Characterisation of the role of T cells in the pathogeesis of atopic dermatitis

Lead Research Organisation: University of Oxford
Department Name: Unknown

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

10 25 50

publication icon
Ardern-Jones MR (2007) Bacterial superantigen facilitates epithelial presentation of allergen to T helper 2 cells. in Proceedings of the National Academy of Sciences of the United States of America

publication icon
Aslam A (2006) Defining the T cell antigen proteome of wasp venom. in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

publication icon
Bateman EA (2008) Identification of an immunodominant region of Fel d 1 and characterization of constituent epitopes. in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

publication icon
Black AP (2003) The role of p53 in the immunobiology of cutaneous squamous cell carcinoma. in Clinical and experimental immunology

publication icon
Black AP (2009) Immune evasion during varicella zoster virus infection of keratinocytes. in Clinical and experimental dermatology

 
Description British Medical Association
Amount £35,000 (GBP)
Organisation British Medical Association (BMA) 
Sector Learned Society
Country United Kingdom
Start 10/2012 
End 09/2014
 
Description Janssen collaborative research grant
Amount $1,600,000 (USD)
Organisation Johnson & Johnson 
Department Janssen Pharmaceuticals
Sector Private
Country United States
Start 10/2013 
End 09/2015
 
Description MRC Experimental Medicine 2
Amount £380,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2009 
End 09/2012
 
Description MRC/UCB Antibody Discovery Initiative
Amount £250,000 (GBP)
Funding ID MC_EX_MR/R022550/1 
Organisation University of Oxford 
Sector Academic/University
Country United Kingdom
Start 02/2019 
End 12/2019
 
Title Allergen-specific T cells 
Description Allergen-specific T cells were derived from human peripheral blood and used to show an interaction with S.aureus. This has lead to the award of an MRC Experimental Medicine 2 grant for a proof of concept clinical trial. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2008 
Provided To Others? Yes  
Impact many outputs - see relevant sections 
 
Title HLA peptide tetrameric complexes 
Description I was involved in the later stages of HLA peptide tetrameric complex development and refinement of their use (first developed by John Altman, Mark Davis, Andrew McMichael, John Bell et al) and their application to the study of human disease 
Type Of Material Technology assay or reagent 
Year Produced 2006 
Provided To Others? Yes  
Impact Vast number of publications have now used the technology 
 
Description Andrew McKenzie LMB Cambridge 
Organisation Medical Research Council (MRC)
Department MRC Laboratory of Molecular Biology (LMB)
Country United Kingdom 
Sector Public 
PI Contribution We are working with Andrew McKenzie to identify nuocytes in human and model skin and relate to clinical disease. we provide knowhow and expertise for access to human skin cells.
Collaborator Contribution Andrew McKenzie provides knowhow and expertise for access to model skin
Impact new collaboration
Start Year 2011
 
Description Biomedical Research centre Oxford 
Organisation University of Oxford
Department Nuffield Department of Clinical Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution We provided many of the samples and technology for analysis of samples using Biomedical Research Centre equipment.
Collaborator Contribution Access to equipment and individuals
Impact Many outputs as detailed in relevant sections
Start Year 2007
 
Description Branch Moody Harvard 
Organisation Harvard University
Department Harvard Medical School
Country United States 
Sector Academic/University 
PI Contribution We collaborate on CD1a-restricted T cell responses. We have contributed ideas, samples, experimental work and technical advances.
Collaborator Contribution We collaborate on CD1a-restricted T cell responses. Branch Moody and his team have contributed ideas, samples, experimental work and technical advances.
Impact Multiple publications and conference presentations
Start Year 2012
 
Description Judy Breuer 
Organisation University College London
Department MRC Centre for Medical Molecular Virology
Country United Kingdom 
Sector Public 
PI Contribution Analyses of T cell responses to varicella zoster virus
Collaborator Contribution Provision of samples and analyses
Impact see relevant sections
Start Year 2008
 
Description Paul Klenerman VZV 
Organisation Medical Research Council (MRC)
Department MRC Molecular Haematology Unit
Country United Kingdom 
Sector Public 
PI Contribution Analysis of varicella zoster virus specific immune respoonses after vaccination
Collaborator Contribution Access to samples and discussions.
Impact Publications and presentations
Start Year 2008
 
Description Transduction of TCR 
Organisation University College London
Department Division of Infection and Immunity
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of T cell clones
Collaborator Contribution Help with cloning TCR into primary T cells
Impact Still early stages
Start Year 2009
 
Description University of Sri Jayawardanapura 
Organisation University of Sri Jayawardanapura
Country Sri Lanka 
Sector Academic/University 
PI Contribution Analyses of samples
Collaborator Contribution Contribution of samples and some analyses
Impact see relevant sections
Start Year 2008
 
Title Idea that combined allergen and anti-bacterial approaches may benefit patients with atopic disease 
Description We observed that staphylococcal superantigen facilitates antigen presentation of allergen by epithelial cells. This potentially explains a clinical observation seen in individuals with atopic dermatitis, that flares of disease are often associated with infection. The underlying mechanisms were characterised. I believe this is important for understanding of disease and for the development of new treatment approaches (recent award of MRC Experimental Medicine 2 funding to take this into a proof-of-principle clinical trial). 
Type Therapeutic Intervention - Drug
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2007
Development Status Under active development/distribution
Impact We hope that this will provide patient benefit 
 
Description CRN Podcast 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Podcast highlighting medical problems in dermatology and our strategies for developign new approaches to treatment.
Year(s) Of Engagement Activity 2019
 
Description National Science Week 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Approximately 150 members of public attended lectures and displays

I have many school children who wish to have lab attachments
Year(s) Of Engagement Activity 2009,2010