Magnetic Resonance Imaging In Dementia: Distinguishing Diseases and Measuring Progression

Lead Research Organisation: University College London
Department Name: UNLISTED

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

10 25 50
 
Description ADRD, member
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
 
Description A genetic study of 500 deeply phenotyped members of the MRC NSHD 1946 birth cohort
Amount £219,355 (GBP)
Funding ID UCC14181 
Organisation Brain Research Trust (BRT) 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2016 
End 03/2019
 
Description ARUK Drug Discovery Institute
Amount £8,800,000 (GBP)
Funding ID ARUK-2015DDI-UCL 
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2014 
End 08/2020
 
Description ARUK: Support for Rare Dementias and Support Groups
Amount £23,000 (GBP)
Funding ID ARUK-2015-RDSG 
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2016 
End 01/2017
 
Description Alzheimer Society - clinical fellowship awarded to Antoinette O Connor
Amount £206,040 (GBP)
Funding ID 439 
Organisation Alzheimer’s Society 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2018 
End 04/2022
 
Description Alzheimer's Society, Whole Genome Sequencing in patients and families with dementia
Amount £99,995 (GBP)
Funding ID 263 AS-PG-15-037 
Organisation Alzheimer’s Society 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2016 
End 12/2017
 
Description BRC award to UCL/H (Dementia Theme)
Amount £5,000,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 04/2017 
End 04/2022
 
Description Brain Research Trust
Amount £219,355 (GBP)
Organisation Brain Research Trust (BRT) 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2016 
End 03/2019
 
Description Drake Foundation: Effects of head injury the NSHD 1946 birth cohort.
Amount £60,852 (GBP)
Organisation The Drake Foundation 
Sector Charity/Non Profit
Country Unknown
Start 04/2017 
End 04/2019
 
Description EPRSC C-PLACID (Computational Platform for Assessment of Cognition in Dementia
Amount £1,430,000 (GBP)
Funding ID EP/M006093/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 01/2015 
End 12/2017
 
Description EPSRC Computational Methods of Neurodegenerative Disease progression
Amount £59,290,999 (GBP)
Funding ID EP/J020990/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 03/2013 
End 02/2016
 
Description Europond - European Progression of Neurodegenerative Disease Initiative
Amount £1,069,569 (GBP)
Funding ID H2020-PHC-2014-2015-666992 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2016 
End 12/2019
 
Description Improving Prevention Trials in AD through Imaging - Dave Cash and Nick Fox
Amount £250,000 (GBP)
Funding ID 261 (AS-PG-15-025 
Organisation Alzheimer’s Society 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2016 
End 02/2018
 
Description MRC CRI next generation MRI brain imaging platform for dementia research
Amount £1,100,000 (GBP)
Funding ID MR/M009106/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description MRC Senior Clinical Fellowship
Amount £1,175,320 (GBP)
Funding ID GO 601846 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2007 
End 08/2012
 
Description MRC UK Dementia Research Institute Award - Dementia Bench to Bedside
Amount £6,000,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2017 
End 10/2022
 
Description NIHR Rare Disease Translational Research Collaboration
Amount £496,630 (GBP)
Funding ID BRC127/NS/NW/5992 
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 11/2013 
End 04/2018
 
Description Rosetrees: Detecting and tracking brain changes in early Alzheimer's Disease
Amount £248,130 (GBP)
Funding ID M668-CD1 
Organisation Rosetrees Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2017 
End 08/2020
 
Description UK GENFI
Amount £2,613,582 (GBP)
Funding ID MR/M023664/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2015 
End 04/2020
 
Description Wellcome Trust Clinical Research Training Fellowship
Amount £174,791 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Bloomsbury Centre
Sector Academic/University
Country United Kingdom
Start 04/2016 
End 03/2019
 
Description Wellcome Trust Novel Biomarker Platform
Amount £120,000 (GBP)
Funding ID 108457/Z/15/Z 
Organisation Wellcome Trust 
Department Wellcome Trust Bloomsbury Centre
Sector Academic/University
Country United Kingdom
Start 07/2015 
End 07/2017
 
Description Wellcome Trust: Created out of /mind, shaping perceptions of Dementia through Art
Amount £715,200 (GBP)
Funding ID 200783/Z/16/Z 
Organisation Wellcome Trust 
Department Wellcome Trust Bloomsbury Centre
Sector Academic/University
Country United Kingdom
Start 10/2016 
End 07/2018
 
Description Wolfson Foundation: Ageing Cohort
Amount £887,193 (GBP)
Organisation The Wolfson Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2013 
End 03/2019
 
Description Wolfson Foundation: Early intervention in Neurodegeneration
Amount £20,000,000 (GBP)
Funding ID PR/ylr/18575 
Organisation The Wolfson Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2012 
End 03/2018
 
Title MIRIAD 
Description Longitudinal series of MRI scans in AD and controls with associated anonymised clinical material 
Type Of Material Biological samples 
Year Produced 2012 
Provided To Others? Yes  
Impact A conference presentation where seven international groups analysed the datasets and a paper is planned 
 
Title MRI scans in ADNI database 
Description Publically available pre-processed MR scans of subjects with AD (n=200); MCI (n=400) and normal elderly (n=200). Also provided analyses - brain volumes and rates of atrophy - freely available. 
Type Of Material Biological samples 
Year Produced 2006 
Provided To Others? Yes  
Impact Numerous publications (see ADNI) - the data may contribute to more efficient clinical trials in AD 
 
Description ADNI 
Organisation Mayo Clinic
Country United States 
Sector Charity/Non Profit 
PI Contribution Helped design the study and the preparatory phase Image Analyses Intellectual input
Collaborator Contribution Data Intellectual inputData Intellectual input Data processing
Impact Publicity The ADNI - Alzheimer's Disease Neuroimaging Initiative is the largest study of its kind ($60million) and I (my group) am the only non-US member of the consortium ADNI has been covered in several general readership journals and papers and on the AlzForum ADNI has been the focus of special issues in several journals Publications include PMID: 20620665; PMID: 20451869; PMID: 20230901; PMID: 19760240; PMID: 19477282 PMID: 19437497 PMID: 19339253 PMID: 18202106 PMID: 18063391 PMID: 16480900 PMID: 19042931 PMID: 18378167
 
Description ADNI 
Organisation University of California, San Francisco
Country United States 
Sector Academic/University 
PI Contribution Helped design the study and the preparatory phase Image Analyses Intellectual input
Collaborator Contribution Data Intellectual inputData Intellectual input Data processing
Impact Publicity The ADNI - Alzheimer's Disease Neuroimaging Initiative is the largest study of its kind ($60million) and I (my group) am the only non-US member of the consortium ADNI has been covered in several general readership journals and papers and on the AlzForum ADNI has been the focus of special issues in several journals Publications include PMID: 20620665; PMID: 20451869; PMID: 20230901; PMID: 19760240; PMID: 19477282 PMID: 19437497 PMID: 19339253 PMID: 18202106 PMID: 18063391 PMID: 16480900 PMID: 19042931 PMID: 18378167
 
Description Amsterdam 
Organisation University of Amsterdam
Country Netherlands 
Sector Academic/University 
PI Contribution Processing of data, analyses and intellectual input
Collaborator Contribution Data sharing
Impact Publications entered under G0601846 PMID: 19618189 PMID: 19297506
 
Description MRI and Biomarkers in HD 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of Software Techniques Advice and Intellectual Input Image analyses
Collaborator Contribution Data Clinical input Joint students
Impact Grants - including the TRACK HD internaional collaboration PhDs - Susie Henley awarded 2008 Ed Wild awarded 2009 Publications - PMID: 20461806; PMID: 20150305; PMID: 20037137; PMID: 19955112 PMID: 19646924 PMID: 19523522 PMID: 19266143 PMID: 19243073 PMID: 18407301 PMID: 16924028 Multidisciplinary - neurologists, psychologists, computer scientists, physicists
 
Description MRI in MS 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of software Training Advice and intellectual input
Collaborator Contribution Intellectual input Data
Impact Pub lications PMID: 17238871 PMID: 16596564 PMID: 17940723
 
Title MIDAS 
Description software designed to compare brain atrophy from scans provided by research patients - The standard reference for MIDAS is: Freeborough PA, Fox NC, Kitney RI. Interactive algorithms for the segmentation and quantitation of 3-D MRI brain scans. Computer Methods and Programs in Biomedicine 1997; 53: 15-25 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted
Licensed Yes
Impact Huge impact on all clinical trials conducted by my department since MIDAS was introduced
 
Title Boundary Shift Integral 
Description An improved method for measuring rates of brain atrophy 
Type Diagnostic Tool - Imaging
Current Stage Of Development Small-scale adoption
Year Development Stage Completed 2009
Development Status Under active development/distribution
Impact Adopted in a number (>20 since 1996) of international clinical trials 
 
Description Article in the Guardian and The Observer: Does our immune system hold the key to beating Alzheimer's disease 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact N/A
Year(s) Of Engagement Activity 2019
URL https://www.theguardian.com/society/2019/mar/03/alzheimers-disease-immune-system-immunotherapy-vacci...
 
Description Futurelearn course: MOOC Dementia and the arts: Sharing practice, developing understanding and enhancing lives 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact N/A
Year(s) Of Engagement Activity 2019
URL https://www.futurelearn.com/courses/dementia-arts
 
Description Interviews and material for Alz Soc web site 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact I have been interviewed for the web sites of the Alzheimer's Society and Alzheimer's Research UK - these sites are very frequently accessed
I have provided material - images and text for both websites

Increased awareness
Year(s) Of Engagement Activity 2007,2008,2009,2010,2011
 
Description Neurocentral video: Dementia, biomarkers and an extraordinary study: Nick Fox on Insight 46 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact N/A
Year(s) Of Engagement Activity 2019
URL https://www.neuro-central.com/2017/07/05/dementia-biomarkers-extraordinary-study-nick-fox-insight-46...
 
Description PCA Support Group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact Presented research

Participation in research
Year(s) Of Engagement Activity 2008
 
Description Pick's Disease Support Group Annual Meetings 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact Annual meetings attract about 60 careres and interested lay members of the public

Repeat requests for speakers at the PDSG
Greater involvement in research
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010
 
Description Schools Visit to CMIC UCL 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach Regional
Primary Audience Schools
Results and Impact As part of an EPSRC Science into Schools project (PI - Derek Hill) I presented my research showing how physics and science can contribute to medical research

Not evaluated formally but feedback from the school was increased interest in science
Year(s) Of Engagement Activity 2007
 
Description Web-based series of articles 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Health professionals
Results and Impact Interviewed on my research on the ARF website as part of a series on Familial AD

Increased awareness - this is very frequently accessed site and newsletter
Year(s) Of Engagement Activity 2007,2009