Cognitive, developmental and genetic approach to emotional disorders in childhood

Lead Research Organisation: King's College London
Department Name: Unlisted

Abstract

Genetic research has shown that there is a shared genetic vulnerability to anxiety and depression. We know that both these disorders develop as a result of experiencing specific negative experiences and we have strong data as to what these experiences are. However, we know very little about how the general genetic vulnerability is expressed.

This study proposes that the genetic vulnerability will alter how people process information and think about the world or themselves (cognition), making them more sensitive to stress.

This study includes measures of cognition and stress within a twin design, which disentangles genes and environment. The study will be a collaboration between two internationally renowned groups: behavioural genetics of mood disorders (led by Prof. Peter McGuffin) and cognition in anxiety disorders (led by Prof. David Clark).

If we can find measures of thinking style that are inherited and that, given specific negative events, lead to anxiety and depression it will be a major advance in our understanding of the development of these debilitating disorders.

The long-term goal is to predict children who are at risk, enabling us eventually to undertake preventative training with such children and their families.

Technical Summary

OBJECTIVES
A four factor developmental cognitive genetic model of emotional disorders is proposed in which a general gentic vulnerability (factor 1) to anxiety and depression results in biased information processing and cognition (factor 2). Interactions with specific negative environmental influences (factor 3) are associated with specific types of symptons (factor 4). It is hypothsised that information processing is heritable, and that the genetic influence will be general to the development of all aspects of emotion related cognition. In contrast, it is propased that the environmental influences will laregely be specific to individual aspects of cognition and specific types of symptoms.

DESIGN
THe sample will be selected from the MRC funded Twins‘ Early development Study. Mother-reported emotional symtoms at 7 years will be used to select a high anxiety group (top 5% N=250 pairs) and unselected controls (M=50 pairs) who will be visited at ages 8 and 10 years.

CELLS
DNA is obtained fromcheek cells.

APPROACH & MEASUREMENT
Within the behavioural genetic design a cognitive psychological perspective will be taken to assess biased information processing and dysfunctional cognitions, negative environmental influences, and anxiety and depression symptoms.

OUTCOME
Bivariate genetic analyses will be used to establish the role of genes and the environment on the relationship between cognition and symptoms. Longitudinal behavioural genetic analyses will examine the role of cognition, genes and the environment on the development of anxiety and depression in middle childhood. Associtions between candidate genes and cognition will be explored, cognitive functioning being seen as a more proximal indicator of genetic risk than symptoms.

Publications

10 25 50

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Barclay NL (2011) Sleep quality and diurnal preference in a sample of young adults: associations with 5HTTLPR, PER3, and CLOCK 3111. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

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Bolton D (2009) Normative childhood repetitive routines and obsessive compulsive symptomatology in 6-year-old twins. in Journal of child psychology and psychiatry, and allied disciplines

 
Description British Academy
Amount £5,927 (GBP)
Organisation The British Academy 
Sector Academic/University
Country United Kingdom
Start 01/2007 
End 12/2007
 
Description ESRC, Small Project Grant
Amount £80,187 (GBP)
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 03/2007 
End 02/2008
 
Description Exploring the development of anxiety in young people: a combined social, genetic and cognitive approach: PhD studentship
Amount £82,000 (GBP)
Funding ID 1013456 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start  
 
Description Familial transmission of emotional development: A child of twins approach.
Amount £195,440 (GBP)
Organisation The Leverhulme Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2012 
End 03/2015
 
Description Longitudinal Population Studies Grant: 'TwinsUK (2019-2023) - An Epidemiological and Genomic Resource
Amount £3,000,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 12/2023
 
Description MRC New Investigator Research Grant (G0901874)
Amount £479,968 (GBP)
Funding ID G0901874 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2010 
End 10/2013
 
Description MRC Population Health Scientist Fellowship
Amount £270,776 (GBP)
Funding ID MR/K021281/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 07/2013 
End 07/2016
 
Description NHMRC Fellowship
Amount £440,802 (GBP)
Organisation National Health and Medical Research Council 
Sector Public
Country Australia
Start 01/2008 
End 12/2013
 
Description Post-Doctoral Fellowship: The Role of Antisocial friends in the Development of Antisocial behaviour During Adolescence
Amount £85,328 (GBP)
Funding ID ES/I036524/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 06/2011 
End 06/2012
 
Description Psychiatry Research Trust (at the IoP) DNA methylation and adolescent depression: An MZ differences study
Amount £47,800 (GBP)
Organisation King's College London 
Department Psychiatry Research Trust
Sector Charity/Non Profit
Country United Kingdom
Start 09/2011 
End 09/2013
 
Description Student Bursary to attend British Psychological Society Developmental section conference.
Amount £300 (GBP)
Organisation British Psychological Society (BPS) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description TwinsUK (2019-2023) - An Epidemiological and Genomic Resource
Amount £3,000,000 (GBP)
Funding ID 212904/Z/18/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 06/2022
 
Title ECHO study dataset 
Description The study has resulted in a rich dataset which is being analysed by a number of researchers outside the original research team. Measures include anxiety and depression, related cognitions, measures of environmental stress. This is a highly unusual dataset as face-to-face data of this kind is not usually collected in such large numbers (300 twin pairs at 2 time-points). Analysis by other researchers is in collaboration with us only as ethical consent was only given for the data to be used by the research team. Nonetheless there are a considerable number of external collaborators involved now. 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2006 
Provided To Others? Yes  
Impact It has allowed extensive analysis of questions relating to the development of anxiety and depression in young people. 
 
Title G1219 study dataset 
Description We have contacted over 1000 twin and sibling pairs over a 7 year period spanning adolescence and young adulthood. A wide array of measures have been collected including anxiety, depression, sleep problems, externalizing behaviour, cognitive biases, environmental stress, DNA, peer and family relationships. 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2006 
Provided To Others? Yes  
Impact Extensive analyses and publications - see publications list. 
 
Title ECHO study dataset 
Description The study has resulted in a rich dataset which is being analysed by a number of researchers outside the original research team. Measures include anxiety and depression, related cognitions, measures of environmental stress. This is a highly unusual dataset as face-to-face data of this kind is not usually collected in such large numbers (300 twin pairs at 2 time-points). Analysis by other researchers is in collaboration with us only as ethical consent was only given for the data to be used by the research team. Nonetheless there are a considerable number of external collaborators involved now. 
Type Of Material Database/Collection of data 
Year Produced 2006 
Provided To Others? Yes  
Impact Please see publications associated with this award. 
 
Title G1219 dataset 
Description We have contacted over 1000 twin and sibling pairs over a 7 year period spanning adolescence and young adulthood. A wide array of measures have been collected including anxiety, depression, sleep problems, externalizing behaviour, cognitive biases, environmental stress, DNA, peer and family relationships. 
Type Of Material Database/Collection of data 
Year Produced 2006 
Provided To Others? Yes  
Impact Please see all publications relating to this award. 
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation Columbia University
Country United States 
Sector Academic/University 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation Creighton University
Country United States 
Sector Academic/University 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation Hunter College
Country United States 
Sector Academic/University 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation McLean Hospital
Country United States 
Sector Hospitals 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation National Institutes of Health (NIH)
Department National Institute of Mental Health (NIMH)
Country United States 
Sector Public 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation NewYork-Presbyterian Hospital
Country United States 
Sector Hospitals 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation Penn State University
Country United States 
Sector Academic/University 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation Tel Aviv University
Department Psychology Department (TAU)
Country Israel 
Sector Academic/University 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation Tel Aviv University
Department Psychology Department (TAU)
Country Israel 
Sector Academic/University 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation University College Dublin
Department School of Psychology
Country Ireland 
Sector Academic/University 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation University of Amsterdam
Country Netherlands 
Sector Academic/University 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation University of California, San Francisco
Country United States 
Sector Academic/University 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation University of Colorado Denver
Department School of Medicine Colorado
Country United States 
Sector Academic/University 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Attention Bias Modification Treatment: International Consortium 
Organisation University of Sao Paulo
Department OCD Spectrum Disorders Clinic
Country Brazil 
Sector Academic/University 
PI Contribution I will undertake all DNA extraction and genotyping on these samples.
Collaborator Contribution I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety. I will be sent DNA samples from children taking part in an intrernational trial looking at the efficacy of attention bias modification as a treatment for child anxiety.
Impact Only just started
Start Year 2011
 
Description Children of Twins collaboration 
Organisation Karolinska Institute
Department Department of Medical Epidemiology and Biostatistics
Country Sweden 
Sector Academic/University 
PI Contribution I have sought and won funding to pay for a post-doctoral research assistant to analyse these datasets jointly. I will supervise this work.
Collaborator Contribution I am being granted access to a large dataset of adolescent twins and also of twin parents to analyse alongside my own adolescent twin sample. I am being granted access to a large dataset of adolescent twins and also of twin parents to analyse alongside my own adolescent twin sample.
Impact Grant funding from the Leverhulme Trust (see Further Funding section). Funding will commence in 2012.
Start Year 2010
 
Description Children of Twins collaboration 
Organisation Penn State University
Department Department of Psychology
Country United States 
Sector Academic/University 
PI Contribution I have sought and won funding to pay for a post-doctoral research assistant to analyse these datasets jointly. I will supervise this work.
Collaborator Contribution I am being granted access to a large dataset of adolescent twins and also of twin parents to analyse alongside my own adolescent twin sample. I am being granted access to a large dataset of adolescent twins and also of twin parents to analyse alongside my own adolescent twin sample.
Impact Grant funding from the Leverhulme Trust (see Further Funding section). Funding will commence in 2012.
Start Year 2010
 
Description Genetics of Child Anxiety Collaboration 
Organisation Aarhus University
Country Denmark 
Sector Academic/University 
PI Contribution We are extracting and housing the DNA and are currently genotyping various markers on the sample we have collected to date.
Collaborator Contribution They are gathering DNA on subjects going through their clinical trials for child anxiety. We are analysing this DNA.
Impact My collaborator in Sydney has been awarded a fellowship from the Australian Research Council on which I am a named applicant.
Start Year 2007
 
Description Genetics of Child Anxiety Collaboration 
Organisation Florida International University (FIU)
Country United States 
Sector Academic/University 
PI Contribution We are extracting and housing the DNA and are currently genotyping various markers on the sample we have collected to date.
Collaborator Contribution They are gathering DNA on subjects going through their clinical trials for child anxiety. We are analysing this DNA.
Impact My collaborator in Sydney has been awarded a fellowship from the Australian Research Council on which I am a named applicant.
Start Year 2007
 
Description Genetics of Child Anxiety Collaboration 
Organisation Free University of Amsterdam
Country Netherlands 
Sector Academic/University 
PI Contribution We are extracting and housing the DNA and are currently genotyping various markers on the sample we have collected to date.
Collaborator Contribution They are gathering DNA on subjects going through their clinical trials for child anxiety. We are analysing this DNA.
Impact My collaborator in Sydney has been awarded a fellowship from the Australian Research Council on which I am a named applicant.
Start Year 2007
 
Description Genetics of Child Anxiety Collaboration 
Organisation Macquarie University
Department Department of Psychology
Country Australia 
Sector Academic/University 
PI Contribution We are extracting and housing the DNA and are currently genotyping various markers on the sample we have collected to date.
Collaborator Contribution They are gathering DNA on subjects going through their clinical trials for child anxiety. We are analysing this DNA.
Impact My collaborator in Sydney has been awarded a fellowship from the Australian Research Council on which I am a named applicant.
Start Year 2007
 
Description Genetics of Child Anxiety Collaboration 
Organisation Medical Research Council (MRC)
Department MRC Cognition and Brain Sciences Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution We are extracting and housing the DNA and are currently genotyping various markers on the sample we have collected to date.
Collaborator Contribution They are gathering DNA on subjects going through their clinical trials for child anxiety. We are analysing this DNA.
Impact My collaborator in Sydney has been awarded a fellowship from the Australian Research Council on which I am a named applicant.
Start Year 2007
 
Description Genetics of Child Anxiety Collaboration 
Organisation National Institutes of Health (NIH)
Department National Institute of Mental Health (NIMH)
Country United States 
Sector Public 
PI Contribution We are extracting and housing the DNA and are currently genotyping various markers on the sample we have collected to date.
Collaborator Contribution They are gathering DNA on subjects going through their clinical trials for child anxiety. We are analysing this DNA.
Impact My collaborator in Sydney has been awarded a fellowship from the Australian Research Council on which I am a named applicant.
Start Year 2007
 
Description Genetics of Child Anxiety Collaboration 
Organisation Ruhr University Bochum
Country Germany 
Sector Academic/University 
PI Contribution We are extracting and housing the DNA and are currently genotyping various markers on the sample we have collected to date.
Collaborator Contribution They are gathering DNA on subjects going through their clinical trials for child anxiety. We are analysing this DNA.
Impact My collaborator in Sydney has been awarded a fellowship from the Australian Research Council on which I am a named applicant.
Start Year 2007
 
Description Genetics of Child Anxiety Collaboration 
Organisation University of Basel
Country Switzerland 
Sector Academic/University 
PI Contribution We are extracting and housing the DNA and are currently genotyping various markers on the sample we have collected to date.
Collaborator Contribution They are gathering DNA on subjects going through their clinical trials for child anxiety. We are analysing this DNA.
Impact My collaborator in Sydney has been awarded a fellowship from the Australian Research Council on which I am a named applicant.
Start Year 2007
 
Description Genetics of Child Anxiety Collaboration 
Organisation University of Bergen
Country Norway 
Sector Academic/University 
PI Contribution We are extracting and housing the DNA and are currently genotyping various markers on the sample we have collected to date.
Collaborator Contribution They are gathering DNA on subjects going through their clinical trials for child anxiety. We are analysing this DNA.
Impact My collaborator in Sydney has been awarded a fellowship from the Australian Research Council on which I am a named applicant.
Start Year 2007
 
Description Genetics of Child Anxiety Collaboration 
Organisation University of Groningen
Country Netherlands 
Sector Academic/University 
PI Contribution We are extracting and housing the DNA and are currently genotyping various markers on the sample we have collected to date.
Collaborator Contribution They are gathering DNA on subjects going through their clinical trials for child anxiety. We are analysing this DNA.
Impact My collaborator in Sydney has been awarded a fellowship from the Australian Research Council on which I am a named applicant.
Start Year 2007
 
Description Genetics of Child Anxiety Collaboration 
Organisation University of Reading
Department School of Psychology and Clinical Language Science
Country United Kingdom 
Sector Academic/University 
PI Contribution We are extracting and housing the DNA and are currently genotyping various markers on the sample we have collected to date.
Collaborator Contribution They are gathering DNA on subjects going through their clinical trials for child anxiety. We are analysing this DNA.
Impact My collaborator in Sydney has been awarded a fellowship from the Australian Research Council on which I am a named applicant.
Start Year 2007
 
Description International Study of Genetic Factors in Exposure Treatments of Anxiety Disorders 
Organisation Ruhr University Bochum
Department Faculty of Psychology
Country Germany 
Sector Academic/University 
PI Contribution I am leading the genetic aspects of this project. All DNA samples will be sent to me and all genotyping and RNA analysis will be done within my group.
Collaborator Contribution They are conducting a large study of exposure therapy in adults with phobias and have asked me to lead the genetic component of the project. I will therefore have DNA on psychological treatment response, and funding to genotype, from a large sample of adults which can complement the child sample being obtained within this grant.
Impact We are just beginning to obtain DNA samples now.
Start Year 2010
 
Description Psychiatric Genomics Consortium Anxiety Group 
Organisation Psychiatric Genomics Consortium (PGC)
Country Global 
Sector Learned Society 
PI Contribution I have initiated, along with two other colleagues (Jack Hettema and Jurgen Deckert), an anxiety group for the Psychiatric Genomics Consortium.
Collaborator Contribution The three of us co-Chair this new PGC group
Impact We are working towards our first data freeze later this year, following which we will write our first paper.
Start Year 2017
 
Description 2014 Inaugural Lecture By Prof Thalia Eley- Something old, something new: Disentangling genetic and environmental influences on anxiety and depression 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Inspired discussion among the audience after the presentation.

After the talk, I received a lot of positive feedback of the talk.
Year(s) Of Engagement Activity 2014
 
Description 2014 Lay summary of paper 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 2014 Lay summary of paper, http://medicalresearch.com/mental-health-research/genetic-structures-
Year(s) Of Engagement Activity 2014
URL http://medicalresearch.com/mental-health-research/genetic-structures-
 
Description 2015 Lay summary of paper 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact 2015 Lay summary of paper, https://www.anxiety.org/cbt-cognitive-behavioural-therapy-children-anxiety
Year(s) Of Engagement Activity 2015
URL https://www.anxiety.org/cbt-cognitive-behavioural-therapy-children-anxiety
 
Description Guest speaker, Oslo, Norway 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Spoke for an entire day about the development of anxiety and depression in young people including reviewing the findings of my own research programme in considerable detail.

This led to potential collaborations and raised the profile of this study within the Norwegian child psychology community
Year(s) Of Engagement Activity 2008
 
Description Interview - Genetic Structures Underlying Depression and Anxiety During Development 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact The interview has been shared on several social network sites, and has been well received.

By making the research findings more accessible and less jargon-heavy, this interview makes it easier for lay people to understand the results of our research.
Year(s) Of Engagement Activity 2014
URL http://medicalresearch.com/mental-health-research/genetic-structures-underlying-depression-anxiety-d...
 
Description Invited speaker 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Genetic bases of anxiety disorders. Early Phases of Mental Disorders: Anxiety Disorders, Santander, Spain.

Profile raising in Spain
Year(s) Of Engagement Activity 2006
 
Description Invited speaker - University of Reading Psychology Department 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Health professionals
Results and Impact Talk to a research department with a view to possible collaboration

New collaboration set up.
Year(s) Of Engagement Activity 2007
 
Description Invited speaker, Rome, Italy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Gene-environment interplay: A human developmental perspective on emotional disorders. European Science Foundation workshop, Rome, Italy. One hour lecture.

Led to a return invitation to one of the organisers and potential collaboration
Year(s) Of Engagement Activity 2007
 
Description Invited speaker, San Francisco, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Hazard, heredity and depression. Lecture as part of an invited interdisciplinary session. Society for Research In adolescence. San Francisco, USA.

Collaboratoive discussions that have led to subsequent papers
Year(s) Of Engagement Activity 2006
 
Description Lay summary of a paper 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Eley, T. C., Gregory, A. M., Clark, D. M., & Ehlers, A. (2007). Feeling anxious: A twin study of panic/somatic symptoms, anxiety sensitivity and heart-beat perception in children. Journal of Child Psychology and Psychiatry,12, 1184-1191. Lay summary: http://www.mentalhealthcare.org.uk/research/expanded/index.php?id=44

Increased the profile of this study and this type of work.
Year(s) Of Engagement Activity 2007
 
Description Press coverage generated from 2013 paper - The development of risky attitudes from pre-driving to fully-qualified driving 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The following paper came out in January 2013: http://injuryprevention.bmj.com/content/early/2013/01/14/injuryprev-2012-040551.short. This paper investigated the development of risk-taking and attitudes to speed on the road from pre-driving to fully-qualified driving, subsequently giving rise to media interest (see below).

'Attitudes to Speed Among Learner Drivers Predict Unsafe Driving Once Qualified.' Science Daily: January 23, 2013.
Link: http://www.sciencedaily.com/releases/2013/01/130123195347.htm

The press coverage for this research has since grown, and numerous other news organisations have also reported it. See below:

'Attitudes to speed among learner drivers predict unsafe driving once qualified.' Science Codex: January 24, 2013. Link: http://www.sciencecodex.com/attitudes_to_speed_among_learner_drivers_predict_unsafe_driving_once_qualified-105599

'Attitudes To Speed Among Learner Drivers Predict Unsafe Driving Once Qualified.' Healcon Health News: January 24, 2013. Link: http://healcon.com/health-news/article_attitudes-to-speed-among-learner-drivers-predict-unsafe-driving-once-qualified-images-videos-blogs_AJMxMJR2LJAwKmZlAmx2Zj==.htm#!prettyPhoto[iframe]/0/

'Psychologist will discuss 'risky attitudes' in young drivers.' Road Safety News: May 8, 2013. Link: http://www.roadsafetygb.org.uk/news/2818.html
Year(s) Of Engagement Activity 2013
URL http://www.sciencedaily.com/releases/2013/01/130123195347.htm
 
Description the EDIT lab blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The Emotional Development, Interventions and Treatment (EDIT) lab consists of a group of researchers led by Prof Thalia Eley, Dr Tom McAdams, and Dr Kate Lester. We are based at the Social, Genetic and Developmental Psychiatry Centre, at the Institute of Psychiatry, Psychology & Neuroscience, King's College London. We study the role of genetic, cognitive and environmental factors in the development and treatment of emotional difficulties such as anxiety and depression.
Year(s) Of Engagement Activity 2016
URL https://blogs.kcl.ac.uk/editlab/