Gene targeting in human embryonic stem cells: A novel in vitro approach to modelling Duchenne Muscular Dystrophy (DMD)
Lead Research Organisation:
Nottingham Uni Hospitals NHS Trust
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
- Nottingham Uni Hospitals NHS Trust, United Kingdom (Lead Research Organisation)
- Loughborough University, United Kingdom (Collaboration)
- National Institute for Biological Standards and Control (NIBSC) (Collaboration)
- Tecan UK Ltd (Collaboration)
- Newcastle University, United Kingdom (Collaboration)
- University of Hamburg, Germany (Collaboration)
- Queen Mary, University of London, United Kingdom (Collaboration)
- Cardiff University, United Kingdom (Collaboration)
- Massachusetts Institute of Technology (Collaboration)
- University of A Coruna (Collaboration)
- University of Nottingham (Collaboration)
- Medicines Discovery Catapult (Collaboration)
- Imperial College London, United Kingdom (Collaboration)
- Pluriomics BV (Collaboration)
- GlaxoSmithKline (GSK) (Collaboration)
- Centre for Life (Collaboration)
- The Wellcome Trust Sanger Institute (Collaboration)
- University of Glasgow, United Kingdom (Collaboration)
- Technion Israel Institue of Technology, Israel (Collaboration)
- University of Leiden, Netherlands (Collaboration)
- Syngenta International AG (Collaboration)
- University of Manchester, Manchester, United Kingdom (Collaboration)
- Tokyo Electron (Collaboration)
- King's College London, United Kingdom (Collaboration)
- University of Nottingham, United Kingdom (Fellow)
People |
ORCID iD |
| Chris Denning (Principal Investigator / Fellow) |
Publications
Matsa E
(2012)
In vitro uses of human pluripotent stem cell-derived cardiomyocytes.
in Journal of cardiovascular translational research
Paik I
(2012)
Rapid micropatterning of cell lines and human pluripotent stem cells on elastomeric membranes.
in Biotechnology and bioengineering
Pascut FC
(2011)
Noninvasive detection and imaging of molecular markers in live cardiomyocytes derived from human embryonic stem cells.
in Biophysical journal
Pascut FC
(2011)
Toward label-free Raman-activated cell sorting of cardiomyocytes derived from human embryonic stem cells.
in Journal of biomedical optics
Pascut FC
(2013)
Non-invasive label-free monitoring the cardiac differentiation of human embryonic stem cells in-vitro by Raman spectroscopy.
in Biochimica et biophysica acta
Passier R
(2006)
Cardiomyocytes from human embryonic stem cells.
in Handbook of experimental pharmacology
Patel A
(2016)
High throughput screening for discovery of materials that control stem cell fate
in Current Opinion in Solid State and Materials Science
Porter G
(2006)
The patentability of human embryonic stem cells in Europe.
in Nature biotechnology
| Description | EU Stem Cell Patents |
| Geographic Reach | National |
| Policy Influence Type | Participation in advisory committee |
| Description | GTAC |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guidance committee |
| Description | Masters course |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | masters levels training in stem cell technologies |
| Description | NC3Rs policy document on regenerative medicine (Kevin Shakesheff 2015) |
| Geographic Reach | National |
| Policy Influence Type | Participation in a national consultation |
| Description | Animal Free Research UK "Villains and victims - Deciphering the impact of cell- and mutation-type on cardiac fibrosis". |
| Amount | £146,740 (GBP) |
| Funding ID | AFR19-20293 |
| Organisation | Animal Free Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2020 |
| End | 05/2023 |
| Description | Asha E-term fellowship |
| Amount | £250,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2013 |
| End | 11/2015 |
| Description | BBSRC IPA |
| Amount | £1,300,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2009 |
| End | 03/2013 |
| Description | BHF Centre for Regen Med |
| Amount | £2,500,000 (GBP) |
| Funding ID | P47352/ |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2013 |
| End | 09/2017 |
| Description | BHF LQTS grant (Elena) |
| Amount | £189,000 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2010 |
| End | 02/2013 |
| Description | BHF MyoD grant |
| Amount | £300,000 (GBP) |
| Funding ID | PG/14/59/31000 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2015 |
| End | 05/2018 |
| Description | BHF Programme Grant (2 pilot with Sian Harding) |
| Amount | £475,000 (GBP) |
| Funding ID | RG/11/19/29264 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2012 |
| End | 04/2014 |
| Description | BHF programme 2014-17 |
| Amount | £1,125,000 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2014 |
| End | 04/2017 |
| Description | EMDA |
| Amount | £36,000 (GBP) |
| Organisation | East Midlands Development Agency |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2011 |
| End | 09/2011 |
| Description | EP/H028277/1 EPSRC Centre for Innovative Manufacturing in Regenerative Medicine |
| Amount | £5,259,190 (GBP) |
| Funding ID | EP/H028277/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2010 |
| End | 09/2015 |
| Description | EPSRC 'Future-Proof' Synthetic Surfaces |
| Amount | £2,300,000 (GBP) |
| Funding ID | EP/H045384/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2010 |
| End | 04/2014 |
| Description | EPSRC equip - seahorse |
| Amount | £115,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2014 |
| End | 03/2015 |
| Description | EU - dave |
| Amount | £300,000 (GBP) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 09/2012 |
| End | 08/2015 |
| Description | Heart Res UK (Divya) |
| Amount | £147,000 (GBP) |
| Funding ID | TRP01/12 |
| Organisation | Heart Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2013 |
| End | 01/2015 |
| Description | Int studentship - spandan |
| Amount | £90,000 (GBP) |
| Organisation | University of Nottingham |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2011 |
| End | 12/2014 |
| Description | MRC DMD grant 2009 |
| Amount | £550,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2009 |
| End | 10/2012 |
| Description | MRC capital equipment |
| Amount | £714,000 (GBP) |
| Funding ID | MR/L012618/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2013 |
| End | 03/2014 |
| Description | NC3Rs main panel (Viola) |
| Amount | £515,000 (GBP) |
| Funding ID | NC/K000225/1 |
| Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2013 |
| End | 02/2016 |
| Description | NC3Rs-CRACK-IT phase 1 |
| Amount | £100,000 (GBP) |
| Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2013 |
| End | 06/2014 |
| Description | NC3Rs-CRACK-IT phase 2 |
| Amount | £1,000,000 (GBP) |
| Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2015 |
| End | 01/2018 |
| Description | SC4SM cardiomyocyte call |
| Amount | £80,000 (GBP) |
| Organisation | Stem Cells for Safer Medicines (SC4SM) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2009 |
| End | 09/2010 |
| Description | University of Nottingham Strategic Development Fund "Nottingham Regenerative Medicine Centre" 1.1.15-31.12.18. £602,140 (PI) |
| Amount | £602,000 (GBP) |
| Funding ID | n/a |
| Organisation | University of Nottingham |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 11/2014 |
| End | 10/2020 |
| Description | Validating CRISPR-engineered human pluripotent stem cell-derived cardiomyocytes as tools to assist with toxicity profiling, adverse drug reaction notices and black box warnings |
| Amount | £49,996 (GBP) |
| Funding ID | NC/T2T0119 |
| Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2019 |
| End | 07/2020 |
| Description | epsrc DTG (Asha) |
| Amount | £150,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2011 |
| End | 09/2014 |
| Description | • BHF Programme Grant RG/15/6/31436: Predicting anti-arrhythmic drug efficacy from the divergent molecular basis of RyR2 dysfunction in genetic arrhythmia syndromes |
| Amount | £1,100,000 (GBP) |
| Funding ID | RG/15/6/31436 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2015 |
| End | 09/2020 |
| Description | • BHF Special Project no. SP/15/9/31605. "Coupling gene targeted reporters with fully automated compound library screening to mature hPSC-cardiomyocytes". |
| Amount | £1,100,000 (GBP) |
| Funding ID | SP/15/9/31605 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 12/2019 |
| Description | • BIRAX grant 04BX14CDLG. Gene targeted optogenetics in hPSC-cardiovascular cells for transplantation into animal models of heart dysfunction. 1.9.15-31.8.18. £400K |
| Amount | £400,000 (GBP) |
| Funding ID | 04BX14CDLG |
| Organisation | British Council |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2015 |
| End | 10/2018 |
| Description | • EPSRC Impact Accelerator Award. A Strategic Partnership with the Australian Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM) to Commercialise Stem Cell Culture Polymers |
| Amount | £67,000 (GBP) |
| Funding ID | n/a |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2015 |
| End | 02/2017 |
| Description | • EPSRC Programme Grant EP/N006615/1: 'Next Generation Biomaterials Discovery'. PI: Morgan Alexander. Multiple Co-Is. 1.10.15-30.9.20. £6.6m |
| Amount | £6,600,000 (GBP) |
| Funding ID | EP/N006615/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2015 |
| End | 09/2020 |
| Description | • MRC grant MR/M017354/1: MICA: Development of Metrics and Quality Standards for Scale up of Human Pluripotent Stem Cells. 1.5.15-30.4.17 £1. |
| Amount | £1,200,000 (GBP) |
| Funding ID | MR/M017354/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2015 |
| End | 04/2017 |
| Title | F1000Research article (Bhagwan) |
| Description | Published methods or targeting to safe harbour locus in human pluripotent stem cells |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | Interest, views and uptake by other researchers |
| URL | https://doi.org/10.6084/m9.figshare.c.4573316.v1 |
| Title | Human ES cell lines |
| Description | We derived 2 new human ES cell lines (NOTT1 and NOTT2) that were deposited to the UK Stem Cell Bank and are available for distribution |
| Type Of Material | Cell line |
| Year Produced | 2006 |
| Provided To Others? | Yes |
| Impact | Availability of new human ES cell lines for academic use |
| Title | Methods & Protocols article (Mosqeira) |
| Description | High throughput approaches for non-subjective quantification of cardiomyocyte function in vitro |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | Uptake, interest and use by others - one published article followed pretty much exactly the criteria we set out word for word, which gave us extra confidence and validation..! Link to PMID: 31717790 for our article |
| Title | genome editing |
| Description | genome editing techniques and cell lines |
| Type Of Material | Cell line |
| Year Produced | 2013 |
| Provided To Others? | Yes |
| Impact | developing UK and EU portfolio of research tools and assisting collaborations / grants |
| Title | hiPSC lines |
| Description | hiPSC lines carrying mutations in long QT syndrome genes |
| Type Of Material | Cell line |
| Year Produced | 2011 |
| Provided To Others? | Yes |
| Impact | 1. Braam SR, Tertoolen L, Casini S, Matsa E, Lu HR, Teisman A, Passier R, Denning C, Gallacher DJ, Towart R, Mummery CL. (2012) Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes. Stem Cell Research. 10(1):48-56. PMID: 23089628 |
| URL | http://europepmc.org/abstract/MED/23089628 |
| Description | Automation (Development of robot) |
| Organisation | Tecan UK Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Bespoke robotic platform for automated culture and differentiation of human stem cells |
| Collaborator Contribution | Role in automation |
| Impact | Publications, grants |
| Start Year | 2010 |
| Description | BIRAX interactions (Mummery, Gepstein) |
| Organisation | Technion - Israel Institute of Technology |
| Country | Israel |
| Sector | Academic/University |
| PI Contribution | New partnership between three labs |
| Collaborator Contribution | Skills in progenitor cell biology and cell transplantation in vivo |
| Impact | Early stage at present |
| Start Year | 2015 |
| Description | BRIC - Loughborough |
| Organisation | Loughborough University |
| Department | Department of Engineering |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research collaboration to secure funds |
| Impact | publications |
| Start Year | 2009 |
| Description | CRACK-IT consortium |
| Organisation | GlaxoSmithKline (GSK) |
| Department | Safety Assessment GSK |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | consortium working on safety assessment |
| Collaborator Contribution | all active contributors to researcher and academic input |
| Impact | publications and grants |
| Start Year | 2014 |
| Description | CRACK-IT consortium |
| Organisation | Leiden University |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | consortium working on safety assessment |
| Collaborator Contribution | all active contributors to researcher and academic input |
| Impact | publications and grants |
| Start Year | 2014 |
| Description | CRACK-IT consortium |
| Organisation | Pluriomics BV |
| Country | Netherlands |
| Sector | Private |
| PI Contribution | consortium working on safety assessment |
| Collaborator Contribution | all active contributors to researcher and academic input |
| Impact | publications and grants |
| Start Year | 2014 |
| Description | CRACK-IT consortium |
| Organisation | University of Glasgow |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | consortium working on safety assessment |
| Collaborator Contribution | all active contributors to researcher and academic input |
| Impact | publications and grants |
| Start Year | 2014 |
| Description | CRACK-IT consortium |
| Organisation | University of Hamburg |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | consortium working on safety assessment |
| Collaborator Contribution | all active contributors to researcher and academic input |
| Impact | publications and grants |
| Start Year | 2014 |
| Description | DM1 grant & activity (Lochmuller) |
| Organisation | Newcastle University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Joint BHF grant |
| Collaborator Contribution | Academic collaboration; joint posts; sharing of reagents and data |
| Impact | Joint grant, hence economic |
| Start Year | 2015 |
| Description | DMD (Lochmuller) |
| Organisation | Centre for Life |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | led research |
| Collaborator Contribution | publications & grant |
| Impact | grants & publications |
| Start Year | 2009 |
| Description | Drug Discovery Catapult |
| Organisation | Medicines Discovery Catapult |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Contribution of human pluripotent stem cell and cardiomyocyte disease modelling and drug screening |
| Collaborator Contribution | Knowledge of drug development, complex models and technology platforms |
| Impact | Project started March 2020 |
| Start Year | 2019 |
| Description | Electrophysiology mechanisms (Harmer / Tinker) |
| Organisation | Queen Mary University of London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | mechanism of electrophysiology in hPSC-cardiomyocytes |
| Collaborator Contribution | Skills in detailed electrophyioslogy |
| Impact | grants awarded. Papers in progress |
| Start Year | 2014 |
| Description | Genome editing (Skarnes) |
| Organisation | The Wellcome Trust Sanger Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Skills exchange and training for staff in Nottingham |
| Collaborator Contribution | Carrying out the research and intellectual input |
| Impact | Attracted several new grants of value £2m, introduced new skills to the team, leading to new national / international collaborations |
| Start Year | 2012 |
| Description | Imperial (Sian Harding) |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | multiple activities on grants, papers, sharing skills, reagents etc |
| Collaborator Contribution | multiple activities on grants, papers, sharing skills, reagents etc |
| Impact | multiple activities on grants, papers, sharing skills, reagents etc |
| Start Year | 2010 |
| Description | Industrial collaboration (GSK via CRACK-IT) |
| Organisation | GlaxoSmithKline (GSK) |
| Department | Safety Assessment GSK |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Facilitated award of NC3Rs CRACK-IT grant |
| Collaborator Contribution | Implicit in the sponsorship and construction of the challenge |
| Impact | Financial, international collaboration, skills sharing, joint PhD students, researcher exchange |
| Start Year | 2013 |
| Description | LQT (Staniforth) |
| Organisation | University of Nottingham |
| Department | School of Clinical Sciences Nottingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | led collab |
| Collaborator Contribution | publications |
| Impact | publications and grants |
| Start Year | 2010 |
| Description | MIT (Asha Patel, E-term) |
| Organisation | Massachusetts Institute of Technology |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | E-Term Fellowship and sabbatical |
| Collaborator Contribution | E-Term Fellowship and sabbatical |
| Impact | E-Term Fellowship and sabbatical |
| Start Year | 2013 |
| Description | MRC-TEL consortium (Manchester, UKSCB, Sanger, TEL) |
| Organisation | National Institute for Biological Standards and Control (NIBSC) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | joint grant with industrial partner |
| Collaborator Contribution | joint grant with industrial partner |
| Impact | joint grant with industrial partner |
| Start Year | 2015 |
| Description | MRC-TEL consortium (Manchester, UKSCB, Sanger, TEL) |
| Organisation | The Wellcome Trust Sanger Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | joint grant with industrial partner |
| Collaborator Contribution | joint grant with industrial partner |
| Impact | joint grant with industrial partner |
| Start Year | 2015 |
| Description | MRC-TEL consortium (Manchester, UKSCB, Sanger, TEL) |
| Organisation | Tokyo Electron |
| Country | Japan |
| Sector | Private |
| PI Contribution | joint grant with industrial partner |
| Collaborator Contribution | joint grant with industrial partner |
| Impact | joint grant with industrial partner |
| Start Year | 2015 |
| Description | MRC-TEL consortium (Manchester, UKSCB, Sanger, TEL) |
| Organisation | University of Manchester |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | joint grant with industrial partner |
| Collaborator Contribution | joint grant with industrial partner |
| Impact | joint grant with industrial partner |
| Start Year | 2015 |
| Description | Maturation grant (Tinker, Smith, Fischer) |
| Organisation | Queen Mary University of London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | joint grant and development of equipment, new molecules, cell resources |
| Collaborator Contribution | joint grant and development of equipment, new molecules, cell resources |
| Impact | joint grant and development of equipment, new molecules, cell resources |
| Start Year | 2015 |
| Description | Maturation grant (Tinker, Smith, Fischer) |
| Organisation | University of Glasgow |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | joint grant and development of equipment, new molecules, cell resources |
| Collaborator Contribution | joint grant and development of equipment, new molecules, cell resources |
| Impact | joint grant and development of equipment, new molecules, cell resources |
| Start Year | 2015 |
| Description | Sharing hiPSC lines (Pluriomics) |
| Organisation | Pluriomics BV |
| Country | Netherlands |
| Sector | Private |
| PI Contribution | Provision of hiPSC lines, intellectual input to project |
| Collaborator Contribution | Used our resources and input to carry out project |
| Impact | Braam SR, Tertoolen L, Casini S, Matsa E, Lu HR, Teisman A, Passier R, Denning C, Gallacher DJ, Towart R, Mummery CL. (2012) Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes. Stem Cell Research. 10(1):48-56. PMID: 23089628 |
| Start Year | 2011 |
| Description | Spannish patients (Roberto Barriales-Villa) |
| Organisation | University of A Coruña |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | provision of patient samples to underpin research |
| Collaborator Contribution | provision of patient samples to underpin research |
| Impact | provision of patient samples to underpin research |
| Start Year | 2015 |
| Description | electrophysiology (CPVT, George / Williams) |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | electrophysiology of cardiomyocytes |
| Collaborator Contribution | Developed to £1.1m BHF grant |
| Impact | Grant secured. Working towards papers |
| Start Year | 2010 |
| Description | exon skipping (Leiden, Aartsma-Rus) |
| Organisation | Leiden University |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | brought skills to the team not available in Nottingham |
| Collaborator Contribution | reagents and expertise in exon skipping |
| Impact | Publication of paper |
| Start Year | 2011 |
| Description | surface work (Morgan Alexander, Nottingham) |
| Organisation | University of Nottingham |
| Department | School of Pharmacy |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | lead the stem cell work of this collaboration |
| Collaborator Contribution | Multiple grant awards and papers |
| Impact | grants and papers |
| Start Year | 2010 |
| Description | syngenta |
| Organisation | Syngenta International AG |
| Country | Switzerland |
| Sector | Private |
| PI Contribution | stem cell automation |
| Collaborator Contribution | intellectual and financial input |
| Impact | advances in stem cell automation |
| Start Year | 2009 |
| Description | virus (Dave Darling) |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | led collab |
| Collaborator Contribution | publications |
| Impact | publications |
| Start Year | 2010 |
| Title | GET system with James & Kevin |
| Description | This invention relates to transduction of cargo molecules into living cells, such as protein transduction, in particular a delivery molecule for transduction of a cargo into a cell comprising: a cargo-binding molecule and/or a cargo; a glycosaminoglycan (GAG) binding element, which is capable of binding to GAG on the surface of the cell; and a protein transduction domain. Methods of transduction, methods of producing or modifying cargo for transduction, delivery molecules for transduction and methods of treatment using transduction, or using transduced cells are also provided. |
| IP Reference | WO2015092417 |
| Protection | Patent application published |
| Year Protection Granted | 2015 |
| Licensed | No |
| Impact | Scientific development with view to licensing. |
| Title | New synthetic culture surfaces for human embryonic stem cells |
| Description | Patent filed to cover new synthetic substrate to culture human embryonic stem cells |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | Negotiations with major plasticware companies in progress through Nottingham's tech trasnfer office |
| Title | Raman |
| Description | optical spectra for cardiomyocytes using Raman microspectroscopy defined |
| IP Reference | GB1018628.6 |
| Protection | Patent application published |
| Year Protection Granted | 2010 |
| Licensed | Commercial In Confidence |
| Impact | linking into partners within the Bioprocess Research Industry Club |
| Description | BBC East Midlands Today - BHF education on heart disease |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with BBC East Midlands Today to educate on importance for research for heart disease |
| Year(s) Of Engagement Activity | 2016 |
| Description | BBC News |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | more interest in lab / education interest in lab / education |
| Year(s) Of Engagement Activity | 2015 |
| Description | BBC radio Nottingham (Heart-light) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Public engaged on new research grant |
| Year(s) Of Engagement Activity | 2015 |
| Description | BHF - Welcome booklet imaging (Sorrel Bunting Oct 2016) |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Information booklet commissioned by BHF and Wellcome Trust to support research against cardiovascular disease |
| Year(s) Of Engagement Activity | 2016 |
| Description | BHF Visit Outreach for Sorrel Bunting (Nov 2016) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | Group of 20 workers from BHF, including shop-runners, fund raisers, office workers |
| Year(s) Of Engagement Activity | 2016 |
| Description | BHF news advert / article |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Paper Presentation |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Advertising in national newspaper to early to tell but part of BHF effort to continually raise funds |
| Year(s) Of Engagement Activity | 2012 |
| Description | BHF public information booklet on research |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Paper Presentation |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | British people with interest in heart disease engaged to early to be determined but acts as part of continual BHF effort to raise funds |
| Year(s) Of Engagement Activity | 2012 |
| Description | BIRAX press release in May 2016 to promote heart therapies |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Promoting research into treatments for heart disease |
| Year(s) Of Engagement Activity | 2016 |
| Description | Blog in Huffington post |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Blog in Huffington Post which promoted new grant - global reach |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.huffingtonpost.co.uk/simon-gillespie/valentines-day_b_6669914.html?utm_hp_ref=science |
| Description | Channel 4 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Featured on channel 4 documentary disseminated to wider public |
| Year(s) Of Engagement Activity | 2010 |
| Description | Heart Res UK case study for AMRC (Nov 2016) |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | Case study / newsletter from Heart Research UK grant to educate on need for new medicines for heart disease |
| Year(s) Of Engagement Activity | 2016 |
| Description | Invited conference presentation during 2016-2017 reporting period |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented at >20 international conferences in Europe, Middle East, Asia and USA, each having 50 to 500 delegates from professional academic, public, media, patient and industry |
| Year(s) Of Engagement Activity | 2016,2017 |
| Description | Media (as a channel to the public) |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | - Provision of short articles to magazines such as BioWorld International, BBSRC business, Hospital Solutions - Interview with newspapers, such as Daily Mail, Telegraph etc organised through the Science Media Centre in London - Interviewed and filmed by BBC Scotland 6 O'clock news and BBC / ITV local news stations Increased public perception and acceptance of the importance of stem cells. Increased application rates from PhD students to our unit |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009 |
| Description | Nottingham press release (EPSRC £6.5m project) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Press release leading to new interactions |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.nottingham.ac.uk/news/pressreleases/2015/august/3d-vision-for-the-next-generation-of-biom... |
| Description | Nottingham press release (heart light) |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Press release on new grant |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.nottingham.ac.uk/news/pressreleases/2015/february/light-sensitive-proteins-could-help-men... |
| Description | Nottingham press release (new biomaterials) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | nottingham press release on new publication. Led to additional funding and interaction |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.nottingham.ac.uk/news/pressreleases/2015/july/new-material-forges-the-way-for-stem-cell-f... |
| Description | Observer & Guardian on Sunday 2014 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Description of research to National newspapers follow up enquiries and public engagement |
| Year(s) Of Engagement Activity | 2014 |
| Description | Public engagement day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | 250 members of the public attended the British Society for Gene Therapy public day in Brighton active engagement and enthusiasm from members of the public |
| Year(s) Of Engagement Activity | 2011 |
| Description | Sara Pijuangalito (Times article on stem cell expansion, July 2016) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | New methods for stem cell manufacture picked up by The Times Newspaper |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.thetimes.co.uk/article/scientists-discover-way-to-mass-produce-stem-cells-cxr2mcqgc |
| Description | SkyNews |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Watched by 13 million people interest in research group |
| Year(s) Of Engagement Activity | 2015 |
| Description | observer |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview with Observer on hiPSC-based cardiovascular work national press and engagement with public |
| Year(s) Of Engagement Activity | 2011 |
| Description | public engagement day |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The engagement day was attended by approx 250 members of the public good attendance and feedback will mean the event will be run again in 2013. |
| Year(s) Of Engagement Activity | 2011 |