Neuroimmune interactions in the brain [Professorship Award]
Lead Research Organisation:
University of Manchester
Department Name: Life Sciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
Neuroimmune interactions in the brain
People |
ORCID iD |
| Nancy Jane Rothwell (Principal Investigator / Fellow) |
Publications
Smith CJ
(2006)
Variability of the systemic acute phase response after ischemic stroke.
in Journal of the neurological sciences
Lucas SM
(2006)
The role of inflammation in CNS injury and disease.
in British journal of pharmacology
Skinner R
(2006)
Psychoneuroimmunology of stroke.
in Neurologic clinics
Selvarajah J
(2009)
Potential surrogate markers of cerebral microvascular angiopathy in asymptomatic subjects at risk of stroke.
in European radiology
Gueorguieva I
(2008)
Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage.
in British journal of clinical pharmacology
Miggin S
(2007)
NF-?B activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1
in Proceedings of the National Academy of Sciences
Emsley HC
(2005)
Interleukin-6 and acute ischaemic stroke.
in Acta neurologica Scandinavica
Clark SR
(2008)
Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations.
in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Watson PM
(2007)
Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons.
in Molecular and cellular neurosciences
Hutchinson PJ
(2007)
Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra.
in Journal of neurotrauma
Endres M
(2008)
Improving outcome after stroke: overcoming the translational roadblock.
in Cerebrovascular diseases (Basel, Switzerland)
Emsley HC
(2007)
Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production.
in BMC neurology
Bano D
(2005)
Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity.
in Cell
Dénes A
(2010)
Chronic systemic infection exacerbates ischemic brain damage via a CCL5 (regulated on activation, normal T-cell expressed and secreted)-mediated proinflammatory response in mice.
in The Journal of neuroscience : the official journal of the Society for Neuroscience
Emsley HC
(2005)
A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients.
in Journal of neurology, neurosurgery, and psychiatry
| Description | Advisory Committee on Science and Research in DoH |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Member, Advisory Committee on Science and Research in the Department of Health, Chaired by Sir David King. Advised on how to better bring science into all aspects of research in DoH. |
| Description | Major revisions to planned legislation on animal experiments |
| Geographic Reach | Europe |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Co-chair, Bioseciences sector group bringing together academia and industry to revise the European 86/609 planned legislation on animal experiments. Major revisions to the planned legislation. |
| Description | Developmental Clinical Studies |
| Amount | £600,000 (GBP) |
| Funding ID | G1001252 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2011 |
| End | 04/2014 |
| Description | MRC Models of Disease Grant |
| Amount | £640,000 (GBP) |
| Funding ID | G0801040 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2008 |
| End | 08/2012 |
| Description | Provision of Amgen IL-1RA for clinical studies |
| Organisation | Amgen Inc |
| Country | United States |
| Sector | Private |
| PI Contribution | Carried out pharmacokinetic study to identify optimal dosing regime of IL-1RA in SAH patients. |
| Collaborator Contribution | Provision of IL-1RA for clinical studies |
| Impact | Pharmacokinetic study identified optimal dosing regime of IL-1RA in SAH patients to take forward to test efficacy in further trials. Phase II randomised controlled double blind trial (IL-1RA vs placebo) now completed in SAH patients (analysis in progress). |
| Title | TREATMENT OF NEUROLOGICAL CONDITIONS BY AN INTERLEUKIN-1 INHIBITING COMPOUND |
| Description | The use of a compound which prevents, inhibits or modifies the action of interleukin-1 as an active agent for the treatment of conditions of neurological degeneration. The active agent may be IL-1 receptor antagonist, particularly recombinant IL-1 ra. |
| IP Reference | WO9308820 |
| Protection | Patent granted |
| Year Protection Granted | 1993 |
| Licensed | No |
| Impact | The data gathered suggest that rhIL-1RA is safe and well tolerated in acute stroke. In addition, rhIL-1RA exhibited biological activity that is relevant to the pathophysiology and clinical outcome of ischaemic stroke. These data demonstrate that rhIL- 1RA has potential as a new therapeutic agent for acute stroke. A pharmacokinetic study of IL-1RA in SAH patients has just been completed(Experimental Medicine grant G0502030). |
| Description | All types and numerous locations; numerous examples |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Primary Audience | Schools |
| Results and Impact | Numerous scientific, public and policy talks - too many to detail. Significant press coverage |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009 |
| Description | Annual STARS lecture, Manchester |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Schools |
| Results and Impact | Annual STARS lecture to ~200 local sixth form and college students. Title: 'A stroke of bad luck: Understanding brain disease' (targeted at A level Biology). Not known. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Frontiers of Science talk, Uni of Manchester |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Frontiers of Science talk delivered to ~150 undergraduate students from 1st year to 3rd year, followed by questions and discussion. Title: "Flaming brains - new discoveries about brain disease" No specific impact known. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Give approx. 10-12 public and schools lectures each year (too numerous to detail) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Schools |
| Results and Impact | Give approx. 10-12 public and schools lectures each year (too numerous to detail) Not possible to detail specific impacts - aim to increase interest in science, particularly in underprivileged areas. Often receive requests from school students wishing to do work experience in the lab, following a talk at their school (all of whom we aim to accommodate wherever possible). |
| Year(s) Of Engagement Activity | 2009 |
| Description | Keynote lecture to Schools Science Conference 2011 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Primary Audience | Schools |
| Results and Impact | Talk followed by Q&A session. Title: "A stroke of bad luck - new discoveries in the treatment of brain disease". Session: Science is the Future. Venue : Royal College of Pathologists, London Audience : 50 secondary year students from years 10-13 and their teachers No specific impact known. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Lecture at the University of Birmingham |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk title: "A stroke of bad luck: mechanisms and treatments for brain disease". For ~200 Uni staff and students. Followed by questions and discussion. No specific impact known. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Numerous scientific, public and policy talks - too many to detail |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Numerous scientific, public and policy talks - too many to detail. Significant press coverage |
| Year(s) Of Engagement Activity | 2006,2007,2008 |
| Description | World Stroke Day 2011 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Had several interactive stands/displays showing different aspects of our preclinical research, at World Stroke Day event in Oct. 2011 organised by our clinical colleagues. The audience comprised ~180 stroke patients and their carers, healthcare professionals and associated charities/organisations. Not known. |
| Year(s) Of Engagement Activity | 2011 |