Impact of sex steroids on immune and vascular cell function in the reproductive system
Lead Research Organisation:
University of Edinburgh
Department Name: School of Clinical Sciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Philippa Saunders (Principal Investigator) |
Publications
Gibson DA
(2012)
Estrogen dependent signaling in reproductive tissues - a role for estrogen receptors and estrogen related receptors.
in Molecular and cellular endocrinology
Fowler PA
(2011)
Development of steroid signaling pathways during primordial follicle formation in the human fetal ovary.
in The Journal of clinical endocrinology and metabolism
Smith LB
(2011)
The skeleton: the new controller of male fertility?
in Cell
Childs AJ
(2011)
Retinoic Acid signalling and the control of meiotic entry in the human fetal gonad.
in PloS one
Cervelló I
(2011)
Reconstruction of endometrium from human endometrial side population cell lines.
in PloS one
Welsh M
(2011)
Smooth muscle cell-specific knockout of androgen receptor: a new model for prostatic disease.
in Endocrinology
Saunders P
(2011)
Endo-immunology: interactions between the immune and endocrine systems. Introduction.
in Molecular and cellular endocrinology
Marshall E
(2011)
In silico analysis identifies a novel role for androgens in the regulation of human endometrial apoptosis.
in The Journal of clinical endocrinology and metabolism
| Description | Academy of Medical Sciences Careers Committee |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Endometriosis - James Lind PSP |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Impact | Management group of priority setting partnership in endometriosis run under the auspices of the James Lind Alliance. Financial support provided as part of public engagement commitment from grants. Surveys were conducted nationally and results led to publication of a top 10 priority for research - this is being considered by funders including NIHR (phone calls and discussions). High profile publication in the Lancet. Social media activity and engagement with clinical and research community. |
| Description | Asset Sharing Scheme |
| Amount | £302,097 (GBP) |
| Funding ID | MR/P00265X/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2017 |
| End | 12/2019 |
| Description | CRUK Edinburgh Centre Award |
| Amount | £170,000 (GBP) |
| Organisation | Cancer Research UK |
| Department | Edinburgh Cancer Research UK Centre |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2014 |
| End | 08/2017 |
| Description | Developmental Clinical Studies |
| Amount | £1,600,000 (GBP) |
| Funding ID | MR/J003611/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 12/2012 |
| End | 12/2016 |
| Description | MOMENDO |
| Amount | € 1,000,000 (EUR) |
| Funding ID | 691058 |
| Organisation | European Commission H2020 |
| Sector | Public |
| Country | Belgium |
| Start | 07/2016 |
| End | 07/2019 |
| Description | MRC Career Development Award (Erin Greaves) |
| Amount | £900,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2015 |
| End | 12/2020 |
| Description | MRC Development Clinical Studies |
| Amount | £1,423,676 (GBP) |
| Funding ID | MR/J003611/1 |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Clinical Sciences Centre (CSC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | Multiuser Equipment Grant |
| Amount | £793,450 (GBP) |
| Funding ID | 202794/Z/16/Z |
| Organisation | Wellcome Trust |
| Department | Wellcome Trust Bloomsbury Centre |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2016 |
| End | 09/2021 |
| Description | PhD studentship - Tissue Repair |
| Amount | £67,700 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 04/2015 |
| End | 09/2018 |
| Description | Programme Grant |
| Amount | £1,818,379 (GBP) |
| Funding ID | MR/N024524/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2016 |
| End | 03/2021 |
| Description | QMRI FACS facility core funding |
| Amount | £550,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | QMRI Mass Spectometry Facility |
| Amount | £739,245 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Research Project Grant |
| Amount | £125,788 (GBP) |
| Funding ID | MR/L002647/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2013 |
| End | 12/2015 |
| Description | Research Project Grant |
| Amount | £144,337 (GBP) |
| Funding ID | R42533 |
| Organisation | Wellbeing of Women |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2012 |
| End | 12/2014 |
| Title | Novel mouse model of endometriosis |
| Description | Model uses 'menstrual' uterine tissue injected into mouse peritoneum - lesions formed phenocopy those in patients. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | Inclusion of model in grant applications (Fellowship for Greaves, Grant for Australian collaborators); interest from Pharma with promise of funding |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/24910298 |
| Description | Studies on Endometriosis |
| Organisation | Catholic University of Louvain |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | Academic collaboration sharing ideas for publications and so-supervision of PhD student |
| Collaborator Contribution | Academic collaboration sharing ideas for publications and so-supervision of PhD student |
| Impact | Publications Grant for PhD student |
| Start Year | 2012 |
| Description | Studies on endometriosis associated pain |
| Organisation | Charité - University of Medicine Berlin |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Training of visiting PhD student; dissemination of animal model of endometriosis |
| Collaborator Contribution | Provision of human patient samples; PhD student time |
| Impact | Training of PhD student; invitation to give a talk in Berlin for postdoc; publication |
| Start Year | 2013 |
| Company Name | Ichtus |
| Description | Spin out from our work on Endometriosis - set up to conduct small clinical trials related to use of fish oils to control pain |
| Year Established | 2013 |
| Impact | None yet |
| Description | Androgens 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | Title of talk: 'Endometrial health and disease; impact of androgens' Opportunity to interact with peers. Raised profile internationally. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Departmental Seminar, Geissen Germany 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Title of Talk: Androgens: master regulators of male health Opportunity to network with peers. Increase profile. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Departmental Seminar, Geissen, Germany 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Kolloquium, Des Hessischen Zentrums fur Reproduktionsmedizin (HZRM), 12th February 2014. Title of Talk: 'Androgens - master regulators of male heath' Opportunity to network with peers. Raise profile. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.med.uni-giessen.de/hzrm |
| Description | Edinburgh Science Festival, April 2014 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Chaired Talks at Edinburgh Science Festival in April 2014. Edinburgh Science Festivals are held every year and are well attended by the public. Raises public awareness of reproductive health. Raised profile. Excellent feedback from public. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Endometriosis Patient Awareness Day 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Opportunity for members of the public to share and contribute to discussions. Good feedback from members of the public. |
| Year(s) Of Engagement Activity | 2014 |
| Description | International Competition for Sixth form students sponsored by MRC and Pfizer |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Interaction with school pupils - raised awareness of reproductive health. Raised profile. Media coverage and good feedback from schools, MRC and Pfizer. |
| Year(s) Of Engagement Activity | 2009,2010,2011,2012 |
| Description | Manchester University 2015 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | Invited to give talk entitled 'Human endometrium: mechanisms of steroid dependent receptivity, scarless repair and malignancy'. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Public Talk, Edinburgh Science Festival 2012 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Title of talk 'Sex,steroids: bodies, babies and brains'. Edinburgh Science Festival. 2011. Wide media coverage. Raised my profile and public awareness of reproductive science. Excellent feedback. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Research Methodology Course 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | The Research Methodology course took place at South Hall, Pollock Halls Campus, Edinburgh from 27-28 February 2014. The title of my talk was 'How to write the perfect grant proposal'. Allowed good networking/discussion with other colleagues in the field. The Research Methodology Course is held every year. The course is aimed at practitioners at all levels from all disciplines (including medical, allied health professionals, nursing and midwifery staff, and scientists) who have an interest in or are actively engaged in clinical research. The course allows for interactive lectures and opportunities for delegates to network with distinguished researchers, all of whom are recognised experts in their field. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.ecat.ed.ac.uk/research-methods/ |
| Description | San Diego USA Satelite Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Society for Gynecological Investigation Endometrial Satelite Meeting. Title of talk: 'Androgens and endometrial function - a role in regulation of endometrial bleeding?' 2012. Opportunity to interact with other researchers at international level. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Satellite Meeting World Congress of Endometriosis, San Paulo Brazil 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Satellite meeting, World Congress of Endometriosis, San Paulo Brazil - 30th April - 3rd May 2014. Opportunity to network on an international level with peers. Raise profile. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.allcongress.com/congress/12th-world-congress-on-endometriosis-wce-2014/ |
| Description | Satellite meeting World Congress Reproduction 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | Title of talk: Androgens and women's Health - new insights. Opportunity to network. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Science Competition |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | PhD Student (Gemma Sharp) won 'I'm a scientist get me out of here'. Widely publicised on line and in both MRC and University of Edinburgh publications/websites |
| Year(s) Of Engagement Activity | 2011 |
| Description | Uppsala University - Public Talk 2015 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | Invited to give public talk on 'Introduction to Viva'. Title of Talk 'Sex hormones, production, action and impact' |
| Year(s) Of Engagement Activity | 2015 |