Mechanisms of interleukin-1 action in neuronal injury

Lead Research Organisation: University of Manchester
Department Name: Life Sciences

Abstract

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Technical Summary

Mechanisms of interleukin-1 action in neuronal injury
 
Description Developmental Clinical Studies
Amount £600,000 (GBP)
Funding ID G1001252 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 05/2011 
End 04/2014
 
Description MRC Models of Disease Grant
Amount £640,000 (GBP)
Funding ID G0801040 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 12/2008 
End 08/2012
 
Description Provision of Amgen IL-1RA for clinical studies 
Organisation Amgen Inc
Country United States 
Sector Private 
PI Contribution Carried out pharmacokinetic study to identify optimal dosing regime of IL-1RA in SAH patients.
Collaborator Contribution Provision of IL-1RA for clinical studies
Impact Pharmacokinetic study identified optimal dosing regime of IL-1RA in SAH patients to take forward to test efficacy in further trials. Phase II randomised controlled double blind trial (IL-1RA vs placebo) now completed in SAH patients (analysis in progress).
 
Description Testing of Novartis's anti-IL-1beta antibody in cerebral ischaemia and neuroinflammation 
Organisation Novartis
Country Global 
Sector Private 
PI Contribution We will test this antibody for neuroprotection in experimental models of cerebral ischaemia and neuroinflammation.
Collaborator Contribution Provision of material for studies
Impact Cerebral ischaemia experiments ongoing. Neuroinflammation experiments finished (in collaboration with cardiovascular colleagues at the University of Sheffield - 3-way agreement); paper in preparation and pending approval from Novartis prior to submission.
Start Year 2009
 
Description Annual STARS lecture, Manchester 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact Annual STARS lecture to ~200 local sixth form and college students.
Title: 'A stroke of bad luck: Understanding brain disease' (targeted at A level Biology).

Not known.
Year(s) Of Engagement Activity 2011
 
Description Biomedical Sciences PhD Student Society, King's College London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Gave talk on career in science to students, which sparked questions and discussion.

None known
Year(s) Of Engagement Activity 2013
 
Description Cheltenham Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Gave a talk on "A stroke of bad luck" to ~200 members of the general public, which sparked questions and discussion.

None known
Year(s) Of Engagement Activity 2013
URL http://www.cheltenhamfestivals.com/science/whats-on/2013/stroke/
 
Description Event for stroke patients and carers, Nov. 2010 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Participants in your research and patient groups
Results and Impact 10 stroke survivors/carers attended an event called "Stroke research - from test tube to treatment", which comprised talks from 3 researchers, spanning preclinical to clinical studies, and interacted with post-docs and students over various displays and refreshments. The feedback from attendees was mostly very positive and all but one expressed an interest in attending future events. The constructive feedback has made us re-evaluate what we want to achieve from such events and will inform future events.

We are re-evaluating the aims of such events and are planning further, larger events, taking into account the feedback received from this meeting. Specifically, we will be involved in a large event for World Stroke Day 2011, with our clinical colleagues.
Year(s) Of Engagement Activity 2010
 
Description Francis Crick Institute Postdoc Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Talk on Career in Science to ~300 students and young researchers across London, which sparked questions and discussion.

None known
Year(s) Of Engagement Activity 2013
 
Description Frontiers of Science talk, Uni of Manchester 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Frontiers of Science talk delivered to ~150 undergraduate students from 1st year to 3rd year, followed by questions and discussion.
Title: "Flaming brains - new discoveries about brain disease"


No specific impact known.
Year(s) Of Engagement Activity 2011
 
Description Give approx. 10-12 public and schools lectures each year (too numerous to detail) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact Give approx. 10-12 public and schools lectures each year (too numerous to detail)

Not possible to detail specific impacts - aim to increase interest in science, particularly in underprivileged areas. Often receive requests from school students wishing to do work experience in the lab, following a talk at their school (all of whom we aim to accommodate wherever possible).
Year(s) Of Engagement Activity 2009
 
Description Highgate Literary and Scientific Institution, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Lecture to ~100 local citizens on my research, which sparked questions and discussion

None known
Year(s) Of Engagement Activity 2013
 
Description International Women's Day, Manchester 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Guest speaker at dinner for International Women's Day, Manchester, to ~150 members of the general public.

None known
Year(s) Of Engagement Activity 2013
 
Description Keynote lecture to Schools Science Conference 2011 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Schools
Results and Impact Talk followed by Q&A session. Title: "A stroke of bad luck - new discoveries in the treatment of brain disease". Session: Science is the Future.
Venue : Royal College of Pathologists, London
Audience : 50 secondary year students from years 10-13 and their teachers

No specific impact known.
Year(s) Of Engagement Activity 2011
 
Description Lecture at the University of Birmingham 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Talk title: "A stroke of bad luck: mechanisms and treatments for brain disease". For ~200 Uni staff and students. Followed by questions and discussion.

No specific impact known.
Year(s) Of Engagement Activity 2011
 
Description Numerous scientific, public and policy talks - too many to detail 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Numerous scientific, public and policy talks - too many to detail.

Significant press coverage
Year(s) Of Engagement Activity 2006,2007,2008
 
Description World Stroke Day 2011 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Participants in your research and patient groups
Results and Impact World Stroke Day event in Oct. 2011 organised by our clinical colleagues. The clinical investigator Dr Tyrrell presented the results of the clinical study funded by this grant. The audience comprised ~180 stroke patients and their carers, healthcare professionals and associated charities/organisations.

Not known.
Year(s) Of Engagement Activity 2011