PET Methodology

Lead Research Organisation: King's College London
Department Name: Neuroimaging

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

In the next five years we want to progress the set of technologies that PET Methodology has built at Hammersmith for the field in the past 20 years with the aim of increasing PET accuracy and expand its applications to provide ever more useful end-points for diagnostic use, clinical research and drug development. We will support the introduction of new tracers in the Unit (e.g. 11C-Ro-154513, 11CCUMI, 11C-CNS-5161, 11C-MePPEP) developing tailored quantitative methodologies. We will employ novel modeling approaches (e.g. generalized reference region models) to simplify,without loss of precision, the use of PET in research and drug development. To support the imaging work in Neurodegeneration, we will expand our methodological toolbox on imaging inflammation developing quantification methods for the new generation of high affinity TSPO radiotracers such as 11C-PBR28 and 18F-FEPPA. We will be also looking at translational models of senescence to identify aging microglia phenotypes and their markers.
To support the work in Psychiatric disorders, we will develop methodologies able to quantify the dynamics of large neuronal ensembles from fMRI time-courses looking both at local and regional determinants using concepts from network analysis and statistical physics. We will then use these endpoints in combined fMRI/PET study designs to measure the relationship between receptor densities/endogenous neurotransmitters levels (e.g. using dopaminergic tracers such as 18F-FDOPA, 11C-Raclopride, 11C-FLB457 or cannabinoid tracers such as 11C-CB1) and neuronal dynamics.
In Cancer, we will work on two paths. On one side we will research novel quantification methodologies for radiotracers used in clinical studies at the Unit (18FFluorothymidine, 18F- AH111585 e 18CCholine) to model their complex and heterogeneous kinetic behavior in tumor cells. In parallel, we will be developing computer aided strategies able to use features of functional (PET) and structural (CT) images to automatically detect tumors in functional or multimodal studies. Our work on Genomics will continue with focus on the epigenetics of brain disorders (Huntington‘s and Parkinson‘s disease, Schizophrenia and bipolar disorders) using computational models applied to microarray data for exploration and guide for further genomic (ChIP-Seq) studies.

Publications

10 25 50

publication icon
Albrecht DS (2018) Pseudoreference Regions for Glial Imaging with C-PBR28: Investigation in 2 Clinical Cohorts. in Journal of nuclear medicine : official publication, Society of Nuclear Medicine

publication icon
Angelis GI (2011) Convergence optimization of parametric MLEM reconstruction for estimation of Patlak plot parameters. in Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society

publication icon
Ball G (2011) Executive functions and prefrontal cortex: a matter of persistence? in Frontiers in systems neuroscience

publication icon
Bertoldo A (2014) Deriving physiological information from PET images: from SUV to compartmental modelling in Clinical and Translational Imaging

publication icon
Bloomfield MA (2014) Dopamine function in cigarette smokers: an [¹8F]-DOPA PET study. in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

 
Title Neuroscience and Graphic Design 
Description This is a digital image library to improve peer-to-peer scientific graphical communication 
Type Of Art Artefact (including digital) 
Year Produced 2017 
Impact Linked to this initiative we organised a set of workshop to improve the creation of scientific and conceptual figures. A description of the event is reported here: https://neuroscience-graphicdesign.com/workshops/ 
URL https://neuroscience-graphicdesign.com
 
Title Prudent to Prune? 
Description Neuroinflammation in schizoprenia 
Type Of Art Image 
Year Produced 2015 
Impact Scientific dissemination and public engagement 
URL http://bpod.mrc.ac.uk/archive/2015/10/17
 
Description Book: Statistics without equations
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact New book published on Amazon devoted to the explanation of the basics tenets of statistics to the wider public (e.g. secondary school to postgraduate students, the general public).
URL https://www.amazon.co.uk/Statistics-without-equations-Federico-Turkheimer/dp/1530908213
 
Description Experimental Design and Practical Data Analysis in PET - The Book
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact The book contains all the basic notions of Positron Emission Tomography that span from physiology to radiochemistry, physics, math and statistics. All material was carefully crafted and is presented in graphical manner to ease reading, studying and browsing. It suits equally undergraduate and graduate academic students but it has been of interest to clinical fellows or professionals in the biomedical sector that use PET in their activity or develop technologies in the area. The book has been a top 10 best seller in Amazon and is used as standard textbook in a number of medical imaging courses around the globe
 
Description The PET Experimental Design and Data Analysis Course
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description ARSEP - Travel Grant Bursary
Amount € 5,000 (EUR)
Organisation ARSEP Foundation 
Start 03/2014 
End 03/2015
 
Description BBSRC-LiDO
Amount £100,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2017 
End 09/2020
 
Description Centre for doctoral training in medical imaging
Amount £5,000,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 10/2014 
End 09/2019
 
Description Dopamine release and blood flow changes during induced epileptic seizures assessed with simultaneous PET-MR-EEG
Amount £659,974 (GBP)
Funding ID MR/N013042/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2016 
End 12/2017
 
Description EC-FP7 InMIND
Amount £725,000 (GBP)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 04/2011 
End 03/2016
 
Description ECTRIMS Fellowship
Amount € 100,000 (EUR)
Organisation European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) 
Sector Charity/Non Profit
Country European Union (EU)
Start 01/2014 
End 12/2015
 
Description GENESIS: Molecular and Imaging Markers of Drug induced cerebral plasticity
Amount £90,000 (GBP)
Funding ID R140805 
Organisation King’s Health Partners 
Department King's Health Partners Research and Development Challenge Fund
Sector Charity/Non Profit
Country United Kingdom
Start 01/2015 
End 12/2015
 
Description Glaxo Smithkline - Excellence in Imaging Centre
Amount £400,000 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 07/2017 
End 08/2019
 
Description IMéRA team residency
Amount € 1,000 (EUR)
Organisation IMéRA 
Sector Academic/University
Country France
Start 03/2017 
End 04/2017
 
Description Innovative Medicine Initiative (IMI)
Amount € 8,838,000 (EUR)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 11/2016 
End 10/2021
 
Description Janssen Pharmaceuticals
Amount £80,000 (GBP)
Organisation Johnson & Johnson 
Department Janssen Pharmaceuticals
Sector Private
Country United States
Start 01/2013 
End 12/2017
 
Description Myelin imaging in MS
Amount € 35,000 (EUR)
Organisation ARSEP Foundation 
Start 01/2017 
End 12/2018
 
Description Simultaneous PET-MR Modelling and Reconstruction for Imaging Brain Disorders
Amount £606,702 (GBP)
Funding ID EP/M020142/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 08/2015 
End 07/2018
 
Description Targeting neuroinflammation in schizophrenia
Amount £841,703 (GBP)
Funding ID MR/N027078/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2016 
End 09/2019
 
Description The Resilient Brain. Imaging Biomarkers of Brain Metabolic Reserve
Amount £900,000 (GBP)
Funding ID BB/N009088/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 06/2016 
End 05/2019
 
Description Wellcome Trust Consortium for Neuroimmunology of Mood Disorders and Dementia (NIMA).
Amount £5,000,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2017 
End 12/2018
 
Description Aarhus Hospital 
Organisation Aarhus University Hospital
Country Denmark 
Sector Academic/University 
PI Contribution We analysed the PET data using the SUPERPK approach developed by our team.
Collaborator Contribution Aarhus Hospital provided us clinical PET data of patients who has spinal cord injury;
Impact In vivo PET data has been analysed to investigate the inflammation associated with spinal cord injury. This is a multi-disciplinary collaboration as it covers area of medicine, neurology, imaging and quanfication.
Start Year 2010
 
Description CNR 
Organisation San Raffaele Hospital
Department Department of Biological and Technological Research (DIBIT)
Country Italy 
Sector Academic/University 
PI Contribution Contributed neural-net technology for the extraction of PET imaging biomarkers in schizophrenia
Collaborator Contribution Collaborative work on grid-based computational diagnostic
Impact EU-FP7 Grant, DECIDE
Start Year 2009
 
Description Center for Integrated Molecular Brain Imaging 
Organisation Lundbeck Foundation
Country Denmark 
Sector Charity/Non Profit 
PI Contribution Development of network-based approaches for brain PET data analysis
Collaborator Contribution Access to PET database and scientific advisory
Impact BrainPET 2017 conference proceeding
Start Year 2016
 
Description Computational simulation of ligands able to bind Metabotropic glutamate receptor 1. 
Organisation University of Bologna
Department Department of Pharmacy and Biotechnology (FaBiT)
Country Italy 
Sector Academic/University 
PI Contribution Design of a virtual library of small compounds (100 molecules) able to bind the mGluR1.
Collaborator Contribution Computational docking simulation of a virtual library of small compounds able to bind the mGluR1. Analysis and scoring of the molecules.
Impact Selection of three molecules that will be synthesized and tested in vitro.
Start Year 2015
 
Description Dr. Paolo Zanotti-Fregonara (University of Bordeaux, Fr) 
Organisation Houston Methodist Research Institute
Country United States 
Sector Charity/Non Profit 
PI Contribution Dr. Zanotti-Fregonara shared with us his PET datasets (acquired in collaboration with National Institutel of Mental Health). With this data we had the opportunity to test and validate some of the new modelling approaches for quantification of neuroinflammation PET tracers that are currently in use for tracers like 11C-PBR28.
Collaborator Contribution The role of Dr. Zanotti-Fregonara in this collaboration has not been limited to sharing the data. He actively interacts with us to elaborate new theories about the role of neuroinflammation in many diseases and disorders of the central nervous system. These reasearches are still ongoing
Impact Peer reviewed publications and conference proceedings
Start Year 2013
 
Description Dr. Sudhakar Selvaraj (UTHealth - The University of Texas) 
Organisation University of Texas
Department Health Science Center at Houston
Country United States 
Sector Academic/University 
PI Contribution We are assisting Dr. Sudhakar Selvaraj to set up a PET platform to image neuroinflammation in several conditions.
Collaborator Contribution Dr. Sudhakar Selvaraj is an Assistant Professor at the department of Psychiatry and Behavioral Sciences at UT health science center Houston. His research has primarily focused on understanding the neurobiological mechanisms underlying the mood and psychotic disorders. He has specific training and expertise in brain imaging techniques, both structural and functional Magnetic Resonance Imaging/Spectroscopy and Positron Emission Tomography (PET) imaging and its applications in neuropsychiatric disorders.
Impact Current research is investigating the link between neuroinflammation and cortical volume reduction in schizophrenia.
Start Year 2015
 
Description Graph Signal Analysis 
Organisation National Institute of Informatics (NII)
Country Japan 
Sector Public 
PI Contribution Theoretical development of GSA
Collaborator Contribution Theoretical development of GSA
Impact Multidisciplinary: applied-mathematics and neurosciences
Start Year 2015
 
Description IMANOVA 
Organisation Imanova
Country United Kingdom 
Sector Private 
PI Contribution Jointly set-up computational platform for PET data-analysis.
Collaborator Contribution Joint methodological work on clinical studies on Positron Emission Tomography
Impact Collaboration just started. A series of grant applications are expected
Start Year 2011
 
Description ISI Foundation 
Organisation ISI Foundation - Institute for Scientific Interchange
Country Italy 
Sector Charity/Non Profit 
PI Contribution Data pipeline, ideas to apply their methodology
Collaborator Contribution Application of persistent homology to the study of complex networks structure.
Impact The collaboration just started, no quantifiable output yet. Multidisciplinary: mathematics, complex system, neuroimaging
Start Year 2012
 
Description Imperial College London 
Organisation Imanova
Country United Kingdom 
Sector Private 
PI Contribution Methodology development and quantification for imaging neuroinflammation in HTLV-1 patients Quantification of the specific binding of the second generation TSPO tracers using blocking agents
Collaborator Contribution Imperial college initialised the study initialisation. Study was operated by Imanova
Impact This work has been presented in SNMMI annual meeting 2013
Start Year 2013
 
Description NIRS Chiba - Japan 
Organisation National Institute of Radiological Science (NIRS)
Department Molecular Imaging Centre (NIRS)
Country Japan 
Sector Public 
PI Contribution Collaborative Research PET Methodology
Collaborator Contribution Collaborative Research Papers
Impact Royal Society Travel Grant 2 collaborative publications
Start Year 2009
 
Description Prof. Bruno Stankoff (Paris, FRA) 
Organisation National Institute of Health and Medical Research (INSERM)
Department INSERM U952 (Pathophysiology of central nervous system diseases)
Country France 
Sector Public 
PI Contribution Quantitative PET methodology for [11C]PIB in the quantification of myelin in Multiple Sclerosis
Collaborator Contribution Clinical MS [11C]PIB scans, recruitment of MS patients, neurological assessment on patients
Impact SuperPIB - Quantification software, optimisation of quantification and post-processing of [11C]PIB PET data acquired on a high-resolution research homograph, Multimodal Partial Volume Correction of [11C]PIB PET scans in MS
Start Year 2012
 
Description Section on Neuroadaptation and Protein Metabolism 
Organisation National Institutes of Health (NIH)
Department Section on Neuroadaptation and Protein Metabolism
Country United States 
Sector Public 
PI Contribution Development of quantification methods for nalysis of L[1-11C]Leucine PET studies
Collaborator Contribution PI of the project. Provide data and expertise
Impact Optimization of an analysis method usable potentially useful for all the irreversible PET tracer.
Start Year 2008
 
Description University of Padova 
Organisation University of Padova
Department Department of Information Engineering
Country Italy 
Sector Academic/University 
PI Contribution PhD student supervision
Collaborator Contribution Time for staff and students to projects
Impact Joint papers, software packages
Start Year 2006
 
Title Brain Chopper 
Description Matlab based software to aid stereology analysis of digital histology slides 
Type Of Technology Software 
Year Produced 2016 
Open Source License? Yes  
Impact Enable stereology-based cell counting method for digital slides 
 
Title MENGA 
Description MENGA is a platform for the integration of imaging data and Allen Human Brain Atlas mRNA data. MENGA aims to provide a comprehensive environment to investigate correlation patterns between various imaging modalities and gene expression profiles based on the Allen Brain Atlas. The project comes from a collaboration between the Department of Information Engineering (DEI), University of Padova with the Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College, London (UK). 
Type Of Technology Software 
Year Produced 2016 
Open Source License? Yes  
Impact The tool offers the possibility to integrate neuroimaging and genomic data 
URL http://fair.dei.unipd.it/software/
 
Title Q-BOX 
Description A software toolbox for the quantification of PET studies using region-of-interest data. It is a comprehensive collection of linear, compartmental and spectral analytical approaches for the processing of both tissue and blood data 
Type Of Technology Software 
Year Produced 2012 
Impact Popular software for PET analysis 
 
Title SAKE 
Description Novel Spectral Analysis Software package for the quantification of PET data 
Type Of Technology Software 
Year Produced 2012 
Open Source License? Yes  
Impact Downloaded from several (>30) research centres worldwide 
URL http://bio.dei.unipd.it/sake/cgi-bin/index.cgi
 
Title SFS-RR 
Description Matlab Toolbox for Partial Volume Correction of PET images using MRI structural information and wavelet technology. This software was developed in collaboration with the University of Tohoku, Japan 
Type Of Technology Software 
Year Produced 2013 
Open Source License? Yes  
Impact Unique in his kind, it is the only available technology to correct partial volume effects directly onimages. 
URL http://www.noninvasive.med.tohoku.ac.jp/ShidaharaLab/SFSRR.html
 
Description 1st International Training School on PET-MRI Engineering 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact PhD students across entire Europe working in Neuroimaging field

New acquisition modalities and image analysis approaches are now tested in multiple research centers
New collaborations across institutes
Year(s) Of Engagement Activity 2014
URL http://www.pet-mri.eu/PETMR_School_14.html
 
Description BBSRC & Biochemical Society "Sparking Impact" meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact This focused meeting aims to summarize the state of the art knowledge on TSPO science and create the nexus of the discipline-based segregated concepts by summoning the leading scientists, from academia and industry, and clinicians in the field.
Year(s) Of Engagement Activity 2015
 
Description KCL Molecular Neuroimaging YouTube Channel 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact We have created a YouTube channel where we have installed a series of introductory lectures as well as short pieces presenting to the interested public our research work
Year(s) Of Engagement Activity 2017,2018
URL https://www.youtube.com/channel/UCCu_TK13NmIU8LXIFj_XU7A
 
Description PET Methodology Course 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The PET MEthodology course is a 3 days course attended by academics, NHS staff and professionals from Industry (GE, Phillips) and Pharma (GSK, Novartis, Roche) from the whole of the UK and from abroad.

The course has been running since 2008 with more than 500 participants and is regularly overbooked
Year(s) Of Engagement Activity 2008,2009,2010,2011,2012
URL https://www.kcl.ac.uk/prospectus/images/uploads/accreditions/PET_course_PROGRAM_March2014.pdf
 
Description Pint of Science 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The Pint of Science festival aims to deliver interesting, fun, relevant talks on the latest science research in an accessible format to the public - all in the pub! We want to provide a platform which allows people to discuss research with the people who carry it out. It is run by volunteers and was established by a community of postgraduate and postdoctoral researchers in 2012. The main festival takes place annually over three days in the month of May simultaneously in pubs across the world. Pint of Science is a non-profit organisation.
Year(s) Of Engagement Activity 2015
URL https://pintofscience.co.uk/
 
Description TSPO Workshop Manchester 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Consensus meeting on imaging neuro-inflammation with PET

The meeting lead to the successful strategic grant application to the Wellcome
Year(s) Of Engagement Activity 2014