLLOWING SARS-COV |
Amount | £99,998 (GBP) |
Funding ID | KENN192010 |
Organisation | The Kennedy Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 04/2020 |
End | 11/2021 |
Description | Wellcome Project grant |
Amount | £447,000 (GBP) |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2009 |
End | 01/2013 |
Description | Wellcome Trust Neuroimmunology Consortium |
Amount | £1,100,000 (GBP) |
Organisation | Wellcome Trust |
Department | Wellcome Trust Institutional Strategic Support Fund |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2015 |
End | 12/2019 |
Title | Depression in a dish model |
Description | We have used human neuronal stem cells and human neurones derived from iPSC cells and treated with a host of depressogenic stimuli (cortisol, Il-1, Il-6, interferon-alpha, oxidative stress) and antidepressant strategies (SSRIs, tricyclics, omega-3, anti-inflammatories). This model replicates well established brain cellular phenotypes associated with depression (or, conversely, antidepressant treatment) such as change sin neurogenesis and synaptogenesis, as well as changes in molecular mechanisms that can be replicated in the brain of animal subjected to stress/antidepressants as well as in clinical samples of depressed patients. 1: Egeland M, Zunszain PA, Pariante CM. Molecular mechanisms in the regulation of adult neurogenesis during stress. Nat Rev Neurosci. 2015 Apr;16(4):189-200. doi: 10.1038/nrn3855. Review. PubMed PMID: 25790864. 2: Horowitz MA, Wertz J, Zhu D, Cattaneo A, Musaelyan K, Nikkheslat N, Thuret S, Pariante CM, Zunszain PA. Antidepressant compounds can be both pro- and anti-inflammatory in human hippocampal cells. Int J Neuropsychopharmacol. 2014 Oct 31;18(3). pii: pyu076. doi: 10.1093/ijnp/pyu076. PubMed PMID: 25522414; PubMed Central PMCID: PMC4360247. 3: Anacker C, Cattaneo A, Musaelyan K, Zunszain PA, Horowitz M, Molteni R, Luoni A, Calabrese F, Tansey K, Gennarelli M, Thuret S, Price J, Uher R, Riva MA, Pariante CM. Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8708-13. doi: 10.1073/pnas.1300886110. Epub 2013 May 6. PubMed PMID: 23650397; PubMed Central PMCID: PMC3666742. 4: Anacker C, Cattaneo A, Luoni A, Musaelyan K, Zunszain PA, Milanesi E, Rybka J, Berry A, Cirulli F, Thuret S, Price J, Riva MA, Gennarelli M, Pariante CM. Glucocorticoid-related molecular signaling pathways regulating hippocampal neurogenesis. Neuropsychopharmacology. 2013 Apr;38(5):872-83. doi: 10.1038/npp.2012.253. Epub 2012 Dec 6. PubMed PMID: 23303060; PubMed Central PMCID: PMC3672002. 5: Zunszain PA, Anacker C, Cattaneo A, Choudhury S, Musaelyan K, Myint AM, Thuret S, Price J, Pariante CM. Interleukin-1ß: a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis. Neuropsychopharmacology. 2012 Mar;37(4):939-49. doi: 10.1038/npp.2011.277. Epub 2011 Nov 9. PubMed PMID: 22071871; PubMed Central PMCID: PMC3280640. 6: Anacker C, Zunszain PA, Cattaneo A, Carvalho LA, Garabedian MJ, Thuret S, Price J, Pariante CM. Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor. Mol Psychiatry. 2011 Jul;16(7):738-50. doi: 10.1038/mp.2011.26. Epub 2011 Apr 12. PubMed PMID: 21483429; PubMed Central PMCID: PMC3121947. |
Type Of Material | Model of mechanisms or symptoms - in vitro |
Year Produced | 2015 |
Provided To Others? | Yes |
Impact | Development of a platform for the potential development of novel antidepressants, with reduction in required use of animals. |
URL | http://www.pnas.org/content/110/21/8708.long |
Description | Covid research network |
Organisation | Guy's and St Thomas' NHS Foundation Trust |
Country | United Kingdom |
Sector | Public |
PI Contribution | We are leading a consortium of scientists interested in the molecular mechanisms underpinning the effects of COVID on the brain |
Collaborator Contribution | We have led our first submitted publication and our first grant submission |
Impact | 1) For submission to Molecular Psychiatry Neurogenesis is disrupted in human hippocampal progenitor cells upon exposure to serum samples from hospitalized COVID-19 patients with neurological symptoms Alessandra Borsini, PhD1*, Blair Merrick, MD2, Jonathan Edgeworth, PhD, MD3, Deepak Srivastava, PhD4,5, Anthony C. Vernon, PhD4,5, Gaia Nebbia, PhD, MD3, Sandrine Thuret, PhD4, Carmine M. Pariante, PhD, MD1 1 Stress, Psychiatry and Immunology Laboratory, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, King's College London, UK 2 Centre for Clinical Infection and Diagnostics Research, Guy's and St Thomas' NHS Foundation Trust, London, UK 3 School of Immunology and Microbial Sciences, Guy's and St Thomas' NHS Foundation Trust, London, UK 4 Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK 5MRC Centre for Neurodevelopmental Disorders, King's College London, UK 2) King's Together: Round 10 - Support for re-starting research and research careers post-COVID (NOT FUNDED): Gaining mechanistic insight "in vitro" on how hippocampal brain cells function isare disrupted upon exposure to serum from long-COVID-19 patients with neurological manifestations (neuro long-COVID-19) Role in project Name Faculty Department Position Joint Principal Investigator Carmine M. Pariante (F) Psychiatry, Psychology and Neuroscience Psychological Medicine Academic (Professor) Joint Principal Investigator Alessandra Borsini Psychiatry, Psychology and Neuroscience Psychological Medicine PDRA Joint Principal Investigator Tom Pollak Psychiatry, Psychology and Neuroscience Psychosis Studies Academic (Lecturer) Joint Principal Investigator Leonie Taams Life Sciences & Medicine Immunology, Infection & Inflammatory Disease Academic (Professor) Joint Principal Investigator Clare Brant Arts & Humanities English Language & Literature Academic (Professor) Joint Principal Investigator Anna Reading Arts & Humanities Culture, Media & Creative Industries Academic (Professor) CoI Sandrine Thuret Neuroscience Basic and Clinical Neuroscience Academic (Reader) CoI Tony Vernon Neuroscience Basic and Clinical Neuroscience Academic (Senior Lecturer) CoI Deepak Srivastava Neuroscience Basic and Clinical Neuroscience Academic (Reader) CoI Tim Nicolson Psychiatry, Psychology and Neuroscience Psychosis Studies Academic (Lecturer) CoI Ester Coutinho Neuroscience Clinical and Basic Neurosciences Research Fellow CoI Francesca Capon Life Sciences & Medicine Medical & Molecular Genetics Academic (Reader) CoI Beatrice Pembroke KCL Culture Team Not applicable Executive Director CoI Johanna Kieniewicz KCL Culture Team Not applicable Head of Education and Research Collaborations 3) - Rosetrees Trust - Borsini (PI) 01/02/2021-31/01/2022 £25,000 Effects of COVID-19 on the brain and gaining mechanistic insight "in vitro" - 1 hour/week |
Start Year | 2021 |
Description | Department of Psychiatry and Mind-Body Interface Research Centre, China Medical University Hospital, Taichung, Taiwan |
Organisation | China Medical University Hospital |
Department | Department of Psychiatry and Mind-Body Interface Research Centre |
Country | Taiwan, Province of China |
Sector | Hospitals |
PI Contribution | Exchange visit between Dr. Su (Taiwan) and Dr. Pariante |
Collaborator Contribution | Research collaboration with Dr. Su |
Impact | Many publications have arisen from this collaboration, built on work conducted both in London and in Taiwan: PMID: 18370571; 17888811; 17591516; 17503999; 17070845; 17017838; 20034614. |
Start Year | 2006 |
Description | Department of Psychiatry, Newcastle University, UK |
Organisation | Newcastle University |
Department | Academic Psychiatry and Regional Affective Disorders Service |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | A study was conducted on EEG and cortisol in the collaborator's laboratory; the study was funded by this grant and was in the original research proposal. |
Collaborator Contribution | Collaboration with Dr. H. McAllister-Williams for a clinical study on EEG. |
Impact | The study has been completed and a publication is currently in preparation. |
Start Year | 2008 |
Description | EU EARLYSTART |
Organisation | University of Barcelona |
Country | Spain |
Sector | Academic/University |
PI Contribution | Karim Lekadir, PhD, is the Director of the Artificial Intelligence in Medicine Lab at the Universitat de Barcelona, and is the coordinator for the EU consortium EarlyCause H2020 project. I am the workpackage leader for the celular component, but the overal consortium aims to study the causative mechanisms linking early-life-stress to psycho-cardio-metabolic multi-morbidity |
Collaborator Contribution | Dr Kadir has led the application phase and contonue to succesfully lead the programme |
Impact | EU EARLYSTART 06/12/2019-05/12/2023 £391,175 research grant to KCL, Euro6M to the whole consortium |
Start Year | 2018 |
Description | EU IMI EU-PEARL |
Organisation | Vall d'Hebron University Hospital |
Country | Spain |
Sector | Hospitals |
PI Contribution | I am WP leader for depression for a IMI application led by Vall d'Hebron University Hospital. The overal IMI application is dedicated to set up a European platform for clinical trials. |
Collaborator Contribution | Vall d'Hebron University Hospital has offered scientific and management leadership both during the application phase and now during the grant |
Impact | - EU IMI EU-PEARL 01/10/2019-30/09/2024 £514,145 to KCL (Euro 12M to the consortium) |
Start Year | 2018 |
Description | Erasmus University, Rotterdam |
Organisation | Erasmus University Rotterdam |
Country | Netherlands |
Sector | Academic/University |
PI Contribution | Exchange of researchers and data |
Collaborator Contribution | Training in laboratory expertise and exchange of data |
Impact | Papers and new grant applications. |
Start Year | 2008 |
Description | Immuno-NeuroPsychiatry Thematic Working Group |
Organisation | European College of Neuropsychopharmacology (ECNP) |
Country | Netherlands |
Sector | Charity/Non Profit |
PI Contribution | The TWG on "Immuno-NeuroPsychiatry" comprise internationally recognized clinical centers particularly helpful for the development of data bases, pathophysiological and therapeutic studies in humans. They will be completed by the implementation of research groups using laboratory animal models to perform high-level translational research projects, enabling to substantially improve mechanistic and functional knowledge about the exact nature of the relationships of inflammatory state with relevant clinical dimensions, treatment resistance and therefore promote appropriate pharmacological interventions. I am a senior member of this initiative, andmany members of my research group also are part of this. |
Collaborator Contribution | ECNP has led the process bringing the many scientist together and offered infrastructure support for the relevant publications, including dissemination and press support. |
Impact | De Picker LJ, Dias MC, Benros ME, Vai B, Branchi I, Benedetti F, Borsini A, Leza JC, Kärkkäinen H, Männikkö M, Pariante CM, Güngör ES, Szczegielniak A, Tamouza R, van der Markt A, Fusar-Poli P, Beezhold J, Leboyer M. Severe mental illness and European COVID-19 vaccination strategies. Lancet Psychiatry. 2021 Feb 17:S2215-0366(21)00046-8. doi: 10.1016/S2215-0366(21)00046-8. Epub ahead of print. Erratum in: Lancet Psychiatry. 2021 Feb 25;: PMID: 33609450; PMCID: PMC7906735. De Picker LJ, Yolken R, Benedetti F, Borsini A, Branchi I, Fusar-Poli P, Carlos Leza J, Pariante C, Pollak T, Tamouza R, Vai B, Vernon AC, Benros ME, Leboyer M; ECNP Immuno-NeuroPsychiatry TWG. Viewpoint | European COVID-19 exit strategy for people with severe mental disorders: Too little, but not yet too late. Brain Behav Immun. 2021 Jan 23:S0889-1591(21)00012-X. doi: 10.1016/j.bbi.2021.01.008. Epub ahead of print. PMID: 33493625. Branchi I, Poggini S, Capuron L, Benedetti F, Poletti S, Tamouza R, Drexhage HA, Penninx BWJH, Pariante CM; European College of Neuropsychopharmacology (ECNP) ImmunoNeuroPsychiatry Thematic Working Group and Marion Leboyer. Brain- immune crosstalk in the treatment of major depressive disorder. Eur Neuropsychopharmacol. 2020 Dec 29:S0924-977X(20)30968-8. doi: 10.1016/j.euroneuro.2020.11.016. Epub ahead of print. PMID: 33386229. |
Start Year | 2019 |
Description | Janssen Pharmaceuticals |
Organisation | Johnson & Johnson |
Department | Janssen Pharmaceuticals |
Country | United States |
Sector | Private |
PI Contribution | A joint academic-pharma collaboration that has brought approximately £680,000 in research funding |
Collaborator Contribution | Shared academic leadership and full funding of research programma |
Impact | - a fully funded research programme on depression and inflammation - additional grant applications to MRC and the Wellcome |
Start Year | 2012 |
Description | MRC Immunopsychiatry Consortium |
Organisation | GlaxoSmithKline (GSK) |
Department | Psychiatry (GSK) |
Country | United Kingdom |
Sector | Private |
PI Contribution | Design of studies, execution of studies and experiments |
Collaborator Contribution | Funding of studies, contribution to research strategy and design |
Impact | Data exchange, publications (in preparation) |
Start Year | 2014 |
Description | MRC Immunopsychiatry Consortium |
Organisation | Medical Research Council (MRC) |
Country | United Kingdom |
Sector | Public |
PI Contribution | Design of studies, execution of studies and experiments |
Collaborator Contribution | Funding of studies, contribution to research strategy and design |
Impact | Data exchange, publications (in preparation) |
Start Year | 2014 |
Description | MRC Social Genetic and Developmental Psychiatry Centre (SDGP |
Organisation | King's College London |
Department | MRC Social Genetic and Developmental Psychiatry Centre (SDGP) |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Collaboration with Dr. Aitchison and Professors Moffitt and Caspi. |
Collaborator Contribution | Development of a parallel clinical and pre-clinical research strategy linked with the current proposal. |
Impact | PMID 19751968, 19074533, 18458677, 19996051, 18391129, 17229839, 20157309 |
Start Year | 2006 |
Description | Pharmaceutical Science Research Division, Kings College London (KCL), UK |
Organisation | King's College London |
Department | School of Medicine KCL |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | The experiments on blood-brain barrier permeability have been conducted in the collaborator's laboratory but funded by this grant. |
Collaborator Contribution | Collaboration with Dr. Sarah Thomas in joint supervision of a PhD student and conducting animal studies. |
Impact | PMID: 18556350, 17356567, 20881247 |
Description | Queen's Medical Research Institute, University of Edinburgh, UK |
Organisation | University of Edinburgh |
Department | Queen's Medical Research Institute Edinburgh |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | I have been in Edinburgh several times to plan the experiments with the collaborators. The collaborators have funded and conducted the study |
Collaborator Contribution | Collaboration with Professor Seckl in an animal study |
Impact | PMID: 17356567 |
Start Year | 2006 |
Description | Royal College of Surgeons in Ireland |
Organisation | Royal College of Surgeons in Ireland |
Department | Department of Psychiatry |
Country | Ireland |
Sector | Academic/University |
PI Contribution | Scientific collaboration on in vitro models relevant to the present project |
Collaborator Contribution | Collaboration on in vitro models based on present grant |
Impact | PMID: 18562437, 17938637 |
Description | SHAPER |
Organisation | University College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | I am co-leading a research programme on art and mental health together with Daisy Fancourt (at UCL) |
Collaborator Contribution | Dr. Fancourt is co-leading with me and is offering both scientific and managerial leadership |
Impact | - Wellcome Trust SHAPER 01/10/2019-30/09/2022 £1,999,998 To Scale-up Health-Arts Programmes: Implementation and Effectiveness Research |
Start Year | 2019 |
Description | University of Bristol |
Organisation | University of Bristol |
Department | School of Clinical Sciences |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We have planned together animal and human research funded by this grant. |
Collaborator Contribution | Scientific collaboration with Professor Stafford Lightman |
Impact | PMID 19336786, 18675469, 17356567, 17016711, 20558006 |
Description | Wellcome Trust Neuroimmunology Consortium |
Organisation | H. Lundbeck A/S |
Department | Neuroscience; Lundbeck |
Country | Denmark |
Sector | Private |
PI Contribution | A research consortium; we recruit and select patients and deliver research |
Collaborator Contribution | They participate to the research strategy |
Impact | Data collection, publications (all still in preparation), novel potential targets for antidepressants discovery |
Start Year | 2014 |
Description | Wellcome Trust Neuroimmunology Consortium |
Organisation | Johnson & Johnson |
Country | United States |
Sector | Private |
PI Contribution | A research consortium; we recruit and select patients and deliver research |
Collaborator Contribution | They participate to the research strategy |
Impact | Data collection, publications (all still in preparation), novel potential targets for antidepressants discovery |
Start Year | 2014 |
Description | Wellcome Trust Neuroimmunology Consortium |
Organisation | Pfizer Ltd |
Country | United Kingdom |
Sector | Private |
PI Contribution | A research consortium; we recruit and select patients and deliver research |
Collaborator Contribution | They participate to the research strategy |
Impact | Data collection, publications (all still in preparation), novel potential targets for antidepressants discovery |
Start Year | 2014 |
Description | Wellcome Trust Neuroimmunology Consortium |
Organisation | Wellcome Trust |
Department | Wellcome Trust Strategic Award |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | A research consortium; we recruit and select patients and deliver research |
Collaborator Contribution | They participate to the research strategy |
Impact | Data collection, publications (all still in preparation), novel potential targets for antidepressants discovery |
Start Year | 2014 |
Title | Gene expression levels of inflammatory cytokines as predictor of antidepressant response |
Description | Validation in a second sample now completed; publication in submission |
Type | Diagnostic Tool - Non-Imaging |
Current Stage Of Development | Refinement. Clinical |
Year Development Stage Completed | 2016 |
Development Status | Under active development/distribution |
Impact | Improve prediction of antidepressant response and personalised medicine |
Title | Prednisolone suppression test |
Description | A test to assess stress hormones secretion that predicts treatment response in depressed patients. |
Type | Diagnostic Tool - Non-Imaging |
Current Stage Of Development | Early clinical assessment |
Year Development Stage Completed | 2010 |
Development Status | Under active development/distribution |
Impact | The relevant paper have been published: 19336786, 17016711, 20558006. |
Description | A follow-up interview after one year of pandemic, for the Science Weekly Guardian Podcast |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Ian Sample is joined again by Prof Carmine Pariante to discuss pandemic burnout and how to look after our mental health over the coming months |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.theguardian.com/science/audio/2021/mar/02/covid-19-why-are-we-feeling-burnt-out |
Description | Antidepressants may not be perfect, but they DO save lives: Expert reveals how life-changing the drug can be when used in the right way |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Professor Carmine Pariante has treated thousands of patients with depression Despite expert claims the pills have devastating side-effects, he stands by them They work when used correctly, especially alongside psychological therapy Read more: http://www.dailymail.co.uk/health/article-4243156/Antidepressants-not-perfect-save-lives.html#ixzz4awYvDP2Q |
Year(s) Of Engagement Activity | 2017 |
URL | http://www.dailymail.co.uk/health/article-4243156/Antidepressants-not-perfect-save-lives.html |
Description | Article for The Independent |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | An opinion piece defending the safe use of antidepressants. As a psychiatrist, I know that Johann Hari is wrong to cast doubt on antidepressants Suggesting that prescribing antidepressants to a patient who suffers from clinical depression is the equivalent of treating them as a 'machine with malfunctioning parts' is wrong, unhelpful and even dangerous Carmine Pariante Wednesday 10 January 2018 14:00 GMT |
Year(s) Of Engagement Activity | 2018 |
URL | http://www.independent.co.uk/voices/johann-hari-depression-anti-depressants-psychiatrists-pills-ther... |
Description | Blog on fathers' mental health |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Elliott Rae is the founder of Music.Football.Fatherhood (MFF), a successful blog platform where all aspects of fatherhood and masculinity, including mental health, are discussed openly by him and a number of guest writers. Building on this community of writers, earlier this year he published the book, DAD, which he co-wrote and curated along with 20 other fathers: an inspiring collection of stories that represent the diversity of modern fatherhood, exploring everything from childbirth trauma to surrogacy, from bereavement to gender stereotypes, from being a gay father to changing work-life balance, and more. Inspire the Mind Deputy Editor, Melissa Bujtor, read the book and was deeply moved by the raw honesty of the stories. She came to me with the idea of curating a series of blogs on fathers' mental health, match-making the compelling and inspiring stories of four writers with the scientific and medical perspectives of four academics. (See the Editor's note at the end of this blog for a snapshot of the programme). And she suggested I started the series with an interview of the man behind this adventure. I started my interview by asking why he, a committed and busy civil servant in the Department of Transport, started MFF. |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.inspirethemind.org/blog/reframing-fathers-mental-health-an-interview-with-elliott-rae-fo... |
Description | Blog on the Huffington Post |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | A regular blog entry that I have on the Huffington Post on topics of mental health |
Year(s) Of Engagement Activity | 2012,2015,2016,2017 |
URL | http://www.huffingtonpost.co.uk/author/carmine-pariante |
Description | CNN Interview on COVID |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Carmine Pariante, talks live on CNN with Victor Blackwell on "re-entry syndrome" after COVID. Broadcasted on18 June 2021, the interview discusses the anxiety that people might feel after the lockdown, when we are invited to go back of our offices and to socialise with our friends. And what can we all do about it - both as employers and employees. |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.youtube.com/watch?v=1HgXqHCXZe4 |
Description | Cheltenham Science festival |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | Yes |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Many questions and subsequent emails I was reached by journalists for further interviews |
Year(s) Of Engagement Activity | 2012 |
Description | Daily Mail |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Interview of perinatal depression Attracted public interest |
Year(s) Of Engagement Activity | 2010 |
Description | Inspire the Mind - a new online publication on mental health |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | InSPIre the Mind is new online publication directed by Carmine Pariante. It will bring the point of view of a group of clinicians and researchers working in mental health. In this new publication, we want to complement people's accounts by discussing the clinical and the scientific evidence underpinning these personal experiences, while also sharing with the readers our research, our clinical work, and or our cultural and societal considerations. We are the members of the Stress, Psychiatry and Immunology (SPI) Lab at the Institute of Psychiatry, Psychology and Neuroscience, at King' College London, and these are our stories. So far, the website has been visited more than 100,000 times |
Year(s) Of Engagement Activity | 2019,2020,2021 |
URL | http://www.inspirethemind.org |
Description | Inspire the Mind Instagram interviews |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Video interviews cnducted by journalist Rachel Kelly with some of the most important voices in mental health. |
Year(s) Of Engagement Activity | 2020,2021,2022 |
URL | https://www.inspirethemind.org/interviews |
Description | Interview for BBC Radio 4 Programme |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | BBC health reporter James Gallagher explores the increasing body of evidence that a dysfunctional immune system is responsible for the depression or psychotic illness experienced by hundreds of thousands, perhaps millions, of people in the UK. James talks to the psychiatrists investigating this new understanding of mental illness and to people who may benefit from treatments aimed at the immune systems rather than their brain cells. "I believe this is one of the strongest discoveries in psychiatry in the last twenty years", says Professor Carmine Pariante of his and other research on the immune system and depression. "It allows us to understand depression no longer as just a disorder of the mind and not even a disorder of the brain, but a disorder of the whole body. It shifts conceptually what we understand about depression." James also talks to New York journalist Susannah Cahalan. She began to experience paranoid delusions and florid hallucinations when her immune system made damaging antibodies against part of the molecular circuitry in her brain. Treatment to eliminate the antibodies prevented her committal to psychiatric hospital. Psychiatrist Professor Belinda Lennox at the University of Oxford says she has evidence that a significant proportion of people presenting for the first time with psychotic symptoms are victims of a similar autoimmune problem. Producer: Rachael Buchanan and Andrew Luck-Baker. |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.bbc.co.uk/programmes/b07pj2pw |
Description | Interview for The Guardian Science Weekly Podcast on the Impact of the pandemic on mental health |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | As the lockdown in the UK looks set to continue, Ian Sample speaks to Prof Carmine Pariante about the physiological and psychological effects of social isolation. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.theguardian.com/science/audio/2020/apr/15/covid-19-how-can-social-isolation-affect-us-po... |
Description | Interview on the Daily Mail on my research on CFS/ME |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Journalist Jo MacFarlane interviewed me on my research on CFS/ME and its relevance to Long Covid |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.dailymail.co.uk/health/article-8303305/Will-Covid-19-survivors-face-lifetime-illness-lik... |
Description | Interview with New York Times on my research on CFS/ME |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Journalist Moises Velasquez-Manoff interviewed me on my research on CFS/ME and its relevance to long-covid |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.nytimes.com/2021/01/21/magazine/covid-aftereffects.html |
Description | Interview with Vice.com on my research on CFS/ME |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Journalist Nichola Kelly interviewed me on my research on CFS/ME and its relevance to Long Covid |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.vice.com/en/article/z3evby/young-people-with-coronavirus-symptoms-relapse |
Description | Laboratory Facebook account |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | This is the Facebook page of the Stress, Psychiatry and Immunology Laboratory; The Stress, Psychiatry and Immunology Laboratory (SPI Lab) is an academic research laboratory within King's College London, led by Professor Carmine Pariante. Our team is made up of clinicians, research and postgraduate students who work across a range of clinical settings. Some of the disorders we investigate include depression, first-episode psychosis, women in the perinatal period (and their infants), individuals with history of trauma, and patients with inflammation-related medical disorders such as viral hepatitis and chronic fatigue. We place a strong emphasis on biological and molecular research relevant to mental health, using biological samples derived from patient populations, experimental cellular and animal models. |
Year(s) Of Engagement Activity | 2015,2016,2017,2018,2019,2020,2021 |
URL | https://www.facebook.com/SPILabKCL/ |
Description | Personal blog on the Huffington Post |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | regular entry blogs on topics related to mental health |
Year(s) Of Engagement Activity | 2015,2016 |
URL | http://www.huffingtonpost.co.uk/carmine-pariante/ |
Description | Personal twitter account |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | This is my personal twitter account: Carmine M. Pariante @ParianteSPILab - Psychiatrist and researcher @SPILabKCL. Writer & Editor @inspirethemind_ @BrainBehavImm @BBI_Health. President @ISPNE. Creativity. Social justice. And kung fu. |
Year(s) Of Engagement Activity | 2015,2016,2017,2018,2019,2020,2021 |
URL | https://twitter.com/ParianteSPILab |
Description | Plenary Lecture at the Conference of Forensic Psychiatry of the Royal College of Psychiatrists |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | A plenary lecture on my research on depression and inflammation |
Year(s) Of Engagement Activity | 2017 |
Description | Plenary Lecture at the Italian Society for Psychopathology |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | A plenary lecture on my research on depression and the immune system |
Year(s) Of Engagement Activity | 2017 |
Description | Press conference |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Press conference associated with a symposium on depression Private interviews with a radio, description on news websites |
Year(s) Of Engagement Activity | 2009 |
Description | Salon London public event on stress and mental health |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | More than 100 people attended this public event as part of Salon London, an established series of cultural events in London. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.salon-london.com/event/the-science-of-stress |
Description | Symposium at the Royal College of Psychiatrists |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | S33 Predicting response to antidepressants: Is it possible? Wednesday 1st of July 2015 Chair: Dr Hamish McAllister-Williams, Newcastle University HPA axis and inflammatory cytokines *Professor Carmine Pariante, Institute of Psychiatry, London Cognition and emotional processing Professor Catherine Harmer, University of Oxford EEG variables Dr Hamish McAllister-Williams, Newcastle University S54 Inflammation & Mental Health: An overview of perinatal and later life infection/inflammation on risk for common mental illnesses - - Thursday 2nd of July Chair: Prof Hugo Critchley, Brighton & Sussex Medical School Early-life infection alters glial function and increases susceptibility to cognitive and neuropsychiatric disorders including schizophrenia and autism Dr Staci Bilbo, Duke University Can blood and brain MRI biomarkers be used to identify patients most likely to benefit from 'anti-inflammatory' treatments? Dr Neil Harrison, University of Sussex Update on the current evidence supporting a role for 'anti-inflammatory' agents in the management of treatment resistant depression *Professor Carmine Pariante, Kings College London |
Year(s) Of Engagement Activity | 2015 |
Description | Visit of HRH The Duchess of Cambridge to Professor Pariante's laboratory |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | The Duchess of Cambridge visits King's College London's IoPPN and the Mother and Baby Unit at Bethlem Royal Hospital The Duchess of Cambridge visited Professor Pariante's laboratory at the Maurice Wohl Clinical Neuroscience Institute at King's College London to find out more about the Institute of Psychiatry, Psychology & Neuroscience's (IoPPN) pioneering 'bench to bedside' mental health research and to meet leading scientists in the area. The Duchess continued to the Mother and Baby Unit, Royal Bethlem Hospital, South London and Maudsley NHS Foundation Trust, to meet clinicians and patients. |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.kcl.ac.uk/ioppn/news/records/2018/january/duchess-of-cambridge-visits-kings-college-lond... |