Neuroimmune interactions in the brain [Professorship Award]

Lead Research Organisation: University of Manchester
Department Name: Life Sciences

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

Neuroimmune interactions in the brain

Publications

10 25 50

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Clark SR (2008) Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations. in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

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Emsley HC (2005) A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients. in Journal of neurology, neurosurgery, and psychiatry

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Emsley HC (2005) Interleukin-6 and acute ischaemic stroke. in Acta neurologica Scandinavica

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Endres M (2008) Improving outcome after stroke: overcoming the translational roadblock. in Cerebrovascular diseases (Basel, Switzerland)

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Lucas SM (2006) The role of inflammation in CNS injury and disease. in British journal of pharmacology

 
Description Advisory Committee on Science and Research in DoH
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
Impact Member, Advisory Committee on Science and Research in the Department of Health, Chaired by Sir David King. Advised on how to better bring science into all aspects of research in DoH.
 
Description Major revisions to planned legislation on animal experiments
Geographic Reach Europe 
Policy Influence Type Membership of a guidance committee
Impact Co-chair, Bioseciences sector group bringing together academia and industry to revise the European 86/609 planned legislation on animal experiments. Major revisions to the planned legislation.
 
Description Developmental Clinical Studies
Amount £600,000 (GBP)
Funding ID G1001252 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2011 
End 04/2014
 
Description MRC Models of Disease Grant
Amount £640,000 (GBP)
Funding ID G0801040 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 12/2008 
End 08/2012
 
Description Provision of Amgen IL-1RA for clinical studies 
Organisation Amgen Inc
Country United States 
Sector Private 
PI Contribution Carried out pharmacokinetic study to identify optimal dosing regime of IL-1RA in SAH patients.
Collaborator Contribution Provision of IL-1RA for clinical studies
Impact Pharmacokinetic study identified optimal dosing regime of IL-1RA in SAH patients to take forward to test efficacy in further trials. Phase II randomised controlled double blind trial (IL-1RA vs placebo) now completed in SAH patients (analysis in progress).
 
Title New use for IL-1RA to treat neurodegeneration 
Description Collaboration with Amgen Inc. to test the clinical utility of IL-1RA for stroke in man. The first clinical phase II study was completed in 2004. Patent granted initially in US in 2000; other international applications went to grant in 2002, 2003, 2004 and 2008. 
IP Reference WO1993008820 
Protection Patent granted
Year Protection Granted
Licensed No
Impact The data gathered suggest that rhIL-1RA is safe and well tolerated in acute stroke. In addition, rhIL-1RA exhibited biological activity that is relevant to the pathophysiology and clinical outcome of ischaemic stroke. These data demonstrate that rhIL- 1RA has potential as a new therapeutic agent for acute stroke. A pharmacokinetic study of IL-1RA in SAH patients has just been completed(Experimental Medicine grant G0502030).
 
Description All types and numerous locations; numerous examples 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact Numerous scientific, public and policy talks - too many to detail.

Significant press coverage
Year(s) Of Engagement Activity 2006,2007,2008,2009
 
Description Annual STARS lecture, Manchester 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact Annual STARS lecture to ~200 local sixth form and college students.
Title: 'A stroke of bad luck: Understanding brain disease' (targeted at A level Biology).

Not known.
Year(s) Of Engagement Activity 2011
 
Description Frontiers of Science talk, Uni of Manchester 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Frontiers of Science talk delivered to ~150 undergraduate students from 1st year to 3rd year, followed by questions and discussion.
Title: "Flaming brains - new discoveries about brain disease"


No specific impact known.
Year(s) Of Engagement Activity 2011
 
Description Give approx. 10-12 public and schools lectures each year (too numerous to detail) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact Give approx. 10-12 public and schools lectures each year (too numerous to detail)

Not possible to detail specific impacts - aim to increase interest in science, particularly in underprivileged areas. Often receive requests from school students wishing to do work experience in the lab, following a talk at their school (all of whom we aim to accommodate wherever possible).
Year(s) Of Engagement Activity 2009
 
Description Keynote lecture to Schools Science Conference 2011 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Schools
Results and Impact Talk followed by Q&A session. Title: "A stroke of bad luck - new discoveries in the treatment of brain disease". Session: Science is the Future.
Venue : Royal College of Pathologists, London
Audience : 50 secondary year students from years 10-13 and their teachers

No specific impact known.
Year(s) Of Engagement Activity 2011
 
Description Lecture at the University of Birmingham 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Talk title: "A stroke of bad luck: mechanisms and treatments for brain disease". For ~200 Uni staff and students. Followed by questions and discussion.

No specific impact known.
Year(s) Of Engagement Activity 2011
 
Description Numerous scientific, public and policy talks - too many to detail 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Numerous scientific, public and policy talks - too many to detail.

Significant press coverage
Year(s) Of Engagement Activity 2006,2007,2008
 
Description World Stroke Day 2011 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Primary Audience Participants in your research and patient groups
Results and Impact Had several interactive stands/displays showing different aspects of our preclinical research, at World Stroke Day event in Oct. 2011 organised by our clinical colleagues. The audience comprised ~180 stroke patients and their carers, healthcare professionals and associated charities/organisations.

Not known.
Year(s) Of Engagement Activity 2011