Mechanisms of interleukin-1 action in neuronal injury
Lead Research Organisation:
University of Manchester
Department Name: Life Sciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
Mechanisms of interleukin-1 action in neuronal injury
People |
ORCID iD |
| Nancy Jane Rothwell (Principal Investigator / Fellow) |
Publications
Hopkins SJ
(2012)
Cerebrospinal fluid and plasma cytokines after subarachnoid haemorrhage: CSF interleukin-6 may be an early marker of infection.
in Journal of neuroinflammation
Smith CJ
(2012)
Interleukin-1 receptor antagonist reverses stroke-associated peripheral immune suppression.
in Cytokine
Cantrill CA
(2012)
An immortalised astrocyte cell line maintains the in vivo phenotype of a primary porcine in vitro blood-brain barrier model.
in Brain research
McMahon CJ
(2013)
Inflammation as a predictor for delayed cerebral ischemia after aneurysmal subarachnoid haemorrhage.
in Journal of neurointerventional surgery
Boutin H
(2013)
[18F]DPA-714: direct comparison with [11C]PK11195 in a model of cerebral ischemia in rats.
in PloS one
| Description | Developmental Clinical Studies |
| Amount | £600,000 (GBP) |
| Funding ID | G1001252 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2011 |
| End | 04/2014 |
| Description | MRC Models of Disease Grant |
| Amount | £640,000 (GBP) |
| Funding ID | G0801040 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2008 |
| End | 08/2012 |
| Description | Provision of Amgen IL-1RA for clinical studies |
| Organisation | Amgen Inc |
| Country | United States |
| Sector | Private |
| PI Contribution | Carried out pharmacokinetic study to identify optimal dosing regime of IL-1RA in SAH patients. |
| Collaborator Contribution | Provision of IL-1RA for clinical studies |
| Impact | Pharmacokinetic study identified optimal dosing regime of IL-1RA in SAH patients to take forward to test efficacy in further trials. Phase II randomised controlled double blind trial (IL-1RA vs placebo) now completed in SAH patients (analysis in progress). |
| Description | Testing of Novartis's anti-IL-1beta antibody in cerebral ischaemia and neuroinflammation |
| Organisation | Novartis |
| Country | Global |
| Sector | Private |
| PI Contribution | We will test this antibody for neuroprotection in experimental models of cerebral ischaemia and neuroinflammation. |
| Collaborator Contribution | Provision of material for studies |
| Impact | Cerebral ischaemia experiments ongoing. Neuroinflammation experiments finished (in collaboration with cardiovascular colleagues at the University of Sheffield - 3-way agreement); paper in preparation and pending approval from Novartis prior to submission. |
| Start Year | 2009 |
| Description | Annual STARS lecture, Manchester |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Schools |
| Results and Impact | Annual STARS lecture to ~200 local sixth form and college students. Title: 'A stroke of bad luck: Understanding brain disease' (targeted at A level Biology). Not known. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Biomedical Sciences PhD Student Society, King's College London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Gave talk on career in science to students, which sparked questions and discussion. None known |
| Year(s) Of Engagement Activity | 2013 |
| Description | Cheltenham Science Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Gave a talk on "A stroke of bad luck" to ~200 members of the general public, which sparked questions and discussion. None known |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www.cheltenhamfestivals.com/science/whats-on/2013/stroke/ |
| Description | Event for stroke patients and carers, Nov. 2010 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | 10 stroke survivors/carers attended an event called "Stroke research - from test tube to treatment", which comprised talks from 3 researchers, spanning preclinical to clinical studies, and interacted with post-docs and students over various displays and refreshments. The feedback from attendees was mostly very positive and all but one expressed an interest in attending future events. The constructive feedback has made us re-evaluate what we want to achieve from such events and will inform future events. We are re-evaluating the aims of such events and are planning further, larger events, taking into account the feedback received from this meeting. Specifically, we will be involved in a large event for World Stroke Day 2011, with our clinical colleagues. |
| Year(s) Of Engagement Activity | 2010 |
| Description | Francis Crick Institute Postdoc Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk on Career in Science to ~300 students and young researchers across London, which sparked questions and discussion. None known |
| Year(s) Of Engagement Activity | 2013 |
| Description | Frontiers of Science talk, Uni of Manchester |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Frontiers of Science talk delivered to ~150 undergraduate students from 1st year to 3rd year, followed by questions and discussion. Title: "Flaming brains - new discoveries about brain disease" No specific impact known. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Give approx. 10-12 public and schools lectures each year (too numerous to detail) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Schools |
| Results and Impact | Give approx. 10-12 public and schools lectures each year (too numerous to detail) Not possible to detail specific impacts - aim to increase interest in science, particularly in underprivileged areas. Often receive requests from school students wishing to do work experience in the lab, following a talk at their school (all of whom we aim to accommodate wherever possible). |
| Year(s) Of Engagement Activity | 2009 |
| Description | Highgate Literary and Scientific Institution, London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Lecture to ~100 local citizens on my research, which sparked questions and discussion None known |
| Year(s) Of Engagement Activity | 2013 |
| Description | International Women's Day, Manchester |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Guest speaker at dinner for International Women's Day, Manchester, to ~150 members of the general public. None known |
| Year(s) Of Engagement Activity | 2013 |
| Description | Keynote lecture to Schools Science Conference 2011 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Primary Audience | Schools |
| Results and Impact | Talk followed by Q&A session. Title: "A stroke of bad luck - new discoveries in the treatment of brain disease". Session: Science is the Future. Venue : Royal College of Pathologists, London Audience : 50 secondary year students from years 10-13 and their teachers No specific impact known. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Lecture at the University of Birmingham |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk title: "A stroke of bad luck: mechanisms and treatments for brain disease". For ~200 Uni staff and students. Followed by questions and discussion. No specific impact known. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Numerous scientific, public and policy talks - too many to detail |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Numerous scientific, public and policy talks - too many to detail. Significant press coverage |
| Year(s) Of Engagement Activity | 2006,2007,2008 |
| Description | World Stroke Day 2011 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | World Stroke Day event in Oct. 2011 organised by our clinical colleagues. The clinical investigator Dr Tyrrell presented the results of the clinical study funded by this grant. The audience comprised ~180 stroke patients and their carers, healthcare professionals and associated charities/organisations. Not known. |
| Year(s) Of Engagement Activity | 2011 |